3rd International AIDS Society Conference on HIV Pathogenesis and Treatment Rio de Janeiro - July 24 - 27, 2005

HIV/HCV AND HIV/HBV CO-INFECTIONS PREVALENCE IN A COHORT OF ROMANIAN ADULT PATIENTS

IAS Conf HIV Pathog Treat 2005 Jul 24-27;3rd: Abstract No. TuPe1.1C33

Benea E., Popescu G.-A., Popescu C., Badea G., Ivan M., Gavriliu L.C.
Matei Bals Infectious Diseases Institute, Bucharest, Romania

OBJECTIVE: To describe the prevalence of HIV-viral hepatitis co-infection in adult patients followed in "Matei Bals" Infectious Diseases Institute, Bucharest.

METHODS: We analyzed the 1990-2005 database of HIV infected patients, monitored in our Institute, selecting only the patients aged 14 years or over at the moment of examination.

RESULTS: We founded 942 patients tested for HBV and/or HCV infection (16% of all Romanian adult HIV infected patients). 835 of them were tested for anti-HCV antibodies and 938 patients were tested for HBV infection. 57 patients were anti-HCV positive (6.82%); 4 of them lost the antibodies during the surveillance period. The greatest risk for HIV/HCV co-infection was recorded for the patients born between 1951-1965: 25/236 (10.59%), OR=2.05 (1.14-3.65). From 938 patients tested for HBV infection, 349 had at least one HBV marker (37.2%): - 127 patients were HBsAg positive (13.53%) - 23 of the HBsAg negative patients were anti-HBc positive and anti-HBs negative: occult HBV infection (2.45%) - 127 of the HBsAg negative patients were anti-HBc positive and anti-HBs undetermined (13.53%) - 72 patients had anti-HBs titer > 10 UI/l, without vaccination (7.67%). During surveillance period, 8 patients lost HBs antigen (6.29%) and one of them made HBs seroconversion. The greatest risk for HIV/HBV co-infection was recorded for the HIV infected patients born between 1981-1990: 28/113 (24.77%) had HBV active infection, OR=2.40 (1.45-3.97).

CONCLUSIONS: The prevalence of HIV/HCV co-infection is very low compared with European Western countries, associated with the low level of intravenous drug HIV-acquired infection in Romania. The situation of HIV/HBV is opposite: high level, similar with other Southern European countries. The raised level of HIV/HBV co-infection in patients born between 1981-1990 could be correlated with some gaps in infection-control practices in the last years of communist period in Romania (1985-1990).

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050724
Clinical | TuPe1.1C33 | Elisabeta Benea
Hepatitis viruses

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