Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome.

Br J Haematol. 2000 Jun;109(3):540-8. Unique Identifier : AIDSLINE MED/20345407
Roufosse F; Schandene L; Sibille C; Willard-Gallo K; Kennes B; Efira A; Goldman M; Cogan E; Department of Internal Medicine and Immunology, Hopital Erasme,; Universite Libre de Bruxelles, Belgium.

Abstract: Idiopathic hypereosinophilic syndrome (HES) and Gleich's syndrome are related disorders characterized by persistent or recurrent hypereosinophilia of unknown origin. Elevated IgE levels and polyclonal hypergammaglobulinaemia are considered as markers of benign outcome in this setting as they are generally associated with predominant cutaneous manifestations and favourable response to glucocorticoid therapy. In a previous study, we identified a clonal population of CD3-CD4+ Th2-like lymphocytes secreting interleukin (IL)-5 and IL-4 in peripheral blood of a patient fulfilling the diagnostic criteria of HES with associated serum hyper-IgE. We now extend this observation by describing identical findings in three additional patients, and we compare their clinical and biological parameters with five other patients with HES. Chromosomal abnormalities were detected in purified CD3-CD4+ Th2 cells from three patients, among whom one developed anaplastic null cell lymphoma. We therefore suggest that a careful search for T-lymphocyte clonality and cytogenetic changes should be included in the work-up of HES for adequate management.

Keywords: JOURNAL ARTICLE Adult Case-Control Studies Clone Cells Female Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Human Hypereosinophilic Syndrome/*IMMUNOLOGY IgE/BLOOD Immunophenotyping Interleukin-13/ANALYSIS Interleukin-4/ANALYSIS Interleukin-5/ANALYSIS Male Middle Age Polymerase Chain Reaction Support, Non-U.S. Gov't Th2 Cells/*IMMUNOLOGY
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A00A1139

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