Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
Association of EBV strains, defined by multiple loci analyses, in non-Hodgkin lymphomas and reactive tissues from HIV positive and HIV negative patients.
Leuk Lymphoma. 2000 Apr;37(3-4):425-9. Unique Identifier : AIDSLINE MED/20214668 Gutierrez MI; Kingma DW; Sorbara L; Tran M; Raffeld M; Jaffe ES; Magrath I; Bhatia K; Lymphoma Biology Section, Pediatric Branch, Division of Clinical; Sciences, National Cancer Institute, NIH, Bethesda, MD, USA.
Abstract:
Epstein-Barr virus (EBV) associated with lymphoid neoplasms demonstrates preferential association with certain viral strains. Previous subtyping studies have however been confined to analysis of sequence variability within a single locus in EBV. Variations have now been reported for several latently expressed EBV genes, including, EBNAs-1, 2 and LMP-1. Variant EBNA-1 strains have been identified in Burkitt's lymphomas and clustering of subtypes for LMP and EBNA-2 have been associated with either malignancy and/or clinical disease. To investigate the linkage between the variability in these three loci in EBV associated with lymphoid malignancies, we subclassified EBV-associated lymphoproliferations (9 reactive and 24 malignant) from HIV-negative and HIV-positive patients by analysis of the EBNA-1, LMP1, and EBNA-2 genes. Our results demonstrate that (1) EBV identical to the prototype B95.8 strain (Type 1 EBNA-2, wild type EBNA-1 and LMP-1) is very rarely associated with tumors. (2) The EBNA-1 variant V-leucine, restricted to malignant lymphomas in immunocompetent patients, was readily identified in non-malignant lesions in HIV infected patients. (3) Variations of EBNA-1 occur independent of variations at other loci.
Keywords: JOURNAL ARTICLE Antigens, Viral/GENETICS Burkitt Lymphoma/GENETICS/VIROLOGY Epstein-Barr Virus Infections/VIROLOGY Epstein-Barr Virus Nuclear Antigens/GENETICS Genetic Markers Genotype Herpesvirus 4, Human/*GENETICS/*ISOLATION & PURIF Human *HIV Seronegativity/GENETICS HIV Seropositivity/GENETICS/*VIROLOGY Lymphoma/*VIROLOGY Lymphoma, Non-Hodgkin/GENETICS/VIROLOGY 001030
A00A1129
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Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
