2000
- 2',3'-Didehydro-3'-deoxythymidine N-methyl-2-pyrrolidone solvate (D4T.NMPO).
- Acta Crystallogr C. 2000 May;56 ( Pt 5):580-1. Unique Identifier : AIDSLINE MED/20310174
- Viterbo D; Milanesio M; Pomez Hernandez R; Rodriquez Tanty C; Colas Gonzalez I; Sablon Carrazana M; Duque Rodriguez J; Dipartimento di Scienze e Tecnologie Avanzate, Universita del; Piemonte Orientale A. Avogadro, Alessandria, Italy.; viterbo@ch.unito.it
- Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
- Phytochemistry. 2000 Mar;53(6):689-97. Unique Identifier : AIDSLINE MED/20208671
- Zhou P; Takaishi Y; Duan H; Chen B; Honda G; Itoh M; Takeda Y; Kodzhimatov OK; Lee KH; Faculty of Pharmaceutical Sciences, University of Tokushima,; Japan.
- The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the is
- Drug treatment of HIV associated neuropsychiatric syndromes.
- Neurologia. 2000 Apr;15(4):164-71. Unique Identifier : AIDSLINE MED/20306239
- Ayuso Mateos JL; Singh AN; Catalan J; Clinical and Social Psychiatry Research Unit, Hospital; Universitario Marques de Valdecilla, Universidad de Cantabria,; Santander. ayusoj@medi.unican.es
- Psychotropic drugs are frequently used to treat the wide range of neuropsychiatric syndromes that patients infected with the human immunodeficiency virus (HIV) may develop. In order to administer these agents properly, physicians should take into account, among other factors, that: the central nervous system (CNS) of
- Do people attending a same day testing clinic discuss their need for a HIV test with their GP?
- Br J Gen Pract. 1999 Oct;49(447):813-5. Unique Identifier : AIDSLINE MED/20343501
- Madge S; Jones M; Mocroft A; Wells H; Johnson MA; Department of Thoracic Medicine, Royal Free Hospital, London.
- In the United Kingdom , people with HIV infection present with advanced disease and general practitioners (GPs) are currently an underused resource for HIV testing. We describe the reasons for using an open-access clinic rather than primary care for testing for HIV. People attending the
- [HIV-related thrombocytopenias]
- Ann Ital Med Int. 2000 Jan-Mar;15(1):20-7. Unique Identifier : AIDSLINE MED/20301705
- Mannucci PM; Gringeri A; Dipartimento di Medicina Interna, Centro Emofilia e Trombosi; Angelo Bianchi Bonomi, Universita degli Studi di Milano.; piermannuccio.mannucci@unimi.it
- Thrombocytopenia is a relatively frequent hematological complication in patients infected with the human immunodeficiency virus type 1. Occurring in all risk groups (homosexuals, intravenous drug addicts, hemophiliacs, heterosexuals) this complication has an overall prevalence varying between 5 and 15%. Only a relativ
- Lymphocyte subset abnormalities in multitransfused HIV-negative haemophilia A patients are not due to chronic hepatitis C virus infection.
- Br J Haematol. 2000 Jun;109(3):529-33. Unique Identifier : AIDSLINE MED/20345404
- Meijer K; Van Der Meer J; Smit JW; Verspiek SP; Haagsma EB; Smid WM; Division of Thrombosis, Haemostasis and Rheology, University; Hospital Groningen, The Netherlands. k.meijer@int.azg.nl
- Several abnormalities of immune parameters have been described in HIV-negative haemophiliacs, including changes in numbers of T4 and T8 cells, T4/T8 ratio and numbers of activated T cells. To assess the contribution of hepatitis C to these abnormalities, we compared lymphocyte subsets in 20 HIV-negative HCV-positive h
- Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome.
- Br J Haematol. 2000 Jun;109(3):540-8. Unique Identifier : AIDSLINE MED/20345407
- Roufosse F; Schandene L; Sibille C; Willard-Gallo K; Kennes B; Efira A; Goldman M; Cogan E; Department of Internal Medicine and Immunology, Hopital Erasme,; Universite Libre de Bruxelles, Belgium.
- Idiopathic hypereosinophilic syndrome (HES) and Gleich s syndrome are related disorders characterized by persistent or recurrent hypereosinophilia of unknown origin. Elevated IgE levels and polyclonal hypergammaglobulinaemia are considered as markers of benign outcome in this setting as they are generally associated w
- Essential role for T cells in human B-cell lymphoproliferative disease development in severe combined immunodeficient mice.
- Br J Haematol. 2000 Jun;109(3):600-10. Unique Identifier : AIDSLINE MED/20345415
- Johannessen I; Asghar M; Crawford DH; Department of Medical Microbiology, The University of Edinburgh; Medical School, UK.
- Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease (BLPD)-like lesions develop in severe combined immunodeficient (SCID) mice inoculated with peripheral blood mononuclear cells (PBMCs) from EBV-seropositive donors. We used this model to investigate the pathogenesis of EBV-associated BLPD. Tumour inci
- Absence of human herpesvirus 8 DNA sequences in leucapheresis products and bone marrow samples Of patients with advanced multiple myeloma [letter; comment]
- Br J Haematol. 2000 Jun;109(3):676-7. Unique Identifier : AIDSLINE MED/20345434
- Beck R; Neipel F; Canji B; Hebart H; Kanz L; Jahn G; Einsele H
- Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide.
- Bioconjug Chem. 2000 May-Jun;11(3):301-5. Unique Identifier : AIDSLINE MED/20281353
- Bhorade R; Weissleder R; Nakakoshi T; Moore A; Tung CH; Center for Molecular Imaging Research, Massachusetts General; Hospital, Harvard Medical School, 149 13th St., #5406,; Charlestown, Massachusetts 02129, USA.
- A major obstacle to using paramagnetic MR contrast agents for in vivo cell tracking or molecular sensing is their generally low cellular uptake. In this study, we show that a paramagnetically labeled DOTA chelator derivatized with a 13-mer HIV-tat peptide is efficiently internalized into mammalian cells. Intracellular
- The stability of intracellular zidovudine and its anabolites in extracts of peripheral blood mononuclear cells (PBMCs).
- J Pharm Biomed Anal. 2000 Apr;22(3):597-603. Unique Identifier : AIDSLINE MED/20227443
- Thevanayagam LN; Jayewardene AL; Gambertoglio JG; Department of Clinical Pharmacy, School of Pharmacy, University; of California, San Francisco 94143-0622, USA.
- Human herpes virus-8 associated with two cases of primary-effusion lymphoma.
- Ann Hematol. 2000 Jun;79(6):336-9. Unique Identifier : AIDSLINE MED/20356793
- Niitsu N; Chizuka A; Sasaki K; Umeda M; First Department of Internal Medicine, Toho University School of; Medicine, Tokyo, Japan. nniitsu@med.toho-u.ac.jp
- Primary-effusion lymphoma (PEL) is a rare form of non-Hodgkin s lymphoma which predominantly occurs in patients with acquired immunodeficiency syndrome and is characterized by the presence of a malignant effusion in one or more of the body cavities, generally in the absence of a pr
- Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children.
- Nutrition. 2000 Jun;16(6):447-53. Unique Identifier : AIDSLINE MED/20329813
- Decsi T; Koletzko B; Division of Metabolic Disorders and Nutrition, Department of; Pediatrics, Dr. von Haunersches Kinderspital, Ludwig-Maximilians; University, Munich, Germany.
- This report summarizes data on the availability of essential fatty acids (EFAs) and their long-chain polyunsaturated fatty acid (LCPUFA) metabolites in protein-energy malnutrition (PEM), in human immunodeficiency virus-1 (HIV-1) infection for which less information is available, and the combination of both PEM and HIV
- [Compared characteristics of peripheral facial paralysis according to HIV status in Bobo-Dioulasso (Burkina Faso)]
- Bull Soc Pathol Exot. 2000 Apr;93(2):104-7. Unique Identifier : AIDSLINE MED/20321951
- Millogo A; Ki-Zerbo GA; Sawadogo AB; Ouedraogo I; Tamini MM; Service de medecine interne, Centre hospitalier national Souro; Sanou, Burkina Faso. athanase_millogo@hotmail.com
- Facial paralysis is a well-described manifestation of HIV infection. We report 27 cases of peripheral facial paralysis observed at Bobo-Dioulasso Hospital in a prospective study over a period of 9 months: 55 of the cases were HIV positive and 12/15 (80%) were in the 20-39 age group. Nine out of 11 females and 6 out of
- Estimating the prevalence of problem drug use in inner London: a discussion of three capture-recapture studies.
- Addiction. 1999 Nov;94(11):1653-62. Unique Identifier : AIDSLINE MED/20349926
- Hickman M; Cox S; Harvey J; Howes S; Farrell M; Frischer M; Stimson G; Taylor C; Tilling K; Centre for Research on Drugs and Health Behaviour, Imperial; College School of Medicine, London, UK. m.hickman@ic.ac.uk
- AIMS: To provide an evidence base of estimates of the prevalence of problem drug use in inner London. DESIGN: Re-analysis of three capture-recapture studies using subjects aged 15-49 years, that aim to estimate the hidden population from analysing the overlaps between three data sources. SETTING: Newham (1995) Camden
- Human herpesviruses in primary ocular lymphoma.
- Leuk Lymphoma. 2000 Apr;37(3-4):361-5. Unique Identifier : AIDSLINE MED/20214661
- Daibata M; Komatsu T; Taguchi H; Department of Medicine, Kochi Medical School, Japan.; daibatam@kochi-ms.ac.jp
- Several human lymphotropic herpesviruses have been found in certain lymphoproliferative disorders and implicated as possible etiologic factors or as modulating elements of the diseases. To assess a possible association of the human herpesviruses with lymphomas arising from mucosa-associated lymphoid tissue (MALT), we
- Association of EBV strains, defined by multiple loci analyses, in non-Hodgkin lymphomas and reactive tissues from HIV positive and HIV negative patients.
- Leuk Lymphoma. 2000 Apr;37(3-4):425-9. Unique Identifier : AIDSLINE MED/20214668
- Gutierrez MI; Kingma DW; Sorbara L; Tran M; Raffeld M; Jaffe ES; Magrath I; Bhatia K; Lymphoma Biology Section, Pediatric Branch, Division of Clinical; Sciences, National Cancer Institute, NIH, Bethesda, MD, USA.
- Epstein-Barr virus (EBV) associated with lymphoid neoplasms demonstrates preferential association with certain viral strains. Previous subtyping studies have however been confined to analysis of sequence variability within a single locus in EBV. Variations have now been reported for several latently expressed EBV gene
- Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma.
- Am J Respir Crit Care Med. 2000 Jun;161(6):1790-6. Unique Identifier : AIDSLINE MED/20311398
- Magnan AO; Mely LG; Camilla CA; Badier MM; Montero-Julian FA; Guillot CM; Casano BB; Prato SJ; Fert V; Bongrand P; Vervloet D; UPRES 2050, Groupe de Recherche Clinique "Pathologie respiratoire; et cutanee liee a l'environnement," Service de; Pneumo-Allergologie, et Centre d'Investigations Cliniques,; INSERM, Assistance Publique Hopitaux de Marseille, France.; amagnan@mail.ap-hm.fA
- Atopy is characterized by an immune system that is biased to T helper cell, type 2 (Th2) activation. This condition predisposes to asthma, a disease in which a Th2 activation was found in blood and lungs. However, most blood studies have considered purified cells, which might give an incomplete view of immune reaction
- New therapies for heart failure: is thalidomide the answer?
- QJM. 2000 May;93(5):305-11. Unique Identifier : AIDSLINE MED/20286658
- Davey PP; Ashrafian H; Nuffield Department of Medicine, Oxford University, John; Radcliffe Hospital, Oxford, UK. patrick.davey@ndm.ox.ac.uk
- The syndrome of advanced heart failure is associated with considerable morbidity and mortality. Ideas about the reasons for the progressive nature of the heart failure syndrome have changed over the years, with the initial view that progression was principally due to pump failure (the haemodynamic hypothesis), givin
- Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo.
- Immunity. 2000 Jun;12(6):643-52. Unique Identifier : AIDSLINE MED/20350662
- Agarwal S; Avni O; Rao A; Department of Pathology, Harvard Medical School and the Center; for Blood Research, Boston, Massachusetts 02115, USA.
- By DNase I hypersensitivity analysis, we have identified an inducible, cyclosporin A-sensitive enhancer located 3 of the interleukin-4 (IL-4) gene. The enhancer binds the Th2-specific transcription factor GATA3 in vivo but is not perceptibly influenced by the absence of a second Th2-specific factor, cMaf. The antigen
- Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States.
- J Viral Hepat. 2000 May;7(3):196-202. Unique Identifier : AIDSLINE MED/20307922
- Blatt LM; Mutchnick MG; Tong MJ; Klion FM; Lebovics E; Freilich B; Bach N; Smith C; Herrera J; Tobias H; Conrad A; Schmid P; McHutchison JG; National Genetics Institute, Los Angeles, CA, USA.
- Hepatitis C virus (HCV) RNA status and HCV genotype have become important tools in the diagnosis and monitoring of therapy in chronic HCV infection. To establish a database with respect to HCV genotype and serum HCV RNA concentrations in chronic hepatitis C patients in the United States
- Comparison between three quantitative assays in patients with chronic hepatitis C and their relevance in the prediction of response to therapy.
- J Viral Hepat. 2000 May;7(3):203-10. Unique Identifier : AIDSLINE MED/20307923
- Pradat P; Chossegros P; Bailly F; Pontisso P; Saracco G; Sauleda S; Thursz M; Tillmann H; Vlassopoulou H; Alberti A; Braconier JH; Esteban JI; Hadziyannis S; Manns M; Rizzetto M; Thomas HC; Tr:epo C; Department of Hepatology, H^otel-Dieu, Lyon, France.
- To compare three quantitative assays measuring viral load in patients with chronic hepatitis C and to determine their value in predicting response to interferon (IFN) therapy, we analysed serum from 896 patients from eight European Centres using QUANTIPLEXtrade mark bDNA, MONITOR AMPLICORtrade mark and SUPERQUANTtrade
- Pretreatment symptoms and dosing regimen predict side-effects of interferon therapy for hepatitis C.
- J Viral Hepat. 2000 May;7(3):211-7. Unique Identifier : AIDSLINE MED/20307924
- Cotler SJ; Wartelle CF; Larson AM; Gretch DR; Jensen DM; Carithers Jr RL; RUSH-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612,; USA. scotler@rush.edu
- We analysed data from a multicentre interferon (IFN) treatment trial to evaluate symptoms in patients with chronic hepatitis C and to identify factors that might predict development of debilitating IFN side-effects. Two hundred and twenty-two patients (120 US, 102 French) received 3 or 5 million units (MU) of IFN-alph
- Interferon treatment with or without oral ganciclovir in HBeAg-negative chronic hepatitis B: a randomized study.
- J Viral Hepat. 2000 May;7(3):235-40. Unique Identifier : AIDSLINE MED/20307928
- Hadziyannis S; Alexopoulou A; Papakonstantinou A; Petraki K; Manesis E; Academic Department of Medicine, Hippokration General Hospital,; Athens, Greece. hadziyannis@ath.forthnet.gr
- The treatment of HBeAg-negative chronic hepatitis B with alpha interferon alone is unsatisfactory. We evaluated the efficacy of combined administration of interferon-a2a (IFN) with oral ganciclovir, a nucleoside analogue. Forty patients with hepatitis B virus (HBV)-DNA-positive/HBeAg-negative chronic hepatitis B, were
- Industry outlines its perspective on new third-world vaccine development [news]
- Nat Med. 2000 Jul;6(7):723-4. Unique Identifier : AIDSLINE MED/20348001
- Birmingham K
- Beanie Baby profits support AIDS foundation [news]
- Nat Med. 2000 Jul;6(7):726. Unique Identifier : AIDSLINE MED/20348007
- WHO under attack on HIV drug policy [news]
- Nat Med. 2000 Jul;6(7):726. Unique Identifier : AIDSLINE MED/20348009
- Watanabe ME
- Taking aim at HIV replication [news; comment]
- Nat Med. 2000 Jul;6(7):735-6. Unique Identifier : AIDSLINE MED/20348013
- Finzi D; Siliciano RF
- HIV-1 rebound after anti-retroviral therapy [news; comment]
- Nat Med. 2000 Jul;6(7):736-7. Unique Identifier : AIDSLINE MED/20348014
- Ho DD; Zhang L
- Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy [see comments]
- Nat Med. 2000 Jul;6(7):757-61. Unique Identifier : AIDSLINE MED/20348025
- Chun TW; Davey RT Jr; Ostrowski M; Shawn Justement J; Engel D; Mullins JI; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. twchun@nih.gov
- We examined the pathogenic significance of the latent viral reservoir in the resting CD4+ T cell compartment of HIV-1-infected individuals as well as its involvement in the rebound of plasma viremia after discontinuation of highly active anti-retroviral therapy (HAART). Using heteroduplex mobility and tracking assays,
- Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo [see comments]
- Nat Med. 2000 Jul;6(7):762-8. Unique Identifier : AIDSLINE MED/20348026
- Chapuis AG; Paolo Rizzardi G; D'Agostino C; Attinger A; Knabenhans C; Fleury S; Acha-Orbea H; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Department of Medicine,; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, University of Lausanne, 1011 Lausanne, Switzerland.
- Mycophenolic acid, a selective inhibitor of the de novo synthesis of guanosine nucleotides in T and B lymphocytes, has been proposed to inhibit human immunodeficiency virus (HIV) replication in vitro by depleting the substrate (guanosine nucleotides) for reverse transcriptase. Here we show that mycophenolic acid induc
- Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection.
- Nat Med. 2000 Jul;6(7):769-75. Unique Identifier : AIDSLINE MED/20348027
- Mack M; Kleinschmidt A; Bruhl H; Klier C; Nelson PJ; Cihak J; Plachy J; Stangassinger M; Erfle V; Schlondorff D; Medical Policlinic, Ludwig-Maximilians-University,; Pettenkoferstrasse 8a, 80336 Munich, Germany.
- The release of microparticles from eukaryotic cells is a well-recognized phenomenon. We demonstrate here that the chemokine receptor CCR5, the principal co-receptor for macrophage-tropic human immunodeficiency virus (HIV)-1, can be released through microparticles from the surface of CCR5+ Chinese hamster ovary cells a
- Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression.
- Nat Med. 2000 Jul;6(7):782-9. Unique Identifier : AIDSLINE MED/20348029
- Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L; Department of Laboratory of Medicine and Pathobiology, Multi; Organ Transplantation Program, Toronto General Hospital Research; Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada.; lzhang@transplantunit.org
- Despite increasing evidence for the existence of antigen-specific regulatory T cells, the mechanisms underlying suppression remain unclear. In this study we have identified and cloned a novel subset of antigen-specific regulatory T cells and demonstrated that these T cells possess a unique combination of cell surface
- [Complex regional pain syndrome: the need for multidisciplinary approach]
- Rev Neurol. 2000 Mar 16-31;30(6):555-61. Unique Identifier : AIDSLINE MED/20322068
- de la Calle-Reviriego JL; Unidad para el Estudio y Tratamiento del Dolor, Hospital Ramon y; Cajal, Madrid, Espana.
- INTRODUCTION AND DEVELOPMENT: The title complex regional pain syndrome is being introduced to cover the painful syndromes which formerly were described under the headings reflex sympathetic dystrophy and causalgia. The pain may be sympathetically maintained or sympathetically independent. The incidence of disease with
- AIDS and lipodystrophy: complications of HIV and HIV treatments [editorial]
- AIDS Patient Care STDS. 1999 Jul;13(7):389-90. Unique Identifier : AIDSLINE MED/20328677
- Laurence J
- Short-term human growth hormone therapy for HIV-associated wasting [letter]
- AIDS Patient Care STDS. 1999 Jul;13(7):391-3. Unique Identifier : AIDSLINE MED/20328678
- Nemechek PM
- Altered body shape in HIV disease: a side effect of therapy?
- AIDS Patient Care STDS. 1999 Jul;13(7):395-402. Unique Identifier : AIDSLINE MED/20328679
- Baker R; Kotler D; Carr A; Torres RA; Department of Medicine, St. Luke's-Roosevelt Hospital, New York,; New York, USA. ronbaker@pacbell.net
- An interactive teleconference on HIV-associated lipodystrophies and altered body habitus was held on January 20, 1999, part of a series known as HIV Treatment LIVE!. It was moderated by Ronald Baker, Ph.D., and sponsored by the AIDS Wasting Foundation (AWF). AWF, located at 15 East 26th Street, New York, NY 10010, was
- Willingness to treat HIV-positive patients at different stages of medical education and experience.
- AIDS Patient Care STDS. 1999 Jul;13(7):403-14. Unique Identifier : AIDSLINE MED/20328680
- Radecki S; Shapiro J; Thrupp LD; Gandhi SM; Sangha SS; Miller RB; Pacific AIDS Education and Training Center, University of; Southern California School of Medicine, Los Angeles, USA.; sradecki@hsc.usc.edu
- The willingness of physicians to provide care to HIV-positive patients has been linked to a number of attitudinal factors, but little is known concerning the impact of premedical, medical, and residency training on these factors. The purpose of this study is to elicit responses to the same series of questions concerni
- Pathogenesis of non-AIDS-defining cancers: a review.
- AIDS Patient Care STDS. 1999 Jul;13(7):415-26. Unique Identifier : AIDSLINE MED/20328681
- Wistuba II; Behrens C; Gazdar AF; Hamon Center for Therapeutic Oncology Research, University of; Texas Southwestern Medical Center, Dallas, USA.
- As the AIDS epidemic advances, the number of HIV-infected subjects developing AIDS-related neoplasms is rapidly increasing, and the spectrum of malignancies encountered is expanding. Several non-AIDS-defining cancers are being reported at an increasing incidence in HIV-infected individuals, including anal, skin, oral
- Perception of quality of life of persons with HIV/AIDS and maintenance of nutritional parameters while on protease inhibitors.
- AIDS Patient Care STDS. 1999 Jul;13(7):427-33. Unique Identifier : AIDSLINE MED/20328682
- Echeverria PS; Jonnalagadda SS; Hopkins BL; Rosenbloom CA; Department of Nutrition, Georgia State University, Atlanta, USA.
- This descriptive study investigated quality of life issues, biochemical indices, and nutritional parameters of individuals with HIV/AIDS before the initiation of protease inhibitors (PI) and after PI therapy. Telephone interviews were conducted with 45 men and women
- HIV/AIDS case histories: diagnostic problems. So-called "bone marrow pattern of AIDS".
- AIDS Patient Care STDS. 1999 Jul;13(7):435-6. Unique Identifier : AIDSLINE MED/20328683
- Godwin JH; New York Presbyterian Hospital-Weill Medical College, New York,; USA.
- Soft-gel Norvir [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):437. Unique Identifier : AIDSLINE MED/20328684
- Viagra reacts with ritonavir [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):437. Unique Identifier : AIDSLINE MED/20328685
- Amprenavir approved [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):438. Unique Identifier : AIDSLINE MED/20328687
- Monoclonal antibody has efficacy against HIV [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):438. Unique Identifier : AIDSLINE MED/20328686
- 48-week data released for combination treatment with efavirenz [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):438-40. Unique Identifier : AIDSLINE MED/20328688
- Substances may help women [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):442. Unique Identifier : AIDSLINE MED/20328694
- Patient education CD-ROM available [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):442-3. Unique Identifier : AIDSLINE MED/20328696
- Local production of condoms encouraged [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):443-4. Unique Identifier : AIDSLINE MED/20328697
- HIV and STD prevention update: perception of risk varies dramatically.
- AIDS Patient Care STDS. 1999 Jul;13(7):445-7. Unique Identifier : AIDSLINE MED/20328698
- Makulowich GS
- Studies on the pathology, especially brain hemorrhage and angioendotheliomas, induced by two new mos-containing viruses.
- J Neurovirol. 2000 Apr;6(2):106-20. Unique Identifier : AIDSLINE MED/20284032
- Lim KY; Ryan EA; Wong PK; Yuen PH; Department of Carcinogenesis, Science Park-Research Division, The; University of Texas M.D. Anderson Cancer Center, Smithville,; Texas, TX 78957, USA.
- Recombinant virus 7 (R7), a spontaneous deletion mutant of SV7, which is itself a molecular clone of Moloney murine sarcoma virus 124 (MoMuSV 124), induces brain lesions and tumors of the subcutaneous tissue and spleen in all infected mice. In contrast, SV7 only induces tumors of the spleen and subcutaneous tissues. O
- Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis.
- J Neurovirol. 2000 Apr;6(2):121-6. Unique Identifier : AIDSLINE MED/20284033
- Hara T; Yamashita S; Aiba H; Nihei K; Koide N; Good RA; Takeshita K; Department of Pediatrics, Graduate School of Medical Sciences,; Kyushu University, Fukyoka, Fukuoka, Japan.
- Live measles virus-specific T helper 1/T helper 2-cytokine productions by peripheral blood mononuclear cells in response to live measles, mumps or varicella virus were measured in 15 patients with subacute sclerosing panencephalitis and 15 controls by enzyme-linked immunosorbent assays. Most patients with subacute scl
- Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues.
- J Neurovirol. 2000 Apr;6(2):145-55. Unique Identifier : AIDSLINE MED/20284036
- Hudson L; Liu J; Nath A; Jones M; Raghavan R; Narayan O; Male D; Everall I; Department of Neuropathology, Institute of Psychiatry,; DeCrespigny Park, London SE5 8AF, UK.
- Neuropathologically, human immunodeficiency virus (HIV) is associated with a range of inflammatory disorders, extensive cortical neuronal loss, and dendritic and synaptic damage. Although the mechanisms resulting in these abnormalities are still unclear, the neurotoxic effects are thought to be due in part to viral pr
- Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases.
- EBROSPINAL FLUID/ENZYMOLOGY Tuberculosis, Meningeal/CEREBROSPINAL FLUID/ENZYMOLOGY J Neurovirol. 2000 Apr;6(2):156-63. Unique Identifier : AIDSLINE MED/20284037
- Liuzzi GM; Mastroianni CM; Santacroce MP; Fanelli M; D'Agostino C; Vullo V; Riccio P; Department of Biochemistry and Molecular Biology, University of; Bari, 70126 Bari, Italy.
- PCR detection of host and HIV-1 sequences from archival brain tissue.
- J Neurovirol. 2000 Apr;6(2):164-71. Unique Identifier : AIDSLINE MED/20284038
- Smith KM; Crandall KA; Kneissl ML; Navia BA; Program in Genetics, Tufts University, Sackler School of; Biological and Biomedical Sciences, 136 Harrison Avenue, Boston,; Massachusetts, MA 02111, USA.
- Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associat
- Risk and management of blood-borne infections in health care workers.
- Clin Microbiol Rev. 2000 Jul;13(3):385-407. Unique Identifier : AIDSLINE MED/20344705
- Beltrami EM; Williams IT; Shapiro CN; Chamberland ME; HIV Infections Branch, Hospital Infections Program, National; Center for Infectious Diseases, Centers for Disease Control and; Prevention, Public Health Service, U.S. Department of Health and; Human Services, Atlanta, Georgia 30333, USA. ebj4@cdc.gov
- Exposure to blood-borne pathogens poses a serious risk to health care workers (HCWs). We review the risk and management of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in HCWs and also discuss current methods for preventing exposures and recommendations for postex
- Epidemiological features of drug resistant tuberculosis in Harare, 1994 to 1996.
- Cent Afr J Med. 1999 Nov;45(11):282-7. Unique Identifier : AIDSLINE MED/20350373
- Makombe RR; Easterbrook PJ; Lowe O; Ferguson AD; Neill P; Ndudzo A; van der Have JJ; Mbengeranwa OL; Beatrice Road Infectious Diseases Hospital, City Health; Department, Harare, Zimbabwe.
- OBJECTIVES: To characterise the prevalence, clinical and radiological features of drug resistant tuberculosis in selected patients with pulmonary tuberculosis in Harare between 1994 and 1996. DESIGN: A retrospective review of medical and microbiological records. SETTING: Beatrice Road Infectious Diseases Hospital, Har
- Serum immunoglobulin levels in paediatric patients with pneumonia.
- Cent Afr J Med. 1999 Nov;45(11):300-2. Unique Identifier : AIDSLINE MED/20350377
- Mazengera LR; Nathoo KJ; Zegers BJ; Department of Immunology, University of Zimbabwe Medical School,; Avondale, Harare, Zimbabwe.
- OBJECTIVE: To determine levels of serum immunoglobulins IgG, IgM and IgA in patients admitted with pneumonia to Harare Central Hospital paediatric wards. DESIGN: A cross sectional pilot study. SETTING: Harare Central Hospital, Department of Immunology, University of Zimbabwe ; Dep
- Alcohol consumption in HIV-I infected persons: a study of immunological markers, Harare, Zimbabwe.
- Cent Afr J Med. 1999 Nov;45(11):303-8. Unique Identifier : AIDSLINE MED/20350378
- Chandiwana SK; Sebit MB; Latif AS; Gomo E; Acuda SW; Makoni F; Vushe J; Blair Research Institute, Harare.
- OBJECTIVE: To examine the effect of alcohol use in relation to the age, gender and plasma levels of HIV-I RNA and CD4 cells count in HIV-I infected persons as a prognostic indicator for the disease progression to AIDS. DESIGN: A community based cohort study. SETTING: The study was conducted at the Blair Research Insti
- CD8(+) T cells secreting type 2 lymphokines are defective in protection against viral infection.
- Cell Immunol. 2000 May 25;202(1):13-22. Unique Identifier : AIDSLINE MED/20334541
- Wirth S; van den Broek M; Frossard CP; Hugin AW; Leblond I; Pircher H; Hauser C; Allergy Unit, Division of Immunology and Allergy, Hopital; Cantonal Universitaire, Geneva, Switzerland.
- Effector T cells secreting type 1 and/or type 2 lymphokines (Tc1, Tc0, Tc2) were generated in vitro from CD8(+) T cells of mice with a transgenic TCR recognizing lymphocytic choriomeningitis virus (LCMV) glycoprotein to compare their effector function in vitro and in vivo. Tc1, Tc2, and Tc0 showed similar Fas- and per
- Preferential proliferation and differentiation of double-positive thymocytes into CD8(+) single-positive thymocytes in a novel cell culture medium.
- Cell Immunol. 2000 May 25;202(1):41-53. Unique Identifier : AIDSLINE MED/20334544
- Gao JX; Zhang J; Awaraji C; Bhatia M; Jevnikar A; Singh B; Bell D; Delovitch TL; Autoimmunity/Diabetes Group, The University of Western Ontario,; London, Ontario, N6G 2V4, Canada.
- The identification of factors that regulate the proliferation and differentiation of double-positive (DP) into CD4(+) and CD8(+) single-positive (SP) thymocytes has proven difficult due to the inability of DP thymocytes to proliferate, expand, and differentiate into SP thymocytes in available cell culture media. Here
- Role of T cell subsets in the modulation of Mycobacterium avium growth within human monocytes.
- Cell Immunol. 2000 May 25;202(1):6-12. Unique Identifier : AIDSLINE MED/20334540
- Shiratsuchi H; Krukovets I; Ellner JJ; Case Western Reserve University, Cleveland, Ohio, 44106-4984,; USA.
- Mycobacterium avium frequently causes disseminated disease in patients with advanced AIDS with low CD4 counts. The effects of T lymphocyte on intracellular M. avium replication were examined. Plastic adherent monocytes and nonadherent lymphocytes were separated from peripheral blood mononuclear cells. After infection
- gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice.
- Cell Immunol. 2000 May 25;202(1):61-9. Unique Identifier : AIDSLINE MED/20334546
- Naiki Y; Nishimura H; Itohara S; Yoshikai Y; Laboratory of Host Defense and Germ-free Life, Nagoya University; School of Medicine, Nagoya, 466-0053, Japan.
- To investigate the roles of gammadelta T cells in Salmonella infection, we examined the resolution of an intraperitoneal infection with avirulent Salmonella choleraesuis 31N-1 in mice lacking T-cell-receptor (TCR) alphabeta T cells by disruption of the TCRbeta chain gene (TCRbeta(-/-)). The bacteria in TCRbeta(-/-) mi
- Antiretroviral combination therapy in HIV-1 infected women and men: are their responses different?
- Int J Fertil Womens Med. 2000 Mar-Apr;45(2):195-9. Unique Identifier : AIDSLINE MED/20290036
- Zorrilla CD; Department of Obstetrics and Gynecology, University of Puerto; Rico, School of Medicine, San Juan 00936-5067, USA.
- Women are the fastest growing segment of the AIDS cases in the United States . They constitute nearly half of all the AIDS cases worldwide. Recent advances in Highly Active Antiretroviral Therapies (HAART) have reduced AIDS mortality remarkably. But as longer use of these combination re
- C-sections recommended for HIV+ pregnant women.
- AWHONN Lifelines. 1999 Oct-Nov;3(5):17. Unique Identifier : AIDSLINE MED/20286914
- Pain management in HIV-positive patients.
- Adv Nurse Pract. 1999 Nov;7(11):49-51. Unique Identifier : AIDSLINE MED/20346006
- Epley D; Florida State University School of Nursing, Tallahassee, USA.
- Mouse mammary tumor virus-like ENV gene sequences in human breast tumors and in a lymphoma of a breast cancer patient.
- Clin Cancer Res. 2000 Apr;6(4):1273-8. Unique Identifier : AIDSLINE MED/20239222
- Etkind P; Du J; Khan A; Pillitteri J; Wiernik PH; Our Lady of Mercy Medical Center-Comprehensive Cancer Center, New; York Medical College, Bronx 10466-4002, USA.
- DNA sequences with very high similarity (95-98%) to the mouse mammary tumor virus (MMTV) ENV gene have been amplified by PCR in 38.5% of human breast tumors and in
- Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma.
- Clin Cancer Res. 2000 Apr;6(4):1351-64. Unique Identifier : AIDSLINE MED/20239234
- Saito T; Dworacki G; Gooding W; Lotze MT; Whiteside TL; University of Pittsburgh Cancer Institute, University of; Pittsburgh School of Medicine, Pennsylvania 15213, USA.
- Peripheral blood mononuclear cells (PBMCs) obtained from patients with advanced melanoma but not from healthy individuals were found to undergo spontaneous ex vivo apoptosis upon incubation in medium. PBMCs were evaluated for evidence of apoptosis using Annexin V binding, caspase-3 activation, and DNA fragmentation (t
- A new vector-search rotation function: image-seeking functions revisited in macromolecular crystallography.
- Acta Crystallogr D Biol Crystallogr. 2000 Jun;56 ( Pt 6):735-46. Unique Identifier : AIDSLINE MED/20280188
- Borge J; Alvarez-Rua C; Garcia-Granda S; Departamento de Quimica Fisica y Analitica, Facultad de; Quimica, Universidad de Oviedo, Spain.; jjba@sauron.quimica.uniovi.es
- A new rotation function in Patterson space is described. An image-seeking function can be defined as a criterion of fit between the observed Patterson map and a suitable vector set extracted from a specially calculated Patterson map of the search model. The behaviour of image-seeking functions has appeared to be heavi
- Unique morphological alterations of the HTLV-I transformed C8166 cells by infection with HIV-1.
- Pathol Oncol Res. 2000;6(1):27-37. Unique Identifier : AIDSLINE MED/20213656
- Ongradi J; Laird HM; Szilagyi JF; Horvath A; Bendinelli M; National Institute of Dermato-Venerology Maria utca 41.,; Budapest, 1085, Hungary. ongjos@hotmail.com
- C8166 cells express T lymphocyte markers, a monocyte-specific esterase, taxpolypeptide of HTLV-I. In spite of this transactivator, their HIV-1 yield is low. Their culture conditions were modified, and infected cells were immobilized on a poly-L-lysine sheet under semisolid overlays to study their phenotypic alteration
- International conference spotlights disaster in sub-Saharan Africa [news]
- Circulation. 2000 Jul 18;102(3):E9005-6. Unique Identifier : AIDSLINE MED/20359943
- SoRelle R
- NMR structure of an anti-gp120 antibody complex with a V3 peptide reveals a surface important for co-receptor binding.
- Structure Fold Des. 2000 Apr 15;8(4):385-95. Unique Identifier : AIDSLINE PDB/1NQZ
- Tugarinov V; Zvi A; Levy R; Hayek Y; Matsushita S; Anglister J; Department of Structural Biology, The Weizmann Institute of; Science, Rehovot, 76100, Israel.
- BACKGROUND: The protein 0.5beta is a potent strain-specific human immunodeficiency virus type 1 (HIV-1) neutralizing antibody raised against the entire envelope glycoprotein (gp120) of the HIV-1(IIIB) strain. The epitope recognized by 0.5beta is located within the third hypervariable region (V3) of gp120. Recently, se
- New developments in the treatment of HIV disease: an overview.
- J Child Fam Nurs. 1999 Nov-Dec;2(6):439-41. Unique Identifier : AIDSLINE MED/20306393
- Kiernan BS
- Most env and gag subtype A HIV-1 viruses circulating in West and West Central Africa are similar to the prototype AG recombinant virus IBNG.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):363-74. Unique Identifier : AIDSLINE +
- Montavon C; Toure-Kane C; Liegeois F; Mpoudi E; Bourgeois A; Vergne L; Perret JL; Boumah A; Saman E; Mboup S; Delaporte E; Peeters M; Laboratoire Retrovirus, Institut pour la Recherche en; Developement, Montpellier, France.
- The genetic subtype was identified in gag and env of 219 HIV-1-positive samples collected in different African countries, 44 from Senegal , 55 from Cameroon , 82 from Gabon , and 38 from
- Fluctuations in HIV-1 viral load are correlated to CD4+ T-lymphocyte count during the natural course of infection.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):375-9. Unique Identifier : AIDSLINE MED/20322598
- Masel J; Arnaout RA; O'Brien TR; Goedert JJ; Lloyd AL; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Department of Zoology, University of Oxford, UK.
- Viral load fluctuates during the natural course of asymptomatic HIV-1 infection. It is often assumed that these fluctuations are random around a set point or underlying growth trend. Using longitudinal data, we tested whether fluctuations in viral load can be better explained by changes in CD4+ T-cell count than by a
- HAART is neuroprophylactic in HIV-1 infection.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):380-5. Unique Identifier : AIDSLINE MED/20322599
- von Giesen HJ; Hefter H; Jablonowski H; Arendt G; Department of Neurology, Heinrich Heine University, Dusseldorf,; Germany. giesenhj@uni-duesseldorf.de
- BACKGROUND: To find out about the prophylactic value of antiretroviral therapy on HIV-1-associated subclinical and clinical psychomotor slowing as one marker of HIV-1-associated CNS disease. METHODS: Prospective study with regular clinical and neurophysiologic examination every three months of 1482 consecutive HIV-1-s
- Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):386-95. Unique Identifier : AIDSLINE MED/20322600
- Gifford AL; Bormann JE; Shively MJ; Wright BC; Richman DD; Bozzette SA; Health Services Research and Development, VA San Diego Healthcare; System, California 92161, USA. agifford@ucsd.edu
- BACKGROUND: Adherence to prescribed medications is a central feature of good clinical HIV care, but little is known about the factors associated with multidrug antiretroviral adherence, or about how such adherence is related to plasma HIV suppression. METHODS: We collected data from 133 HIV-infected adults receiving a
- Impact of medical and nonmedical factors on physician decision making for HIV/AIDS antiretroviral treatment.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):396-404. Unique Identifier : AIDSLINE MED/20322601
- Bogart LM; Kelly JA; Catz SL; Sosman JM; Department of Psychology, Kent State University, Ohio 44242-0001,; USA. lbogart@kent.edu
- To examine influences of medical factors (e.g., viral load) and nonmedical factors (e.g., patient characteristics) on treatment decisions for highly active antiretroviral therapy (HAART), we sent a survey to a random sample of 995 infectious disease physicians who treat patients with HIV/AIDS in the
- High HIV incidence and prevalence among young women in rural South Africa: developing a cohort for intervention trials.
- Unique Identifier : AIDSLINE MED/20322602
- Wilkinson D; Abdool Karim SS; Williams B; Gouws E
- OBJECTIVE: To measure prevalence and model incidence of HIV infection. SETTING: 2013 consecutive pregnant women attending public sector antenatal clinics in 1997 in Hlabisa health district, South Africa . Historical seroprevalence data, 1992-1995. METHODS: Serum remaining from syph
- Monitoring of HIV-1 infection prevalence and trends in the general population using pregnant women as a sentinel population: 9 years experience from the Kagera region of Tanzania.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):410-7. Unique Identifier : AIDSLINE MED/20322603
- Kwesigabo G; Killewo JZ; Urassa W; Mbena E; Mhalu F; Lugalla JL; Godoy C; Biberfeld G; Emmelin M; Wall S; Sandstrom A; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; gkwesigabo@muchs.ac.tz
- In the Kagera region of Tanzania , a population-based study was initiated in 1987 followed by the establishment of antenatal-clinic-based sentinel surveillance system in the town of Bukoba in 1990. Repeat studies in both populations in Bukoba in 1993 and 1996 made it possible to s
- Case-control study of risk factors for incident HIV infection in rural Uganda.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):418-25. Unique Identifier : AIDSLINE MED/20322604
- Quigley MA; Morgan D; Malamba SS; Mayanja B; Okongo MJ; Carpenter LM; Whitworth JA; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
- OBJECTIVE: To identify risk factors associated with HIV incidence in a rural Ugandan population. DESIGN: Case-control study. METHODS: Men and women who seroconverted between 1990 and 1997 (cases) and seronegative subjects (controls) were drawn from a general population cohort of approximately 5000 adults in rural, sou
- Low estimates of HIV seroconversions among clients of a drug treatment clinic in San Francisco, 1995 to 1998.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):426-9. Unique Identifier : AIDSLINE MED/20322605
- McFarland W; Kellogg TA; Louie B; Murrill C; Katz MH; Department of Public Health, San Francisco, California; 94102-6033, USA. WilliMcFarland@dph.sf.ca.us
- We estimated HIV incidence among injection drug users attending a drug treatment clinic in San Francisco from 1995 to 1998 using two methods. An anonymous sequential testing method identified no seroconversions among clients seen more than once during the period (one-sided upper 95% confidence limit 1.02 per 100 perso
- Distribution of HIV-1 subtypes among HIV-seropositive patients in the interior of Cote d'Ivoire.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):430-6. Unique Identifier : AIDSLINE GENBANK/AF216889
- Nkengasong JN; Luo CC; Abouya L; Pieniazek D; Maurice C; Sassan-Morokro M; Ellenberger D; Hu DJ; Pau CP; Dobbs T; Respess R; Coulibaly D; Coulibaly IM; Wiktor SZ; Greenberg AE; Rayfield M; Laboratory of Virology, Project RETRO-CI, Abidjan, Cote; d'Ivoire. jcn5@cdc.gov
- Limited data exist on the distribution of HIV-1 subtypes in Cote d Ivoire . The aim of this study is to describe the distribution of genetic subtypes of HIV-1 strains in six regions of Cote d Ivoire. In 1997, we consecutively collected blood from 172 HIV-1-infected patients fro
- Multigenic polymorphisms of HIV-1 coreceptors and vertical transmission [letter; comment]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):437. Unique Identifier : AIDSLINE MED/20322607
- Araujo F; Miranda M; Koch C; Marques R; Cunha-Ribeiro LM
- Routine ophthalmologic screening for cytomegalovirus retinitis in patients with AIDS [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):438-9. Unique Identifier : AIDSLINE MED/20322608
- Wohl DA; Pedersen S; van der Horst CM
- Effects of 2-year antiretroviral combination therapies on HIV-1 DNA levels [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):439-41. Unique Identifier : AIDSLINE MED/20322609
- Zanussi S; Bortolin MT; Tirelli U; Nasti G; Vaccher E; Giacca M; De Paoli P
- No evidence of HTLV-I or HTLV-II infection among the Hmong people of northern Thailand or injecting drug users in Bangkok [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):441-2. Unique Identifier : AIDSLINE MED/20322610
- Louisiriotchanakul S; Thongput A; Khamboonruang C; Taylor GP; Kunstadter P; Wasi C
- Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):1-9. Unique Identifier : AIDSLINE MED/20334000
- Tscherning-Casper C; Vodros D; Menu E; Aperia K; Fredriksson R; Dolcini G; Chaouat G; Barre-Sinoussi F; Albert J; Fenyo EM; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden. charlotte.tscherning@mtc.ki.se
- In this study, coreceptor usage of HIV-1 other than subtype B in relation to HIV-1 transmission from mother to child was investigated. Repeated sampling of 42 HIV-1-seropositive, asymptomatic women in Cameroon during the second and third trimesters of pregnancy, at delivery, and
- A novel role for tumor necrosis factor-alpha in regulating susceptibility of activated CD4+ T cells from human and nonhuman primates for distinct coreceptor using lentiviruses.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):10-22. Unique Identifier : AIDSLINE MED/20334001
- Brice GT; Mayne AE; Villinger F; Ansari AA; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.
- Although CD4+ T-cell activation has long been shown to promote infection and replication of simian immunodeficiency virus (SIV) and HIV, recent studies have documented that not all activated CD4+ T cells from human and nonhuman primates are susceptible to infection with HIV/SIV, respectively. Activation of CD4+ T cell
- Autopsy study of HIV-1-positive and HIV-1-negative adult medical patients in Nairobi, Kenya.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):23-9. Unique Identifier : AIDSLINE MED/20334002
- Rana FS; Hawken MP; Mwachari C; Bhatt SM; Abdullah F; Ng'ang'a LW; Power C; Githui WA; Porter JD; Lucas SB; Department of Pathology, University of Nairobi and Kenyatta; National Hospital, Nairobi, Kenya.
- HIV infection has now been consistently identified as the major cause of death in young Africans in both urban and rural areas. In Africa, several studies have defined the clinical presentation of HIV disease but there have only been a limited number of autopsy studies. Because of the scarcity of autopsy data and the
- Clinical prediction model for differentiation of disseminated Histoplasma capsulatum and Mycobacterium avium complex infections in febrile patients with AIDS.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):30-6. Unique Identifier : AIDSLINE MED/20334003
- Graviss EA; Vanden Heuvel EA; Lacke CE; Spindel SA; White AC Jr; Hamill RJ; Section of Infectious Diseases, Veterans Affairs Medical Center,; Houston, Texas 77030-4211, USA.
- BACKGROUND: Disseminated infection with Histoplasma capsulatum and Mycobacterium avium complex (MAC) in patients with AIDS are frequently difficult to distinguish clinically. METHODS: We retrospectively compared demographic information, other opportunistic infections, medications, symptoms, physical examination findin
- Randomized controlled trial assessing the effect of vitamin A supplementation on maternal morbidity during pregnancy and postpartum among HIV-infected women.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):37-44. Unique Identifier : AIDSLINE MED/20334004
- Kennedy CM; Coutsoudis A; Kuhn L; Pillay K; Mburu A; Stein Z; Coovadia H; Joseph L. Mailman School of Public Health, Columbia University,; New York City, New York 10032, USA.
- OBJECTIVE: To determine whether low-cost treatment of HIV using vitamin A would be beneficial, we examined the effect of vitamin A supplementation on morbidity of HIV-1 infected women. METHODS: We conducted a randomized, double blind placebo-controlled trial at King Edward VIII Hospital, in Durban,
- Trends in antiretroviral therapy and mother-infant transmission of HIV. The Women and Infants Transmission Study Group.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):45-7. Unique Identifier : AIDSLINE MED/20334005
- Cooper ER; Charurat M; Burns DN; Blattner W; Hoff R; Boston Medical Center, Department of Pediatrics, Boston; University School of Medicine, Massachusetts, USA.
- Trends in the vertical transmission rate of HIV and evolving antiretroviral usage between 1990 and 1998 within the Women and Infants Transmission Study were evaluated. A decline in mother-infant transmission was temporally associated with advances in therapy, especially when regimens including a protease inhibitor wer
- Sexually transmitted diseases and the increased risk for HIV transmission: implications for cost-effectiveness analyses of sexually transmitted disease prevention interventions.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):48-56. Unique Identifier : AIDSLINE MED/20334006
- Chesson HW; Pinkerton SD; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.
- We estimated the annual number and cost of new HIV infections in the United States attributable to other sexually transmitted diseases (STDs). We used a mathematical model of HIV transmission to estimate the probability that a given STD infection would facilitate HIV transmission from
- Comparing new participants of a mobile versus a pharmacy-based needle exchange program.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):57-61. Unique Identifier : AIDSLINE MED/20334007
- Riley ED; Safaeian M; Strathdee SA; Marx MA; Huettner S; Beilenson P; Vlahov D; Department of Epidemiology, The Johns Hopkins School of Hygiene; and Public Health, Baltimore, Maryland, USA.
- OBJECTIVE: To compare characteristics of first-time needle exchange participants who enrolled at a mobile van-based exchange site versus a fixed pharmacy-based exchange site, in an area where both types of needle exchange programs were available. METHODS: Demographic and drug use data were collected on needle exchange
- Effect of intravaginal practices on the vaginal and cervical mucosa of Zimbabwean women.
- Unique Identifier : AIDSLINE MED/20334008
- van de Wijgert JH; Chirenje ZM; Iliff V; Mbizvo MT; Mason PR; Gwanzura L; Shiboski S; Padian NS
- OBJECTIVES: Lesions on the vaginal and cervical mucosa may facilitate transmission of HIV and other sexually transmitted diseases (STDs). We evaluated the relationship between intravaginal practices and the presence of colposcopic lesions in Zimbabwean women. METHODS: Users and nonusers of intravaginal practices were
- Effect of HIV infection on menstrual cycle length.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):68-75. Unique Identifier : AIDSLINE MED/20334009
- Harlow SD; Schuman P; Cohen M; Ohmit SE; Cu-Uvin S; Lin X; Anastos K; Burns D; Greenblatt R; Minkoff H; Muderspach L; Rompalo A; Warren D; Young MA; Klein RS; University of Michigan, Ann Arbor, USA.
- HIV serostatus and menstrual function were examined using prospectively collected menstrual data from 802 HIV-seropositive and 273 HIV-seronegative women, ages 20 to 44, enrolled in two cohort studies of HIV infection in North American women. The associations between HIV serostatus and the probabilities of having a cy
- Can early failure with nevirapine be rescued with efavirenz? [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):76-8. Unique Identifier : AIDSLINE MED/20334010
- Briones C; Soriano V; Dona C; Barreiro P; Gonzalez-Lahoz J
- Reversal of hyperlipidemia and lipodystrophy in patients switching therapy to nelfinavir [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):78-9. Unique Identifier : AIDSLINE MED/20334011
- Duncombe C
- Eradication of Helicobacter pylori is associated with increased exposure to delavirdine in hypochlorhydric HIV-positive patients [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):79-82. Unique Identifier : AIDSLINE MED/20334012
- Shelton MJ; Akbari B; Hewitt RG; Adams JM; Morse GD
- Definition of virologic response and the type of assay used for quantification of viral load may influence the proportion of responders to antiretroviral therapy. APROCO Study Group [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):82-3. Unique Identifier : AIDSLINE MED/20334013
- Le Moing V; Chene G; Masquelier B; Sicard D; Brun-Vezinet F; Reynes J; Raffi F
- High, low, and very low viral loads of HIV in the United States [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):83-4. Unique Identifier : AIDSLINE MED/20334014
- Peter JB
- Antiretroviral combination therapies and AIDS-defining cancers [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):84-6. Unique Identifier : AIDSLINE MED/20334015
- Serraino D; Pezzotti P; Boros S; Rezza G
- Lack of evidence for a role of HTLV-I infection in the occurrence of subclinical HAM/TSP in the Miyazaki Cohort Study [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):86-7. Unique Identifier : AIDSLINE MED/20334016
- Abtahi A; Mueller N; Okayama A; Stuver S
- Seroprevalence of parvovirus B19 among HIV-1-positives in Japan.
- Jpn J Infect Dis. 2000 Feb;53(1):21. Unique Identifier : AIDSLINE MED/20242107
- Taguchi H; Yamada T; Takahashi T; Gotoh M; Nakamura T; Iwamoto A; Department of Infectious Diseases, Institute of Medical Science,; University of Tokyo, Tokyo 108-8639, Japan.
- The "beta-fluorine effect" in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates.
- Unique Identifier : AIDSLINE MED/20232684
- Siddiqui MA
- Conformation and local environment of nucleotides bound to HIV type 1 reverse transcriptase (HIV-1 RT) in the ground state.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):13-29. Unique Identifier : AIDSLINE MED/20232685
- Painter GR; Andrews CW; Furman PA; Triangle Pharmaceuticals, Inc. Durham, NC, USA.
- Nuclear Overhauser effect experiments were used to characterize the protein environment and conformations of dTTP, dATP and AZTTP bound to HIV-RT in the ground state. The results show the initial binding sites for the nucleotides overlap but are not completely coincident. All of the bound nucleotides assume the same a
- Benzimidazole 2'-isonucleosides: design, synthesis, and antiviral activity of 2-substituted-5,6-dichlorobenzimidazole 2'-isonucleosides.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):155-74. Unique Identifier : AIDSLINE MED/20232692
- Freeman GA; Selleseth DW; Rideout JL; Harvey RJ; Division of Medicinal Chemistry, GlaxoWellcome Research, North; Carolina 27709, USA.
- 2,5,6-Trihalogenated benzimidazole-beta-D-ribofuranosyl nucleosides and 2-substituted amino-5,6-dichlorobenzimidazole-beta-L-ribofuranosyl nucleosides are potent and selective inhibitors of human cytomegalovirus (HCMV). The D-ribofuranosyl analogs are metabolized rapidly in vivo re
- Synthesis and antiviral evaluation of unnatural beta-L-enantiomers of 3'-fluoro- and 3'-azido-2',3'-dideoxyguanosine derivatives.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):205-17. Unique Identifier : AIDSLINE MED/20232695
- Marchand A; Mathe C; Imbach JL; Gosselin G; Laboratoire de Chimie Organique Biomoleculaire de Synthese,; U.M.R. CNRS 5625, Universite de Montpellier II, France.
- 3 -fluoro-2 ,3 -dideoxy- (3) and 3 -azido-2 ,3 -dideoxy- (4) beta-L-ribofuranonucleoside derivatives of guanine have been synthesized and their antiviral properties examined. All these derivatives were regioselectively and stereospecifically prepared by glycosylation of 2-N-acetyl-6-O-(diphenylcarbamoyl)guanine 5 with
- Synthesis of L-3'-hydroxymethylribonucleosides.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):219-36. Unique Identifier : AIDSLINE MED/20232696
- Cooperwood JS; Boyd V; Gumina G; Chu CK; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens 30602-2352, USA.
- The target compounds were synthesized via the key intermediate carbohydrate 8, which was synthesized by first selectively protecting the 1 - and 2 -hydroxyl groups followed by selective tosylation of the 5 -hydroxyl group to obtain compound 3. The tosyl moiety was then replaced by a benzyl either to obtain 4. Compound
- Synthesis and antiviral activities of enantiomeric 1-[2-(hydroxymethyl) cyclopropyl] methyl nucleosides.
- Unique Identifier : AIDSLINE MED/20232698
- Pierra C; Olgen S; Cavalcanti SC
- Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):283-95. Unique Identifier : AIDSLINE MED/20232701
- Nishizono N; Nair V; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.
- The aminoglycosidic antibiotic, neomycin B, is an inhibitor of the binding of Rev to RRE. This paper reports on the synthesis of analogs of neomycin B as potential anti-HIV compounds designed to function as inhibitors of Rev/RRE binding.
- An efficient, scalable synthesis of the HIV reverse transcriptase inhibitor Ziagen (1592U89).
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):297-327. Unique Identifier : AIDSLINE MED/20232702
- Daluge SM; Martin MT; Sickles BR; Livingston DA; Division of Medicinal Chemistry, Glaxo Wellcome Inc., Research; Triangle Park, North Carolina 27709, USA.
- Ziagen , (1S,cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]- 2-cyclopentene-1-methanol, was synthesized from (1S,4R)-azabicyclo[2.2.1]hept-5-en-3-one by efficient processes which bypass problematic steps in earlier routes. 2-Amino-4,6-dichloro-5-f
- Synthesis of (Z)- and (E)-9-[(2-hydroxyethylidene)cyclopropyl]adenine--new methylenecyclopropane analogues of adenosine and their substrate activity for adenosine deaminase.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):31-7. Unique Identifier : AIDSLINE MED/20232686
- Qui YL; Ksebati MB; Zemlicka J; Department of Chemistry, Barbara Ann Karmanos Cancer Institute,; Wayne State University School of Medicine, Detroit, MI; 48201-1379, USA.
- Synthesis of Z- and E-methylenecyclopropane analogues of adenosine 3 and 4 by alkylation of adenine with novel alkylating agent 5 is described. The E-isomer 4 is a substrate for adenosine deaminase. Compounds 3 and 4 were tested for antiviral activity against HCMV, HSV-1, HSV-2, EBV, VZV, HBV and HIV-1.
- Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):371-7. Unique Identifier : AIDSLINE MED/20232706
- Gao WY; Johns DG; Mitsuya H; Experimental Retrovirology Section, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-4255,; USA.
- Low levels of the CTP synthase inhibitor 3-deazauridine (3-DU) strongly potentiated the anti-HIV-1 activity of the 5 -triphosphates of the cytidine-based analogues [-]2 -deoxy-3 -thiacytidine ( 3TC ; lamivudine) and 2 ,3 -dideoxycytidine (
- Cellular phosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key intermediate in the activation of the antiviral agent DDI, in human peripheral blood mononuclear cells.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):405-13. Unique Identifier : AIDSLINE MED/20232708
- Robbins BL; Greenhaw J; Fridland A; Department of Infectious Disease, St. Jude Children's Research; Hospital, Memphis, TN 38105, USA. brian.robbins@stjude.org
- 2 ,3 -dideoxyadenosine 5-monophosphate (ddAMP), is a key intermediate in the metabolism of the antiviral agent 2 ,3 -dideoxyinosine (ddI) to its active triphosphate derivative, 2 ,3 -dideoxyadenosine-5 -triphosphate (ddATP). The potential role of adenylate kinase in the phosphorylation of ddAMP was studied in human pe
- Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):415-34. Unique Identifier : AIDSLINE MED/20232709
- Graham KA; Leithoff J; Coe IR; Mowles D; Mackey JR; Young JD; Cass CE; Department of Oncology, University of Alberta, Cross Cancer; Institute, Edmonton, Canada.
- The transportability of cytosine-containing nucleosides by recombinant hCNT1 was investigated in transfected mammalian cells. Apparent K(m) values for hCNT1-mediated transport of uridine, cytidine and deoxycytidine were, respectively, 59, 140 and 150 microM. Uridine transport was inhibited 89, 32 and 11%, respectively
- Synthesis and antiviral activity of amino acid carbamate derivatives of AZT.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):87-100. Unique Identifier : AIDSLINE MED/20232689
- Chang SL; Griesgraber G; Abraham TW; Garg T; Song H; Zimmerman CL; Wagner CR; Department of Medicinal Chemistry, College of Pharmacy,; University of Minnesota, Minneapolis 55455, USA.
- Lipophilic amino acid methyl ester and methyl amide carbamates of 3 -azido-3 -deoxythymidine ( AZT ) were synthesized and their anti-HIV-1 activity in PBMCs was determined. The methyl amides were more potent (EC50s = 1.8-4.0 microM) than the methyl este
- Stress and coping: the psychoneuroimmunology of HIV/AIDS.
- Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):615-33. Unique Identifier : AIDSLINE MED/20361000
- Balbin EG; Ironson GH; Solomon GF; University of Miami, Behavioral Medicine Program, Coral Gables,; FL 33124-2070, USA.
- A considerable body of evidence, reviewed in this chapter, suggests that psychosocial factors play an important role in progression of HIV infection, its morbidity and mortality. Psychosocial influences relating to faster disease progression include life-event stress, sustained depression, denial/avoidance coping, con
- Immunoregulation by aqueous humor.
- Cornea. 2000 May;19(3 Suppl):S24-5. Unique Identifier : AIDSLINE MED/20290315
- Mochizuki M; Sugita S; Ishikawa N; Watanabe T; Department of Visual Science, Tokyo Medical and Dental University; Graduate School, Japan.
- PURPOSE: The eye is a classic example of an immune-privileged site. To investigate the local defense system of the eye, the immunosuppressive effects of the aqueous humor on cytokine production was examined. METHODS: Using T cell clones (TCCs) established from infiltrating cells in the aqueous humor of patients with h
- Transverse leukonychia with systemic infection.
- Cutis. 2000 May;65(5):318-20. Unique Identifier : AIDSLINE MED/20285845
- Mautner GH; Lu I; Ort RJ; Grossman ME; New York-Presbyterian Hospital, Columbia-Presbyterian Center,; Dermatology Consultation Service, New York, USA.
- Transverse white nail bands (leukonychia) have been described in association with systemic illnesses and exposure to toxins, and medications. We describe the occurrence of transverse nail bands in two patients following acute systemic illnesses. In the first case, transverse white nail bands developed in a 30-year-old
- Ulcerated atrophic striae from etretinate.
- Cutis. 2000 May;65(5):327-8. Unique Identifier : AIDSLINE MED/20285847
- Bowman PH; Hogan DJ; Louisiana State University Medical Center, Section of Dermatology; Shreveport 71130-3932, USA.
- Oral retinoids such as etretinate and acitretin are commonly associated with dose-dependent, mucocutaneous side effects such as dryness, peeling, and fragility. Although these effects can be extreme in some patients and even require discontinuation of treatment, thinning of skin to the point of atrophy and ulceration
- Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
- Drug Metab Dispos. 2000 Jun;28(6):655-60. Unique Identifier : AIDSLINE MED/20281460
- Choo EF; Leake B; Wandel C; Imamura H; Wood AJ; Wilkinson GR; Kim RB; Departments of Medicine and Pharmacology, Division of Clinical; Pharmacology, Vanderbilt University School of Medicine,; Nashville, Tennessee, USA.
- HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and testes (sanctuary sites) are possibly protected from exposure to HIV protease inhibitors due to drug entry being limited by the membrane
- First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism.
- Drug Metab Dispos. 2000 Jun;28(6):672-9. Unique Identifier : AIDSLINE MED/20281463
- Zimmerman CL; Wen Y; Remmel RP; Departments of Pharmaceutics and Medicinal Chemistry, University; of Minnesota, College of Pharmacy, Minneapolis, Minnesota, USA.; zimme005@tc.umn.edu
- A CBV [(-)-carbovir, (-)-carbocyclic 2 ,3 -didehydro-2 , 3 -dideoxyguanosine] prodrug, 6AC [(-)-6-aminocarbovir, (-)-carbocyclic 2 ,3 -didehydro-2 , 3 -dideoxy-6-deoxy-6-aminoguanosine], was previously evaluated in rats, and it exhibited superiority to the parent drug in increasing systemic and central nervous system
- [Metabolic complications of antiretroviral therapy of HIV infection]
- Dtsch Med Wochenschr. 2000 Jun 16;125(24):771-3. Unique Identifier : AIDSLINE MED/20360974
- Goebel FD; Walli R; Medizinische Poliklinik, Klinikum Innenstadt, Munchen.
- Dominant expansion of human T cells in non-obese diabetic/severe combined immunodeficiency mice implanted with human bone fragments.
- Exp Hematol. 2000 Jul;28(7):792-801. Unique Identifier : AIDSLINE MED/20362887
- Fujiki Y; Onodera M; Yamaguchi T; Osawa M; Sudo K; Hamada H; Ema H; Shibuya A; Takiguchi M; Kubo T; Nakauchi H; Department of Immunology, Institute of Basic Medical Sciences and; Center for Tsukuba Advanced Research Alliance, University of; Tsukuba and CREST, Japan Science and Technology Corporation,; Ibaraki.
- OBJECTIVE: To establish an in vivo animal model in which human T cells develop and function normally, a step toward developing new vaccines or chemical compounds that modulate immune functions and toward understanding T-cell immunity in humans. MATERIALS AND METHODS: Human bone fragments were implanted into non-obese
- Regulatory role of Th-2 cytokines, IL-10 and IL-4, in cardiac allograft rejection.
- Exp Mol Pathol. 2000 Aug;69(1):1-9. Unique Identifier : AIDSLINE MED/20351361
- Mulligan MS; Warner RL; McDuffie JE; Bolling SF; Sarma JV; Ward PA; Division of Cardiothoracic Surgery, University of Washington; Medical Center, Seattle, Washington, 98195, USA.
- The host response to alloantigen results in T- and B-cell activation, upregulation of Class II MHC antigens, and cytokine production by Th-1 cells, resulting in generation of IL-2 and IFN gamma. Th-2 cell responses produce IL-4 and IL-10 which may shift the immune resp
- Chemokine receptor-related genetic sequences in an african green monkey simian cytomegalovirus-derived stealth virus.
- Exp Mol Pathol. 2000 Aug;69(1):10-6. Unique Identifier : AIDSLINE MED/20351362
- Martin WJ; Center for Complex Infectious Diseases, Rosemead, California,; 91770, USA.
- The US28 gene of human cytomegalovirus (HCMV) codes a cell surface receptor for both beta chemokine and fractalkine molecules. This receptor facilitates HCMV-induced cell fusion and virus dissemination and influences susceptibility to infection with other viruses, including the hum
- Immunohistochemical versus molecular detection of RAK antigens in breast cancer.
- Exp Mol Pathol. 2000 Aug;69(1):27-36. Unique Identifier : AIDSLINE MED/20351364
- Kyriacou KC; Iacovou F; Adamou A; Hadjisavvas A; Rakowicz-Szulczynska EM; The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
- RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by HIV-1 and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men. Binding of the monoclonal antibody (MAb) RAK-BrI to cancer RAK antigens has been found to be inhib
- Human immunodeficiency virus-associated malignant lymphoma in eastern Denmark diagnosed from 1990-1996: clinical features, histopathology, and association with Epstein-Barr virus and human herpesvirus-8.
- Eur J Haematol. 2000 Jun;64(6):368-75. Unique Identifier : AIDSLINE MED/20356768
- Hansen PB; Penkowa M; Kirk O; Skinhoj P; Pedersen C; Lisse I; Kiss K; Zhou X; Hamilton-Dutoit SJ; Department of Infectious Diseases, University of Copenhagen,; Rigshospitalet, Denmark.
- The clinicopathological features of human immunodeficiency virus (HIV)-associated lymphoma were investigated in a retrospective study of 85 adult patients in eastern Denmark diagnosed during the period 1990-1996. The possible pathog
- [Duodenal Burkitt lymphoma in an HIV-negative patient: a medical emergency (letter)]
- Gastroenterol Clin Biol. 2000 Apr;24(4):470-1. Unique Identifier : AIDSLINE MED/20304716
- Foa C; Magne N; Francois E; Peroux JL; Pivot X; Thyss A
- Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group [see comments]
- Gastroenterology. 2000 Jul;119(1):172-80. Unique Identifier : AIDSLINE MED/20349425
- Liaw YF; Leung NW; Chang TT; Guan R; Tai DI; Ng KY; Chien RN; Dent J; Roman L; Edmundson S; Lai CL; Liver Research Unit, Chang Gung Memorial Hospital and University,; Taipei, Taiwan. liveryfl@tp.silkera.net
- BACKGROUND & AIMS: One-year lamivudine therapy significantly suppressed hepatitis B virus (HBV) replication, improved hepatic necroinflammatory activity, and prevented progression of fibrosis. However, the effects of prolonged therapy are unknown. METHODS: A total of 334 Asian patients with chronic hepatitis B from
- Lamivudine therapy for chronic hepatitis B: is longer duration of treatment better? [editorial; comment]
- Gastroenterology. 2000 Jul;119(1):263-6. Unique Identifier : AIDSLINE MED/20349439
- Lok AS
- Breath alkanes as a marker of oxidative stress in different clinical conditions.
- Free Radic Biol Med. 2000 Mar 15;28(6):880-6. Unique Identifier : AIDSLINE MED/20263790
- Aghdassi E; Allard JP; Department of Medicine, The Toronto Hospital, General Division,; Toronto, Canada.
- We assessed oxidative stress in three different clinical conditions: smoking, human immunodeficiency virus (HIV) infection, and inflammatory bowel disease, using breath alkane output and other lipid peroxidation parameters such as plasma lipid peroxides (LPO) and malondialdehyde (MDA). Antioxidant micronutrients such
- [Prophylaxis after occupational exposure to HIV]
- Harefuah. 2000 Apr 16;138(8):671-7. Unique Identifier : AIDSLINE MED/20339425
- Torten D; Bentwich Z
- The cost-effectiveness of prophylaxis for Mycobacterium avium complex in AIDS.
- Int J Technol Assess Health Care. 1999 Summer;15(3):531-47. Unique Identifier : AIDSLINE MED/20332554
- Scharfstein JA; Paltiel AD; Weinstein MC; Seage GR; Losina E; Craven DE; Freedberg KA; Johns Hopkins School of Public Health, USA.
- OBJECTIVE: To develop a simulation model to project costs, life expectancy, and cost-effectiveness in discounted dollars per quality-adjusted life-year (QALY) saved for clinical strategies to prevent Mycobacterium avium complex (MAC) in patients with AIDS. METHODS: We used natural history data from the Multicenter AID
- Health care participation of perinatal women with HIV: what helps and what gets in the way?
- Health Care Women Int. 1999 Nov-Dec;20(6):563-78. Unique Identifier : AIDSLINE MED/20348076
- Bunting SM; Seaton R; Medical College of Georgia School of Nursing, Department of; Community Nursing, Augusta 30912-4250, USA. sbunting@mail.mcg.edu
- Dealing with the reality of the human immunodeficiency virus (HIV) is a life-changing challenge to perinatal women as they try to care for themselves and their children in environments that often include stigma, uncertainty, and limited access to information and health care. Our purpose for this interpretive hermeneut
- Perceived HIV-related sexual risks and prevention practices of African American women in the southeastern United States.
- Health Care Women Int. 1999 Nov-Dec;20(6):579-91. Unique Identifier : AIDSLINE MED/20348077
- Timmons SM; Sowell RL; College of Nursing, University of South Carolina, Columbia, USA.; stimmons1@aol.com
- African American women in the southeastern United States constitute the fastest growing segment of those infected with the human immunodeficiency virus (HIV). Little data exist about the relationships between HIV infection risks and preventive practices. In this article, we describe a
- Preventing perinatal HIV: prenatal HIV testing and strategies to reduce the risk of maternal--fetal HIV transmission.
- J Ark Med Soc. 2000 Jun;97(1):27-8. Unique Identifier : AIDSLINE MED/20345952
- Saccente M; Division of AIDS/STD, Arkansas Department of Health, USA.
- AIDS, anemia, and an abnormal platelet count.
- Hosp Pract (Off Ed). 1999 Sep 15;34(10):39-40. Unique Identifier : AIDSLINE MED/20360204
- Fisher LR; Shah RP; Adelman HM; University of South Florida, USA.
- Validation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance.
- J Chromatogr Sci. 2000 Jun;38(6):246-54. Unique Identifier : AIDSLINE MED/20346802
- Li QC; Tougas T; Cohen K; Lee R; Meagan P; Corson M; Muchnick T; Analytical Sciences Department, Research and Development Center,; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877,; USA.
- Nevirapine ( Viramune ), a dipyridiodiazepinone, is a potent and highly specific nonnucleoside inhibitor of HIV-1 reverse transcriptase. This paper describes the validation of a specific, sensitive, and stability-indicating high-performance liquid chrom
- Immunoflow cytometry and cell block immunohistochemistry in the FNA diagnosis of lymphoma: a review of 73 consecutive cases.
- J Clin Pathol. 2000 Jun;53(6):451-7. Unique Identifier : AIDSLINE MED/20369456
- Mayall F; Dray M; Stanley D; Harrison B; Allen R; Department of Pathology, Waikato Hospital, Hamilton, New Zealand.; mayallf@hwl.co.nz
- AIMS: To review the results of 73 consecutive fine needle aspirations (FNAs) that were collected by a pathologist and analysed by immunoflow cytometry. Material for a cell block was also collected from some of these lesions. METHODS: The setting was a large general hospital in rural
- Immunomodulatory therapy in the management of viral infections in patients with HIV infection.
- Unique Identifier : AIDSLINE MED/20318631
- Conant MA; University of California Medical Center, San Francisco, CA, USA.
- Human immunodeficiency virus (HIV) causes disease by infecting lymphocytes and progressively destroying critical regulatory and effector cells of the immune system, leaving patients vulnerable to a number of bacterial, fungal, and viral infections. Facial herpes (herpes simplex virus-1 [HSV-1]),
- Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4.
- J Immunol. 2000 Jul 1;165(1):10-4. Unique Identifier : AIDSLINE MED/20318692
- Zhang S; Lukacs NW; Lawless VA; Kunkel SL; Kaplan MH; Department of Microbiology and Immunology, Walther Oncology; Center, Indiana University School of Medicine, Indianapolis; 46208, USA.
- The in vivo function of Th cell subsets is largely dependent on the ability of differentiated CD4+ T cells to be recruited to specific sites and secrete restricted sets of cytokines. In this paper we demonstrate that Th1 and Th2 cells secrete discrete patterns of chemokines, small m.w. cytokines that function as chemo
- Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA.
- J Immunol. 2000 Jul 1;165(1):148-57. Unique Identifier : AIDSLINE MED/20318711
- Liao HX; Montefiori DC; Patel DD; Lee DM; Scott WK; Pericak-Vance M; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA. hliao@duke.edu'
- A 32-bp deletion in CCR5 (CCR5 Delta 32) confers to PBMC resistance to HIV-1 isolates that use CCR5 as a coreceptor. To study this mutation in T cell development, we have screened 571 human thymus tissues for the mutation. We identified 72 thymuses (12.6%) that were heterozygous and 2 (0.35%) that were homozygous for
- Dendritic cells in the induction of protective and nonprotective anticryptococcal cell-mediated immune responses.
- ptors, Cell Surface/ANALYSIS Support, U.S. Gov't, P.H.S. Survival Analysis T-Lymphocytes/IMMUNOLOGY Vaccines, Inactivated/ADMINISTRATION & DOSAGE/IMMUNOLOGY J Immunol. 2000 Jul 1;165(1):158-67. Unique Identifier : AIDSLINE MED/20318712
- Bauman SK; Nichols KL; Murphy JW; Department of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City 73190, USA.
- Epithelial cell-specific laminin 5 is required for survival of early thymocytes.
- J Immunol. 2000 Jul 1;165(1):192-201. Unique Identifier : AIDSLINE MED/20318716
- Kim MG; Lee G; Lee SK; Lolkema M; Yim J; Hong SH; Schwartz RH; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892, USA.; mkim@plaza1.snu.ac.kr
- The gene LamC2 encoding the gamma2 chain of laminin 5, an epithelial cell-specific extracellular matrix protein, was identified in a PCR-based subtracted cDNA library from mouse thymic stromal cells. The mRNA existed in two alternative forms (5.1 and 2.4 kb). The full-length message was highly expressed in SCID thymus
- Systemic administration of agonist peptide blocks the progression of spontaneous CD8-mediated autoimmune diabetes in transgenic mice without bystander damage.
- J Immunol. 2000 Jul 1;165(1):202-10. Unique Identifier : AIDSLINE MED/20318717
- Bercovici N; Heurtier A; Vizler C; Pardigon N; Cambouris C; Desreumaux P; Liblau R; Laboratoire d'Immunologie Cellulaire, Institut National de la; Sante et de la Recherche Medicale CJF 9711, Paris, France.
- Insulin-dependent diabetes is an autoimmune disease targeting pancreatic beta-islet cells. Recent data suggest that autoreactive CD8+ T cells are involved in both the early events leading to insulitis and the late destructive phase resulting in diabetes. Although therapeutic injection of protein and synthetic peptides
- An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts.
- J Immunol. 2000 Jul 1;165(1):247-55. Unique Identifier : AIDSLINE MED/20318722
- Diamond AS; Gill RG; Department of Immunology and Medicine, Childhood Diabetes,; University of Colorado Health Sciences Center, Denver 80262, USA.
- CD8+ T cells have long been considered to be the prototypical cytotoxic lymphocyte subpopulation. However, whether alloreactive CD8+ T cells require traditional cytolytic pathways such as perforin and Fas ligand (FasL) to mediate graft rejection has been a controversial issue. In the present studies, we examined the r
- T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.
- J Immunol. 2000 Jul 1;165(1):25-33. Unique Identifier : AIDSLINE MED/20318695
- Sandberg JK; Franksson L; Sundback J; Michaelsson J; Petersson M; Achour A; Wallin RP; Sherman NE; Bergman T; Jornvall H; Hunt DF; Kiessling R; Karre K; Microbiology and Tumor Biology Center and Department of Medical; Biochemistry and Biophysics, Karolinska Institutet, Stockholm,; Sweden. jsandber@adarc.adarc.org
- Given the flexible nature of TCR specificity, deletion or permanent disabling of all T cells with the capacity to recognize self peptides would severely limit the diversity of the repertoire and the capacity to recognize foreign Ags. To address this, we have investigated the patterns of CD8+ CTL reactivity to a natura
- The HTLV-I tax protein transcriptionally modulates OX40 antigen expression.
- J Immunol. 2000 Jul 1;165(1):263-70. Unique Identifier : AIDSLINE MED/20318724
- Pankow R; Durkop H; Latza U; Krause H; Kunzendorf U; Pohl T; Bulfone-Paus S; Departments of Pathology and Urology, University Hospital; Benjamin Franklin, Free University Berlin, Germany.
- OX40 is a member of the TNF receptor family, expressed on activated T cells. It is the only costimulatory T cell molecule known to be specifically up-regulated in human T cell leukemia virus type-I (HTLV-I)-producing cells. In a T cell line, OX40 surface expression was shown to be induced by HTLV-I Tax alone. To under
- IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection.
- J Immunol. 2000 Jul 1;165(1):364-72. Unique Identifier : AIDSLINE MED/20318737
- Jones DE; Buxbaum LU; Scott P; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia 19104, USA.
- Leishmania amazonensis induces a nonhealing infection in C3H mice, whereas infection with Leishmania major is self-healing. We found that C3H mice infected with L. amazonensis exhibited decreased IL-12 production, which could account for the susceptibility to this organism. However, exogenous IL-12 administration fail
- T cell vaccination in mice with invasive pulmonary aspergillosis.
- J Immunol. 2000 Jul 1;165(1):381-8. Unique Identifier : AIDSLINE MED/20318739
- Cenci E; Mencacci A; Bacci A; Bistoni F; Kurup VP; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.
- Aspergillus fumigatus, an opportunistic fungal pathogen, is responsible for multiple airway diseases of an allergic and a nonallergic nature. In a murine model of invasive pulmonary aspergillosis, resistance is associated with a decreased lung inflammatory pathology and the occurrence of an IL-12-dependent Th1-type re
- Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice.
- J Immunol. 2000 Jul 1;165(1):5-9. Unique Identifier : AIDSLINE MED/20318691
- White DW; Badovinac VP; Kollias G; Harty JT; Interdisciplinary Graduate Program in Immunology, University of; Iowa, Iowa City 52242, USA.
- The mechanisms by which CD8+ T cells mediate immunity against bacterial pathogens remain largely unknown. Perforin-dependent cytolysis plays a role, but is not required for CD8+ T cell-mediated immunity against Listeria monocytogenes. TNF is essential for CD8+ T cell immunity to L. monocytogenes, but the cellular sour
- Mechanism of paclitaxel activity in Kaposi's sarcoma.
- J Immunol. 2000 Jul 1;165(1):509-17. Unique Identifier : AIDSLINE MED/20318754
- Sgadari C; Toschi E; Palladino C; Barillari G; Carlei D; Cereseto A; Ciccolella C; Yarchoan R; Monini P; Sturzl M; Ensoli B; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
- Kaposi s sarcoma (KS) is an angioproliferative disease characterized by proliferation of spindle-shaped cells predominantly of endothelial cell origin, neoangiogenesis, inflammatory cell infiltration, and edema. At least in early stage, KS behaves as a reactive lesion sustained by the action of inflammatory cytokines
- Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
- Unique Identifier : AIDSLINE MED/20318755
- Wagar EJ; Cromwell MA; Shultz LD; Woda BA; Sullivan JL; Hesselton RM; Greiner DL
- Human PBMC engraft in mice homozygous for the severe combined immunodeficiency (Prkdcscid) mutation (Hu-PBL-scid mice). Hu-PBL-NOD-scid mice generate 5- to 10-fold higher levels of human cells than do Hu-PBL-C.B-17-scid mice, and Hu-PBL-NOD-scid beta2-microglobulin-null (NOD-scid-B2mnull) mice support even higher leve
- Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.
- J Immunol. 2000 Jul 1;165(1):533-8. Unique Identifier : AIDSLINE MED/20318757
- Valmori D; Dutoit V; Lienard D; Lejeune F; Speiser D; Rimoldi D; Cerundolo V; Dietrich PY; Cerottini JC; Romero P; Division of Clinical Onco-Immunology, Ludwig Institute for Cancer; Research, Lausanne Branch, University Hospital, Switzerland.; danila.valmori@inst.hospvd.ch
- The assessment of the TCR repertoire expressed by tumor-specific CD8+ T lymphocytes has been hampered to date by the difficulty of targeting the analysis to lymphocytes directed against a single epitope. In the present study we have used fluorescent A2/Melan-A tetramers in conjunction with anti-CD8 and anti-TCR beta-c
- Anti-TCR-specific DNA vaccination demonstrates a role for a CD8+ T cell clone in the induction of allograft tolerance by donor-specific blood transfusion.
- J Immunol. 2000 Jul 1;165(1):96-101. Unique Identifier : AIDSLINE MED/20318704
- Vignes C; Chiffoleau E; Douillard P; Josien R; Peche H; Heslan JM; Usal C; Soulillou JP; Cuturi MC; Institut National de la Sante et de la Recherche Medicale; Unite 437 "Immunointervention dans les allo-et; xeno-transplantations" and Institut de Transplantation et de; Recherche en Transplantation, Nantes, France.
- Donor-specific allograft tolerance can be induced in the adult rat by pregraft donor-specific blood transfusion (DST). This tolerance appeared to be mediated by regulatory cells and to the production of the suppressive cytokine TGF-beta1. A potential immunoregulatory CD8+ clone bearing a Vbeta18-Dbeta1-Jbeta2.7 TCR ge
- Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice.
- J Immunol. 2000 Jul 15;165(2):1022-9. Unique Identifier : AIDSLINE MED/20341707
- Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD; Department of Medicine, Pathology, and Comparative Medicine,; University of Alabama, Birmingham, AL 35294, USA.
- To elucidate the pathogenesis of Helicobacter pylori-associated gastritis, we studied immune responses of C57BL/6J wild-type (WT), SCID, and gene deficient (IFN-gamma-/- and IL-4-/-) mice following infection with a pathogenic isolate of H. pylori (SPM326). During early infection in WT mice, mononuclear and polymorphon
- Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.
- J Immunol. 2000 Jul 15;165(2):1074-81. Unique Identifier : AIDSLINE MED/20341714
- Flano E; Husain SM; Sample JT; Woodland DL; Blackman MA; Department of Immunology, Program in Viral Oncogenesis and Tumor; Immunology, St. Jude Children's Research Hospital, Memphis, TN; 38105, USA.
- Intranasal infection of mice with the murine gamma-herpesvirus MHV-68 results in an acute lytic infection in the lung, followed by the establishment of lifelong latency. Development of an infectious mononucleosis-like syndrome correlates with the establishment of latency and is characterized by splenomegaly and the ap
- Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors.
- J Immunol. 2000 Jul 15;165(2):1082-92. Unique Identifier : AIDSLINE MED/20341715
- Gea-Banacloche JC; Migueles SA; Martino L; Shupert WL; McNeil AC; Sabbaghian MS; Ehler L; Prussin C; Stevens R; Lambert L; Altman J; Hallahan CW; de Quiros JC; Connors M; Laboratories ofImmunoregulation and Allergic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, MD 20892, USA.
- The virus-specific CD8+ T cell responses of 21 HIV-infected patients were studied including a unique cohort of long-term nonprogressors with low levels of plasma viral RNA and strong proliferative responses to HIV Ags. HIV-specific CD8+ T cell responses were studied by a combination of standard cytotoxic T cell (CTL)
- Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes.
- J Immunol. 2000 Jul 15;165(2):1102-10. Unique Identifier : AIDSLINE MED/20341717
- Cameron MJ; Arreaza GA; Grattan M; Meagher C; Sharif S; Burdick MD; Strieter RM; Cook DN; Delovitch TL; Autoimmunity/Diabetes Group, The John P. Robarts Research; Institute, London, Ontario, Canada.
- We investigated the biological role of CC chemokines in the Th1-mediated pathogenesis of spontaneous type I diabetes in nonobese diabetic (NOD) mice. Whereas an elevated ratio of macrophage inflammatory protein-1alpha (MIP-1alpha):MIP-1beta in the pancreas correlated with destructive insulitis and progression to diabe
- CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection.
- J Immunol. 2000 Jul 15;165(2):1111-8. Unique Identifier : AIDSLINE MED/20341718
- Jones ND; Van Maurik A; Hara M; Spriewald BM; Witzke O; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, Oxford, United Kingdom.; nicholas.jones@surgery.ox.ac.uk
- In experimental transplantation, blockade of CD40-CD40 ligand (CD40L) interactions has proved effective at permitting long-term graft survival and has recently been approved for clinical evaluation. We show that CD4+ T cell-mediated rejection is prevented by anti-CD40L mAb therapy but that CD8+ T cells remain fully fu
- Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii.
- J Immunol. 2000 Jul 15;165(2):628-31. Unique Identifier : AIDSLINE MED/20341661
- Yap G; Pesin M; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, MD 20892, USA.
- IL-12 is required for the development of IFN-gamma-dependent resistance to intracellular pathogens but is not thought to play a major role in its maintenance. To directly assess the requirement for continuous IL-12 signaling in long-term cell-mediated immunity, recombinant cytokine was transiently administered to IL-1
- Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes.
- J Immunol. 2000 Jul 15;165(2):632-6. Unique Identifier : AIDSLINE MED/20341662
- Venkataraman C; Schaefer G; Schindler U; Tularik, South San Francisco, CA 94080, USA.
- Development of naive Th cells into Th1 and Th2 effector populations requires coordinated expression of a complex set of genes. In this study, we have identified a novel four-transmembrane domain protein, Chandra, that is differentially expressed in Th1 cells. Chandra expression is observed in STAT4- and IFN-gamma-defi
- Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell.
- J Immunol. 2000 Jul 15;165(2):680-90. Unique Identifier : AIDSLINE MED/20341668
- Kasprowicz DJ; Kohm AP; Berton MT; Chruscinski AJ; Sharpe A; Sanders VM; Departments of Microbiology and Immunology, and Cell Biology,; Neurobiology and Anatomy, Loyola University Medical Center,; Maywood, IL 60153, USA.
- Our findings using B cells from either wild-type, CD86-deficient, or beta 2-adrenergic receptor (beta2AR)-deficient mice suggest three mechanisms by which the level of IgG1 and IgE production can be increased on a per cell basis. Trinitrophenyl-specific B cells enriched from unimmunized mouse spleens were pre-exposed
- Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells.
- J Immunol. 2000 Jul 15;165(2):716-24. Unique Identifier : AIDSLINE MED/20341672
- Jourdan P; Vendrell JP; Huguet MF; Segondy M; Bousquet J; Pene J; Yssel H; Institut National de la Sante et de la Recherche Medicale Unite; 454, Montpellier, France.
- In the present study, we show that IL-2 , IL-4, IL-7, and IL-15 are able to induce functional CXCR4 surface expression on resting in vitro-generated CD4+ CXCR4- CCR7+ memory T cells. Cytokine-mediated induction of CXCR4 expression was associated with an increase in CXCR
- Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow.
- J Immunol. 2000 Jul 15;165(2):725-33. Unique Identifier : AIDSLINE MED/20341673
- Kohm AP; Tang2 Y; Sanders VM; Jones3 SB; Department of Cell Biology, The Burn and Shock Trauma Institute,; Loyola University Medical Center, Maywood, IL 60153, USA.
- The neurotransmitter norepinephrine (NE) binds to the beta 2-adrenergic receptor (beta 2AR) expressed on various immune cells to influence cell homing, proliferation, and function. Previous reports showed that NE stimulation of the B cell beta 2AR is necessary for the maintenance of an optimal primary and secondary Th
- Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization.
- J Immunol. 2000 Jul 15;165(2):750-9. Unique Identifier : AIDSLINE MED/20341676
- Kumaraguru U; Rouse RJ; Nair SK; Bruce BD; Rouse BT; Department of Microbiology, University of Tennessee, Knoxville,; TN 37996, USA.
- Immunization with plasmid DNA holds promise as a vaccination strategy perhaps useful in situations that currently lack vaccines, since the major means of immune induction may differ from more conventional approach. In the present study, we demonstrate that exposure of macrophages to plasmid DNA encoding viral proteins
- IL-12 is required to maintain a Th1 response during Leishmania major infection.
- J Immunol. 2000 Jul 15;165(2):896-902. Unique Identifier : AIDSLINE MED/20341692
- Park AY; Hondowicz BD; Scott P; Department of Pathobiology, University of Pennsylvania School of; Veterinary Medicine, Philadelphia, PA 19104, USA.
- IL-12 initiates Th1 cell development and cell-mediated immunity, but whether IL-12 contributes to the maintenance of a Th1 response is unclear. To address this question, we infected IL-12 p40-/- C57BL/6 mice with Leishmania major, an intracellular protozoan parasite controlled by a cell-mediated immune response, and s
- Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.
- J Immunol. 2000 Jul 15;165(2):915-24. Unique Identifier : AIDSLINE MED/20341694
- Gurunathan S; Stobie L; Prussin C; Sacks DL; Glaichenhaus N; Fowell DJ; Locksley RM; Chang JT; Wu CY; Seder RA; Clinical Immunology Section, Laboratory of Clinical; Investigation, National Institute of Allergy and Infectious; Diseases, Niational Institutes of Health, Bethesda, MD 20892,; USA.
- Protective immunity against Leishmania major generated by DNA encoding the LACK (Leishmania homologue of receptor for activated C kinase) Ag has been shown to be more durable than vaccination with LACK protein plus IL-12. One mechanism to account for this may be the selective ability of DNA vaccination to induce CD8+
- Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction.
- J Immunol. 2000 Jul 15;165(2):925-30. Unique Identifier : AIDSLINE MED/20341695
- Lewinsohn DM; Briden AL; Reed SG; Grabstein KH; Alderson MR; Division of Pulmonary and Critical Care Medicine, Oregon Health; Sciences, University/Portland Veterans Affairs Medical Center,; Portland, OR 97201, USA. lewinsod@OHSU.edu
- Previous studies in mice and humans models have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). In humans, CD8+ Mtb-reactive T cells have been described that are HLA-A2-, B52-, as well as CD1-restricted. Recently, we have described Mtb-specific CD8+ T cells that are ne
- IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.
- J Immunol. 2000 Jul 15;165(2):941-7. Unique Identifier : AIDSLINE MED/20341697
- Kawakami K; Koguchi Y; Qureshi MH; Miyazato A; Yara S; Kinjo Y; Iwakura Y; Takeda K; Akira S; Kurimoto M; Saito A; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; kawakami@med.u-ryukyu.ac.jp
- The aim of this study was to examine the contribution of IL-18 in host defense against infection caused by Cryptococcus neoformans in mice with defective IL-12 production. Experiments were conducted in mice with a targeted disruption of the gene for IL-12p40 subunit (IL-12p40-/- mice). In these mice, host resistance w
- Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen.
- J Immunol. 2000 Jul 15;165(2):956-61. Unique Identifier : AIDSLINE MED/20341699
- Ohta A; Sekimoto M; Sato M; Koda T; Nishimura S; Iwakura Y; Sekikawa K; Nishimura T; Division of Immunoregulation, Section of Disease Control,; Institute for Genetic Medicine, and Division of Biological; Sciences, Graduate School of Science, Hokkaido University,; Sapporo, Japan.
- We report the development and characterization of a novel model of severe hepatitis induced against hepatitis B virus surface Ag (HBsAg). HBsAg was successfully targeted into the liver in soluble form. Using this unique property of HBsAg, we established a liver injury model induced by HBsAg-specific Th1 cells. Severe
- Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity.
- J Immunol Methods. 2000 Jun 23;240(1-2):143-55. Unique Identifier : AIDSLINE MED/20314647
- Rininsland FH; Helms T; Asaad RJ; Boehm BO; Tary-Lehmann M; Institute of Pathology, School of Medicine, Case Western Reserve; University, Cleveland, OH 44106, USA.
- A major goal in immunodiagnostics has been the development of assay systems that can measure CD8(+) T cell immunity in humans, directly ex vivo, at high resolution, and with high throughput. We established granzyme B (grB) enzyme-linked immunospot assay (ELISPOT) in conjunction with image analysis to this end. Using g
- Pain and pain treatment in AIDS patients: a longitudinal study.
- Unique Identifier : AIDSLINE MED/20330185
- Frich LM; Borgbjerg FM
- To determine the prevalence, incidence, and characteristics of pain connected with AIDS, 95 AIDS patients were enrolled in a prospective longitudinal study and interviewed every six months during a 2-year period or until death. The overall incidence of pain was 88%, and 69% of the patients suffered from constant pain
- T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.
- J Exp Med. 2000 Jun 5;191(11):1869-79. Unique Identifier : AIDSLINE MED/20298894
- Yamashita M; Katsumata M; Iwashima M; Kimura M; Shimizu C; Kamata T; Shin T; Seki N; Suzuki S; Taniguchi M; Nakayama T; Department of Developmental Immunology, Chiba University School; of Medicine, Japan.
- The activation of downstream signaling pathways of both T cell receptor (TCR) and interleukin 4 receptor (IL-4R) is essential for T helper type 2 (Th2) cell development, which is central to understanding immune responses against helminthic parasites and in allergic and autoimmune diseases. However, little is known abo
- Effects of in vivo CD8(+) T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine.
- J Exp Med. 2000 Jun 5;191(11):1921-31. Unique Identifier : AIDSLINE MED/20298898
- Metzner KJ; Jin X; Lee FV; Gettie A; Bauer DE; Di Mascio M; Perelson AS; Marx PA; Ho DD; Kostrikis LG; Connor RI; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, NY 10016, USA.
- The role of CD8(+) T lymphocytes in controlling replication of live, attenuated simian immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the correlates of protection in the SIV/rhesus macaque model. Rhesus macaques immunized for >2 yr with nef-deleted SIV (SIVmac239Deltanef) and prote
- Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.
- J Exp Med. 2000 Jun 5;191(11):1987-97. Unique Identifier : AIDSLINE MED/20298904
- Riley JL; Schlienger K; Blair PJ; Carreno B; Craighead N; Kim D; Carroll RG; June CH; Department of Molecular and Cellular Engineering, University of; Pennsylvania, Philadelphia 19104, USA.
- CD4 T cells activated in vitro by anti-CD3/28-coated beads are resistant to infection by CC chemokine receptor 5 (CCR5)-dependent HIV-1 isolates. In vivo, antigen-presenting cells (APCs) activate CD4 T cells in part by signaling through the T cell receptor and CD28, yet cells stimulated in this manner are susceptible
- Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIV(R29) isolate.
- J Gen Virol. 2000 Jun;81 Pt 6:1463-72. Unique Identifier : AIDSLINE MED/20273992
- Carpenter S; Vaughn EM; Yang J; Baccam P; Roth JA; Wannemuehler Y; Department of Veterinary Microbiology and Preventive Medicine,; College of Veterinary Medicine, Interdepartmental Genetics; Program, Iowa State University, Ames, IA 50011, USA.; scarp@iastate.edu
- Experimental infection of cattle with bovine immunodeficiency virus (BIV) is characterized by persistent, low levels of virus replication in the absence of clinical disease. A virus neutralization (VN) assay was developed to examine the role of VN antibodies in controlling virus replication in cattle experimentally in
- Phase II evaluation of thalidomide in patients with metastatic breast cancer.
- Unique Identifier : AIDSLINE MED/20355117
- Baidas SM; Winer EP; Fleming GF; Harris L; Pluda JM; Crawford JG; Yamauchi H; Isaacs C; Hanfelt J; Tefft M; Flockhart D; Johnson MD; Hawkins MJ; Lippman ME; Hayes DF
- PURPOSE: To determine the efficacy, safety, pharmacokinetics, and effect on serum angiogenic growth factors of two dose levels of thalidomide in patients with metastatic breast cancer. PATIENTS
- Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1.
- J Pediatr. 2000 Jul;137(1):78-84. Unique Identifier : AIDSLINE MED/20351503
- Madhi SA; Schoub B; Simmank K; Blackburn N; Klugman KP; SAIMR/Wits/MRC Pneumococcal Diseases Research Unit, National; Institute for Virology, the Department of Paediatrics, Chris; Hani-Baragwanath Hospital, University of the Witwatersrand,; Johannesburg, South Africa.
- OBJECTIVES: To determine the burden of viral associated severe lower respiratory tract infections (SLRTI) in human immunodeficiency virus-infected (HIV+) and HIV-uninfected (HIV-) urban black South African children. METHODS: Children with SLRTI aged 2 to 60 months were enrolled between March 1997 and March 1998. Monoc
- Prenatal indicators of congenital cytomegalovirus infection [see comments]
- J Pediatr. 2000 Jul;137(1):90-5. Unique Identifier : AIDSLINE MED/20351505
- Lazzarotto T; Varani S; Guerra B; Nicolosi A; Lanari M; Landini MP; Department of Clinical and Experimental Medicine, the University; of Bologna, Italy.
- OBJECTIVE: To assess the validity of a diagnostic protocol designed to predict the outcome of newborns of mothers suspected to have primary cytomegalovirus ( CMV ) infection during the first 4 months of pregnancy. STUDY DESIGN:
- Pediatric home care: reimbursement and cost benefit analysis.
- J Pediatr Health Care. 1999 Nov-Dec;13(6 Pt 1):288-94. Unique Identifier : AIDSLINE MED/20348117
- Balinsky W; Milano Graduate School of Management, Health Services Management; and Policy, New School University, New York, NY, USA.
- Home care has been described as the fastest growing component of personal health care spending, and pediatric home care as the fastest growing segment of the home care field. Because of the continued progress in pediatric medicine and advances in technology, a growing population of children with complex chronic and te
- Transport of cosalane-a highly lipophilic novel anti-HIV agent-across caco-2 cell monolayers.
- J Pharm Sci. 2000 Jun;89(6):826-33. Unique Identifier : AIDSLINE MED/20285423
- Pal D; Udata C; Mitra AK; Division of Pharmaceutical Sciences, School of Pharmacy,; University of Missouri-Kansas City, 5005 Rockhill Road, Kansas; City, Missouri 64110, USA.
- Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral bioavailability of this highly lipophilic compound is extremely poor (
- Biotypes of oral Candida albicans isolated from AIDS patients and HIV-free subjects in Thailand.
- J Oral Pathol Med. 2000 May;29(5):193-9. Unique Identifier : AIDSLINE MED/20258973
- Teanpaisan R; Nittayananta W; Chongsuvivatwong V; Department of Stomatology, Faculty of Dentistry, Prince of; Songkla University, Hat-Yai, Thailand.
- This study was conducted to examine biotypes and antifungal susceptibility patterns of oral Candida albicans isolated from HIV-infected patients, HIV-free patients with candidiasis and healthy subjects. All isolates were biotyped using a typing system based on enzyme profiles, carbohydrate assimilation patterns and bo
- Discriminative immunophenotype of bronchoalveolar lavage CD4 lymphocytes in sarcoidosis.
- Lab Invest. 2000 Jul;80(7):1065-9. Unique Identifier : AIDSLINE MED/20363443
- Kolopp-Sarda MN; Kohler C; De March AK; Bene MC; Faure G; Laboratoire d'Immunologie, Faculte de Medecine and CHU de; Nancy, France. mkolopps@grip.u-nancy.fr
- The diagnosis of pulmonary sarcoidosis relies in part on the observation of alveolar CD4+ lymphocytosis. However, this criterion is not fully discriminative because this anomaly is also found in other types of lung diseases. Among other possible distinctive criteria, we investigated the expression of lymphocyte-addres
- Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor).
- Lab Invest. 2000 Jul;80(7):1121-6. Unique Identifier : AIDSLINE MED/20363450
- Gomez-Roman JJ; Ocejo-Vinyals G; Sanchez-Velasco P; Nieto EH; Leyva-Cobian F; Val-Bernal JF; Departamento de Anatomia Patologica, Hospital Universitario; Marques de Valdecilla, Instituto Nacional de la Salud, Facultad; de Medicina, Universidad de Cantabria, Santander, Spain.
- Inflammatory myofibroblastic tumor (IMT) is composed of myofibroblasts, plasma cells, and lymphocytes. Cytokines are possibly involved in its pathogenesis. Human herpesvirus-8 (HHV-8) encodes cell cycle regulatory and signaling proteins. A combination of nested PCR with several negative controls and Southern blot meth
- Flow cytometric study of lymphocytes associated with thymoma and other thymic tumors.
- J Surg Res. 1999 Apr;82(2):312-8. Unique Identifier : AIDSLINE MED/99192629
- Fujii Y; Okumura M; Yamamoto S; Department of Surgery II, Nagoya City University Medical School,; Nagoya, Japan. yosfujii@med.nagoya-cu.ac.jp
- BACKGROUND. A large number of immature T lymphocytes in thymoma may reflect the biological function of the neoplastic epithelial cells. However, to confirm that this lymphocyte-inducing activity is unique to thymoma, lymphocytes associated with other thymic tumors need to be studied. MATERIALS AND METHODS. We used flo
- Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma.
- Lancet. 2000 May 13;355(9216):1680-3. Unique Identifier : AIDSLINE MED/20361178
- Gereda JE; Leung DY; Thatayatikom A; Streib JE; Price MR; Klinnert MD; Liu AH; Division of Pediatric Allergy & Immunology, National Jewish; Medical & Research Center, Denver, CO 80206, USA.
- BACKGROUND: Bacterial endotoxin is known to induce interferon gamma and interleukin 12 production, and therefore has the potential to decrease allergen sensitisation. To find out the role of early chronic endotoxin exposure in the development of allergen sensitisation and asthma, we compared concentrations of endotoxi
- Tanzanian AIDS project works towards "good things for young people" [news]
- Lancet. 2000 May 13;355(9216):1703. Unique Identifier : AIDSLINE MED/20361189
- Fox R
- Ireland's infected blood products inquiry begins [news]
- Lancet. 2000 May 13;355(9216):1705. Unique Identifier : AIDSLINE MED/20361191
- Birchard K
- HIV in Latin America and the Caribbean [editorial] [published erratum appears in Lancet 2000 Aug 12;356(9229):600]
- Lancet. 2000 Jun 17;355(9221):2087. Unique Identifier : AIDSLINE MED/20358410
- Extent to which low-level use of antiretroviral treatment could curb the AIDS epidemic in sub-Saharan Africa [see comments]
- Lancet. 2000 Jun 17;355(9221):2095-100. Unique Identifier : AIDSLINE MED/20358417
- Wood E; Braitstein P; Montaner JS; Schechter MT; Tyndall MW; O'Shaughnessy MV; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.
- BACKGROUND: Despite growing international pressure to provide HIV-1 treatment to less-developed countries, potential demographic and epidemiological impacts have yet to be characterised. We modelled the future impact of antiretroviral use in South Africa from 2000 to 2005. METHODS
- Promotion of condom use in a high-risk setting in Nicaragua: a randomised controlled trial [see comments]
- Lancet. 2000 Jun 17;355(9221):2101-5. Unique Identifier : AIDSLINE MED/20358418
- Egger M; Pauw J; Lopatatzidis A; Medrano D; Paccaud F; Smith GD; Department of Social Medicine, University of Bristol, UK.; m.egger@bristol.ac.uk
- BACKGROUND: In Latin America, motels rent rooms for commercial and non-commercial sex. We investigated the impact of providing health-education material and condoms on condom use in Managua, Nicaragua . METHODS: In a randomised controlled trial, in 19 motels, we gave condoms on r
- 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial.
- Lancet. 2000 Jun 17;355(9221):2106-11. Unique Identifier : AIDSLINE MED/20358419
- French N; Nakiyingi J; Carpenter LM; Lugada E; Watera C; Moi K; Moore M; Antvelink D; Mulder D; Janoff EN; Whitworth J; Gilks CF; Liverpool School of Tropical Medicine, UK.
- BACKGROUND: Infection with Streptococcus pneumoniae is a frequent and serious problem for HIV-immunosuppressed adults. Vaccination is recommended in the USA and Europe, but there are no prospective data that show vaccine efficacy. METHODS: 1392 (937 female) HIV-1-infected adults in Entebbe,
- Pharmacological implications of lengthened in-utero exposure to nevirapine [letter]
- Lancet. 2000 Jun 17;355(9221):2134-5. Unique Identifier : AIDSLINE MED/20358425
- Taylor GP; Lyall EG; Back D; Ward C; Tudor-Williams G
- Given as a single dose to the mother during labour, nevirapine can protect the neonate from HIV-1 infection for up to 7 days. However, after maternal nevirapine therapy during pregnancy, neonatal plasma concentrations of nevirapine decline more rapidl
- Hit HIV-1 hard, but only when necessary [see comments]
- Lancet. 2000 Jun 17;355(9221):2147-52. Unique Identifier : AIDSLINE MED/20358438
- Harrington M; Carpenter CC; Treatment Action Group, New York, NY 10001, USA.; markharrington@aol.com
- Randomised, controlled trial data show that combination antiretroviral therapy for HIV-1 infection benefits people with CD4-cell counts less than 350 cells/microL. Based on currently known risks and benefits, we believe that if CD4-cell counts and viral load are monitored carefully, and highly active antiretroviral th
- The debate on HIV in Africa [letter; comment]
- Lancet. 2000 Jun 17;355(9221):2162. Unique Identifier : AIDSLINE MED/20358441
- Clumeck N
- The debate on HIV in Africa [letter; comment]
- Lancet. 2000 Jun 17;355(9221):2162. Unique Identifier : AIDSLINE MED/20358442
- O'Farrell N
- The debate on HIV in Africa [letter; comment]
- Lancet. 2000 Jun 17;355(9221):2162-3. Unique Identifier : AIDSLINE MED/20358443
- Stewart GT; de Harvey E; Fiala C; Herxheimer A; Kohntein K
- The debate on HIV in Africa [letter]
- Lancet. 2000 Jun 17;355(9221):2163. Unique Identifier : AIDSLINE MED/20358444
- Sonnabend J
- Cochlear implantation in auditory neuropathy.
- Laryngoscope. 1999 Feb;109(2 Pt 1):181-5. Unique Identifier : AIDSLINE MED/20346816
- Miyamoto RT; Kirk KI; Renshaw J; Hussain D; Department of Otolaryngology--Head and Neck Surgery, Indiana; University School of Medicine, Indianapolis 46202, USA.
- OBJECTIVE: Auditory neuropathy is a recently described clinical entity characterized by sensorineural hearing loss in which the auditory evoked potential (ABR) is absent but otoacoustic emissions are present. This suggests a central locus for the associated hearing loss. In this study the results observed in a child w
- Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type-1 (HIV-1).
- Microbiol Immunol. 2000;44(2):105-10. Unique Identifier : AIDSLINE MED/20260633
- Yu T; Bai Y; Dierich MP; Chen YH; Laboratory of Immunology, Research Center for Medical Science and; the School of Life Science and Engineering, Tsinghua University,; Beijing, PR China.
- To test the immunogenicity of GPGRAFY-epitope-based candidate vaccines, a peptide with four repetitive GPGRAFY epitopes, V3-P1 [C-(GPGRAFY)4], and a peptide (PND) of the principal neutralizing domain (V3 loop: amino acid 301-328: C-TRPNNNTRKSIRIQRGPGRAFYTIGKI) on gp120 were synthesized and covalently coupled to a carr
- Exposure of normal monocyte-derived dendritic cells to human immunodeficiency virus type-1 particles leads to the induction of apoptosis in co-cultured CD4+ as well as CD8+ T cells.
- Microbiol Immunol. 2000;44(2):111-21. Unique Identifier : AIDSLINE MED/20260634
- Suzuki S; Tobiume M; Kameoka M; Sato K; Takahashi TA; Mukai T; Ikuta K; Section of Serology, Institute of Immunological Science, Hokkaido; University, Sapporo, Japan.
- The depletion of immune T cells by human immunodeficiency virus type-1 (HIV-1) infection is a major mechanism involved in the pathogenesis of AIDS. Here, we examined a possible effector function of blood monocyte-derived dendritic cells (DCs) to induce apoptosis in bystander CD4+ and CD8+ T cells. The DCs were generat
- National HIV Testing Day at CDC-funded HIV counseling, testing, and referral sites--United States, 1994-1998.
- MMWR Morb Mortal Wkly Rep. 2000 Jun 23;49(24):529-32. Unique Identifier : AIDSLINE MED/20378374
- CDC-funded human immunodeficiency virus (HIV) counseling, testing, and referral sites are an integral part of national HIV prevention efforts (1). Voluntary counseling, testing, and referral opportunities are offered to persons at risk for HIV infection at approximately 11,000 sites, including dedicated HIV counseling
- Gonorrhea--United States, 1998.
- MMWR Morb Mortal Wkly Rep. 2000 Jun 23;49(24):538-42. Unique Identifier : AIDSLINE MED/20378377
- Neisseria gonorrhoeae infections are a major cause of pelvic inflammatory disease, infertility, and ectopic pregnancy in women and facilitate the transmission of human immunodeficiency virus (1). To characterize the epidemiology of gonorrhea in the United States , CDC examined national
- [Design of virus-like particles, exposing HIV-1 epitopes]
- Mol Biol (Mosk). 2000 May-Jun;34(3):480-5. Unique Identifier : AIDSLINE MED/20325881
- Lebedev LR; Karpenko LI; Poryvaeva VA; Azaev MSh; Riabchikova EI; Gileva IP; Il'ichev AA; vector@vector.nsk.su
- Smoking and pneumococcal disease [letter]
- N Engl J Med. 2000 Jul 20;343(3):219-20. Unique Identifier : AIDSLINE MED/20344364
- Fleming CA; Craven DE
- Herpes zoster [letter]
- N Engl J Med. 2000 Jul 20;343(3):222-3. Unique Identifier : AIDSLINE MED/20344369
- Breton G; Bricaire F; Caumes E
- Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23-2000. A 49-year-old man with acquired immunodeficiency syndrome and a tibial lesion [clinical conference]
- N Engl J Med. 2000 Jul 27;343(4):281-7. Unique Identifier : AIDSLINE MED/20350567
- Spontaneous pneumothorax [letter]
- N Engl J Med. 2000 Jul 27;343(4):300; discussion 300-1. Unique Identifier : AIDSLINE MED/20350575
- Taylor G
- HIV-1 and an HTLV-II-associated cutaneous T-cell lymphoma [letter]
- N Engl J Med. 2000 Jul 27;343(4):303-4. Unique Identifier : AIDSLINE MED/20350580
- Guitart J
- The ethics of research in developing countries [letter]
- N Engl J Med. 2000 Aug 3;343(5):361-2; discussion 363. Unique Identifier : AIDSLINE MED/20362847
- Gray RH; Quinn TC; Serwadda D; Sewankambo NK; Wabwire-Mangen F; Wawer MJ
- The ethics of research in developing countries [letter]
- N Engl J Med. 2000 Aug 3;343(5):362; discussion 363. Unique Identifier : AIDSLINE MED/20362849
- Greco DB
- The ethics of research in developing countries [letter]
- N Engl J Med. 2000 Aug 3;343(5):362; discussion 363. Unique Identifier : AIDSLINE MED/20362848
- Mullings AM
- The ethics of research in developing countries [letter]
- N Engl J Med. 2000 Aug 3;343(5):362-3. Unique Identifier : AIDSLINE MED/20362850
- Hearst N
- The ethics of research in developing countries [letter]
- N Engl J Med. 2000 Aug 3;343(5):363. Unique Identifier : AIDSLINE MED/20362851
- Cates W Jr; Coates TJ
- The ethics of research in developing countries [letter]
- N Engl J Med. 2000 Aug 3;343(5):363. Unique Identifier : AIDSLINE MED/20362852
- Handsfield HH
- A study in rural Uganda of heterosexual transmission of human immunodeficiency virus [letter]
- N Engl J Med. 2000 Aug 3;343(5):364; discussion 364-5. Unique Identifier : AIDSLINE MED/20362853
- Bailey RC
- A study in rural Uganda of heterosexual transmission of human immunodeficiency virus [letter]
- N Engl J Med. 2000 Aug 3;343(5):364; discussion 364-5. Unique Identifier : AIDSLINE MED/20362854
- Fremont-Smith K
- A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis.
- Nature. 2000 Jun 22;405(6789):962-6. Unique Identifier : AIDSLINE MED/20335886
- Stover CK; Warrener P; VanDevanter DR; Sherman DR; Arain TM; Langhorne MH; Anderson SW; Towell JA; Yuan Y; McMurray DN; Kreiswirth BN; Barry CE; Baker WR; PathoGenesis Corporation, Seattle, Washington 98119, USA.; kstover@pathogenesis.com
- Mycobacterium tuberculosis, which causes tuberculosis, is the greatest single infectious cause of mortality worldwide, killing roughly two million people annually. Estimates indicate that one-third of the world population is infected with latent M. tuberculosis. The synergy between tuberculosis and the AIDS epidemic,
- Declaration for AIDS sufferers [editorial]
- Nature. 2000 Jul 6;406(6791):1. Unique Identifier : AIDSLINE MED/20351002
- Unrealistic promises on AIDS fuel scepticism [letter]
- Nature. 2000 Jul 6;406(6791):13. Unique Identifier : AIDSLINE MED/20351017
- Dorritie D
- The Durban Declaration.
- Nature. 2000 Jul 6;406(6791):15-6. Unique Identifier : AIDSLINE MED/20351018
- African scientists join colleagues in affirming HIV's role in AIDS...but advisory panel remains divided [news]
- Nature. 2000 Jul 6;406(6791):3. Unique Identifier : AIDSLINE MED/20351003
- Cherry M
- Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin.
- Nature. 2000 Jul 6;406(6791):82-6. Unique Identifier : AIDSLINE MED/20351044
- May C; Rivella S; Callegari J; Heller G; Gaensler KM; Luzzatto L; Sadelain M; Department of Human Genetics, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021, USA.
- The stable introduction of a functional beta-globin gene in haematopoietic stem cells could be a powerful approach to treat beta-thalassaemia and sickle-cell disease. Genetic approaches aiming to increase normal beta-globin expression in the progeny of autologous haematopoietic stem cells might circumvent the limitati
- Gastrogate: the ethical responsibilities of doctors and administrators.
- N Z Med J. 2000 Jun 9;113(1111):232-3. Unique Identifier : AIDSLINE MED/20365295
- Gillett GR; Dunedin School of Medicine.
- Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis.
- Ophthalmology. 2000 Jul;107(7):1333-7. Unique Identifier : AIDSLINE MED/20349644
- Avunduk AM; Avunduk MC; Kapicioglu Z; Akyol N; Tavli L; Department of Ophthalmology, Karadeniz Technical University; School of Medicine, Trabzon, Turkey. avunduk@meds.ktu.edu.tr
- PURPOSE: To explore the mechanism of action of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis (VKC) and to compare the efficacy of these drugs to each other. DESIGN: Single-investigator, masked, randomized, clinical trial. PARTICIPANTS: Twenty male and 10 female patients between the ag
- [Etiology of eye diseases, their prevention with special consideration of risk factors]
- Orv Hetil. 2000 Apr 30;141(18):947-57. Unique Identifier : AIDSLINE MED/20291849
- Betko J
- Based on the newest data of literary, sometimes on different handbooks and his own more than 40 years experience, the author summarizes the reasons for developments of the eye diseases and the most often occurring endogen and exogen factors. The summary is justified, because both in diagnosis and in therapy, but espec
- HIV confidentiality law has serious flaws [editorial]
- Pa Med. 2000 May;103(5):6. Unique Identifier : AIDSLINE MED/20328413
- Mills JW
- [Human T-lymphotropic virus type I (HTLV-I): risk of transmission with transfusion]
- Presse Med. 2000 Jun 10;29(20):1134-8. Unique Identifier : AIDSLINE MED/20360253
- Lefrere JJ; Unite de Recherches biocliniques et transfusionnelles, Institut; National de la Transfusion Sanguine, Paris. lefrere@worldnet.fr
- PATHOGENIC ROLE: The human T-lymphotropic virus type I (HTLV-I), the first human retrovirus discovered, is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and of HTLV-I associated myelopathy or tropical spastic paraparesis (HAM/TSP) and has a widespread but uneven worldwide distribution. HTLV-I has a high
- [Dengue or acute retroviral syndrome?]
- Presse Med. 2000 Jun 17;29(21):1173-4. Unique Identifier : AIDSLINE MED/20364242
- Cabie A; Abel S; Lafaye JM; Bera O; Cesaire R; Sobesky G; Centre d'Information et de Soins de l'Immunodeficience Humaine; CISIH, Martinique.
- BACKGROUND: The diagnosis of primary HIV infection is a crucial element in the fight against the AIDS epidemic. Clinical manifestations associated with primary infection are nonspecific. Dengue is a possible differential diagnosis. CASE REPORT: A 15-year-old adolescent living in
- Examining methods for calculations of binding free energies: LRA, LIE, PDLD-LRA, and PDLD/S-LRA calculations of ligands binding to an HIV protease.
- Proteins. 2000 Jun 1;39(4):393-407. Unique Identifier : AIDSLINE MED/20274084
- Sham YY; Chu ZT; Tao H; Warshel A; Chemistry Department, University of Southern California, Los; Angeles, California 90089-1062, USA.
- Several strategies for evaluation of the protein-ligand binding free energies are examined. Particular emphasis is placed on the Linear Response Approximation (LRA) (Lee et. al., Prot Eng 1992;5:215-228) and the Linear Interaction Energy (LIE) method (Aqvist et. al., Prot Eng 1994;7:385-391). The performance of the Pr
- Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice.
- Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7078-83. Unique Identifier : AIDSLINE MED/20318983
- Ing R; Su Z; Scott ME; Koski KG; Institute of Parasitology and School of Dietetics and Human; Nutrition, McGill University (Macdonald Campus), 21,111 Lakeshore; Road, Ste-Anne de Bellevue, Quebec H9X 3V9, Canada.
- Protein malnutrition may increase susceptibility to gastrointestinal parasitic infections, possibly as a result of impaired intestinal and/or systemic T helper 2 (Th2) effector responses induced by down-regulation of Th2 cytokines and/or up-regulation of Th1 cytokines. To test this hypothesis, female BALB/c mice (n =
- Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells.
- Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7452-7. Unique Identifier : AIDSLINE MED/20319047
- Neuhaus O; Farina C; Yassouridis A; Wiendl H; Then Bergh F; Dose T; Wekerle H; Hohlfeld R; Department of Neuroimmunology, Max Planck Institute of; Neurobiology, Am Klopferspitz 18A, 82152 Martinsried, Germany.
- Copolymer 1 (COP), a standardized mixture of synthetic polypeptides consisting of l-glutamic acid, l-lysine, l-alanine, and l-tyrosine, has beneficial effects in multiple sclerosis and experimental autoimmune encephalomyelitis. We selected a panel of 721 COP-reactive T cell lines (TCL) from the blood of COP-treated an
- Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.
- Unique Identifier : AIDSLINE GENBANK/U83661
- Wijnholds J; Mol CA; van Deemter L; de Haas M; Scheffer GL; Baas F; Beijnen JH; Scheper RJ; Hatse S; De Clercq E; Balzarini J; Borst P; Division of Molecular Biology and Center for Biomedical Genetics,; The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX; Amsterdam, The Netherlands.
- Two prominent members of the ATP-binding cassette superfamily of transmembrane proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), can mediate the cellular extrusion of xenobiotics and (anticancer) drugs from normal and tumor cells. The MRP subfamily consists of at least s
- Postoperative administration of interleukin-12 significantly enhances the anti-tumor immune response of MBT-2 bladder cancer bearing mice.
- Proc Natl Sci Counc Repub China B. 2000 Apr;24(2):56-62. Unique Identifier : AIDSLINE MED/20267078
- Tzai TS; Shiau AL; Wu CL; Tsai YS; Department of Urology, National Cheng Kung University, Tainan,; Taiwan, ROC.
- This study, using the MBT-2 murine bladder tumor model, mainly investigated the role of interleukin-12 (IL-12) in the specific antitumor immune response of a tumor-bearing host when systemically administrated after surgery. Day 17 tumor-bearing mice (D17TBM) along with non-tumor bearing naive mice were treated with da
- [Knowledge, attitudes, and practice regarding occupational risk of exposure to HIV among medical students at the Medical School of the Federal University of Minas Gerais]
- Rev Soc Bras Med Trop. 1999 Sep-Oct;32(5):509-15. Unique Identifier : AIDSLINE MED/20343749
- Toledo Junior AC; Ribeiro FA; Ferreira FG; Ferraz RM; Greco DB; Departamento de Clinica Medica, Faculdade de Medicina da; Universidade Federal de Minas Gerais, Belo Horizonte.; toledoac@task.com.br
- The objectives of this study were to evaluate the occupational risk of medical students, their knowledge and practice of universal biosafety measures and hepatitis B immunization coverage. A specific questionnaire was applied to 136 medical students of the Universidade Federal de Minas Gerais: 87 (64%) students were i
- [Determination of the minimum inhibitory concentration of fluconazole against Cryptococcus neoformans]
- Rev Cubana Med Trop. 1999 Jan-Apr;51(1):55-7. Unique Identifier : AIDSLINE MED/20345770
- Fernandez Andreu CM; Pimentel Turino T; Martinez Machin G; Gonzalez Miranda M; ciipk@infomed.sld.cu
- The minimum inhibitory concentration of fluconozole was determined in 36 strains of Cryptococcus neoformans var. neoformans by a casitone broth microdilution method, taking into account that it is one of the most used antifungal agents in our country for the treatment of cryptococcal meningitis, the second opportunist
- [Report of a case of purulent rhinitis caused by Streptococcus pneumoniae in a patient with HIV/AIDS]
- Rev Cubana Med Trop. 1999 May-Aug;51(2):125-7. Unique Identifier : AIDSLINE MED/20345784
- Cabrera Cantelar N; Menendez Capote R; Perez Monras M; Medina Almenares V; de Francisco NC; Perez Avila J
- This paper reports a case of acute purulent rhinitis caused by Streptococcus pneumoniae in a HIV/AIDS patient seen at the Hospitalization Center of Pedro Kouri Tropical Medicine Institute. The clinical findings were fever, severe purulent rhinorrea and affected general condition. Streptococcus pneumoniae was isolate
- [Assessment of an ELISA for the detection of antibodies against HIV-1 protein p24]
- Rev Cubana Med Trop. 1999 May-Aug;51(2):130-2. Unique Identifier : AIDSLINE MED/20345786
- Ribas Antunez MA; Silva Cabrera E; Resik Aguirre S; Rodriguez Valdes C; Torano Canto I; ciipk@infomed.sld.cu
- DAVIH AC p24 kit for detecting anti p24 antibodies of HIV-1, worked out by the National Laboratory of Reference of AIDS (Labor-1, Cuba ) is assessed and results are compared to those of the Western Blot technique (DAVIH-Blot, Labor-1, Cuba). 191 samples from HIV positive patients at v
- Depressive symptoms among African American women with HIV disease.
- Sch Inq Nurs Pract. 2000 Spring;14(1):9-39; discussion 41-6. Unique Identifier : AIDSLINE MED/20343774
- Moneyham L; Sowell R; Seals B; Demi A; University of South Carolina, USA.
- Depressive symptoms are a common response to HIV disease and evidence suggests that women may be at particular risk. Very little of the research on depressive symptoms within the context of HIV disease has included women, however, and even fewer studies have targeted African American women. In a beginning effort to ad
- Mycetoma in an HIV-infected patient.
- Rev Hosp Clin Fac Med Sao Paulo. 1999 Sep-Oct;54(5):169-71. Unique Identifier : AIDSLINE MED/20251225
- Castro LG; Valente NY; Germano JA; Vaccari EM; da Silva Lacaz C; Division of Dermatology, School of Medicine, University of Sao; Paulo, Sao Paulo, Brazil.
- Although opportunistic fungal infections occur commonly in immunocompromised hosts, mycetoma has never been reported in association with HIV infection. The authors present a case that to their knowledge is the first reported case of mycetoma associated with HIV infection. Diagnosis was confirmed by direct examination
- [Detection of tuberculosis in HIV-positive patients]
- Rev Enferm. 1999 May;22(5):358-60. Unique Identifier : AIDSLINE MED/99444355
- Arranz Alcalde MS; Rodriguez JC
- Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy.
- Scand J Immunol. 2000 Jul;52(1):96-102. Unique Identifier : AIDSLINE MED/20345146
- Dieli F; Singh M; Spallek R; Romano A; Titone L; Sireci G; Friscia G; Di Sano C; Santini D; Salerno A; Ivanyi J; Section of Pathology, Department of Biopathology, University of; Palermo, 90134 Palermo, Italy.
- T cells mediate protection against tuberculosis, but little is known about their role during chemotherapy of patients with active disease. Here we examined the cytokine profile of CD4 T cells before and after four months of chemotherapy in six initial skin test anergic cases. Purified protein derivative (PPD) and 16-k
- AIDS research. Italian scientists seek to reverse budget cuts [news]
- Science. 2000 Jul 7;289(5476):28. Unique Identifier : AIDSLINE MED/20375848
- Balter M
- AIDS in a new millennium.
- Science. 2000 Jul 7;289(5476):64-6. Unique Identifier : AIDSLINE MED/20375854
- Schwartlander B; Garnett G; Walker N; Anderson R; UNAIDS, 20 Avenue Appia, Geneva 27 CH-1211, Switzerland.; schwartlanderb@unaids.org
- Three-dimensional structure of the Tn5 synaptic complex transposition intermediate [see comments]
- Science. 2000 Jul 7;289(5476):77-85. Unique Identifier : AIDSLINE PDB/1F3I
- Davies DR; Goryshin IY; Reznikoff WS; Rayment I; Department of Biochemistry, University of Wisconsin, Madison, WI; 53706, USA.
- Genomic evolution has been profoundly influenced by DNA transposition, a process whereby defined DNA segments move freely about the genome. Transposition is mediated by transposases, and similar events are catalyzed by retroviral integrases such as human immunodeficiency virus-1 (HIV-1) integrase. Understanding how th
- [Malnutrition and infections in children--a destructive interplay with global dimensions]
- Tidsskr Nor Laegeforen. 2000 Jun 10;120(15):1740-5. Unique Identifier : AIDSLINE MED/20362285
- Bohler E; Wathne KO; Barnemedisinsk avdeling Ullev~al sykehus, Oslo.
- BACKGROUND: Seven out of ten deaths among the world s children are caused by infectious diseases. Malnutrition is a contributing cause in more than half of the children s deaths. At present, interventions against such diseases in children are the most cost-effective way of reducing the world s morbidity and mortality.
- CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade.
- Transplantation. 2000 Jun 27;69(12):2609-12. Unique Identifier : AIDSLINE MED/20365654
- Ensminger SM; Witzke O; Spriewald BM; Morrison K; Morris PJ; Rose ML; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, United Kingdom.
- BACKGROUND: The CD40-CD154 receptor-ligand pair plays a critical role in allograft rejection by mediating the activation of endothelial cells, antigen-presenting cells, and T cells. Blockade of this interaction prevents acute allograft rejection and leads to prolonged allograft survival in numerous experimental models
- Preferential induction of Th1 responses by functionally mature hepatic (CD8alpha- and CD8alpha+) dendritic cells: association with conversion from liver transplant tolerance to acute rejection.
- Transplantation. 2000 Jun 27;69(12):2647-57. Unique Identifier : AIDSLINE MED/20365659
- Morelli AE; O'Connell PJ; Khanna A; Logar AJ; Lu L; Thomson AW; Thomas E Starzl Transplantation Institute, and Department of; Surgery, University of Pittsburgh, Pennsylvania, USA.
- BACKGROUND: Liver grafts are accepted across major histocompatibility barriers in mice without immunosuppressive therapy. Potentially tolerogenic immature donor dendritic cells (DC) may play a key role in this phenomenon, but recovery of purified DC from normal livers for functional analysis is inherently difficult. A
- The role of CD4(+) or CD8(+) T cells in the protective immune response of BALB/c mice to Neospora caninum infection.
- Vet Parasitol. 2000 Jun 27;90(3):183-91. Unique Identifier : AIDSLINE MED/20303080
- Tanaka T; Hamada T; Inoue N; Nagasawa H; Fujisaki K; Suzuki N; Mikami T; The Research Center for Protozoan Molecular Immunology, Obihiro; University of Agriculture and Veterinary Medicine, Inada-cho,; Obihiro, 080-8555, Hokkaido, Japan.
- The role of CD4(+) or CD8(+) T cells in the immune response of BALB/c mice against Neospora caninum infection was examined by using anti-CD4 and/or anti-CD8 monoclonal antibodies (mAbs). Mice were intraperitoneally inoculated with anti-CD4 and/or anti-CD8 mAbs before and after infection with N. caninum and observed fo
- Human xenograft models for virus infection.
- Virology. 2000 Jun 5;271(2):215-9. Unique Identifier : AIDSLINE MED/20319104
- Mosier DE; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA. dmosier@scripps.edu
- Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4.
- Virology. 2000 Jun 5;271(2):240-7. Unique Identifier : AIDSLINE MED/20319108
- Kajumo F; Thompson DA; Guo Y; Dragic T; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, NY 10461, USA.
- CXCR4 mediates the fusion and entry of X4 and R5X4 strains of human immunodeficiency virus type 1 (HIV-1). The residues involved in CXCR4 coreceptor function have not all yet been identified, but tyrosine and negatively charged residues in the amino-terminal domain of CCR5 were shown to be indispensable for gp120 bind
- Membrane fusion between retroviral particles: host-range extension and vaccine prospects.
- Virology. 2000 Jun 5;271(2):248-52. Unique Identifier : AIDSLINE MED/20319109
- Sparacio S; Zeilfelder U; Pfeiffer T; Henzler T; Bosch V; Forschungsschwerpunkt Angewandte Tumorvirologie, F0200, Deutsches; Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg,; Germany.
- We have analyzed if different populations of retroviral particles carrying the viral and cellular receptors of membrane viruses, respectively, are able to specifically fuse with each other. Using the glycoprotein of human immunodeficiency virus type 1 and its cellular receptor complex, we demonstrate that interviral m
- Absence of coreceptor switch with disease progression in human immunodeficiency virus infections in India.
- Virology. 2000 Jun 5;271(2):253-8. Unique Identifier : AIDSLINE MED/20319110
- Cecilia D; Kulkarni SS; Tripathy SP; Gangakhedkar RR; Paranjape RS; Gadkari DA; National Institute of Virology, Pune, 411001, India.; cdayaraj@hotmail.com
- The envelope glycoprotein of the human immunodeficiency virus (HIV) utilizes CD4 as a receptor and CCR5 and/or CXCR4 as coreceptor to gain entry into the cell. The CCR5-tropic viruses, observed early in infection, could be important in transmission and the CXCR4-tropic viruses, observed late, may play an important rol
- Antigenic properties of recombinant envelope glycoproteins derived from T-cell-line-adapted isolates or primary human immunodeficiency virus isolates and their relationship to immunogenicity.
- Virology. 2000 Jun 5;271(2):350-62. Unique Identifier : AIDSLINE MED/20319119
- Brand D; Lemiale F; Thibault G; Verrier B; Lebigot S; Roingeard P; Buzelay L; Brunet S; Barin F; Unite de Virologie, Universite Francois Rabelais, Tours,; France. brand@med.univ-tours.fr
- The native envelope glycoproteins of primary HIV-1 virions have weaker antigenicity than do T-cell laboratory-adapted (TCLA) viruses. These antigenic properties require further evaluation if recombinant envelope glycoproteins are produced as part of a vaccine strategy. In this study, we compared the antigenicity of re
- [Progressive hearing loss]
- Wien Med Wochenschr. 2000;150(6):128-31. Unique Identifier : AIDSLINE MED/20352229
- Reiss M; Reiss G; Klinik fur Hals-Nasen-Ohrenheilkunde, Klinikum Gorlitz GmbH,; Deutschland.
- Progressive sensorineural hearing loss (SNHL) is defined as hearing loss of unknown etiology with fairly high-speed progression. Its diagnostic criteria consist of the following: that it is 1) progressive, 2) with bilateral involvement, and 3) of unknown etiology. Due to recent advances in diagnostics, imaging and man
- A comparative study of the effects of two oral contraceptives containing dienogest or desogestrel on the human immune system.
- Gynecol Endocrinol. 2000 Feb;14(1):15-24. Unique Identifier : AIDSLINE MED/20272982
- Klinger G; Graser T; Mellinger U; Moore C; Vogelsang H; Groh A; Latterman C; Klinger G; Clinic of Obstetrics and Gynecology, Friedrich Schiller; University, Jena, Germany.
- The effects of two oral contraceptive combinations, dienogest 2.0 mg plus ethinyl estradiol 0.03 mg (Valette) and desogestrel 0.15 mg plus ethinyl estradiol 0.02 mg (Lovelle), on the human immune system were compared over one treatment cycle of 31 patients (n = 15 and n = 16, respectively). Lovelle but not Valette sig
- Dynamic contrast-enhanced T2-weighted MR imaging of recurrent malignant gliomas treated with thalidomide and carboplatin.
- AJNR Am J Neuroradiol. 2000 May;21(5):881-90. Unique Identifier : AIDSLINE MED/20273086
- Cha S; Knopp EA; Johnson G; Litt A; Glass J; Gruber ML; Lu S; Zagzag D; Department of Radiology, New York University Medical Center, New; York 10016, USA.
- BACKGROUND AND PURPOSE: Dynamic, contrast-enhanced MR imaging has allowed quantitative assessment of cerebral blood volume (CBV) in brain tumors. The purpose of our study was to compare postcontrast T1-weighted imaging with dynamic, contrast-enhanced T2*-weighted echo-planar imaging in the evaluation of the response o
- AIDS Society recommendations for antiretroviral therapy.
- Am Fam Physician. 2000 Jul 1;62(1):179-80, 182. Unique Identifier : AIDSLINE MED/20361723
- Huffman GB
- Cervical neoplasia and repeated positivity of human papillomavirus infection in human immunodeficiency virus-seropositive and -seronegative women.
- Am J Epidemiol. 2000 Jun 15;151(12):1148-57. Unique Identifier : AIDSLINE MED/20361462
- Ahdieh L; Munoz A; Vlahov D; Trimble CL; Timpson LA; Shah K; Department of Epidemiology, School of Hygiene and Public Health,; The Johns Hopkins University, Baltimore, MD 21205, USA.; lahdieh@jhsph.edu
- Increased risk for cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV)-infected women may be explained by repeated positivity of human papillomavirus (HPV) infection facilitated by HIV infection and related immunosuppression. As part of a longitudinal study with semiannual examinations, 268
- Impact of protease inhibitors and other antiretroviral treatments on acquired immunodeficiency syndrome survival in San Francisco, California, 1987-1996.
- Am J Epidemiol. 2000 Jul 15;152(2):178-85. Unique Identifier : AIDSLINE MED/20365310
- Schwarcz SK; Hsu LC; Vittinghoff E; Katz MH; San Francisco Department of Public Health, CA 94102, USA.; Sandy_Schwarcz@dph.sf.ca.us
- The authors assessed temporal trends in acquired immunodeficiency syndrome (AIDS) survival for 15,271 persons in San Francisco, California, diagnosed between 1987 and 1996 with an opportunistic illness included in the 1987 AIDS case definition. Predictors of survival were evaluated for 5,686 persons who were diagnosed
- Randomized controlled trial of audio computer-assisted self-interviewing: utility and acceptability in longitudinal studies. HIVNET Vaccine Preparedness Study Protocol Team.
- Am J Epidemiol. 2000 Jul 15;152(2):99-106. Unique Identifier : AIDSLINE MED/20365300
- Metzger DS; Koblin B; Turner C; Navaline H; Valenti F; Holte S; Gross M; Sheon A; Miller H; Cooley P; Seage GR 3rd; University of Pennsylvania/VA Center for Studies of Addiction,; Philadelphia 19104, USA. metzger@research.trc.upenn.edu
- Recent studies have reported on the utility of audio computer-assisted self-interviewing (ACASI) in surveys of human immunodeficiency virus (HIV) risk behaviors that involve a single assessment. This paper reports the results of a test of ACASI within a longitudinal study of HIV risk behavior and infection. Study part
- The public health challenges of the HIV epidemic [editorial]
- Am J Public Health. 2000 Jul;90(7):1023-4. Unique Identifier : AIDSLINE MED/20355364
- Levi J
- Children and older persons: AIDS' unseen victims [editorial; comment]
- Am J Public Health. 2000 Jul;90(7):1024-5. Unique Identifier : AIDSLINE MED/20355365
- Knodel J; VanLandingham M
- A change in approach to prenatal HIV screening [editorial]
- Am J Public Health. 2000 Jul;90(7):1026-7. Unique Identifier : AIDSLINE MED/20355366
- Kass N
- Ignore AIDS and it will bury the rest of you.
- Am J Public Health. 2000 Jul;90(7):1028. Unique Identifier : AIDSLINE MED/20355367
- Helfand WH; Lazarus J; Theerman P; History of Medicine Division, National Library of Medicine,; Bethesda, Md. 20894, USA.
- HIV prevention research: accomplishments and challenges for the third decade of AIDS.
- Am J Public Health. 2000 Jul;90(7):1029-32. Unique Identifier : AIDSLINE MED/20355368
- Auerbach JD; Coates TJ; Office of AIDS Research, National Institutes of Health, Bethesda,; Md. 20892, USA. auerbacj@od.nih.gov
- The past 2 decades have taught us that HIV prevention can work. We now have evidence from places as diverse as Senegal , Thailand , Uganda , and Australia that concerte
- HIV: challenging the health care delivery system.
- Am J Public Health. 2000 Jul;90(7):1033-6. Unique Identifier : AIDSLINE MED/20355369
- Levi J; Kates J; Center for Health Services Research and Policy, George Washington; University School of Public Health and Health Services,; Washington, DC 20006, USA. ihojxl@gwumc.edu
- HIV offers a lens through which the underlying problems of the US health care system can be examined. New treatments offer the potential of prolonged quality of life for people living with HIV if they have adequate access to health care. However, increasing numbers of new cases of HIV occur among individuals with poor
- Tracking the HIV epidemic: current issues, future challenges.
- Am J Public Health. 2000 Jul;90(7):1037-41. Unique Identifier : AIDSLINE MED/20355370
- Fleming PL; Wortley PM; Karon JM; DeCock KM; Janssen RS; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.; pfleming@cdc.gov
- The emergence of a new infectious disease, AIDS, in the early 1980s resulted in the development of a national AIDS surveillance system. AIDS surveillance data provided an understanding of transmission risks and characterized communities affected by the epidemic. Later, these data provided the basis for allocating reso
- Culture, sexuality, and women's agency in the prevention of HIV/AIDS in southern Africa.
- Am J Public Health. 2000 Jul;90(7):1042-8. Unique Identifier : AIDSLINE MED/20355371
- Susser I; Stein Z; Anthropology Dept., Hunter College, New York, NY 10021, USA.; isusser@hunter.cuny.edu
- Using an ethnographic approach, the authors explored the awareness among women in southern Africa of the HIV epidemic and the methods they might use to protect themselves from the virus. The research, conducted from 1992 through 1999, focused specifically on heterosexual transmission in 5 sites that were selected to r
- The social geography of AIDS and hepatitis risk: qualitative approaches for assessing local differences in sterile-syringe access among injection drug users.
- Am J Public Health. 2000 Jul;90(7):1049-56. Unique Identifier : AIDSLINE MED/20355372
- Singer M; Stopka T; Siano C; Springer K; Barton G; Khoshnood K; Gorry de Puga A; Heimer R; Hispanic Health Council, Hartford, Conn. 06106, USA.; anthro8566@aol.com
- While significant gains have been achieved in understanding and reducing AIDS and hepatitis risks among injection drug users (IDUs), it is necessary to move beyond individual-level characteristics to gain a fuller understanding of the impact of social context on risk. In this study, 6 qualitative methods were used in
- Perceived unmet need for oral treatment among a national population of HIV-positive medical patients: social and clinical correlates.
- Am J Public Health. 2000 Jul;90(7):1059-63. Unique Identifier : AIDSLINE MED/20355374
- Marcus M; Freed JR; Coulter ID; Der-Martirosian C; Cunningham W; Andersen R; Garcia I; Schneider DA; Maas WR; Bozzette SA; Shapiro MF; School of Dentistry, University of California at Los Angeles,; USA. mamarcus@ucla.edu
- OBJECTIVES: This study examines social, behavioral, and clinical correlates of perceived unmet need for oral health care for people with HIV infection. METHODS: Baseline in-person interviews with 2864 individuals were conducted with the HIV Cost and Services Utilization Study cohort, a nationally representative probab
- Economic deprivation and AIDS incidence in Massachusetts.
- Am J Public Health. 2000 Jul;90(7):1064-73. Unique Identifier : AIDSLINE MED/20355375
- Zierler S; Krieger N; Tang Y; Coady W; Siegfried E; DeMaria A; Auerbach J; Department of Health and Social Behavior, Harvard School of; Public Health, Boston, Mass., USA. sally_zierler@brown.edu
- OBJECTIVES: This study quantified AIDS incidence in Massachusetts in relation to economic deprivation. METHODS: Using 1990 census block-group data, 1990 census population counts, and AIDS surveillance registry data for the years 1988 through 1994, we generated yearly and cumulative AIDS incidence data for the state of
- HIV-infected parents and their children in the United States [see comments]
- Am J Public Health. 2000 Jul;90(7):1074-81. Unique Identifier : AIDSLINE MED/20355376
- Schuster MA; Kanouse DE; Morton SC; Bozzette SA; Miu A; Scott GB; Shapiro MF; RAND, Santa Monica, CA 90210-2138, USA. schuster@rand.org
- OBJECTIVES: This study sought to determine the number, characteristics, and living situations of children of HIV-infected adults. METHODS: Interviews were conducted in 1996 and early 1997 with a nationally representative probability sample of 2864 adults receiving health care for HIV within the contiguous
- Bridging the gap between the science and service of HIV prevention: transferring effective research-based HIV prevention interventions to community AIDS service providers.
- Am J Public Health. 2000 Jul;90(7):1082-8. Unique Identifier : AIDSLINE MED/20355377
- Kelly JA; Somlai AM; DiFranceisco WJ; Otto-Salaj LL; McAuliffe TL; Hackl KL; Heckman TG; Holtgrave DR; Rompa D; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53202, USA. kdemming@mcw.edu
- OBJECTIVES: AIDS service organizations (ASOs) rarely have access to the information needed to implement research-based HIV prevention interventions for their clients. We compared the effectiveness of 3 dissemination strategies for transferring HIV prevention models from the research arena to community providers of HIV
- HIV testing among the general US population and persons at increased risk: information from national surveys, 1987-1996.
- Am J Public Health. 2000 Jul;90(7):1089-95. Unique Identifier : AIDSLINE MED/20355378
- Anderson JE; Carey JW; Taveras S; Behavioral Intervention Research Branch, Centers for Disease; Control and Prevention, Atlanta 30333, USA. jea1@cdc.gov
- OBJECTIVES: We used data from national surveys to measure the rate of HIV testing in the general US population and among persons at increased behavioral risk and summarized what has been learned about HIV testing from these surveys. METHODS: Three nationally representative surveys were used: the National Health Interv
- A participant observation study using actors at 30 publicly funded HIV counseling and testing sites in Pennsylvania.
- Am J Public Health. 2000 Jul;90(7):1096-9. Unique Identifier : AIDSLINE MED/20355379
- Silvestre AJ; Gehl MB; Encandela J; Schelzel G; Graduate School of Public Health, University of Pittsburgh, Pa.,; USA.
- OBJECTIVES: This study was designed to augment an evaluation of Pennsylvania publicly funded HIV counseling and testing sites, particularly of the staff-client interaction. METHODS: Actors were trained as research assistants and sent to 30 randomly chosen sites to be tested and counseled for HIV disease. Instruments b
- HIV transmission and the cost-effectiveness of methadone maintenance.
- Am J Public Health. 2000 Jul;90(7):1100-11. Unique Identifier : AIDSLINE MED/20355380
- Zaric GS; Barnett PG; Brandeau ML; Cooperative Studies Program, Palo Alto Veterans Affairs Health; Care System, Menlo Park, Calif. 94025, USA.
- OBJECTIVES: This study determined the cost-effectiveness of expanding methadone maintenance treatment for heroin addiction, particularly its effect on the HIV epidemic. METHODS: We developed a dynamic epidemic model to study the effects of increased methadone maintenance capacity on health care costs and survival, mea
- Behavioral risk reduction in a declining HIV epidemic: injection drug users in New York City, 1990-1997.
- Am J Public Health. 2000 Jul;90(7):1112-6. Unique Identifier : AIDSLINE MED/20355381
- Des Jarlais C; Perlis T; Friedman SR; Chapman T; Kwok J; Rockwell R; Paone D; Milliken J; Monterroso E; Beth Israel Medical Center, Chemical Dependency Institute, New; York, NY 10003, USA. dcdesjarla@aol.com
- OBJECTIVES: This study assessed trends in HIV risk behaviors among injection drug users in New York City from 1990 to 1997. METHODS: Injection drug users were recruited continuously from a large drug detoxification treatment program (N = 2588) and a research storefront located in a high-drug-use area (N = 2701). Infor
- Frequent use of lubricants for anal sex among men who have sex with men: the HIV prevention potential of a microbicidal gel.
- Am J Public Health. 2000 Jul;90(7):1117-21. Unique Identifier : AIDSLINE MED/20355382
- Carballo-Dieguez A; Stein Z; Saez H; Dolezal C; Nieves-Rosa L; Diaz F; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, NY, USA. ac72@columbia.edu
- OBJECTIVES: This study assessed frequency of rectal lubricant use, opinions about rectal microbicidal gels, and willingness to participate in acceptability trials of rectal microbicides among Latino men who have sex with men (MSM). METHODS: Latino MSM (N = 307) living in New York City were surveyed from October 1995 t
- Preaching to the choir: preference for female-controlled methods of HIV and sexually transmitted disease prevention.
- Am J Public Health. 2000 Jul;90(7):1135-7. Unique Identifier : AIDSLINE MED/20355385
- Murphy ST; Miller LC; Moore J; Clark LF; Annenberg School for Communication, University of Southern; California, Los Angeles 90089-0281, USA. smurphy@usc.edu
- OBJECTIVES: This study assessed interest in female-controlled methods of HIV and sexually transmitted disease (STD) prevention. METHODS: Surveys were conducted with 168 African American women, aged 18 to 32 years, who had had unprotected sex and at least 3 sexual partners in the last 2 years. RESULTS: Of 44 potential
- Delays in seeking HIV care due to competing caregiver responsibilities.
- Am J Public Health. 2000 Jul;90(7):1138-40. Unique Identifier : AIDSLINE MED/20355386
- Stein MD; Crystal S; Cunningham WE; Ananthanarayanan A; Andersen RM; Turner BJ; Zierler S; Morton S; Katz MH; Bozzette SA; Shapiro MF; Schuster MA; Division of General Medicine, Brown University, Providence, RI,; USA. michael_stein@brown.edu
- OBJECTIVES: This study sought to describe the characteristics of HIV-infected persons who delay medical care for themselves because they are caring for others. METHODS: HIV-infected adults (n = 2864) enrolled in the HIV Cost and Services Utilization Study (1996-1997) were interviewed. RESULTS: The odds were 1.6 times
- Scientific silence: AIDS and African Americans in the medical literature [letter]
- Am J Public Health. 2000 Jul;90(7):1145-6. Unique Identifier : AIDSLINE MED/20355388
- Mackenzie S
- Prevention counseling for HIV-negative persons [letter; comment]
- Am J Public Health. 2000 Jul;90(7):1152-3. Unique Identifier : AIDSLINE MED/20355389
- Kamb ML; Peterman TA; Wolitski RJ
- Condom promotion in microbicide trials [letter; comment]
- Am J Public Health. 2000 Jul;90(7):1153-4; discussion 1156. Unique Identifier : AIDSLINE MED/20355390
- van de Wijgert J; Elias C; Ellertson C; McGrory E; Blanchard K; Friedland B; Winikoff B; Brown G
- Condom counseling in microbicide testing: a right of choice [letter; comment]
- Am J Public Health. 2000 Jul;90(7):1154; discussion 1156. Unique Identifier : AIDSLINE MED/20355391
- Pollack AE; Pine RN; Beattie K
- Ethics require the inclusion of condoms and counseling in anti-HIV microbicide trials [letter; comment]
- Am J Public Health. 2000 Jul;90(7):1154-5; discussion 1156. Unique Identifier : AIDSLINE MED/20355392
- Lurie P; Wolfe SM
- Microbicide research and "the investigator's dilemma" [letter; comment]
- Am J Public Health. 2000 Jul;90(7):1155; discussion 1156. Unique Identifier : AIDSLINE MED/20355393
- de Zoysa I; Elias CJ; Bentley ME
- Further thoughts about vaginal microbicide testing [letter; comment]
- Am J Public Health. 2000 Jul;90(7):1155-6. Unique Identifier : AIDSLINE MED/20355394
- Wittkowski KM
- Heterogeneity of Kaposi's sarcoma-associated herpesvirus (HHV-8)-positive effusions [letter; comment]
- Am J Surg Pathol. 2000 Jul;24(7):1036. Unique Identifier : AIDSLINE MED/20352715
- Ascoli V; Sirianni MC; Lo-Coco F
- Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases.
- Ann Intern Med. 2000 Aug 1;133(3):192-6. Unique Identifier : AIDSLINE MED/20365086
- Miller KD; Cameron M; Wood LV; Dalakas MC; Kovacs JA; Warren Grant Magnuson Clinical Center, National Institute of; Allergy and Infectious Diseases Intramural AIDS Program. National; Cancer Institute, National Institutes of Health, Bethesda,; Maryland 20892, USA.
- BACKGROUND: An association between use of zidovudine and didanosine and a rare but life-threatening syndrome of hepatic steatosis, lactic acidosis, and myopathy has been reported. OBJECTIVE: To describe the syndrome of hepatic steatosis, lactic acidosis, and myopathy in four patients taking
- Physician prescribing of sterile injection equipment to prevent HIV infection: time for action.
- Ann Intern Med. 2000 Aug 1;133(3):218-26. Unique Identifier : AIDSLINE MED/20365089
- Burris S; Lurie P; Abrahamson D; Rich JD; Temple University School of Law, Philadelphia, Pennsylvania; 19122, USA. burris@vm.temple.edu
- Injection drug users, their sex partners, and their children are at high risk for acquiring HIV infection and other bloodborne diseases. The risk for disease transmission in the United States is partly the result of restricted access to sterile injection equipment. Physicians and pharm
- [Synthesis of carbamoyl tetrahydro 1,4,2-dioxazines and evaluation of their activity against human immunodeficiency virus]
- Ann Pharm Fr. 2000 May;58(3):180-6. Unique Identifier : AIDSLINE MED/20304409
- El Meslouhi H; Bakri Y; Elhachimi Z; Benjouad A; Essassi EM; Laboratoire de chimie organique heterocyclique, Rabat, Maroc.
- 1,4,2-dioxazine derivatives were synthesized from B-ureidoxyalcools, and their 1H, 13C RMN and mass spectra were determined. Their activity against human immunodeficiency virus and their cytotoxicity were then evaluated. Whereas the derivatives had no effect on virus infectivity nor on reverse transcriptase activity,
- Antiretroviral therapy: state of the HAART.
- Antiviral Res. 2000 Jan;45(1):1-7. Unique Identifier : AIDSLINE MED/20234618
- Vella S; Palmisano L; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
- Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks [published erratum appears in Antiviral Res 2000 Feb;45(2):155-6]
- Antiviral Res. 2000 Jan;45(1):19-32. Unique Identifier : AIDSLINE MED/20234620
- Korba BE; Cote P; Hornbuckle W; Schinazi R; Gerin JL; Tennant BC; Division of Molecular Virology and Immunology, Georgetown; University Medical Center, Rockville, MD, USA.
- Cell culture studies in our laboratory and others have previously demonstrated synergistic antiviral activity for combinations of 3TC (lamivudine) and penciclovir against Hepatitis B Virus (HBV) replication and the Duck Hepatitis B Virus (DHBV). Based
- Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. The ACTG 187 and 199 study teams.
- Antiviral Res. 2000 Jan;45(1):47-58. Unique Identifier : AIDSLINE MED/20234622
- Morse GD; Reichman RC; Fischl MA; Para M; Leedom J; Powderly W; Demeter LM; Resnick L; Bassiakos Y; Timpone J; Cox S; Batts D; Department of Pharmacy, State University of New York at Buffalo,; Amherst 14260, USA.
- RATIONALE: To determine the dosage requirements and pharmacokinetics of atevirdine, a non-nucleoside reverse transcriptase inhibitor and its N-dealkylated metabolite (N-ATV) during phase I studies in patients receiving atevirdine alone or in combination with zidovudine. DESIGN: Two open label, phase I studies conducte
- Effect of protease inhibitors on HIV-1 maturation and infectivity.
- Unique Identifier : AIDSLINE MED/20234623
- Jardine DK; Tyssen DP; Birch CJ
- The effects of HIV-1 protease inhibitors on proteolytic processing and infectivity of virions produced from lymphocytes chronically infected with the virus were studied. Protease inhibition was detected by the accumulation of the polyprotein precursors Pr55gag and P
- Epidemiology of infections with intestinal parasites and human immunodeficiency virus (HIV) among sugar-estate residents in Ethiopia.
- Ann Trop Med Parasitol. 2000 Apr;94(3):269-78. Unique Identifier : AIDSLINE MED/20343286
- Fontanet AL; Sahlu T; Rinke de Wit T; Messele T; Masho W; Woldemichael T; Yeneneh H; Coutinho RA; Ethiopian-Netherlands AIDS Research Project (ENARP), Ethiopian; Health and Nutrition Research Institute (EHNRI), Addis Ababa,; Ethiopia. afontanet@gggd.amsterdam.nl
- Intestinal parasitic infections could play an important role in the progression of infection with human immunodeficiency virus (HIV), by further disturbing the immune system whilst it is already engaged in the fight against HIV. HIV and intestinal parasitic infections were investigated in 1239, randomly selected indiv
- PCR-RFLP analysis of Cryptosporidium parvum isolates from HIV-infected patients in Lisbon, Portugal.
- Ann Trop Med Parasitol. 2000 Apr;94(3):291-7. Unique Identifier : AIDSLINE MED/20343288
- Alves M; Matos O; Spano F; Antunes F; Unidade de Protozoarios Oportunistas/VIH e Outras Protozooses,; Universidade Nova de Lisboa, Portugal. malves@ihmt.unl.pt
- Bioanalysis of syn dimeric HIV-1 protease inhibitor N-benzyl 4-aryl-1,4-dihydropyridine H19: metabolic and cytotoxic properties in Hep G2 cells.
- Arch Pharm (Weinheim). 2000 Jun;333(6):195-7. Unique Identifier : AIDSLINE MED/20366921
- Hilgeroth A; Langner A; Institut fur Pharmazeutische Chemie der; Martin-Luther-Universitat Halle-Wittenberg, Germany.
- Syn dimeric N-benzyl 4-aryl-1,4-dihydropyridine H19 is a nonpeptidic HIV-1 protease inhibitor of the dihydroxyethylene type representing novel C2-symmetric inhibitors. Great interest was focussed on the extent of metabolism of these novel inhibitory structures as their functional groups are similar to certain peptidic
- Autonomic performance and dehydroepiandrosterone sulfate levels in HIV-1-infected individuals: relationship to TH1 and TH2 cytokine profile.
- Arch Neurol. 2000 Jul;57(7):1027-32. Unique Identifier : AIDSLINE MED/20351957
- Schifitto G; McDermott MP; Evans T; Fitzgerald T; Schwimmer J; Demeter L; Kieburtz K; Department of Neurology, University of Rochester, 601 Elmwood; Ave, Box 673, Rochester, NY 14642. gschifitto@mct.rochester.edu.
- BACKGROUND: Products of immune activation, including cytokines and lipid membrane derivatives, have been implicated in the pathogenesis of the neurologic sequelae, including autonomic dysfunction, associated with human immunodeficiency virus 1 (HIV-1) infection. In animal models, autonomic and endocrine dysfunction ar
- Human immunodeficiency virus-associated pure motor lumbosacral polyradiculopathy.
- Arch Neurol. 2000 Jul;57(7):1034-9. Unique Identifier : AIDSLINE MED/20351958
- Benatar MG; Eastman RW; Department of Medicine, Suite KS-406, Beth Israel Deaconess; Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.; mbenatar@caregroup. harvard.edu.
- BACKGROUND: Neuromuscular disease is a common manifestation of human immunodeficiency virus infection and acquired immunodeficiency syndrome, but isolated and severe pathology confined to the motor roots or anterior horn cells are not a recognized clinical entity. OBJECTIVE: To describe the novel clinical presentation
- Characteristics of women in jail and treatment orientations. A review.
- Behav Modif. 2000 Jul;24(3):307-24. Unique Identifier : AIDSLINE MED/20338288
- Haywood TW; Kravitz HM; Goldman LB; Freeman A; Isaac Ray Center, Section on Psychiatry & Law at; Rush-Presbyterian-St. Luke's Medical Center, Chicago, USA.
- Women who have been incarcerated are a high-risk group for criminal recidivism, and criminal justice statistics indicate that females are increasing in numbers more rapidly than the male detainee population. According to data from epidemiologic studies, incarcerated women are often young, single, mothers from ethnic m
- Expression of an active form of recombinant Ty1 reverse transcriptase in Escherichia coli: a fusion protein containing the C-terminal region of the Ty1 integrase linked to the reverse transcriptase-RNase H domain exhibits polymerase and RNase H activities.
- Biochem J. 2000 Jun 1;348 Pt 2:337-42. Unique Identifier : AIDSLINE MED/20277935
- Wilhelm M; Boutabout M; Wilhelm FX; Unite Propre de Recherche 9002 du Centre National de la; Recherche Scientifique, Institut de Biologie Moleculaire et; Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg Cedex,; France. wilhelm@ibmc.u-strasbg.fr
- Replication of the Saccharomyces cerevisiae Ty1 retrotransposon requires a reverse transcriptase capable of synthesizing Ty1 DNA. The first description of an active form of a recombinant Ty1 enzyme with polymerase and RNase H activities is reported here. The Ty1 enzyme was expressed as a hexahistidine-tagged fusion pr
- Enzymic methylation of arginyl residues in -gly-arg-gly- peptides.
- Biochem J. 2000 Jun 15;348 Pt 3:573-8. Unique Identifier : AIDSLINE MED/20300607
- Hyun YL; Lew DB; Park SH; Kim CW; Paik WK; Kim S; Graduate School of Biotechnology, Korea University, 136, 5-ka; Anam-dong, Sungbuk-ku, Seoul, 136-701 Korea.
- N(G)-Methylation of arginine residues in many nucleic-acid-binding proteins are formed post-translationally, catalysed by S-adenosylmethionine:protein-arginine N-methyltransferase in their glycine-rich and arginine-rich motifs. The amino acid sequences of the stimulator of HIV-1 TAR (Tat-responsive element) RNA-bindin
- Interleukin 16: implications for CD4 functions and HIV-1 progression.
- Immunol Today. 2000 Jun;21(6):273-80. Unique Identifier : AIDSLINE MED/20286321
- Center DM; Kornfeld H; Ryan TC; Cruikshank WW; Evans Memorial Department of Medicine, Pulmonary Center at Boston; University School of Medicine, MA 02118, USA.; dcenter@lung.bumc.bu.edu
- In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.
- Is pathogenic humoral autoimmunity a Th1 response? [letter]
- Immunol Today. 2000 Jun;21(6):306-7. Unique Identifier : AIDSLINE MED/20286327
- Saoudi A; Guery JC; De Baets M
- Human immunodeficiency virus disease. Managing respiratory complications through the life span.
- Crit Care Nurs Clin North Am. 1999 Dec;11(4):455-64. Unique Identifier : AIDSLINE MED/20313161
- Jones KM; Department of Critical Care and the Emergency Center, Sinai; Hospital of Baltimore, USA.
- HIV infection is a chronic illness that affects individuals of all ages. The pulmonary system is the most common body system affected by the disease. Management of these complications has improved over the years and has resulted in a decline in mortality. Critical care nurses should understand the complications that d
- Practice guidelines for the treatment of candidiasis. Infectious diseases society of America.
- Clin Infect Dis. 2000 Apr;30(4):662-78. Unique Identifier : AIDSLINE MED/20233749
- Rex JH; Walsh TJ; Sobel JD; Filler SG; Pappas PG; Dismukes WE; Edwards JE; Dept. of Internal Medicine, Center for the Study of Emerging and; Re-emerging Pathogens, University of Texas Medical School,; Houston, TX 77030, USA. jrex@heart.med.uth.tmc.edu
- Infections due to Candida species are the most common of the fungal infections. Candida species produce a broad range of infections, ranging from nonlife-threatening mucocutaneous illnesses to invasive process that may involve virtually any organ. Such a broad range of infections requires an equally broad range of dia
- Practice guidelines for the management of patients with sporotrichosis. For the Mycoses Study Group. Infectious diseases society of America.
- Clin Infect Dis. 2000 Apr;30(4):684-7. Unique Identifier : AIDSLINE MED/20233751
- Kauffman CA; Hajjeh R; Chapman SW; Division of Infectious Diseases, University of Michigan Medical; School and Veterans Affairs Medical Center, Ann Arbor 48105, USA.; ckauff@umich.edu
- The recommendations for the treatment of sporotrichosis were derived primarily from multicenter, nonrandomized treatment trials, small retrospective series, and case reports; no randomized, comparative treatment trials have been reported. Most cases of sporotrichosis are non life-threatening localized infections of th
- Practice guidelines for the management of patients with histoplasmosis. Infectious diseases society of America.
- Clin Infect Dis. 2000 Apr;30(4):688-95. Unique Identifier : AIDSLINE MED/20233752
- Wheat J; Sarosi G; McKinsey D; Hamill R; Bradsher R; Johnson P; Loyd J; Kauffman C; Department of Medicine and Pathology, Indiana University School; of Medicine, Indianapolis 46202, USA. lwheat@iupui.edu
- OBJECTIVE: The objective of this guideline is to provide recommendations for treating patients with the more common forms of histoplasmosis. PARTICIPANTS AND CONSENSUS PROCESS: A working group of 8 experts in this field was convened to develop this guideline. The working group developed and refined the guideline throu
- Practice guidelines for the management of cryptococcal disease. Infectious diseases society of America.
- Clin Infect Dis. 2000 Apr;30(4):710-8. Unique Identifier : AIDSLINE MED/20233754
- Saag MS; Graybill RJ; Larsen RA; Pappas PG; Perfect JR; Powderly WG; Sobel JD; Dismukes WE; University of Alabama at Birmingham, 35294-2050, USA.; msaag@uab.edu For the Mycoses Study Group Cryptococcal; Subproject.
- An 8-person subcommittee of the National Institute of Allergy and Infectious Diseases (NIAID) Mycoses Study Group evaluated available data on the treatment of cryptococcal disease. Opinion regarding optimal treatment was based on personal experience and information in the literature. The relative strength of each reco
- Correlates of human immunodeficiency virus infection risk behavior in male attendees of a clinic for sexually transmitted disease.
- Clin Infect Dis. 2000 Apr;30(4):723-9. Unique Identifier : AIDSLINE MED/20233756
- Jenkins RA; Jenkins PR; Nannis ED; McKee KT Jr; Temoshok LR; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA. rgj2@cdc.gov
- Human immunodeficiency virus (HIV) infection risk behavior was evaluated in a cross-sectional survey of 400 male active-duty US Army personnel who presented at a sexually transmitted disease (STD) clinic with symptoms of acute urethritis. High-risk partners were common, and nearly one-quarter of the sample had previou
- Reducing risk of sexually transmitted disease (STD) and human immunodeficiency virus infection in a military STD clinic: evaluation of a randomized preventive intervention trial.
- Clin Infect Dis. 2000 Apr;30(4):730-5. Unique Identifier : AIDSLINE MED/20233757
- Jenkins PR; Jenkins RA; Nannis ED; McKee KT Jr; Temoshok LR; Care Clinic, Fayetteville, NC 28305-3438, USA.
- Three single-session preventive interventions for reducing sexually transmitted disease (STD) and human immunodeficiency virus infection risk behaviors were evaluated with a sample of 400 men who attended a large military STD clinic. A quasi-experimental, pre-evaluation/postevaluation design was used, comparing standa
- [Ethical aspects of medical practice in AIDS (editorial; comment)]
- An Med Interna. 2000 Apr;17(4):171-3. Unique Identifier : AIDSLINE MED/20352230
- Mones Xiol J; Barrio Medrano JL
- [Changes in the profile of HIV-positive patients. What has happened in the last 5 years? (see comments)]
- An Med Interna. 2000 Apr;17(4):174-7. Unique Identifier : AIDSLINE MED/20352231
- Marco Martinez J; Barba Martin R; Gomez-Rodrigo J; Garcia-Meabe B; Joya D; Cabrera S; Plaza S; Departamento de Medicina Interna y Enfemedades Infecciosas,; Hospital Severo Ochoa, Leganes, Madrid.
- OBJECTIVE: To evaluate possible changes in the social, cultural and economical profile of our HIV infected patients appearing during the last five years and their potential impact on incidence, prevention, and follow-up of HIV infection. METHODS: We conduce a retrospective analysis of demographic, sociocultural, clini
- [Clinico-epidemiologic manifestations of progressive multifocal leukoencephalopathy in patients with acquired immunodeficiency syndrome (AIDS) (see comments)]
- An Med Interna. 2000 Apr;17(4):178-81. Unique Identifier : AIDSLINE MED/20352232
- Iglesias Oliva L; Nan D; Garcia-Palomo JD; Farinas MC; Departamento de Medicina Interna, Hospital Universitario Marques; de Valdecilla, Santander, Cantabria.
- BASIS: Severely immunosuppressed patients, including those with AIDS in advanced stage, can suffer opportunistic infections, between them PML. The purpose of this study is to determine epidemiological, clinical and neuroradiological parameters of HIV infected patients diagnosed of PML. METHOD: Retrospective review of
- [Prognosis of HIV-infection. Let's put ourselves in all the cases (letter; comment)]
- An Med Interna. 2000 Apr;17(4):224-5. Unique Identifier : AIDSLINE MED/20352249
- Martinez Gonzalez J; de Ramon Garrido E; Castano Carrecedo M; Causse Prados M
- Secretion of bioactive interleukin-1beta by dendritic cells is modulated by interaction with antigen specific T cells.
- Blood. 2000 Jun 15;95(12):3809-15. Unique Identifier : AIDSLINE MED/20304482
- Gardella S; Andrei C; Costigliolo S; Olcese L; Zocchi MR; Rubartelli A; National Institute for Cancer Research, Genova, Italy.
- The role of interleukin-1beta (IL-1beta) as a regulator of the immune response, although extensively investigated, is still debated. We then studied the expression of IL-1beta by human dendritic cells (DCs), the professional antigen presenting cells, and its modulation during immune reactions in vitro. Our results sho
- Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
- Blood. 2000 Jun 15;95(12):3816-22. Unique Identifier : AIDSLINE MED/20304483
- Wang LH; Kirken RA; Yang XY; Erwin RA; DaSilva L; Yu CR; Farrar WL; Cytokine Molecular Mechanisms Section, Laboratory of Molecular; Immunoregulation, Division of Basic Sciences, National Cancer; Institute, Frederick, MD 21702, USA.
- Interleukin (IL) 4 is a potent immunomodulatory cytokine secreted by T-helper 2 (Th2) cells and Th2 mast cells that promotes the commitment of cells. However, unregulated production and release of IL-4 can exacerbate allergic reactions and increase susceptibility to infectious organisms and viruses. Here, we present e
- TEL-JAK2 transgenic mice develop T-cell leukemia.
- Blood. 2000 Jun 15;95(12):3891-9. Unique Identifier : AIDSLINE MED/20304493
- Carron C; Cormier F; Janin A; Lacronique V; Giovannini M; Daniel MT; Bernard O; Ghysdael J; Centre National de la Recherche Scientifique (CNRS) UMR; 146-Institut Curie, Centre Universitaire, Orsay, France.
- We previously reported a fusion between TEL and JAK2 in a t(9;12)(p24;p13) chromosomal translocation in childhood acute T-cell leukemia. This fusion gene encodes a TEL-JAK2 chimeric protein in which the 336 amino-terminal residues of TEL, including its specific self-association domain, are fused to the kinase domain o
- Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells.
- Blood. 2000 Jun 15;95(12):3915-21. Unique Identifier : AIDSLINE MED/20304496
- Mori N; Fujii M; Iwai K; Ikeda S; Yamasaki Y; Hata T; Yamada Y; Tanaka Y; Tomonaga M; Yamamoto N; Department of Preventive Medicine and AIDS Research, Institute of; Tropical Medicine, Nagasaki University, Nagasaki, Japan.; n-mori@net.nagasaki-u.ac.jp
- Human T-cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL). This study examined the status of the oncogenic transcription factor AP-1 in leukemic cells freshly isolated from patients with ATL. Leukemic cells from peripheral blood of all patients with ATL exhibited constitutive AP
- p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells.
- Blood. 2000 Jun 15;95(12):3939-44. Unique Identifier : AIDSLINE MED/20304499
- Takemoto S; Trovato R; Cereseto A; Nicot C; Kislyakova T; Casareto L; Waldmann T; Torelli G; Franchini G; Basic Research Laboratory, Division of Basic Sciences, and the; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892, USA.
- Human T-cell lymphotropic virus type I (HTLV-I) transforms T cells in vitro, and the viral transactivator Tax functionally impairs the tumor suppressor p53 protein, which is also stabilized in HTLV-I-infected T cells. Thus, the functional impairment of p53 is essential to maintain the viral-induced proliferation of CD
- CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway.
- Blood. 2000 Jul 1;96(1):195-202. Unique Identifier : AIDSLINE MED/20352001
- Tateyama M; Oyaizu N; McCloskey TW; Than S; Pahwa S; Department of Pediatrics, Division of Allergy/Immunology, North; Shore University Hospital-New York University School of Medicine,; Manhasset, New York 11030, USA.
- CD4 molecules serve as coreceptors for the T-cell receptor (TCR)/CD3 complex that are engaged coordinately with TCR and facilitate antigen-specific T-cell activation leading to interleukin 2 ( IL-2 ) production and proliferation. However, cross-ligation of CD4 molecules
- T-cell progenitor function during progressive human immunodeficiency virus-1 infection and after antiretroviral therapy.
- Blood. 2000 Jul 1;96(1):242-9. Unique Identifier : AIDSLINE MED/20352007
- Clark DR; Repping S; Pakker NG; Prins JM; Notermans DW; Wit FW; Reiss P; Danner SA; Coutinho RA; Lange JM; Miedema F; Department of Clinical Viro-Immunology, Laboratory for; Experimental and Clinical Immunology, CLB, Sanquin Blood Supply; Foundation, the National AIDS Therapy Evaluation Center, the; Division of Infectious Diseases, Amesterdam, The Netherlands.
- Impairment of T-cell renewal has been proposed as contributing to CD4(+) T-cell depletion in persons infected with human immunodeficiency virus-1. We analyzed the T-cell development capacity of progenitors using fetal thymus organ culture. Those who progressed to AIDS had a dramatic loss in T-cell development capacity
- HIV protease inhibitors restore impaired T-cell proliferative response in vivo and in vitro: a viral-suppression-independent mechanism.
- Blood. 2000 Jul 1;96(1):250-8. Unique Identifier : AIDSLINE MED/20352008
- Lu W; Andrieu JM; Laboratory of Molecular Oncology and Virology, Necker Faculty of; Medicine at Laennec Hospital, Rene Descartes (Paris V); University, Paris, France. weilu@intercancer.net
- In 99 adults infected with human immunodeficiency virus type 1 (HIV-1) who received highly active antiretroviral therapy (HAART) (including 2 nucleoside analogues and 1 or 2 protease inhibitors ) for 1 year, CD4(+) and CD8(+) T cells (including memory and naive subse
- Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples.
- Blood. 2000 Jul 1;96(1):275-81. Unique Identifier : AIDSLINE MED/20352012
- Nicot C; Mahieux R; Takemoto S; Franchini G; Basic Research Laboratory Division of Basic Sciences, Laboratory; of Receptor Biology and Gene Expression, National Cancer; Institute, National Institutes of Health, Bethesda, MD 20892,; USA. cbeben@helix.nih.gov
- Human T lymphotropic virus type I (HTLV-I) is the etiological agent of adult T-cell lymphocytic leukemia (ATLL), whereas HTLV-II has not been associated with hematopoietic malignancies. The control of apoptotic pathways has emerged as a critical step in the development of many cancer types. As a result, the underlying
- Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes.
- Blood. 2000 Jul 1;96(1):41-9. Unique Identifier : AIDSLINE MED/20351978
- Sharron M; Pohlmann S; Price K; Lolis E; Tsang M; Kirchhoff F; Doms RW; Lee B; University of Pennsylvania, Department of Pathology and; Laboratory Medicine, Philadelphia, PA 19104, USA.
- CCR5 and CXCR4 are the major coreceptors that mediate human immunodeficiency virus 1 (HIV-1) infection, while most simian immunodeficiency virus (SIV) isolates use CCR5. A number of alternative coreceptors can also mediate infection of some virus strains in vitro, although little is known about their in vivo relevance
- Combined treatment with thymosin-alpha1 and low dose interferon-alpha after dacarbazine in advanced melanoma.
- Melanoma Res. 2000 Apr;10(2):189-92. Unique Identifier : AIDSLINE MED/20260865
- Rasi G; Terzoli E; Izzo F; Pierimarchi P; Ranuzzi M; Sinibaldi-Vallebona P; Tuthill C; Garaci E; Istituto di Medicina Sperimentale, Consiglio Nazionale Ricerche,; Rome, Italy. guidorasi@hotmail.com
- Recent advances: obstetrics.
- BMJ. 2000 Jul 1;321(7252):33-5. Unique Identifier : AIDSLINE MED/20334477
- Roberts JM; Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA; 15213-3054, USA. rsislm@mail.magee.edu
- 'Noise' in microbiological screening assays.
- Transfus Med. 2000 Jun;10(2):97-106. Unique Identifier : AIDSLINE MED/20307446
- Dow BC; Scottish National Blood Transfusion Service Microbiology; Reference Unit, Glasgow & West of Scotland Blood Transfusion; Service at Law Hospital, Carluke, Lanarkshire, UK.
- Why aren't foamy viruses pathogenic?
- Trends Microbiol. 2000 Jun;8(6):284-9. Unique Identifier : AIDSLINE MED/20299326
- Linial M; Divn. of Basic Sciences, Fred Hutchinson Cancer Research Center,; 1100 Fairview Ave N., Seattle WA 98019, USA. mlinial@fhcrc.org
- Foamy viruses are complex retroviruses that lead to either highly cytopathic or persistent infections in vitro, but to non-pathogenic lifelong infections in naturally or accidentally infected hosts. Factors that could contribute to these benign persistent infections include regulated transcription from the two viral p
- Depression and thoughts of suicide among middle-aged and older persons living with HIV-AIDS.
- Psychiatr Serv. 2000 Jul;51(7):903-7. Unique Identifier : AIDSLINE MED/20336917
- Kalichman SC; Heckman T; Kochman A; Sikkema K; Bergholte J; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53226, USA. sethk@mcw.edu
- OBJECTIVE: This study examined the prevalence and characteristics of suicidal ideation among middle-aged and older persons who have HIV infection or AIDS. METHODS: A total of 113 subjects older than age 45 who had HIV-AIDS were recruited from AIDS service organizations in Milwaukee, Wisconsin, and New York City. Parti
- Burkitt's lymphoma: molecular pathogenesis and treatment.
- Cancer Invest. 2000;18(6):574-83. Unique Identifier : AIDSLINE MED/20379395
- Bishop PC; Rao VK; Wilson WH; Division of Clinical Science, National Cancer Institute,; Bethesda, Maryland, USA.
- [The roles for modeling in epidemiology]
- C R Acad Sci III. 2000 May;323(5):429-33. Unique Identifier : AIDSLINE MED/20337453
- Valleron AJ; Unite Inserm U 444, universite Pierre-et-Marie-Curie, CHU; Saint-Antoine, Paris, France. valleron@b3e.jussieu.fr
- Mathematical modelling in epidemiology was pioneered by D. Bernoulli in 1760 in his work demonstrating the effectiveness of the technique of variolation against smallpox. Mathematical epidemiology concerns presently infectious diseases (such as HIV infection, hepatitis C, Prion diseases, influenza, etc.) as well as no
- Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study. Women's Interagency HIV Study.
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Jun;89(6):702-9. Unique Identifier : AIDSLINE MED/20305206
- Mulligan R; Navazesh M; Komaroff E; Greenspan D; Redford M; Alves M; Phelan J; Department of Dental Medicine and Public Health, University of; Southern California, School of Dentistry, Los Angeles 90089-0641,; USA.
- OBJECTIVE: To determine the prevalence of enlargement, tenderness, and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study Design: The study subjects are participants in the Women s Interagency HIV Study (WIHS), a multicenter study
- T-cell subsets (Th1 versus Th2).
- Ann Allergy Asthma Immunol. 2000 Jul;85(1):9-18; quiz 18, 21. Unique Identifier : AIDSLINE MED/20378102
- Romagnani S; Department of Internal Medicine, University of Florence, Firenze,; Italy.
- LEARNING OBJECTIVE: To understand the current status of knowledge in the basic field of polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based on their profile of cytokine production (type 1 or Th1 and type 2 or Th2). DATA SOURCES: Relevant articles and publications from the medical lite
- Efficient gene transfer to hematopoietic progenitor cells using SV40-derived vectors.
- Unique Identifier : AIDSLINE MED/20302350
- Strayer DS; Pomerantz RJ; Yu M; Rosenzweig M; BouHamdan M; Yurasov S; Johnson RP; Goldstein H
- We used recombinant SV40 (rSV40)-derived vectors to deliver transgenes to human and simian hematopoietic progenitor cells in culture, and in vivo after transduction ex vivo. rSV40 are highly efficient vectors that are made in very high titers. They infect almost all cells, whether resting or dividing. Two rSV40s were
- Dietary nucleic acids and Th1/Th2 balance: a clue to cow's milk allergy? [comment] [editorial]
- Clin Exp Allergy. 2000 Jul;30(7):908-11. Unique Identifier : AIDSLINE MED/20307531
- Calder PC
- Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity [see comments]
- Unique Identifier : AIDSLINE MED/20307540
- Sudo N; Aiba Y; Takaki A; Tanaka K; Yu XN; Oyama N; Koga Y; Kubo C; Department of Psychosomatic Medicine, Graduate School of Medical; Sciences, Kyushu University, Fukuoka, Japan.
- BACKGROUND: Dietary sources of nucleic acids and their relative components are known to affect host immune function; however, it has not yet been clarified whether such dietary nucleic acids influence the pathogenesis of allergic reaction. OBJECTIVE: The purpose of this study is to elucidate the effect of dietary nucl
- Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells.
- Cancer Gene Ther. 2000 Feb;7(2):247-54. Unique Identifier : AIDSLINE MED/20231402
- Tasaki K; Yoshida Y; Maeda T; Miyauchi M; Kawamura K; Takenaga K; Yamamoto H; Kouzu T; Asano T; Ochiai T; Sakiyama S; Tagawa M; Department of Surgery (II), Chiba University School of Medicine,; Japan.
- We investigated the antitumor effects induced by the production of interleukin-12 (IL-12) or IL-18, which influence the function of T helper type 1 cells, in murine colon carcinoma cells (Colon 26). Retrovirally transduced cells with IL-12 genes that encoded both p35 and p40 (Colon 26/IL-12) lost their tumorigenicity
- SEREX analysis for tumor antigen identification in a mouse model of adenocarcinoma.
- Cancer Gene Ther. 2000 Mar;7(3):446-55. Unique Identifier : AIDSLINE MED/20227418
- Hampton TA; Conry RM; Khazaeli MB; Shaw DR; Curiel DT; LoBuglio AF; Strong TV; Gene Therapy Center, and Department of Medicine, University of; Alabama at Birmingham, 35294, USA.
- Evaluation of immunotherapy strategies in mouse models of carcinoma is hampered by the limited number of known murine tumor antigens (Ags). Although tumor Ags can be identified based on cytotoxic T-cell activation, this approach is not readily accomplished for many tumor types. We applied an alternative strategy based
- CT of parenchymal and bronchial tuberculosis.
- Eur Radiol. 2000;10(5):699-709. Unique Identifier : AIDSLINE MED/20281124
- Beigelman C; Sellami D; Brauner M; Department of Radiology, Groupe Hospitalier Pitie Salpetriere,; Paris, France.
- Tuberculosis (TB) remains a common disease in the World. Its incidence has risen steadily since 1985, despite a preexisting continuous decreasing of its frequency due to an effective chemotherapy. Nonwhite people, socioeconomically disadvantaged, chronically debilitated groups and AIDS patients are the most concerned.
- Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.
- Emerg Infect Dis. 2000 May-Jun;6(3):265-72. Unique Identifier : AIDSLINE MED/20287800
- Beard CB; Carter JL; Keely SP; Huang L; Pieniazek NJ; Moura IN; Roberts JM; Hightower AW; Bens MS; Freeman AR; Lee S; Stringer JR; Duchin JS; del Rio C; Rimland D; Baughman RP; Levy DA; Dietz VJ; Simon P; Navin TR; Centers for Disease Control and Prevention, Atlanta, Georgia; 30341-3724, USA. cbb0@cdc.gov
- To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were obs
- Spontaneous regression of HIV associated T-cell non-Hodgkin's lymphoma with highly active antiretroviral therapy.
- Eur J Med Res. 2000 Jun 20;5(6):236-40. Unique Identifier : AIDSLINE MED/20343018
- Fatkenheuer G; Hell K; Roers A; Diehl V; Salzberger B; Klinik I fur Innere Medizin, Universitat zu Koln, D-50924; Koln, Germany. G.Faetkenheuer@uni-koeln.de.
- A subcutaneous, T-phenotypic anaplastic large cell lymphoma (CD30/Ki1-positive, EBV positive) was diagnosed in a HIV-infected bisexual man. Without chemotherapy the patient had a sustained long-term remission of this tumor (more than three years) after the initiation of highly active antiretroviral therapy. By PCR ana
- Addison-disease - an unusual clinical manifestation of CMV-end organ disease in pediatric AIDS.
- Eur J Med Res. 2000 Jun 20;5(6):247-50. Unique Identifier : AIDSLINE MED/20343020
- Seel K; Guschmann M; van Landeghem F; Grosch-Worner I; Charite, Universitatsklinikum der Humboldt Universitat zu; Berlin, Germany. karen.seel@charite.de.
- CMV infection is common in pediatric HIV-1 infected patients. We present a case report, to our knowledge the first pediatric patient, in which Addison-disease due to CMV was suspected during lifetime. We want to point out the importance of routine clinical and l
- Glycyl-glutamine improves in vitro lymphocyte proliferation in AIDS patients.
- Eur J Med Res. 2000 Jun 20;5(6):263-7. Unique Identifier : AIDSLINE MED/20343022
- Kohler H; Ruggeberg J; Langer K; Jablonowski H; Adam R; Wahn V; Schroten H; Department of Pediatrics, Heinrich-Heine Universitat, Moorenstr.; 5, D-40225 Dusseldorf, Germany.
- BACKGROUND: Glutamine (Gln) is a major nutrient for rapidly proliferating cells. Unlike glutamine itself, the dipeptide glycyl-glutamine as a source for Gln is stable in aqueous solutions ex vivo. In order to evaluate the possible therapeutic role of glycyl-glutamine on lymphocyte proliferation we investigated its inf
- A novel RNA motif that binds efficiently and specifically to the Ttat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo.
- Genes Cells. 2000 May;5(5):371-88. Unique Identifier : AIDSLINE MED/20345606
- Yamamoto R; Katahira M; Nishikawa S; Baba T; Taira K; Kumar PK; National Institute of Bioscience and Human Technology, University; of Tsukuba, Japan.
- BACKGROUND: To find a novel RNA that would bind efficiently and specifically to Tat protein but not to other cellular factors, we used an in vitro selection method and isolated a novel aptamer RNATat, a 37-mer RNA oligomer, that binds efficiently to the Tat protein of HIV-1. In the present study, we analysed various p
- Molecular beacon aptamer fluoresces in the presence of Tat protein of HIV-1.
- Genes Cells. 2000 May;5(5):389-96. Unique Identifier : AIDSLINE MED/20345607
- Yamamoto R; Kumar PK; National Institute of Bioscience and Human Technology, University; of Tsukuba, Tsukuba 305-8572, Japan.
- BACKGROUND: We reported an aptamer, RNATat that binds to the Tat protein of HIV with two orders of magnitude greater (133-fold) affinity over the TAR RNA of HIV-1 and specifically inhibits the Tat-dependent trans-activation of transcription, both in vitro and in vivo (demonstrated in the accompanying article, Yamamoto
- Immunogenicity comparison of a multi-antigenic peptide bearing V3 sequences of the human immunodeficiency virus type 1 with TAB9 protein in mice.
- J Pept Sci. 2000 May;6(5):217-24. Unique Identifier : AIDSLINE MED/20280996
- Cruz LJ; Quintana D; Iglesias E; Garcia Y; Huerta V; Garay HE; Duarte C; Reyes O; Division de Quimica-Fisica, Centro de Ingenieria Genetica y; Biotecnologia, Cubanacan, Habana, Cuba. ljcruz@cigb.edu.cu
- The multiple antigenic peptide system (MAP) has been proposed as a novel and valuable approach for eliciting antibodies for peptides and developing synthetic vaccines. Multi-epitope polypeptides (MEP) have also been developed as an alternative to the recombinant approach for vaccines. The V3 loop from the HIV type 1 (
- Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis.
- Amyloid. 2000 Jun;7(2):126-32. Unique Identifier : AIDSLINE MED/20301533
- Raje N; Kica G; Chauhan D; Zhang Y; Teoh G; Treon SP; Hideshima T; Deng JH; Gao SJ; Alsina M; Wally J; Davies FE; Tai YT; Pinkus GS; Pinkus JL; Skinner M; Comenzo RL; Anderson KC; Department of Adult Oncology, Dana-Farber Cancer Institute,; Boston, MA 02215, USA.
- Primary amyloidosis (AL), like multiple myeloma (MM), results from a clonal proliferation of plasma cells. Recent detection of Kaposi s sarcoma-associated herpesvirus (KSHV) gene sequences in MM patients, although controversial, suggested that KSHV may also be present in AL. In the present study, we assayed for KSHV g
- Cutaneous side effects induced by indinavir.
- Eur J Dermatol. 2000 Jun;10(4):292-6. Unique Identifier : AIDSLINE MED/20307977
- Calista D; Boschini A; Dermatology Unit "M. Bufalini" Hospital, 47023 Cesena, Italy.
- HIV- protease inhibitors demonstrated such high efficacy in short-term studies that they have been approved by the FDA , even though possible toxicity still needs further investigation. In the period between January 1997 and August 19
- Inducible expression of filaggrin increases keratinocyte susceptibility to apoptotic cell death.
- Cell Death Differ. 2000 Jun;7(6):566-73. Unique Identifier : AIDSLINE MED/20284029
- Kuechle MK; Presland RB; Lewis SP; Fleckman P; Dale BA; Department of Oral Biology, University of Washington, Seattle,; Washington, WA 98195, USA. kuechles@u.washington.edu
- Filaggrin is an intermediate filament associated protein that aids the packing of keratin filaments during terminal differentiation of keratinocytes. Premature aggregation of keratin filaments is prevented by filaggrin expression as the inactive precursor, profilaggrin, which is localized in keratohyalin granules in v
- Using all opportunities for improving mental health--examples from South Africa.
- Bull World Health Organ. 2000;78(4):508-10. Unique Identifier : AIDSLINE MED/20343589
- Freeman M; Mental Health and Substance Abuse, Department of Health,; Pretoria, South Africa.
- Characterization of gammadelta T cells expressing CD158b, a killer cell inhibitory receptor, in a patient with chronic CD4(+) lymphocytopenia and disseminated Mycobacterium intracellulare infection.
- Clin Immunol. 2000 Jul;96(1):67-75. Unique Identifier : AIDSLINE MED/20334935
- Airo P; Caruso A; Stellini R; Antonioli C; Malacarne F; Licenziati S; Albertini A; Cattaneo R; Imberti L; Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy.
- A population of Vdelta1(+)Vgamma9(-) gammadelta T cells that represented almost the totality (84%) of circulating lymphocytes in a patient with chronic, non-HIV-related, CD4 lymphocytopenia complicated by a disseminated Mycobacterium intracellulare infection was characterized. These gammadelta(+) T cells expressed a s
- Changes in the Th1 or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA): a kinetic study of the Th subsets in one unusual RA patient.
- Rheumatology (Oxford). 2000 May;39(5):513-22. Unique Identifier : AIDSLINE MED/20313055
- Aarvak T; Chabaud M; Thoen J; Miossec P; Natvig JB; Institute of Immunology, Laboratory for Rheumatology Research,; and the Center for Rheumatic Diseases, The National Hospital,; Oslo, Norway.
- OBJECTIVE: To perform a kinetic study of the Th1/Th2 balance in the rheumatoid arthritis (RA) synovium. METHODS: Three different synovial tissue (ST) samples were obtained from one patient with erosive RA. The characterization of Th1 and Th2 responses was performed by interferon-gamma and interleukin-4 measurements an
- T cell lines specific for a synthetic Heymann nephritis peptide derived from the receptor-associated protein.
- Unique Identifier : AIDSLINE MED/20345494
- Wu H; Zhang GY; Knight JF
- Pathogenic antigens involved in the induction of Heymann nephritis (HN), an experimental rat model of human membranous nephritis, have been identified in megalin (gp330) and the receptor-associated protein (RAP) [1,2]. A pathogenic epitope has been identified in RAP (amino acid 1-86) that plays a significant
- Exogenous type-1 cytokines modulate mercury-induced hyper-IgE in the rat.
- Clin Exp Immunol. 2000 Jul;121(1):17-22. Unique Identifier : AIDSLINE MED/20345474
- Gorrie MJ; Qasim FJ; Whittle CJ; Gillespie KM; Szeto CC; Nicoletti F; Bolton EM; Bradley JA; Mathieson PW; Department of Renal Medicine, Western Infirmary, Glasgow,; Department of Medicine, University of Cambridge, Cambridge and; Academic Renal Unit, University of Bristol, Bristol, UK.
- Suppression of IgE responses is a major goal for immunotherapy, especially in the field of allergy. The Th2 subset of helper T cells plays a vital role in class switching of B cells to IgE production by releasing IL-4. In susceptible rat strains, mercuric chloride (HgCl2) induces activation of Th2 cells, with enhanced
- Characterization of mercuric mercury (Hg2+)-induced lymphoblasts from patients with mercury allergy and from healthy subjects.
- Clin Exp Immunol. 2000 Jul;121(1):23-30. Unique Identifier : AIDSLINE MED/20345475
- Cederbrant K; Hultman P; Department of Health and Environment, Division of Molecular and; Immunological Pathology, Linkoping University, Linkoping,; Sweden. Karin.Cederbrant@astrazeneca.com
- Hg2+ induces lymphocyte proliferation when added to cell cultures from both healthy and mercury-allergic subjects. Consequently, when measuring DNA synthesis a possible Hg2+-specific response, resulting from proliferating memory cells, cannot be discriminated from a non-allergic response. The mechanism behind this non
- Differences in regulatory pathways identify subgroups of T cell-derived Th2 cytokines.
- Clin Exp Immunol. 2000 Jul;121(1):86-93. Unique Identifier : AIDSLINE MED/20345483
- Rafiq K; Bullens DM; Kasran A; Lorre K; Ceuppens JL; Van Gool SW; Laboratory of Experimental Immunology and Division of; Paediatrics, Catholic University of Leuven, Leuven, Belgium.
- We analysed regulatory mechanisms involved in the production of Th2 cytokines by freshly isolated human T cells. We used an in vitro culture system in which the primary signal was provided by a cross-linking anti-CD3 MoAb presented on the Fc receptors of P815 cells. Both CD80 and CD86, expressed on transfected P815 ce
- [A patient with marked immunodeficiency in an HTLV-I carrier: a case report]
- Rinsho Shinkeigaku. 2000 Feb;40(2):135-9. Unique Identifier : AIDSLINE MED/20295640
- Iroi A; Miyashita N; Nakamura S; Ohizumi H; Mizuno Y; Department of Neurology, Juntendo University, School of Medicine.
- We report a 49-year-old man who was an HTLV-I carrier with an immunodeficiency state and intracranial pyramidal tract lesion revealed by MRI. He was born in Hokkaido and was admitted to our hospital because of fluminant hepatitis. On admission, neurologic examination revealed exaggerated deep tendon reflexes including
- [A case of HIV encephalopathy with dementia which showed significant improvement after the combination antiretroviral therapy]
- Rinsho Shinkeigaku. 2000 Feb;40(2):178-80. Unique Identifier : AIDSLINE MED/20295649
- Mizoi Y; Takagi M; Hoshino H; Matsuoka S; Adachi T; Department of Neurology, Tokyo Saiseikai Central Hospital, Japan.
- We report a 63-year-old male with HIV encephalopathy, whose initial symptom was acutely progressing dementia . He tested positive for HIV antibody, and HIV-RNA count was 2.8 x 10(5) copy/ml. All opportunistic infections that could cause dementia were ruled out. Dementia remarkably i
- [Toxoplasmosis versus primary central nervous system lymphoma in AIDS (letter)]
- Rinsho Shinkeigaku. 2000 Feb;40(2):187; discussion 188-9. Unique Identifier : AIDSLINE MED/20295652
- Kishida S
- Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence.
- J Biomol Screen. 2000 Jun;5(3):169-76. Unique Identifier : AIDSLINE MED/20353708
- McMahon JB; Beutler JA; O'Keefe BR; Goodrum CB; Myers MA; Boyd MR; Laboratory of Drug Discovery Research and Development,; Developmental Therapeutics Program, Division of Cancer Treatment; and Diagnosis, National Cancer Institute-Frederick Cancer; Research and Development Center, Frederick, MD 21702-1201, USA.
- The unique, high-affinity binding of cyanovirin-N (CV-N), a potent anti-human immunodeficiency virus (HIV) protein, to the HIV envelope glycoprotein gp120, was exploited to develop an HTS assay in an attempt to discover small-molecule mimetics of CV-N. A competition binding assay was developed using CV-N labeled with
- Cystoid macular edema in a patient with acquired immunodeficiency syndrome and past ocular history of cytomegalovirus retinitis after initiation of protease inhibitors.
- Doc Ophthalmol. 1999;97(3-4):311-5. Unique Identifier : AIDSLINE MED/20353240
- Zafirakis P; Markomichelakis NN; Voudouri A; Theodossiadis GP; Theodossiadis PG; Department of Ophthalmology, School of Medicine, Athens, Greece.
- PURPOSE: To describe a patient with acquired immunodeficiency syndrome (AIDS) who presented with cystoid macular edema (CME) which was not associated with active cytomegalovirus ( CMV ) retinitis or AIDS-related microvasculopat
- Role of macrophage activation in the pathogenesis of Alzheimer's disease and human immunodeficiency virus type 1-associated dementia [see comments]
- Eur J Clin Invest. 2000 Jun;30(6):526-35. Unique Identifier : AIDSLINE MED/20307640
- Smits HA; Boven LA; Pereira CF; Verhoef J; Nottet HS; University Medical Cluster Utrecht, The Netherlands.
- The structure and function of neurons are changed not only during development of the central nervous system but also in certain neurological disorders, such as Alzheimer s disease and human immunodeficiency virus type 1 (HIV-1) -associated dementia . Immunological activation and alt
- Allergen-derived long peptide immunotherapy down-regulates specific IgE response and protects from anaphylaxis.
- Unique Identifier : AIDSLINE MED/20354865
- von Garnier C; Astori M; Kettner A; Dufour N; Heusser C; Corradin G; Spertini F
- To evaluate a long peptide-based allergy vaccine in a murine model, CBA/J mice were sensitized with low dose alum-adsorbed phospholipase A2 (PLA2), a major bee venom allergen. Presensitized mice were treated by daily i.p. injections of a mixture of three long overlapping peptides (44- to 60-mer) spanning the entire PL
- A subpopulation of CD8+ T cells specific for melanocyte differentiation antigens expresses killer inhibitory receptors (KIR) in healthy donors: evidence for a role of KIR in the control of peripheral tolerance.
- Eur J Immunol. 2000 Jun;30(6):1665-75. Unique Identifier : AIDSLINE MED/20354868
- Huard B; Karlsson L; The R.W. Johnson Pharmaceutical Research Institute, San Diego,; USA. huard@cmu.unige.ch
- In cancer patients, NK cell inhibitory receptors (IR) are expressed on a fraction of melanoma-specific lymphocytes with a unique reactivity for tumor antigens derived from normal, nonmutated genes (differentiation antigens). It is presently not known whether expression of these receptors is induced during an immune re
- Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides.
- Eur J Immunol. 2000 Jun;30(6):1676-82. Unique Identifier : AIDSLINE MED/20354869
- Kern F; Faulhaber N; Frommel C; Khatamzas E; Prosch S; Schonemann C; Kretzschmar I; Volkmer-Engert R; Volk HD; Reinke P; Institut fur Medizinische Immunologie, Charite, Berlin,; Germany. florian.kern@charite.de
- The frequencies of human cytomegalovirus (HCMV) protein-specific CD8 T cells, identified by the presence of intracellular IFN-gamma, were measured by flow cytometry following stimulation of freshly isolated peripheral blood mononuclear cells (PBMC) with comprehensive peptide pools.
- IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway.
- Eur J Immunol. 2000 Jun;30(6):1683-90. Unique Identifier : AIDSLINE MED/20354870
- Joss A; Akdis M; Faith A; Blaser K; Akdis CA; Swiss Institute of Allergy and Asthma Research, Davos.
- IL-10 induces T cell anergy in numerous mouse models and specific immunotherapy of allergy in humans. Here, we demonstrate that IL-10 directly acts on T cells which are stimulated via CD28 by efficiently blocking proliferation and cytokine production. T cells tolerized by IL-10 showed high viability and the unresponsi
- Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression.
- Eur J Immunol. 2000 Jun;30(6):1691-7. Unique Identifier : AIDSLINE GENBANK/AL023657
- Gilmour KC; Cranston T; Jones A; Davies EG; Goldblatt D; Thrasher A; Kinnon C; Nichols KE; Gaspar HB; Department of Immunology, Great Ormond Street Hospital NHS Trust,; London, GB.
- X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency in which affected boys show abnormal responses to Epstein-Barr virus infection. The gene defective in XLP has been identified and designated SH2D1A and encodes a protein termed SLAM-associated protein (SAP). Mutation analysis in individuals wi
- Search for agents causing atypical pneumonia in HIV-positive patients by inhibitor-controlled PCR assays.
- Eur Respir J. 1999 Jan;13(1):175-9. Unique Identifier : AIDSLINE MED/20294333
- Tarp B; Jensen JS; Ostergaard L; Andersen PL; Dept of Infectious Diseases, Aarhus University Hospital, Denmark.
- Pneumonia is one of the most frequent complications in acquired immunodeficiency syndrome-patients with Pneumocystis carinii as the leading cause. The true prevalence of atypical agents such as Chlamydia pneumoniae, C. trachomatis, Legionella pneumophila and Mycoplasma pneumoniae in this population of patients is unkn
- The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression.
- FEBS Lett. 2000 Jul 14;477(1-2):123-8. Unique Identifier : AIDSLINE MED/20359303
- Blanco J; Valenzuela A; Herrera C; Lluis C; Hovanessian AG; Franco R; Unite de Virologie et dImmunologie Cellulaire, ERS 572 CNRS,; Institut Pasteur, 28 rue Dr. Roux, 75724 Paris Cedex 15, France.; jblanco@ns.hugtip.scs.es
- HIV-1 external envelope glycoprotein gp120 inhibits adenosine deaminase (ADA) binding to its cell surface receptor in lymphocytes, CD26, by a mechanism that does not require the gp120-CD4 interaction. To further characterize this mechanism, we studied ADA binding to murine clones stably expressing human CD26 and/or hu
- The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence.
- FEBS Lett. 2000 Jul 14;477(1-2):145-9. Unique Identifier : AIDSLINE MED/20359307
- Suarez T; Nir S; Go?i FM; Saez-Cirion A; Nieva JL; Unidad de Biofisica, Departamento de Bioquimica, Universidaad del; Pais Vasco, Aptdo, 644, 48080, Bilboa, Spain.
- We have investigated membrane interactions and perturbations induced by NH(2)-DKWASLWNWFNITNWLWYIK-COOH (HIV(c)), representing the membrane interface-partitioning region that precedes the transmembrane anchor of the human immunodeficiency virus type-1 gp41 fusion protein. The HIV(c) peptide bound with high affinity to
- Cytopathic effect of in situ gene therapy in prostate cancer.
- Hum Pathol. 2000 Jul;31(7):866-70. Unique Identifier : AIDSLINE MED/20378448
- Ayala G; Wheeler TM; Shalev M; Thompson TC; Miles B; Aguilar-Cordova E; Chakraborty S; Kadmon D; Department of Pathology, Center for Cell and Gene Therapy, Baylor; College of Medicine, Houston, TX 77030, USA.
- This is a morphologic study of in situ gene therapy effects in patients with prostate cancer using the Herpes Simplex VirusThymidine Kinase gene (HSV-tk) followed by ganciclovir. Prostatectomy specimens from the first 4 patients showed the following morphologic changes: (1) various degrees of necrosis were seen in can
- Prostaglandin E2 is variably induced by bacterial superantigens in bovine mononuclear cells and has a regulatory role for the T cell proliferative response.
- Immunobiology. 2000 Apr;201(5):493-505. Unique Identifier : AIDSLINE MED/20292142
- Hendricks A; Leibold W; Kaever V; Schuberth HJ; Immunology Unit, School of Veterinary Medicine, Hannover,; Germany.
- Signal transduction in antigen presenting cells via MHC class II molecules induces production of prostaglandin E2 (PGE2) known to possess immunoregulatory potential. Since Staphylococcus aureus superantigens (SAgs) utilize MHC class II molecules as primary ligands, we wanted to know whether PGE2 is induced after in vi
- Detection of CD45iota mRNA in murine Th1 but not Th2 clones.
- Immunobiology. 2000 Apr;201(5):506-14. Unique Identifier : AIDSLINE MED/20292143
- Tsujikawa K; Uchino Y; Ichijo T; Furukawa T; Yamamoto H; Department of Immunology, Graduate School of Pharmaceutical; Sciences, Osaka University, Suita, Japan.; tujikawa@phs.osaka-u.ac.jp
- CD45, a prototype of the receptor-like protein tyrosine phosphatase (PTPase) family, is one of the essential molecules in signal transduction through T cell receptors. Because at least 8 types of CD45 isoforms can potentially be produced by alternative mRNA splicing of exons 4, 5, and 6, the analyses at the transcript
- Regulation of T cell cytokine production by dendritic cells.
- Immunol Cell Biol. 2000 Jun;78(3):214-23. Unique Identifier : AIDSLINE MED/20307718
- Kronin V; Hochrein H; Shortman K; Kelso A; The Walter and Eliza Hall Institute of Medical Research,; Melbourne, Victoria and The Queensland Institute of Medical; Research, Brisbane, Queensland, Australia.
- Previous work has established that the dendritic cells (DC) of mouse spleen regulate the IL-2 production, and hence the extent of proliferation, of the CD8 T cells they activate. It is now reported here that interaction of primary CD8 T cells with splenic CD8alpha- DC
- Pneumocystis carnii pneumonia in AIDS--an autopsy report.
- Indian J Pathol Microbiol. 1999 Jul;42(3):379-82. Unique Identifier : AIDSLINE MED/20319658
- Lanjewar DN; Nambiar A; Anand M; Jain PP; Department of Pathology, Grant Medical College, Mumbai.
- Pneumocystis carinii pneumonia (PCP), the most common presenting manifestation in patients with AIDS from western countries, holds the distinction for being the first opportunistic infection that was associated with AIDS. There is marked paucity of clinically diagnosed and pathologically confirmed cases of PCP in
- Tooth extraction in HIV sero-positive patients.
- Int Dent J. 1999 Dec;49(6):317-21. Unique Identifier : AIDSLINE MED/20364872
- Diz Dios P; Fernandez Feijoo J; Vazquez Garcia E
- Tooth extraction is the dental treatment most commonly carried out among HIV positive patients. In this paper we propose a simple protocol for dental extractions in patients of this type, based on a review of the literature and on our own experience in this field. The factors to be considered when planning a dental ex
- University students' knowledge of AIDS.
- Int J Nurs Stud. 2000 Oct;37(5):423-33. Unique Identifier : AIDSLINE MED/20249145
- Petro-Nustas W; The Hashemite University, PO Box 13133, Zarqa, Jordan.; wasipn@hu.edu.jo
- In this paper, a cross-sectional exploratory design is utilized for the purpose of assessing the knowledge level of HIV/AIDS infection among a convenient sample of university students. The sample consisted of 1013 students at the Bachelor s level across the university faculties (Scientific, Medical and Humanities). Ch
- Coupling ribose selection to fidelity of DNA synthesis. The role of Tyr-115 of human immunodeficiency virus type 1 reverse transcriptase.
- J Biol Chem. 2000 Jun 30;275(26):19759-67. Unique Identifier : AIDSLINE MED/20347883
- Cases-Gonzalez CE; Gutierrez-Rivas M; Menendez-Arias L; Centro de Biologia Molecular "Severo Ochoa," Consejo Superior de; Investigaciones Cientificas-Universidad Autonoma de Madrid,; Cantoblanco, 28049 Madrid, Spain.
- The catalytic efficiency of incorporation of deoxyribonucleotides by wild-type human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) was around 100-fold higher than for dideoxyribonucleotides, in Mg(2+)-catalyzed reactions, and more than 10,000-fold higher than for nucleotides having a 2 -hydroxyl gro
- Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia.
- J Biol Chem. 2000 Jun 30;275(26):19877-82. Unique Identifier : AIDSLINE MED/20347898
- Caffrey M; Braddock DT; Louis JM; Abu-Asab MA; Kingma D; Liotta L; Tsokos M; Tresser N; Pannell LK; Watts N; Steven AC; Simon MN; Stahl SJ; Wingfield PT; Clore GM; Laboratory of Chemical Physics, NIDDK, National Institutes of; Health, Bethesda, Maryland 20892-0510, USA.
- In human immunodeficiency virus (HIV)-infected individuals, the level of the HIV envelope protein gp41 in brain tissue is correlated with neurological damage and dementia . In this paper we show by biochemical methods and electron microscopy that the extracellular ectodomain of puri
- Rectal bleeding, abdominal pain, and fever.
- Hosp Pract (Off Ed). 2000 Jul 15;35(7):21-3. Unique Identifier : AIDSLINE MED/20373214
- Przytulski BS; Lotfi M; Hood C; Adelman HM; University of Freiburg, Germany.
- Stability in the HIV vDNA pool in peripheral CD4+ T cells of untreated patients by single tube quantitative PCR.
- J Virol Methods. 2000 Jun;87(1-2):1-12. Unique Identifier : AIDSLINE MED/20316095
- Hockett RD Jr; Saag MS; Kilby JM; Sfakianos G; Wakefield TB; Bucy RP; Department of Pathology, University of Alabama at Birmingham,; 35233-7331, USA.
- HIV infection leads to loss of CD4 T cells and development of AIDS in most individuals without treatment. While disease progression during HIV infection correlates with the plasma viral load, much less is known about the levels of HIV vDNA. This paper describes the development and validation of a sensitive, quantitati
- A non-radioisotopic quantitative competitive polymerase chain reaction method: application in measurement of human herpesvirus 7 load.
- J Virol Methods. 2000 Jun;87(1-2):177-81. Unique Identifier : AIDSLINE MED/20316113
- Kidd IM; Clark DA; Emery VC; Department of Virology, Royal Free and University College Medical; School, London, UK.
- Quantitative-competitive polymerase chain reaction (QCPCR) is a well-optimised and objective methodology for the determination of viral load in clinical specimens. A major advantage of QCPCR is the ability to control for the differential modulation of the PCR process in the presence of potentially inhibitory material.
- A gag gene heteroduplex mobility assay for subtyping HIV-1.
- J Virol Methods. 2000 Jun;87(1-2):41-51. Unique Identifier : AIDSLINE MED/20316099
- Tatt ID; Barlow KL; Clewley JP; Hepatitis and Retrovirus Laboratory, Central Public Health; Laboratory, London, United Kingdom.
- A heteroduplex mobility assay (HMA) using 753 and 446 base pair (bp) amplicons of the p17/p24 region of the gag gene of HIV-1 has been developed and validated with reference clones and clinical samples representative of subtypes A, B, C, D, E, G, and H. There was complete concordance between the gag HMA assigned subty
- Ultrasensitive in-house reverse transcription-competitive PCR for quantitation of HIV-1 RNA in plasma.
- J Virol Methods. 2000 Jun;87(1-2):91-7. Unique Identifier : AIDSLINE MED/20316104
- Venturi G; Ferruzzi R; Romano L; Catucci M; Valensin PE; Zazzi M; Sezione di Microbiologia, Dipartimento di Biologia Molecolare,; Universita di Siena, Siena, Italy.
- An ultrasensitive version of an in-house reverse transcription-competitive polymerase chain reaction assay described previously for quantitation of human immunodeficiency virus type 1 (HIV-1) RNA in plasma was developed. The increase in sensitivity from 400 to 50 HIV-1 RNA copies/ml was achieved by pelleting virus p
- Pharmacokinetics of a novel testosterone matrix transdermal system in healthy, premenopausal women and women infected with the human immunodeficiency virus.
- J Clin Endocrinol Metab. 2000 Jul;85(7):2395-401. Unique Identifier : AIDSLINE MED/20358590
- Javanbakht M; Singh AB; Mazer NA; Beall G; Sinha-Hikim I; Shen R; Bhasin S; Division of Endocrinology, Metabolism, and Molecular Medicine,; Charles R Drew University of Medicine and Science, Los Angeles,; California 90059, USA.
- The clinical consequences of androgen deficiency in human immunodeficiency virus (HIV)-infected women remain underappreciated. The pharmacokinetics of transdermally administered testosterone in premenopausal women and HIV-infected women have not been studied. In this study we compared the pharmacokinetics of a novel t
- Mammary infection with Staphylococcus aureus in cows: progress from inoculation to chronic infection and its detection.
- J Dairy Res. 2000 May;67(2):155-69. Unique Identifier : AIDSLINE MED/20299708
- Shoshani E; Leitner G; Hanochi B; Saran A; Shpigel NY; Berman A; Faculty of Agriculture, Hebrew University, Rehovot, Israel.
- The progress of Staphylococcus aureus infection from inoculation to the early chronic stage was examined in 12 Israeli-Holstein cows (four primiparous and eight multiparous) for up to 48 d after inoculation. Before inoculation, the primiparous cows were free from any infection and the multiparous cows were infected by
- Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity [see comments]
- J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):124-34. Unique Identifier : AIDSLINE MED/20347064
- Tighe H; Takabayashi K; Schwartz D; Van Nest G; Tuck S; Eiden JJ; Kagey-Sobotka A; Creticos PS; Lichtenstein LM; Spiegelberg HL; Raz E; Department of Medicine and The Sam and Rose Stein Institute for; Research on Aging, and the Department of Pediatrics, University; of California San Diego School of Medicine, La Jolla, CA, USA.
- BACKGROUND: Allergen immunotherapy is inconvenient and associated with the risk of anaphylaxis. Efforts to improve the safety of immunotherapy by means of chemical modification of allergens have not been successful because it greatly reduced their antigenicity. Recently, immunostimulatory DNA sequences (ISS or CpG mot
- Gee whiz: CpG DNA allergy therapy! [editorial; comment]
- J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):37-40. Unique Identifier : AIDSLINE MED/20347051
- Askenase PW
- PBMCs from both atopic asthmatic and nonatopic children show a TH2 cytokine response to house dust mite allergen.
- J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):84-91. Unique Identifier : AIDSLINE MED/20347059
- Nurse B; Puterman AS; Haus M; Berman D; Weinberg EG; Potter PC; Allergology Unit, Department of Immunology, Groote Schuur; Hospital and University of Cape Town, South Africa.
- BACKGROUND: The hypothesis that in atopic diseases the T-helper response is skewed toward a T(H)2-type cytokine response was based on studies with mitogen stimulation, T-cell clones, or both. OBJECTIVE: Using primary cultures, we investigated (1) whether atopic asthmatic patients have a T(H)2 response and nonatopic su
- Natural killer 1.1(+) T cells and "natural suppressor" T cells in the bone marrow.
- J Allergy Clin Immunol. 2000 Jul;106(1 Pt 2):S113-4. Unique Identifier : AIDSLINE MED/20347093
- Strober S; Department of Medicine, Division of Immunology and Rheumatology,; Stanford University School of Medicine, Stanford, CA, USA.; sstrober@stanford.edu
- Unusual cells in the bone marrow of mice and/or humans suppress immune responses and inhibit the mixed leukocyte reaction, graft-versus-host disease, and systemic autoimmunity. Previous studies showed that these natural suppressor T cells expressed the CD4(-)CD8(-) T-cell receptor-alphabeta(+) phenotype. More recent
- The fas antigen is involved in thymic T-cell development as a costimulatory molecule, but not in the deletion of neglected thymocytes.
- J Allergy Clin Immunol. 2000 Jul;106(1 Pt 2):S19-31. Unique Identifier : AIDSLINE MED/20347079
- Kurasawa K; Hashimoto Y; Kasai M; Iwamoto I; Department of Internal Medicine II, Chiba University School of; Medicine, Tokyo, Japan.
- To determine whether the Fas antigen (Fas) is involved in thymic T-cell development, we introduced the lymphoproliferation (lpr) mutation into a T-cell receptor-alphabeta transgenic mouse (DO10 mouse) and generated 4 genotypes of T-cell receptor transgenic mice homozygous or heterozygous for the lpr mutation with sele
- Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation.
- J Allergy Clin Immunol. 2000 Jul;106(1 Pt 2):S45-50. Unique Identifier : AIDSLINE MED/20347082
- Nakamura H; Komatsu K; Ayaki M; Kawamoto S; Murakami M; Uoshima N; Yagi T; Hasegawa T; Yasumi M; Karasuno T; Teshima H; Hiraoka A; Masaoka T; Department of Tumor Biochemistry, the Fifth Department of; Medicine, Osaka Medical Center for Cancer and Cardiovascular; Diseases, Osaka, Japan.
- BACKGROUND: Acute graft-versus-host disease still represents the major factor that limits successful allogeneic bone marrow transplantation. Cytokines released by type 1 T-helper cells are thought to play a pivotal role in acute graft-versus-host disease. OBJECTIVE: This study was performed to investigate whether the
- Nosocomial bacteremia in HIV patients: the role of peripheral venous catheters.
- Infect Control Hosp Epidemiol. 2000 May;21(5):330-3. Unique Identifier : AIDSLINE MED/20281073
- Lambotte O; Lucet JC; Fleury L; Joly-Guillou ML; Bouvet E; Infectious Diseases Department, Bichat Claude Bernard Hospital,; Paris, France.
- A retrospective case-control study compared 40 human immunodeficiency virus (HV)-infected patients with 43 nosocomial bacteremias (NB) to 77 HIV-infected patients without NB. Presence of a peripheral venous catheter (PVC) was associated with occurrence of NB and was significantly more frequent in NB without an identif
- CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation.
- J Exp Med. 2000 Jul 17;192(2):205-18. Unique Identifier : AIDSLINE MED/20359441
- Sato N; Ahuja SK; Quinones M; Kostecki V; Reddick RL; Melby PC; Kuziel WA; Ahuja SS; South Texas Veterans Health Care System, Audie L. Murphy; Division, Austin, 78712-1095, USA.
- There is growing evidence that chemokines and their receptors regulate the movement and interaction of antigen-presenting cells such as dendritic cells (DCs) and T cells. We tested the hypothesis that the CC chemokine receptor (CCR)2 and CCR5 and the chemokine macrophage inflammatory protein (MIP)-1alpha, a ligand for
- HIV-risk practices among homeless and low-income housed mothers.
- J Fam Pract. 1999 Nov;48(11):859-67. Unique Identifier : AIDSLINE MED/20362868
- Weinreb L; Goldberg R; Lessard D; Perloff J; Bassuk E; Department of Family Medicine and Community Health, University of; Massachusetts Medical School, Worcester 01655-0309, USA.
- BACKGROUND: Knowledge of human immunodeficiency virus (HIV) and its risk behaviors have not been systematically studied in homeless mothers. The identification of the factors associated with HIV-risk practices will guide interventions for low-income housed and homeless women. METHODS: We interviewed 220 homeless and 2
- [Application of radionuclides in pharmaceutical fields]
- Yakugaku Zasshi. 2000 Jun;120(6):506-19. Unique Identifier : AIDSLINE MED/20318065
- Tanaka A; Laboratory of Drug Analysis, Showa Pharmaceutical University,; Tokyo, Japan.
- Application studies of radionuclides in pharmaceutical fields are described concerning two major categories, such as the use of gamma-emitter in nuclear medicine and beta-emitter in tracer investigation. In the former radionuclide an effort has been made to develop radioactive new diagnostic agents in the nephro-urolo
- Reductions in salivary cortisol are associated with mood improvement during relaxation training among HIV-seropositive men.
- J Behav Med. 2000 Apr;23(2):107-22. Unique Identifier : AIDSLINE MED/20293585
- Cruess DG; Antoni MH; Kumar M; Schneiderman N; Department of Psychology, University of Miami, Coral Gables,; Florida 33124-2070, USA.
- This study examined salivary cortisol and mood during relaxation training in 30 symptomatic, HIV+ gay men participating in a 10-week, group-based cognitive-behavioral stress management intervention. Cortisol levels and mood were assessed within these sessions just before and after 45-min relaxation exercises given as
- Personal, cognitive, behavioral, and demographic predictors of HIV testing and STDs in homeless women.
- J Behav Med. 2000 Apr;23(2):123-47. Unique Identifier : AIDSLINE MED/20293586
- Nyamathi AM; Stein JA; Swanson JM; School of Nursing, University of California, Los Angeles; 90095-1702, USA. ANYAMATH@SONNET.UCLA.EDU
- Using a multiracial sample of 621 homeless women, we tested a latent variable causal model of personal, cognitive, behavioral, and demographic predictors of two coping mediators and the outcome variables of HIV testing and return for test results and a recent STD infection. HIV testing and return were predicted by mor
- Hispanic adults' beliefs, attitudes, and intentions regarding the female condom.
- J Behav Med. 2000 Apr;23(2):181-206. Unique Identifier : AIDSLINE MED/20293589
- Bogart LM; Cecil H; Pinkerton SD; Department of Psychology, Kent State University, Ohio 44242, USA.
- The present study used the theory of planned behavior (TPB) (Ajzen, 1985) augmented by AIDS knowledge to investigate factors influencing intentions of Hispanic adults to use the female condom. A total of 146 persons (75 women and 71 men; mean age, 27 years) recruited from community-based organizations completed an ano
- Continuation of high-risk behavior by HIV-positive drug users. Treatment implications.
- J Subst Abuse Treat. 2000 Jul;19(1):15-22. Unique Identifier : AIDSLINE MED/20327804
- Avants SK; Warburton LA; Hawkins KA; Margolin A; Substance Abuse Center, Yale University School of Medicine, New; Haven, CT 06519, USA. kelly.avants@yale.edu
- Drug users who are positive for the human immunodeficiency virus (HIV) represent a major vector of HIV transmission, yet relatively little is known about their continued drug- and sex-related HIV-risk behavior, which may impede the development of effective risk-reduction interventions. In this study, 50 HIV-seropositi
- HIV risk behaviors in male substance abusers with and without antisocial personality disorder.
- J Subst Abuse Treat. 2000 Jul;19(1):59-66. Unique Identifier : AIDSLINE MED/20327810
- Kelley JL; Petry NM; Alcohol Research Center, Department of Psychiatry, University of; Connecticut Health Center, Farmington 06030-1517, USA.
- Antisocial personality disorder (ASP) is common in male substance abusers and may be associated with increased human immunodeficiency virus (HIV) risk behaviors. In this study, 91 male substance abusers were recruited from the community, and 42% met diagnostic criteria for ASP. Although ASP and non-ASP subjects demons
- Services provided during methadone treatment. A gender comparison.
- J Subst Abuse Treat. 2000 Jul;19(1):7-14. Unique Identifier : AIDSLINE MED/20327803
- Rowan-Szal GA; Chatham LR; Joe GW; Simpson DD; Institute of Behavioral Research, Texas Christian University,; Fort Worth, TX 76129, USA. ibr@tcu.edu
- Greater improvement in posttreatment outcomes has been shown in programs that tailor frequency and type of services to unique client needs. Using a sample of 635 clients (199 females and 436 males) admitted to three community-based methadone treatment programs, this study examined gender differences in services needed
- Suppression of acute viremia by short-term postexposure prophylaxis of simian/human immunodeficiency virus SHIV-RT-infected monkeys with a novel reverse transcriptase inhibitor (GW420867) allows for development of potent antiviral immune responses resulting in efficient containment of infection.
- J Virol. 2000 Jul;74(13):5747-53. Unique Identifier : AIDSLINE MED/20304963
- Mori K; Yasutomi Y; Sawada S; Villinger F; Sugama K; Rosenwith B; Heeney JL; Uberla K; Yamazaki S; Ansari AA; Rubsamen-Waigmann H; AIDS Research Center, National Institute of Infectious Diseases,; Tokyo Japan. mori@nih.go.jp
- A nonnucleoside reverse transcriptase (RT) inhibitor, GW420867, was tested for postexposure prophylaxis (PEP) in rhesus macaques experimentally infected with 100 50% tissue culture infective doses of a chimeric simian/human immunodeficiency virus (SHIV) containing the RT gene of HIV-1 (SHIV-RT). Animals were either mo
- Feline leukemia virus envelope sequences that affect T-cell tropism and syncytium formation are not part of known receptor-binding domains.
- J Virol. 2000 Jul;74(13):5754-61. Unique Identifier : AIDSLINE MED/20304964
- Gwynn SR; Hankenson FC; Lauring AS; Rohn JL; Overbaugh J; Program in Molecular and Cellular Biology, University of; Washington, Seattle 98109-1024, USA.
- The envelope protein is a primary pathogenic determinant for T-cell-tropic feline leukemia virus (FeLV) variants, the best studied of which is the immunodeficiency-inducing virus, 61C. We have previously demonstrated that T-cell-tropic, cytopathic, and syncytium-inducing viruses evolve in cats infected with a relative
- Differential pathogenicity of two feline leukemia virus subgroup A molecular clones, pFRA and pF6A.
- J Virol. 2000 Jul;74(13):5796-801. Unique Identifier : AIDSLINE MED/20304969
- Phipps AJ; Chen H; Hayes KA; Roy-Burman P; Mathes LE; Department of Veterinary Biosciences, The Ohio State University,; Columbus 43210, USA.
- F6A, a molecular clone of subgroup A feline leukemia virus (FeLV) is considered to be highly infectious but weakly pathogenic. In recent studies with a closely related subgroup A molecular clone, FRA, we demonstrated high pathogenicity and a strong propensity to undergo recombination with endogenous FeLV (enFeLV), lea
- Enhanced binding of antibodies to neutralization epitopes following thermal and chemical inactivation of human immunodeficiency virus type 1.
- J Virol. 2000 Jul;74(13):5802-9. Unique Identifier : AIDSLINE MED/20304970
- Grovit-Ferbas K; Hsu JF; Ferbas J; Gudeman V; Chen IS; Department of Medicine, UCLA School of Medicine, Los Angeles, CA; 90095, USA.
- Inactivation of viral particles is the basis for several vaccines currently in use. Initial attempts to use simian immunodeficiency virus to model a killed human immunodeficiency virus type 1 (HIV-1) vaccine were unsuccessful, and limited subsequent effort has been directed toward a systematic study of the requirement
- The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques.
- J Virol. 2000 Jul;74(13):5836-44. Unique Identifier : AIDSLINE MED/20304974
- Shacklett BL; Weber CJ; Shaw KE; Keddie EM; Gardner MB; Sonigo P; Luciw PA; Aaron Diamond AIDS Research Center, New York, NY, USA.
- The human and simian immunodeficiency virus (HIV-1 and SIVmac) transmembrane proteins contain unusually long intracytoplasmic domains (ICD-TM). These domains are suggested to play a role in envelope fusogenicity, interaction with the viral matrix protein during assembly, viral infectivity, binding of intracellular cal
- Kinetic analysis of human immunodeficiency virus type 1 assembly reveals the presence of sequential intermediates.
- J Virol. 2000 Jul;74(13):5845-55. Unique Identifier : AIDSLINE MED/20304975
- Tritel M; Resh MD; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, and; Graduate Program in Cell Biology and Genetics, Weill Graduate; School of Medical Sciences of Cornell University, New York, NY; 10021, USA.
- The assembly and budding of lentiviruses, such as human immunodeficiency virus type 1 (HIV-1), are mediated by the Gag protein precursor, but the molecular details of these processes remain poorly defined. In this study, we have combined pulse-chase techniques with density gradient centrifugation to identify, isolate,
- Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element.
- J Virol. 2000 Jul;74(13):5863-71. Unique Identifier : AIDSLINE MED/20304977
- Kang Y; Bogerd HP; Cullen BR; Department of Genetics, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- There is now convincing evidence that the human Tap protein plays a critical role in mediating the nuclear export of mRNAs that contain the Mason- Pfizer monkey virus constitutive transport element (CTE) and significant evidence that Tap also participates in global poly(A)(
- Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.
- J Virol. 2000 Jul;74(13):5896-901. Unique Identifier : AIDSLINE GENBANK/AJ249159
- Seiler P; Senn BM; Klenerman P; Kalinke U; Hengartner H; Zinkernagel RM; Department of Pathology, Institute of Experimental Immunology,; University of Zurich, Switzerland. seiler@mpiib-berlin.mpg.de
- Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of a neutralizing antibody response to avoid the appearance of neutralization-resistant virus variants. Despite the fact t
- Optimized viral dose and transient immunosuppression enable herpes simplex virus ICP0-null mutants To establish wild-type levels of latency in vivo.
- J Virol. 2000 Jul;74(13):5957-67. Unique Identifier : AIDSLINE MED/20304988
- Halford WP; Schaffer PA; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6076, USA.
- The reduced efficiency with which herpes simplex virus type 1 (HSV-1) mutants establish latent infections in vivo has been a fundamental obstacle in efforts to determine the roles of individual viral genes in HSV-1 reactivation. For example, in the absence of the nonessential viral immediate-early protein, ICP0, HSV
- Cellular and viral specificities of human immunodeficiency virus type 1 vif protein.
- J Virol. 2000 Jul;74(13):5982-7. Unique Identifier : AIDSLINE MED/20304990
- Madani N; Kabat D; Department of Biochemistry and Molecular Biology, Oregon Health; Sciences University, Portland 97201-3098, USA.
- The vif gene of human immunodeficiency virus type 1 (HIV-1) greatly enhances the infectivity of HIV-1 virions that are released from cells classified as nonpermissive (e.g., lymphocytes, macrophages, and H9 leukemic T cells) but is irrelevant in permissive cells (e.g., HeLa or COS cells). Recently, it was reported tha
- Enhancement of primary and secondary cellular immune responses against human immunodeficiency virus type 1 gag by using DNA expression vectors that target Gag antigen to the secretory pathway.
- J Virol. 2000 Jul;74(13):5997-6005. Unique Identifier : AIDSLINE MED/20304992
- Qiu JT; Liu B; Tian C; Pavlakis GN; Yu XF; Department of Molecular Microbiology and Immunology, The Johns; Hopkins School of Hygiene & Public Health, Baltimore, MD 21205,; USA.
- In this study, we have investigated the influence of antigen targeting after DNA vaccination upon the induction of cellular immune responses against human immunodeficiency virus type 1 (HIV-1) Gag. In addition to the standard version of HIV-1 Gag, we constructed Gag expression vectors that encode a secreted (Sc-Gag) a
- Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral entry into the central nervous system.
- J Virol. 2000 Jul;74(13):6021-30. Unique Identifier : AIDSLINE MED/20304995
- Romero IA; Prevost MC; Perret E; Adamson P; Greenwood J; Couraud PO; Ozden S; CNRS UPR 0415, Institut Cochin de Genetique Moleculaire, 75014; Paris, France. i.romero@open.ac.uk
- Human T-cell leukemia virus type 1 (HTLV-1) is associated with a variety of clinical manifestations, including tropical spastic paraparesis or HTLV-1-associated myelopathy (TSP/HAM). Viral detection in the central nervous system (CNS) of TSP/HAM patients demonstrates the ability of HTLV-1 to cross the blood-brain barr
- Binding of Tat to TAR and recruitment of positive transcription elongation factor b occur independently in bovine immunodeficiency virus.
- J Virol. 2000 Jul;74(13):6039-44. Unique Identifier : AIDSLINE MED/20304997
- Barboric M; Taube R; Nekrep N; Fujinaga K; Peterlin BM; Departments of Medicine and Microbiology and Immunology,; University of California, San Francisco 94143-0703, USA.
- Transcriptional transactivators (Tat) from many lentiviruses interact with their cognate transactivation response RNA structures (TAR) to increase rates of elongation rather than initiation of transcription. For several of them, the complex of Tat and a species-specific cyclin T1 must be formed before the binding to T
- A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G(1) cell cycle arrest.
- J Virol. 2000 Jul;74(13):6058-67. Unique Identifier : AIDSLINE MED/20305000
- Nishizawa M; Kamata M; Katsumata R; Aida Y; Tsukuba Life Science Center, The Institute of Physical and; Chemical Research (RIKEN), Ibaraki 305-0074, Japan.
- Viral protein R (Vpr) of human immunodeficiency virus type 1 inhibits cell proliferation by arresting the cell cycle at the G(2) phase and inducing to apoptosis after G(2) arrest. We have reported previously that C81, a carboxy-terminally truncated form of Vpr, interferes with cell proliferation via a novel pathway th
- Epstein-Barr virus EB2 protein exports unspliced RNA via a Crm-1-independent pathway.
- J Virol. 2000 Jul;74(13):6068-76. Unique Identifier : AIDSLINE MED/20305001
- Farjot G; Buisson M; Duc Dodon M; Gazzolo L; Sergeant A; Mikaelian I; U412 INSERM, ENS-Lyon, France.
- Human herpesviruses encode posttranscriptional activators that are believed to up-regulate viral replication by facilitating early and late gene expression. We have reported previously that the Epstein-Barr virus protein EB2 (also called M or SM) promotes nuclear export of RNAs that are poor substrates for spliceosome
- Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells.
- J Virol. 2000 Jul;74(13):6087-95. Unique Identifier : AIDSLINE MED/20305003
- Hu J; Gardner MB; Miller CJ; California Regional Primate Research Center, School of Medicine,; University of California, Davis 95616, USA.
- Despite recent insights into mucosal human immunodeficiency virus (HIV) transmission, the route used by primate lentiviruses to traverse the stratified squamous epithelium of mucosal surfaces remains undefined. To determine if dendritic cells (DC) are used by primate lentiviruses to traverse the epithelial barrier of
- The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus.
- J Virol. 2000 Jul;74(13):6117-25. Unique Identifier : AIDSLINE MED/20305006
- Kimura T; Griffin DE; W. Harry Feinstone Department of Molecular Microbiology and; Immunology, School of Hygiene and Public Health, Johns Hopkins; University, Baltimore, MD 21205, USA.
- Little is known about the role of CD8(+) T cells infiltrating the neural parenchyma during encephalitis induced by neurovirulent Sindbis virus (NSV). NSV preferentially infects neurons in the mouse brain and spinal cord; however, it is generally accepted that neurons can express few if any major histocompatibility com
- Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression.
- J Virol. 2000 Jul;74(13):6132-46. Unique Identifier : AIDSLINE MED/20305008
- Pepperl S; Munster J; Mach M; Harris JR; Plachter B; Institute for Virology, University of Mainz, Germany.
- Infection of fibroblast cell cultures with human cytomegalovirus (HCMV) leads to the production of significant amounts of defective enveloped particles, termed dense bodies (DB). These noninfectious structures contain major antigenic determinants which are responsible for induction
- The C-terminal proline-rich tail of human immunodeficiency virus type 2 Vpx is necessary for nuclear localization of the viral preintegration complex in nondividing cells.
- J Virol. 2000 Jul;74(13):6162-7. Unique Identifier : AIDSLINE MED/20305011
- Pancio HA; Vander Heyden N; Ratner L; Departments of Medicine, Pathology, and Molecular Microbiology,; Washington University School of Medicine, St. Louis, MO 63110,; USA.
- Human immunodeficiency virus type 2 (HIV-2), like other lentiviruses, is capable of infecting nondividing T cells and macrophages. The present work shows that in HIV-2-infected cells, Vpx is necessary for efficient nuclear import of the preintegration complex. In agreement with this finding, the subcellular localizati
- Interaction of human immunodeficiency virus type 2 Vpx and invariant chain.
- Unique Identifier : AIDSLINE MED/20305012
- Pancio HA; Vander Heyden N; Kosuri K; Cresswell P; Ratner L; Department of Medicine, Pathology, and Molecular Microbiology,; Washington University School of Medicine, St. Louis, Missouri; 63110, USA.
- Vpx is a virion-associated protein of human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency viruses. The yeast two-hybrid system was used to identify invariant chain (Ii) as a cellular protein that interacts with HIV-2 Vpx. Vpx-Ii interaction was confirmed in cell-free reactions using bacterially exp
- Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficiency virus type 1 gp41.
- J Virol. 2000 Jul;74(13):6186-92. Unique Identifier : AIDSLINE MED/20305015
- Gorny MK; Zolla-Pazner S; Department of Pathology, New York University School of Medicine,; New York, NY 10016, USA.
- Human immunodeficiency virus type 1 (HIV-1) entry into target cells appears to be triggered when two heptad repeat regions in the ectodomain of gp41 associate, converting the prefusogenic form of gp41 to a fusogenic form. Peptides from these two heptad repeat regions, designated N51 and C43, form a coiled coil consist
- Isolation of human immunodeficiency virus type 1 cores: retention of Vpr in the absence of p6(gag).
- J Virol. 2000 Jul;74(13):6198-202. Unique Identifier : AIDSLINE MED/20305017
- Accola MA; Ohagen A; Gottlinger HG; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, Boston, MA 02115, USA.
- Mature human immunodeficiency virus type 1 (HIV-1) virions contain a typically cone-shaped core that encases the viral genome. In this study, we established conditions which allowed the efficient isolation of morphologically intact HIV-1 cores from virions. The isolated cores consisted mostly of cones which appeared u
- Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line.
- J Virol. 2000 Jul;74(13):6207-12. Unique Identifier : AIDSLINE MED/20305019
- Gradoville L; Gerlach J; Grogan E; Shedd D; Nikiforow S; Metroka C; Miller G; Department of Pediatrics, Yale University School of Medicine, New; Haven, CT 06520, USA.
- Rta, the gene product of Kaposi s sarcoma-associated herpesvirus (KSHV) encoded mainly in open reading frame 50 (ORF50), is capable of activating expression of viral lytic cycle genes. What was not demonstrated in previous studies was whether KSHV Rta was competent to initiate the entire viral lytic life cycle includi
- Coreceptor-dependent inhibition of the cell fusion activity of simian immunodeficiency virus Env proteins.
- J Virol. 2000 Jul;74(13):6217-22. Unique Identifier : AIDSLINE MED/20305021
- Yang C; Yang Q; Compans RW; Department of Microbiology and Immunology, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.
- The cytoplasmic tail (R peptide) sequence is able to regulate the fusion activity of the murine leukemia virus (MuLV) envelope (Env) protein. We have previously shown that this sequence exerts a profound inhibitory effect on the fusion activity of simian immunodeficiency virus (SIV)-MuLV chimeric Env proteins which co
- CD4-independent, CCR5-dependent simian immunodeficiency virus infection and chemotaxis of human cells.
- J Virol. 2000 Aug;74(15):6720-4. Unique Identifier : AIDSLINE MED/20347332
- Iyengar S; Schwartz DH; Clements JE; Hildreth JE; Department of Molecular Microbiology and Immunology, School of; Public Health, Johns Hopkins University, Baltimore, Maryland; 21205, USA.
- Most simian immunodeficiency virus (SIV), human immunodeficiency virus type 2 (HIV-2), and HIV-1 infection of host peripheral blood mononuclear cells (PBMCs) is CD4 dependent. In some cases, X4 HIV-1 chemotaxis is CD4 independent, and cross-species transmission might be facilitated by CD4-independent entry, which has
- Human immunodeficiency virus type 1 virion density is not determined by nucleocapsid basic residues.
- J Virol. 2000 Aug;74(15):6734-40. Unique Identifier : AIDSLINE MED/20347334
- Cimarelli A; Luban J; Department of Microbiology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.
- The human immunodeficiency virus type 1 (HIV-1) Gag polyprotein is sufficient for assembly and release of virion-like particles from the plasma membrane. To promote assembly, the Gag polyprotein must polymerize to form a shell that lines the inner membrane of nascent virions. Several techniques have been used to funct
- Type 2 cytokines predominate in the human CD4(+) T-lymphocyte response to Epstein-Barr virus nuclear antigen 1.
- J Virol. 2000 Aug;74(15):6748-59. Unique Identifier : AIDSLINE MED/20347336
- Steigerwald-Mullen P; Kurilla MG; Braciale TJ; Beirne B. Carter Center for Immunology Research, University of; Virginia Health Sciences Center, Charlottesville, Virginia 22908,; USA.
- Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that persistently infects 85% of the adult population worldwide. In this report, we examine the proliferative response and cytokine secretion profile of CD4(+) T lymphocytes from a panel of unrelated EBV-positive donors against two EBV latent antigens, EBNA1 a
- V2 loop glycosylation of the human immunodeficiency virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodies.
- J Virol. 2000 Aug;74(15):6769-76. Unique Identifier : AIDSLINE MED/20347338
- Ly A; Stamatatos L; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10021-6399, USA. lstamata@adarc.org
- We examined the role of asparagine-linked glycosylation of the V2 loop of the human immunodeficiency virus (HIV) SF162 envelope on viral replication potential and neutralization susceptibility. We report that the asparagines located at the amino- and carboxy-terminal sites (at positions 154 and 195, respectively), as
- Effective vaccine for lassa fever.
- J Virol. 2000 Aug;74(15):6777-83. Unique Identifier : AIDSLINE MED/20347339
- Fisher-Hoch SP; Hutwagner L; Brown B; McCormick JB; Special Pathogens Branch, Division of Viral, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA.
- Lassa fever has been estimated to cause 5,000 deaths annually in West Africa. Recently, war in the zone where Lassa fever is hyperendemic has severely impeded control and treatment. Vaccination is the most viable control measure. There is no correlation between antibody levels and outcome in human patients, and inacti
- The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.
- J Virol. 2000 Aug;74(15):6790-9. Unique Identifier : AIDSLINE MED/20347341
- Coull JJ; Romerio F; Sun JM; Volker JL; Galvin KM; Davie JR; Shi Y; Hansen U; Margolis DM; Division of Infectious Diseases, University of Texas Southwestern; Medical Center, Dallas, Texas 75390-9113, USA.
- Enigmatic mechanisms restore the resting state in activated lymphocytes following human immunodeficiency virus type 1 (HIV-1) infection, rarely allowing persistent nonproductive infection. We detail a mechanism whereby cellular factors could establish virological latency. The transcription factors YY1 and LSF cooperat
- Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
- J Virol. 2000 Aug;74(15):6849-55. Unique Identifier : AIDSLINE MED/20347347
- Moriuchi H; Moriuchi M; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. hiromori@net.nagasaki-u.ac.jp
- Neutrophils dominate acute inflammatory responses that generally evolve into chronic inflammatory reactions mediated by monocyte/macrophages and lymphocytes. The latter cell types also serve as major targets for human immunodeficiency virus type 1 (HIV-1). In this study we have investigated the role of neutrophil prod
- Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function.
- J Virol. 2000 Aug;74(15):6866-74. Unique Identifier : AIDSLINE MED/20347349
- Mahieux R; Pise-Masison CA; Lambert PF; Nicot C; De Marchis L; Gessain A; Green P; Hall W; Brady JN; Laboratory of Receptor Biology and Gene Expression,National; Cancer Institute, National Institutes of Health, Bethesda,; Maryland 20892, USA.
- We have analyzed the functional activity of the p53 tumor suppressor in human T-cell lymphotropic virus type 2 (HTLV-2)-transformed cells. Abundant levels of the p53 protein were detected in both HTLV-2A and -2B virus-infected cell lines. The p53 was functionally inactive, however, both in transient-transfection assay
- Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cells.
- J Virol. 2000 Aug;74(15):6893-910. Unique Identifier : AIDSLINE MED/20347352
- Zhang Y; Lou B; Lal RB; Gettie A; Marx PA; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10016, USA.
- We have used coreceptor-targeted inhibitors to investigate which coreceptors are used by human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency viruses (SIV), and human immunodeficiency virus type 2 (HIV-2) to enter peripheral blood mononuclear cells (PBMC). The inhibitors are TAK-779, which is specific
- Quantitation of CD8(+) T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes.
- J Virol. 2000 Aug;74(15):6922-34. Unique Identifier : AIDSLINE MED/20347354
- Mylin LM; Schell TD; Roberts D; Epler M; Boesteanu A; Collins EJ; Frelinger JA; Joyce S; Tevethia SS; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey, Pennsylvania 17033, USA.
- The cytotoxic T-lymphocyte response to wild-type simian virus 40 large tumor antigen (Tag) in C57BL/6 (H2(b)) mice is directed against three H2-D(b)-restricted epitopes, I, II/III, and V, and one H2-K(b)-restricted epitope, IV. Epitopes I, II/III, and IV are immunodominant, while epitope V is immunorecessive. We inves
- Short- and long-term clinical outcomes in rhesus monkeys inoculated with a highly pathogenic chimeric simian/human immunodeficiency virus.
- J Virol. 2000 Aug;74(15):6935-45. Unique Identifier : AIDSLINE MED/20347355
- Endo Y; Igarashi T; Nishimura Y; Buckler C; Buckler-White A; Plishka R; Dimitrov DS; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.
- A highly pathogenic simian/human immunodeficiency virus (SHIV), SHIV(DH12R), isolated from a rhesus macaque that had been treated with anti-human CD8 monoclonal antibody at the time of primary infection with the nonpathogenic, molecularly cloned SHIV(DH12), induced marked and rapid CD4(+) T cell loss in all rhesus mac
- CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor.
- J Virol. 2000 Aug;74(15):6946-52. Unique Identifier : AIDSLINE MED/20347356
- Lee S; Tiffany HL; King L; Murphy PM; Golding H; Zaitseva MB; Division of Viral Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, National Institutes of; Health, Bethesda, Maryland 20892, USA.
- To determine whether human immunodeficiency virus type 1 (HIV-1) coreceptors besides CXCR4 and CCR5 are involved in HIV-1 infection of the thymus, we focused on CCR8, a receptor for the chemokine I-309, because of its high expression in the thymus. Similar levels of CCR8 mRNA were detected in immature and mature prima
- Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses.
- J Virol. 2000 Aug;74(15):6984-91. Unique Identifier : AIDSLINE MED/20347360
- Luzuriaga K; McManus M; Catalina M; Mayack S; Sharkey M; Stevenson M; Sullivan JL; Department of Pediatrics, University of Massachusetts Medical; School, Worcester, Massachusetts 01605, USA.; katherine.luzuriaga@umassmed.edu
- Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labi
- Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1.
- J Virol. 2000 Aug;74(15):7005-15. Unique Identifier : AIDSLINE MED/20347362
- Kuhmann SE; Platt EJ; Kozak SL; Kabat D; Department of Biochemistry and Molecular Biology, Oregon Health; Sciences University, Portland, Oregon 97201-3098, USA.
- In addition to the primary cell surface receptor CD4, CCR5 or another coreceptor is necessary for infections by human immunodeficiency virus type 1 (HIV-1), yet the mechanisms of coreceptor function and their stoichiometries in the infection pathway remain substantially unknown. To address these issues, we studied the
- The interaction of vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 In vivo mutation rate.
- J Virol. 2000 Aug;74(15):7039-47. Unique Identifier : AIDSLINE MED/20347366
- Mansky LM; Preveral S; Selig L; Benarous R; Benichou S; Department of Molecular Virology, Immunology, and Medical; Genetics, Center for Retrovirus Research, and Comprehensive; Cancer Center, Ohio State University Medical Center, Columbus,; Ohio 43210, USA. mansky.3@osu.edu
- The Vpr protein of human immunodeficiency virus type 1 (HIV-1) influences the in vivo mutation rate of the virus. Since Vpr interacts with a cellular protein implicated in the DNA repair process, uracil DNA glycosylase (UNG), we have explored the contribution of this interaction to the mutation rate of HIV-1. Single-a
- Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.
- J Virol. 2000 Aug;74(15):7096-107. Unique Identifier : AIDSLINE MED/20347373
- Nyambi PN; Mbah HA; Burda S; Williams C; Gorny MK; Nadas A; Zolla-Pazner S; Department of Pathology, New York University School of Medicine,; New York, New York 10016, USA.
- We have examined the exposure and conservation of antigenic epitopes on the surface envelope glycoproteins (gp120 and gp41) of 26 intact, native, primary human immunodeficiency virus type 1 (HIV-1) group M virions of clades A to H. For this, 47 monoclonal antibodies (MAbs) derived from HIV-1-infected patients were use
- The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.
- J Virol. 2000 Aug;74(15):7119-26. Unique Identifier : AIDSLINE MED/20347375
- Petit C; Schwartz O; Mammano F; Unite Retrovirus et Transfert Genetique, Institut Pasteur,; Paris, France.
- Integrase (IN) is a key component of the preintegration nucleoprotein complex (PIC), which transports the retroviral genome from the cytoplasm to the nucleus of newly infected cells. Retroviral IN proteins have intrinsic karyophilic properties, which for human immunodeficiency virus type 1 (HIV-1) are currently attrib
- Characterization of a macaque recombinant monoclonal antibody that binds to a CD4-induced epitope and neutralizes simian immunodeficiency virus.
- J Virol. 2000 Aug;74(15):7158-63. Unique Identifier : AIDSLINE MED/20347380
- Glamann J; Hirsch VM; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Rockville, Maryland 20852, USA.
- A potent neutralizing Fab fragment from a long-term survivor of simian immunodeficiency virus (SIVsm) infection was used to construct a recombinant macaque immunoglobulin G1kappa (IgG1kappa) molecule, designated IgG1-201. A Chinese hamster ovary cell line expressing IgG1-201 was derived by stable transfection and opti
- Two putative alpha-helical domains of human immunodeficiency virus type 1 Vpr mediate nuclear localization by at least two mechanisms.
- J Virol. 2000 Aug;74(15):7179-86. Unique Identifier : AIDSLINE MED/20347383
- Kamata M; Aida Y; RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305-0074, Japan.
- To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions within putative domains. Immunofluorescence staining of transfected cells revealed that wild-type Vpr was localized predomin
- The Internet as a newly emerging risk environment for sexually transmitted diseases [see comments]
- JAMA. 2000 Jul 26;284(4):443-6. Unique Identifier : AIDSLINE MED/20366357
- McFarlane M; Bull SS; Rietmeijer CA; Division of Sexually Transmitted Disease Prevention, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.; MmcFarlane@cdc.gov
- CONTEXT: Transmission of sexually transmitted diseases (STDs) such as human immunodeficiency virus (HIV) infection is associated with unprotected sex among multiple anonymous sex partners. The role of the Internet in risk of STDs is not known. OBJECTIVE: To compare risk of STD transmission for persons who seek sex par
- The natural history of hepatitis C virus infection: host, viral, and environmental factors.
- JAMA. 2000 Jul 26;284(4):450-6. Unique Identifier : AIDSLINE MED/20366359
- Thomas DL; Astemborski J; Rai RM; Anania FA; Schaeffer M; Galai N; Nolt K; Nelson KE; Strathdee SA; Johnson L; Laeyendecker O; Boitnott J; Wilson LE; Vlahov D; Department of Medicine, Johns Hopkins Medical Institutions,; Baltimore, MD 21205, USA.
- CONTEXT: Hepatitis C virus (HCV) infection may resolve (viral clearance), persist without complications, or cause end-stage liver disease (ESLD). The frequency and determinants of these outcomes are poorly understood. OBJECTIVE: To assess the incidence and determinants of viral clearance and ESLD among persons who acq
- Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial.
- JAMA. 2000 Jul 26;284(4):472-7. Unique Identifier : AIDSLINE MED/20366362
- Hadigan C; Corcoran C; Basgoz N; Davis B; Sax P; Grinspoon S; Neuroendocrine Unit, Bulfinch 457B, Massachusetts General; Hospital, Boston, MA 02114, USA.
- CONTEXT: A syndrome of lipodystrophy, characterized by fat redistribution and insulin resistance, has been estimated to affect the majority of human immunodeficiency virus (HIV)-infected individuals who are treated with combination antiretroviral therapy. There are no proven therapies for the metabolic disturbances as
- [Present status of infectious diseases transmitted by blood transfusion and the preventive measures]
- Masui. 1999;48 Suppl:S33-40. Unique Identifier : AIDSLINE MED/20247682
- Shimoyama T
- [Vaccination of chronic myelogenous leukemia patients with peptide-pulsed dendritic cells]
- Rinsho Ketsueki. 2000 Apr;41(4):292-5. Unique Identifier : AIDSLINE MED/20305813
- Takahashi T; Tanaka Y
- [Reactivation of hepatitis B virus after autologous peripheral blood stem cell transplantation in patients with positive hepatitis B surface antibodies]
- Rinsho Ketsueki. 2000 Apr;41(4):322-8. Unique Identifier : AIDSLINE MED/20305818
- Endo T; Sawada K; Fujimoto K; Yamamoto S; Takashima H; Haseyama Y; Nishio M; Koizumi K; Koike T; Department of Internal Medicine II, Hokkaido University School of; Medicine.
- Hepatitis B virus (HBV) reactivation in patients with positive hepatitis B surface antibody (HBsAb) has been reported in some cases of allogenic bone marrow transplantation, acquired immunodeficiency syndrome (AIDS), and organ transplantation. However, to our knowledge, no reports have been made on the frequency and r
- Effects of acupuncture on the immunological functions in hepatitis B virus carriers.
- J Tradit Chin Med. 1999 Dec;19(4):268-72. Unique Identifier : AIDSLINE MED/20376544
- Chen J; Chen M; Zhao B; Wang Y; First Municipal Hospital, Zhuzhou, Hunan Province.
- A contrast study on the effects of manual acupuncture and electroacupuncture was conducted in 60 cases of chronic hepatitis B carriers. The results demonstrated that the immunological functions, both cellular and humoral, were markedly regulated as evidenced by the negative turnover rates of HBsAg, HBeAg, anti-HBc and
- Characterization of a novel HHV-8-positive cell line reveals implications for the pathogenesis and cell cycle control of primary effusion lymphoma.
- CS/*PATHOLOGY/VIROLOGY Viral Proteins/BIOSYNTHESIS/GENETICS Virus Latency Leukemia. 2000 Jul;14(7):1301-9. Unique Identifier : AIDSLINE MED/20370228
- Carbone A; Cilia AM; Gloghini A; Capello D; Fassone L; Perin T; Rossi D; Canzonieri V; De Paoli P; Vaccher E; Tirelli U; Volpe R; Gaidano G; Divisions of Pathology, Centro di Riferimento Oncologico, IRCCS,; Istituto Nazionale Tumori, Aviano, Italy.
- CD19+ and CD20+ B cells from the peripheral blood of patients with multiple myeloma are not infected with human herpesvirus 8 [letter]
- Leukemia. 2000 Jul;14(7):1330-1. Unique Identifier : AIDSLINE MED/20370238
- Bosing T; Bellos F; Cremer FW; Gemmel C; Moldenhauer G; Ho AD; Goldschmidt H; Moos M
- Antimycobacterial therapy.
- Mayo Clin Proc. 1999 Oct;74(10):1038-48. Unique Identifier : AIDSLINE MED/20375445
- Van Scoy RE; Wilkowske CJ; Division of Infectious Diseases and Internal Medicine, Mayo; Clinic Rochester, Minnesota, USA.
- Tuberculosis is a major cause of illness and death worldwide. The epidemic of the acquired immunodeficiency syndrome and the increased number of other immunocompromised hosts have led to a remarkable increase in Mycobacterium avium-intracellulare complex infections. Adequate diagnostic, prevention, and treatment measu
- Methylphenidate: its pharmacology and uses.
- Mayo Clin Proc. 2000 Jul;75(7):711-21. Unique Identifier : AIDSLINE MED/20364831
- Challman TD; Lipsky JJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic,; Rochester, MN 55905, USA.
- Methylphenidate is a commonly used medication in the United States . This central nervous system stimulant has a mechanism of action distinct from that of amphetamine. The Food and Drug Administration has approved methylphenidate for the treatment of attention-deficit/hyperactivity diso
- National estimates of HIV-related symptom prevalence from the HIV Cost and Services Utilization Study.
- Med Care. 2000 Jul;38(7):750-62. Unique Identifier : AIDSLINE MED/20356530
- Mathews WC; McCutchan JA; Asch S; Turner BJ; Gifford AL; Kuromiya K; Brown J; Shapiro MF; Bozzette SA; University of California at San Diego, USA. cmathews@ucsd.edu
- OBJECTIVES: The objectives of this study were (1) to estimate the prevalence, bothersomeness, and variation of HIV-related symptoms in a nationally representative sample of HIV-infected adults receiving medical care and (2) to evaluate new aggregate measures of symptom frequency and bothersomeness. METHODS: Beginning
- [Role of cytokines and chemokines in the non-progression of HIV infection in vertically infected children]
- Med Clin (Barc). 2000 May 6;114(17):641-6. Unique Identifier : AIDSLINE MED/20357823
- Resino S; Bellon JM; Jimenez JL; Gurbindo MD; Munoz-Fernandez MA; Division de Inmunologia, Hospital General Universitario; Gregorio Maranon, Madrid.
- BACKGROUND: To study the cytokine production in vertically HIV-1-infected children with more of 7 years of HIV infection and different pattern of progression. PATIENTS AND METHODS: We study 32 HIV-1-infected children: 8 NA children (age > 7 years, asymptomatic or with light symptoms, without antiretroviral treatment a
- [Evolution of the new number of diagnoses of HIV infection in Asturias, Navarra and La Rioja]
- Med Clin (Barc). 2000 May 6;114(17):653-5. Unique Identifier : AIDSLINE MED/20357825
- Moreno C; Huerta I; Lezaun ME; Gonzalez A; Sola J; Castilla J; Instituto de Salud Publica y Hospital de Navarra, Pamplona.
- BACKGROUND: To describe the time-trend of people diagnosed with HIV infection in Asturias, Navarra and La Rioja up to 1998. METHODS: HIV case reports since the beginning of the epidemic have been analysed. Only the first positive confirmed result for each patient was taken into account. RESULTS: In the three regions a
- [Cancer of the cervix uteri and impact of HIV on its development in socially disadvantaged young women (editorial)]
- Med Clin (Barc). 2000 May 6;114(17):656-7. Unique Identifier : AIDSLINE MED/20357826
- Vall Mayans M; de Sanjose Llongueras S
- Classification of drug-resistant tuberculosis in an epidemic area.
- Lancet. 2000 Jul 1;356(9223):22-5. Unique Identifier : AIDSLINE MED/20348849
- Van Rie A; Warren R; Richardson M; Gie RP; Enarson DA; Beyers N; Van Helden PD; Department of Paediatrics and Child Health, University of; Stellenbosch, South Africa.
- BACKGROUND: Traditionally, patients with drug-resistant tuberculosis are classified as having acquired drug-resistant or primary drug-resistant disease on the basis of a history of previous tuberculosis treatment. Only cases of primary drug resistance are assumed to be due to transmission of drug-resistant strains. ME
- The $64000 question in diabetes continues.. [comment]
- Lancet. 2000 Jul 1;356(9223):4-6. Unique Identifier : AIDSLINE MED/20348842
- Atkinson MA; Department of Pathology, University of Florida, Gainesville; 32610, USA.
- Detection of hepatitis C virus in the semen of infected men [letter]
- Lancet. 2000 Jul 1;356(9223):42-3. Unique Identifier : AIDSLINE MED/20348855
- Leruez-Ville M; Kunstmann JM; De Almeida M; Rouzioux C; Chaix ML
- We detected hepatitis C virus (HCV) RNA in the semen of one third of HCV viraemic men. Seminal viral loads were low, but the semen could be infectious and the role of sexual transmission in the spread of HCV infection should not be underestimated.
- Breaking the silence: setting realistic priorities for AIDS control in less-developed countries [see comments]
- Lancet. 2000 Jul 1;356(9223):55-60. Unique Identifier : AIDSLINE MED/20348866
- Ainsworth M; Teokul W; Development Research Group, World Bank, Washington, DC, USA.
- The AIDS pandemic is a human tragedy that is threatening development in the poorest countries. There is no cure or vaccine, but the tools to control the epidemic already exist. Nevertheless, there are few examples of national AIDS control programmes that have had an impact on the epidemic. We (an economist and a plann
- Oral N-acetyl-cysteome increases the production of anti HIV chemokines in peripheral blood mononuclear cells.
- Life Sci. 2000;67(2):147-54. Unique Identifier : AIDSLINE MED/20356454
- Cavallini L; Alexandre A; Department of Biological Chemistry, C.N.R. Centro di Studio delle; Biomembrane, University of Padova, Italy.
- The C-C chemokines MIP-1alpha, MIP-1beta and RANTES are specific and powerful inhibitors of HIV infectivity. They appear to work by blocking the interaction of the virus with the receptor (CCR5). The latter is utilized as a coreceptor for cell penetration by macrophage-tropic (R5) HIV strains responsible for the major
- [The progress of virology at the dawn of the year 2000]
- Med Trop (Mars). 1999;59(4 Pt 2):423-4. Unique Identifier : AIDSLINE MED/20360298
- Dormont D; Departement de Recherche Medicale du Commissariat a l'Energie; Atomique, Fontenay aux Roses, France. dominique.dormont@cea.fr
- [Viruses and civilization]
- Med Trop (Mars). 1999;59(4 Pt 2):425-9. Unique Identifier : AIDSLINE MED/20360299
- Chastel C; Laboratoire de Virologie, National de l'Academie de Medecine,; Faculte de Medecine, Brest, France. chastelc@aol.com
- A few million years ago, when primates moved from the east African forest to the savannah, they were already infected with endogenous viruses and occultly transmitted them to the prime Homo species. However it was much later with the building of the first large cities in Mesopotamia that interhuman viral transmission
- [Variability and development of viral populations: assessment and implications]
- Med Trop (Mars). 1999;59(4 Pt 2):430-4. Unique Identifier : AIDSLINE MED/20360300
- Baranowski E; Ruiz-Jarabo CM; Escarmis C; Domingo E; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad; Autonoma de Madrid, Cantoblanco, Espana. edomingo@cbm.uam.es
- RNA virus populations consist of complex distributions of closely related but not identical genomes known as viral quasi-species. The quasi-species concept describes the dynamics of these genomes subjected to a continuous process of variation, competition, and selection. Quasi-species dynamics has broad implications n
- [Genetic diversity of HIV infection worldwide and its consequences]
- Unique Identifier : AIDSLINE MED/20360303
- Peeters M; Delaporte E
- Phylogenetic study of HIV-1 strains from different geographical locations has revealed the existence of three separate groups that have been named M, N, and O. Most strains involved in the pandemia belong to group M which contains several subtypes. Nearly 20 p. 100 of isolates in group M are recombinant with genomic c
- [Reduction of mother-child transmission of HIV infection in Africa: from clinical research to public health programs]
- Med Trop (Mars). 1999;59(4 Pt 2):456-64. Unique Identifier : AIDSLINE MED/20360304
- Leroy V; Dabis F; L'Unite INSERM 330, Universite Victor Segalen Bordeaux II,; France. valeriane.leroy@u-bordeaux2.fr
- More and more African women are infected by HIV. As a result the mother-to-child transmission (MCT) rate is rising. Various prevention techniques have been assessed in randomized clinical trials in Africa but results need to be discussed to understand the full implications for prevention programs. To gain insight into
- [The HIV/AIDS pandemic: African women at the heart of the control program or the difficulties with regard to gender]
- Med Trop (Mars). 1999;59(4 Pt 2):465-7. Unique Identifier : AIDSLINE MED/20360305
- Moulin B; Louis JP; Mission du Service de Sante des Armees au Ministere des; Affaires Etrangeres, Paris, France. bmoulin@hotmail.com
- The AIDS pandemia in developing countries forces forth the question of women s rights in Africa and underscores their extreme physical and sociocultural vulnerability. Experience gained during a program designed to reduce mother-to-child transmission of HIV in the Ivory Coast
- [HTLV-1 infection in time and space]
- Med Trop (Mars). 1999;59(4 Pt 2):469-74. Unique Identifier : AIDSLINE MED/20360306
- Georges-Courbot MC; Georges AJ; Centre International de Recherche Medicale de Franceville,; Gabon. mgeorges@lyon151.inserm.fr
- Human T-cell leukemia virus type 1 (HTLV-1) is a member of the Oncoretrovirinae family containing several viruses that have been associated with a low incidence of leukemia and sarcoma in mammals. Primates are susceptible to viruses of genera HTLV (humans) and STLV (other primates). The high degree of homology in geno
- [Biohazards due to Orthopoxvirus: should we re-vaccinate against smallpox?]
- Med Trop (Mars). 1999;59(4 Pt 2):483-7. Unique Identifier : AIDSLINE MED/20360308
- Georges AJ; Georges-Courbot MC; Centre International de Recherche Medicale de Franceville,; Gabon. ajgeorges@wanadoo.fr
- Although the WHO declared global smallpox eradication in 1980, the Orthopoxvirus remains a source of concern for several reasons. Firstly, stocks of the smallpox virus have been preserved for experimental use (at least officially in the USA and Russia ) so that an escaped isolate co
- [Antiviral vaccines]
- Med Trop (Mars). 1999;59(4 Pt 2):522-6. Unique Identifier : AIDSLINE MED/20360315
- Girard M; Centre Europeen de Recherche en Immunologie et Virologie, Lyon,; France. mgirard@ens-bma.cnrs.fr
- Vaccination has been successful in controlling numerous diseases in man and animals. Smallpox has been eradicated and poliomyelitis is on the verge of being eradicated. The traditional immunization arsenal includes vaccines using live, attenuated, and inactivated organisms. DNA recombinant technology has added two new
- Preparation of specifically 2H- and 13C-labeled ribonucleotides.
- Methods Enzymol. 2000;317:18-38. Unique Identifier : AIDSLINE MED/20288079
- Scott LG; Tolbert TJ; Williamson JR; The Scripps Research Institute, La Jolla, California 92037, USA.
- Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.
- Mol Cell Biol. 2000 Aug;20(15):5363-9. Unique Identifier : AIDSLINE MED/20351574
- Knobeloch KP; Wright MD; Ochsenbein AF; Liesenfeld O; Lohler J; Zinkernagel RM; Horak I; Orinska Z; Department of Molecular Genetics, Institute of Molecular; Pharmacology, Free University of Berlin, Berlin, Hamburg,; Germany.
- CD37 is a membrane protein of the tetraspanin superfamily, which includes CD9, CD53, CD63, CD81, and CD82. Many of these molecules are expressed on leukocytes and have been implicated in signal transduction, cell-cell interactions, and cellular activation and development. We generated and analyzed mice deficient for C
- Thalidomide neuropathy: role of F-wave monitoring [letter]
- Muscle Nerve. 2000 Aug;23(8):1301-2. Unique Identifier : AIDSLINE MED/20379348
- Rao DG; Kane NM; Oware A
- Mbeki gives AIDS scientists the cold shoulder [news]
- Nature. 2000 Jul 13;406(6792):113. Unique Identifier : AIDSLINE MED/20365692
- Cherry M
- Grounds for hope on AIDS in Africa [editorial]
- Nature. 2000 Jul 20;406(6793):219. Unique Identifier : AIDSLINE MED/20372158
- Diplomatic Mandela calls for action on HIV...as South Africa considers its options after free drugs offer [news]
- Nature. 2000 Jul 20;406(6793):223. Unique Identifier : AIDSLINE MED/20372163
- Cherry M
- [Manifestations of histoplasmosis]
- Ned Tijdschr Geneeskd. 2000 Jun 17;144(25):1201-5. Unique Identifier : AIDSLINE MED/20355489
- Claessen FA; Vos MJ; Simoons-Smit AM; Debets-Ossenkopp YJ; Perenboom RM; Afd. Inwendige geneeskunde, Academisch Ziekenhuis Vrije; Universiteit, Amsterdam.
- Two patients, a 34-year old man-to-woman transsexual and a 32-year-old man, with aids presented with pulmonary symptoms, fever, serious weight loss and an oral ulcer. A third patient, a 16-year-old boy, had signs of transverse myelitis and meningitis without immunodeficiency. All were South American citizens and had d
- Immunomodulating effects of surgical intervention in tumors of the head and neck.
- Unique Identifier : AIDSLINE MED/20349682
- Dietz A; Heimlich F; Daniel V
- Kaposi's sarcoma of the tongue.
- Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):151. Unique Identifier : AIDSLINE MED/20349687
- Mra Z; Chien J; Department of Otolaryngology-Head and Neck Surgery, Montefiore; Medical Center, Albert Einstein College of Medicine, USA.
- [The eclectic cellular tropism of cytomegalovirus (editorial)]
- Pathologica. 2000 Apr;92(2):51-7. Unique Identifier : AIDSLINE MED/20297360
- Landini MP; Jahn G
- Identification and care of HIV-exposed and HIV-infected infants, children, and adolescents in foster care. American Academy of Pediatrics. Committee on Pediatric AIDS.
- Pediatrics. 2000 Jul;106(1 Pt 1):149-53. Unique Identifier : AIDSLINE MED/20347426
- As a consequence of the expanding human immunodeficiency virus (HIV) epidemic and major advances in medical management of HIV-exposed and HIV-infected persons, revised recommendations are provided for HIV testing of infants, children, and adolescents in foster care. Updated recommendations also are provided for the ca
- The effect of ritonavir on the pharmacokinetics of meperidine and normeperidine.
- Pharmacotherapy. 2000 May;20(5):549-53. Unique Identifier : AIDSLINE MED/20267338
- Piscitelli SC; Kress DR; Bertz RJ; Pau A; Davey R; Pharmacy Department, Clinical Center and Laboratory of; Immunoregulation, National Institutes of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.
- STUDY OBJECTIVE: To determine the effects of ritonavir on the pharmacokinetics of meperidine and normeperidine. DESIGN: Open-label, crossover, pharmacokinetic study. SETTING: United States government research hospital.
- [Compliance with antiretroviral therapy: the psychological dimension]
- Presse Med. 2000 Jun 24;29(22):1227-30. Unique Identifier : AIDSLINE MED/20373247
- Lahlou-Laforet K; Service de Psychologie clinique et Psychiatrie de Liaison,; Hopital Europeen Georges Pompidou, Paris.
- Production of resistant HIV mutants during antiretroviral therapy.
- Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7681-6. Unique Identifier : AIDSLINE MED/20345045
- Ribeiro RM; Bonhoeffer S; Wellcome Trust Centre for the Epidemiology of Infectious; Diseases, Department of Zoology, University of Oxford, South; Parks Road, OX1 3PS, Oxford, United Kingdom.
- HIV drug therapy often fails because of the appearance of multidrug-resistant virus. There are two possible scenarios for the outgrowth of multidrug-resistant virus in response to therapy. Resistant virus may preexist at low frequencies in drug-naive patients and is rapidly selected in the presence of drugs. Alternati
- Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity.
- Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8027-32. Unique Identifier : AIDSLINE MED/20345106
- Lu Y; Friedman R; Kushner N; Doling A; Thomas L; Touzjian N; Starnbach M; Lieberman J; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, MA 02115, USA.; yichenlu@hsph.harvard.edu
- Bacillus anthrax lethal toxin can be engineered to deliver foreign proteins to the cytosol for antigen presentation to CD8 T cells. Vaccination with modified toxins carrying 8-9 amino acid peptide epitopes induces protective immunity in mice. To evaluate whether large protein antigens can be used with this system, rec
- Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy.
- Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8039-44. Unique Identifier : AIDSLINE MED/20345108
- Emery VC; Griffiths PD; Department of Virology, Royal Free and University College Medical; School of University College, Rowland Hill Street, Hampstead,; London, NW3 2QG, United Kingdom. v.emery@rfc.ucl.ac.uk
- Cytomegalovirus ( CMV ) replicates rapidly in its human host with a doubling time of approximately 1 day. Using simple mathematical models we show that the efficacy of the anti-CMV drug ganciclovir (GCV) against wild-type strains is 91.5% [95% confidence interval
- Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis.
- Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8051-6. Unique Identifier : AIDSLINE MED/20345110
- Coscoy L; Ganem D; Howard Hughes Medical Institute and Departments of Microbiology; and Medicine, University of California, San Francisco, CA 94143,; USA.
- Down-regulation of the cell surface display of class I MHC proteins is an important mechanism of immune evasion by human and animal viruses. Herpesviruses in particular encode a variety of proteins that function to lower MHC I display by several mechanisms. These include binding and retention of MHC I chains in the en
- Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.
- Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8075-80. Unique Identifier : AIDSLINE MED/20345114
- Meucci O; Fatatis A; Simen AA; Miller RJ; Department of Neurobiology, Pharmacology, and Physiology, and; Committee on Neurobiology, University of Chicago, Chicago, IL; 60637, USA.
- Recent in vitro and in vivo studies have shown that the chemokine fractalkine is widely expressed in the brain and localized principally to neurons. Central nervous system expression of CX(3)CR1, the only known receptor for fractalkine, has been demonstrated exclusively on microglia and astrocytes. Thus, it has been p
- Adherence and drug resistance: predictions for therapy outcome.
- Proc R Soc Lond B Biol Sci. 2000 Apr 22;267(1445):835-43. Unique Identifier : AIDSLINE MED/20277280
- Wahl LM; Nowak MA; Institute for Advanced Study, Princeton, NJ 08540, USA.; wahl@ias.edu
- We combine standard pharmacokinetics with an established model of viral replication to predict the outcome of therapy as a function of adherence to the drug regimen. We consider two types of treatment failure: failure to eliminate the wild-type virus, and the emergence of drug-resistant virus. Specifically, we determi
- Hijacked receptors.
- Pharm Acta Helv. 2000 Mar;74(2-3):287-90. Unique Identifier : AIDSLINE MED/20272851
- Triggle DJ; Graduate School, State University of New York, Buffalo 14260,; USA. triggle@buffalo.edu
- Pharmacological receptors are typically defined by their selectivity of ligand recognition, including where appropriate stereoselectivity of interaction. It is increasingly clear that receptors may, in fact, be promiscuous species. This promiscuity arises at several levels of organization: two appear to be of particul
- Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines.
- Pharm Acta Helv. 2000 Mar;74(2-3):305-12. Unique Identifier : AIDSLINE MED/20272854
- Sozzani S; Allavena P; Vecchi A; Van Damme J; Mantovani A; Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.; sozzani@irfmn.mnegri.it
- Chemokines are a superfamily of proteins that play a central role in immune and inflammatory reactions and in viral infections. About 50 different chemokines divided in four subfamilies are known, CXC, CC, C, and CX3C. Chemokine receptors can function as entry/fusion co-receptors for human immunodeficiency virus (HIV)
- AIDS meeting. Companies, donors pledge to close gap in AIDS treatment [news]
- Science. 2000 Jul 21;289(5478):368-9. Unique Identifier : AIDSLINE MED/20367499
- Cohen J
- Molecular biology. Targeting intron insertion into DNA [comment] [news]
- Science. 2000 Jul 21;289(5478):374. Unique Identifier : AIDSLINE MED/20367503
- Strauss E
- Group II introns designed to insert into therapeutically relevant DNA target sites in human cells [see comments]
- Science. 2000 Jul 21;289(5478):452-7. Unique Identifier : AIDSLINE MED/20363932
- Guo H; Karberg M; Long M; Jones JP 3rd; Sullenger B; Lambowitz AM; Institute for Cellular and Molecular Biology, Department of; Chemistry and Biochemistry, and Section of Molecular Genetics and; Microbiology, School of Biological Sciences, University of Texas,; Austin, TX 78712, USA.
- Mobile group II intron RNAs insert directly into DNA target sites and are then reverse-transcribed into genomic DNA by the associated intron-encoded protein. Target site recognition involves modifiable base-pairing interactions between the intron RNA and a >14-nucleotide region of the DNA target site, as well as fixed
- Principles of treating HIV.
- S Afr Med J. 2000 Mar;90(3):227-30. Unique Identifier : AIDSLINE MED/20311860
- Johnson D
- TB--are we losing the battle?
- S Afr Med J. 2000 Mar;90(3):237-8. Unique Identifier : AIDSLINE MED/20311863
- Collins T
- Confirmation of transmission of the microsporidian parasite Enterocytozoon bieneusi in South Africa [letter]
- S Afr Med J. 2000 Mar;90(3):247-50. Unique Identifier : AIDSLINE MED/20311868
- von Gottberg AM; Dini LA; Frean JA; Grimwood AJ
- Thalidomide stimulates splenic IgM antibody response and cytotoxic T lymphocyte activity and alters leukocyte subpopulation numbers in female B6C3F1 mice.
- Toxicol Appl Pharmacol. 2000 Jun 15;165(3):237-44. Unique Identifier : AIDSLINE MED/20391148
- Karrow NA; McCay JA; Brown RD; Musgrove DL; Pettit DA; Munson AE; Germolec DR; White KL Jr; Department of Pharmacology and Toxicology, Virginia Commonwealth; University, Richmond 23298-6013, USA.
- Thalidomide has been shown to have antiinflammatory and, more recently, immunomodulating properties, which are beneficial for the treatment of an ever-increasing list of immune related diseases. Although considerable knowledge regarding thalidomide s antiinflammatory properties has been acquired, relatively little is
- Prolonged allograft survival in anti-CD4 antibody transgenic mice: lack of residual helper T cells compared with other CD4-deficient mice.
- Transplantation. 2000 Jul 15;70(1):168-74. Unique Identifier : AIDSLINE MED/20374249
- Han WR; Zhan Y; Murray-Segal LJ; Brady JL; Lew AM; Mottram PL; University of Melbourne, Department of Surgery, and the Walter; and Eliza Hall Institute for Medical Research, Royal Melbourne; Hospital, Australia.
- BACKGROUND: Investigations of the role of CD4 T lymphocytes in allograft rejection and tolerance have relied on the use of mouse models with a deficiency in CD4 cells. However, in mice treated with depleting monoclonal antibody (mAb) and in MHC class II knockout (KO) mice, there are residual populations of CD4 cells.
- Idiopathic giant esophageal ulcers in a renal transplant patient responsive to steroid therapy.
- Transplantation. 2000 Jul 15;70(1):230-2. Unique Identifier : AIDSLINE MED/20374264
- Farrell JJ; Cosimi AB; Chung RT; Gastrointestinal Unit (Medical Services) Massachusetts General; Hospital, Harvard Medical School, Boston 02114, USA.
- Idiopathic giant esophageal ulcers in immunocompromised patients have been described only in patients with acquired immunodeficiency syndrome. A solitary report of an idiopathic giant esophageal ulcer in an immunocompetent patient exists. We describe a case of idiopathic esophageal ulceration ultimately responsive to
- Neutralization of tumor necrosis factor-alpha action delays but does not prevent lung injury induced by alloreactive T helper 1 cells.
- Transplantation. 2000 Jul 15;70(1):39-43. Unique Identifier : AIDSLINE MED/20374225
- Clark JG; Mandac JB; Dixon AE; Martin PJ; Hackman RC; Madtes DK; Fred Hutchinson Cancer Research Center, Department of Medicine,; University of Washington School of Medicine, Seattle 98109-1024,; USA. jclark@fhcrc.org
- BACKGROUND: Lung injury occurs frequently after allogeneic bone marrow transplantation in association with graft-versus-host disease, an immune response that involves both cellular and cytokine components. In a murine model, we recently showed that cloned alloreactive T helper (Th)1 cells can cause lung injury associa
- Prevalence of HIV infection, sexually transmitted diseases, and hepatitis and related risk behavior in young women living in low-income neighborhoods of northern California.
- West J Med. 2000 Jun;172(6):368-73. Unique Identifier : AIDSLINE MED/20314839
- Ruiz JD; Molitor F; McFarland W; Klausner J; Lemp G; Page-Shafer K; Parikh-Patel A; Morrow S; Sun RK; California Department of Health Services Office of AIDS HIV/AIDS; Epidemiology Branch, Sacramento, CA 94234-7320, USA.; Jruiz1@dhs.ca.gov
- OBJECTIVE: To estimate the prevalence of human immunodeficiency virus (HIV) infection, sexually transmitted diseases, and hepatitis and the associated sexual and drug-using behavior among women residing in low-income neighborhoods in 5 northern California counties. METHODS: From April 4, 1996, to January 6, 1998, wome
- Poor young women need information and empowerment.
- West J Med. 2000 Jun;172(6):373-4. Unique Identifier : AIDSLINE MED/20314840
- May T; Department of Family and Community Medicine, San Francisco; General Hospital, CA 94110, USA. toddmay@itsa.ucsf.edu
- Use of preventive health behaviors by lesbian, bisexual, and heterosexual women: questionnaire survey.
- West J Med. 2000 Jun;172(6):379-84. Unique Identifier : AIDSLINE MED/20314844
- Koh AS; Department of Obstetrics and Gynecology, California Pacific; Medical Center, San Francisco 94118, USA. Audreyace@aol.com
- OBJECTIVES: To determine whether lesbians and bisexual women are less likely than heterosexual women to use preventive health measures. DESIGN: Written, anonymous, self-administered questionnaire. SETTING: 33 physicians offices and community clinics mainly in urban areas of 13 states. PARTICIPANTS: 524 lesbians, 143
- Antifungal resistance in yeast vaginitis.
- Yale J Biol Med. 2000 Jul-Aug;72(4):281-5. Unique Identifier : AIDSLINE MED/20363024
- Dun E; School of Epidemiology and Public Health, Yale University, New; Haven, Connecticut, USA.
- The increased number of vaginal yeast infections in the past few years has been a disturbing trend, and the scientific community has been searching for its etiology. Several theories have been put forth to explain the apparent increase. First, the recent widespread availability
- [The course and therapy of acute hepatitis C viral infection. Is a prevention of its becoming chronic possible?]
- Z Gastroenterol. 2000 May;38(5):387-95. Unique Identifier : AIDSLINE MED/20333332
- Jaeckel E; Manns MP; Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule; Hannover.
- Due to the large number of patients chronically infected with hepatitis C virus and not responding to combination therapy with interferon-alfa 2 and ribavirin new therapeutic regimens are required. Early treatment of the viral infection might improve the response, as s
- [Liver involvement in HIV infection and various parasitic diseases]
- Acta Med Port. 1999 Dec;12(12):345-55. Unique Identifier : AIDSLINE MED/20350358
- Melico-Silvestre A; Da Cunha S; Departamento de Doencas Infecciosas, Hospitais da Universidade; de Coimbra, Faculdade de Medicina de Coimbra.
- During the course of systemic infections, the liver is an organ which is frequently involved. The pathology of the human immunodeficiency virus with all its infections, opportunistic tumours and some parasitoses, such as amebiasis, kala-azar, hydatidosis, schistosomiasis and fascioliasis, evolve into hepatic compromis
- [Kaposi sarcoma associated with HIV infection]
- Acta Med Port. 1999 Dec;12(12):357-66. Unique Identifier : AIDSLINE MED/20350359
- Miranda AM; Gomes MH; Marques R; Abreu C; Tavares AP; Lecour H; Servico de Doencas Infecciosas, Hospital S. Joao, Faculdade de; Medicina do Porto.
- Kaposi s sarcoma is the most common neoplasm in AIDS patients. In a 12-year period, 45 (8%) cases were diagnosed in 552 patients with AIDS. Epidemiological and clinical aspects are reviewed. The disease occurred predominantly in males and homosexuals. In 30 (67%) patients it was the first manifestation of AIDS. Skin a
- [Human immunodeficiency virus type 2 infection]
- Acta Med Port. 1999 Dec;12(12):367-70. Unique Identifier : AIDSLINE MED/20350360
- Mansinho K; Servico de Doencas Infecciosas, Hospital Egas Moniz, Lisboa.
- The isolation of a second retrovirus, HIV-2, led to fears that a second AIDS pandemic, similar in scope and magnitude to that caused by HIV-1, might ensue. However, the peculiar biologic properties of HIV-2, namely the lower transmissibility of this virus through both sexual and vertical routes, contributed to a more
- Polymorph function and cellular immunity in Nigerians with pulmonary tuberculosis.
- Afr J Med Med Sci. 1997 Mar-Jun;26(1-2):23-6. Unique Identifier : AIDSLINE MED/20353778
- Onyemelukwe GC; Gupta R
- CD8(+) T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen.
- Am J Pathol. 2000 Jul;157(1):171-5. Unique Identifier : AIDSLINE +
- Willenbrock K; Roers A; Blohbaum B; Rajewsky K; Hansmann ML; Institute for Pathology, University of Frankfurt, Germany.
- A minor component (about 25%) of lymphocytes in Hodgkin s disease (HD) are CD8(+) T cells. It is unclear whether the presence of these cells reflects an antitumor cytotoxic response. The goal of the present study was to investigate clonal composition and the T cell receptor (TCR) beta repertoire of the CD8(+) T cell p
- Increased MDR1 P-glycoprotein expression in methotrexate resistance: comment on the article by Yudoh et al [letter]
- Arthritis Rheum. 2000 Jul;43(7):1661-2. Unique Identifier : AIDSLINE MED/20358583
- Rahman P; Hefferton D; Robb D
- The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type.
- Unique Identifier : AIDSLINE MED/20391548
- Moser C; Kjaergaard S; Pressler T; Kharazmi A; Koch C; Hoiby N; Department of Clinical Microbiology and Danish Cystic Fibrosis; Centre, University Hospital, Copenhagen, Denmark.
- Most cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa lung infection have a persistent acute type lung inflammation dominated by polymorphonuclear neutrophils (PMN) and a pronounced antibody response against P. aeruginosa. We speculated whether this immune response in CF is of the Th2 type and whether
- Nodular granulomatous Pneumocystis carinii pneumonia in a bone marrow transplant recipient. Case report.
- APMIS. 2000 May;108(5):363-6. Unique Identifier : AIDSLINE MED/20391553
- Leroy X; Copin MC; Ramon P; Jouet JP; Gosselin B; Department of Pathology, CHRU, Lille, France.
- We report a case of nodular granulomatous Pneumocystis carinii pneumonia following bone marrow transplantation. The patient was a 40-year-old man who had undergone bone marrow transplantation for myeloblastic acute leukemia. He presented with fever, dyspnea and bilateral diffuse nodular infiltration of the lungs. Bron
- Spermatozoon as a vehicle for HIV-1 and other viruses: a review.
- Mol Reprod Dev. 2000 Jun;56(2 Suppl):238-42. Unique Identifier : AIDSLINE MED/20283117
- Piomboni P; Baccetti B; Institute of General Biology, University and Center for the Study; of Germinal Cells, CNR, Siena, Italy.
- Genetic subtypes of HIV type 1 in Republic of Congo.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):613-9. Unique Identifier : AIDSLINE GENBANK/AF119219
- Bikandou B; Takehisa J; Mboudjeka I; Ido E; Kuwata T; Miyazaki Y; Moriyama H; Harada Y; Taniguchi Y; Ichimura H; Ikeda M; Ndolo PJ; Nzoukoudi MY; M'Vouenze R; M'Pandi M; Parra HJ; M'Pele P; Hayami M; Laboratory of Viral Pathogenesis, Institute for Virus Research; Kyoto University, Japan.
- To assess the molecular epidemiology of HIV-1 in Republic of Congo (Congo), we investigated 29 HIV-1s obtained from 82 Congolese AIDS and ARC patients in 1996 and 1997. Part of the env region including the V3 loop was phylogenetically analyzed. The genotypes observed were varied: of 29 specimens, 12 (41 %) were subtyp
- An improved algorithm for determining HIV type 1 subtypes in a primary laboratory in Uganda.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):621-5. Unique Identifier : AIDSLINE MED/20250534
- Kaleebu P; Yirrell D; French N; Lyagoba F; Rutebemberwa A; Cheingsong-Popov R; Gilks C; Biryahwaho B; Weber J; Whitworth J; Medical Research Council Programme on AIDS in Uganda, Uganda; Virus Research Institute, Entebbe. mrc@starcom.co.ug
- A pilot study was undertaken with the objective of developing a simple, economical, and efficient algorithm through which to subtype HIV-1 in a large epidemiological cohort study in Uganda . A peptide enzyme immunoassay (PEIA) employing both V3 and gp41 regions and a heteroduplex mo
- Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):627-34. Unique Identifier : AIDSLINE MED/20250535
- Cabrera C; Gutierrez A; Blanco J; Barretina J; Litovchick A; Lapidot A; Evdokimov AG; Clotet B; Este JA; Institut de Recerca de la SIDA-Caixa (irsiCaixa), Retrovirology; Laboratory, Hospital Universitari Germans Trias i Pujol,; Badalona, Spain.
- Conjugates of L-arginine with aminoglycosides have already been described as potent in vitro inhibitors of the HIV-1 Tat-trans-activation responsive element interaction. The polycationic nature of these agents leads us to suggest that they may be active against HIV-1 replication by inhibiting earlier stages of the vir
- Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):635-44. Unique Identifier : AIDSLINE MED/20250536
- Gerschenson M; Erhart SW; Paik CY; St Claire MC; Nagashima K; Skopets B; Harbaugh SW; Harbaugh JW; Quan W; Poirier MC; Division of Basic Sciences, National Cancer Institute, NIH,; Bethesda, Maryland 20892-4255, USA. gerschem@exchange.nih.gov
- 3 -azido-3 -deoxythymidine ( AZT ) is given to pregnant women positive for the human immunodeficiency virus type 1 (HIV-1) to reduce maternal-fetal viral transmission. To explore fetal mitochondrial consequences of this exposure, pregnant Erythrocebus p
- Both serum HIV type 1 RNA levels and CD4+ lymphocyte counts predict clinical outcome in HIV type 1-infected subjects with 200 to 500 CD4+ cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):645-53. Unique Identifier : AIDSLINE MED/20250537
- Kim S; Hughes MD; Hammer SM; Jackson JB; DeGruttola V; Katzenstein DA; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.
- To evaluate HIV-1 RNA and CD4+ cell responses to therapy as predictors of clinical progression and to evaluate levels and trends of these markers prior to clinical failure, HIV-1 RNA measurements were retrospectively obtained on subjects who progressed to AIDS or death and a random sample of subjects who did not. Samp
- AIDSVAX (MN) in Bangkok injecting drug users: a report on safety and immunogenicity, including macrophage-tropic virus neutralization.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):655-63. Unique Identifier : AIDSLINE MED/20250538
- Migasena S; Suntharasamai P; Pitisuttithum P; Kitayaporn D; Wasi C; Huang W; Vanichseni S; Koompong C; Kaewkungwal J; Raktham S; Ippolito T; Hanson C; Gregory T; Heyward WL; Berman P; Francis D; Vaccine Trial Center, Faculty of Tropical Medicine, Mahidol; University, Bangkok, Thailand.
- A randomized, double-blind, placebo-controlled phase I/II study of AIDSVAX (MN) was conducted among injecting drug users in Bangkok, Thailand . Four doses of vaccine (300 microg of MN-rgp120 in alum) or placebo (alum) were given at study entry and at 1, 6, and 12 months. The objec
- Real-time polymerase chain reaction assay for cell-associated HTLV type I DNA viral load.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):665-75. Unique Identifier : AIDSLINE MED/20250539
- Miley WJ; Suryanarayana K; Manns A; Kubota R; Jacobson S; Lifson JD; Waters D; Human Retrovirus Section, SAIC Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center,; Maryland 21702, USA.
- We have developed a quantitative real-time PCR assay for HTLV-I DNA. This assay approach uses real-time monitoring of fluorescent signal generation as a consequence of Taq-mediated amplification of specific target sequences to allow real-time kinetic analysis of amplicon production. This kinetic approach yields excell
- Feline immunodeficiency virus clade C mucosal transmission and disease courses.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):677-88. Unique Identifier : AIDSLINE MED/20250540
- Obert LA; Hoover EA; Department of Pathology, College of Veterinary Medicine and; Biomedical Sciences, Colorado State University, Fort Collins; 80523, USA.
- The transmissibility and pathogenicity of a clade C feline immunodeficiency virus (FIV-C) was examined via the oral-nasal, vaginal, or rectal mucosa. FIV-C was transmissible by all three mucosal routes. Vaginal transmission was most efficient (100%), oral exposure resulted in a 80% infection rate, and rectal transmiss
- Early activation and proliferation of T cells in simian immunodeficiency virus-infected rhesus monkeys.
- AIDS Res Hum Retroviruses. 2000 May 1;16(7):689-97. Unique Identifier : AIDSLINE MED/20250541
- Sopper S; Sauer U; Muller JG; Stahl-Hennig C; ter Meulen V; Institut fur Virologie und Immunobiologic, Universitat; Wurzburg, Germany. sopper@vim.uni-wuerzburg.de
- To longitudinally determine T cell activation and turnover in early simian immunodeficiency virus (SIV) infection of macaques, immunological and virological parameters were monitored in 10 SIV-infected animals starting before infection until 40 weeks postinfection (wpi). Lymphocyte subsets in blood and lymph nodes (LN
- Only a small fraction of purified hepatitis C RNA-dependent RNA polymerase is catalytically competent: implications for viral replication and in vitro assays.
- Biochemistry. 2000 Jul 18;39(28):8243-9. Unique Identifier : AIDSLINE MED/20349350
- Carroll SS; Sardana V; Yang Z; Jacobs AR; Mizenko C; Hall D; Hill L; Zugay-Murphy J; Kuo LC; Department of Antiviral Research, Merck Research Labs, West; Point, Pennsylvania, 19486, USA.
- The enzymatic activity of a C-terminally truncated form of the RNA-dependent RNA polymerase, termed NS5B(Delta21), of the hepatitis C virus (strain BK) has been investigated using both homopolymeric and heteropolymeric RNA templates. Incorporation of nucleotides into a heteropolymeric RNA template as catalyzed by NS5B
- Triplex formation by psoralen-conjugated chimeric oligonucleoside methylphosphonates.
- Biochemistry. 2000 Jul 25;39(29):8683-91. Unique Identifier : AIDSLINE MED/20374545
- Cassidy RA; Kondo NS; Miller PS; Department of Biochemistry and Molecular Biology, School of; Hygiene and Public Health, Johns Hopkins University, Baltimore,; Maryland 21205, USA.
- Interactions between nuclease-resistant, 5 -psoralen-conjugated, chimeric methylphosphonate oligodeoxyribo- or oligo-2 -O-methylribo-triplex-forming oligomers (TFOs) and a purine tract found in the envelope gene of HIV proviral DNA (env-DNA) were investigated by gel mobility shift assays or by photo-cross-linking expe
- Infection of bovine immunodeficiency virus and bovine leukemia virus in water buffalo and cattle populations in Pakistan.
- J Vet Med Sci. 2000 Mar;62(3):329-31. Unique Identifier : AIDSLINE MED/20231378
- Meas S; Seto J; Sugimoto C; Bakhsh M; Riaz M; Sato T; Naeem K; Ohashi K; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Sapporo, Japan.
- A survey of antibodies to bovine immunodeficiency virus (BIV) known as bovine lentivirus and bovine leukemia virus (BLV) was conducted with samples from water buffalo and cattle populations in Pakistan . A total of 370 water buffaloes and 76 cattle were tested, and 10.3% and 15.8%
- International committee unveils initial plans to explore long-term use of HIV treatment [news]
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):105-6. Unique Identifier : AIDSLINE MED/20286060
- Heterosexual prevention: the key to averting HIV orphanhood [editorial]
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):11-2. Unique Identifier : AIDSLINE MED/20286050
- Porche DJ
- Predictors of perception of cognitive functioning in HIV/AIDS.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):19-26. Unique Identifier : AIDSLINE MED/20286051
- Corless IB; Bakken S; Nicholas PK; Holzemer WL; McGibbon CA; Inouye J; Nokes KM; Turner JG; Powell-Cope GM; Brown MA; Portillo CJ; MGH Institute of Health Professions, Boston, USA.
- This is a descriptive, correlational study of the predictors of perceived cognitive functioning. The convenience sample of 728 nonhospitalized persons receiving health care for HIV/AIDS was recruited from seven sites in the United States . All measures were self-reported. Self-perceptio
- Sources of occupational stress and coping strategies among nurses working in AIDS care.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):31-7. Unique Identifier : AIDSLINE MED/20286052
- Kalichman SC; Gueritault-Chalvin V; Demi A; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Milwaukee 53226, USA. sethk@mcw.edu
- Nurses working in AIDS care experience high rates of occupational stress and therefore are vulnerable to emotional exhaustion and occupational burnout. This study surveyed 499 members of the Association of Nurses in AIDS Care regarding their work-related stress experiences and coping strategies for managing stress. Qu
- Identifying HIV/AIDS research priorities for the next millennium: a Delphi study with nurses in AIDS care.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):42-52. Unique Identifier : AIDSLINE MED/20286053
- Sowell RL; Department of Administrative and Clinical Nursing, University of; South Carolina, Columbia, USA.
- The purpose of this study was to identify HIV/AIDS research priorities for the next millennium from the perspective of nurses in AIDS care. The study used a three-round Delphi technique, with study participants (the panel of experts) selected from the membership of the Association of Nurses in AIDS Care. In the first
- Active client participation: an examination of self-empowerment in HIV/AIDS case management with women.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):59-68. Unique Identifier : AIDSLINE MED/20286054
- Flynn MB; McKeever JL; Spada T; Gordon-Garofalo V; Veterans Affairs Medical Center, New Orleans, Louisiana, USA.
- Case management has become increasingly popular as a means to alleviate the difficulties associated with accessing health care and social services. However, little information exists regarding models of case management specifically intended for work with HIV-positive women. This article explores the practices currentl
- Developing culture-specific interventions for Latinas to reduce HIV high-risk behaviors.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):70-6. Unique Identifier : AIDSLINE MED/20286055
- Russell LD; Alexander MK; Corbo KF; University of Massachusetts Worcester Graduate School of Nursing,; USA.
- Latina women are among the fastest-growing segments of the U.S. population to become infected with HIV. Health care providers must use culture-specific HIV prevention strategies and must address cultural roles and values of the Latin community to empower Latinas to reduce high-risk behaviors. Some Latinas adhere to th
- The lived experience of grieving for persons living with HIV who have used injection drugs.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):82-92. Unique Identifier : AIDSLINE MED/20286056
- Cody WK; Department of Family and Community Nursing, University of North; Carolina, Charlotte, USA.
- Parse s research method was used to investigate the lived experience of grieving for 10 persons self-identified as HIV-positive injection drug users. These individuals compose an understudied and poorly understood population, and their grief experiences have rarely been documented. The losses grieved by persons living
- Political activity: a nursing intervention.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):93-4. Unique Identifier : AIDSLINE MED/20286057
- Konkle-Parker DJ; University of Mississippi Medical Center School of Nursing,; Division of Infectious Diseases, USA.
- Efavirenz.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):95-8. Unique Identifier : AIDSLINE MED/20286058
- Porche DJ; Louisiana State University Health Sciences Center School of; Nursing, USA.
- Secondary analysis of qualitative data: a means of collaboration in HIV-related research.
- J Assoc Nurses AIDS Care. 2000 May-Jun;11(3):99-104. Unique Identifier : AIDSLINE MED/20286059
- Santacroce SJ; Deatrick JA; Ledlie SW
- A survey of the use of post-exposure prophylaxis for occupational exposure to human immunodeficiency virus.
- Occup Med (Lond). 2000 Apr;50(3):164-6. Unique Identifier : AIDSLINE MED/20370059
- Grime PR; Risi LJ; Carruthers JR; Department of Occupational Health & Safety, King's College; Hospital, London, UK.
- The objective of this study was to review the appropriateness of the use of post-HIV exposure prophylaxis for incidents involving occupational exposure to body fluids. The design was a retrospective analysis of the 32 incidents for which at least one dose of post-exposure prophylaxis was given, reported to the occupat
- Mortality among males with hemophilia: relations with source of medical care. The Hemophilia Surveillance System Project Investigators.
- Unique Identifier : AIDSLINE MED/20346889
- Soucie JM; Nuss R; Evatt B; Abdelhak A; Cowan L; Hill H; Kolakoski M; Wilber N
- Although persons with hemophilia are known to be at increased risk of death, no studies have examined the source of medical care and other personal characteristics for associations with mortality. To determine death rates and to identify causes of death and predictors of mortality, we studied a cohort comprised of all
- Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.
- Blood. 2000 Jul 15;96(2):467-74. Unique Identifier : AIDSLINE MED/20346893
- Walker RE; Bechtel CM; Natarajan V; Baseler M; Hege KM; Metcalf JA; Stevens R; Hazen A; Blaese RM; Chen CC; Leitman SF; Palensky J; Wittes J; Davey RT Jr; Falloon J; Polis MA; Kovacs JA; Broad DF; Levine BL; Roberts MR; Masur H; Lane HC; Clinical and Molecular Retrovirology Section, Laboratory of; Immunoregulation, National Institute of Allergy and Infectious; Diseases, Clinical Gene Therapy Branch, National Human Genome; Research Institute, National Institutes of Health, Bethesda, MD,; USA.
- To study human immunodeficiency virus (HIV)-specific cellular immunity in vivo, we transferred syngeneic lymphocytes after ex vivo expansion and transduction with a chimeric receptor gene (CD4/CD3-zeta) between identical twins discordant for HIV infection. Single and multiple infusions of 10(10) genetically modified C
- Stable expression of Epstein-Barr virus BZLF-1-encoded ZEBRA protein activates p53-dependent transcription in human Jurkat T-lymphoblastoid cells.
- Blood. 2000 Jul 15;96(2):625-34. Unique Identifier : AIDSLINE MED/20346913
- Dreyfus DH; Nagasawa M; Kelleher CA; Gelfand EW; Division of Basic Sciences, Department of Pediatrics, National; Jewish Medical and Research Center, Denver, CO 80206, USA.
- Interaction between viral proteins and tumor suppressor p53 is a common mechanism of viral pathogenesis. The Epstein-Barr virus (EBV) BZLF-1 ORF-encoded ZEBRA protein (also denoted EB1, Z, Zta) binds to p53 in vitro and has been associated with the altered transcription of p53-regulated genes in B lymphocytes and epit
- Altered lymphoid development in mice deficient for the mAF4 proto-oncogene.
- Blood. 2000 Jul 15;96(2):705-10. Unique Identifier : AIDSLINE MED/20346924
- Isnard P; Core N; Naquet P; Djabali M; Centre d'immunologie INSERM-CNRS de Marseille Luminy, Marseille; Cedex 9, France.
- Some chromosomal translocations in acute leukemias involve the fusion of the trithorax-related protein Mll (also called HRX, All1, Htrx,) with a variety of heterologous proteins. In acute lymphoblastic leukemia associated with the t(4;11)(q21;q23) translocation, the 4q21 gene that fuses with Mll is AF4. To gain insigh
- Prolonged CD4 depletion after sequential autologous peripheral blood progenitor cell infusions in children and young adults.
- Blood. 2000 Jul 15;96(2):754-62. Unique Identifier : AIDSLINE MED/20346931
- Mackall CL; Stein D; Fleisher TA; Brown MR; Hakim FT; Bare CV; Leitman SF; Read EJ; Carter CS; Wexler LH; Gress RE; Pediatric Oncology Branch, Medicine Branch, Experimental; Immunology Branch, National Cancer Institute and Department of; Transfusion Medicine, Clinical Center, National Institutes of; Health, Bethesda, MD, 20892 USA. cm35c@nih.gov
- Administration of mobilized peripheral blood progenitor cells (PBPCs) after high-dose chemotherapy rapidly restores multilineage hematopoiesis, but the ability of such products to restore lymphocyte populations remains unclear. In this report, we evaluated immune reconstitution in a series of patients treated with seq
- A competition model for viral inhibition of host cell proliferation.
- Math Biosci. 2000 Jul;166(1):69-84. Unique Identifier : AIDSLINE MED/20340860
- Holtea S; Emerman M; Division of Human Biology, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109, USA. sarah@hivnet.fhcrc.org
- Some viruses encode proteins that promote cell proliferation while others, such as the human immunodeficiency virus (HIV), encode proteins that prevent cell division. It has been hypothesized that the selective advantage determining which strategy evolves depends on the ability of the virus to induce a cellular enviro
- Mbeki dismisses "Durban declaration" [news]
- BMJ. 2000 Jul 8;321(7253):67. Unique Identifier : AIDSLINE MED/20340893
- Sidley P
- UN says up to half the teenagers in Africa will die of AIDS [news]
- BMJ. 2000 Jul 8;321(7253):67. Unique Identifier : AIDSLINE MED/20340892
- Gottlieb S
- Prevalence of antibodies to hepatitis B, hepatitis C, and HIV and risk factors in Irish prisoners: results of a national cross sectional survey.
- Unique Identifier : AIDSLINE MED/20340909
- Allwright S; Bradley F; Long J; Barry J; Thornton L; Parry JV
- OBJECTIVES: To determine the prevalence of antibodies to hepatitis B core antigen, hepatitis C virus, and HIV in the prison population of the Republic of Ireland and to examine risk factors for infection. DESIGN: Cross sectional, an
- "War of liberation" needed to fight AIDS [news]
- BMJ. 2000 Jul 15;321(7254):131. Unique Identifier : AIDSLINE MED/20353326
- Kmietowicz Z
- Judge attacks South African government's response to AIDS [news]
- BMJ. 2000 Jul 15;321(7254):131. Unique Identifier : AIDSLINE MED/20353325
- Ferriman A
- Four-year study of abdominal ultrasound in 900 Central African adults with AIDS referred for diagnostic imaging.
- Abdom Imaging. 2000 May-Jun;25(3):290-6. Unique Identifier : AIDSLINE MED/20280960
- Tshibwabwa ET; Mwaba P; Bogle-Taylor J; Zumla A; Department of Radiology, Diagnostic Imaging, McMaster University,; Faculty of Health Sciences, West Hamilton, Canada.
- BACKGROUND: In the majority of sub-Saharan African countries, the absence of computed tomography facilities makes abdominal ultrasound (US) an alternative diagnostic tool in the clinical investigation of infectious and noninfectious complications of human immunodeficiency virus (HIV)-infected individuals. We studied t
- [Clinical profile of cytomegalovirus (CMV) enterocolitis in acquired immunodeficiency syndrome]
- Unique Identifier : AIDSLINE MED/20233760
- De Lima DB; Fernandes O; Gomes VR; Da Silva EJ; De Pinho PR; De Paiva DD
- OBJECTIVE: To determine the clinical profile of CMV colitis in AIDS patients, comparing clinical, endoscopic parameters and survival time between 2 groups of AIDS patients having chronic diarrhea. Group A being CMV colitis and group B without CMV colitis. METHOD
- A human B-lineage dendritic cell line, HBM-noda and its potential role in human T-cell leukemia/lymphoma virus type I infection.
- Pathol Int. 2000 Apr;50(4):280-90. Unique Identifier : AIDSLINE MED/20307457
- Nagasaki M; Morikawa S; Torii I; Zhang J; Morikawa K; Department of Pathology, First Unit, Shimane Medical University,; Izumo, Shimane, Japan. makoto-n@sx.miracle.ne.jp
- An Epstein-Barr virus-transformed B-cell line, HBM-Noda (Noda), that has a dendritic morphology as well as several characteristic features of dendritic cells (DC) has been established. We therefore refer to Noda as B-lineage DC. Although human T-cell leukemia/lymphoma virus type I (HTLV-I) exhibit substantial cellular
- Reactive follicular hyperplasia in the lymph node lesions from
- Unique Identifier : AIDSLINE MED/20307460
- Spontaneously regressed Kaposi's sarcoma and human herpesvirus 8 infection in a human immunodeficiency virus-negative patient.
- Pathol Int. 2000 Apr;50(4):340-6. Unique Identifier : AIDSLINE MED/20307466
- Kondo Y; Izumi T; Yanagawa T; Kanda H; Katano H; Sata T; Department of Pathology, Dermatology and Internal Medicine,; Nerima General Hospital, Tokyo, Japan. info@nerima-hosp.or.jp
- Kaposi s sarcoma occurring in a 78-year-old woman, with the absence of the human immunodeficiency virus infection, was correctly diagnosed by immunohistochemistry using anti-human herpesvirus 8 (HHV8) antibody (PA1-73N) for the first time. The patient suffered from chronic respiratory failure and was treated with a lo
- Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system.
- Eur J Neurosci. 2000 Jun;12(6):1857-66. Unique Identifier : AIDSLINE MED/20345437
- Gleichmann M; Gillen C; Czardybon M; Bosse F; Greiner-Petter R; Auer J; Muller HW; Molecular Neurobiology Laboratory, Department of Neurology,; andBiomedical Research Center, University of Dusseldorf,; Moorenstrasse 5, D-40225 Dusseldorf, Germany.
- The cytokines SDF-1alpha and -1beta are two alternatively spliced variants of the CXC (alpha) chemokines that are highly conserved among species. SDF-1alpha was shown to function as a B-cell maturation factor, a ligand for the CXCR4 (LESTR/fusin) chemokine receptor, thereby inhibiting replication of T cell-tropic HIV-
- Reliability of self-reports about sexual risk behavior for HIV among homeless men with severe mental illness.
- Psychiatr Serv. 2000 Jun;51(6):814-6. Unique Identifier : AIDSLINE MED/20287786
- Sohler N; Colson PW; Meyer-Bahlburg HF; Susser E; Division of Epidemiology, Columbia University, New York, NY; 10032, USA. nls9@columbia.edu
- The reliability of self-reports of sexual behaviors related to HIV transmission was examined in a study of homeless men with severe mental illness. Thirty-nine patients of a New York City shelter psychiatric program were interviewed about their sexual behaviors in the past six months. The same interview was administer
- The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity [editorial; comment]
- Clin Exp Allergy. 2000 Jun;30(6):751-2. Unique Identifier : AIDSLINE MED/20308135
- Shakib F; Gough L
- Simian immunodeficiency virus mac251 infection of astrocytes.
- J Neurovirol. 2000 Jun;6(3):173-86. Unique Identifier : AIDSLINE MED/20342589
- Guillemin G; Croitoru J; Le Grand RL; Franck-Duchenne M; Dormont D; Boussin FD; CEA, Service de Neurovirologie, DSV/DRM/SSA/IPSC, 60 - 80, avenue; de la Division Leclerc, BP 6, 92265 Fontenay-aux-Roses cedex,; France.
- Human immunodeficiency virus type 1 (HIV-1) infection of astrocytes has been demonstrated in the brains of patients with AIDS dementia complex (ADC) and may play an important role in neuropathological pathways of HIV-related encephalopathy. SIVmac-infected monkeys develop an acquir
- Relationship between viral load in blood, cerebrospinal fluid, brain tissue and isolated microglia with neurological disease in macaques infected with different strains of SIV.
- J Neurovirol. 2000 Jun;6(3):187-201. Unique Identifier : AIDSLINE MED/20342590
- Demuth M; Czub S; Sauer U; Koutsilieri E; Haaft P; Heeney J; Stahl-Hennig C; ter Meulen V; Sopper S; Institut fur Virologie und Immunbiologie,; Julius-Maximilians-Universitat, Versbacherstrabetae 7, D-97078; Wurzburg, Germany.
- The role of the viral burden in the brain for the pathogenesis of human immunodeficiency virus-associated neurological disorders is still unclear. To address this issue, we have quantified the viral load in plasma, cerebrospinal fluid (CSF) and brain tissue of macaques infected with simian immunodeficiency virus (SIV)
- Effects of extracellular human immunodeficiency virus type 1 vpr protein in primary rat cortical cell cultures.
- J Neurovirol. 2000 Jun;6(3):202-20. Unique Identifier : AIDSLINE MED/20342591
- Huang MB; Weeks O; Zhao LJ; Saltarelli M; Bond VC; Department of Biochemistry, Morehouse School of Medicine,; Atlanta, Georgia, GA 30310, USA.
- Recent evidence suggests that HIV-1 Vpr exists in soluble form in the serum and cerebrospinal fluid (CSF). Further, its abundance in the bloodstream, and the CSF, and its activity on other cell types suggest that it could have an effect on brain activity. Using mixed embryonic rat brain cultures as a model to examine
- Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with progressive multifocal leukoencephalopathy.
- J Neurovirol. 2000 Jun;6(3):221-8. Unique Identifier : AIDSLINE MED/20342592
- Valle LD; Croul S; Morgello S; Amini S; Rappaport J; Khalili K; Center for Neurovirology and Cancer Biology, College of Science; and Technology, Temple University, Philadelphia, PA 19122, USA.
- HIV-1 infection can lead to severe central nervous system (CNS) clinical syndromes in more than 50% of HIV-1 positive individuals. Progressive multifocal leukoencephalopathy (PML) is the frequent opportunistic infection of the CNS which is seen in as high as 5% of AIDS patients. Results from previous cell culture stud
- Cerebrovascular disease in young, HIV-infected, black Africans in the KwaZulu Natal province of South Africa.
- J Neurovirol. 2000 Jun;6(3):229-36. Unique Identifier : AIDSLINE MED/20342593
- Hoffmann M; Berger JR; Nath A; Rayens M; Department of Neurology, University of Kentucky, Lexington,; Kentucky, USA.
- The objective of this study was to elucidate the mechanisms of an ischemic stroke in a human immunodeficiency virus, type 1 (HIV)-infected population. Several clinical and autopsy studies have suggested an increased incidence of strokes in HIV-infected persons. These studies have been performed on diverse populations
- HIV and the nervous system: emerging issues. Proceedings of a symposium. Washington DC, USA. April 14-16, 1999.
- J Neurovirol. 2000 May;6 Suppl 1:S1-128. Unique Identifier : AIDSLINE MED/20332436
- Neuronal damage - recent issues and implications for therapy.
- J Neurovirol. 2000 May;6 Suppl 1:S103-5. Unique Identifier : AIDSLINE MED/20332450
- Everall IP; Section of Experimental Neuropathology and Psychiatry,; Departments of Neuropathology and Psychological Medicine, 1; Windsor Walk, Institute of Psychiatry, London, SE5 8AF, UK.
- The spectrum of structural damage in the brain associated with HIV is now more fully understood. Such changes include inflammatory disorders (such as HIV encephalitis, leukoencephalopathy, and diffuse poliodystrophy), dendritic and synaptic damage, and neuronal loss. However, the relationship between neuronal damage a
- HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia.
- J Neurovirol. 2000 May;6 Suppl 1:S14-23. Unique Identifier : AIDSLINE MED/20332438
- Xiong H; Zeng YC; Lewis T; Zheng J; Persidsky Y; Gendelman HE; The Center for Neurovirology and Neurodegenerative Disorders,; University of Nebraska Medical Center, Omaha, Nebraska, NE; 68198-5215 USA.
- Viral and cellular products from HIV-1-infected and/or immune competent mononuclear phagocytes (MP) (brain macrophages and microglia) affect neuronal function during HIV-1-associated dementia (HAD). Neurotoxic MP factors include, but are not limited to, pro-inflammatory cytokines,
- Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis.
- J Neurovirol. 2000 May;6 Suppl 1:S24-32. Unique Identifier : AIDSLINE MED/20332439
- Gabuzda D; Wang J; Department of Cancer Immunology & AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts, MA 02115, USA.
- Several chemokine receptors are used as coreceptors for HIV-1 entry in the central nervous system (CNS). CCR5 is the major coreceptor together with CD4 for HIV-1 infection of microglia, the major target cells for HIV-1 infection in the CNS. CXCR4 and CCR3 are also expressed on microglia and can mediate infection by ce
- Neurologic disease in injection drug users: therapeutic issues.
- J Neurovirol. 2000 May;6 Suppl 1:S33-7. Unique Identifier : AIDSLINE MED/20332440
- Royal W 3rd; Johns Hopkins University School of Medicine, 600 North Wolfe; Street, Baltimore, Maryland, MD 21287, USA.
- Illicit drug use may cause nervous system impairment as a result of direct and indirect effects on the integrity and function of nervous system tissue and, potentially, through immune effects. HIV-1 infection poses an additional risk of impairment, and this risk may be decreased as a result of antiretroviral drug trea
- Neuronal apoptosis in human immunodeficiency virus infection.
- J Neurovirol. 2000 May;6 Suppl 1:S38-43. Unique Identifier : AIDSLINE MED/20332441
- Gray F; Adle-Biassette H; Brion F; Ereau T; le Maner I; Levy V; Corcket G; Laboratoire de Neuropathologie, Hopital Raymond Poincare -; Faculte de Medecine Paris-Ouest, 104 boulevard Raymond; Poincare, F-92380 Garches, France.
- Neuronal apoptosis has been shown to occur in HIV infection by a number of in vivo and in vitro studies, however, the cause of neuronal damage in AIDS is still unclear and its relationships with the cognitive disorders characteristic of HIV dementia remain a matter of debate. In th
- Characterization of cultured microglia that can be infected by HIV-1.
- J Neurovirol. 2000 May;6 Suppl 1:S53-60. Unique Identifier : AIDSLINE MED/20332443
- Albright AV; Shieh JT; O'Connor MJ; Gonzalez-Scarano F; Department of Neurology, University of Pennsylvania School of; Medicine, Philadelphia, Pennsylvania, PA 19104-6146, USA.
- Parenchymal microglia are targets of HIV infection. We, as well as others, have used in vitro microglia culture systems to study the tropism and replication of HIV. Characterization of perivascular and parenchymal microglia surface markers in vivo, in vitro, and ex vivo, has led to the understanding that these cell po
- Functional expression of the seven-transmembrane HIV-1 co-receptor APJ in neural cells.
- J Neurovirol. 2000 May;6 Suppl 1:S61-9. Unique Identifier : AIDSLINE MED/20332444
- Choe W; Albright A; Sulcove J; Jaffer S; Hesselgesser J; Lavi E; Crino P; Kolson DL; Department of Neurology, University of Pennsylvania,; Philadelphia, Pennsylvania, PA 19104, USA.
- APJ is a recently described seven-transmembrane (7TM) receptor that is abundantly expressed in the central nervous system (CNS). This suggests an important role for APJ in neural development and/or function, but neither its cellular distribution nor its function have been defined. APJ can also serve as a co-receptor w
- Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain.
- J Neurovirol. 2000 May;6 Suppl 1:S70-81. Unique Identifier : AIDSLINE MED/20332445
- Liu Y; Tang XP; McArthur JC; Scott J; Gartner S; Department of Neurology, The Johns Hopkins University, Baltimore,; Maryland, MA 21287, USA.
- Towards understanding the pathogenesis of HIV dementia , we molecularly cloned and sequenced human immundeficiency virus type 1 (HIV-1) gp160 genes from uncultured post-mortem tissues collected from a patient with HIV dementia. Sequences from bone marrow, lymph node, lung, and four
- Current approaches to treatment for HIV-1 infection.
- J Neurovirol. 2000 May;6 Suppl 1:S8-S13. Unique Identifier : AIDSLINE MED/20332437
- Powderly WG; Division of Infectious Diseases, Washington University School of; Medicine, Campus Box 8051, St. Louis, Missouri, MO 63110, USA.
- The last 3 years have seen a dramatic fall in mortality and morbidity from HIV infection. Four factors have contributed to this: an improved understanding of the pathogenesis of HIV infection; the availability of tests that could measure plasma viral burden; the development of new and more powerful drugs such as the p
- Mechanisms of leukocyte trafficking into the CNS.
- J Neurovirol. 2000 May;6 Suppl 1:S82-5. Unique Identifier : AIDSLINE MED/20332446
- Wu DT; Woodman SE; Weiss JM; McManus CM; D'Aversa TG; Hesselgesser J; Major EO; Nath A; Berman JW; Department of Pathology, Albert Einstein College of Medicine,; Bronx, New York, NY 10461, USA.
- HIV-1 encephalitis occurs in up to one-third of HIV-1-infected individuals. The mechanisms through which this pathology develops are thought to involve viral passage across the blood-brain barrier (BBB), as well as entry of HIV-infected and/or uninfected inflammatory cells into the central nervous system (CNS). Viral
- Stages of restricted HIV-1 infection in astrocyte cultures derived from human fetal brain tissue.
- J Neurovirol. 2000 May;6 Suppl 1:S90-4. Unique Identifier : AIDSLINE MED/20332448
- Messam CA; Major EO; Laboratory of Molecular Medicine and Neuroscience, National; Institute of Neurological Disorders and Stroke, National; Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, MD; 20892, USA.
- The predominant cell types infected by HIV-1 in AIDS associated encephalopathy are cells of the macrophage/microglial lineage. There has been consistent evidence, however, that astrocytes also become infected although not at the same frequency or level of multiplication as microglial cells. HIV-1 antigens and/or nucle
- Molecular analysis of cerebrospinal fluid: potential for the study of HIV-1 infection of the central nervous system.
- J Neurovirol. 2000 May;6 Suppl 1:S95-S102. Unique Identifier : AIDSLINE MED/20332449
- Cinque P; Bestetti A; Morelli P; Presi S; Division of Infectious Diseases, San Raffaele Hospital, Via; Stamira d'Ancona 20, 20127 Milan, Italy.
- The molecular analysis of cerebrospinal fluid (CSF) provides an inestimable tool for the study of HIV infection of the central nervous system (CNS). Current nucleic acid amplification techniques enable the measurement of CSF HIV-1 RNA levels which can be predictive of HIV-associated neurological damage. CSF HIV-1 RNA
- Home HIV testing - a possibility? [news]
- Mol Med Today. 2000 Jul;6(7):259-60. Unique Identifier : AIDSLINE MED/20319143
- Dorrell S
- The role of nonhuman primate models in AIDS vaccine development.
- Mol Med Today. 2000 Jul;6(7):267-70. Unique Identifier : AIDSLINE MED/20319145
- Johnston MI; National Institute of Allergy and Infectious Diseases, Bethesda,; MD 20892-7628, USA. pj7p@nih.gov
- Although animal models have been useful in guiding vaccine development, HIV/AIDS models have not yielded a clear correlate of immunity nor given consistent results on the potential efficacy of various vaccine approaches. Further development and improved uniformity in the use of animal models would maximize their poten
- Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.
- Cancer Res. 2000 Jul 1;60(13):3542-9. Unique Identifier : AIDSLINE MED/20365422
- Hoffmann TK; Meidenbauer N; Dworacki G; Kanaya H; Whiteside TL; University of Pittsburgh Cancer Institute, University of; Pittsburgh School of Medicine, Pennsylvania 15213, USA.
- It has been suggested that dendritic cells (DCs) are capable of ingesting apoptotic tumor cells (ATCs) and presenting tumor-associated antigens to immune cells. We evaluated the potential of human DCs, which have ingested ATCs, to serve as a source of antigenic epitopes for presentation to T cells specific for PCI-13,
- Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.
- Cancer Res. 2000 Jul 1;60(13):3559-68. Unique Identifier : AIDSLINE MED/20365424
- Mortarini R; Borri A; Tragni G; Bersani I; Vegetti C; Bajetta E; Pilotti S; Cerundolo V; Anichini A; Department of Experimental Oncology, Istituto Nazionale per lo; Studio e la Cura dei Tumori, Milan, Italy.
- Systemic effects on T-cell-mediated antitumor immunity, on expression of T-cell adhesion/homing receptors, and on the promotion of T-cell infiltration of neoplastic tissue may represent key steps for the efficacy of immunological therapies of cancer. In this study, we investigated whether these processes can be promot
- [The serum levels of soluble interleukin-2 receptor in patients with malignant lymphocytic proliferative disorders]
- Chung Hua Hsueh Yeh Hsueh Tsa Chih. 1998 Feb;19(2):82-4. Unique Identifier : AIDSLINE MED/20376522
- Xu J; Wang B; Zhongshan Hospital, Shanghai Medical University.
- OBJECTIVE: To explore the changes of serum levels of soluble interleukin-2 receptor (sIL-2R) in lymphocytic malignancies and its clinical implication. METHODS: The serum levels of sIL-2R were measured in 60 cases of patients with various malignant lymphocytic proliferative disorders by using ELISA method. At the same
- Hodgkin's disease related Kaposi's sarcoma in a non HIV infected male patient: a case report and review of the literature on a rare condition.
- Eur J Med Res. 2000 Jul 19;5(7):311-7. Unique Identifier : AIDSLINE MED/20363999
- Jung CP; Gurtler L; Goebel FD; Medizinische Poliklinik/Klinikum Innenstadt, Ludwig-Maximilians-; University of Munich, Germany. jungc@mskcc.org.
- A higher incidence of coexisting lymphoproliferative disease and Kaposi s sarcoma (KS) has been reported. However, the association of Hodgkin s disease (HD) and KS is a rare condition, and only 41 cases have been found upon a literature review of the last 33 years. In this study the case of a 70 year-old male patient
- Attention in HIV-infected children: results from the Hemophilia Growth and Development Study.
- J Int Neuropsychol Soc. 2000 May;6(4):443-54. Unique Identifier : AIDSLINE MED/20360870
- Watkins JM; Cool VA; Usner D; Stehbens JA; Nichols S; Loveland KA; Bordeaux JD; Donfield S; Asarnow RF; Nuechterlein KH; Childrens Hospital of Orange County, Orange, California 92668,; USA. hospital.jwatkins@choc.org
- Attentional functioning was examined in three groups of 7- to 19-year-old male participants with hemophilia: (1) HIV seronegative controls (HIV-, N = 66), (2) HIV seropositive participants with CD4+ lymphocyte counts greater than or equal to 200 (HIV+ CD4+ > or = 200, N = 79), and (3) severely immune suppressed HIV se
- Cerebrospinal fluid western Blot profiles in the evolution of HIV-1 pediatric encephalopathy.
- Rom J Virol. 1998 Jan-Dec;49(1-4):61-71. Unique Identifier : AIDSLINE MED/20350348
- Ruta SM; Matusa R; Cernescu CC; Institute of Virology, Bucharest, Romania.
- In order to obtain information on neurologic AIDS, 54 white caucasian children infected by nosocomial route with a median age of 46.2 +/- 7 months were followed up prospectively for a median of 12 months with three months Denver tests neurologic evaluation and six months serologic investigations in CSF and sera. Paire
- Human immunodeficiency virus types 1 and 2 infection in some rural areas of Nigeria.
- Rom J Virol. 1998 Jan-Dec;49(1-4):89-95. Unique Identifier : AIDSLINE MED/20350351
- Odaibo GN; Olaleye OD; Tomori O; Department of Virology, College of Medicine, University College; Hospital, Ibadan, Nigeria.
- The prevalence of human immunodeficiency virus types 1 and 2 in rural areas of Nigeria was estimated using 1089 sera collected in 18 locations from 1992 to early 1994. The sera were tested with Enzyme linked Immunosorbent Assay (ELISA) and confirmed by Western Immunoblotting techn
- Granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-12 synergize with calcium ionophore to enhance dendritic cell function.
- J Immunother. 2000 May-Jun;23(3):311-20. Unique Identifier : AIDSLINE MED/20297152
- Bedrosian I; Roros JG; Xu S; Nguyen HQ; Engels F; Faries MB; Koski GK; Cohen PA; Czerniecki BJ; Department of Surgery, University of Pennsylvania, Philadelphia,; USA.
- The authors previously showed that monocytes treated with calcium ionophore (CI) acquire characteristics of mature dendritic cells (DC) in part through a calcineurin-dependent pathway. In this study, the authors evaluated the ability of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-2 (
- Intensified regression of colon cancer liver metastases in mice treated with irinotecan and the immunomodulator JBT 3002.
- J Immunother. 2000 May-Jun;23(3):321-31. Unique Identifier : AIDSLINE MED/20297153
- Shinohara H; Bucana CD; Killion JJ; Fidler IJ; Department of Cancer Biology, University of Texas M. D. Anderson; Cancer Center, Houston 77030, USA.
- The authors recently reported that tumoricidal activation of macrophages by a new synthetic bacterial lipopeptide, JBT 3002, can augment chemotherapy-mediated tumor-cell killing. The aim of this study was to identify the mechanism responsible for the destruction of metastatic cells. Three daily oral doses of JBT 3002
- Dynamics of tumor cell killing by human T lymphocytes armed with an anti-carcinoembryonic antigen chimeric immunoglobulin T-cell receptor.
- J Immunother. 2000 May-Jun;23(3):332-43. Unique Identifier : AIDSLINE MED/20297154
- Beecham EJ; Ortiz-Pujols S; Junghans RP; Biotherapeutics Development Laboratory, Harvard Medical School,; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
- Chimeric immunoglobulin T-cell receptors (IgTCR) join the antigen-binding portion of an antibody to one of the signaling chains of the TCR. A previous report described the construction and functional testing of an IgTCR gene directed against the carcinoembryonic tumor antigen (CEA). These preclinical studies showed th
- Viral load trend in HIV-1 seropositive patients with different CD4 cell counts before starting HAART.
- J Clin Virol. 2000 Jun;17(1):5-11. Unique Identifier : AIDSLINE MED/20276252
- Re MC; Ramazzotti E; Manfredi R; Furlini G; Vignoli M; Maldini C; Borderi M; La Placa M; Department of Clinical and Experimental Medicine, Section of; Microbiology, University of Bologna, Via Massarenti, 9-40138,; Bologna, Italy.
- BACKGROUND: The efficacy of highly active antiretroviral therapy (HAART) was prospectively monitored in HIV-1 seropositive patients by analyzing HIV-1 RNA viral load. OBJECTIVES: The aim of the study was to evaluate the viral load course in two different groups of patients (group 1: CD4>400/mm(3), group 2: CD4
- Evaluation of a prototype Amplicor PCR assay for detection of human immunodeficiency virus type 1 DNA in blood samples from Tanzanian adults infected with HIV-1 subtypes A, C and D.
- J Clin Virol. 2000 Jun;17(1):57-63. Unique Identifier : AIDSLINE MED/20276259
- Lyamuya E; Olausson-Hansson E; Albert J; Mhalu F; Biberfeld G; Department of Microbiology/Immunology, Muhimbili University; College of Health Sciences, University of Dar es Salaam, Box; 65001, Dar es Salaam, Tanzania.
- BACKGROUND: In previous evaluations, the standard Amplicor HIV-1 DNA PCR test (Roche Diagnostic Systems) has been reported to have low sensitivity for the detection of some non-B HIV-1 subtypes. It has therefore become necessary to determine the performance of commercially available as well as prototype HIV-1 PCR assa
- Sexual behavior change among human immunodeficiency virus-infected adolescents with hemophilia. Adolescent Hemophilia Behavioral Intervention Evaluation Project Study Group.
- Pediatrics. 2000 Aug;106(2):E22. Unique Identifier : AIDSLINE MED/20381434
- Brown LK; Schultz JR; Parsons JT; Butler RB; Forsberg AD; Kocik SM; King G; Manco-Johnson M; Aledort L; Department of Psychiatry and Human Behavior, Brown University; School of Medicine, Providence, Rhode Island, USA.; lkbrown@lifespan.org
- PURPOSE: To determine the factors associated with the adoption or maintenance of consistent safer sexual behaviors among human immunodeficiency virus-positive adolescents and young adults with hemophilia. METHODS: One hundred eleven adolescents at 10 hemophilia care sites participated in an intervention program design
- Predictors of change in the functional status of children with human immunodeficiency virus infection.
- Pediatrics. 2000 Aug;106(2):E24. Unique Identifier : AIDSLINE MED/20381436
- Missmer SA; Spiegelman D; Gorbach SL; Miller TL; Department of Epidemiology, Harvard School of Public Health,; Boston, Massachusetts, USA.
- OBJECTIVE: The purpose of this study was to identify important clinical predictors of change in the functional status of children with perinatally acquired human immunodeficiency virus (HIV) infection. METHODS: Children who were perinatally exposed to HIV underwent evaluation of growth, nutritional, and functional sta
- Early cognitive and motor development among infants born to women infected with human immunodeficiency virus. Women and Infants Transmission Study Group.
- Pediatrics. 2000 Aug;106(2):E25. Unique Identifier : AIDSLINE MED/20381437
- Chase C; Ware J; Hittelman J; Blasini I; Smith R; Llorente A; Anisfeld E; Diaz C; Fowler MG; Moye J; Kaligh LI; Department of Pediatrics, Division of Infectious Disease, Boston; Medical Center, Boston University School of Medicine, Boston,; Massachusetts 02118-2393, USA. cynthia.chase@bmc.org
- OBJECTIVE: To examine the frequency, timing, and factors associated with abnormal cognitive and motor development during the first 30 months of life in infants born to women infected with human immunodeficiency virus type 1 (HIV-1). METHODS: Serial neurodevelopmental assessment was performed with 595 infants born to w
- Prevalence of HIV, hepatitis B, and hepatitis C antibodies in prisoners in England and Wales: a national survey [see comments]
- Commun Dis Public Health. 2000 Jun;3(2):121-6. Unique Identifier : AIDSLINE MED/20360712
- Weild AR; Gill ON; Bennett D; Livingstone SJ; Parry JV; Curran L; PHLS Communicable Disease Surveillance Centre, London.; awield@phls.nhs.uk
- Prisoners in eight of the 135 prisons in England and Wales were surveyed in 1997 and 1998 to study the prevalence of and risk factors for transmission of bloodborne viruses in prison. Subjects voluntarily completed a risk factor questionnaire and provided oral fluid specimens for unlinked anonymous testing for the pre
- Lookbacks for HIV infected health care workers [letter]
- Commun Dis Public Health. 2000 Jun;3(2):143-4. Unique Identifier : AIDSLINE MED/20360720
- Robinson E; Joce R; O'Donovan D; Bruce M; Gaudoin J; Iversen A; Hargreaves R; Hamilton G
- Science, sense, and nonsense about HIV in Africa [editorial]
- Commun Dis Public Health. 2000 Jun;3(2):78-9. Unique Identifier : AIDSLINE MED/20360701
- Nicoll A; Killewo J
- Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug.
- Bioorg Med Chem Lett. 2000 Apr 3;10(7):645-7. Unique Identifier : AIDSLINE MED/20222681
- McGuigan C; Slater MJ; Parry NR; Perry A; Harris S; Welsh School of Pharmacy, Cardiff University, UK.; mcguigan@cardiff.ac.uk
- We describe a synthesis of acyclovir-5 -(phenyl methoxy alaninyl) phosphate (2) from acyclovir (1). This compound was designed to act as a lipophilic, membrane-soluble prodrug of the free nucleotide. However, the biological activities of this derivative against a range of viruses indicated poor intracellular phosphate
- Bleeding episodes in HIV-positive patients taking HIV protease inhibitors: a case series.
- Haemophilia. 1999 Jul;5(4):266-9. Unique Identifier : AIDSLINE MED/99398888
- Racoosin JA; Kessler CM; Food and Drug Administration, Center for Drug Evaluation and; Research, USA.
- In July 1996 the Food and Drug Administration ( FDA ) alerted healthcare providers about 15 case reports of spontaneous bleeding episodes in HIV-positive haemophiliacs taking HIV protease inhibitors . In order to characterize the bleed
- Stability of some novel thymidine, 5-bromo-2'-deoxyuridine and 3'-azido-2'-3'-dideoxythymidine analogues.
- Int J Pharm. 2000 May 10;200(2):181-5. Unique Identifier : AIDSLINE MED/20328171
- Zhivkova Z; Stankova I; Department of Chemistry, Faculty of Pharmacy, Medical University,; 2 Dunav, 1000, Sofia, Bulgaria. tzzhivkova@mbox.pharmfac.acad.bg
- In the search of new prodrugs effective against herpes simplex virus series of thymidine, 5-bromo-2 -deoxyuridine esters with amino acid and peptide chains and 3 -azido-2 ,3 -dideoxythymidine derivatives have been synthesized and evaluated for antiviral activity. The chemical stability of some of them containing diffe
- Using a case-mix-adjusted pressure sore incidence study in a surgical directorate to improve patient outcomes in pressure ulcer prevention.
- Unique Identifier : AIDSLINE MED/20268890
- Watret L
- The Glasgow Acute Clinical Audit Sub-Committee on Pressure Sores has previously carried out studies of incidence of pressure ulcers in the medical directorates and case-mix-adjusted the figures for length of hospital stay and risk assessment score. Case-mix classification is classification of people or treatment plac
- Human herpesvirus 6.
- Rev Med Virol. 2000 May-Jun;10(3):155-73. Unique Identifier : AIDSLINE MED/20276264
- Clark DA; Department of Virology, Royal Free and University College Medical; School, London, UK.
- Human herpesvirus 6 (HHV-6), a member of the beta-herpesvirinae subfamily, is highly seroprevalent, has a worldwide distribution, and infection usually occurs within the first two years of life. In this age group, HHV-6 causes febrile illness including exanthem subitum with seizures a recognised complication. The viru
- Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):100-5. Unique Identifier : AIDSLINE MED/20388727
- Ewings EL; Gerschenson M; St Claire MC; Nagashima K; Skopets B; Harbaugh SW; Harbaugh JW; Poirier MC; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.
- Mitochondrial toxicity was assessed in the brains of developing Erythrocebus patas monkey fetuses exposed in utero to the nucleoside analogue drug zidovudine (3 -azido-3 deoxythymidine or AZT ). Pregnant E. patas monkeys were given 0 (n = 5), 10 (n = 3
- Physician experience in the care of HIV-infected persons is associated with earlier adoption of new antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):106-14. Unique Identifier : AIDSLINE MED/20388728
- Kitahata MM; Van Rompaey SE; Shields AW; Department of Medicine, University of Washington, Seattle, USA.; kitahata@u.washington.edu
- OBJECTIVE: Recent advances in antiretroviral therapy have led to effective but increasingly complex strategies for the treatment of HIV infection. In a previous study, we demonstrated that physicians experience in the care of patients with AIDS improves survival. We conducted this study to determine whether greater p
- Outcome of a second-line protease inhibitor-containing regimen in patients failing or intolerant of a first highly active antiretroviral therapy.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):115-22. Unique Identifier : AIDSLINE MED/20388729
- Bini T; Testa L; Chiesa E; Adorni F; Abeli C; Castelnuovo B; Melzi S; Sollima S; Bongiovanni M; d'Arminio Monforte A; Institute of Infectious and Tropical Diseases, L. Sacco Hospital,; University of Milan, Italy.
- The outcome of second-line protease inhibitor (PI)-containing highly active antiretroviral therapy (HAART) was investigated in 263 patients who were failed by (n = 148) or intolerant of (n = 115) a first HAART regimen. The endpoints were virologic failure (decline in HIV RNA or = 2 months)
- Patient-reported nonadherence to HAART is related to protease inhibitor levels.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):123-8. Unique Identifier : AIDSLINE MED/20388730
- Murri R; Ammassari A; Gallicano K; De Luca A; Cingolani A; Jacobson D; Wu AW; Antinori A; Department of Infectious Diseases, Catholic University of Rome,; Italy. ritanto@iol.it
- OBJECTIVE: To compare self-reported nonadherence with antiretroviral therapy (ART) with predose plasma levels of protease inhibitor (PI). DESIGN: A cross-sectional study of consecutive patients from a university-based HIV clinic in Rome, Italy , was conducted. One hundred and forty H
- Differential impairment of triazolam and zolpidem clearance by ritonavir.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):129-36. Unique Identifier : AIDSLINE MED/20388731
- Greenblatt DJ; von Moltke LL; Harmatz JS; Durol AL; Daily JP; Graf JA; Mertzanis P; Hoffman JL; Shader RI; Department of Pharmacology and Experimental Therapeutics, Tufts; University School of Medicine, New England Medical Center,; Boston, Massachusetts 02111, USA. dj.greenblatt@tufts.edu
- BACKGROUND: The viral protease inhibitor ritonavir has the capacity to inhibit and induce the activity of cytochrome P450-3A (CYP3A) isoforms, leading to drug interactions that may influence the efficacy and toxicity of other antiretroviral therapies, as well as pharmacologic treatments of coincident or complicating d
- Relation of lean body mass to health-related quality of life in persons with HIV.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):137-46. Unique Identifier : AIDSLINE MED/20388732
- Wilson IB; Roubenoff R; Knox TA; Spiegelman D; Gorbach SL; Department of Medicine, New England Medical Center, Tufts; University, Boston, Massachusetts 02111, USA.; IWilson@Lifespan.org
- OBJECTIVE: To determine the nature and strength of the relation between lean body mass and measures of health-related quality-of-living (HRQL) including physical functioning in men and women with HIV. DESIGN: Cross-sectional analysis using 619 patients with HIV infection from two cities in the northeastern
- Protection of cynomolgus macaque against cervicovaginal transmission of SIVmac251 by the spermicide benzalkonium chloride.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):147-53. Unique Identifier : AIDSLINE MED/20388733
- Tevi-Benissan C; Makuva M; MorelliA; Georges-Courbot MC; Matta M; Georges A; Belec L; Centre International de Recherches Medicales de Franceville,; Gabon.
- We evaluated the potential effectiveness of a spermicide cationic surfactant, benzalkonium chloride (BZK), to prevent the transmission of simian immunodeficiency virus (SIV) after intravaginal inoculation in 12 cynomolgus macaques. The inoculation procedure involved deposition of 6.7 ivag-AID50 of cell-free SIVmac251
- Effect of prenatal zidovudine on disease progression in perinatally HIV-1-infected infants.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):154-61. Unique Identifier : AIDSLINE MED/20388734
- de Souza RS; Gomez-Marin O; Scott GB; Guasti S; O'Sullivan MJ; Oliveira RH; Mitchell CD; Universidade de Caxias do Sul, Brazil.
- OBJECTIVE: To determine the influence of prenatal zidovudine (ZDV) prophylaxis on the course of HIV- 1 infection in children by comparing the clinical outcome of infants born to HIV- 1-seropositive mothers who did versus those who did not receive ZDV during pregnancy. METHODS: Medical records of HIV-1-seropositive mot
- Sex- and drug-related risk among populations of younger and older injection drug users in adjacent neighborhoods in San Francisco.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):162-7. Unique Identifier : AIDSLINE MED/20388735
- Kral AH; Lorvick J; Edlin BR; Urban Health Study, Institute for Health Policy Studies, School; of Medicine, University of California, San Francisco 94110, USA.; alkral@itsa.ucsf.edu
- The objective of this study was to compare drug injection- and sex-related risk behaviors of younger and older injection drug users (IDUs) in two adjacent neighborhoods. IDUs were recruited from street settings in two adjacent neighborhoods in San Francisco in April, 1997. All participants were interviewed using a sta
- Very young gay and bisexual men are at risk for HIV infection: the San Francisco Bay Area Young Men's Survey II.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):168-74. Unique Identifier : AIDSLINE MED/20388736
- Waldo CR; McFarland W; Katz MH; MacKellar D; Valleroy LA; Center for AIDS Prevention Studies, AIDS Research Institute, and; Department of Medicine, University of California, San Francisco; 94105, USA. cwaldo@psg.ucsf.edu
- OBJECTIVES: To compare HIV seroprevalence and sexual risk behavior among very young gay and bisexual men (aged 15-17 years) and their older counterparts (aged 18-22 years). To examine drug-use patterns and correlates of sexual risk behavior in both of these age groups. DESIGN AND METHODS: An interviewer-administered c
- Identification of a high-risk heterosexual population for HIV prevention trials in Rio de Janeiro, Brazil. Projeto Praco Onze Study Group.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):175-7. Unique Identifier : AIDSLINE MED/20388737
- Schechter M; do Lago RF; de Melo MF; Sheppard HW; Guimaraes NC; Moreira RI; Faulhaber JC; Batista S; Harrison LH; Infectious Diseases Service, Hospital Universitario Clementino; Fraga Filho, Department of Preventive Medicine, Universidade; Federal do Rio de Janeiro, Brazil. maurosch@hucff.ufrj.br
- The study of interventions to prevent HIV transmission requires access to populations with a high rate of HIV transmission. We estimated HIV incidence among heterosexual males and females who were seen at an HIV testing site in Rio de Janeiro, Brazil . Stored sera from individuals w
- HIV/AIDS epidemic in French Guiana: 1979-1997. Groupe d'Etude Clinique de l'Infection VIH en Guyane Francaise.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):178-81. Unique Identifier : AIDSLINE MED/20388738
- Sobesky M; Dabis F; Le Beux P; Centre d'Information et de Soins de l'Immuno-Deficience Humaine,; Cayenne, French Guiana. sobeskym@nplus.gf
- The incidence of AIDS in French Guiana remains one of the highest in Latin America and the Caribbean. The annual AIDS incidence rate increased continually from the start of the epidemic until 1995, when it reached 59.3/100,000 popul
- Estimating the national cost of treating people with HIV disease: patient, payer, and provider data.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):182-8. Unique Identifier : AIDSLINE MED/20388739
- Hellinger FJ; Fleishman JA; Agency for Healthcare Research and Quality, Rockville, Maryland; 20852, USA. fhelling@ahrq.gov
- OBJECTIVE: Existing estimates of the national cost of treating all people with HIV disease use data from a sample of people with HIV disease to extrapolate the cost of treating all people with HIV disease (patient-based approach). This study derives estimates using two novel approaches (i.e., payer-based and provider-
- In vivo fluctuation of HTLV-I and HTLV-II proviral load in patients receiving antiretroviral drugs.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):189-93. Unique Identifier : AIDSLINE MED/20388740
- Machuca A; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- HTLV-I and HTLV-II infect T lymphocytes. A high HTLV-I proviral load in peripheral blood mononuclear cells (PBMCs) has been associated with a higher risk of neurologic disease. For HTLV-II, large numbers of infected lymphocytes might contribute to accelerate the immunodeficiency and increase the risk of neuropathy in
- Salvage therapy and formulation of highly active antiretroviral therapy [letter]
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):194-5. Unique Identifier : AIDSLINE MED/20388741
- Fessel WJ; Follansbee SE; Young TP
- Inverse correlation of telomerase activity/proliferation of CD4+ T lymphocytes and disease progression in simian immunodeficiency virus-infected nonhuman primates.
- J Acquir Immune Defic Syndr. 2000 Jun 1;24(2):89-99. Unique Identifier : AIDSLINE MED/20388726
- Bostik P; Brice GT; Greenberg KP; Mayne AE; Villinger F; Lewis MG; Ansari AA; Department of Pathology and Laboratory Medicine, Winship Cancer; Center, Emory University School of Medicine, Atlanta, Georgia; 30322, USA. pbostik@emory.edu
- Both increased lymphocyte renewal with subsequent exhaustion of the immune system and impaired T-cell renewal have been put forth to account for CD4+ T-cell depletion and development of AIDS in HIV-1-infected humans and SIV-infected nonhuman primates. In the present study, telomeric terminal restriction fragment lengt
- [Rapid treatment of scabies with a single ivermectin administration. Routine topical treatment takes several days (news)]
- MMW Fortschr Med. 1999 Sep 2;141(35):42. Unique Identifier : AIDSLINE MED/20356159
- Jansen T; Klinikum Innenstadt der Ludwig-Maximilians-Universitat Munchen.
- [Resistance tests to improve therapy. More specific use of AIDS drugs (news)]
- MMW Fortschr Med. 1999 Sep 16;141(37):18. Unique Identifier : AIDSLINE MED/20356172
- Paukstadt W
- Cotrimoxazole for prenatal treatment of congenital toxoplasmosis?
- Parasitol Today. 2000 Jun;16(6):254-6. Unique Identifier : AIDSLINE MED/20287823
- Derouin F; Jacqz-Aigrain E; Thulliez P; Couvreur J; Leport C; Laboratoire de Parasitologie-Mycologie, hopital Saint-Louis, 1; avenue Claude Vellefaux, 75475 Paris Cedex 10, France.
- Congenital toxoplasmosis is still one of the most frequent causes of fetal death. Despite a significant improvement in diagnosis, particularly in utero diagnosis, maternal treatment is only partially effective in preventing transmission to the fetus and treating fetal infection. Maternal treatment is based on drugs de
- Hematospermia as the presenting symptom of metastatic malignant melanoma of unknown primary origin.
- Urology. 2000 Aug 1;56(2):330. Unique Identifier : AIDSLINE MED/20385372
- Meng MV; Werboff LH; Department of Urology, University of California, San Francisco,; School of Medicine, San Francisco, California 94143-0738, USA.
- The presence of blood in the ejaculate is alarming to patients and may arise from many sources in the genitourinary tract. Fortunately, hematospermia is rarely due to underlying malignancy and only necessitates further evaluation with continued symptoms. We report a case of persistent hematospermia in a man with human
- Clinical evaluation of the efficacy and tolerability of ritonavir in combination with two reverse transcriptase inhibitors.
- Braz J Infect Dis. 2000 Feb;4(1):29-35. Unique Identifier : AIDSLINE MED/20251383
- Gomes de Arruda EA; Pedrosa De Oliveira Junior FR; Martins Maia F; Ary Duque I; Sao Jose Hospital for Infectious Diseases, Ceara State,; Department of Health, Fortaleza, Ceara, Brazil.; ericoarruda@secref.com.br
- A retrospective study of 76 patients was carried out using ritonavir in an antiretroviral regimen combined with two reverse transcriptase inhibitors to treat outpatients from July, 1996, to April, 1998, with the objective of evaluating clinical effica
- Successful nonoperative management of delayed spontaneous esophageal perforation in patients with human immunodeficiency virus.
- Crit Care Med. 2000 Jul;28(7):2634-7. Unique Identifier : AIDSLINE MED/20377076
- Serna DL; Vovan TT; Roum JH; Brenner M; Chen JC; Division of Pulmonary and Critical Care Medicine, University of; California, Irvine, USA.
- OBJECTIVE: To describe the clinical outcome of esophageal stenting for repair of distal esophageal perforation in one patient with septic shock and human immunodeficiency virus. DESIGN: Case report. SETTING: Medical-surgical intensive care units of one university teaching hospital. PATIENT: One patient with human immu
- Clinical course, prognostic factors, and outcome prediction for HIV patients in the ICU. The PIP (Pulmonary complications, ICU support, and prognostic factors in hospitalized patients with HIV) study.
- Chest. 2000 Jul;118(1):138-45. Unique Identifier : AIDSLINE MED/20353408
- Afessa B; Green B; Department of Internal Medicine, Division of Pulmonary and; Critical Care, University of Florida Health Science Center,; Jacksonville, FL, USA. Afessa.bekele@Mayo.edu
- STUDY OBJECTIVE: To describe the clinical course and prognostic factors in patients with HIV admitted to the ICU. DESIGN: Prospective, observational. SETTING: A university-affiliated medical center. METHODS:: We included 169 consecutive ICU admissions, from April 1995 through March 1999, of 141 adults with HIV. Data c
- Talc granulomatosis. A differential diagnosis of interstitial lung disease in HIV patients.
- Chest. 2000 Jul;118(1):258-60. Unique Identifier : AIDSLINE MED/20353429
- Nan DN; Fernandez-Ayala M; Iglesias L; Garcia-Palomo D; Parra JA; Farinas MC; Infectious Diseases Unit, Department of Internal Medicine,; Universitario Marques de Valdecilla, Universidad de Cantabria,; Santander, Spain.
- Consumers of adulterated drugs may present with talc-induced interstitial lung disease. A transbronchial biopsy specimen showing granulomas with intracellular talc crystals is necessary to confirm this diagnosis. In patients infected with HIV, such a condition can be indistinguishable at first glance from opportunisti
- Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8(+) T lymphocytes. The ACTG Advanced Flow Cytometry Focus Group.
- Cytometry. 2000 Jun 15;42(3):174-9. Unique Identifier : AIDSLINE MED/20320747
- Schmitz JL; Czerniewski MA; Edinger M; Plaeger S; Gelman R; Wilkening CL; Zawadzki JA; Wormsley SB; Department of Pathology and Laboratory Medicine, University of; North Carolina, Chapel Hill, North Carolina, USA.; jschmitz@unch.unc.edu
- We evaluated the effect of specimen processing variations and quantitation methods on quantitative determination of CD38 expression on CD8 T lymphocytes. Neither lysing reagent (ammonium chloride versus BD FACSlyse), fixation (paraformaldehyde versus no final fixation step), nor acquisition delay (acquisition within 6
- Use of buprenorphine in HIV-infected injection drug users: negligible impact on virologic response to HAART. The Manif-2000 Study Group.
- Drug Alcohol Depend. 2000 Jul 1;60(1):51-4. Unique Identifier : AIDSLINE MED/20283509
- Carrieri MP; Vlahov D; Dellamonica P; Gallais H; Lepeu G; Spire B; Obadia Y; INSERM research Unit 379 'Epidemiology and Social Sciences; Applied to Medical Innovation', Institut Paoli Calmettes, 23 rue; Stanislas Torrents, Marseille, France.
- Some HIV-infected injecting drug users (IDUs) on drug abuse maintenance treatment have access to highly active antiretroviral therapy (HAART); this raises questions about the effects of individual treatments on the efficacy of HAART. The French Cohort Study of HIV-infected IDUs - MANIF-2000 - allowed one to assess whe
- Drug abuse, methadone treatment, and health services use among injection drug users with AIDS.
- Unique Identifier : AIDSLINE MED/20283512
- Sambamoorthi U; Warner LA; Crystal S; Walkup J
- This paper compares health care use across subgroups of injection drug users (IDUs) with AIDS, as defined by current drug abuse status and participation in methadone maintenance treatment (MMT), using surveillance-identified IDU status and health care claims data. Merged Medicaid and AIDS surveillance data were analyz
- [The value of bronchoalveolar lavage in the clarifying of HIV-associated lung diseases]
- Dtsch Med Wochenschr. 2000 Jun 23;125(25-26):789-93. Unique Identifier : AIDSLINE MED/20373206
- Ersch J; Speich R; Weber R; Altwegg M; Hauser M; Departement Innere Medizin, Universitatsspital Zurich.
- BACKGROUND AND OBJECTIVE: Examination of sputum is the first diagnostic step in the evaluation of HIV-infected patients with pulmonary complications. We were interested in the indications and the diagnostic value of subsequent bronchoscopy and bronchoalveolar lavage (BAL) and especially the importance of so-called aty
- Assembly of heterodimeric luciferase after de novo synthesis of subunits in rabbit reticulocyte lysate involves hsc70 and hsp40 at a post-translational stage.
- Eur J Biochem. 2000 Jun;267(12):3575-82. Unique Identifier : AIDSLINE MED/20307592
- Tyedmers J; Kruse M; Lerner M; Demand J; Hohfeld J; Solsbacher J; Volkmer J; Zimmermann R; Medizinische Biochemie und Molekularbiologie, Universitat des; Saarlandes, Homburg, Germany.
- Heterodimeric luciferase from Vibrio harveyi had been established as a unique model enzyme for direct measurements of the effects of molecular chaperones and folding catalysts on protein folding and subunit assembly after de novo synthesis of subunits in rabbit reticulocyte lysate. It was observed that luciferase asse
- Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells.
- Eur J Biochem. 2000 Jun;267(12):3604-12. Unique Identifier : AIDSLINE MED/20307595
- Hoischen SH; Vollmer P; Marz P; Ozbek S; Gotze KS; Peschel C; Jostock T; Geib T; Mullberg J; Mechtersheimer S; Fischer M; Grotzinger J; Galle PR; Rose-John S; Johannes Gutenberg University of Mainz, Germany.
- Human herpes virus-8 (HHV8) encodes a cytokine named viral interleukin-6 (vIL-6) that shares 25% amino-acid identity with its human homologue. Human IL-6 is known to be a growth and differentiation factor of lymphatic cells and plays a potential role in the pathophysiology of various lymphoproliferative diseases. vIL-
- Interactions of the C-terminus of viral protein R with nucleic acids are modulated by its N-terminus.
- Eur J Biochem. 2000 Jun;267(12):3654-60. Unique Identifier : AIDSLINE MED/20307601
- de Rocquigny H; Caneparo A; Delaunay T; Bischerour J; Mouscadet JF; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale,; INSERM U266, CNRS UMR 8600, Faculte de Pharmacie 4, Paris,; France.
- The basic viral protein R (Vpr) performs several functions during the human immunodeficiency virus HIV-1 retroviral cycle, including G2 mitosis arrest and nuclear import of the preintegration complex allowing lentivirus to replicate in nondividing cells. Accordingly, this protein was found in the nucleus of infected c
- Liposome-mediated cytosolic delivery of macromolecules and its possible use in vaccine development.
- Eur J Biochem. 2000 Jul;267(13):3946-56. Unique Identifier : AIDSLINE MED/20325070
- Owais M; Gupta CM; Inter-disciplinary Biotechnology Unit, Aligarh Muslim University,; India.
- In the majority of bacterial and viral infections the generation of cytotoxic T cells is of particular interest because such pathogens are able to escape the host defence mechanisms by surviving intracellularly within the phagocytic cells. To generate a CD8+ T lymphocyte response against exogenous antigens, the prereq
- Expanding baculovirus surface display. Modification of the native coat protein gp64 of Autographa californica NPV.
- Eur J Biochem. 2000 Jul;267(13):4033-9. Unique Identifier : AIDSLINE MED/20325080
- Ernst WJ; Spenger A; Toellner L; Katinger H; Grabherr RM; Institute of Applied Microbiology, University of Agriculture,; Vienna, Austria.
- To create a tool for eukaryotic surface display, this approach is aimed at demonstrating a direct modification of the native envelope protein gp64 of Autographa californica NPV without disturbing viral infectivity. Short affinity-tag peptides, the biotin mimic streptagII, and the gp41 amino-acid motif ELDKWA of HIV-1,
- Clinical and microbiological survey of Serratia marcescens infection during HIV disease.
- Eur J Clin Microbiol Infect Dis. 2000 Apr;19(4):248-53. Unique Identifier : AIDSLINE MED/20292664
- Manfredi R; Nanetti A; Ferri M; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, S. Orsola Hospital, Italy. malinf@med.unibo.it
- Clinical charts of 2,398 consecutive HIV-infected patients hospitalized over an 8-year period were reviewed retrospectively to identify all cases of Serratia infection and to evaluate the occurrence and outcome of these cases according to several epidemiological. clinical, and laboratory parameters. Seventeen of 2,398
- Transient transmission of hepatitis C virus from mothers to newborns.
- Eur J Clin Microbiol Infect Dis. 2000 Apr;19(4):267-74. Unique Identifier : AIDSLINE MED/20292667
- Ketzinel-Gilad M; Colodner SL; Hadary R; Granot E; Shouval D; Galun E; Liver Unit, Hadassah University Hospital, Ein Kerem, Jerusalem,; Israel.
- A study was performed in Israel to determine the rate of mother-to-infant HCV transmission in newborns at risk. A group of 22 HCV-infected mothers and their 23 newborns were followed up from early after birth by testing their serum for the presence of HCV antibodies and HCV-RNA. An
- [Mortality risk in intravenous drug users in Emilia Romagna region and its socio-demographic determinants. Results of a longitudinal study]
- Epidemiol Prev. 2000 Mar-Apr;24(2):75-80. Unique Identifier : AIDSLINE MED/20322187
- Ciccolallo L; Morandi G; Pavarin R; Sorio C; Buiatti E; Centro di documentazione per la salute, Aziende USL Citta di; Bologna e Ravenna. Laura.Ciccolallo@ausl.bologna.it
- Results on general and cause-specific mortality in a retrospective cohort of intravenous drug users in the Emilia Romagna Region ( Italy ) are presented. Four thousand two hundred and sixty subjects (3324 males, 936 females) in public treatment centres in Piacenza, Modena and Ferrara
- Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy.
- Biochem Soc Trans. 2000 Feb;28(2):212-5. Unique Identifier : AIDSLINE MED/20273642
- Piccinni MP; Maggi E; Romagnani S; Immunoallergology and Diseases of Respiratory Apparatus,; Department of Internal Medicine, University of Florence, Italy.
- Human CD4 T helper lymphocytes can be subdivided into at least three distinct functional subsets on the basis of their cytokine secretion profiles. One type of CD4+ lymphocyte, T helper 1 (Th1), produces interferon (IFN)-gamma and tumour necrosis factor beta, a second type (Th2) produces interleukin (IL)-4 and IL-5 an
- Regulation of apoptosis and replicative senescence in CD8+ T cells from patients with viral infections.
- Biochem Soc Trans. 2000 Feb;28(2):255-8. Unique Identifier : AIDSLINE MED/20273650
- Soares MV; Maini MK; Beverley PC; Salmon M; Akbar AN; Department of Clinical Immunology, Royal Free and University; College Medical School, London, UK.
- Activated T lymphocytes are generated during an immune response. The induction of T lymphocyte proliferation is one way in which cell numbers can be controlled. However, once generated, the increased numbers of cells must be removed in order to re-establish cellular homoeostasis within the immune system. In this paper
- Origins and evolution of AIDS viruses: estimating the time-scale.
- Biochem Soc Trans. 2000 Feb;28(2):275-82. Unique Identifier : AIDSLINE MED/20273654
- Sharp PM; Bailes E; Gao F; Beer BE; Hirsch VM; Hahn BH; Institute of Genetics, University of Nottingham, Queens Medical; Centre, UK.
- The primate lentiviruses comprise SIV strains from various host species, as well as two viruses, HIV-1 and HIV-2, that cause AIDS in humans. The origins of HIV-1 and HIV-2 have been traced to cross-species transmissions from chimpanzees and sooty mangabey monkeys respectively. Two approaches have been taken to estimat
- 1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543).
- Unique Identifier : AIDSLINE MED/20378132
- Overbergh L; Decallonne B; Waer M; Rutgeerts O; Valckx D; Casteels KM; Laureys J; Bouillon R; Mathieu C; Laboratory for Experimental Transplantation, Universitair; Ziekenhuis Gasthuisberg, Catholic University of Leuven, Belgium.
- Prevention of type 1 diabetes in NOD mice by 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] is accompanied by a T-helper (Th) 1/Th2 cytokine shift in the pancreas. The aim of this study was to investigate whether this immune shift also occurs outside of the pancreas and whether it is limited to autoantigen-specific immun
- Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice.
- FEMS Microbiol Lett. 2000 May 1;186(1):121-6. Unique Identifier : AIDSLINE MED/20243471
- Kawakami K; Koguchi Y; Qureshi MH; Kinjo Y; Yara S; Miyazato A; Kurimoto M; Takeda K; Akira S; Saito A; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan.; kawakami@med.u-ryukyu.ac.jp
- Using interleukin (IL)-18 deficient (IL-18(-/-)) mice, we examined the role of IL-18 in the host resistance and Th1 response against infection with Cryptococcus neoformans. Fungal clearance in the lung was reduced in IL-18(-/-) mice, although there was no significant change in the level of dissemination to the brain.
- Lineage commitment in the immune system: the T helper lymphocyte grows up.
- Genes Dev. 2000 Jul 15;14(14):1693-711. Unique Identifier : AIDSLINE MED/20357103
- Glimcher LH; Murphy KM; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115-6017, USA.; lgimche@hsph.harvard.edu
- Chromosomal aberrations evaluated by CGH, FISH and GTG-banding in a case of AIDS-related Burkitt's lymphoma.
- Haematologica. 2000 Mar;85(3):250-5. Unique Identifier : AIDSLINE MED/20169250
- Zunino A; Viaggi S; Ottaggio L; Fronza G; Schenone A; Roncella S; Abbondandolo A; Mutagenesis Laboratory, National Cancer Institute (IST), largo; Rosanna Benzi 10, 16132 Genova, Italy. zuninoa@hp380.ist.unige.it
- BACKGROUND AND OBJECTIVE: We have previously reported on a complex chromosome rearrangement [der(17)] in a B-cell line, BRG A, established from an AIDS patient with Burkitt s lymphoma (BL). The aim of the present study was the definition of der(17) composition and the identification of complete or partial chromosome g
- Usefulness of the prognostic score for advanced Hodgkin's disease in patients with human immunodeficiency virus-associated Hodgkin's lymphoma [letter]
- Haematologica. 2000 Mar;85(3):325-6. Unique Identifier : AIDSLINE MED/20169267
- Ribera JM; Navarro JT; Oriol A; Vaquero M; Grau J; Feliu E
- Lamivudine for the prevention of hepatitis B virus reactivation during autologous stem cell transplantation. A case report [letter]
- Haematologica. 2000 Mar;85(3):327-9. Unique Identifier : AIDSLINE MED/20169269
- Silvestri F; Sperotto A; Ermacora A; Fanin R; Damiani D; Baccarani M
- Disseminated toxoplasmosis after CD34+-selected autologous peripheral blood stem cell transplantation [letter]
- Haematologica. 2000 Mar;85(3):334-5. Unique Identifier : AIDSLINE MED/20169273
- Nakane M; Ohashi K; Tominaga J; Akiyama H; Hiruma K; Sakamaki H
- [New treatments in AIDS--a true revolution (editorial)]
- Harefuah. 1998 Apr 15;134(8):616-20. Unique Identifier : AIDSLINE MED/20369079
- Stein M; Bentwich Z
- Multiple HLA-class I-specific inhibitory NK receptor expression and IL-4/IL-5 production by CD8+ T-cell clones in HIV-1 infection.
- Unique Identifier : AIDSLINE MED/20342891
- De Maria A; Mavilio D; Costa P; Dignetti P; Fogli M; Mingari MC; Allergy and Respiratory Diseases Unit, Department of Internal; Medicine (Di.M.I.), University of Genoa, Genoa, Italy.; demaria@ermes.cba.unige.it
- Several mechanisms may contribute to the decline in HIV-1 specific CD8+ cytotoxic T-lymphocyte (CTL) activity that is observed in infected patients, including loss of CD4+ cell help, antigenic shift, impaired clonogenicity and functional impairment due to expression of inhibitory NK receptors (iNKRs). In addition to a
- Seropositivity to human herpesvirus 8 in relation to sexual history and risk of sexually transmitted infections among women.
- Int J Cancer. 2000 Jul 15;87(2):232-5. Unique Identifier : AIDSLINE MED/20320831
- Tedeschi R; Caggiari L; Silins I; Kallings I; Andersson-Ellstrom A; De Paoli P; Dillner J; Department of Microbiology-Immunology and Virology, Centro di; Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy.
- The mode of transmission of human herpesvirus 8 (HHV8) was investigated in two seroepidemiological studies of Swedish women who completed a questionnaire about sexual behavior. Seropositivity for HHV8 antibodies, measured using an indirect immunofluorescence assay, was linked to a high number (>10) of sexual partners
- Naturally processed and concealed HLA-A2.1-restricted epitopes from tumor-associated antigen tyrosinase-related protein-2.
- Int J Cancer. 2000 Jul 15;87(2):241-6. Unique Identifier : AIDSLINE MED/20320833
- Noppen C; Levy F; Burri L; Zajac P; Remmel E; Schaefer C; Luscher U; Heberer M; Spagnoli GC; Research Division, Department of Surgery (F. Harder), University; of Basel, Basel, Switzerland. cnoppen@uhbs.ch
- In this study, a computer-assisted reverse immunology approach was utilized in order to identify potentially antigenic peptides derived from the differentiation antigen TRP-2, a melanosomal protein frequently expressed in melanoma. Among the seven peptides complying with HLA-A2.1-binding motifs, two induced specific C
- High frequencies of circulating melanoma-reactive CD8+ T cells in patients with advanced melanoma.
- Int J Cancer. 2000 Sep 1;87(5):659-64. Unique Identifier : AIDSLINE MED/20384685
- Letsch A; Keilholz U; Schadendorf D; Nagorsen D; Schmittel A; Thiel E; Scheibenbogen C; Universitatsklinikum Benjamin Franklin, Medizinische Klinik III; (Hamatologie, Onkologie und Transfusionsmedizin), Freie; Universitat Berlin, Berlin, Germany.
- To determine whether circulating tumor-reactive T cells are present in melanoma patients, unstimulated T cells from peripheral blood were tested for recognition of HLA-A2- or HLA-A1-matched melanoma cell lines using the ELISPOT assay. Eleven out of 19 patients with metastatic melanoma had a T-cell response with up to
- Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses.
- Int J Cancer. 2000 Sep 1;87(5):665-72. Unique Identifier : AIDSLINE MED/20384686
- Furumoto K; Arii S; Yamasaki S; Mizumoto M; Mori A; Inoue N; Isobe N; Imamura M; Department of Surgery and Surgical Basic Science, Graduate School; of Medicine, Kyoto University, Kyoto, Japan.; furuka@kuhp.kyoto-u.ac.jp
- The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m
- Transfer of IFNgamma-depleted CD4(+) T cells together with CD8(+) T cells leads to rejection of murine kidney sarcoma in mice.
- Int J Cancer. 2000 Sep 1;87(5):673-9. Unique Identifier : AIDSLINE MED/20384687
- Klugewitz K; Scheffold A; Radbruch A; Hamann A; Medizinische Klinik mit Schwerpunkt Rheumatologie, Charite,; Humboldt-University, Berlin, Germany. klugewitz@drfz.de
- In the murine kidney sarcoma, vaccination with the tumor-specific large T antigen induces protective immunity against the tumor. Immunity is dependent both on CD8(+) cytotoxic T cells and on CD4(+) T-helper cells. We analyzed whether the cytokine phenotype of induced CD4(+) T-effector cells might determine whether or
- Thrombin induces apoptosis in human tumor cells.
- Int J Cancer. 2000 Sep 1;87(5):707-15. Unique Identifier : AIDSLINE MED/20384691
- Ahmad R; Knafo L; Xu J; Sindhu ST; Menezes J; Ahmad A; Laboratory of Immunovirology, Pediatric Research Center and; Department of Microbiology and Immunology, University of Montreal; and Sainte-Justine Hospital, Montreal, Quebec, Canada.; ahmada@justine.umontreal.ca
- Thrombin is a serine protease that is produced during the coagulation process and plays an essential role for hemostasis, thrombosis and wound healing. It is a potent activator of platelets, induces proliferation of a wide variety of normal and malignant human cells, and enhances their invasiveness and metastatic pote
- [Quality management requires continuous education. Part 2: Infections--noninfectious dermatoses--peripheral venous diseases]
- Internist (Berl). 2000 Jun;41(6):599-603. Unique Identifier : AIDSLINE MED/20364626
- Stiefelhagen P; DRK-Krankenhaus Westerwald, Innere Abteilung, Hachenburg.
- In vitro anti-HIV-1 virucidal activity of tyrosine-conjugated tri- and dihydroxy bile salt derivatives.
- J Antimicrob Chemother. 2000 May;45(5):617-21. Unique Identifier : AIDSLINE MED/20259462
- Al-Jabri AA; Wigg MD; Elias E; Lambkin R; Mills CO; Oxford JS; Department of Medical Microbiology and Retroscreen Virology, St; Bartholomew's and The Royal London School of Medicine and; Dentistry, 64 Turner Street, London, UK. aaljabri@squ.edu.om
- The cellular toxicity and anti-human immunodeficiency virus type 1 (HIV-1) virucidal activity of four synthesized tyrosine-conjugated bile salt derivatives with high surfactant activities, namely di-iodo-deoxycholyltyrosine (DIDCT), di-iodo-chenodeoxycholyltyrosine (DICDCT), di-iodo-cholylglycyltyrosine (DICGT) and de
- In vitro anti-cryptosporidial activity of cationic peptides alone and in combination with inhibitors of ion transport systems.
- J Antimicrob Chemother. 2000 May;45(5):651-4. Unique Identifier : AIDSLINE MED/20259467
- Giacometti A; Cirioni O; Barchiesi F; Ancarani F; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Piazza Cappelli 1, 60121 Ancona, Italy.
- The anti-cryptosporidial activity of four cationic peptides alone and in combination with five ion transport system (ITS) inhibitors was investigated for six clinical isolates of Cryptosporidium parvum recovered from stools of AIDS patients. The susceptibility tests were performed by inoculating the protozoa on to cel
- Pharmacokinetics of nelfinavir and nevirapine in a patient with end-stage renal failure on continuous ambulatory peritoneal dialysis. [letter]
- J Antimicrob Chemother. 2000 May;45(5):716-7. Unique Identifier : AIDSLINE MED/20259483
- Taylor S; Little J; Halifax K; Drake S; Back D
- Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus.
- J Biol Chem. 2000 Jun 23;275(25):18946-61. Unique Identifier : AIDSLINE +
- Mummidi S; Bamshad M; Ahuja SS; Gonzalez E; Feuillet PM; Begum K; Galvis MC; Kostecki V; Valente AJ; Murthy KK; Haro L; Dolan MJ; Allan JS; Ahuja SK; Departments of Medicine, University of Texas Health Science; Center at San Antonio and South Texas Veterans Health Care; System, Audie L. Murphy Division, San Antonio, Texas 78229, USA.
- Polymorphisms in CC chemokine receptor 5 (CCR5), the major coreceptor of human immunodeficiency virus 1 (HIV-1) and simian immunodeficiency virus (SIV), have a major influence on HIV-1 transmission and disease progression. The effects of these polymorphisms may, in part, account for the differential pathogenesis of HI
- The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteins.
- J Biol Chem. 2000 Jun 23;275(25):19210-7. Unique Identifier : AIDSLINE MED/20317123
- Cristofari G; Ficheux D; Darlix JL; LaboRetro, Unite de Virologie Humaine, INSERM (412), France.
- The reverse transcription process for retroviruses and retrotransposons takes place in a nucleocore structure in the virus or virus-like particle. In retroviruses the major protein of the nucleocore is the nucleocapsid protein (NC protein), which derives from the C-terminal region of GAG. Retroviral NC proteins are fo
- The mechanism of insulin resistance caused by HIV protease inhibitor therapy.
- J Biol Chem. 2000 Jul 7;275(27):20251-4. Unique Identifier : AIDSLINE MED/20347100
- Murata H; Hruz PW; Mueckler M; Department of Cell Biology and Physiology, Department of; Pediatrics, Washington University School of Medicine, St. Louis,; Missouri 63110, USA.
- Retroviral protease inhibitors used as therapy for HIV-1 infection have been causally associated with serious metabolic side effects, including peripheral lipodystrophy, hyperlipidemia, insulin resistance, and in some cases, overt type 2 diabetes. The etiology of th
- Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus.
- J Biol Chem. 2000 Jul 7;275(27):20288-94. Unique Identifier : AIDSLINE MED/20347106
- Tachibana M; Siddiqi MA; Ikegami Y; Eshima K; Shirota-Someya Y; Tahara-Hanaoka S; Koito A; Iizuka M; Shinohara N; Department of Immunology, Mitsubishi Kasei Institute of Life; Sciences, Machida, Tokyo 194, Japan.
- Despite extensive mutational studies on the human CD4 molecule and its affinity to human immunodeficiency virus (HIV) envelope glycoprotein gp120, coreceptor functions of such mutant molecules have only been examined by indirect measurement of their affinity to class II major histocompatibility complex (MHC) molecules
- Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors.
- Unique Identifier : AIDSLINE MED/20347118
- Chen P; Flory E; Avots A; Jordan BW; Kirchhoff F; Ludwig S; Rapp UR; Institut fur Medizinische Strahlenkunde und Zellforschung,; Universitat Wurzburg, Versbacher Strasse 5, D-97078 Wurzburg,; Germany.
- To study the role of MAPK cascades in the regulation of naturally occurring human immunodeficiency virus type 1 long terminal repeats (HIV-1 LTRs), we analyzed several HIV-1 LTRs from patients at different stages of disease progression. One of these naturally occurring HIV-1 LTRs contains an insertion termed the most
- Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B.
- J Biol Chem. 2000 Jul 7;275(27):20660-6. Unique Identifier : AIDSLINE PDB/1QD3
- Faber C; Sticht H; Schweimer K; Rosch P; Lehrstuhl fur Biopolymere, Universitat Bayreuth, D-95447; Bayreuth, Germany.
- Binding of human immunodeficiency virus type 1 (HIV-1) transactivator (Tat) protein to Tat-responsive RNA (TAR) is essential for viral replication and is considered a promising starting point for the design of anti-HIV drugs. NMR spectroscopy indicated that the aminoglycosides neomycin B and ribostamycin bind to TAR a
- Is a closing "GA pair" a rule for stable loop-loop RNA complexes?
- J Biol Chem. 2000 Jul 14;275(28):21287-94. Unique Identifier : AIDSLINE MED/20347242
- Duconge F; Di Primo C; Toulme JJ; INSERM U386, Institut Federatif de Recherche Pathologies; Infectieuses, Universite Victor Segalen, 146 rue Leo Saignat,; 33076 Bordeaux cedex, France.
- RNA hairpin aptamers specific for the trans-activation-responsive (TAR) RNA element of human immunodeficiency virus type 1 were identified by in vitro selection (Duconge, F., and Toulme, J. J. (1999) RNA 5, 1605-1614). The high affinity sequences selected at physiological magnesium concentration (3 mm) were shown to f
- A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element.
- Unique Identifier : AIDSLINE GENBANK/AF199414
- Westberg C; Yang JP; Tang H; Reddy TR; Wong-Staal F
- The constitutive transport element (CTE) of type D retroviruses mediates the nuclear export of unspliced viral transcripts. We previously showed that RNA helicase A functionally interacts with CTE and contains a bidirectional nuclear transport domain at the carboxyl terminus. Here we report the identification of a nov
- Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in Vitro.
- J Biol Chem. 2000 Jul 14;275(28):21460-7. Unique Identifier : AIDSLINE MED/20347265
- Jing N; Marchand C; Liu J; Mitra R; Hogan ME; Pommier Y; Department of Molecular Physiology and Biophysics, Baylor College; of Medicine, Houston, Texas 77030, USA. njing@bcm.tmc.edu
- The G-tetrad-forming oligonucleotides and have been identified as potent inhibitors of human immunodeficiency virus type 1 integrase (HIV-1 IN) activity (Rando, R. F., Ojwang, J., Elbaggari, A., Reyes, G. R., Tinder, R., McGrath, M. S., and Hogan, M. E. (1995) J. Biol. Chem. 270, 1754-1760; Mazumder, A., Neamati, N.,
- Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells.
- J Biol Chem. 2000 Jul 14;275(28):21668-77. Unique Identifier : AIDSLINE MED/20347291
- Holloway AF; Occhiodoro F; Mittler G; Meisterernst M; Shannon MF; Division of Biochemistry and Molecular Biology, John Curtin; School of Medical Research, Australian National University,; Canberra, Australia.
- The human immunodeficiency virus (HIV) transactivator Tat is a potent activator of transcription from the HIV long terminal repeat and is essential for efficient viral gene expression and replication. Tat has been shown to interact with components of the basal transcription machinery and transcriptional activators. He
- Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells.
- Unique Identifier : AIDSLINE MED/20327717
- Montaldo F; Maffe A; Morini M; Noonan D; Giordano S; Albini A; Prat M
- Kaposi s sarcoma (KS) is the most frequent malignant lesion in patients with AIDS and is characterized by spindle cell proliferation, inflammatory cell infiltration, angiogenesis, edema, and invasiveness. KS origin is still debated. The complex aspect of this disease is probably supported by multiple concomitant patho
- Differentiating HIV-1 parotid cysts from papillary cystadenoma lymphomatosum.
- J Am Dent Assoc. 2000 Jun;131(6):772-6. Unique Identifier : AIDSLINE MED/20317910
- Mandel L; Tomkoria A; Columbia University School of Dental and Oral Surgery, New; York-Presbyterian Hospital, N.Y. 10032, USA.
- BACKGROUND: Patients with parotid cystic lesions may first be seen in the dental office. These conditions most often represent either papillary cystadenoma lymphomatosum, or PCL, or lymphoepithelial cysts associated with human immunodeficiency virus, or HIV, disease. The authors present a case report to illustrate the
- Maturity and oral health: live longer and better.
- J Am Dent Assoc. 2000 Jun;131(6):805-8. Unique Identifier : AIDSLINE MED/20317915
- Slavkin HC; National Institute of Dental and Craniofacial Research, Bethesda,; Md. 20892-2290, USA.
- The extent of undiagnosed HIV infection among emergency department patients: results of a blinded seroprevalence survey and a pilot HIV testing program.
- J Emerg Med. 2000 Jul;19(1):13-9. Unique Identifier : AIDSLINE MED/20323368
- Goggin MA; Davidson AJ; Cantril SV; O'Keefe LK; Douglas JM; Department of Public Health, Denver Health Medical Center,; Colorado 80204, USA.
- This study was performed to determine the rate of previously undiagnosed HIV infection among patients presenting to an urban emergency department (ED) and to assess the feasibility of routinely offering voluntary HIV testing in this setting. HIV serostatus was determined anonymously among consecutive acute medicine an
- Infective endocarditis in intravenous drug users: does HIV status alter the presenting temperature and white blood cell count?
- J Emerg Med. 2000 Jul;19(1):5-11. Unique Identifier : AIDSLINE MED/20323367
- Robinson DJ; Lazo MC; Davis T; Kufera JA; University of Texas-Houston Health Science Center, 77030, USA.
- The intent of this study was to determine if HIV seropositivity alters the maximum temperature (T(max)) and WBC count of febrile intravenous (i.v.) drug users with infective endocarditis (IE). A review of 497 charts of patients with endocarditis provided 228 eligible patient visits (46%), with 158 cases (69.3%) of IE
- Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis.
- J Invest Dermatol. 2000 Jul;115(1):74-80. Unique Identifier : AIDSLINE MED/20344887
- Echchakir H; Bagot M; Dorothee G; Martinvalet D; Le Gouvello S; Boumsell L; Chouaib S; Bensussan A; Mami-Chouaib F; Laboratoire Cytokines et Immunologie des tumeurs humaines, INSERM; U487, Institut Gustave Roussy, Villejuif, France.
- We have previously described two cytotoxic T lymphocyte clones isolated from lymphocytes infiltrating a human major histocompatibility complex class II-/class I+, CD4+ cutaneous T cell lymphoma. These clones displayed a CD4+CD8dim+ (TC5) and CD4+ CD8- (TC7) phenotype and mediated a specific major histocompatibility co
- Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes.
- J Invest Dermatol. 2000 Jul;115(1):81-7. Unique Identifier : AIDSLINE MED/20344888
- Albanesi C; Scarponi C; Cavani A; Federici M; Nasorri F; Girolomoni G; Laboratory of Immunology, Istituto Dermopatico dell'Immacolata,; IRCCS, Rome, Italy. c.albanesi@idi.it
- Interleukin-17 is a T-cell-derived cytokine, detected in skin affected by allergic contact dermatitis and psoriasis, which regulates keratinocyte expression of adhesion molecules and chemokines. In this study, we have analyzed whether interleukin-17 production segregates with a particular T helper (Th) cell subset, an
- Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells.
- J Leukoc Biol. 2000 Jul;68(1):9-14. Unique Identifier : AIDSLINE MED/20370150
- Yang D; Chen Q; Chertov O; Oppenheim JJ; Division of Basic Sciences, SAIC Frederick, National Cancer; Institute-Frederick cancer Research and Development Center,; Maryland 21702-1201, USA.
- Defensins, a family of cationic, structurally related, antimicrobial peptides, contribute to host defense by disrupting the cytoplasmic membrane of microbes. Here we show that human neutrophil defensins selectively induce the migration of human CD4+/CD45RA+ naive and CD8+, but not CD4+/CD45RO+ memory, T cells. Moreove
- GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells.
- J Exp Med. 2000 Jul 3;192(1):105-15. Unique Identifier : AIDSLINE MED/20341624
- Lee HJ; Takemoto N; Kurata H; Kamogawa Y; Miyatake S; O'Garra A; Arai N; Department of Immunology, DNAX Research Institute, Palo Alto,; California 94304-1104, USA.
- Committed T helper type 1 (Th1) and Th2 effector cells, resulting from chronic antigenic stimulation in interleukin (IL)-12 and IL-4, are implicated in the pathology of autoimmune and allergic diseases. Committed Th1 cells cannot be induced to change their cytokine profiles in response to antigenic stimulation and Th2
- Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1.
- J Exp Med. 2000 Jul 3;192(1):11-21. Unique Identifier : AIDSLINE MED/20341615
- Lee BS; Alvarez X; Ishido S; Lackner AA; Jung JU; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, Massachusetts 01772, USA.
- The B cell antigen receptor (BCR) is a large complex that consists of a disulfide-linked tetramer of two transmembrane heavy (mu) chains and two light (lambda or kappa) chains in association with a heterodimer of Igalpha and Igbeta. Kaposi s sarcoma-associated herpesvirus (KSHV) encodes a transforming protein called K
- Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis.
- J Exp Med. 2000 Jul 3;192(1):123-8. Unique Identifier : AIDSLINE MED/20341626
- Chu CQ; Wittmer S; Dalton DK; Trudeau Institute, Saranac Lake, New York 12983, USA.
- Mice deficient in interferon (IFN)-gamma or IFN-gamma receptor develop progressive and fatal experimental autoimmune encephalomyelitis (EAE). We demonstrate that CD4 T cells lacking IFN-gamma production were required to passively transfer EAE, indicating that they were disease-mediating cells in IFN-gamma knockout (KO
- TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation.
- J Exp Med. 2000 Jul 3;192(1):137-43. Unique Identifier : AIDSLINE MED/20341628
- Xia XZ; Treanor J; Senaldi G; Khare SD; Boone T; Kelley M; Theill LE; Colombero A; Solovyev I; Lee F; McCabe S; Elliott R; Miner K; Hawkins N; Guo J; Stolina M; Yu G; Wang J; Delaney J; Meng SY; Boyle WJ; Hsu H; Department of Inflammation, Amgen, Thousand Oaks, California; 91320-1799, USA.
- We and others recently reported tumor necrosis factor (TNF) and apoptosis ligand-related leukocyte-expressed ligand 1 (TALL-1) as a novel member of the TNF ligand family that is functionally involved in B cell proliferation. Transgenic mice overexpressing TALL-1 have severe B cell hyperplasia and lupus-like autoimmune
- Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or dependent stimuli.
- J Exp Med. 2000 Jul 3;192(1):145-50. Unique Identifier : AIDSLINE MED/20341629
- Schuurhuis DH; Laban S; Toes RE; Ricciardi-Castagnoli P; Kleijmeer MJ; van der Voort EI; Rea D; Offringa R; Geuze HJ; Melief CJ; Ossendorp F; Department of Immunohematology and Blood Transfusion, Leiden; University Medical Center, 2300 RC Leiden, The Netherlands.
- The well defined, immature murine dendritic cell (DC) line D1 was used to study the role of DC maturation in CTL induction in vitro and in vivo. Maturation of D1 cells, characterized by markedly increased expression of MHC and costimulatory molecules, was induced by incubation with lipopolysaccharide, agonistic CD40 a
- H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
- J Exp Med. 2000 Jul 3;192(1):31-40. Unique Identifier : AIDSLINE MED/20341617
- Felix NJ; Brickey WJ; Griffiths R; Zhang J; Van Kaer L; Coffman T; Ting JP; University of North Carolina Lineberger Comprehensive Cancer; Center, Department of Microbiology and Immunology, University of; North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599,; USA.
- The role played by antigenic peptides bound to major histocompatibility complex (MHC) molecules is evaluated with H2-DMalpha(-/)- mice. These mice have predominantly class II-associated invariant chain peptide (CLIP)-, not antigenic peptide-bound, MHC class II. H2-DMalpha(-/)- donor heart grafts survived three times l
- Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation.
- J Exp Med. 2000 Jul 3;192(1):41-52. Unique Identifier : AIDSLINE MED/20341618
- Kitani A; Fuss IJ; Nakamura K; Schwartz OM; Usui T; Strober W; Mucosal Immunity Section, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892, USA.
- In this study, we show that a single intranasal dose of a plasmid encoding active transforming growth factor beta1 (pCMV-TGF-beta1) prevents the development of T helper cell type 1 (Th1)-mediated experimental colitis induced by the haptenating reagent, 2,4, 6-trinitrobenzene sulfonic acid (TNBS). In addition, such pla
- Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection.
- J Exp Med. 2000 Jul 3;192(1):53-61. Unique Identifier : AIDSLINE MED/20341619
- Kopf M; Coyle AJ; Schmitz N; Barner M; Oxenius A; Gallimore A; Gutierrez-Ramos JC; Bachmann MF; Basel Institute for Immunology, 4005 Basel, Switzerland.; kopf@bii.ch
- It has been shown that certain pathogens can trigger efficient T cell responses in the absence of CD28, a key costimulatory receptor expressed on resting T cells. Inducible costimulator protein (ICOS) is an inducible costimulator structurally and functionally related to CD28. Here, we show that in the absence of CD28
- HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function.
- J Exp Med. 2000 Jul 3;192(1):63-75. Unique Identifier : AIDSLINE MED/20341620
- Appay V; Nixon DF; Donahoe SM; Gillespie GM; Dong T; King A; Ogg GS; Spiegel HM; Conlon C; Spina CA; Havlir DV; Richman DD; Waters A; Easterbrook P; McMichael AJ; Rowland-Jones SL; Medical Research Council Human Immunology Unit, Institute of; Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS,; United Kingdom.
- The use of peptide-human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8(+) T cells has provided a major development in our understanding of their role in controlling viral infections. However, questions remain about the exact function of these cells, particular
- Research on anti-HIV-1 agents. Investigation on the CD4-Suradista binding mode through docking experiments.
- J Comput Aided Mol Des. 2000 May;14(4):355-68. Unique Identifier : AIDSLINE MED/20273194
- Manetti F; Corelli F; Mongelli N; Borgia AL; Botta M; Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi; di Siena, Italy.
- Sulfonated distamycin (Suradista) derivatives exhibit anti-HIV-1 activity by inhibiting the binding of the viral envelope glycoprotein gp120 to its receptor (CD4). With the aim to propose a possible binding mode between Suradistas and the CD4 macromolecule, molecular docking experiments, followed by energy minimizatio
- Declining immune function in children and adolescents with hemophilia and HIV infection: effects on neuropsychological performance. Hemophilia Growth and Development Study.
- J Pediatr Psychol. 2000 Jul-Aug;25(5):309-22. Unique Identifier : AIDSLINE MED/20341913
- Loveland KA; Stehbens JA; Mahoney EM; Sirois PA; Nichols S; Bordeaux JD; Watkins JM; Amodei N; Hill SD; Donfield S; Department of Psychiatry and Behavioral Sciences, University of; Texas Medical School, Houston 77030, USA.; klovelnd@msi.uth.tmc.edu
- OBJECTIVE: To determine whether declines in immune functioning are associated with changes in neuropsychological performance in children and adolescents with hemophilia who are infected with the human immunodeficiency virus (HIV). METHODS: Participants were 333 males with hemophilia, ages 6-19 years at entry. A baseli
- Brief report: relationship between HIV infection and WPPSI-R performance in preschool-age children.
- J Pediatr Psychol. 2000 Jul-Aug;25(5):347-51. Unique Identifier : AIDSLINE MED/20341917
- Fishkin PE; Armstrong FD; Routh DK; Harris L; Thompson W; Miloslavich K; Levy JD; Johnson A; Morrow C; Bandstra ES; Mason CA; Scott G; University of Miami, USA.
- OBJECTIVE: To determine the neurodevelopmental effects of perinatally acquired HIV infection on children of preschool age. METHODS: Participants included 40 children infected with HIV between the ages of three and five and an equal number of noninfected controls individually matched according to ethnicity, age, sex, a
- A-form conformational motifs in ligand-bound DNA structures.
- J Mol Biol. 2000 Jul 21;300(4):819-40. Unique Identifier : AIDSLINE MED/20351466
- Lu XJ; Shakked Z; Olson WK; Department of Chemistry, Wright-Rieman Laboratories, Rutgers, the; State University of New Jersey, 610 Taylor Road, Piscataway, NJ,; 08854-8087, USA.
- Recognition and biochemical processing of DNA requires that proteins and other ligands are able to distinguish their DNA binding sites from other parts of the molecule. In addition to the direct recognition elements embedded in the linear sequence of bases (i.e. hydrogen bonding sites), these molecular agents seemingl
- Apocalypse now: HIV/AIDS in Africa exceeds the experts' worst predictions [news]
- JAMA. 2000 Aug 2;284(5):556-7. Unique Identifier : AIDSLINE MED/20379124
- Stephenson J
- Vaccine aimed at African HIV to begin trials [news]
- JAMA. 2000 Aug 9;284(6):683. Unique Identifier : AIDSLINE MED/20387443
- Stephenson J
- [Etiotropic combined therapy of HIV-infection]
- Klin Med (Mosk). 2000;78(5):13-8. Unique Identifier : AIDSLINE MED/20338410
- Rytik PG; Korzhev MO; Kucherov II; Podol'skaia IA; Sevkovskii IaI
- [Encephalitis combined with advanced vasculitis in a HIV infected woman]
- Klin Med (Mosk). 2000;78(5):53-6. Unique Identifier : AIDSLINE MED/20338422
- Popova IA; Burova NV; Trofimova TN; Tsinzerling VA; Kadyrova SN; Lifits EI; Rakhmanova AG
- Interleukin-9 receptor expression in asthmatic airways In vivo.
- Lung. 2000;178(3):149-60. Unique Identifier : AIDSLINE MED/20330286
- Bhathena PR; Comhair SA; Holroyd KJ; Erzurum SC; Department of Pulmonary and Critical Care Medicine, Lerner; Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio; 44195, USA.
- Inflammation of the airway wall is a defining feature in asthma and is likely the cause of the hyperreactivity and variable airflow limitation found in asthma. Immune response biased toward production of Th2 cytokines has been proposed as a mechanism in the pathogenesis of airway inflammation in asthma. The Th2 cytoki
- [Prevalence of HIV infection and risk behavior among drug users [letter]
- Med Clin (Barc). 2000 Apr 29;114(16):637-9. Unique Identifier : AIDSLINE MED/20306048
- Bachiller Luque P; Navarro Canadas C; Munoz Nunez P; Alvarez Hurtado AA
- A solid phase plate assay for HIV-1 genotyping.
- Mol Cell Probes. 2000 Jun;14(3):137-47. Unique Identifier : AIDSLINE MED/20318869
- Gonzalez-Villasenor LI; Wu K; Yang L; BBI-Biotech Research Laboratories, Gaithersburg, MD 20877, USA.
- A prototype solid phase plate assay (SPPA) for the detection and genotyping of HIV-1 subtypes was developed using a PCR-based capture hybridization format. Well characterized HIV-1 reference controls of known subtypes and subtype specific capture oligonucleotide probes targeting several regions of the envelope (env) g
- Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS.
- Neurology. 2000 Jul 25;55(2):192-8. Unique Identifier : AIDSLINE MED/20371003
- Balashov KE; Comabella M; Ohashi T; Khoury SJ; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital,; Harvard Medical School, Boston, MA, USA.
- BACKGROUND: MS is a chronic inflammatory disease of the CNS postulated to be a Th1 type cell-mediated autoimmune disease. There is increased interferon-gamma (IFNgamma) secretion in MS, and IFNgamma administration induces exacerbations of disease. IFNgamma expression is closely regulated by a number of cytokines produ
- Envelope-dependent transactivation by the retroviral oncoprotein v-Rel is required for efficient malignant transformation of chicken spleen cells.
- Oncogene. 2000 Jun 29;19(28):3131-7. Unique Identifier : AIDSLINE MED/20376977
- Epinat JC; Dvorin EL; Gilmore TD; Department of Biology, Boston University, Massachusetts; 02215-2406, USA.
- The retroviral oncoprotein v-Rel is a chimeric protein that has 11 helper virus-derived Envelope (Env) amino acids (aa) at its N terminus. Within these N-terminal Env aa of v-Rel there are three aa substitutions compared to the Rev-A helper virus Env. These aa substitutions have previously been shown to impart a numbe
- A social cognitive-based model for condom use among college students.
- Nurs Res. 2000 Jul-Aug;49(4):208-14. Unique Identifier : AIDSLINE MED/20383517
- Dilorio C; Dudley WN; Soet J; Watkins J; Maibach E; Department of Behavioral Sciences and Health Education, Rollins; School of Public Health, Emory University, USA.; cdi-iori@sph.emory.edu
- BACKGROUND: Social cognitive theory has been used extensively to explain health behaviors. Although the influence of one construct in this model-self-efficacy-has been well established, the role of other social cognitive constructs has not received as much attention in human immunodeficiency virus (HIV) prevention res
- The decision to cancel a preimplantation genetic diagnosis cycle.
- Prenat Diagn. 2000 Jul;20(7):564-6. Unique Identifier : AIDSLINE MED/20375147
- Santalo J; Grossmann M; Gimenez C; Marina F; Egozcue J; Marina S; Vidal F; Unitat de Biologia Cellular, Facultat de Ciencies, Universitat; Autonoma de Barcelona, 08193 Bellaterra, Spain.; Josep.Santalo@uab.es
- It has been suggested that a minimum number (six) of cumulus-oocyte complexes (COCs) should be retrieved for fertilization to offer enough chances to ensure a pregnancy after a preimplantation genetic diagnosis (PGD) procedure. Therefore a decision to cancel a PGD cycle should be adequately weighted to offer the patie
- [Pulmonary microcalcification with miliary foreign-body granulomas. Residuals of cured Pneumocystis carinii pneumonia in AIDS]
- Pathologe. 2000 May;21(3):247-9. Unique Identifier : AIDSLINE MED/20357839
- Bontikous S; Amthor MJ; Pathologisches Institut, Diakoniekrankenhaus, Rotenburg/Wumme.
- Pneumocystis carinii pneumonia (PCP) is one of the most frequent infectious lung diseases in immunocompromised patients, especially in AIDS cases. The present case report describes pulmonary miliary microcalcifications with and without foreign-body reaction in a patient with successfully treated PCP who was known to h
- [Pulmonary tuberculosis--the current radiological diagnosis of an old disease]
- Radiologe. 2000 Jun;40(6):507-17. Unique Identifier : AIDSLINE MED/20385682
- Hlawatsch A; Kauczor HU; Thelen M; Klinik und Poliklinik fur Radiologie, Johannes; Gutenberg-Universitat Mainz, Klinik fur Radiologie, Klinikum; der Universitat Mainz. hlawat@mail.uni-mainz.de
- INCIDENCE: Decreasing numbers of tuberculosis cases in the western countries have led to diminished attention towards this disease. But worldwide, tuberculosis still is the leading cause of mortality due to any one single infectious agent. In the industrialized countries, immigration, growth of low-income groups and i
- [Fungal pneumonia]
- Radiologe. 2000 Jun;40(6):518-29. Unique Identifier : AIDSLINE MED/20385683
- Heussel CP; Ullmann AJ; Kauczor HU; Klinik und Poliklinik fur Radiologie, Mainz.; heussel@mail.uni-mainz.de
- Concomitant with advances in medicine, involving the development and use of antibiotics, immunosuppressive drugs, organ/stem cell transplantation and pre-existing illnesses such as AIDS, the frequency of fungal infection has increased dramatically. These factors determine the susceptibility of the lung for an acute or
- [Macular exanthema in HIV infection]
- Schweiz Rundsch Med Prax. 2000 May 18;89(21):937-8. Unique Identifier : AIDSLINE MED/20317566
- Hansel A; Medizinische Universitats-Poliklinik, Departement Innere; Medizin, Kantonsspital Basel.
- [Solidarity against a virus]
- Rev Infirm. 1999 Apr;(48):4-6. Unique Identifier : AIDSLINE MED/20001083
- Pouvesle C; Gillion MH
- Toxoplasma encephalitis in AIDS patients in Sao Paulo during 1988 and 1991. A comparative retrospective analysis.
- Rev Inst Med Trop Sao Paulo. 2000 May-Jun;42(3):141-5. Unique Identifier : AIDSLINE MED/20347462
- Passos LN; Araujo Filho OF; Andrade Junior HF; Faculdade de Saude Publica, Universidade de Sao Paulo, Sao; Paulo, SP, Brasil.
- We conducted a retrospective analysis of Toxoplasma encephalitis patients from Instituto de Infectologia Emilio Ribas, the main AIDS hospital of Sao Paulo, Brazil , during two different stages of the HIV epidemics, in 1988 (38 patients) and 1991 (33 patients). There were AIDS-relate
- A clinical, epidemological, laboratorial, histological and ultrasonographical evaluation of anti-HCV EIA-2 positive blood donors.
- Rev Inst Med Trop Sao Paulo. 2000 May-Jun;42(3):147-52. Unique Identifier : AIDSLINE MED/20347463
- Goncales FL Jr; Stucchi RS; Pavan MH; Escanhoela CA; Yamanaka A; Magna LA; Goncales NS; Faculdade de Ciencias Medicas, Universidade Estadual de; Campinas, Campinas, Sao Paulo, Brasil.
- Between 1992 and 1997, 790 blood donors with anti-HCV EIA-2 strongly reagent (relationship between the sample optical density/cut-off > 3) detected at the blood bank serological screening, were evaluated in ambulatory environment. They were all negative for Chagas disease, syphilis, hepatitis B (HBsAg) and AIDS. Blood
- Effect of coinfection with STDs and of STD treatment on HIV shedding in genital-tract secretions: systematic review and data synthesis.
- Unique Identifier : AIDSLINE MED/20279614
- Rotchford K; Strum AW; Wilkinson D
- OBJECTIVE: To determine whether coinfection with sexually transmitted diseases (STD) increases HIV shedding in genital-tract secretions, and whether STD treatment reduces this shedding. DESIGN: Systematic review and data synthesis of cross-sectional and cohort studies meeting predefined quality criteria. MAIN OUTCOME
- Reexamining the prevalence of Chlamydia trachomatis infection among gay men with urethritis: implications for STD policy and HIV prevention activities.
- Sex Transm Dis. 2000 May;27(5):249-51. Unique Identifier : AIDSLINE MED/20279615
- Ciemins EL; Flood J; Kent CK; Shaw H; Rowniak S; Moncada J; Klausner JD; Schachter J; San Francisco Department of Public Health, STD Prevention and; Control Services, California, USA.
- BACKGROUND: Evidence of an STD-HIV interaction and the availability of noninvasive urine-based screening tests have resulted in an increased focus on chlamydial infections in men. GOAL: To evaluate the prevalence of chlamydial infections among men with urethritis at the San Francisco City Clinic (SFCC). STUDY DESIGN:
- HIV-1 infection-associated risk factors among sexually transmitted disease patients in Athens, Greece: 1990 to 1996.
- Sex Transm Dis. 2000 May;27(5):259-65. Unique Identifier : AIDSLINE MED/20279617
- Kyriakis KP; Hadjivassiliou M; University of Athens, Department of Dermatology and Venereology,; Andreas Sygros Hospital, Greece.
- OBJECTIVE: To determine trends in HIV seroprevalence and related risk factors among patients with sexually transmitted diseases (STDs) and to report the respective epidemiologic history characteristics. METHODS: A cross-sectional seroepidemiologic study conducted from 1990 to 1996 among 5,669 symptomatic STD cases was
- Incidence and predictors of reinfection with Trichomonas vaginalis in HIV-infected women.
- Sex Transm Dis. 2000 May;27(5):284-8. Unique Identifier : AIDSLINE MED/20279622
- Niccolai LM; Kopicko JJ; Kassie A; Petros H; Clark RA; Kissinger P; Louisiana State University Health Sciences Center HIV Outpatient; Program, New Orleans, USA.
- BACKGROUND AND OBJECTIVES: The presence of sexually transmitted infections (STIs) may facilitate transmission of HIV to uninfected partners. GOAL: To describe the incidence of reinfection with Trichomonas vaginalis in HIV-infected women and to assess predictors of reinfection. STUDY DESIGN: A retrospective cohort stud
- Risk factors for pelvic inflammatory disease in inner-city adolescents.
- Sex Transm Dis. 2000 May;27(5):289-91. Unique Identifier : AIDSLINE MED/20279623
- Suss AL; Homel P; Hammerschlag M; Bromberg K; Department of Pediatrics, State University of New York Health; Science Center at Brooklyn, 11203, USA.
- OBJECTIVE: To determine risk factors associated with pelvic inflammatory disease (PID) among inner-city adolescents. STUDY DESIGN: A case-control study was performed from 1994 to 1997 in an inner-city hospital. METHODS: Seventy-one adolescent girls diagnosed with PID and 52 sexually active adolescents girls without PI
- Seroprevalence and risk factors of hepatitis B, hepatitis C, and human cytomegalovirus among HIV-infected and high-risk uninfected adolescents: findings of the REACH Study. Adolescent Medicine HIV/AIDS Research Network.
- Sex Transm Dis. 2000 May;27(5):296-303. Unique Identifier : AIDSLINE MED/20279625
- Holland CA; Ma Y; Moscicki B; Durako SJ; Levin L; Wilson CM; Children's National Medical Center, Washington, DC 20010, USA.
- BACKGROUND AND OBJECTIVES: In adolescents and young adults, multiple studies have identified sexual activity and behaviors as significant risk factors for acquiring both human cytomegalovirus (HCMV) and hepatitis B virus (HBV). However, there are no reports on the prevalence or ris
- Correlation of CD4:CD8 ratio and tumour necrosis factor (TNF)alpha levels in induced sputum with bronchoalveolar lavage fluid in pulmonary sarcoidosis.
- Thorax. 2000 Aug;55(8):696-9. Unique Identifier : AIDSLINE MED/20359801
- Moodley YP; Dorasamy T; Venketasamy S; Naicker V; Lalloo UG; Respiratory Unit, Department of Medicine, University of Natal,; Private Bag 7, Congella 4013, South Africa.
- BACKGROUND: An increased CD4:CD8 lymphocyte ratio and raised cytokine levels in bronchoalveolar lavage (BAL) fluid are characteristic of pulmonary sarcoidosis. Sputum induction has been used as a non-invasive tool for investigating the airways and may be useful in investigating inflammation in patients with sarcoidosi
- Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs.
- Thorax. 2000 Aug;55(8):700-3. Unique Identifier : AIDSLINE MED/20359802
- Holt PG; Sly PD; TVW Telethon Institute for Child Health Research, Centre for; Child Health Research, The University of Western Australia,; Perth, Western Australia 6872. patrick@ichr.uwa.edu.au
- Contrasting incidence of Clostridium difficile and other enteropathogens in AIDS patients in London and Lusaka.
- Trans R Soc Trop Med Hyg. 2000 Mar-Apr;94(2):167-8. Unique Identifier : AIDSLINE MED/20355548
- Zulu I; Kelly P; Mwansa J; Veitch A; Farthing MJ; University Teaching Hospital, Zambia. zambart@zamnet.zm
- Cross-reactivity of anti-Plasmodium falciparum antibodies and HIV tests.
- Trans R Soc Trop Med Hyg. 2000 Mar-Apr;94(2):171-2. Unique Identifier : AIDSLINE MED/20355550
- Fonseca MO; Pang L; de Avila S do L; Arruk VG; Tozetto-Mendoza TR; Ferreira AW; Saes-Alquezar A; Boulos M; University of Sao Paulo, Brazil.
- Disseminated Penicillium marneffei infection in an African AIDS patient.
- Trans R Soc Trop Med Hyg. 2000 Mar-Apr;94(2):187. Unique Identifier : AIDSLINE MED/20355556
- Lo Y; Tintelnot K; Lippert U; Hoppe T; Department of Medicine, Bernhard-Nocht Institut of Tropical; Medicine, Hamburg, Germany. yingrulo@whothai.moph.go.th
- The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model.
- Virology. 2000 Jul 5;272(2):244-9. Unique Identifier : AIDSLINE MED/20334788
- Hasenkrug KJ; Dittmer U; Laboratory of Persistent Viral Diseases, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, 903 South 4th Street,; Hamilton, Montana, 59840, USA. khasenkrug@nih.gov
- Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines.
- Virology. 2000 Jul 5;272(2):257-66. Unique Identifier : AIDSLINE MED/20334790
- Platt GM; Cannell E; Cuomo ME; Singh S; Mittnacht S; Centre for Cell and Molecular Biology, The Institute of Cancer; Research, Chester Beatty Laboratories, 237 Fulham Road, London,; United Kingdom.
- The human herpesvirus 8 (HHV8/KSHV), along with certain other herpesviruses, encodes a gene with cyclin homology. Although the functional significance of the encoded cyclin is not clear at present, various lines of evidence propose a role for this cyclin in latently infected cells and possibly in the induction of tumo
- Genetic diversity of primary HIV-1 isolates and their sensitivity to antibody-mediated neutralization.
- Virology. 2000 Jul 5;272(2):326-30. Unique Identifier : AIDSLINE MED/20334796
- Gordon CJ; Delwart EL; Aaron Diamond AIDS Research Center, New York City, New York,; 10016, USA.
- Wide differences exist among primary isolates of HIV-1 in their sensitivity to antibody-mediated neutralization. While it is well documented that even short-term tissue culture amplification of HIV-1 leads to a reduction in the genetic diversity of the viral quasispecies seen in vivo, viral isolates, while relatively
- Direct measurement of CD8+ T cell responses in macaques infected with simian immunodeficiency virus.
- Virology. 2000 Jul 5;272(2):347-56. Unique Identifier : AIDSLINE MED/20334799
- Donahoe SM; Moretto WJ; Samuel RV; Marx PA; Hanke T; Connor RI; Nixon DF; Aaron Diamond AIDS Research Center, The Rockefeller University,; 455 First Avenue, New York, New York, 10016, USA.
- The simian immunodeficiency virus (SIV) macaque model system has been used extensively to study AIDS pathogenesis and to test candidate vaccines for their ability to protect against homologous or heterologous challenge with pathogenic SIV or SHIV. Recent studies suggest that stimulation of HIV-1-specific CTL responses
- In vitro processing of human immunodeficiency virus type 1 Gag virus-like particles.
- Virology. 2000 Jul 5;272(2):366-74. Unique Identifier : AIDSLINE MED/20334801
- Morikawa Y; Shibuya M; Goto T; Sano K; The Kitasato Institute, Kitasato University, Shirokane 5-9-1,; Minato-ku, Tokyo, 108-8642, Japan. ymorikawa@kitasato.or.jp
- Human immunodeficiency virus (HIV) Gag proteins are assembled into virus particles and then cleaved by the virion-associated HIV protease. Concomitant with Gag processing, doughnut-like HIV particles (the immature form) are converted to particles containing condensed cores (the mature form). Here we describe the in vi
- Inhibition of the RNA-dependent transactivation and replication of human immunodeficiency virus type 1 by a fluoroquinoline derivative K-37.
- Virology. 2000 Jul 5;272(2):402-8. Unique Identifier : AIDSLINE MED/20334805
- Okamoto H; Cujec TP; Okamoto M; Peterlin BM; Baba M; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, Nagoya, 467-8601, Japan.
- Human immunodeficiency virus type 1 (HIV-1) is unique in that it encodes its own transcriptional activator Tat, which specifically binds to the viral mRNA sequence TAR (transactivation response) element and activates viral transcription at the step of elongation as well as initiation. We recently reported that fluoroq
- The HIV-1 Env protein signal sequence retards its cleavage and down-regulates the glycoprotein folding.
- Virology. 2000 Jul 5;272(2):417-28. Unique Identifier : AIDSLINE MED/20334807
- Li Y; Luo L; Thomas DY; Kang CY; Siebens-Drake Research Institute, The University of Western; Ontario, London, Ontario, N6G 2V4, Canada.
- Secretory proteins and most membrane proteins are synthesized with a signal sequence that is usually cleaved from the nascent polypeptide chain, during its transport, into the lumen of the endoplasmic reticulum (ER). We have analyzed the kinetics of the cleavage of the HIV-1 Env protein signal sequence from gp160 and
- Anti-Gag cytolytic T lymphocytes specific for an alternative translational reading frame-derived epitope and resistance versus susceptibility to retrovirus-induced murine AIDS in F(1) mice.
- Virology. 2000 Jul 5;272(2):438-49. Unique Identifier : AIDSLINE MED/20334809
- Mayrand SM; Healy PA; Torbett BE; Green WR; Department of Microbiology, Dartmouth Medical School, One Medical; Center Drive, Lebanon, New Hampshire, 03756, USA.
- Murine AIDS (MAIDS) develops in susceptible mouse strains after infection with the LP-BM5 murine leukemia virus complex that contains causative defective, and ecotropic helper, retroviruses. We previously demonstrated that the MAIDS-resistant H-2(d) strains BALB/cByJ and C57BL/KsJ generate MHC class I (K(d)) restricte
- Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization.
- Virology. 2000 Jul 20;273(1):112-9. Unique Identifier : AIDSLINE MED/20351729
- Sandberg JK; Leandersson AC; Devito C; Kohleisen B; Erfle V; Achour A; Levi M; Schwartz S; Karre K; Wahren B; Hinkula J; Microbiology and Tumor Biology Center, Karolinska Institutet,; Stockholm, 171 77, Sweden. jsandber@adarc.adarc.org
- We investigated the immune response against a human immunodeficiency virus type 1 (HIV-1) nef DNA sequence administered epidermally in mice transgenic for the human major histocompatibility complex (MHC) class I molecule HLA-A201. Ten potential HLA-A2 binding 9-mer Nef peptides were identified by a computer-based sear
- Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.
- Virology. 2000 Jul 20;273(1):16-20. Unique Identifier : AIDSLINE MED/20351719
- Stitz J; Buchholz CJ; Engelstadter M; Uckert W; Bloemer U; Schmitt I; Cichutek K; Department of Medical Biotechnology, Paul-Ehrlich-Institut,; Langen, 63225, Germany.
- Lentiviral vectors pseudotyped with the envelope glycoproteins (Env) of amphotropic murine leukemia virus (MLV) and the G protein of vesicular stomatitis virus (VSV-G) have been successfully used in recent preclinical gene therapy studies. We report here the generation of infectious HIV-1-derived vector particles pseu
- An anti-human immunodeficiency virus multiple antigen peptide encompassing the cleavage region of the env precursor interferes with membrane fusion at a post-CD4 binding step.
- Virology. 2000 Jul 20;273(1):169-77. Unique Identifier : AIDSLINE MED/20351735
- Barbouche R; Decroly E; Kieny MP; Fenouillet E; CNRS, Faculte de Medecine Nord, Marseille, France.
- CLIV is a multiple antigen peptide ([PTKAKRRVVQREKR](4)-K(2)-K-betaA) that encompasses the cleavage region of the human immunodeficiency virus type 1 (HIV-1) envelope precursor. It displays an antiviral activity against HIV-1 and HIV-2 and inhibits HIV-1 Env-mediated cell-to-cell fusion. This effect has previously bee
- Neutralization and enhancement of HIV-1 infection by sera from HIV-1 infected individuals who progress to disease at different rates.
- Virology. 2000 Jul 20;273(1):52-9. Unique Identifier : AIDSLINE MED/20351723
- Jolly PE; Weiss HL; Department of Epidemiology and International Health, University; of Alabama, Birmingham, Alabama, 35294-0022, USA. jollyp@uab.edu
- We examined the neutralizing/enhancing activity in sera collected at an early and a later time point postinfection from 13 HIV-positive nonprogressors, 13 moderate progressors, and 13 rapid progressors to determine the relationship between neutralizing/enhancing activity and disease progression. Early sera from each g
- Protective immunity against feline immunodeficiency virus induced by inoculation with vif-deleted proviral DNA.
- Virology. 2000 Jul 20;273(1):67-79. Unique Identifier : AIDSLINE MED/20351725
- Lockridge KM; Chien M; Dean GA; Stefano Cole K; Montelaro RC; Luciw PA; Sparger EE; Departments of Medicine and Epidemiology, University of; California, Davis, California, 95616, USA.
- To determine whether live-attenuated feline immunodeficiency virus (FIV) proviral DNA will induce protective immunity, a plasmid clone constructed with a FIV provirus containing a deletion in the viral accessory gene vif (FIV-pPPR-Deltavif) was inoculated as proviral DNA into four cats by the intramuscular route. Afte
- Multicentric Castleman's disease in 2 patients with HIV infection, unresponsive to antiviral therapy.
- Acta Clin Belg. 2000 Mar-Apr;55(2):97-101. Unique Identifier : AIDSLINE MED/20338284
- Bottieau E; Colebunders R; Schroyens W; Van Droogenbroeck J; De Droogh E; Depraetere K; De Raeve H; Van Marck E; Instituut voor Tropische Geneeskunde, Departement Klinische; Wetenschappen, Antwerpen, Belgie.
- Two HIV infected patients with multicentric Castleman s disease (MCD) and Kaposi s sarcoma are reported. Both died despite combination antiretroviral therapy including protease inhibitors .
- Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series.
- Am J Surg Pathol. 2000 Aug;24(8):1047-57. Unique Identifier : AIDSLINE MED/20388688
- Guillou L; Fletcher CD; University Institute of Pathology, Lausanne, Switzerland.
- The clinicopathologic features of 12 cases of benign lymphangioendothelioma (acquired progressive lymphangioma) are reported. There were five male and seven female patients. Age at diagnosis ranged from 17 to 90 years (median age, 54 yrs). Development of a single macular/papular hemangiomatous or pigmented lesion was
- Chromatographic and immunochemical approaches to the analysis of the HIV protease inhibitor saquinavir in plasma.
- Anal Biochem. 2000 May 15;281(1):105-14. Unique Identifier : AIDSLINE MED/20304230
- Wiltshire HR; Wiltshire BG; Clarke AF; Worth E; Prior KJ; Tjia JF; Roche Discovery Welwyn, Welwyn Garden City, Hertfordshire, United; Kingdom. hugh.wiltshire@roche.com
- The development of the HIV protease inhibitor saquinavir (Ro 31-8959) required a range of analytical methods for its measurement in biological fluids. This paper describes the development of isocratic, reverse-phase HPLC/UV methods for the routine measurement of plasma levels of the drug together with a more sensitive
- Bioluminescence detection of proteolytic bond cleavage by using recombinant aequorin.
- Anal Biochem. 2000 May 15;281(1):87-94. Unique Identifier : AIDSLINE MED/20304227
- Deo SK; Lewis JC; Daunert S; Department of Chemistry, University of Kentucky, Lexington 40506,; USA.
- Detection of proteolytic bond cleavage was achieved by taking advantage of the bioluminescence emission generated by the photoprotein aequorin. A genetically engineered HIV-1 protease substrate was coupled with a cysteine-free mutant of aequorin by employing the polymerase chain reaction to produce a fusion protein th
- Characterization of the "helix clamp" motif of HIV-1 reverse transcriptase using MALDI-TOF MS and surface plasmon resonance.
- Anal Chem. 2000 Jun 1;72(11):2635-40. Unique Identifier : AIDSLINE MED/20313790
- Lin S; Long S; Ramirez SM; Cotter RJ; Woods AS; Department of Pharmacology and Molecular Sciences, The Johns; Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
- A helix-turn-helix motif in the crystal structure of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) was proposed to be a conserved nucleic acid binding domain among several nucleotide polymerizing enzymes (Hermann, T.; Meier, T.; Gotte, M.; Heumann, H. Nucleic Acids Res. 1994, 22, 4625-4633). The
- Streptococcus pneumoniae: bacteremia in an era of penicillin resistance.
- Am J Infect Control. 2000 Jun;28(3):239-43. Unique Identifier : AIDSLINE MED/20300589
- Castillo EM; Rickman LS; Brodine SK; Ledbetter EK; Kelly C; Master of Public Health Program (Epidemiology), San Diego State; University, California, USA.
- BACKGROUND: The proportion of penicillin-resistant Streptococcus pneumoniae isolates and associated risk factors varies by geographic area in the United States . We conducted a retrospective study to determine the extent of penicillin-nonsusceptible S pneumoniae bacteremia and associate
- HIV and diarrhea in the era of HAART: 1998 New York State hospitalizations.
- Am J Infect Control. 2000 Jun;28(3):262-6. Unique Identifier : AIDSLINE MED/20300593
- Anastasi JK; Capili B; Center for AIDS Research, Columbia University School of Nursing,; New York, NY 10032, USA.
- BACKGROUND: This study reflects an attempt to identify the causes of diarrheal illness in hospitalized HIV patients in light of therapeutic advancements in HIV management. METHODS: The study identifies the various etiologies associated with diarrhea among HIV patients hospitalized in New York State in 1998. Data for t
- Effect of antiretroviral therapy on HIV shedding in semen.
- Ann Intern Med. 2000 Aug 15;133(4):280-4. Unique Identifier : AIDSLINE MED/20383461
- Barroso PF; Schechter M; Gupta P; Melo MF; Vieira M; Murta FC; Souza Y; Harrison LH; Laboratorio de Pesquisas, Hospital Universitario Clementino; Fraga Filho, School of Medicine, Universidade Federal do Rio de; Janeiro, Brazil.
- BACKGROUND: The effect of antiretroviral therapy on seminal HIV shedding in the community remains unknown. OBJECTIVE: To evaluate the effect of antiretroviral therapy on HIV shedding in semen. DESIGN: Prospective cohort study. SETTING: University hospital in Rio de Janeiro, Brazil .
- Update in infectious diseases.
- Ann Intern Med. 2000 Aug 15;133(4):285-92. Unique Identifier : AIDSLINE MED/20383462
- Bartlett JG; Division of Infectious Diseases, Baltimore, MD 21205, USA.
- Induction of Th1 response by dendritic cells pulsed with autologous melanoma apoptotic bodies.
- Anticancer Res. 2000 May-Jun;20(3A):1329-36. Unique Identifier : AIDSLINE MED/20383175
- Chang JW; Peng M; Vaquerano JE; Zhou YM; Clinton RA; Hyun WC; Giedlin MA; Leong SP; Department of Surgery, University of California/Mount Zion Cancer; Center, San Francisco 94115, USA.
- BACKGROUND: We hypothesize that dendritic cells (DCs) can process antigens from autologous melanoma apoptotic bodies (MABs) and induce effector T cells in melanoma patients. MATERIALS AND METHODS: Peripheral blood mononuclear cells were obtained from three stage IV melanoma patients and adherent cells were cultured in
- An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications.
- Anticancer Res. 2000 May-Jun;20(3A):1567-75. Unique Identifier : AIDSLINE MED/20383207
- Gonzalez S; Alcaraz MV; Cuevas J; Perez M; Jaen P; Alvarez-Mon M; Villarrubia VG; Wellman Laboratories of Photomedicine, Harvard Medical School,; Boston, MA, USA.
- In the present study we show the capacity of an extract of the fern Polypodium leucotomos (PLE) to partially inhibit the production of cytokines showing a Th1 pattern ( IL-2 , IFN-gamma and TNF-alpha) in human PHA-stimulated peripheral blood mononuclear cells. The percen
- Seroprevalence of Kaposi's sarcoma-associated herpesvirus in healthy adults in Israel.
- Anticancer Res. 2000 May-Jun;20(3B):2119-22. Unique Identifier : AIDSLINE MED/20383298
- Iscovich J; Fischbein A; Fisher-Fischbein J; Freedman LS; Eng SM; Boffetta P; Vudovich A; Glasman C; Goldschmidt R; Livingston M; Heger-Maslansky B; Brennan P; Moore PS; International Fertility Institute, Ra'anana, Israel.; iscovich@netvision.net.il
- To determine if Kaposi s sarcoma-associated herpesvirus (KSHV) prevalence is correlated with the 9-fold difference in the incidence of classic Kaposi s sarcoma observed among Israeli Jewish populations, we conducted a cross-sectional KSHV seroprevalence survey in a population of 166 HIV-seronegative healthy subjects f
- Dual protease inhibitor therapy in HIV-infected patients: pharmacologic rationale and clinical benefits.
- Unique Identifier : AIDSLINE MED/20295857
- Flexner C
- HIV protease inhibitors , as components of combination antiretroviral drug regimens, have substantially reduced the morbidity and mortality associated with HIV infection. They selectively block the action of the virus-encoded protease and stop the virus from replicat
- Efficiency of erythropoietin's signal peptide for HIV(MN)-1 gp 120 expression.
- Biochem Biophys Res Commun. 2000 Jul 5;273(2):557-9. Unique Identifier : AIDSLINE MED/20334309
- Herrera AM; Musacchio A; Fernandez JR; Duarte CA; Division of Vaccines, Centro de Ingenieria Genetica y; Biotecnologia, Cdad. Habana, 10600, Cuba. amherrera@cigb.edu.cu
- The HIV-1 gp120 gene with natural signal sequence expressed in eukaryotic expression systems showed extremely low levels of synthesis and secretion. Several expression systems have been used to improve the secretion levels of gp 120. In mammalian cells, the efficient expression of gp120 fused to t-PA signal peptide ha
- Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease.
- AIDS. 2000 May 5;14(7):761-70. Unique Identifier : AIDSLINE MED/20296393
- Al-Harthi L; Siegel J; Spritzler J; Pottage J; Agnoli M; Landay A; Department of Immunology/Microbiology, Rush-Presbyterian-St.; Luke's Medical Center, Chicago, Illinois 60612, USA.
- OBJECTIVES: It is predicted that HIV-infected individuals in early HIV disease are the most likely group to achieve immune reconstitution following highly active antiretroviral treatment. We assessed whether suppression of HIV replication in this group would improve immune function. METHODS: Seventeen antiretroviral-n
- Accelerated replicative senescence of the peripheral immune system induced by HIV infection.
- AIDS. 2000 May 5;14(7):771-80. Unique Identifier : AIDSLINE MED/20296394
- Bestilny LJ; Gill MJ; Mody CH; Riabowol KT; Department of Medical Biochemistry and Oncology, The University; of Calgary Health Sciences Centre, Alberta, Canada.
- OBJECTIVES: HIV induces rapid turnover of T lymphocytes but whether this leads to replicative senescence of CD4+ and CD8+ cells and contributes to AIDS symptoms is unclear. The aim of this study was to address this question by analyzing telomere length in blood cell populations as a measure of replicative history in a
- The role of abacavir (ABC, 1592) in antiretroviral therapy-experienced patients: results from a randomized, double-blind, trial. CNA3002 European Study Team.
- AIDS. 2000 May 5;14(7):781-9. Unique Identifier : AIDSLINE MED/20296395
- Katlama C; Clotet B; Plettenberg A; Jost J; Arasteh K; Bernasconi E; Jeantils V; Cutrell A; Stone C; Ait-Khaled M; Purdon S; Hopital de la Pitie Salpetriere, Paris, France.
- OBJECTIVE: To compare the antiviral activity of abacavir (ABC) with stable background therapy (SBG) and SBG alone in antiretroviral therapy-experienced subjects as demonstrated by the proportion of subjects with plasma HIV-1 RNA
- Salvage therapy with abacavir plus a non-nucleoside reverse transcriptase inhibitor and a protease inhibitor in heavily pre-treated HIV-1 infected patients. Swiss HIV Cohort Study.
- AIDS. 2000 May 5;14(7):791-9. Unique Identifier : AIDSLINE MED/20296396
- Khanna N; Klimkait T; Schiffer V; Irigoyen J; Telenti A; Hirschel B; Battegay M; Basel Center for HIV-Research, Outpatient Department of Internal; Medicine, University of Basel, Switzerland.
- BACKGROUND: Highly active antiretroviral therapy (HAART) may fail, especially in pre-treated patients. OBJECTIVE: To examine retrospectively whether heavily pre-treated patients not responding to HAART at least once respond to a salvage therapy with abaca
- Decreased exposure to saquinavir in HIV-1-infected patients after long-term antiretroviral therapy including ritonavir and saquinavir.
- AIDS. 2000 May 5;14(7):801-5. Unique Identifier : AIDSLINE MED/20296397
- Gisolf EH; van Heeswijk RP; Hoetelmans RW; Danner SA; National AIDS Therapy Evaluation Centre, Department of Internal; Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
- OBJECTIVE: To explore whether steady-state plasma pharmacokinetics of ritonavir and saquinavir change during long-term treatment in HIV-1-infected patients on antiretroviral treatment including ritonavir and saquinavir. METHODS: The pharmacokinetics o
- Risks and benefits of replacing protease inhibitors by nevirapine in HIV-infected subjects under long-term successful triple combination therapy.
- AIDS. 2000 May 5;14(7):807-12. Unique Identifier : AIDSLINE MED/20296398
- Barreiro P; Soriano V; Blanco F; Casimiro C; de la Cruz JJ; Gonzalez-Lahoz J; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.
- OBJECTIVE: To analyse the safety and efficacy of replacing the protease inhibitor (PI) by nevirapine (NVP) in subjects experiencing a long-term control of virus replication under a triple PI-containing antiretroviral combination. DESIGN: Prospective e
- Viral genetic heterogeneity in HIV-1-infected individuals is associated with increasing use of HAART and higher viremia.
- AIDS. 2000 May 5;14(7):813-9. Unique Identifier : AIDSLINE MED/20296399
- Ross L; Johnson M; DeMasi R; Liao Q; Graham N; Shaefer M; St. Clair M; Department of Virology, Glaxo Wellcome Inc., Research Triangle; Park, North Carolina, 27709, USA. llr8156@glaxowellcome.com
- OBJECTIVE: To assess the correlation between the outgrowth of mutant viruses (viral genetic heterogeneity), highly active antiretroviral therapy (HAART), and plasma HIV-1 RNA in a population-based observational cohort study. DESIGN: The study population consisted of 42 HIV-1-infected individuals receiving at least two
- Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy.
- AIDS. 2000 May 5;14(7):821-6. Unique Identifier : AIDSLINE MED/20296400
- O'Brien TR; McDermott DH; Ioannidis JP; Carrington M; Murphy PM; Havlir DV; Richman DD; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland, USA. obrient@exchange.nih.gov
- BACKGROUND: Both the natural history of HIV infection and the response to antiretroviral therapy are heterogeneous. Polymorphisms in chemokine receptor genes modulate the natural history of HIV-1 infection. In comparison with subjects with other genotypes, the prognosis for HIV-1-infected CCR5-delta32 heterozygotes is
- Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase. GISCA. Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS.
- AIDS. 2000 May 5;14(7):827-38. Unique Identifier : AIDSLINE MED/20296401
- Barbaro G; Di Lorenzo G; Soldini M; Giancaspro G; Grisorio B; Pellicelli AM; D'Amati G; Barbarini G; Department of Emergency Medicine, University La Sapienza, Rome,; Italy.
- OBJECTIVE: To define whether the development of encephalopathy influences the clinical course of HIV-associated cardiomyopathy (HIV-DCM) in relation to the myocardial expression of tumour necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). DESIGN: Prospective study. SETTING: University hospit
- Efficacy and safety of combination therapy with interferon-alpha2b and ribavirin for chronic hepatitis C in HIV-infected patients.
- AIDS. 2000 May 5;14(7):839-44. Unique Identifier : AIDSLINE MED/20296402
- Landau A; Batisse D; Van Huyen JP; Piketty C; Bloch F; Pialoux G; Belec L; Petite JP; Weiss L; Kazatchkine MD; Department of Hepatology and Gastroenterology, Hopital; Broussais, Paris, France.
- OBJECTIVES: To evaluate the efficacy and safety of a combination therapy of interferon-alpha2b (IFN) and ribavirin for the treatment of chronic hepatitis C in HIV-seropositive patients. DESIGN: Open prospective trial. METHODS: Twenty patients co-infected with hepatitis
- Amphotericin B oral suspension for fluconazole-refractory oral candidiasis in persons with HIV infection. Adult AIDS Clinical Trials Group Study Team 295.
- AIDS. 2000 May 5;14(7):845-52. Unique Identifier : AIDSLINE MED/20296403
- Fichtenbaum CJ; Zackin R; Rajicic N; Powderly WG; Wheat LJ; Zingman BS; Washington University School of Medicine, St Louis, Missouri,; USA. carl.fichtenbaum@uc.edu
- OBJECTIVE: To determine the efficacy and safety of amphotericin B oral suspension (ABOS) for the treatment of fluconazole refractory oral candidiasis in persons with HIV infection. DESIGN AND SETTING: A prospective, multicenter, open label trial at 25 study centers within the AIDS Clinical Trials Group. PATIENTS AND M
- CD4 cell counts in adults with newly diagnosed HIV infection: results of surveillance in England and Wales, 1990-1998. CD4 Surveillance Scheme Advisory Group.
- AIDS. 2000 May 5;14(7):853-61. Unique Identifier : AIDSLINE MED/20296404
- Gupta SB; Gilbert RL; Brady AR; Livingstone SJ; Evans BG; PHLS AIDS and STD Centre, Communicable Disease Surveillance; Centre, London, UK.
- OBJECTIVES: To describe the distribution and changes in CD4 cell counts (both initial and subsequent) in HIV-infected persons over time and determine the factors influencing these counts. DESIGN: Reports were requested from laboratories measuring CD4 cell counts in England and Wales. Initial counts were analysed and m
- Serum albumin as a predictor of survival in HIV-infected women in the Women's Interagency HIV study.
- AIDS. 2000 May 5;14(7):863-70. Unique Identifier : AIDSLINE MED/20296405
- Feldman JG; Burns DN; Gange SJ; Bacchetti P; Cohen M; Anastos K; Nowicki M; Delapena R; Miotti P; Department of Preventive Medicine, State University of New York,; Brooklyn 11203, USA. jfeldman@netmail.hscbklyn.edu
- BACKGROUND: The level of serum albumin is associated with mortality in a wide variety of chronic diseases. However, few studies have examined the relationship between serum albumin and survival in HIV-1 infection. OBJECTIVES: To determine whether the serum albumin level is associated with survival in HIV-1 infected wo
- Trends in HIV seroprevalence among patients with sexually transmitted diseases in 17 European sentinel networks, 1990-1996. European Study Group.
- Unique Identifier : AIDSLINE MED/20296406
- Batter V; Scientific Institute of Public Health-Louis Pasteur, Brussels,; Belgium.
- OBJECTIVE: To monitor trends in HIV seroprevalence among sentinel populations of patients with new sexually transmitted disease episodes in 17 networks of 15 European countries. METHODS: Time trends were estimated by logistic regression for homo-/bisexual men, injecting drug users (IDU) and non-IDU heterosexuals. The
- A decade of HIV/AIDS prevention in Sweden: changes in attitudes associated with HIV and sexual risk behaviour from 1987 to 1997.
- AIDS. 2000 May 5;14(7):881-90. Unique Identifier : AIDSLINE MED/20296407
- Herlitz CA; Steel JL; Dalarna Research Institute, Falun, Sweden.
- OBJECTIVE: The objective of the present study was to monitor the changes in determinants of HIV-related attitudes and behaviour over a 10 year period. DESIGN/METHODS: In the past decade, over 11,000 individuals in Sweden participated in this repeated cross-sectional study to assess
- CD8 T cell anti-HIV activity as a complementary protective mechanism in vaccinated chimpanzees [letter]
- AIDS. 2000 May 5;14(7):893-4. Unique Identifier : AIDSLINE MED/20296408
- Leno M; Kowalski M; Robert-Guroff M
- Stromal-derived factor-1 chemokine gene variant is associated with the delay of HIV-1 disease progression in two longitudinal cohorts [letter]
- AIDS. 2000 May 5;14(7):894-6. Unique Identifier : AIDSLINE MED/20296409
- Dezzutti CS; Guenthner PC; Green TA; Cohen OJ; Spira TJ; Lal RB
- HIV transmission between two siblings in Africa [letter]
- AIDS. 2000 May 5;14(7):896-7. Unique Identifier : AIDSLINE MED/20296410
- Orth H; Engelbrecht S; Cotton MF; Robson BA; Smith TL; Schaaf HS; Leibrandt B; Dobbels E; van Rensburg EJ
- Widespread circulation of a B/F intersubtype recombinant form among HIV-1-infected individuals in Buenos Aires, Argentina [letter]
- AIDS. 2000 May 5;14(7):897-9. Unique Identifier : AIDSLINE MED/20296411
- Thomson MM; Villahermosa ML; Vazquez-de-Parga E; Cuevas MT; Delgado E; Manjon N; Medrano L; Perez-Alvarez L; Contreras G; Carrillo MG; Salomon H; Najera R
- Valproic acid induces human herpesvirus 8 lytic gene expression in BCBL-1 cells [letter]
- AIDS. 2000 May 5;14(7):899-902. Unique Identifier : AIDSLINE MED/20296412
- Shaw RN; Arbiser JL; Offermann MK
- Antiretroviral drug removal by haemodialysis [letter]
- AIDS. 2000 May 5;14(7):902-3. Unique Identifier : AIDSLINE MED/20296413
- Taburet AM; Gerard L; Legrand M; Aymard G; Berthelot JM
- Protease inhibitor therapy-associated lipodystrophy, hypertriglyceridaemia and diabetes mellitus [letter]
- AIDS. 2000 May 5;14(7):903-5. Unique Identifier : AIDSLINE MED/20296414
- Paparizos VA; Kyriakis KP; Botsis C; Papastamopoulos V; Hadjivassiliou M; Stavrianeas NG
- Lipodystrophy and long-term therapy with nucleoside reverse transcriptase inhibitors [letter]
- AIDS. 2000 May 5;14(7):905-6. Unique Identifier : AIDSLINE MED/20296415
- Moreno S; Martinez E
- Detection of drug resistance associated mutations in HIV primary infection within the UK [letter]
- AIDS. 2000 May 5;14(7):906-8. Unique Identifier : AIDSLINE MED/20296416
- Pillay D; Cane PA; Shirley J; Porter K
- Maternal vitamin A status and mother-to-child transmission of HIV in West Africa. DITRAME Study Group [letter]
- AIDS. 2000 May 5;14(7):908-10. Unique Identifier : AIDSLINE MED/20296417
- Castetbon K; Manigart O; Bonard D; Thomas MJ; Dumon MF; Malvy D; Van de Perre P; Dabis F
- Polymerase chain reaction on sputum for the diagnosis of pulmonary toxoplasmosis in AIDS patients [letter]
- AIDS. 2000 May 5;14(7):910-1. Unique Identifier : AIDSLINE MED/20296418
- Abraham B; Tamby I; Reynes J; Bastien P
- Neuropsychological evaluation of neurologically asymptomatic HIV-infected children.
- Brain Cogn. 2000 Jun-Aug;43(1-3):49-52. Unique Identifier : AIDSLINE MED/20313804
- Bisiacchi PS; Suppiej A; Laverda A; Department of General Psychology, Padova, Italy.
- Forty-two children born to HIV positive mothers (29 infected at different stages of the disease, according to the Disease Control Classification Centers, and 13 noninfected) underwent evaluation using a battery of neuropsychological tests. Executive function impairments were present in all infected children, whereas m
- L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
- Biochemistry. 2000 Aug 1;39(30):8698-704. Unique Identifier : AIDSLINE MED/20374548
- Shearman MS; Beher D; Clarke EE; Lewis HD; Harrison T; Hunt P; Nadin A; Smith AL; Stevenson G; Castro JL; Department of Molecular Biology, Merck Sharp & Dohme Research; Laboratories, The Neuroscience Research Centre, Terlings Park,; Harlow, Essex CM20 2QR, England. Mark_Shearman@Merck.com
- Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer s disease (AD). Elevated levels of A beta(42) peptide formation have been linked to early-onset familial AD-causing gene mutations in the amyloid beta-protein precursor (A beta PP) and the
- Probing the S1/S1' substrate binding pocket geometry of HIV-1 protease with modified aspartic acid analogues.
- Biochemistry. 2000 Aug 1;39(30):8768-81. Unique Identifier : AIDSLINE MED/20374556
- Short GF 3rd; Laikhter AL; Lodder M; Shayo Y; Arslan T; Hecht SM; Departments of Chemistry and Biology, University of Virginia,; Charlottesville, Virginia 22901, USA.
- Aspartates 25 and 125, the active site residues of HIV-1 protease, participate functionally in proteolysis by what is believed to be a general acid-general base mechanism. However, the structural role that these residues may play in the formation and maintenance of the neighboring S1/S1 substrate binding pockets rema
- Women and HIV--revisited ten years on.
- Int J STD AIDS. 2000 May;11(5):277-83. Unique Identifier : AIDSLINE MED/20283076
- Shah R; Bradbeer C; Department of Genito-Urinary Medicine, St Thomas' Hospital,; London, UK.
- This article compares how women and their relationship to HIV has changed since the original publication of this article in 1990. The number of women infected with HIV has continued to rise, but, in contrast, there have been few changes in their management. We review transmission risks and manifestations of the infect
- Rectal gonorrhoea in homosexual men: source of infection.
- Int J STD AIDS. 2000 May;11(5):284-7. Unique Identifier : AIDSLINE MED/20283077
- McMillan A; Young H; Moyes A; Department of Genitourinary Medicine, Edinburgh Royal Infirmary; NHS Trust, UK.
- The objective of this retrospective study was to determine the possible source of infection in homosexual men with rectal gonorrhoea: the probable source of rectal gonorrhoea was identified in 46/155 cases. Although the urethra was the site of infection in 33 (72%) of these contacts, only pharyngeal gonorrhoea was ide
- Enzywell recombinant enzyme immunoassay for the serological diagnosis of syphilis.
- Int J STD AIDS. 2000 May;11(5):288-91. Unique Identifier : AIDSLINE MED/20283078
- Young H; Aktas G; Moyes A; Department of Medical Microbiology, Edinburgh University Medical; School, UK. hugh.young@ed.ac.uk
- The aim of this study was to evaluate Enzywell TP, a new rapid enzyme immunoassay (EIA) that uses 2 recombinant Treponema pallidum antigens for the serological diagnosis of syphilis. Specificity was evaluated by screening 1055 unselected bloods requesting serological tests for syphilis in parallel with Enzywell TP and
- Mycoplasma genitalium in non-gonococcal urethritis--a study in Swedish male STD patients.
- Int J STD AIDS. 2000 May;11(5):292-6. Unique Identifier : AIDSLINE MED/20283079
- Bjornelius E; Lidbrink P; Jensen JS; Department of Dermatovenereology, Huddinge University Hospital,; Karolinska Institutet, Sweden.
- Urethral swab specimens obtained from 101 men attending an STD clinic were examined for the presence of Mycoplasma genitalium by polymerase chain reaction (PCR) amplification. Fifty patients had non-gonococcal urethritis (NGU), and 51 patients were included as controls without urethritis. M. genitalium DNA was detecte
- The ultrasound investigation of scrotal swelling.
- Int J STD AIDS. 2000 May;11(5):297-302. Unique Identifier : AIDSLINE MED/20283080
- Micallef M; Torreggiani WC; Hurley M; Dinsmore WW; Hogan B; Department of Radiology, Altnagelvin Hospital, Londonderry,; Northern Ireland. michaelmicallef@hotmail.com
- The objectives of this study were to: (1) establish the causes of scrotal swelling in the hospital catchment population; (2) define the role of high frequency ultrasound examination in the management of scrotal swelling. A retrospective study of 582 patients who had high frequency ultrasound examination was carried ou
- Uptake of HIV testing and treatment in an isolated population with access to free and universal healthcare.
- Unique Identifier : AIDSLINE MED/20283081
- Gillieatt SJ; Mallal SA; Department of General Practice, University of Western Australia,; Fremantle Hospital, Australia. rgilliea@cc.curtin.edu.au
- This Western Australian study analysed clinical information from 344 people with AIDS, and experiential data from a sample of 36 people with AIDS to investigate 2 relevant issues: the timing of HIV testing and uptake and experiences of HIV drug treatment. We found that the proportion of people presenting with AIDS bef
- Sexually transmitted infections and use of sexual health services among young Australian women: women's health Australia study.
- Int J STD AIDS. 2000 May;11(5):313-23. Unique Identifier : AIDSLINE MED/20283082
- Schofield MJ; Minichiello V; Mishra GD; Plummer D; Savage J; School of Health, University of New England, Armidale, New South; Wales, Australia.
- Our objective was to examine associations between self-reported sexually transmitted infections (STIs) and sociodemographic, lifestyle, health status, health service use and quality of life factors among young Australian women; and their use of family planning and sexual health clinics and associations with health, de
- Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden.
- Int J STD AIDS. 2000 May;11(5):324-6. Unique Identifier : AIDSLINE MED/20283083
- Johannisson G; Enstrom Y; Lowhagen GB; Nagy V; Ryberg K; Seeberg S; Welinder-Olsson C; Department of Dermatology and Venereology, Sahlgrenska University; Hospital, Goteborg, Sweden.
- Two hundred and thirty-three men and 85 women visiting STD clinics in western Sweden between April 1997 and March 1998 were examined for Mycoplasma genitalium and Chlamydia trachomatis. The bacteria were identified by the polymerase chain reaction (PCR) technique. Three women (3.5%
- Epidemiology of syphilis in Hungary between 1952 and 1996.
- Int J STD AIDS. 2000 May;11(5):327-33. Unique Identifier : AIDSLINE MED/20283084
- Varkonyi V; Tisza T; Horvath A; Takacsy T; Berecz M; Kulcsar G; Sardy M; National Institute of Dermato-Venereology, Semmelweis University; of Medicine, Budapest, Hungary.
- Trends in morbidity from syphilis in Hungary between 1952 and 1996 were analysed. The incidence of syphilis/100,000 inhabitants declined rapidly owing to the public health and therapeutic measures of the early 1950s (1952: total=73.
- Amyl nitrite induced acute haemolytic anaemia in HIV-antibody positive man.
- Int J STD AIDS. 2000 May;11(5):334-5. Uni