Third International Congress Drug Therapy in HIV Infection 3-7 November 1996 Glasgow, UK

HIV DRUG RESISTANCE — AN OVERVIEW

Douglas D. Richman
University of California San Diego and the San Diego VA Medical Center, La Jolla, CA, 92093-0679

Int Cong Drug Therapy HIV 1996 Nov 3-7;3:Abstract No. 12.1
AIDS 1996, Vol. 10 (Suppl. 2);S7

The complex connection from development of drug resistance to loss of antiretroviral drug activity to diminished control of virus replication to increased rate of destruction of CD4 lymphocytes to increased risk of opportunistic events to death has confounded simple correlations of antiviral drug resistance to survival. Evidence supporting this relationship has been generated for AZT monotherapy with ACTG trial 116B/117 and more recently with trials of combination nucleoside regimens. The correlation of loss of antiviral drug activity with the emergence of drug resistance has been quite straightforward for the non-nucleoside reverse transcriptase inhibitors and the potent protease inhibitors. Prevention of resistance will prove central to the new chemotherapeutic paradigm of complete suppression of HIV replication with potent combination regimens. The impact upon survival of this strategy is highly likely but not yet confirmed.

Presenting author: Douglas D. Richman

1996-11-03
12.1

Originally published in AIDS Volume 10, Supplement 2 and hosted with permission of the publisher Lippincott Williams & Wilkins, 250 Waterloo Road, London, SE1 8RD, UK. Tel: +44 (0)20 7981 0700 Fax: +44 (0) 7981 0701

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