3rd International AIDS Society Conference on HIV Pathogenesis and Treatment Rio de Janeiro - July 24 - 27, 2005

DIFFERENCES IN NEUROPSYCHOLOGICAL FUNCTIONING BETWEEN HIV+ AND HIV+/HCV+ INFECTED PATIENTS

IAS Conf HIV Pathog Treat 2005 Jul 24-27;3rd: Abstract No. TuPe1.1C35

Muñoz-Moreno J.A.¹, Fumaz C.R.¹, Prats A.¹, Ferrer M.J.¹, Negredo E.¹, Moltó J.¹, López-Blázquez R.², Gómez G.², Garolera M.³, Clotet B.^1
1Lluita contra la SIDA Foundation - Germans Trias i Pujol University Hospital, Barcelona, Spain, ²Departament d'Estadística i Investigació Operativa - Universitat Politècnica de Catalunya, Barcelona, Spain, ³Consorci Sanitari Hospital de Terrassa, Barcelona, Spain

INTRODUCTION: Neuropsychological functioning (NF) in HIV+ and HCV+ monoinfected patients may impair, and it has been suggested that HIV/HCV-coinfected patients might show more impaired NF. This study assesses NF in both HIV-monoinfected and HIV/HCV-coinfected population to seek possible differences in this performance.

METHODS: Descriptive, observational study where 50 HIV+ infected patients have been assessed (Group (G) 1: 40 HIV+/HVC- patients, G2: 10 HIV+/HCV+ patients). A neuropsychological tests battery was designed to evaluate NF (motor, verbal fluency, information processing speed, memory, learning, attention/working memory and executive functions). Depression and anxiety were controlled (BDI and STAI tests), as well as premorbid intelligence, age, education, employment situation, CD4+ cell count, CD4+ nadir, viral load, disease stage, existence of psychiatric or neurological disorder, HIV infection risk practice, treatment adherence, HAART regimen and previous treatments. Patients who reported toxics' consumption, psychotherapeutic or psychiatric treatment or interferon treatment were excluded of the study. Statistical comparisons with ANOVA and non-parametrical tests have been developed, and corrected T scores to age, education and gender have been also calculated.

RESULTS: G1 scored higher than G2 in following areas: fine motor speed (dominant hand: G1:median:60.50, range:57-64.75, G2:median:66.5, range:61.5-74, p=0.023; non-dominant hand: G1:mean:64.97, sd:12.09, G2:mean:76.9, sd:8.37, p=0.005); verbal fluency (cowat: G1:mean:41.15, sd:7.62, G2:mean:35.3, sd:10.08, p=0.048); and executive functions (non-problem solved: G1:median:0.00, range:0-0, G2:median:0.00, range:0-1, p=0.037). Although significant differences were not observed in depression (G1:median:5, range:1-9.25, G2:median:5.5, range:1.75-12.75, p=0.197) and anxiety (G1:mean:38.08, sd:10.109, G2:mean:42.20, sd:13.214, p=0.290), education (G1:median:14.5, range:10.25-17, G2:median:9.5, range:8-11.25, p=0.008) and gender (G1:77.5%-22.5%, G2:40%-60%, p=0.021) showed statistical signification. Corrected T scores detected high values in G1 in: fine motor speed (dominant hand: G1:median:56, range:50.25-61.75, G2:median:50.50, range:42.75-53.75, p=0.034; non-dominant hand: G1:mean:56.18, sd:9.951, G2:mean:44.4, sd:10.824, p=0.002); and executive functions (perseverative error: G1:median:49, range:45.25-52.75, G2:median:55.5, range:49.75-62, p=0.012).

CONCLUSIONS: Differences in NF are found between HIV-monoinfected and HIV/HCV-coinfected patients. Coinfected subjects show significant impairment in motor performance, verbal fluency and executive functions.

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Clinical | TuPe1.1C35 | Jose A. Muñoz-Moreno
Hepatitis viruses

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