Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis.
J Neurovirol. 2000 Apr;6(2):121-6. Unique Identifier : AIDSLINE MED/20284033 Hara T; Yamashita S; Aiba H; Nihei K; Koide N; Good RA; Takeshita K; Department of Pediatrics, Graduate School of Medical Sciences,; Kyushu University, Fukyoka, Fukuoka, Japan.
Abstract:
Live measles virus-specific T helper 1/T helper 2-cytokine productions by peripheral blood mononuclear cells in response to live measles, mumps or varicella virus were measured in 15 patients with subacute sclerosing panencephalitis and 15 controls by enzyme-linked immunosorbent assays. Most patients with subacute sclerosing panencephalitis had a defect in measles virus-specific production of interferon-gamma, one of the T helper 1 type cytokines, despite persistent presence of measles virus, with preserved interleukin-10 (T helper 2 type cytokine) synthesis. Patients with subacute sclerosing panencephalitis were divided into two groups: responders (group A) with significant interferon-gamma production (>20 pg/mL) in response to live measles virus and non-responders (group B) with a little or no interferon-gamma production. Comparison of the clinical courses between groups A and B revealed that all the patients of group A retained receptive function for a long time, while most patients of group B lost the function rapidly (P<0.01). An inverse correlation between interferon-gamma production by peripheral blood mononuclear cells and disease progression suggested that interferon-gamma plays an antiviral role in subacute sclerosing panencephalitis.
Keywords: JOURNAL ARTICLE Adolescence Adult Chickenpox Vaccine/IMMUNOLOGY Child Child, Preschool Comparative Study Disease Progression Enzyme-Linked Immunosorbent Assay Female Human Immunity, Cellular Interferon Type II/BIOSYNTHESIS/DEFICIENCY/*PHYSIOLOGY/SECRETION Interleukins/BIOSYNTHESIS/SECRETION Lymphokines/*BIOSYNTHESIS/SECRETION Male Measles Vaccine/*IMMUNOLOGY Measles Virus/*IMMUNOLOGY/PATHOGENICITY Mumps Vaccine/IMMUNOLOGY Subacute Sclerosing Panencephalitis/*IMMUNOLOGY/VIROLOGY Support, Non-U.S. Gov't Th1 Cells/*SECRETION Th2 Cells/*SECRETION Vaccines, Attenuated/IMMUNOLOGY 001030
A00A1094
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Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
