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11th Annual Conference Of The British HIV Association [BHIVA]20–23 April 2005, Burlington Hotel·Dublin·Ireland |
[AUTHOR(S):] TR Chadborn, VC Delpech, K Sinka, BD Rice, BG Evans
HIV/STI Department, Health Protection Agency's Centre for Infections, London, UK
BHIVA Conf 2005 Apr 20-23;11:O19
AIMS: To determine factors associated with late diagnosis of individuals, sexually infected with HIV, and the impact this had on short-term mortality.
METHODS: Analysis of national HIV/AIDS case reports of new diagnoses linked to CD4 cell counts from the CD4 Surveillance Scheme. Outcomes were late diagnosis (CD4 <200 cells/mm3) and short-term mortality (death within a year of diagnosis).
RESULTS: 38% of 3,596 individuals sexually infected with HIV (with CD4 counts at diagnosis) were diagnosed late. Late diagnosis affected 26% of homosexual men, 49% of heterosexual men and 40% of heterosexual women (22% where diagnosis was antenatal). Late diagnosis increased with age. Black Africans were diagnosed later than white individuals (although not evident after stratifying by other factors). There were 137 (2.6% of 5,200) deaths within a year of HIV diagnosis. Short-term mortality was 6.2% for individuals diagnosed late and 0.5% for others (excluding pregnant women for whom it was 0.4% overall). Early diagnosis could have markedly reduced short-term mortality and all mortality in 2002.
CONCLUSIONS: Continued late diagnosis, particularly of older and heterosexual individuals, means missed opportunities to start therapy early and to prevent further transmission, and an approximate 10 times higher risk of death within a year of diagnosis.
PRESENTING AUTHOR: TR Chadborn
2005-04-20
O19
Copyright © 2005 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD