Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.

Phytochemistry. 2000 Mar;53(6):689-97. Unique Identifier : AIDSLINE MED/20208671
Zhou P; Takaishi Y; Duan H; Chen B; Honda G; Itoh M; Takeda Y; Kodzhimatov OK; Lee KH; Faculty of Pharmaceutical Sciences, University of Tokushima,; Japan.

Abstract: The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.
Keywords: JOURNAL ARTICLE Anti-HIV Agents/CHEMISTRY/*ISOLATION & PURIF/PHARMACOLOGY Apiaceae/*CHEMISTRY Cell Line Chromatography, High Pressure Liquid Coumarins/CHEMISTRY/*ISOLATION & PURIF/PHARMACOLOGY Cytokines/ANTAGONISTS & INHIB/*METABOLISM Human HIV/DRUG EFFECTS Nuclear Magnetic Resonance Plant Roots/CHEMISTRY Plants, Medicinal/*CHEMISTRYKWDjournalarticleanti-hivagents/chemistry/KWDisolation&purif/pharmacologyapiaceae/KWDchemistrycelllinechromatography,highpressureliquidcoumarins/chemistry/KWDisolation&purif/pharmacologycytokines/antagonists&inhib/KWDmetabolismhumanhiv/drugeffectsnuclearmagneticresonanceplantroots/chemistryplants,medicinal/KWDchemistry
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