HAART is neuroprophylactic in HIV-1 infection.

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

HAART is neuroprophylactic in HIV-1 infection.

J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):380-5. Unique Identifier : AIDSLINE MED/20322599
von Giesen HJ; Hefter H; Jablonowski H; Arendt G; Department of Neurology, Heinrich Heine University, Dusseldorf,; Germany. giesenhj@uni-duesseldorf.de

Abstract: BACKGROUND: To find out about the prophylactic value of antiretroviral therapy on HIV-1-associated subclinical and clinical psychomotor slowing as one marker of HIV-1-associated CNS disease. METHODS: Prospective study with regular clinical and neurophysiologic examination every three months of 1482 consecutive HIV-1-seropositive and AIDS patients seen at our department till June 30, 1999. RESULTS: Antiretroviral therapy has a significant prophylactic value over an individual observation period of ten years with regard to the first, potentially transient manifestation of HIV-1-associated subclinical psychomotor slowing and with regard to the clinical manifestation of motor signs. However, a subgroup of patients is characterized through a second, more sustained manifestation of subclinical psychomotor slowing which cannot be prevented by any type of currently available antiretroviral therapy. CONCLUSIONS: These findings suggest the existence of different pathomechanisms underlying HIV-1-associated brain disease which may in part be effectively prevented, but which in part also escape all antiretroviral treatment strategies in use today.

Keywords: JOURNAL ARTICLE Anti-HIV Agents/*THERAPEUTIC USE Drug Therapy, Combination Female Human HIV Infections/COMPLICATIONS/*DRUG THERAPY/PHYSIOPATHOLOGY HIV-1/*PHYSIOLOGY Male Prospective Studies Psychomotor Disorders/ETIOLOGY/*PREVENTION & CONTROL/ PHYSIOPATHOLOGY
001030
A00A1070

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