CD8(+) T cells secreting type 2 lymphokines are defective in protection against viral infection. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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CD8(+) T cells secreting type 2 lymphokines are defective in protection against viral infection.

Cell Immunol. 2000 May 25;202(1):13-22. Unique Identifier : AIDSLINE MED/20334541
Wirth S; van den Broek M; Frossard CP; Hugin AW; Leblond I; Pircher H; Hauser C; Allergy Unit, Division of Immunology and Allergy, Hopital; Cantonal Universitaire, Geneva, Switzerland.

Abstract: Effector T cells secreting type 1 and/or type 2 lymphokines (Tc1, Tc0, Tc2) were generated in vitro from CD8(+) T cells of mice with a transgenic TCR recognizing lymphocytic choriomeningitis virus (LCMV) glycoprotein to compare their effector function in vitro and in vivo. Tc1, Tc2, and Tc0 showed similar Fas- and perforin-mediated cytotoxicity in vitro. Upon adoptive transfer, Tc2 and Tc0 effectors were less efficient than Tc1 at controlling LCMV or recombinant vaccinia virus expressing the LCMV glycoprotein in vivo. Tc2 and Tc0 had decreased surface VLA-4 density and deficient activation-induced LFA-1/ICAM-1-dependent homotypic adhesion in vitro. Therefore, the reduced antiviral activity in vivo of Tc2 and Tc0 compared with Tc1 is not due to reduced cytotoxic activity or IFN-gamma secretion but may be explained by defective homing to the target organ due to decreased expression and/or lower activity of adhesion molecules. Copyright 2000 Academic Press.
Keywords: JOURNAL ARTICLE Adoptive Transfer Animal Chemotaxis, Leukocyte Cytotoxicity Tests, Immunologic CD8-Positive T-Lymphocytes/*VIROLOGY Integrins Intercellular Adhesion Molecule-1 Interleukin-4/SECRETION Interleukin-5/SECRETION Lymphocyte Function-Associated Antigen-1 Lymphocytic Choriomeningitis Virus/*IMMUNOLOGY Lymphokines/*SECRETION Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Antigen, T-Cell/GENETICS Receptors, Lymphocyte Homing Support, Non-U.S. Gov'tKWDjournalarticleadoptivetransferanimalchemotaxis,leukocytecytotoxicitytests,immunologiccd8-positivet-lymphocytes/KWDvirologyintegrinsintercellularadhesionmolecule-1interleukin-4/secretioninterleukin-5/secretionlymphocytefunction-associatedantigen-1lymphocyticchoriomeningitisvirus/KWDimmunologylymphokines/KWDsecretionmicemice,inbredc57blmice,transgenicreceptors,antigen,t-cell/geneticsreceptors,lymphocytehomingsupport,non-uKWDsKWDgov't
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