Cervical intra-epithelial neoplasia (CIN) III of the uterine cervix in a young female associated with AIDS [published erratum appears in Pathol Int 1996 May;46(5):392] NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Cervical intra-epithelial neoplasia (CIN) III of the uterine cervix in a young female associated with AIDS [published erratum appears in Pathol Int 1996 May;46(5):392]

Pathol Int. 1996 Feb;46(2):161-4. Unique Identifier : AIDSLINE MED/20305920
Kimura M; Sata T; Kurata T; Maekura S; Satou T; Akiyama H; Nakajima S; Hashimoto S; Second Department of Pathology, Kinki University School of; Medicine, Osaka-Sayama, Japan.

Abstract: A case of cervical intraepithelial neoplasia (CIN) III implying severe dysplasia or carcinoma in situ of the uterine cervix in a 24 year old Japanese female patient with acquired immunodeficiency syndrome (AIDS) is reported. Autopsy revealed marked systemic atrophy of lymph nodes, Pneumocystis carinii pneumonia, pulmonary aspergillosis, acute pancreatitis and CIN III of the portio vaginalis uteri. The human papillomavirus (HPV) genome was detected in sections of the CIN III by polymerase chain reaction. This is the first autopsy report of cervical neoplasia in a patient with AIDS in Japan, and the pathogenesis of CIN III in this case was associated with HPV infection. Gynecological examination should be mandatory for female patients with human immunodeficiency virus infection.
Keywords: JOURNAL ARTICLE AIDS-Related Opportunistic Infections/PATHOLOGY Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PATHOLOGY Adult Case Report Cervical Intraepithelial Neoplasia/COMPLICATIONS/*PATHOLOGY/ VIROLOGY Cervix Neoplasms/COMPLICATIONS/*PATHOLOGY/VIROLOGY DNA, Viral/ANALYSIS Fatal Outcome Female Human Neoplasm Staging Papillomavirus, Human/GENETICS/ISOLATION & PURIF Papovaviridae Infections/COMPLICATIONS/PATHOLOGY Polymerase Chain Reaction Tumor Virus Infections

KWDjournalarticleaids-relatedopportunisticinfections/pathologyacquiredimmunodeficiencysyndrome/complications/KWDpathologyadultcasereportcervicalintraepithelialneoplasia/complications/KWDpathology/virologycervixneoplasms/complications/KWDpathology/virologydna,viral/analysisfataloutcomefemalehumanneoplasmstagingpapillomavirus,human/genetics/isolation&purifpapovaviridaeinfections/complications/pathologypolymerasechainreactiontumorvirusinfections
000930
A0091468

Copyright © 2000 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Elton John AIDS Foundation, the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2000. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2000. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .