Important note: Information in this article was accurate in 2003. The state of the art may have changed since the publication date. The three antiretroviral drugs such as Efavirenz,Lamivudine &
Zidovudine better known as AZT combination is the best of all
others indicated on the study .But what is not clear for me
infected, I am not a professional in the field . According to AEGIS
suggestion table a patient should take at list from the three
group of drugs such as Nucleoside/tide reverse transcriptase
inhibitors(NRTIs), Protease Inhibitors(PIs) & None-nucleoside
Reverse Transcriptase Inhibitors(NnRTIs) one from each group. But
from the table Lamivudine & Zidovudine belongs to the same group
NRTIs these is not clear to me I need your help
to understand.
Thank you for your cooperation!!
I believe that you are referring to ACTG study number 384, which compared several different drug combinations and found that Efavirenz, Lamuvidine, and Zidovudine gave the longest sustained response with the fewest problems. Is this correct?
Drug combinations typically contain at least three different drugs. They do not each need to be from three different classes of drugs. Most "cocktails" contain two nucleoside reverse transcriptase inhibitors, along with either a protease inhibitor, or a non-nucleoside reverse transcriptase inhibitor. This would be three drugs, from two different classes.
All number of combinations have been tried, even combinations of three nucleoside reverse transcriptase inhibitors, which proved disappointing. As new classes of drugs are developed, more different types of combinations will be seen. Perhaps, if more powerful drugs come, fewer agents will be needed.
Please let me know if I can be of further help.
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