Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers.

Clin Diagn Lab Immunol. 2000 May;7(3):515-8. Unique Identifier : AIDSLINE MED/20261966
Hocini H; Becquart P; Bouhlal H; Adle-Biassette H; Kazatchkine MD; Belec L; Unite INSERM U430, Paris, France.

Abstract: In the present study, we demonstrate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) inhibits infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes with laboratory-adapted isolates and with the primary isolate, NDK, of free human immunodeficiency virus type 1 (HIV-1). In contrast, rhSLPI did not exhibit inhibitory activity toward transcytosis of cell-associated HIV-1 through a tight monolayer of endometrial epithelial cells. These observations indicate that the inhibitory effect of SLPI is restricted to free HIV-1 in corporal fluids.
Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/IMMUNOLOGY/PREVENTION & CONTROL/*TRANSMISSION Cervix Uteri/CYTOLOGY/VIROLOGY Epithelial Cells/DRUG EFFECTS/METABOLISM/VIROLOGY Female Gene Expression/IMMUNOLOGY Human HIV Seronegativity *HIV-1 Lymphocytes/DRUG EFFECTS/METABOLISM/*VIROLOGY Monocytes/DRUG EFFECTS/METABOLISM/*VIROLOGY Proteins/GENETICS/IMMUNOLOGY/*PHARMACOLOGY Recombinant Proteins/PHARMACOLOGY RNA, Messenger/ANALYSIS Serine Proteinase Inhibitors/IMMUNOLOGY/*PHARMACOLOGY Support, Non-U.S. Gov't Tight Junctions/METABOLISM/VIROLOGY

KWDjournalarticleacquiredimmunodeficiencysyndrome/immunology/prevention&control/KWDtransmissioncervixuteri/cytology/virologyepithelialcells/drugeffects/metabolism/virologyfemalegeneexpression/immunologyhumanhivseronegativityKWDhiv-1lymphocytes/drugeffects/metabolism/KWDvirologymonocytes/drugeffects/metabolism/KWDvirologyproteins/genetics/immunology/KWDpharmacologyrecombinantproteins/pharmacologyrna,messenger/analysisserineproteinaseinhibitors/immunology/KWDpharmacologysupport,non-uKWDsKWDgov'ttightjunctions/metabolism/virology
000930
A0091457

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