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1st International Workshop on HIV Drug Resistance & Treatment Strategies25-28 June 1997, St. Petersburg, Florida, USA |
THE DISCOVERY AND DEVELOPMENT OF ANTIRETROVIRAL DRUGS
Antiviral Therapy 1997;2 (Suppl 5):1 (abstract no. 1)
Joel R Huff
Merck Research Laboratories, West Point, Pennsylvania, USA
Recently, a number of promising therapeutic agents for the treatment of HIV have emerged. While long-term efficacy remains to be established, initial results with several new treatment regimens appear to be quite encouraging. Discovery and development of these new agents have required almost a decade of intense effort, despite quite early identification of key targets for drug discovery. The rate-limiting step for introducing these drugs into the clinic has seldom been related to optimizing intrinsic activity toward a specific biological target. Rather, the most time consuming element is most often associated with improving the metabolic, pharmacokinetic and toxicological properties of potential drug candidates. Strategies for addressing the challenges encountered in moving from basic biological observations to clinically effective therapeutic agents will be discussed.
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1997-06-25
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