6th International AIDS Conference


San Francisco, California, USA — June 20-23, 1990

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Idiotype based strategies for controlling HIV infection.

Int Conf AIDS 1990 Jun 20-23; 6:328 (abstract no. 1056)
Kennedy RC; Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78284, USA

OBJECTIVES: To assess various idiotype (Id) based strategies for modulating the in vivo immune response to human immunodeficiency virus (HIV) and develop Id based active immunotherapy schemes.

METHOD: The methods utilize three specific approaches for assessing Id based strategies. The first utilizes immunization with monoclonal anti-CD4 reagents. The second approach uses monoclonal anti-idiotypic antibody (anti-Id) reagents specific for selected HIV-1 gp160 epitopes. The final approach uses anti-Id reagents specific for epitopes on the CD4 molecule.

RESULTS: Each of the three Id based approaches have induced either anti-HIV gp160 and/or anti-CD4 humoral immune responses in a variety of species, including non human primates. The anti-Id nature of these responses have been characterized and will be described.

CONCLUSION: Three different Id based approaches have been used to induce HIV and/or CD4 specific immune responses in vivo. The Id nature of these responses appear to be representative of both noninternal image and internal image specificities. Alteration of the epitope specificity induced by the Id based strategies when compared to responses generated by immunization with the nominal antigen suggests that Id based approaches have applications in preprogramming a given immune response to selected HIV gp160 and/or CD4 epitopes.

Keywords: AEGIS, Immunoglobulin Idiotypes, HIV Infections, Antibodies, Anti-Idiotypic, HIV, Antigens, CD4, HIV-1, Epitopes, HIV Envelope Protein gp120, HIV Antigens, HIV Envelope Protein gp41, HIV Antibodies, Receptors, HIV, HIV Envelope Protein gp160, Immunization, Human, immunology, genetics, ICA6

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