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3rd International AIDS Society Conference on HIV Pathogenesis and TreatmentRio de Janeiro - July 24 - 27, 2005 |
RECOMBINANT HEPATITIS B VACCINATION IN PATIENTS WITH HIV/AIDS: IMMUNE RESPONSES AND EFFECTIVENESS
IAS Conf HIV Pathog Treat 2005 Jul 24-27;3rd: Abstract No. TuPe1.1C41
Sud A., Kumari N., Arora S., Singh S., Chawla Y.
PGIMER, Chandigarh, India
INTRODUCTION: Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) share risk factors for transmission of infection. Hence co-infection with HIV and HBV is common. Prevention of HBV infection is feasible. However, response to HBV vaccination in HIV infected patients maybe attenuated. We evaluated immune responses among HIV-infected patients against recombinant HBV vaccine
METHODS: Response to HBV vaccination of 27 patients with CD4 counts >200/mm³ (Group-A), 13 with counts <200/mm³ (Group-B) and 20 controls (Group-C) was compared. Anti-HBs antibodies were measured by ELISA; CD3+, CD4+, CD8+, CD45RA+, CD45RO+ and CD15+56+ T cells were measured using FACScan-flowcytometer at baseline, before and 2 weeks after 2nd and 3rd doses of vaccine.
RESULTS: Anti-HBs titers increased significantly in all patients in Group-A, 47% in Group-B and 90% in Group-C. Antibody titers were highest in Group-C compared to other groups (p=0.05 group A vs C; p<0.01 group B vs C); titers were higher in Group-A vs Group-B, p<0.05. The CD4 and CD8 counts increased in all groups. Baseline CD45RA+ cell counts were lower in Group-B and increased after vaccination in all groups. CD45RO+ cells increased after the 2nd dose in Groups-A and C but increased only after the 3rd dose in Group-B. The CD15+56+ increased after each dose in Group-C, after the 3rd dose in Group-B and did not increase in Group-A.
CONCLUSIONS: Antibody response to HBV vaccination is sub-optimal in HIV-infected patients. The titers are lowest in patients with CD4 counts <200/mm³. Basal naïve cell counts, though lower in patients with CD4 <200/mm³, increase after vaccination. The increase in memory cells occurs later in patients with CD4 count <200/mm³.
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Clinical | TuPe1.1C41 | Archana Sud
Hepatitis viruses
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