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2nd International AIDS Society Conference on HIV Pathogenesis and TreatmentParis, France - July 13 - 16, 2003 |
IAS Conf HIV Pathog Treat 2003 Jul 13-16;2nd: Abstract No. 954
Antiviral Therapy 2003; 8(Suppl. 1):S453
[ABSTRACT:] Objective: To determine the epidemiology and distribution of HIV-1 and HCV among intravenous drug users and illegal blood donors in China.
Methods: Polymerase chain reaction (PCR) amplification and sequencing were used to evaluate the HIV-1 gag p17 and env C2-V3 regions, as well as the HCV 5'NCR and E1/E2 regions.
Results: Among 239 subjects with reported HIV-1 infection, 56.9% (136/239) were seropositive. Of those, 96.3% (131/136) were co-infected with HCV through intravenous drug use and illegal blood donation. Intravenous drug users in Yunnan, Guangxi and Xinjiang provinces were infected with HIV-1 subtype C and HCV genotypes 1b, 3a, 3b and 4, whereas illegal blood donors in Henan province harbored HIV- 1 subtype B' and HCV genotypes 1b and 2a. Five different HIV-1 subtypes were identified among 17 HIV-1-infected individuals from Beijing.
Conclusions: Multiple HIV-1 subtypes and HCV genotypes were identified in China and are associated with several different modes of transmission. Homogeneity within the sequences of these two viruses suggests recent, but separate, outbreaks of HIV-1 and HCV. The distinct distribution patterns of HIV-1 and HCV genotypes in two high-risk groups is more closely linked to the mode of transmission than to geographical proximity.
Key words: Human acquired immunodeficiency virus I (HIV-1); hepatitis C virus (HCV); genotype; epidemiology.
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Copyright © 2003 - International AIDS Society (IAS) and International Medical Press (IMP). Reproduction courtesy of International Medical Press.