Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
Most env and gag subtype A HIV-1 viruses circulating in West and West Central Africa are similar to the prototype AG recombinant virus IBNG.
J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):363-74. Unique Identifier : AIDSLINE + Montavon C; Toure-Kane C; Liegeois F; Mpoudi E; Bourgeois A; Vergne L; Perret JL; Boumah A; Saman E; Mboup S; Delaporte E; Peeters M; Laboratoire Retrovirus, Institut pour la Recherche en; Developement, Montpellier, France.
Abstract:
The genetic subtype was identified in gag and env of 219 HIV-1-positive samples collected in different African countries, 44 from Senegal, 55 from Cameroon, 82 from Gabon, and 38 from Djibouti. In total, 20 (9.1%) samples had discordant subtypes between gag and env, 6 of 44 (13.9%) in Senegal, 4 of 55 (7.2%) in Cameroon, 1 of 38 (2.6%) in Djibouti, and 10 of 82 (12.1%) in Gabon. Subtypes A and G were predominantly involved in the recombination events. Phylogenetic tree analysis of gag showed that an important number of the A sequences form a distinct subcluster with the AG-IBNG prototype strain (a complex A/G mosaic virus): 27 of 32 (84.3%) in Senegal, 12 of 17 (70.6%) in Nigeria, 24 of 39 (61.5%) in Cameroon, and 38 of 70 (54.3%) in Gabon. Full-length genome analysis of 3 and additional sequences in pol for 10 such strains confirmed that they have a similar complex A/G mosaic genomic structure. These data suggest that in West Africa, most probably between 60% and 84% of the subtype A viruses are recombinant AG-IBNG viruses. This finding has potential implications on future vaccine, diagnostic, and treatment strategies. The actual and future role of these viruses in the global pandemic must be monitored in all new molecular epidemiologic studies, a discrimination between subtype A and AG-IBNG-like viruses is necessary.
Keywords: JOURNAL ARTICLE Amino Acid Sequence Base Sequence Cameroon/EPIDEMIOLOGY Djibouti/EPIDEMIOLOGY DNA, Viral Gabon/EPIDEMIOLOGY Genome, Viral Human HIV Core Protein p24/CLASSIFICATION/*GENETICS HIV Envelope Protein gp120/CLASSIFICATION/*GENETICS HIV Infections/BLOOD/EPIDEMIOLOGY/*VIROLOGY HIV Protease/GENETICS HIV-1/CLASSIFICATION/*GENETICS HIV-1 Reverse Transcriptase/GENETICS Molecular Sequence Data Peptide Fragments/CLASSIFICATION/*GENETICS Phylogeny Prevalence *Recombination, Genetic Senegal/EPIDEMIOLOGY Support, Non-U.S. Gov't 001030
A00A1072
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Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
