5th International AIDS Conference Montreal, Quebec, Canada — Jun 4-9, 1989

Int Conf AIDS 1989 Jun 4-9; 5:487 (abstract no. B.537)

Young M, McPherson R, Podlasek S, Pierce P; Georgetown University Hospital, Washington, DC, USA

OBJECTIVE: To characterize the serum LDH isoenzyme pattern in HIV patients with elevated LDH and bronchoscopically diagnosed PCP or non-PCP respiratory pathogens.

METHODS: 14 HIV pts presenting with fever, cough, SOB or retenographic findings had serum LDH activity and isoenzyme analysis within 24 hours of bronchoscopy. 2 outpatients with elevated LDH activity but no respiratory complaints were evaluated for isoenzyme analysis (Group C). To assess a standard hospitalized population, 42 non-HIV patients were chosen at random over a 24 hour period for LDH activity and isoenzyme pattern (Group D).

RESULTS: 10/14 HIV/AIDS pts were diagnosed with PCP by bronchoscopy (Group A). In the 4 remaining pts (Group B) no PCP was isolated. TABULAR DATA, SEE ABSTRACT VOLUME.

CONCLUSIONS: Preliminary data suggest: 1) as per previous studies, elevated serum LDH activity correlates with episodes of PCP although background elevation does occur in hospitalized patients and in non-PCP respiratory disease. 2) In PCP, increases in isoenzymes 2 and 3 are noted. In non-PCP respiratory illness isoenzymes 3, 4, 5 are elevated. Further study is needed to confirm if isoenzyme patterns, in particular isoenzyme 2 and 3, are more predictive of PCP than total LDH in the HIV population.

Keywords: AEGIS, Lactate Dehydrogenase, HIV, Acquired Immunodeficiency Syndrome, Enzyme Tests, Isoenzymes, Pneumonia, Bacterial, HIV-1, HIV Infections, Analysis of Variance, Human, ICA5

1989-06-04
B537

Copyright © 1989 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.