Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression.

Nat Med. 2000 Jul;6(7):782-9. Unique Identifier : AIDSLINE MED/20348029
Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L; Department of Laboratory of Medicine and Pathobiology, Multi; Organ Transplantation Program, Toronto General Hospital Research; Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada.; lzhang@transplantunit.org

Abstract: Despite increasing evidence for the existence of antigen-specific regulatory T cells, the mechanisms underlying suppression remain unclear. In this study we have identified and cloned a novel subset of antigen-specific regulatory T cells and demonstrated that these T cells possess a unique combination of cell surface markers and array of cytokines. The regulatory T cells are able to inhibit the function of T cells carrying the same T-cell receptor specificity and prevent skin allograft rejection in an antigen-specific, dose-dependent manner. The regulatory T cells are able to acquire alloantigen from antigen-presenting cells, present the alloantigen to activated syngeneic CD8+ T cells and then send death signals to CD8+ T cells. These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression.
Keywords: JOURNAL ARTICLE Animal Antigen Presentation Antigens, CD95 Cell Death CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Graft Survival/IMMUNOLOGY Histocompatibility Antigens Class I/*IMMUNOLOGY Immune Tolerance/*IMMUNOLOGY Mice Mice, Mutant Strains Mice, Transgenic Models, Immunological Signal Transduction Skin Transplantation/*IMMUNOLOGY Spleen/IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocyte Subsets/*IMMUNOLOGYKWDjournalarticleanimalantigenpresentationantigens,cd95celldeathcd4-positivet-lymphocytes/immunologycd8-positivet-lymphocytes/immunologygraftsurvival/immunologyhistocompatibilityantigensclassi/KWDimmunologyimmunetolerance/KWDimmunologymicemice,mutantstrainsmice,transgenicmodels,immunologicalsignaltransductionskintransplantation/KWDimmunologyspleen/immunologysupport,non-uKWDsKWDgov'tt-lymphocytesubsets/KWDimmunology
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