AEGiS-05IAC: Mortality in children with AIDS: age at diagnosis as risk factor.

5th International AIDS Conference

Montreal, Quebec, Canada — Jun 4-9, 1989

Mortality in children with AIDS: age at diagnosis as risk factor.

Int Conf AIDS 1989 Jun 4-9; 5:311 (abstract no. T.B.P.147)

Iosub S, Bamji M, Stone RK, Gromisch DS, Wasserman E; New York Medical College, New York, USA

OBJECTIVE: To compare mortality in children diagnosed as AIDS in the first year of age (group I), vs those diagnosed above one year (group II).

METHODS: The study was performed at two public hospitals in New York City on sixty two patients with perinatal HIV infection, admitted from 1984-1988 and followed for 1-50 months (mean 18 mo). All mothers except three were intravenous drug abusers. The majority of patients in group (G) I were symptomatic in the first six months of life. The G consisted of 42 patients, 14 blacks (b) and 28 Puerto Ricans (PR), 21 males (m) and 21 females (f). G II comprised 20 patients, 13 b and 7 PR, 12 m and 8 f, ranging in age from 12.5 to 72 months (mean 17 mo).

RESULTS: Mortality was significantly higher in GI vs GII: 42% vs 5%, P=0.006. No significant sex and race differences were found in GI (52% mortality in f, 33% in m, 50% in b and 39% in PR), but mortality was higher in b f than b m (80% vs 33%). The majority of patients died of pneumocystis carinii pneumonia (PCP). In GII only 1 PR f died.

CONCLUSION: Infants with perinatal HIV infection who become symptomatic at an early age have a high mortality rate and females seem more at risk. Long term follow-up is needed to establish mortality rates in older infants and children.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, Risk Factors, Pneumonia, Pneumocystis carinii, HIV Infections, Disease Transmission, Vertical, CD4 Lymphocyte Count, Survival Rate, Death, New York City, Child, Infant, Human, Female, Male, diagnosis, mortality, transmission, ICA5

1989-06-04
TBP147