14th Annual Conference of the British HIV Association 23-25 April 2008, Belfast

INFLUENZA VACCINATION IN A LARGE TERTIARY HIV CENTRE IN THE UK

HIV Med 2008 Apr 23-25 (Suppl 1);14:13 (abstract no. P13)

M Mirfenderesky, P Khan, T Fernandez, L Swaden, M Johnson and S Hopkins
Royal Free Hospital, London, UK

BACKGROUND: Influenza (IF) in HIV infected individuals is associated with more prolonged illness, increased rates of hospitalisation and death. Department of Health recommends an influenza vaccination (IFV) rate of 70% in patients with increased complications from IF. The aim of this study was to determine the IFV rate at our centre and to determine any differences in demographics between the IFV and non-IFV groups.

METHODS: The IFV rate at the centre was calculated from pharmacy distribution data. Demographic and HIV data was extracted from a centralised database and the hospital computerised result system for all patients that attended between the 01/10/2007 and 31/12/2007. Statistical analysis was performed using STATA 8.0.

RESULTS:Approximately 2600 HIV+ individuals attended for continuing care in 2007. Four hundered and seventy five IF vaccines were administered resulting in an IFV rate of 18%. During the study period, 288/2135(13%) patients received IFV. There were over 6000 attendances (mean 2.8/patient). No differences in age, sex, ethnicity, CD4 counts or clinical stage of HIV infection were found between the IFV and non-IFV groups. IFV was adminstered more frequently to those with a lower viral load (IFV:7927 cpm; no IFV:25615 cpm; P=0.001) and on ARV (IFV:92%; no IFV:86%; P=0.005).

CONCLUSIONS: There were multiple missed IFV opportunities in this HIV population who attend. Low vaccine uptake, especially in those not on ARVs or with higher viral loads, may be due to either provider or patient reservations about vaccine safety or efficacy. We plan to implement a multimodal educational package to both staff and patients ahead of next years IFV programme to improve uptake in our centre.

2008-04-23
P13

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