14th Annual Conference of the British HIV Association 23–25 April 2008, Belfast

LOW PREVALENCE OF TRANSMITTED ANTIRETROVIRAL DRUG RESISTANCE IN A LARGE UK HIV-1 COHORT

HIV Med 2008 Apr 23-25 (Suppl 1);14:2 (abstract no. O7)

B Payne¹, E Nsutebu², E Hunter³, O Olarinde⁴, P Collini⁴, J Dunbar⁵, M Basta², J Elston⁶, M Schmid³, H Thaker⁶ and D Chadwick^1
1James Cook University Hospital, Middlesbrough, UK, ²Bradford Teaching Hospitals Foundation Trust, Bradford, UK, ³Newcastle General Hospital, Newcastle-upon-Tyne, UK, ⁴Royal Hallamshire Hospital, Sheffield, UK, ⁵St James’ Hospital, Leeds, UK, ⁶Castle Hill Hospital, Cottingham, Hull, UK

OBJECTIVES: To describe current practice in testing for transmitted antiretroviral drug resistance (TDR), and the prevalence of TDR in a large UK HIV-1 cohort.

METHODS: Retrospective analysis of newly diagnosed HIV-1 infected patients presenting March 2005 to March 2007 to eight HIV clinics in the North of England. Resistance mutations were defined by IAS-USA. Predicted phenotypes were calculated by Stanford University database.

RESULTS: Five hundred and fifty eight patients were studied of whom 394 (70.6%) had heterosexually-acquired HIV and 377 (67.6%) were infected outside the UK. TDR testing was performed in 406 patients (72.8%). 13/ 392 viral resistance profiles (3.3%) showed genotypic TDR. There was no significant association between TDR and any demographic or risk factor or baseline CD4 count. In particular, rates of TDR were similar in white British (6/147, 4.1%) and black African (7/224, 3.1%) patients. Numbers of patients with TDR to individual drug classes were: NRTI (TAMs), 2 (0.5%); NNRTI, 7 (1.8%); major PI, 4 (1.0%). No patients had more than single-class resistance. 11 patients (2.8%) were predicted to have significant phenotypic resistance to at least one drug.

CONCLUSIONS: In a large unselected UK cohort, with high coverage of TDR testing, the prevalence of TDR was substantially lower than in most published literature. Differences in population mix did not appear to explain this low rate. TDR rates in the UK may now be falling compared with historical data.

2008-04-23
O7

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