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8th Annual Conference Of The British HIV Association [BHIVA]19 – 21 April 2002, University of York, York |
[AUTHOR(S):] AA Obi, BG Gazzard, SM Mitchell
St Stephen's Centre, Chelsea & Westminster Hospital, London
BHIVA Conf 2002 Apr 19-21;8:O27
OBJECTIVE: To describe the risk factors and response to treatment of HIV-1-infected patients developing new retinal infections in the post- HAART era.
METHODS: Review of HIV-1-infected patients developing new retinal infections between 1998 and 2002 to determine their risk factors and response to treatment.
RESULTS: 37 patients (24 men, 13 women) developed a new retinal or choroidal infection over the study period. The majority of patients were Caucasian (57%) although 41% were black (mainly African); 51% of patients were homosexual and 46% were heterosexual; 49% had a new or recent HIV diagnosis, while 38% had failed to respond to HAART. Infection was due to cytomegalovirus in 28 (76%) patients, varicella-zoster virus in six (16%), cryptococcus in two, with one case each being due to toxoplasmosis and miliary tuberculosis; 11 patients died within 17 months of diagnosis (mean 7.1 months). The median CD4 count and HIV viral load at ocular diagnosis were 17 cells/µL (range 1–245) and 5.17 log10 copies/mL (range 1.00 –5.70), respectively. Discontinuation of treatment was possible in seven patients following immune reconstitution on HAART.
CONCLUSIONS: Despite the increasing availability of HAART, retinal infections continue to occur, with the majority of patients having a new or recent HIV diagnosis.
PRESENTING AUTHOR: AA Obi
020419
O27
Copyright © 2002 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD