4th International AIDS Conference


Stockholm, Sweden. — June 12-16, 1988

[TITLE:] THE NINTH CODING SEQUENCE OF HIV-1

Int Conf AIDS. 1988 Jun 12-16;4:1.113 (abstract no. 1003)

Zene Matsuda1, Robert Redfield2, Max Essex1, and Tun-Hou Lee1
1Dept. of Cancer Biology, Harvard School of Public Hlth. 2Dept. of Virus Diseases, Walter Reed Army Inst. of Research

OBJECTIVE: To determine if an open reading frame uniquely present in HIV-1 is a coding sequence.

METHODS: The potential coding sequence was cloned into an expression vectors. Recombinant proteins derived were studied for their reactivity with sera from HIV-1, HIV-2 infected individuals, and uninfected controls.

RESULTS: Seroreactivity was detected in HIV-1 infected individuals. Prevelance rate of this antibody has a bimodal distribution with peaks present at early and late clinical stages. No HIV-2 infected individuals have detectable reactivity to this product.

CONCLUSION: Our results indicate that in addition to gag, pol, env, sor, tat, art/trs, 3'-orf, and R, HIV-1 contains another coding sequence in its genome. Reactivity to this gene product is indicative of HIV-1, but not HIV-2, infection.

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