18th International HIV Drug Resistance Workshop Basic Principles & Clinical Implications June 9–13 2009, Fort Myers, Florida, USA

ERADICATION OF HIV INFECTION: ANY PROBLEM, HOWEVER COMPLICATED, IF LOOKED IN THE RIGHT WAY, BECOMES MORE COMPLICATED

Antivir Ther 2009; 14 Suppl 1:A3 (abstract no. 1)

D Margolis
Michael Hooker Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

The causes of persistence of HIV infection in the face of current therapy appear to be multifactorial: latent but replication-competent provirus in resting CD4+ T-lymphocytes, cryptic viral expression below the limits of detection of clinical assays and viral sanctuary sites might all contribute to persistence. Clearance of HIV infection will almost certainly require a multimodality approach that includes potent suppression of HIV replication, therapies that reach all compartments of residual HIV replication and depletion of any reservoirs of persistent, quiescent proviral infection. This overview will highlight the basic mechanisms for the establishment and maintenance of viral reservoirs and potential approaches towards their elimination.

2009-06-09
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