Lymphocyte subset abnormalities in multitransfused HIV-negative haemophilia A patients are not due to chronic hepatitis C virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Lymphocyte subset abnormalities in multitransfused HIV-negative haemophilia A patients are not due to chronic hepatitis C virus infection.

Br J Haematol. 2000 Jun;109(3):529-33. Unique Identifier : AIDSLINE MED/20345404
Meijer K; Van Der Meer J; Smit JW; Verspiek SP; Haagsma EB; Smid WM; Division of Thrombosis, Haemostasis and Rheology, University; Hospital Groningen, The Netherlands. k.meijer@int.azg.nl

Abstract: Several abnormalities of immune parameters have been described in HIV-negative haemophiliacs, including changes in numbers of T4 and T8 cells, T4/T8 ratio and numbers of activated T cells. To assess the contribution of hepatitis C to these abnormalities, we compared lymphocyte subsets in 20 HIV-negative HCV-positive haemophilia A patients and in 14 non-haemophiliacs with chronic hepatitis C with those in 18 healthy controls. In haemophilia patients, higher numbers of T lymphocytes and activated T8 cells, lower numbers of B lymphocytes and a normal T4/T8 ratio were seen. These differences were either not demonstrated in hepatitis C controls or were less pronounced and in the opposite direction. We conclude that haemophilia A patients showed abnormalities in lymphocyte subsets that could not be attributed to chronic hepatitis C.
Keywords: JOURNAL ARTICLE Adult B-Lymphocytes/IMMUNOLOGY Blood Transfusion Case-Control Studies Comparative Study CD4-CD8 Ratio Female Hemophilia A/*IMMUNOLOGY/THERAPY Hepatitis C, Chronic/IMMUNOLOGY Human Lymphocyte Count Lymphocyte Subsets/*IMMUNOLOGY Lymphocyte Transformation Male Middle Age T-Lymphocytes/IMMUNOLOGYKWDjournalarticleadultb-lymphocytes/immunologybloodtransfusioncase-controlstudiescomparativestudycd4-cd8ratiofemalehemophiliaa/KWDimmunology/therapyhepatitisc,chronic/immunologyhumanlymphocytecountlymphocytesubsets/KWDimmunologylymphocytetransformationmalemiddleaget-lymphocytes/immunology
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