[153] FREQUENCY, PATTERNS AND CORRELATES OF HIV TRANSMISSION RISK BEHAVIORS AMONG HIV SEROPOSITIVE PATIENTS IN CLINICAL CARE

1st International AIDS Society Conference on HIV Pathogenesis and Treatment

Buenos Aires, Argentina - July 8-11, 2001

[TITLE:] SIDE EFFECTS ASSOCIATED WITH POST-EXPOSURE PROPHYLAXIS IN A POPULATION BASED SETTING

[AUTHOR(S):] Braitstein P, Chan K, Beardsell A, McLeod A, Montaner J, O'Shaughnessy M, Hogg R
BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, University of British Columbia Vancouver, British Columbia, Canada

IAS Conf HIV Pathog Treat 2001 Jul 8-11;1st: Abstract No. 153

[ABSTRACT:] Background: To examine side effect profiles of individuals receiving triple versus double combination post-exposure prophylaxis (PEP) against HIV-infection.

Methods: Since 1996, the BC Centre for Excellence in HIV/AIDS has had a population-based accidental HIV exposure program. This analysis was restricted to individuals potentially exposed to HIV occupationally or in the community who received either dual or triple therapy between 04/99–11/00. Data was collected through dispensation of accidental exposure kits, their prescription forms, and a self-administered survey regarding the nature of the exposure, as well as side effects. Statistical analyses used non-parametric methods and stepwise logistic regression to identify patient and exposure characteristics independently associated with experiencing side effects.

Results: During the study period, 2064 starter kits were dispensed. Of these, 1601 (78%) were prescribed dual therapy (d4T/3TC) and 403 were prescribed triple (22%). As of 08/99, there were 434 individuals who received the 23-day follow-up kit, of whom 371 were sent the self-administered survey (sexual assault cases were excluded). Of these, 106 (29%) returned completed questionnaires. Individuals who returned surveys were more likely to have had an occupational needlestick injury. People on triple combination were more likely to experience almost all gastrointestinal (p<0.001), neuropathic (p=0.016), and liver side effects (p=0.033). People on triple therapy experienced more rash (p=0.038), headache (p=0.012), and fatigue (p=0.023). Women (p=0.008) and people exposed occupationally (p=0.048) were significantly more likely to experience any side effect.

Conclusions: Our analysis suggests that people on triple combination post-exposure prophylaxis experience more gastrointestinal, liver, and neuropathic side effects. This data also indicates that women and individuals who were exposed occupationally are more likely to experience side effects.

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