AEGiS-05CROI: Epstein-Barr virus and lymphoma in patients with HIV.

5th Conference on Retroviruses and Opportunistic Infections

Chicago, IL - February 1-5, 1998

Epstein-Barr virus and lymphoma in patients with HIV.

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:231 (abstract no. S9)

Ambinder RF; Ambinder RF

The association of EBV with lymphomas in immunocompromised patients is well known. The virus is routinely detected in tumor tissue by EBER in situ hybridization. It may also be detected in many instances by immunohistochemistry. EBV is associated with approximately 50% of non-Hodgkin's lymphomas in AIDS patients and nearly 100% of Hodgkin's lymphomas. Among the non-Hodgkin's lymphomas, the association is particularly strong with primary central nervous system lymphoma. This has led to a new diagnostic approach which combines imaging studies and cerebrospinal fluid PCR as an alternative to brain biopsy. Primary effusion lymphomas are rare tumors that generally harbor both EBV and HHV8. In bone marrow transplant recipients, adoptive immunotherapy with EBV-specific cytotoxic T lymphocytes has emerged as an important therapeutic and prophylactic modality. This approach has promise in the treatment of EBV-associated lymphoma in other settings including AIDS.

Keywords: AEGIS, Herpesvirus 4, Human, Lymphoma, HIV, Central Nervous System Neoplasms, Lymphoma, Non-Hodgkin, In Situ Hybridization, Hodgkin Disease, Herpesvirus 8, Human, Polymerase Chain Reaction, Immunocompromised Host, Immunohistochemistry, Acquired Immunodeficiency Syndrome, Human, immunology, AIDS

1998-02-01
S9

Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.