Important note: Information in this article was accurate in 2003. The state of the art may have changed since the publication date.



Question:

I have been on antiretrovirals (stocrin and combivir) for 8 months now. My CD4 [T-cell count] is at 280 and my viral load is undetectable, BUT I have noticed my nails , basically my fingers turning dark and the soles of my feet and toes turning dark - are these the "side effects"?

Is there anything I can do to make them lighter again - they look terrible and I cannot keep wearing "closed" shoes or socks with sandals all the time. When one looks at my feet they will think I do not wear shoes at all and do not wash them .
Please advise. And thank you for this website !

Answer provided by Daniel H. Bowers, M.D.:


Dear Reader,
The AZT component of Combivir is most likely causing the nail discoloration. This is a well-known side effect of AZT, but I don't know of any way to counteract this color change. Fortunately this is not damaging to the nails, and the nails will grow out normal again when the AZT is discontinued.



AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, Elton John AIDS Foundation, John M. Lloyd Foundation, Roche and Trimeris, the National Library of Medicine, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, and donations from users like you. Always watch for outdated information. This article first appeared in 2003. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2003. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content.