Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
Clinical prediction model for differentiation of disseminated Histoplasma capsulatum and Mycobacterium avium complex infections in febrile patients with AIDS.
J Acquir Immune Defic Syndr. 2000 May 1;24(1):30-6. Unique Identifier : AIDSLINE MED/20334003 Graviss EA; Vanden Heuvel EA; Lacke CE; Spindel SA; White AC Jr; Hamill RJ; Section of Infectious Diseases, Veterans Affairs Medical Center,; Houston, Texas 77030-4211, USA.
Abstract:
BACKGROUND: Disseminated infection with Histoplasma capsulatum and Mycobacterium avium complex (MAC) in patients with AIDS are frequently difficult to distinguish clinically. METHODS: We retrospectively compared demographic information, other opportunistic infections, medications, symptoms, physical examination findings and laboratory parameters at the time of hospital presentation for 32 patients with culture documented disseminated histoplasmosis and 58 patients with disseminated MAC infection. RESULTS: Positive predictors of histoplasma infection by univariate analysis included lactate dehydrogenase level, white blood cell (WBC) count, platelet count, alkaline phosphatase level, and CD4 cell count. By multivariate logistic regression analysis, those characteristics that remained significant included a lactate dehydrogenase value > or =500 U/L (risk ratio [RR], 42; 95% confidence interval [CI], 18.53-97.5; p < .001), alkaline phosphatase < or =300 U/L (RR, 9.35; 95% CI, 2.61-33.48; p = .008), WBC < or =4.5 x 10(6)/L (RR, 21.29; 95% CI, 6.79-66.75; p = .008), and CD4 cell count (RR, 0.958; 95% CI, 0.946-0.971; p = .001). CONCLUSIONS: A predictive model for distinguishing disseminated histoplasmosis from MAC infection was developed using lactate dehydrogenase and alkaline phosphatase levels as well as WBC count. This model had a sensitivity of 83%, a specificity of 91%, and a misclassification rate of 13%.
Keywords: JOURNAL ARTICLE Adult Alkaline Phosphatase AIDS-Related Opportunistic Infections/*PHYSIOPATHOLOGY CD4 Lymphocyte Count Female Fever/*PHYSIOPATHOLOGY Histoplasma Histoplasmosis/*PHYSIOPATHOLOGY Human Lactate Dehydrogenase Leukocyte Count Male Models, Biological Mycobacterium avium Complex Mycobacterium avium-intracellulare Infection/*PHYSIOPATHOLOGY Predictive Value of Tests Retrospective Studies Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. 001030
A00A1055
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Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
