AEGiS-05CROI: Multiple symmetrical lipomatosis associated with protease inhibitor therapy.

5th Conference on Retroviruses and Opportunistic Infections


Chicago, IL - February 1-5, 1998



Multiple symmetrical lipomatosis associated with protease inhibitor therapy.

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:156 (abstract no. 407)

Hengel RL, Geary JA, Vuchetich MA, Swartz AS, Brachman PS, Watts NB, Lennox JL; Emory University, Atlanta, GA. Fax: (404) 880-9305.

Multiple symmetrical lipomatosis (Madelung or Launois-Bensaude syndrome) is an uncommon condition observed primarily in men who abuse alcohol. It is characterized by the abnormal deposition of unencapsulated fat in the neck and shoulder areas in a "horse collar" distribution. We report 4 cases of this disorder that we observed following the initiation of protease inhibitor therapy.

METHODS: A case was defined when a physician observed accumulation of abnormal fat deposition outside of the areas normally associated with male or female obesity. All providers in the Grady Infectious Diseases Program, an urban clinic caring for approximately 4,000 HIV-infected adults, were contacted and asked to report any cases as defined above. In addition, a single case was collected from a large private practice in Atlanta.

RESULTS: Three men and one woman were observed to fit the case definition. The median time on protease inhibitor therapy prior to the diagnosis as a case was 6 months. All patients received indinavir, three in combination with zidovudine/lamivudine, and one with stavudine. All denied a history of alcoholism or an increase in alcohol intake. All had abnormal accumulations of fat over the shoulders and neck (development of a "buffalo hump"), and the one woman had an increase in breast size and abdominal girth. One patient had elevated glucose levels, and two had minimally elevated triglyceride levels. Dexamethasone suppression tests were normal. Clinical characteristics and photographs will be presented.

Keywords: AEGIS, Lipomatosis, Multiple Symmetrical, Protease Inhibitors, Indinavir, Anti-HIV Agents, HIV Protease Inhibitors, Lipomatosis, HIV Infections, Reverse Transcriptase Inhibitors, HIV-1, Stavudine, Lamivudine, Zidovudine, HIV, Skin Diseases, Abdomen, Drug Therapy, Combination, Human, Male, Female, Adult, therapy, drug therapy, AIDS

1998-02-01
407

Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.