Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice.
Cell Immunol. 2000 May 25;202(1):61-9. Unique Identifier : AIDSLINE MED/20334546 Naiki Y; Nishimura H; Itohara S; Yoshikai Y; Laboratory of Host Defense and Germ-free Life, Nagoya University; School of Medicine, Nagoya, 466-0053, Japan.
Abstract:
To investigate the roles of gammadelta T cells in Salmonella infection, we examined the resolution of an intraperitoneal infection with avirulent Salmonella choleraesuis 31N-1 in mice lacking T-cell-receptor (TCR) alphabeta T cells by disruption of the TCRbeta chain gene (TCRbeta(-/-)). The bacteria in TCRbeta(-/-) mice decreased with kinetics similar to that seen in control mice (TCRbeta(+/+)) after infection. The number of natural killer (NK) cells in the peritoneal cavity increased on day 6 after infection and thereafter decreased in both TCRbeta(-/-) and TCRbeta(+/+) mice, whereas the number of gammadelta T cells, in place of alphabeta T cells, increased remarkably in the peritoneal cavity of TCRbeta(-/-) mice on day 6 after infection. The NK cells from Salmonella-infected TCRbeta(-/-) mice produced interferon-gamma (IFN-gamma) but neither interleukin-4 (IL-4) nor IL-13 in response to immobilized anti-NK1.1 monoclonal antibody (mAb). The gammadelta T cells produced IFN-gamma but neither IL-4 nor IL-13 in response to heat-killed Salmonella, whereas both IFN-gamma and IL-13 but no IL-4 was produced by the gammadelta T cells stimulated with immobilized anti-TCRgammadelta mAb. In vivo administration of anti-NK1.1 mAb inhibited the reduction of Salmonella, whereas anti-TCRgammadelta mAb treatment did not affect the bacterial growth in TCRbeta(-/-) mice after Salmonella infection. However, neutralization of endogenous IL-13 with anti-IL-13 mAb enhanced the bacterial clearance in TCRbeta(-/-) mice after infection. These results suggest that NK1.1(+) cells serve mainly to protect against avirulent Salmonella infection in the absence of alphabeta T cells, whereas gammadelta T cells may play dichotomous roles in Salmonella infection through IFN-gamma and IL-13 in TCRbeta(-/-) mice. Copyright 2000 Academic Press.
Keywords: JOURNAL ARTICLE Animal Antigens Exudates and Transudates Female Genes, T-Cell Receptor beta Interferon Type II/*IMMUNOLOGY Interleukin-13/*IMMUNOLOGY Mice Mice, Inbred C57BL Mice, Mutant Strains Peritoneum/IMMUNOLOGY Proteins *Receptors, Antigen, T-Cell, gamma-delta/GENETICS Salmonella/*PATHOGENICITY Salmonella Infections, Animal/*IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocyte Subsets/*IMMUNOLOGY Th1 Cells/IMMUNOLOGY Th2 Cells/IMMUNOLOGY 001030
A00A1083
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Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
