Third International Congress Drug Therapy in HIV Infection 3-7 November 1996 Glasgow, UK

ACUTE HIV INFECTION: CLINICAL PRESENTATION AND TREATMENT

Hirschel B
Infectious Diseases Unit, University Hospital, CH-1211 Geneva 14

Int Cong Drug Therapy HIV 1996 Nov 3-7;3:Abstract No. 2.2
AIDS 1996, Vol. 10 (Suppl. 2);S1

Primary HIV infection is a disease with protean manifestations. Some of these resemble infectious mononucleosis, but neurological, cutaneous and digestive signs and symptoms are equally frequent. Both the severity and the duration of PHI presage subsequent accelerated immunosuppression and progression towards Aids.

Treatment of PHI occurs in the context of a still relatively intact immunsystem and a relatively homogenous viral population. These circumstances favour the success of therapeutic interventions. Zidovudine monotherapy reduced the incident of minor opportunistic infections but had negligeable effect on plasma viremia. Treatment with two or three drugs is capable of suppressing viremia to undetectable levels and normalizing immunologic parameters, including the CD4-CD8 ratio after disappearance of HIV from plasma, lymph node biopsies are all also HIV-negative. Whether erradication of HIV infection is possible is still unknown; results can be expected during 1997.

Presenting author: Hirschel B

1996-11-03
2.2

Originally published in AIDS Volume 10, Supplement 2 and hosted with permission of the publisher Lippincott Williams & Wilkins, 250 Waterloo Road, London, SE1 8RD, UK. Tel: +44 (0)20 7981 0700 Fax: +44 (0) 7981 0701

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