4th International AIDS Conference Stockholm, Sweden. — June 12-16, 1988

Int Conf AIDS. 1988 Jun 12-16;4:1.109 (abstract no. PL15)

Reinhard Kurth, P. Centner, A. Werner, S. Hartung, G. Kraus
Paul Ehrlich-Institute, Frankfurt, Federal Republic of Germany

Like HIV in man, animal retroviruses cause a wide variety of diseases, notably cancers and immunodeficiencies in a wide variety of species. With most oncogenic retrovirus strains, however, it is difficult to induce disease in immunocompetent animals, indicating that immune surveillance is effective in limiting virus replication and pathogenesis.

The recognition of the type and nature of viral and virus-induced cellular antigens triggering anti-viral immunity may help to define those HIV antigens required for successful vaccine development. The strategies in HIV vaccine development will have to take into account, however, the variability of the lentivirus envelopes.

Practical animal models for AIDS are still lacking but would help significantly to evaluate experimental vaccines and new drugs for their efficacy against HIV. Attempts to develop such animal models for AIDS will be summarized.

880612
PL15

Copyright © 1988 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.