Human herpes virus-8 associated with two cases of primary-effusion lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Human herpes virus-8 associated with two cases of primary-effusion lymphoma.

Ann Hematol. 2000 Jun;79(6):336-9. Unique Identifier : AIDSLINE MED/20356793
Niitsu N; Chizuka A; Sasaki K; Umeda M; First Department of Internal Medicine, Toho University School of; Medicine, Tokyo, Japan. nniitsu@med.toho-u.ac.jp

Abstract: Primary-effusion lymphoma (PEL) is a rare form of non-Hodgkin's lymphoma which predominantly occurs in patients with acquired immunodeficiency syndrome and is characterized by the presence of a malignant effusion in one or more of the body cavities, generally in the absence of a primary tumor mass. Recently, we encountered two cases of PEL presenting as cardiac tamponade. In both cases, a diagnosis of diffuse large B-cell lymphoma was made by examination of the pericardial fluid. Because human herpes virus-8 (HHV-8) antibodies were positive and human immunodeficiency virus antibodies were negative, HHV-8 seemed likely to be an etiologic agent for the PEL. One of the two patients (case 1) was not treated for religion reasons and died. The other (case 2) achieved complete remission after treatment using the CHOP regimen and is alive at present. The prognosis of this disease is believed to be poor, therefore more cases should be collected to establish reliable therapy for PEL.
Keywords: JOURNAL ARTICLE Adult Aged Aged, 80 and over Case Report Female Herpesviridae Infections/COMPLICATIONS Herpesvirus, Kaposi Sarcoma-Associated/*ISOLATION & PURIF Human Lymphoma, B-Cell/*VIROLOGY Lymphoma, Large-Cell, Diffuse/COMPLICATIONS/*VIROLOGY MaleKWDjournalarticleadultagedaged,80andovercasereportfemaleherpesviridaeinfections/complicationsherpesvirus,kaposisarcoma-associated/KWDisolation&purifhumanlymphoma,b-cell/KWDvirologylymphoma,large-cell,diffuse/complications/KWDvirologymale
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