1st International AIDS Conference Atlanta, Georgia, U.S.A. - April 14-17, 1985

Int Conf AIDS 1985 Apr 14-17; 1:23 (abstract no. S3D)

Lee Ratner, William Haseltine, R Patarca, KJ Livak, B Starcich, SF Josephs
NCI, NIH, Bethesda, Maryland; Dana-Farber Cancer Institute, Boston, Massachusetts; and E.I. duPont de Nemours, Wilmington, Delaware.

DNA sequence analysis of cloned HTLV-III proviruses reveals an organization of the genome unusual for retroviruses. While the gag and pol genes exhibit relatively little variation in organization as compared to HTLV-I, the 3' end of the genome is markedly different from that of HTLV-I. It is likely that the novel potential products of this region may account for the unusual features of the HTLV-III virus, such as trans-activation of its long terminal repeat, cytopathicity, etc.

850414
S3D

Copyright © 1985 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.