Human herpesviruses in primary ocular lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Human herpesviruses in primary ocular lymphoma.

Leuk Lymphoma. 2000 Apr;37(3-4):361-5. Unique Identifier : AIDSLINE MED/20214661
Daibata M; Komatsu T; Taguchi H; Department of Medicine, Kochi Medical School, Japan.; daibatam@kochi-ms.ac.jp

Abstract: Several human lymphotropic herpesviruses have been found in certain lymphoproliferative disorders and implicated as possible etiologic factors or as modulating elements of the diseases. To assess a possible association of the human herpesviruses with lymphomas arising from mucosa-associated lymphoid tissue (MALT), we evaluated the presence of four human herpesviruses, Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), HHV-7, and HHV-8, in the biopsied specimens from 14 patients with primary ocular MALT lymphomas. EBV DNA sequences were detected in four specimens by polymerase chain reaction (PCR), and four cases were positive for HHV-6 DNA. In situ hybridization showed that three and two of 14 cases were positive for EBV mRNA and HHV-6 DNA, respectively. Neither HHV-7 nor HHV-8 sequences could be detected by PCR. These findings would stimulate further investigation as to the involvement of these lymphotropic viruses in the pathogenesis of a subset of low-grade primary ocular lymphomas.
Keywords: JOURNAL ARTICLE Adult Aged Eye Neoplasms/*VIROLOGY Female Herpesviridae/GENETICS/*ISOLATION & PURIF Herpesviridae Infections/*VIROLOGY Herpesvirus 4, Human/GENETICS/ISOLATION & PURIF Herpesvirus 6, Human/GENETICS/ISOLATION & PURIF Herpesvirus 7, Human/GENETICS/ISOLATION & PURIF Herpesvirus, Kaposi Sarcoma-Associated/GENETICS/ISOLATION & PURIF Human In Situ Hybridization Lymphoma, B-Cell/*VIROLOGY Male Middle Age Polymerase Chain Reaction Support, Non-U.S. Gov't Tumor Virus Infections/*VIROLOGYKWDjournalarticleadultagedeyeneoplasms/KWDvirologyfemaleherpesviridae/genetics/KWDisolation&purifherpesviridaeinfections/
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