Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
Perception of quality of life of persons with HIV/AIDS and maintenance of nutritional parameters while on protease inhibitors.
AIDS Patient Care STDS. 1999 Jul;13(7):427-33. Unique Identifier : AIDSLINE MED/20328682 Echeverria PS; Jonnalagadda SS; Hopkins BL; Rosenbloom CA; Department of Nutrition, Georgia State University, Atlanta, USA.
Abstract:
This descriptive study investigated quality of life issues, biochemical indices, and nutritional parameters of individuals with HIV/AIDS before the initiation of protease inhibitors (PI) and after PI therapy. Telephone interviews were conducted with 45 men and women who were diagnosed with HIV/AIDS. A 26-item subjective questionnaire was used to determine intake of liquid nutritional supplements, use of micronutrient and herb supplements, adherence to modified diets, gastrointestinal symptoms, employment status, sociability, and ability to conduct activities of daily living. A medical chart review was conducted to collect data on biochemical indices, weight, medication regimens, and incidence of opportunistic infections. The results of the study suggest that HIV/AIDS individuals gain weight, improve CD4 counts, and decrease HIV RNA viral load while on PI-based drug combination therapy. Opportunistic infections decreased, quality of life was improved, and blood albumin was elevated. Hyperlipidemia, that is, elevations in total cholesterol and triglycerides, was observed in study participants (44% and 40% of patients, respectively) after PI therapy. These findings support the need for future investigations to examine the long-term influence of PI-based combination drug therapies on nutrient intake, body composition, and quality of life of persons with HIV/AIDS.
Keywords: JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*DRUG THERAPY/*PSYCHOLOGY Adaptation, Psychological Adult Comparative Study Female Health Surveys Human HIV Infections/DRUG THERAPY/PSYCHOLOGY HIV Protease Inhibitors/*ADMINISTRATION & DOSAGE/ADVERSE EFFECTS Male Middle Age *Nutritional Requirements Patient Participation *Quality of Life Questionnaires Sampling Studies Sick Role 001030
A00A1106
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Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
