2000
- 2',3'-Didehydro-3'-deoxythymidine N-methyl-2-pyrrolidone solvate (D4T.NMPO).
- Acta Crystallogr C. 2000 May;56 ( Pt 5):580-1. Unique Identifier : AIDSLINE MED/20310174
- Viterbo D; Milanesio M; Pomez Hernandez R; Rodriquez Tanty C; Colas Gonzalez I; Sablon Carrazana M; Duque Rodriguez J; Dipartimento di Scienze e Tecnologie Avanzate, Universita del; Piemonte Orientale A. Avogadro, Alessandria, Italy.; viterbo@ch.unito.it
- Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
- Phytochemistry. 2000 Mar;53(6):689-97. Unique Identifier : AIDSLINE MED/20208671
- Zhou P; Takaishi Y; Duan H; Chen B; Honda G; Itoh M; Takeda Y; Kodzhimatov OK; Lee KH; Faculty of Pharmaceutical Sciences, University of Tokushima,; Japan.
- The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the is
- Drug treatment of HIV associated neuropsychiatric syndromes.
- Neurologia. 2000 Apr;15(4):164-71. Unique Identifier : AIDSLINE MED/20306239
- Ayuso Mateos JL; Singh AN; Catalan J; Clinical and Social Psychiatry Research Unit, Hospital; Universitario Marques de Valdecilla, Universidad de Cantabria,; Santander. ayusoj@medi.unican.es
- Psychotropic drugs are frequently used to treat the wide range of neuropsychiatric syndromes that patients infected with the human immunodeficiency virus (HIV) may develop. In order to administer these agents properly, physicians should take into account, among other factors, that: the central nervous system (CNS) of
- Do people attending a same day testing clinic discuss their need for a HIV test with their GP?
- Br J Gen Pract. 1999 Oct;49(447):813-5. Unique Identifier : AIDSLINE MED/20343501
- Madge S; Jones M; Mocroft A; Wells H; Johnson MA; Department of Thoracic Medicine, Royal Free Hospital, London.
- In the United Kingdom , people with HIV infection present with advanced disease and general practitioners (GPs) are currently an underused resource for HIV testing. We describe the reasons for using an open-access clinic rather than primary care for testing for HIV. People attending the
- [HIV-related thrombocytopenias]
- Ann Ital Med Int. 2000 Jan-Mar;15(1):20-7. Unique Identifier : AIDSLINE MED/20301705
- Mannucci PM; Gringeri A; Dipartimento di Medicina Interna, Centro Emofilia e Trombosi; Angelo Bianchi Bonomi, Universita degli Studi di Milano.; piermannuccio.mannucci@unimi.it
- Thrombocytopenia is a relatively frequent hematological complication in patients infected with the human immunodeficiency virus type 1. Occurring in all risk groups (homosexuals, intravenous drug addicts, hemophiliacs, heterosexuals) this complication has an overall prevalence varying between 5 and 15%. Only a relativ
- Lymphocyte subset abnormalities in multitransfused HIV-negative haemophilia A patients are not due to chronic hepatitis C virus infection.
- Br J Haematol. 2000 Jun;109(3):529-33. Unique Identifier : AIDSLINE MED/20345404
- Meijer K; Van Der Meer J; Smit JW; Verspiek SP; Haagsma EB; Smid WM; Division of Thrombosis, Haemostasis and Rheology, University; Hospital Groningen, The Netherlands. k.meijer@int.azg.nl
- Several abnormalities of immune parameters have been described in HIV-negative haemophiliacs, including changes in numbers of T4 and T8 cells, T4/T8 ratio and numbers of activated T cells. To assess the contribution of hepatitis C to these abnormalities, we compared lymphocyte subsets in 20 HIV-negative HCV-positive h
- Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome.
- Br J Haematol. 2000 Jun;109(3):540-8. Unique Identifier : AIDSLINE MED/20345407
- Roufosse F; Schandene L; Sibille C; Willard-Gallo K; Kennes B; Efira A; Goldman M; Cogan E; Department of Internal Medicine and Immunology, Hopital Erasme,; Universite Libre de Bruxelles, Belgium.
- Idiopathic hypereosinophilic syndrome (HES) and Gleich s syndrome are related disorders characterized by persistent or recurrent hypereosinophilia of unknown origin. Elevated IgE levels and polyclonal hypergammaglobulinaemia are considered as markers of benign outcome in this setting as they are generally associated w
- Essential role for T cells in human B-cell lymphoproliferative disease development in severe combined immunodeficient mice.
- Br J Haematol. 2000 Jun;109(3):600-10. Unique Identifier : AIDSLINE MED/20345415
- Johannessen I; Asghar M; Crawford DH; Department of Medical Microbiology, The University of Edinburgh; Medical School, UK.
- Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease (BLPD)-like lesions develop in severe combined immunodeficient (SCID) mice inoculated with peripheral blood mononuclear cells (PBMCs) from EBV-seropositive donors. We used this model to investigate the pathogenesis of EBV-associated BLPD. Tumour inci
- Absence of human herpesvirus 8 DNA sequences in leucapheresis products and bone marrow samples Of patients with advanced multiple myeloma [letter; comment]
- Br J Haematol. 2000 Jun;109(3):676-7. Unique Identifier : AIDSLINE MED/20345434
- Beck R; Neipel F; Canji B; Hebart H; Kanz L; Jahn G; Einsele H
- Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide.
- Bioconjug Chem. 2000 May-Jun;11(3):301-5. Unique Identifier : AIDSLINE MED/20281353
- Bhorade R; Weissleder R; Nakakoshi T; Moore A; Tung CH; Center for Molecular Imaging Research, Massachusetts General; Hospital, Harvard Medical School, 149 13th St., #5406,; Charlestown, Massachusetts 02129, USA.
- A major obstacle to using paramagnetic MR contrast agents for in vivo cell tracking or molecular sensing is their generally low cellular uptake. In this study, we show that a paramagnetically labeled DOTA chelator derivatized with a 13-mer HIV-tat peptide is efficiently internalized into mammalian cells. Intracellular
- The stability of intracellular zidovudine and its anabolites in extracts of peripheral blood mononuclear cells (PBMCs).
- J Pharm Biomed Anal. 2000 Apr;22(3):597-603. Unique Identifier : AIDSLINE MED/20227443
- Thevanayagam LN; Jayewardene AL; Gambertoglio JG; Department of Clinical Pharmacy, School of Pharmacy, University; of California, San Francisco 94143-0622, USA.
- Human herpes virus-8 associated with two cases of primary-effusion lymphoma.
- Ann Hematol. 2000 Jun;79(6):336-9. Unique Identifier : AIDSLINE MED/20356793
- Niitsu N; Chizuka A; Sasaki K; Umeda M; First Department of Internal Medicine, Toho University School of; Medicine, Tokyo, Japan. nniitsu@med.toho-u.ac.jp
- Primary-effusion lymphoma (PEL) is a rare form of non-Hodgkin s lymphoma which predominantly occurs in patients with acquired immunodeficiency syndrome and is characterized by the presence of a malignant effusion in one or more of the body cavities, generally in the absence of a pr
- Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children.
- Nutrition. 2000 Jun;16(6):447-53. Unique Identifier : AIDSLINE MED/20329813
- Decsi T; Koletzko B; Division of Metabolic Disorders and Nutrition, Department of; Pediatrics, Dr. von Haunersches Kinderspital, Ludwig-Maximilians; University, Munich, Germany.
- This report summarizes data on the availability of essential fatty acids (EFAs) and their long-chain polyunsaturated fatty acid (LCPUFA) metabolites in protein-energy malnutrition (PEM), in human immunodeficiency virus-1 (HIV-1) infection for which less information is available, and the combination of both PEM and HIV
- [Compared characteristics of peripheral facial paralysis according to HIV status in Bobo-Dioulasso (Burkina Faso)]
- Bull Soc Pathol Exot. 2000 Apr;93(2):104-7. Unique Identifier : AIDSLINE MED/20321951
- Millogo A; Ki-Zerbo GA; Sawadogo AB; Ouedraogo I; Tamini MM; Service de medecine interne, Centre hospitalier national Souro; Sanou, Burkina Faso. athanase_millogo@hotmail.com
- Facial paralysis is a well-described manifestation of HIV infection. We report 27 cases of peripheral facial paralysis observed at Bobo-Dioulasso Hospital in a prospective study over a period of 9 months: 55 of the cases were HIV positive and 12/15 (80%) were in the 20-39 age group. Nine out of 11 females and 6 out of
- Estimating the prevalence of problem drug use in inner London: a discussion of three capture-recapture studies.
- Addiction. 1999 Nov;94(11):1653-62. Unique Identifier : AIDSLINE MED/20349926
- Hickman M; Cox S; Harvey J; Howes S; Farrell M; Frischer M; Stimson G; Taylor C; Tilling K; Centre for Research on Drugs and Health Behaviour, Imperial; College School of Medicine, London, UK. m.hickman@ic.ac.uk
- AIMS: To provide an evidence base of estimates of the prevalence of problem drug use in inner London. DESIGN: Re-analysis of three capture-recapture studies using subjects aged 15-49 years, that aim to estimate the hidden population from analysing the overlaps between three data sources. SETTING: Newham (1995) Camden
- Human herpesviruses in primary ocular lymphoma.
- Leuk Lymphoma. 2000 Apr;37(3-4):361-5. Unique Identifier : AIDSLINE MED/20214661
- Daibata M; Komatsu T; Taguchi H; Department of Medicine, Kochi Medical School, Japan.; daibatam@kochi-ms.ac.jp
- Several human lymphotropic herpesviruses have been found in certain lymphoproliferative disorders and implicated as possible etiologic factors or as modulating elements of the diseases. To assess a possible association of the human herpesviruses with lymphomas arising from mucosa-associated lymphoid tissue (MALT), we
- Association of EBV strains, defined by multiple loci analyses, in non-Hodgkin lymphomas and reactive tissues from HIV positive and HIV negative patients.
- Leuk Lymphoma. 2000 Apr;37(3-4):425-9. Unique Identifier : AIDSLINE MED/20214668
- Gutierrez MI; Kingma DW; Sorbara L; Tran M; Raffeld M; Jaffe ES; Magrath I; Bhatia K; Lymphoma Biology Section, Pediatric Branch, Division of Clinical; Sciences, National Cancer Institute, NIH, Bethesda, MD, USA.
- Epstein-Barr virus (EBV) associated with lymphoid neoplasms demonstrates preferential association with certain viral strains. Previous subtyping studies have however been confined to analysis of sequence variability within a single locus in EBV. Variations have now been reported for several latently expressed EBV gene
- Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma.
- Am J Respir Crit Care Med. 2000 Jun;161(6):1790-6. Unique Identifier : AIDSLINE MED/20311398
- Magnan AO; Mely LG; Camilla CA; Badier MM; Montero-Julian FA; Guillot CM; Casano BB; Prato SJ; Fert V; Bongrand P; Vervloet D; UPRES 2050, Groupe de Recherche Clinique "Pathologie respiratoire; et cutanee liee a l'environnement," Service de; Pneumo-Allergologie, et Centre d'Investigations Cliniques,; INSERM, Assistance Publique Hopitaux de Marseille, France.; amagnan@mail.ap-hm.fA
- Atopy is characterized by an immune system that is biased to T helper cell, type 2 (Th2) activation. This condition predisposes to asthma, a disease in which a Th2 activation was found in blood and lungs. However, most blood studies have considered purified cells, which might give an incomplete view of immune reaction
- New therapies for heart failure: is thalidomide the answer?
- QJM. 2000 May;93(5):305-11. Unique Identifier : AIDSLINE MED/20286658
- Davey PP; Ashrafian H; Nuffield Department of Medicine, Oxford University, John; Radcliffe Hospital, Oxford, UK. patrick.davey@ndm.ox.ac.uk
- The syndrome of advanced heart failure is associated with considerable morbidity and mortality. Ideas about the reasons for the progressive nature of the heart failure syndrome have changed over the years, with the initial view that progression was principally due to pump failure (the haemodynamic hypothesis), givin
- Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo.
- Immunity. 2000 Jun;12(6):643-52. Unique Identifier : AIDSLINE MED/20350662
- Agarwal S; Avni O; Rao A; Department of Pathology, Harvard Medical School and the Center; for Blood Research, Boston, Massachusetts 02115, USA.
- By DNase I hypersensitivity analysis, we have identified an inducible, cyclosporin A-sensitive enhancer located 3 of the interleukin-4 (IL-4) gene. The enhancer binds the Th2-specific transcription factor GATA3 in vivo but is not perceptibly influenced by the absence of a second Th2-specific factor, cMaf. The antigen
- Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States.
- J Viral Hepat. 2000 May;7(3):196-202. Unique Identifier : AIDSLINE MED/20307922
- Blatt LM; Mutchnick MG; Tong MJ; Klion FM; Lebovics E; Freilich B; Bach N; Smith C; Herrera J; Tobias H; Conrad A; Schmid P; McHutchison JG; National Genetics Institute, Los Angeles, CA, USA.
- Hepatitis C virus (HCV) RNA status and HCV genotype have become important tools in the diagnosis and monitoring of therapy in chronic HCV infection. To establish a database with respect to HCV genotype and serum HCV RNA concentrations in chronic hepatitis C patients in the United States
- Comparison between three quantitative assays in patients with chronic hepatitis C and their relevance in the prediction of response to therapy.
- J Viral Hepat. 2000 May;7(3):203-10. Unique Identifier : AIDSLINE MED/20307923
- Pradat P; Chossegros P; Bailly F; Pontisso P; Saracco G; Sauleda S; Thursz M; Tillmann H; Vlassopoulou H; Alberti A; Braconier JH; Esteban JI; Hadziyannis S; Manns M; Rizzetto M; Thomas HC; Tr:epo C; Department of Hepatology, H^otel-Dieu, Lyon, France.
- To compare three quantitative assays measuring viral load in patients with chronic hepatitis C and to determine their value in predicting response to interferon (IFN) therapy, we analysed serum from 896 patients from eight European Centres using QUANTIPLEXtrade mark bDNA, MONITOR AMPLICORtrade mark and SUPERQUANTtrade
- Pretreatment symptoms and dosing regimen predict side-effects of interferon therapy for hepatitis C.
- J Viral Hepat. 2000 May;7(3):211-7. Unique Identifier : AIDSLINE MED/20307924
- Cotler SJ; Wartelle CF; Larson AM; Gretch DR; Jensen DM; Carithers Jr RL; RUSH-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612,; USA. scotler@rush.edu
- We analysed data from a multicentre interferon (IFN) treatment trial to evaluate symptoms in patients with chronic hepatitis C and to identify factors that might predict development of debilitating IFN side-effects. Two hundred and twenty-two patients (120 US, 102 French) received 3 or 5 million units (MU) of IFN-alph
- Interferon treatment with or without oral ganciclovir in HBeAg-negative chronic hepatitis B: a randomized study.
- J Viral Hepat. 2000 May;7(3):235-40. Unique Identifier : AIDSLINE MED/20307928
- Hadziyannis S; Alexopoulou A; Papakonstantinou A; Petraki K; Manesis E; Academic Department of Medicine, Hippokration General Hospital,; Athens, Greece. hadziyannis@ath.forthnet.gr
- The treatment of HBeAg-negative chronic hepatitis B with alpha interferon alone is unsatisfactory. We evaluated the efficacy of combined administration of interferon-a2a (IFN) with oral ganciclovir, a nucleoside analogue. Forty patients with hepatitis B virus (HBV)-DNA-positive/HBeAg-negative chronic hepatitis B, were
- Industry outlines its perspective on new third-world vaccine development [news]
- Nat Med. 2000 Jul;6(7):723-4. Unique Identifier : AIDSLINE MED/20348001
- Birmingham K
- Beanie Baby profits support AIDS foundation [news]
- Nat Med. 2000 Jul;6(7):726. Unique Identifier : AIDSLINE MED/20348007
- WHO under attack on HIV drug policy [news]
- Nat Med. 2000 Jul;6(7):726. Unique Identifier : AIDSLINE MED/20348009
- Watanabe ME
- Taking aim at HIV replication [news; comment]
- Nat Med. 2000 Jul;6(7):735-6. Unique Identifier : AIDSLINE MED/20348013
- Finzi D; Siliciano RF
- HIV-1 rebound after anti-retroviral therapy [news; comment]
- Nat Med. 2000 Jul;6(7):736-7. Unique Identifier : AIDSLINE MED/20348014
- Ho DD; Zhang L
- Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy [see comments]
- Nat Med. 2000 Jul;6(7):757-61. Unique Identifier : AIDSLINE MED/20348025
- Chun TW; Davey RT Jr; Ostrowski M; Shawn Justement J; Engel D; Mullins JI; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA. twchun@nih.gov
- We examined the pathogenic significance of the latent viral reservoir in the resting CD4+ T cell compartment of HIV-1-infected individuals as well as its involvement in the rebound of plasma viremia after discontinuation of highly active anti-retroviral therapy (HAART). Using heteroduplex mobility and tracking assays,
- Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo [see comments]
- Nat Med. 2000 Jul;6(7):762-8. Unique Identifier : AIDSLINE MED/20348026
- Chapuis AG; Paolo Rizzardi G; D'Agostino C; Attinger A; Knabenhans C; Fleury S; Acha-Orbea H; Pantaleo G; Laboratory of AIDS Immunopathogenesis, Department of Medicine,; Division of Infectious Diseases, Centre Hospitalier Universitaire; Vaudois, University of Lausanne, 1011 Lausanne, Switzerland.
- Mycophenolic acid, a selective inhibitor of the de novo synthesis of guanosine nucleotides in T and B lymphocytes, has been proposed to inhibit human immunodeficiency virus (HIV) replication in vitro by depleting the substrate (guanosine nucleotides) for reverse transcriptase. Here we show that mycophenolic acid induc
- Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection.
- Nat Med. 2000 Jul;6(7):769-75. Unique Identifier : AIDSLINE MED/20348027
- Mack M; Kleinschmidt A; Bruhl H; Klier C; Nelson PJ; Cihak J; Plachy J; Stangassinger M; Erfle V; Schlondorff D; Medical Policlinic, Ludwig-Maximilians-University,; Pettenkoferstrasse 8a, 80336 Munich, Germany.
- The release of microparticles from eukaryotic cells is a well-recognized phenomenon. We demonstrate here that the chemokine receptor CCR5, the principal co-receptor for macrophage-tropic human immunodeficiency virus (HIV)-1, can be released through microparticles from the surface of CCR5+ Chinese hamster ovary cells a
- Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression.
- Nat Med. 2000 Jul;6(7):782-9. Unique Identifier : AIDSLINE MED/20348029
- Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L; Department of Laboratory of Medicine and Pathobiology, Multi; Organ Transplantation Program, Toronto General Hospital Research; Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada.; lzhang@transplantunit.org
- Despite increasing evidence for the existence of antigen-specific regulatory T cells, the mechanisms underlying suppression remain unclear. In this study we have identified and cloned a novel subset of antigen-specific regulatory T cells and demonstrated that these T cells possess a unique combination of cell surface
- [Complex regional pain syndrome: the need for multidisciplinary approach]
- Rev Neurol. 2000 Mar 16-31;30(6):555-61. Unique Identifier : AIDSLINE MED/20322068
- de la Calle-Reviriego JL; Unidad para el Estudio y Tratamiento del Dolor, Hospital Ramon y; Cajal, Madrid, Espana.
- INTRODUCTION AND DEVELOPMENT: The title complex regional pain syndrome is being introduced to cover the painful syndromes which formerly were described under the headings reflex sympathetic dystrophy and causalgia. The pain may be sympathetically maintained or sympathetically independent. The incidence of disease with
- AIDS and lipodystrophy: complications of HIV and HIV treatments [editorial]
- AIDS Patient Care STDS. 1999 Jul;13(7):389-90. Unique Identifier : AIDSLINE MED/20328677
- Laurence J
- Short-term human growth hormone therapy for HIV-associated wasting [letter]
- AIDS Patient Care STDS. 1999 Jul;13(7):391-3. Unique Identifier : AIDSLINE MED/20328678
- Nemechek PM
- Altered body shape in HIV disease: a side effect of therapy?
- AIDS Patient Care STDS. 1999 Jul;13(7):395-402. Unique Identifier : AIDSLINE MED/20328679
- Baker R; Kotler D; Carr A; Torres RA; Department of Medicine, St. Luke's-Roosevelt Hospital, New York,; New York, USA. ronbaker@pacbell.net
- An interactive teleconference on HIV-associated lipodystrophies and altered body habitus was held on January 20, 1999, part of a series known as HIV Treatment LIVE!. It was moderated by Ronald Baker, Ph.D., and sponsored by the AIDS Wasting Foundation (AWF). AWF, located at 15 East 26th Street, New York, NY 10010, was
- Willingness to treat HIV-positive patients at different stages of medical education and experience.
- AIDS Patient Care STDS. 1999 Jul;13(7):403-14. Unique Identifier : AIDSLINE MED/20328680
- Radecki S; Shapiro J; Thrupp LD; Gandhi SM; Sangha SS; Miller RB; Pacific AIDS Education and Training Center, University of; Southern California School of Medicine, Los Angeles, USA.; sradecki@hsc.usc.edu
- The willingness of physicians to provide care to HIV-positive patients has been linked to a number of attitudinal factors, but little is known concerning the impact of premedical, medical, and residency training on these factors. The purpose of this study is to elicit responses to the same series of questions concerni
- Pathogenesis of non-AIDS-defining cancers: a review.
- AIDS Patient Care STDS. 1999 Jul;13(7):415-26. Unique Identifier : AIDSLINE MED/20328681
- Wistuba II; Behrens C; Gazdar AF; Hamon Center for Therapeutic Oncology Research, University of; Texas Southwestern Medical Center, Dallas, USA.
- As the AIDS epidemic advances, the number of HIV-infected subjects developing AIDS-related neoplasms is rapidly increasing, and the spectrum of malignancies encountered is expanding. Several non-AIDS-defining cancers are being reported at an increasing incidence in HIV-infected individuals, including anal, skin, oral
- Perception of quality of life of persons with HIV/AIDS and maintenance of nutritional parameters while on protease inhibitors.
- AIDS Patient Care STDS. 1999 Jul;13(7):427-33. Unique Identifier : AIDSLINE MED/20328682
- Echeverria PS; Jonnalagadda SS; Hopkins BL; Rosenbloom CA; Department of Nutrition, Georgia State University, Atlanta, USA.
- This descriptive study investigated quality of life issues, biochemical indices, and nutritional parameters of individuals with HIV/AIDS before the initiation of protease inhibitors (PI) and after PI therapy. Telephone interviews were conducted with 45 men and women
- HIV/AIDS case histories: diagnostic problems. So-called "bone marrow pattern of AIDS".
- AIDS Patient Care STDS. 1999 Jul;13(7):435-6. Unique Identifier : AIDSLINE MED/20328683
- Godwin JH; New York Presbyterian Hospital-Weill Medical College, New York,; USA.
- Soft-gel Norvir [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):437. Unique Identifier : AIDSLINE MED/20328684
- Viagra reacts with ritonavir [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):437. Unique Identifier : AIDSLINE MED/20328685
- Amprenavir approved [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):438. Unique Identifier : AIDSLINE MED/20328687
- Monoclonal antibody has efficacy against HIV [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):438. Unique Identifier : AIDSLINE MED/20328686
- 48-week data released for combination treatment with efavirenz [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):438-40. Unique Identifier : AIDSLINE MED/20328688
- Substances may help women [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):442. Unique Identifier : AIDSLINE MED/20328694
- Patient education CD-ROM available [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):442-3. Unique Identifier : AIDSLINE MED/20328696
- Local production of condoms encouraged [news]
- AIDS Patient Care STDS. 1999 Jul;13(7):443-4. Unique Identifier : AIDSLINE MED/20328697
- HIV and STD prevention update: perception of risk varies dramatically.
- AIDS Patient Care STDS. 1999 Jul;13(7):445-7. Unique Identifier : AIDSLINE MED/20328698
- Makulowich GS
- Studies on the pathology, especially brain hemorrhage and angioendotheliomas, induced by two new mos-containing viruses.
- J Neurovirol. 2000 Apr;6(2):106-20. Unique Identifier : AIDSLINE MED/20284032
- Lim KY; Ryan EA; Wong PK; Yuen PH; Department of Carcinogenesis, Science Park-Research Division, The; University of Texas M.D. Anderson Cancer Center, Smithville,; Texas, TX 78957, USA.
- Recombinant virus 7 (R7), a spontaneous deletion mutant of SV7, which is itself a molecular clone of Moloney murine sarcoma virus 124 (MoMuSV 124), induces brain lesions and tumors of the subcutaneous tissue and spleen in all infected mice. In contrast, SV7 only induces tumors of the spleen and subcutaneous tissues. O
- Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis.
- J Neurovirol. 2000 Apr;6(2):121-6. Unique Identifier : AIDSLINE MED/20284033
- Hara T; Yamashita S; Aiba H; Nihei K; Koide N; Good RA; Takeshita K; Department of Pediatrics, Graduate School of Medical Sciences,; Kyushu University, Fukyoka, Fukuoka, Japan.
- Live measles virus-specific T helper 1/T helper 2-cytokine productions by peripheral blood mononuclear cells in response to live measles, mumps or varicella virus were measured in 15 patients with subacute sclerosing panencephalitis and 15 controls by enzyme-linked immunosorbent assays. Most patients with subacute scl
- Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues.
- J Neurovirol. 2000 Apr;6(2):145-55. Unique Identifier : AIDSLINE MED/20284036
- Hudson L; Liu J; Nath A; Jones M; Raghavan R; Narayan O; Male D; Everall I; Department of Neuropathology, Institute of Psychiatry,; DeCrespigny Park, London SE5 8AF, UK.
- Neuropathologically, human immunodeficiency virus (HIV) is associated with a range of inflammatory disorders, extensive cortical neuronal loss, and dendritic and synaptic damage. Although the mechanisms resulting in these abnormalities are still unclear, the neurotoxic effects are thought to be due in part to viral pr
- Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases.
- EBROSPINAL FLUID/ENZYMOLOGY Tuberculosis, Meningeal/CEREBROSPINAL FLUID/ENZYMOLOGY J Neurovirol. 2000 Apr;6(2):156-63. Unique Identifier : AIDSLINE MED/20284037
- Liuzzi GM; Mastroianni CM; Santacroce MP; Fanelli M; D'Agostino C; Vullo V; Riccio P; Department of Biochemistry and Molecular Biology, University of; Bari, 70126 Bari, Italy.
- PCR detection of host and HIV-1 sequences from archival brain tissue.
- J Neurovirol. 2000 Apr;6(2):164-71. Unique Identifier : AIDSLINE MED/20284038
- Smith KM; Crandall KA; Kneissl ML; Navia BA; Program in Genetics, Tufts University, Sackler School of; Biological and Biomedical Sciences, 136 Harrison Avenue, Boston,; Massachusetts, MA 02111, USA.
- Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associat
- Risk and management of blood-borne infections in health care workers.
- Clin Microbiol Rev. 2000 Jul;13(3):385-407. Unique Identifier : AIDSLINE MED/20344705
- Beltrami EM; Williams IT; Shapiro CN; Chamberland ME; HIV Infections Branch, Hospital Infections Program, National; Center for Infectious Diseases, Centers for Disease Control and; Prevention, Public Health Service, U.S. Department of Health and; Human Services, Atlanta, Georgia 30333, USA. ebj4@cdc.gov
- Exposure to blood-borne pathogens poses a serious risk to health care workers (HCWs). We review the risk and management of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in HCWs and also discuss current methods for preventing exposures and recommendations for postex
- Epidemiological features of drug resistant tuberculosis in Harare, 1994 to 1996.
- Cent Afr J Med. 1999 Nov;45(11):282-7. Unique Identifier : AIDSLINE MED/20350373
- Makombe RR; Easterbrook PJ; Lowe O; Ferguson AD; Neill P; Ndudzo A; van der Have JJ; Mbengeranwa OL; Beatrice Road Infectious Diseases Hospital, City Health; Department, Harare, Zimbabwe.
- OBJECTIVES: To characterise the prevalence, clinical and radiological features of drug resistant tuberculosis in selected patients with pulmonary tuberculosis in Harare between 1994 and 1996. DESIGN: A retrospective review of medical and microbiological records. SETTING: Beatrice Road Infectious Diseases Hospital, Har
- Serum immunoglobulin levels in paediatric patients with pneumonia.
- Cent Afr J Med. 1999 Nov;45(11):300-2. Unique Identifier : AIDSLINE MED/20350377
- Mazengera LR; Nathoo KJ; Zegers BJ; Department of Immunology, University of Zimbabwe Medical School,; Avondale, Harare, Zimbabwe.
- OBJECTIVE: To determine levels of serum immunoglobulins IgG, IgM and IgA in patients admitted with pneumonia to Harare Central Hospital paediatric wards. DESIGN: A cross sectional pilot study. SETTING: Harare Central Hospital, Department of Immunology, University of Zimbabwe ; Dep
- Alcohol consumption in HIV-I infected persons: a study of immunological markers, Harare, Zimbabwe.
- Cent Afr J Med. 1999 Nov;45(11):303-8. Unique Identifier : AIDSLINE MED/20350378
- Chandiwana SK; Sebit MB; Latif AS; Gomo E; Acuda SW; Makoni F; Vushe J; Blair Research Institute, Harare.
- OBJECTIVE: To examine the effect of alcohol use in relation to the age, gender and plasma levels of HIV-I RNA and CD4 cells count in HIV-I infected persons as a prognostic indicator for the disease progression to AIDS. DESIGN: A community based cohort study. SETTING: The study was conducted at the Blair Research Insti
- CD8(+) T cells secreting type 2 lymphokines are defective in protection against viral infection.
- Cell Immunol. 2000 May 25;202(1):13-22. Unique Identifier : AIDSLINE MED/20334541
- Wirth S; van den Broek M; Frossard CP; Hugin AW; Leblond I; Pircher H; Hauser C; Allergy Unit, Division of Immunology and Allergy, Hopital; Cantonal Universitaire, Geneva, Switzerland.
- Effector T cells secreting type 1 and/or type 2 lymphokines (Tc1, Tc0, Tc2) were generated in vitro from CD8(+) T cells of mice with a transgenic TCR recognizing lymphocytic choriomeningitis virus (LCMV) glycoprotein to compare their effector function in vitro and in vivo. Tc1, Tc2, and Tc0 showed similar Fas- and per
- Preferential proliferation and differentiation of double-positive thymocytes into CD8(+) single-positive thymocytes in a novel cell culture medium.
- Cell Immunol. 2000 May 25;202(1):41-53. Unique Identifier : AIDSLINE MED/20334544
- Gao JX; Zhang J; Awaraji C; Bhatia M; Jevnikar A; Singh B; Bell D; Delovitch TL; Autoimmunity/Diabetes Group, The University of Western Ontario,; London, Ontario, N6G 2V4, Canada.
- The identification of factors that regulate the proliferation and differentiation of double-positive (DP) into CD4(+) and CD8(+) single-positive (SP) thymocytes has proven difficult due to the inability of DP thymocytes to proliferate, expand, and differentiate into SP thymocytes in available cell culture media. Here
- Role of T cell subsets in the modulation of Mycobacterium avium growth within human monocytes.
- Cell Immunol. 2000 May 25;202(1):6-12. Unique Identifier : AIDSLINE MED/20334540
- Shiratsuchi H; Krukovets I; Ellner JJ; Case Western Reserve University, Cleveland, Ohio, 44106-4984,; USA.
- Mycobacterium avium frequently causes disseminated disease in patients with advanced AIDS with low CD4 counts. The effects of T lymphocyte on intracellular M. avium replication were examined. Plastic adherent monocytes and nonadherent lymphocytes were separated from peripheral blood mononuclear cells. After infection
- gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice.
- Cell Immunol. 2000 May 25;202(1):61-9. Unique Identifier : AIDSLINE MED/20334546
- Naiki Y; Nishimura H; Itohara S; Yoshikai Y; Laboratory of Host Defense and Germ-free Life, Nagoya University; School of Medicine, Nagoya, 466-0053, Japan.
- To investigate the roles of gammadelta T cells in Salmonella infection, we examined the resolution of an intraperitoneal infection with avirulent Salmonella choleraesuis 31N-1 in mice lacking T-cell-receptor (TCR) alphabeta T cells by disruption of the TCRbeta chain gene (TCRbeta(-/-)). The bacteria in TCRbeta(-/-) mi
- Antiretroviral combination therapy in HIV-1 infected women and men: are their responses different?
- Int J Fertil Womens Med. 2000 Mar-Apr;45(2):195-9. Unique Identifier : AIDSLINE MED/20290036
- Zorrilla CD; Department of Obstetrics and Gynecology, University of Puerto; Rico, School of Medicine, San Juan 00936-5067, USA.
- Women are the fastest growing segment of the AIDS cases in the United States . They constitute nearly half of all the AIDS cases worldwide. Recent advances in Highly Active Antiretroviral Therapies (HAART) have reduced AIDS mortality remarkably. But as longer use of these combination re
- C-sections recommended for HIV+ pregnant women.
- AWHONN Lifelines. 1999 Oct-Nov;3(5):17. Unique Identifier : AIDSLINE MED/20286914
- Pain management in HIV-positive patients.
- Adv Nurse Pract. 1999 Nov;7(11):49-51. Unique Identifier : AIDSLINE MED/20346006
- Epley D; Florida State University School of Nursing, Tallahassee, USA.
- Mouse mammary tumor virus-like ENV gene sequences in human breast tumors and in a lymphoma of a breast cancer patient.
- Clin Cancer Res. 2000 Apr;6(4):1273-8. Unique Identifier : AIDSLINE MED/20239222
- Etkind P; Du J; Khan A; Pillitteri J; Wiernik PH; Our Lady of Mercy Medical Center-Comprehensive Cancer Center, New; York Medical College, Bronx 10466-4002, USA.
- DNA sequences with very high similarity (95-98%) to the mouse mammary tumor virus (MMTV) ENV gene have been amplified by PCR in 38.5% of human breast tumors and in
- Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma.
- Clin Cancer Res. 2000 Apr;6(4):1351-64. Unique Identifier : AIDSLINE MED/20239234
- Saito T; Dworacki G; Gooding W; Lotze MT; Whiteside TL; University of Pittsburgh Cancer Institute, University of; Pittsburgh School of Medicine, Pennsylvania 15213, USA.
- Peripheral blood mononuclear cells (PBMCs) obtained from patients with advanced melanoma but not from healthy individuals were found to undergo spontaneous ex vivo apoptosis upon incubation in medium. PBMCs were evaluated for evidence of apoptosis using Annexin V binding, caspase-3 activation, and DNA fragmentation (t
- A new vector-search rotation function: image-seeking functions revisited in macromolecular crystallography.
- Acta Crystallogr D Biol Crystallogr. 2000 Jun;56 ( Pt 6):735-46. Unique Identifier : AIDSLINE MED/20280188
- Borge J; Alvarez-Rua C; Garcia-Granda S; Departamento de Quimica Fisica y Analitica, Facultad de; Quimica, Universidad de Oviedo, Spain.; jjba@sauron.quimica.uniovi.es
- A new rotation function in Patterson space is described. An image-seeking function can be defined as a criterion of fit between the observed Patterson map and a suitable vector set extracted from a specially calculated Patterson map of the search model. The behaviour of image-seeking functions has appeared to be heavi
- Unique morphological alterations of the HTLV-I transformed C8166 cells by infection with HIV-1.
- Pathol Oncol Res. 2000;6(1):27-37. Unique Identifier : AIDSLINE MED/20213656
- Ongradi J; Laird HM; Szilagyi JF; Horvath A; Bendinelli M; National Institute of Dermato-Venerology Maria utca 41.,; Budapest, 1085, Hungary. ongjos@hotmail.com
- C8166 cells express T lymphocyte markers, a monocyte-specific esterase, taxpolypeptide of HTLV-I. In spite of this transactivator, their HIV-1 yield is low. Their culture conditions were modified, and infected cells were immobilized on a poly-L-lysine sheet under semisolid overlays to study their phenotypic alteration
- International conference spotlights disaster in sub-Saharan Africa [news]
- Circulation. 2000 Jul 18;102(3):E9005-6. Unique Identifier : AIDSLINE MED/20359943
- SoRelle R
- NMR structure of an anti-gp120 antibody complex with a V3 peptide reveals a surface important for co-receptor binding.
- Structure Fold Des. 2000 Apr 15;8(4):385-95. Unique Identifier : AIDSLINE PDB/1NQZ
- Tugarinov V; Zvi A; Levy R; Hayek Y; Matsushita S; Anglister J; Department of Structural Biology, The Weizmann Institute of; Science, Rehovot, 76100, Israel.
- BACKGROUND: The protein 0.5beta is a potent strain-specific human immunodeficiency virus type 1 (HIV-1) neutralizing antibody raised against the entire envelope glycoprotein (gp120) of the HIV-1(IIIB) strain. The epitope recognized by 0.5beta is located within the third hypervariable region (V3) of gp120. Recently, se
- New developments in the treatment of HIV disease: an overview.
- J Child Fam Nurs. 1999 Nov-Dec;2(6):439-41. Unique Identifier : AIDSLINE MED/20306393
- Kiernan BS
- Most env and gag subtype A HIV-1 viruses circulating in West and West Central Africa are similar to the prototype AG recombinant virus IBNG.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):363-74. Unique Identifier : AIDSLINE +
- Montavon C; Toure-Kane C; Liegeois F; Mpoudi E; Bourgeois A; Vergne L; Perret JL; Boumah A; Saman E; Mboup S; Delaporte E; Peeters M; Laboratoire Retrovirus, Institut pour la Recherche en; Developement, Montpellier, France.
- The genetic subtype was identified in gag and env of 219 HIV-1-positive samples collected in different African countries, 44 from Senegal , 55 from Cameroon , 82 from Gabon , and 38 from
- Fluctuations in HIV-1 viral load are correlated to CD4+ T-lymphocyte count during the natural course of infection.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):375-9. Unique Identifier : AIDSLINE MED/20322598
- Masel J; Arnaout RA; O'Brien TR; Goedert JJ; Lloyd AL; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Department of Zoology, University of Oxford, UK.
- Viral load fluctuates during the natural course of asymptomatic HIV-1 infection. It is often assumed that these fluctuations are random around a set point or underlying growth trend. Using longitudinal data, we tested whether fluctuations in viral load can be better explained by changes in CD4+ T-cell count than by a
- HAART is neuroprophylactic in HIV-1 infection.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):380-5. Unique Identifier : AIDSLINE MED/20322599
- von Giesen HJ; Hefter H; Jablonowski H; Arendt G; Department of Neurology, Heinrich Heine University, Dusseldorf,; Germany. giesenhj@uni-duesseldorf.de
- BACKGROUND: To find out about the prophylactic value of antiretroviral therapy on HIV-1-associated subclinical and clinical psychomotor slowing as one marker of HIV-1-associated CNS disease. METHODS: Prospective study with regular clinical and neurophysiologic examination every three months of 1482 consecutive HIV-1-s
- Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):386-95. Unique Identifier : AIDSLINE MED/20322600
- Gifford AL; Bormann JE; Shively MJ; Wright BC; Richman DD; Bozzette SA; Health Services Research and Development, VA San Diego Healthcare; System, California 92161, USA. agifford@ucsd.edu
- BACKGROUND: Adherence to prescribed medications is a central feature of good clinical HIV care, but little is known about the factors associated with multidrug antiretroviral adherence, or about how such adherence is related to plasma HIV suppression. METHODS: We collected data from 133 HIV-infected adults receiving a
- Impact of medical and nonmedical factors on physician decision making for HIV/AIDS antiretroviral treatment.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):396-404. Unique Identifier : AIDSLINE MED/20322601
- Bogart LM; Kelly JA; Catz SL; Sosman JM; Department of Psychology, Kent State University, Ohio 44242-0001,; USA. lbogart@kent.edu
- To examine influences of medical factors (e.g., viral load) and nonmedical factors (e.g., patient characteristics) on treatment decisions for highly active antiretroviral therapy (HAART), we sent a survey to a random sample of 995 infectious disease physicians who treat patients with HIV/AIDS in the
- High HIV incidence and prevalence among young women in rural South Africa: developing a cohort for intervention trials.
- Unique Identifier : AIDSLINE MED/20322602
- Wilkinson D; Abdool Karim SS; Williams B; Gouws E
- OBJECTIVE: To measure prevalence and model incidence of HIV infection. SETTING: 2013 consecutive pregnant women attending public sector antenatal clinics in 1997 in Hlabisa health district, South Africa . Historical seroprevalence data, 1992-1995. METHODS: Serum remaining from syph
- Monitoring of HIV-1 infection prevalence and trends in the general population using pregnant women as a sentinel population: 9 years experience from the Kagera region of Tanzania.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):410-7. Unique Identifier : AIDSLINE MED/20322603
- Kwesigabo G; Killewo JZ; Urassa W; Mbena E; Mhalu F; Lugalla JL; Godoy C; Biberfeld G; Emmelin M; Wall S; Sandstrom A; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; gkwesigabo@muchs.ac.tz
- In the Kagera region of Tanzania , a population-based study was initiated in 1987 followed by the establishment of antenatal-clinic-based sentinel surveillance system in the town of Bukoba in 1990. Repeat studies in both populations in Bukoba in 1993 and 1996 made it possible to s
- Case-control study of risk factors for incident HIV infection in rural Uganda.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):418-25. Unique Identifier : AIDSLINE MED/20322604
- Quigley MA; Morgan D; Malamba SS; Mayanja B; Okongo MJ; Carpenter LM; Whitworth JA; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
- OBJECTIVE: To identify risk factors associated with HIV incidence in a rural Ugandan population. DESIGN: Case-control study. METHODS: Men and women who seroconverted between 1990 and 1997 (cases) and seronegative subjects (controls) were drawn from a general population cohort of approximately 5000 adults in rural, sou
- Low estimates of HIV seroconversions among clients of a drug treatment clinic in San Francisco, 1995 to 1998.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):426-9. Unique Identifier : AIDSLINE MED/20322605
- McFarland W; Kellogg TA; Louie B; Murrill C; Katz MH; Department of Public Health, San Francisco, California; 94102-6033, USA. WilliMcFarland@dph.sf.ca.us
- We estimated HIV incidence among injection drug users attending a drug treatment clinic in San Francisco from 1995 to 1998 using two methods. An anonymous sequential testing method identified no seroconversions among clients seen more than once during the period (one-sided upper 95% confidence limit 1.02 per 100 perso
- Distribution of HIV-1 subtypes among HIV-seropositive patients in the interior of Cote d'Ivoire.
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):430-6. Unique Identifier : AIDSLINE GENBANK/AF216889
- Nkengasong JN; Luo CC; Abouya L; Pieniazek D; Maurice C; Sassan-Morokro M; Ellenberger D; Hu DJ; Pau CP; Dobbs T; Respess R; Coulibaly D; Coulibaly IM; Wiktor SZ; Greenberg AE; Rayfield M; Laboratory of Virology, Project RETRO-CI, Abidjan, Cote; d'Ivoire. jcn5@cdc.gov
- Limited data exist on the distribution of HIV-1 subtypes in Cote d Ivoire . The aim of this study is to describe the distribution of genetic subtypes of HIV-1 strains in six regions of Cote d Ivoire. In 1997, we consecutively collected blood from 172 HIV-1-infected patients fro
- Multigenic polymorphisms of HIV-1 coreceptors and vertical transmission [letter; comment]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):437. Unique Identifier : AIDSLINE MED/20322607
- Araujo F; Miranda M; Koch C; Marques R; Cunha-Ribeiro LM
- Routine ophthalmologic screening for cytomegalovirus retinitis in patients with AIDS [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):438-9. Unique Identifier : AIDSLINE MED/20322608
- Wohl DA; Pedersen S; van der Horst CM
- Effects of 2-year antiretroviral combination therapies on HIV-1 DNA levels [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):439-41. Unique Identifier : AIDSLINE MED/20322609
- Zanussi S; Bortolin MT; Tirelli U; Nasti G; Vaccher E; Giacca M; De Paoli P
- No evidence of HTLV-I or HTLV-II infection among the Hmong people of northern Thailand or injecting drug users in Bangkok [letter]
- J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):441-2. Unique Identifier : AIDSLINE MED/20322610
- Louisiriotchanakul S; Thongput A; Khamboonruang C; Taylor GP; Kunstadter P; Wasi C
- Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):1-9. Unique Identifier : AIDSLINE MED/20334000
- Tscherning-Casper C; Vodros D; Menu E; Aperia K; Fredriksson R; Dolcini G; Chaouat G; Barre-Sinoussi F; Albert J; Fenyo EM; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden. charlotte.tscherning@mtc.ki.se
- In this study, coreceptor usage of HIV-1 other than subtype B in relation to HIV-1 transmission from mother to child was investigated. Repeated sampling of 42 HIV-1-seropositive, asymptomatic women in Cameroon during the second and third trimesters of pregnancy, at delivery, and
- A novel role for tumor necrosis factor-alpha in regulating susceptibility of activated CD4+ T cells from human and nonhuman primates for distinct coreceptor using lentiviruses.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):10-22. Unique Identifier : AIDSLINE MED/20334001
- Brice GT; Mayne AE; Villinger F; Ansari AA; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, Georgia 30322, USA.
- Although CD4+ T-cell activation has long been shown to promote infection and replication of simian immunodeficiency virus (SIV) and HIV, recent studies have documented that not all activated CD4+ T cells from human and nonhuman primates are susceptible to infection with HIV/SIV, respectively. Activation of CD4+ T cell
- Autopsy study of HIV-1-positive and HIV-1-negative adult medical patients in Nairobi, Kenya.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):23-9. Unique Identifier : AIDSLINE MED/20334002
- Rana FS; Hawken MP; Mwachari C; Bhatt SM; Abdullah F; Ng'ang'a LW; Power C; Githui WA; Porter JD; Lucas SB; Department of Pathology, University of Nairobi and Kenyatta; National Hospital, Nairobi, Kenya.
- HIV infection has now been consistently identified as the major cause of death in young Africans in both urban and rural areas. In Africa, several studies have defined the clinical presentation of HIV disease but there have only been a limited number of autopsy studies. Because of the scarcity of autopsy data and the
- Clinical prediction model for differentiation of disseminated Histoplasma capsulatum and Mycobacterium avium complex infections in febrile patients with AIDS.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):30-6. Unique Identifier : AIDSLINE MED/20334003
- Graviss EA; Vanden Heuvel EA; Lacke CE; Spindel SA; White AC Jr; Hamill RJ; Section of Infectious Diseases, Veterans Affairs Medical Center,; Houston, Texas 77030-4211, USA.
- BACKGROUND: Disseminated infection with Histoplasma capsulatum and Mycobacterium avium complex (MAC) in patients with AIDS are frequently difficult to distinguish clinically. METHODS: We retrospectively compared demographic information, other opportunistic infections, medications, symptoms, physical examination findin
- Randomized controlled trial assessing the effect of vitamin A supplementation on maternal morbidity during pregnancy and postpartum among HIV-infected women.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):37-44. Unique Identifier : AIDSLINE MED/20334004
- Kennedy CM; Coutsoudis A; Kuhn L; Pillay K; Mburu A; Stein Z; Coovadia H; Joseph L. Mailman School of Public Health, Columbia University,; New York City, New York 10032, USA.
- OBJECTIVE: To determine whether low-cost treatment of HIV using vitamin A would be beneficial, we examined the effect of vitamin A supplementation on morbidity of HIV-1 infected women. METHODS: We conducted a randomized, double blind placebo-controlled trial at King Edward VIII Hospital, in Durban,
- Trends in antiretroviral therapy and mother-infant transmission of HIV. The Women and Infants Transmission Study Group.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):45-7. Unique Identifier : AIDSLINE MED/20334005
- Cooper ER; Charurat M; Burns DN; Blattner W; Hoff R; Boston Medical Center, Department of Pediatrics, Boston; University School of Medicine, Massachusetts, USA.
- Trends in the vertical transmission rate of HIV and evolving antiretroviral usage between 1990 and 1998 within the Women and Infants Transmission Study were evaluated. A decline in mother-infant transmission was temporally associated with advances in therapy, especially when regimens including a protease inhibitor wer
- Sexually transmitted diseases and the increased risk for HIV transmission: implications for cost-effectiveness analyses of sexually transmitted disease prevention interventions.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):48-56. Unique Identifier : AIDSLINE MED/20334006
- Chesson HW; Pinkerton SD; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.
- We estimated the annual number and cost of new HIV infections in the United States attributable to other sexually transmitted diseases (STDs). We used a mathematical model of HIV transmission to estimate the probability that a given STD infection would facilitate HIV transmission from
- Comparing new participants of a mobile versus a pharmacy-based needle exchange program.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):57-61. Unique Identifier : AIDSLINE MED/20334007
- Riley ED; Safaeian M; Strathdee SA; Marx MA; Huettner S; Beilenson P; Vlahov D; Department of Epidemiology, The Johns Hopkins School of Hygiene; and Public Health, Baltimore, Maryland, USA.
- OBJECTIVE: To compare characteristics of first-time needle exchange participants who enrolled at a mobile van-based exchange site versus a fixed pharmacy-based exchange site, in an area where both types of needle exchange programs were available. METHODS: Demographic and drug use data were collected on needle exchange
- Effect of intravaginal practices on the vaginal and cervical mucosa of Zimbabwean women.
- Unique Identifier : AIDSLINE MED/20334008
- van de Wijgert JH; Chirenje ZM; Iliff V; Mbizvo MT; Mason PR; Gwanzura L; Shiboski S; Padian NS
- OBJECTIVES: Lesions on the vaginal and cervical mucosa may facilitate transmission of HIV and other sexually transmitted diseases (STDs). We evaluated the relationship between intravaginal practices and the presence of colposcopic lesions in Zimbabwean women. METHODS: Users and nonusers of intravaginal practices were
- Effect of HIV infection on menstrual cycle length.
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):68-75. Unique Identifier : AIDSLINE MED/20334009
- Harlow SD; Schuman P; Cohen M; Ohmit SE; Cu-Uvin S; Lin X; Anastos K; Burns D; Greenblatt R; Minkoff H; Muderspach L; Rompalo A; Warren D; Young MA; Klein RS; University of Michigan, Ann Arbor, USA.
- HIV serostatus and menstrual function were examined using prospectively collected menstrual data from 802 HIV-seropositive and 273 HIV-seronegative women, ages 20 to 44, enrolled in two cohort studies of HIV infection in North American women. The associations between HIV serostatus and the probabilities of having a cy
- Can early failure with nevirapine be rescued with efavirenz? [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):76-8. Unique Identifier : AIDSLINE MED/20334010
- Briones C; Soriano V; Dona C; Barreiro P; Gonzalez-Lahoz J
- Reversal of hyperlipidemia and lipodystrophy in patients switching therapy to nelfinavir [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):78-9. Unique Identifier : AIDSLINE MED/20334011
- Duncombe C
- Eradication of Helicobacter pylori is associated with increased exposure to delavirdine in hypochlorhydric HIV-positive patients [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):79-82. Unique Identifier : AIDSLINE MED/20334012
- Shelton MJ; Akbari B; Hewitt RG; Adams JM; Morse GD
- Definition of virologic response and the type of assay used for quantification of viral load may influence the proportion of responders to antiretroviral therapy. APROCO Study Group [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):82-3. Unique Identifier : AIDSLINE MED/20334013
- Le Moing V; Chene G; Masquelier B; Sicard D; Brun-Vezinet F; Reynes J; Raffi F
- High, low, and very low viral loads of HIV in the United States [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):83-4. Unique Identifier : AIDSLINE MED/20334014
- Peter JB
- Antiretroviral combination therapies and AIDS-defining cancers [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):84-6. Unique Identifier : AIDSLINE MED/20334015
- Serraino D; Pezzotti P; Boros S; Rezza G
- Lack of evidence for a role of HTLV-I infection in the occurrence of subclinical HAM/TSP in the Miyazaki Cohort Study [letter]
- J Acquir Immune Defic Syndr. 2000 May 1;24(1):86-7. Unique Identifier : AIDSLINE MED/20334016
- Abtahi A; Mueller N; Okayama A; Stuver S
- Seroprevalence of parvovirus B19 among HIV-1-positives in Japan.
- Jpn J Infect Dis. 2000 Feb;53(1):21. Unique Identifier : AIDSLINE MED/20242107
- Taguchi H; Yamada T; Takahashi T; Gotoh M; Nakamura T; Iwamoto A; Department of Infectious Diseases, Institute of Medical Science,; University of Tokyo, Tokyo 108-8639, Japan.
- The "beta-fluorine effect" in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates.
- Unique Identifier : AIDSLINE MED/20232684
- Siddiqui MA
- Conformation and local environment of nucleotides bound to HIV type 1 reverse transcriptase (HIV-1 RT) in the ground state.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):13-29. Unique Identifier : AIDSLINE MED/20232685
- Painter GR; Andrews CW; Furman PA; Triangle Pharmaceuticals, Inc. Durham, NC, USA.
- Nuclear Overhauser effect experiments were used to characterize the protein environment and conformations of dTTP, dATP and AZTTP bound to HIV-RT in the ground state. The results show the initial binding sites for the nucleotides overlap but are not completely coincident. All of the bound nucleotides assume the same a
- Benzimidazole 2'-isonucleosides: design, synthesis, and antiviral activity of 2-substituted-5,6-dichlorobenzimidazole 2'-isonucleosides.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):155-74. Unique Identifier : AIDSLINE MED/20232692
- Freeman GA; Selleseth DW; Rideout JL; Harvey RJ; Division of Medicinal Chemistry, GlaxoWellcome Research, North; Carolina 27709, USA.
- 2,5,6-Trihalogenated benzimidazole-beta-D-ribofuranosyl nucleosides and 2-substituted amino-5,6-dichlorobenzimidazole-beta-L-ribofuranosyl nucleosides are potent and selective inhibitors of human cytomegalovirus (HCMV). The D-ribofuranosyl analogs are metabolized rapidly in vivo re
- Synthesis and antiviral evaluation of unnatural beta-L-enantiomers of 3'-fluoro- and 3'-azido-2',3'-dideoxyguanosine derivatives.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):205-17. Unique Identifier : AIDSLINE MED/20232695
- Marchand A; Mathe C; Imbach JL; Gosselin G; Laboratoire de Chimie Organique Biomoleculaire de Synthese,; U.M.R. CNRS 5625, Universite de Montpellier II, France.
- 3 -fluoro-2 ,3 -dideoxy- (3) and 3 -azido-2 ,3 -dideoxy- (4) beta-L-ribofuranonucleoside derivatives of guanine have been synthesized and their antiviral properties examined. All these derivatives were regioselectively and stereospecifically prepared by glycosylation of 2-N-acetyl-6-O-(diphenylcarbamoyl)guanine 5 with
- Synthesis of L-3'-hydroxymethylribonucleosides.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):219-36. Unique Identifier : AIDSLINE MED/20232696
- Cooperwood JS; Boyd V; Gumina G; Chu CK; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens 30602-2352, USA.
- The target compounds were synthesized via the key intermediate carbohydrate 8, which was synthesized by first selectively protecting the 1 - and 2 -hydroxyl groups followed by selective tosylation of the 5 -hydroxyl group to obtain compound 3. The tosyl moiety was then replaced by a benzyl either to obtain 4. Compound
- Synthesis and antiviral activities of enantiomeric 1-[2-(hydroxymethyl) cyclopropyl] methyl nucleosides.
- Unique Identifier : AIDSLINE MED/20232698
- Pierra C; Olgen S; Cavalcanti SC
- Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):283-95. Unique Identifier : AIDSLINE MED/20232701
- Nishizono N; Nair V; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.
- The aminoglycosidic antibiotic, neomycin B, is an inhibitor of the binding of Rev to RRE. This paper reports on the synthesis of analogs of neomycin B as potential anti-HIV compounds designed to function as inhibitors of Rev/RRE binding.
- An efficient, scalable synthesis of the HIV reverse transcriptase inhibitor Ziagen (1592U89).
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):297-327. Unique Identifier : AIDSLINE MED/20232702
- Daluge SM; Martin MT; Sickles BR; Livingston DA; Division of Medicinal Chemistry, Glaxo Wellcome Inc., Research; Triangle Park, North Carolina 27709, USA.
- Ziagen , (1S,cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]- 2-cyclopentene-1-methanol, was synthesized from (1S,4R)-azabicyclo[2.2.1]hept-5-en-3-one by efficient processes which bypass problematic steps in earlier routes. 2-Amino-4,6-dichloro-5-f
- Synthesis of (Z)- and (E)-9-[(2-hydroxyethylidene)cyclopropyl]adenine--new methylenecyclopropane analogues of adenosine and their substrate activity for adenosine deaminase.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):31-7. Unique Identifier : AIDSLINE MED/20232686
- Qui YL; Ksebati MB; Zemlicka J; Department of Chemistry, Barbara Ann Karmanos Cancer Institute,; Wayne State University School of Medicine, Detroit, MI; 48201-1379, USA.
- Synthesis of Z- and E-methylenecyclopropane analogues of adenosine 3 and 4 by alkylation of adenine with novel alkylating agent 5 is described. The E-isomer 4 is a substrate for adenosine deaminase. Compounds 3 and 4 were tested for antiviral activity against HCMV, HSV-1, HSV-2, EBV, VZV, HBV and HIV-1.
- Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):371-7. Unique Identifier : AIDSLINE MED/20232706
- Gao WY; Johns DG; Mitsuya H; Experimental Retrovirology Section, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-4255,; USA.
- Low levels of the CTP synthase inhibitor 3-deazauridine (3-DU) strongly potentiated the anti-HIV-1 activity of the 5 -triphosphates of the cytidine-based analogues [-]2 -deoxy-3 -thiacytidine ( 3TC ; lamivudine) and 2 ,3 -dideoxycytidine (
- Cellular phosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key intermediate in the activation of the antiviral agent DDI, in human peripheral blood mononuclear cells.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):405-13. Unique Identifier : AIDSLINE MED/20232708
- Robbins BL; Greenhaw J; Fridland A; Department of Infectious Disease, St. Jude Children's Research; Hospital, Memphis, TN 38105, USA. brian.robbins@stjude.org
- 2 ,3 -dideoxyadenosine 5-monophosphate (ddAMP), is a key intermediate in the metabolism of the antiviral agent 2 ,3 -dideoxyinosine (ddI) to its active triphosphate derivative, 2 ,3 -dideoxyadenosine-5 -triphosphate (ddATP). The potential role of adenylate kinase in the phosphorylation of ddAMP was studied in human pe
- Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):415-34. Unique Identifier : AIDSLINE MED/20232709
- Graham KA; Leithoff J; Coe IR; Mowles D; Mackey JR; Young JD; Cass CE; Department of Oncology, University of Alberta, Cross Cancer; Institute, Edmonton, Canada.
- The transportability of cytosine-containing nucleosides by recombinant hCNT1 was investigated in transfected mammalian cells. Apparent K(m) values for hCNT1-mediated transport of uridine, cytidine and deoxycytidine were, respectively, 59, 140 and 150 microM. Uridine transport was inhibited 89, 32 and 11%, respectively
- Synthesis and antiviral activity of amino acid carbamate derivatives of AZT.
- Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):87-100. Unique Identifier : AIDSLINE MED/20232689
- Chang SL; Griesgraber G; Abraham TW; Garg T; Song H; Zimmerman CL; Wagner CR; Department of Medicinal Chemistry, College of Pharmacy,; University of Minnesota, Minneapolis 55455, USA.
- Lipophilic amino acid methyl ester and methyl amide carbamates of 3 -azido-3 -deoxythymidine ( AZT ) were synthesized and their anti-HIV-1 activity in PBMCs was determined. The methyl amides were more potent (EC50s = 1.8-4.0 microM) than the methyl este
- Stress and coping: the psychoneuroimmunology of HIV/AIDS.
- Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):615-33. Unique Identifier : AIDSLINE MED/20361000
- Balbin EG; Ironson GH; Solomon GF; University of Miami, Behavioral Medicine Program, Coral Gables,; FL 33124-2070, USA.
- A considerable body of evidence, reviewed in this chapter, suggests that psychosocial factors play an important role in progression of HIV infection, its morbidity and mortality. Psychosocial influences relating to faster disease progression include life-event stress, sustained depression, denial/avoidance coping, con
- Immunoregulation by aqueous humor.
- Cornea. 2000 May;19(3 Suppl):S24-5. Unique Identifier : AIDSLINE MED/20290315
- Mochizuki M; Sugita S; Ishikawa N; Watanabe T; Department of Visual Science, Tokyo Medical and Dental University; Graduate School, Japan.
- PURPOSE: The eye is a classic example of an immune-privileged site. To investigate the local defense system of the eye, the immunosuppressive effects of the aqueous humor on cytokine production was examined. METHODS: Using T cell clones (TCCs) established from infiltrating cells in the aqueous humor of patients with h
- Transverse leukonychia with systemic infection.
- Cutis. 2000 May;65(5):318-20. Unique Identifier : AIDSLINE MED/20285845
- Mautner GH; Lu I; Ort RJ; Grossman ME; New York-Presbyterian Hospital, Columbia-Presbyterian Center,; Dermatology Consultation Service, New York, USA.
- Transverse white nail bands (leukonychia) have been described in association with systemic illnesses and exposure to toxins, and medications. We describe the occurrence of transverse nail bands in two patients following acute systemic illnesses. In the first case, transverse white nail bands developed in a 30-year-old
- Ulcerated atrophic striae from etretinate.
- Cutis. 2000 May;65(5):327-8. Unique Identifier : AIDSLINE MED/20285847
- Bowman PH; Hogan DJ; Louisiana State University Medical Center, Section of Dermatology; Shreveport 71130-3932, USA.
- Oral retinoids such as etretinate and acitretin are commonly associated with dose-dependent, mucocutaneous side effects such as dryness, peeling, and fragility. Although these effects can be extreme in some patients and even require discontinuation of treatment, thinning of skin to the point of atrophy and ulceration
- Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
- Drug Metab Dispos. 2000 Jun;28(6):655-60. Unique Identifier : AIDSLINE MED/20281460
- Choo EF; Leake B; Wandel C; Imamura H; Wood AJ; Wilkinson GR; Kim RB; Departments of Medicine and Pharmacology, Division of Clinical; Pharmacology, Vanderbilt University School of Medicine,; Nashville, Tennessee, USA.
- HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and testes (sanctuary sites) are possibly protected from exposure to HIV protease inhibitors due to drug entry being limited by the membrane
- First-pass disposition of (-)-6-aminocarbovir in rats: II. Inhibition of intestinal first-pass metabolism.
- Drug Metab Dispos. 2000 Jun;28(6):672-9. Unique Identifier : AIDSLINE MED/20281463
- Zimmerman CL; Wen Y; Remmel RP; Departments of Pharmaceutics and Medicinal Chemistry, University; of Minnesota, College of Pharmacy, Minneapolis, Minnesota, USA.; zimme005@tc.umn.edu
- A CBV [(-)-carbovir, (-)-carbocyclic 2 ,3 -didehydro-2 , 3 -dideoxyguanosine] prodrug, 6AC [(-)-6-aminocarbovir, (-)-carbocyclic 2 ,3 -didehydro-2 , 3 -dideoxy-6-deoxy-6-aminoguanosine], was previously evaluated in rats, and it exhibited superiority to the parent drug in increasing systemic and central nervous system
- [Metabolic complications of antiretroviral therapy of HIV infection]
- Dtsch Med Wochenschr. 2000 Jun 16;125(24):771-3. Unique Identifier : AIDSLINE MED/20360974
- Goebel FD; Walli R; Medizinische Poliklinik, Klinikum Innenstadt, Munchen.
- Dominant expansion of human T cells in non-obese diabetic/severe combined immunodeficiency mice implanted with human bone fragments.
- Exp Hematol. 2000 Jul;28(7):792-801. Unique Identifier : AIDSLINE MED/20362887
- Fujiki Y; Onodera M; Yamaguchi T; Osawa M; Sudo K; Hamada H; Ema H; Shibuya A; Takiguchi M; Kubo T; Nakauchi H; Department of Immunology, Institute of Basic Medical Sciences and; Center for Tsukuba Advanced Research Alliance, University of; Tsukuba and CREST, Japan Science and Technology Corporation,; Ibaraki.
- OBJECTIVE: To establish an in vivo animal model in which human T cells develop and function normally, a step toward developing new vaccines or chemical compounds that modulate immune functions and toward understanding T-cell immunity in humans. MATERIALS AND METHODS: Human bone fragments were implanted into non-obese
- Regulatory role of Th-2 cytokines, IL-10 and IL-4, in cardiac allograft rejection.
- Exp Mol Pathol. 2000 Aug;69(1):1-9. Unique Identifier : AIDSLINE MED/20351361
- Mulligan MS; Warner RL; McDuffie JE; Bolling SF; Sarma JV; Ward PA; Division of Cardiothoracic Surgery, University of Washington; Medical Center, Seattle, Washington, 98195, USA.
- The host response to alloantigen results in T- and B-cell activation, upregulation of Class II MHC antigens, and cytokine production by Th-1 cells, resulting in generation of IL-2 and IFN gamma. Th-2 cell responses produce IL-4 and IL-10 which may shift the immune resp
- Chemokine receptor-related genetic sequences in an african green monkey simian cytomegalovirus-derived stealth virus.
- Exp Mol Pathol. 2000 Aug;69(1):10-6. Unique Identifier : AIDSLINE MED/20351362
- Martin WJ; Center for Complex Infectious Diseases, Rosemead, California,; 91770, USA.
- The US28 gene of human cytomegalovirus (HCMV) codes a cell surface receptor for both beta chemokine and fractalkine molecules. This receptor facilitates HCMV-induced cell fusion and virus dissemination and influences susceptibility to infection with other viruses, including the hum
- Immunohistochemical versus molecular detection of RAK antigens in breast cancer.
- Exp Mol Pathol. 2000 Aug;69(1):27-36. Unique Identifier : AIDSLINE MED/20351364
- Kyriacou KC; Iacovou F; Adamou A; Hadjisavvas A; Rakowicz-Szulczynska EM; The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
- RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by HIV-1 and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men. Binding of the monoclonal antibody (MAb) RAK-BrI to cancer RAK antigens has been found to be inhib
- Human immunodeficiency virus-associated malignant lymphoma in eastern Denmark diagnosed from 1990-1996: clinical features, histopathology, and association with Epstein-Barr virus and human herpesvirus-8.
- Eur J Haematol. 2000 Jun;64(6):368-75. Unique Identifier : AIDSLINE MED/20356768
- Hansen PB; Penkowa M; Kirk O; Skinhoj P; Pedersen C; Lisse I; Kiss K; Zhou X; Hamilton-Dutoit SJ; Department of Infectious Diseases, University of Copenhagen,; Rigshospitalet, Denmark.
- The clinicopathological features of human immunodeficiency virus (HIV)-associated lymphoma were investigated in a retrospective study of 85 adult patients in eastern Denmark diagnosed during the period 1990-1996. The possible pathog
- [Duodenal Burkitt lymphoma in an HIV-negative patient: a medical emergency (letter)]
- Gastroenterol Clin Biol. 2000 Apr;24(4):470-1. Unique Identifier : AIDSLINE MED/20304716
- Foa C; Magne N; Francois E; Peroux JL; Pivot X; Thyss A
- Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group [see comments]
- Gastroenterology. 2000 Jul;119(1):172-80. Unique Identifier : AIDSLINE MED/20349425
- Liaw YF; Leung NW; Chang TT; Guan R; Tai DI; Ng KY; Chien RN; Dent J; Roman L; Edmundson S; Lai CL; Liver Research Unit, Chang Gung Memorial Hospital and University,; Taipei, Taiwan. liveryfl@tp.silkera.net
- BACKGROUND & AIMS: One-year lamivudine therapy significantly suppressed hepatitis B virus (HBV) replication, improved hepatic necroinflammatory activity, and prevented progression of fibrosis. However, the effects of prolonged therapy are unknown. METHODS: A total of 334 Asian patients with chronic hepatitis B from
- Lamivudine therapy for chronic hepatitis B: is longer duration of treatment better? [editorial; comment]
- Gastroenterology. 2000 Jul;119(1):263-6. Unique Identifier : AIDSLINE MED/20349439
- Lok AS
- Breath alkanes as a marker of oxidative stress in different clinical conditions.
- Free Radic Biol Med. 2000 Mar 15;28(6):880-6. Unique Identifier : AIDSLINE MED/20263790
- Aghdassi E; Allard JP; Department of Medicine, The Toronto Hospital, General Division,; Toronto, Canada.
- We assessed oxidative stress in three different clinical conditions: smoking, human immunodeficiency virus (HIV) infection, and inflammatory bowel disease, using breath alkane output and other lipid peroxidation parameters such as plasma lipid peroxides (LPO) and malondialdehyde (MDA). Antioxidant micronutrients such
- [Prophylaxis after occupational exposure to HIV]
- Harefuah. 2000 Apr 16;138(8):671-7. Unique Identifier : AIDSLINE MED/20339425
- Torten D; Bentwich Z
- The cost-effectiveness of prophylaxis for Mycobacterium avium complex in AIDS.
- Int J Technol Assess Health Care. 1999 Summer;15(3):531-47. Unique Identifier : AIDSLINE MED/20332554
- Scharfstein JA; Paltiel AD; Weinstein MC; Seage GR; Losina E; Craven DE; Freedberg KA; Johns Hopkins School of Public Health, USA.
- OBJECTIVE: To develop a simulation model to project costs, life expectancy, and cost-effectiveness in discounted dollars per quality-adjusted life-year (QALY) saved for clinical strategies to prevent Mycobacterium avium complex (MAC) in patients with AIDS. METHODS: We used natural history data from the Multicenter AID
- Health care participation of perinatal women with HIV: what helps and what gets in the way?
- Health Care Women Int. 1999 Nov-Dec;20(6):563-78. Unique Identifier : AIDSLINE MED/20348076
- Bunting SM; Seaton R; Medical College of Georgia School of Nursing, Department of; Community Nursing, Augusta 30912-4250, USA. sbunting@mail.mcg.edu
- Dealing with the reality of the human immunodeficiency virus (HIV) is a life-changing challenge to perinatal women as they try to care for themselves and their children in environments that often include stigma, uncertainty, and limited access to information and health care. Our purpose for this interpretive hermeneut
- Perceived HIV-related sexual risks and prevention practices of African American women in the southeastern United States.
- Health Care Women Int. 1999 Nov-Dec;20(6):579-91. Unique Identifier : AIDSLINE MED/20348077
- Timmons SM; Sowell RL; College of Nursing, University of South Carolina, Columbia, USA.; stimmons1@aol.com
- African American women in the southeastern United States constitute the fastest growing segment of those infected with the human immunodeficiency virus (HIV). Little data exist about the relationships between HIV infection risks and preventive practices. In this article, we describe a
- Preventing perinatal HIV: prenatal HIV testing and strategies to reduce the risk of maternal--fetal HIV transmission.
- J Ark Med Soc. 2000 Jun;97(1):27-8. Unique Identifier : AIDSLINE MED/20345952
- Saccente M; Division of AIDS/STD, Arkansas Department of Health, USA.
- AIDS, anemia, and an abnormal platelet count.
- Hosp Pract (Off Ed). 1999 Sep 15;34(10):39-40. Unique Identifier : AIDSLINE MED/20360204
- Fisher LR; Shah RP; Adelman HM; University of South Florida, USA.
- Validation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance.
- J Chromatogr Sci. 2000 Jun;38(6):246-54. Unique Identifier : AIDSLINE MED/20346802
- Li QC; Tougas T; Cohen K; Lee R; Meagan P; Corson M; Muchnick T; Analytical Sciences Department, Research and Development Center,; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877,; USA.
- Nevirapine ( Viramune ), a dipyridiodiazepinone, is a potent and highly specific nonnucleoside inhibitor of HIV-1 reverse transcriptase. This paper describes the validation of a specific, sensitive, and stability-indicating high-performance liquid chrom
- Immunoflow cytometry and cell block immunohistochemistry in the FNA diagnosis of lymphoma: a review of 73 consecutive cases.
- J Clin Pathol. 2000 Jun;53(6):451-7. Unique Identifier : AIDSLINE MED/20369456
- Mayall F; Dray M; Stanley D; Harrison B; Allen R; Department of Pathology, Waikato Hospital, Hamilton, New Zealand.; mayallf@hwl.co.nz
- AIMS: To review the results of 73 consecutive fine needle aspirations (FNAs) that were collected by a pathologist and analysed by immunoflow cytometry. Material for a cell block was also collected from some of these lesions. METHODS: The setting was a large general hospital in rural
- Immunomodulatory therapy in the management of viral infections in patients with HIV infection.
- Unique Identifier : AIDSLINE MED/20318631
- Conant MA; University of California Medical Center, San Francisco, CA, USA.
- Human immunodeficiency virus (HIV) causes disease by infecting lymphocytes and progressively destroying critical regulatory and effector cells of the immune system, leaving patients vulnerable to a number of bacterial, fungal, and viral infections. Facial herpes (herpes simplex virus-1 [HSV-1]),
- Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4.
- J Immunol. 2000 Jul 1;165(1):10-4. Unique Identifier : AIDSLINE MED/20318692
- Zhang S; Lukacs NW; Lawless VA; Kunkel SL; Kaplan MH; Department of Microbiology and Immunology, Walther Oncology; Center, Indiana University School of Medicine, Indianapolis; 46208, USA.
- The in vivo function of Th cell subsets is largely dependent on the ability of differentiated CD4+ T cells to be recruited to specific sites and secrete restricted sets of cytokines. In this paper we demonstrate that Th1 and Th2 cells secrete discrete patterns of chemokines, small m.w. cytokines that function as chemo
- Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA.
- J Immunol. 2000 Jul 1;165(1):148-57. Unique Identifier : AIDSLINE MED/20318711
- Liao HX; Montefiori DC; Patel DD; Lee DM; Scott WK; Pericak-Vance M; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA. hliao@duke.edu'
- A 32-bp deletion in CCR5 (CCR5 Delta 32) confers to PBMC resistance to HIV-1 isolates that use CCR5 as a coreceptor. To study this mutation in T cell development, we have screened 571 human thymus tissues for the mutation. We identified 72 thymuses (12.6%) that were heterozygous and 2 (0.35%) that were homozygous for
- Dendritic cells in the induction of protective and nonprotective anticryptococcal cell-mediated immune responses.
- ptors, Cell Surface/ANALYSIS Support, U.S. Gov't, P.H.S. Survival Analysis T-Lymphocytes/IMMUNOLOGY Vaccines, Inactivated/ADMINISTRATION & DOSAGE/IMMUNOLOGY J Immunol. 2000 Jul 1;165(1):158-67. Unique Identifier : AIDSLINE MED/20318712
- Bauman SK; Nichols KL; Murphy JW; Department of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City 73190, USA.
- Epithelial cell-specific laminin 5 is required for survival of early thymocytes.
- J Immunol. 2000 Jul 1;165(1):192-201. Unique Identifier : AIDSLINE MED/20318716
- Kim MG; Lee G; Lee SK; Lolkema M; Yim J; Hong SH; Schwartz RH; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892, USA.; mkim@plaza1.snu.ac.kr
- The gene LamC2 encoding the gamma2 chain of laminin 5, an epithelial cell-specific extracellular matrix protein, was identified in a PCR-based subtracted cDNA library from mouse thymic stromal cells. The mRNA existed in two alternative forms (5.1 and 2.4 kb). The full-length message was highly expressed in SCID thymus
- Systemic administration of agonist peptide blocks the progression of spontaneous CD8-mediated autoimmune diabetes in transgenic mice without bystander damage.
- J Immunol. 2000 Jul 1;165(1):202-10. Unique Identifier : AIDSLINE MED/20318717
- Bercovici N; Heurtier A; Vizler C; Pardigon N; Cambouris C; Desreumaux P; Liblau R; Laboratoire d'Immunologie Cellulaire, Institut National de la; Sante et de la Recherche Medicale CJF 9711, Paris, France.
- Insulin-dependent diabetes is an autoimmune disease targeting pancreatic beta-islet cells. Recent data suggest that autoreactive CD8+ T cells are involved in both the early events leading to insulitis and the late destructive phase resulting in diabetes. Although therapeutic injection of protein and synthetic peptides
- An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts.
- J Immunol. 2000 Jul 1;165(1):247-55. Unique Identifier : AIDSLINE MED/20318722
- Diamond AS; Gill RG; Department of Immunology and Medicine, Childhood Diabetes,; University of Colorado Health Sciences Center, Denver 80262, USA.
- CD8+ T cells have long been considered to be the prototypical cytotoxic lymphocyte subpopulation. However, whether alloreactive CD8+ T cells require traditional cytolytic pathways such as perforin and Fas ligand (FasL) to mediate graft rejection has been a controversial issue. In the present studies, we examined the r
- T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.
- J Immunol. 2000 Jul 1;165(1):25-33. Unique Identifier : AIDSLINE MED/20318695
- Sandberg JK; Franksson L; Sundback J; Michaelsson J; Petersson M; Achour A; Wallin RP; Sherman NE; Bergman T; Jornvall H; Hunt DF; Kiessling R; Karre K; Microbiology and Tumor Biology Center and Department of Medical; Biochemistry and Biophysics, Karolinska Institutet, Stockholm,; Sweden. jsandber@adarc.adarc.org
- Given the flexible nature of TCR specificity, deletion or permanent disabling of all T cells with the capacity to recognize self peptides would severely limit the diversity of the repertoire and the capacity to recognize foreign Ags. To address this, we have investigated the patterns of CD8+ CTL reactivity to a natura
- The HTLV-I tax protein transcriptionally modulates OX40 antigen expression.
- J Immunol. 2000 Jul 1;165(1):263-70. Unique Identifier : AIDSLINE MED/20318724
- Pankow R; Durkop H; Latza U; Krause H; Kunzendorf U; Pohl T; Bulfone-Paus S; Departments of Pathology and Urology, University Hospital; Benjamin Franklin, Free University Berlin, Germany.
- OX40 is a member of the TNF receptor family, expressed on activated T cells. It is the only costimulatory T cell molecule known to be specifically up-regulated in human T cell leukemia virus type-I (HTLV-I)-producing cells. In a T cell line, OX40 surface expression was shown to be induced by HTLV-I Tax alone. To under
- IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection.
- J Immunol. 2000 Jul 1;165(1):364-72. Unique Identifier : AIDSLINE MED/20318737
- Jones DE; Buxbaum LU; Scott P; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia 19104, USA.
- Leishmania amazonensis induces a nonhealing infection in C3H mice, whereas infection with Leishmania major is self-healing. We found that C3H mice infected with L. amazonensis exhibited decreased IL-12 production, which could account for the susceptibility to this organism. However, exogenous IL-12 administration fail
- T cell vaccination in mice with invasive pulmonary aspergillosis.
- J Immunol. 2000 Jul 1;165(1):381-8. Unique Identifier : AIDSLINE MED/20318739
- Cenci E; Mencacci A; Bacci A; Bistoni F; Kurup VP; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.
- Aspergillus fumigatus, an opportunistic fungal pathogen, is responsible for multiple airway diseases of an allergic and a nonallergic nature. In a murine model of invasive pulmonary aspergillosis, resistance is associated with a decreased lung inflammatory pathology and the occurrence of an IL-12-dependent Th1-type re
- Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice.
- J Immunol. 2000 Jul 1;165(1):5-9. Unique Identifier : AIDSLINE MED/20318691
- White DW; Badovinac VP; Kollias G; Harty JT; Interdisciplinary Graduate Program in Immunology, University of; Iowa, Iowa City 52242, USA.
- The mechanisms by which CD8+ T cells mediate immunity against bacterial pathogens remain largely unknown. Perforin-dependent cytolysis plays a role, but is not required for CD8+ T cell-mediated immunity against Listeria monocytogenes. TNF is essential for CD8+ T cell immunity to L. monocytogenes, but the cellular sour
- Mechanism of paclitaxel activity in Kaposi's sarcoma.
- J Immunol. 2000 Jul 1;165(1):509-17. Unique Identifier : AIDSLINE MED/20318754
- Sgadari C; Toschi E; Palladino C; Barillari G; Carlei D; Cereseto A; Ciccolella C; Yarchoan R; Monini P; Sturzl M; Ensoli B; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
- Kaposi s sarcoma (KS) is an angioproliferative disease characterized by proliferation of spindle-shaped cells predominantly of endothelial cell origin, neoangiogenesis, inflammatory cell infiltration, and edema. At least in early stage, KS behaves as a reactive lesion sustained by the action of inflammatory cytokines
- Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
- Unique Identifier : AIDSLINE MED/20318755
- Wagar EJ; Cromwell MA; Shultz LD; Woda BA; Sullivan JL; Hesselton RM; Greiner DL
- Human PBMC engraft in mice homozygous for the severe combined immunodeficiency (Prkdcscid) mutation (Hu-PBL-scid mice). Hu-PBL-NOD-scid mice generate 5- to 10-fold higher levels of human cells than do Hu-PBL-C.B-17-scid mice, and Hu-PBL-NOD-scid beta2-microglobulin-null (NOD-scid-B2mnull) mice support even higher leve
- Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.
- J Immunol. 2000 Jul 1;165(1):533-8. Unique Identifier : AIDSLINE MED/20318757
- Valmori D; Dutoit V; Lienard D; Lejeune F; Speiser D; Rimoldi D; Cerundolo V; Dietrich PY; Cerottini JC; Romero P; Division of Clinical Onco-Immunology, Ludwig Institute for Cancer; Research, Lausanne Branch, University Hospital, Switzerland.; danila.valmori@inst.hospvd.ch
- The assessment of the TCR repertoire expressed by tumor-specific CD8+ T lymphocytes has been hampered to date by the difficulty of targeting the analysis to lymphocytes directed against a single epitope. In the present study we have used fluorescent A2/Melan-A tetramers in conjunction with anti-CD8 and anti-TCR beta-c
- Anti-TCR-specific DNA vaccination demonstrates a role for a CD8+ T cell clone in the induction of allograft tolerance by donor-specific blood transfusion.
- J Immunol. 2000 Jul 1;165(1):96-101. Unique Identifier : AIDSLINE MED/20318704
- Vignes C; Chiffoleau E; Douillard P; Josien R; Peche H; Heslan JM; Usal C; Soulillou JP; Cuturi MC; Institut National de la Sante et de la Recherche Medicale; Unite 437 "Immunointervention dans les allo-et; xeno-transplantations" and Institut de Transplantation et de; Recherche en Transplantation, Nantes, France.
- Donor-specific allograft tolerance can be induced in the adult rat by pregraft donor-specific blood transfusion (DST). This tolerance appeared to be mediated by regulatory cells and to the production of the suppressive cytokine TGF-beta1. A potential immunoregulatory CD8+ clone bearing a Vbeta18-Dbeta1-Jbeta2.7 TCR ge
- Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice.
- J Immunol. 2000 Jul 15;165(2):1022-9. Unique Identifier : AIDSLINE MED/20341707
- Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD; Department of Medicine, Pathology, and Comparative Medicine,; University of Alabama, Birmingham, AL 35294, USA.
- To elucidate the pathogenesis of Helicobacter pylori-associated gastritis, we studied immune responses of C57BL/6J wild-type (WT), SCID, and gene deficient (IFN-gamma-/- and IL-4-/-) mice following infection with a pathogenic isolate of H. pylori (SPM326). During early infection in WT mice, mononuclear and polymorphon
- Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.
- J Immunol. 2000 Jul 15;165(2):1074-81. Unique Identifier : AIDSLINE MED/20341714
- Flano E; Husain SM; Sample JT; Woodland DL; Blackman MA; Department of Immunology, Program in Viral Oncogenesis and Tumor; Immunology, St. Jude Children's Research Hospital, Memphis, TN; 38105, USA.
- Intranasal infection of mice with the murine gamma-herpesvirus MHV-68 results in an acute lytic infection in the lung, followed by the establishment of lifelong latency. Development of an infectious mononucleosis-like syndrome correlates with the establishment of latency and is characterized by splenomegaly and the ap
- Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors.
- J Immunol. 2000 Jul 15;165(2):1082-92. Unique Identifier : AIDSLINE MED/20341715
- Gea-Banacloche JC; Migueles SA; Martino L; Shupert WL; McNeil AC; Sabbaghian MS; Ehler L; Prussin C; Stevens R; Lambert L; Altman J; Hallahan CW; de Quiros JC; Connors M; Laboratories ofImmunoregulation and Allergic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, MD 20892, USA.
- The virus-specific CD8+ T cell responses of 21 HIV-infected patients were studied including a unique cohort of long-term nonprogressors with low levels of plasma viral RNA and strong proliferative responses to HIV Ags. HIV-specific CD8+ T cell responses were studied by a combination of standard cytotoxic T cell (CTL)
- Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes.
- J Immunol. 2000 Jul 15;165(2):1102-10. Unique Identifier : AIDSLINE MED/20341717
- Cameron MJ; Arreaza GA; Grattan M; Meagher C; Sharif S; Burdick MD; Strieter RM; Cook DN; Delovitch TL; Autoimmunity/Diabetes Group, The John P. Robarts Research; Institute, London, Ontario, Canada.
- We investigated the biological role of CC chemokines in the Th1-mediated pathogenesis of spontaneous type I diabetes in nonobese diabetic (NOD) mice. Whereas an elevated ratio of macrophage inflammatory protein-1alpha (MIP-1alpha):MIP-1beta in the pancreas correlated with destructive insulitis and progression to diabe
- CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection.
- J Immunol. 2000 Jul 15;165(2):1111-8. Unique Identifier : AIDSLINE MED/20341718
- Jones ND; Van Maurik A; Hara M; Spriewald BM; Witzke O; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, Oxford, United Kingdom.; nicholas.jones@surgery.ox.ac.uk
- In experimental transplantation, blockade of CD40-CD40 ligand (CD40L) interactions has proved effective at permitting long-term graft survival and has recently been approved for clinical evaluation. We show that CD4+ T cell-mediated rejection is prevented by anti-CD40L mAb therapy but that CD8+ T cells remain fully fu
- Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii.
- J Immunol. 2000 Jul 15;165(2):628-31. Unique Identifier : AIDSLINE MED/20341661
- Yap G; Pesin M; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, MD 20892, USA.
- IL-12 is required for the development of IFN-gamma-dependent resistance to intracellular pathogens but is not thought to play a major role in its maintenance. To directly assess the requirement for continuous IL-12 signaling in long-term cell-mediated immunity, recombinant cytokine was transiently administered to IL-1
- Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes.
- J Immunol. 2000 Jul 15;165(2):632-6. Unique Identifier : AIDSLINE MED/20341662
- Venkataraman C; Schaefer G; Schindler U; Tularik, South San Francisco, CA 94080, USA.
- Development of naive Th cells into Th1 and Th2 effector populations requires coordinated expression of a complex set of genes. In this study, we have identified a novel four-transmembrane domain protein, Chandra, that is differentially expressed in Th1 cells. Chandra expression is observed in STAT4- and IFN-gamma-defi
- Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell.
- J Immunol. 2000 Jul 15;165(2):680-90. Unique Identifier : AIDSLINE MED/20341668
- Kasprowicz DJ; Kohm AP; Berton MT; Chruscinski AJ; Sharpe A; Sanders VM; Departments of Microbiology and Immunology, and Cell Biology,; Neurobiology and Anatomy, Loyola University Medical Center,; Maywood, IL 60153, USA.
- Our findings using B cells from either wild-type, CD86-deficient, or beta 2-adrenergic receptor (beta2AR)-deficient mice suggest three mechanisms by which the level of IgG1 and IgE production can be increased on a per cell basis. Trinitrophenyl-specific B cells enriched from unimmunized mouse spleens were pre-exposed
- Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells.
- J Immunol. 2000 Jul 15;165(2):716-24. Unique Identifier : AIDSLINE MED/20341672
- Jourdan P; Vendrell JP; Huguet MF; Segondy M; Bousquet J; Pene J; Yssel H; Institut National de la Sante et de la Recherche Medicale Unite; 454, Montpellier, France.
- In the present study, we show that IL-2 , IL-4, IL-7, and IL-15 are able to induce functional CXCR4 surface expression on resting in vitro-generated CD4+ CXCR4- CCR7+ memory T cells. Cytokine-mediated induction of CXCR4 expression was associated with an increase in CXCR
- Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow.
- J Immunol. 2000 Jul 15;165(2):725-33. Unique Identifier : AIDSLINE MED/20341673
- Kohm AP; Tang2 Y; Sanders VM; Jones3 SB; Department of Cell Biology, The Burn and Shock Trauma Institute,; Loyola University Medical Center, Maywood, IL 60153, USA.
- The neurotransmitter norepinephrine (NE) binds to the beta 2-adrenergic receptor (beta 2AR) expressed on various immune cells to influence cell homing, proliferation, and function. Previous reports showed that NE stimulation of the B cell beta 2AR is necessary for the maintenance of an optimal primary and secondary Th
- Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization.
- J Immunol. 2000 Jul 15;165(2):750-9. Unique Identifier : AIDSLINE MED/20341676
- Kumaraguru U; Rouse RJ; Nair SK; Bruce BD; Rouse BT; Department of Microbiology, University of Tennessee, Knoxville,; TN 37996, USA.
- Immunization with plasmid DNA holds promise as a vaccination strategy perhaps useful in situations that currently lack vaccines, since the major means of immune induction may differ from more conventional approach. In the present study, we demonstrate that exposure of macrophages to plasmid DNA encoding viral proteins
- IL-12 is required to maintain a Th1 response during Leishmania major infection.
- J Immunol. 2000 Jul 15;165(2):896-902. Unique Identifier : AIDSLINE MED/20341692
- Park AY; Hondowicz BD; Scott P; Department of Pathobiology, University of Pennsylvania School of; Veterinary Medicine, Philadelphia, PA 19104, USA.
- IL-12 initiates Th1 cell development and cell-mediated immunity, but whether IL-12 contributes to the maintenance of a Th1 response is unclear. To address this question, we infected IL-12 p40-/- C57BL/6 mice with Leishmania major, an intracellular protozoan parasite controlled by a cell-mediated immune response, and s
- Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.
- J Immunol. 2000 Jul 15;165(2):915-24. Unique Identifier : AIDSLINE MED/20341694
- Gurunathan S; Stobie L; Prussin C; Sacks DL; Glaichenhaus N; Fowell DJ; Locksley RM; Chang JT; Wu CY; Seder RA; Clinical Immunology Section, Laboratory of Clinical; Investigation, National Institute of Allergy and Infectious; Diseases, Niational Institutes of Health, Bethesda, MD 20892,; USA.
- Protective immunity against Leishmania major generated by DNA encoding the LACK (Leishmania homologue of receptor for activated C kinase) Ag has been shown to be more durable than vaccination with LACK protein plus IL-12. One mechanism to account for this may be the selective ability of DNA vaccination to induce CD8+
- Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction.
- J Immunol. 2000 Jul 15;165(2):925-30. Unique Identifier : AIDSLINE MED/20341695
- Lewinsohn DM; Briden AL; Reed SG; Grabstein KH; Alderson MR; Division of Pulmonary and Critical Care Medicine, Oregon Health; Sciences, University/Portland Veterans Affairs Medical Center,; Portland, OR 97201, USA. lewinsod@OHSU.edu
- Previous studies in mice and humans models have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). In humans, CD8+ Mtb-reactive T cells have been described that are HLA-A2-, B52-, as well as CD1-restricted. Recently, we have described Mtb-specific CD8+ T cells that are ne
- IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.
- J Immunol. 2000 Jul 15;165(2):941-7. Unique Identifier : AIDSLINE MED/20341697
- Kawakami K; Koguchi Y; Qureshi MH; Miyazato A; Yara S; Kinjo Y; Iwakura Y; Takeda K; Akira S; Kurimoto M; Saito A; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; kawakami@med.u-ryukyu.ac.jp
- The aim of this study was to examine the contribution of IL-18 in host defense against infection caused by Cryptococcus neoformans in mice with defective IL-12 production. Experiments were conducted in mice with a targeted disruption of the gene for IL-12p40 subunit (IL-12p40-/- mice). In these mice, host resistance w
- Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen.
- J Immunol. 2000 Jul 15;165(2):956-61. Unique Identifier : AIDSLINE MED/20341699
- Ohta A; Sekimoto M; Sato M; Koda T; Nishimura S; Iwakura Y; Sekikawa K; Nishimura T; Division of Immunoregulation, Section of Disease Control,; Institute for Genetic Medicine, and Division of Biological; Sciences, Graduate School of Science, Hokkaido University,; Sapporo, Japan.
- We report the development and characterization of a novel model of severe hepatitis induced against hepatitis B virus surface Ag (HBsAg). HBsAg was successfully targeted into the liver in soluble form. Using this unique property of HBsAg, we established a liver injury model induced by HBsAg-specific Th1 cells. Severe
- Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity.
- J Immunol Methods. 2000 Jun 23;240(1-2):143-55. Unique Identifier : AIDSLINE MED/20314647
- Rininsland FH; Helms T; Asaad RJ; Boehm BO; Tary-Lehmann M; Institute of Pathology, School of Medicine, Case Western Reserve; University, Cleveland, OH 44106, USA.
- A major goal in immunodiagnostics has been the development of assay systems that can measure CD8(+) T cell immunity in humans, directly ex vivo, at high resolution, and with high throughput. We established granzyme B (grB) enzyme-linked immunospot assay (ELISPOT) in conjunction with image analysis to this end. Using g
- Pain and pain treatment in AIDS patients: a longitudinal study.
- Unique Identifier : AIDSLINE MED/20330185
- Frich LM; Borgbjerg FM
- To determine the prevalence, incidence, and characteristics of pain connected with AIDS, 95 AIDS patients were enrolled in a prospective longitudinal study and interviewed every six months during a 2-year period or until death. The overall incidence of pain was 88%, and 69% of the patients suffered from constant pain
- T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.
- J Exp Med. 2000 Jun 5;191(11):1869-79. Unique Identifier : AIDSLINE MED/20298894
- Yamashita M; Katsumata M; Iwashima M; Kimura M; Shimizu C; Kamata T; Shin T; Seki N; Suzuki S; Taniguchi M; Nakayama T; Department of Developmental Immunology, Chiba University School; of Medicine, Japan.
- The activation of downstream signaling pathways of both T cell receptor (TCR) and interleukin 4 receptor (IL-4R) is essential for T helper type 2 (Th2) cell development, which is central to understanding immune responses against helminthic parasites and in allergic and autoimmune diseases. However, little is known abo
- Effects of in vivo CD8(+) T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine.
- J Exp Med. 2000 Jun 5;191(11):1921-31. Unique Identifier : AIDSLINE MED/20298898
- Metzner KJ; Jin X; Lee FV; Gettie A; Bauer DE; Di Mascio M; Perelson AS; Marx PA; Ho DD; Kostrikis LG; Connor RI; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, NY 10016, USA.
- The role of CD8(+) T lymphocytes in controlling replication of live, attenuated simian immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the correlates of protection in the SIV/rhesus macaque model. Rhesus macaques immunized for >2 yr with nef-deleted SIV (SIVmac239Deltanef) and prote
- Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.
- J Exp Med. 2000 Jun 5;191(11):1987-97. Unique Identifier : AIDSLINE MED/20298904
- Riley JL; Schlienger K; Blair PJ; Carreno B; Craighead N; Kim D; Carroll RG; June CH; Department of Molecular and Cellular Engineering, University of; Pennsylvania, Philadelphia 19104, USA.
- CD4 T cells activated in vitro by anti-CD3/28-coated beads are resistant to infection by CC chemokine receptor 5 (CCR5)-dependent HIV-1 isolates. In vivo, antigen-presenting cells (APCs) activate CD4 T cells in part by signaling through the T cell receptor and CD28, yet cells stimulated in this manner are susceptible
- Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIV(R29) isolate.
- J Gen Virol. 2000 Jun;81 Pt 6:1463-72. Unique Identifier : AIDSLINE MED/20273992
- Carpenter S; Vaughn EM; Yang J; Baccam P; Roth JA; Wannemuehler Y; Department of Veterinary Microbiology and Preventive Medicine,; College of Veterinary Medicine, Interdepartmental Genetics; Program, Iowa State University, Ames, IA 50011, USA.; scarp@iastate.edu
- Experimental infection of cattle with bovine immunodeficiency virus (BIV) is characterized by persistent, low levels of virus replication in the absence of clinical disease. A virus neutralization (VN) assay was developed to examine the role of VN antibodies in controlling virus replication in cattle experimentally in
- Phase II evaluation of thalidomide in patients with metastatic breast cancer.
- Unique Identifier : AIDSLINE MED/20355117
- Baidas SM; Winer EP; Fleming GF; Harris L; Pluda JM; Crawford JG; Yamauchi H; Isaacs C; Hanfelt J; Tefft M; Flockhart D; Johnson MD; Hawkins MJ; Lippman ME; Hayes DF
- PURPOSE: To determine the efficacy, safety, pharmacokinetics, and effect on serum angiogenic growth factors of two dose levels of thalidomide in patients with metastatic breast cancer. PATIENTS
- Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1.
- J Pediatr. 2000 Jul;137(1):78-84. Unique Identifier : AIDSLINE MED/20351503
- Madhi SA; Schoub B; Simmank K; Blackburn N; Klugman KP; SAIMR/Wits/MRC Pneumococcal Diseases Research Unit, National; Institute for Virology, the Department of Paediatrics, Chris; Hani-Baragwanath Hospital, University of the Witwatersrand,; Johannesburg, South Africa.
- OBJECTIVES: To determine the burden of viral associated severe lower respiratory tract infections (SLRTI) in human immunodeficiency virus-infected (HIV+) and HIV-uninfected (HIV-) urban black South African children. METHODS: Children with SLRTI aged 2 to 60 months were enrolled between March 1997 and March 1998. Monoc
- Prenatal indicators of congenital cytomegalovirus infection [see comments]
- J Pediatr. 2000 Jul;137(1):90-5. Unique Identifier : AIDSLINE MED/20351505
- Lazzarotto T; Varani S; Guerra B; Nicolosi A; Lanari M; Landini MP; Department of Clinical and Experimental Medicine, the University; of Bologna, Italy.
- OBJECTIVE: To assess the validity of a diagnostic protocol designed to predict the outcome of newborns of mothers suspected to have primary cytomegalovirus ( CMV ) infection during the first 4 months of pregnancy. STUDY DESIGN:
- Pediatric home care: reimbursement and cost benefit analysis.
- J Pediatr Health Care. 1999 Nov-Dec;13(6 Pt 1):288-94. Unique Identifier : AIDSLINE MED/20348117
- Balinsky W; Milano Graduate School of Management, Health Services Management; and Policy, New School University, New York, NY, USA.
- Home care has been described as the fastest growing component of personal health care spending, and pediatric home care as the fastest growing segment of the home care field. Because of the continued progress in pediatric medicine and advances in technology, a growing population of children with complex chronic and te
- Transport of cosalane-a highly lipophilic novel anti-HIV agent-across caco-2 cell monolayers.
- J Pharm Sci. 2000 Jun;89(6):826-33. Unique Identifier : AIDSLINE MED/20285423
- Pal D; Udata C; Mitra AK; Division of Pharmaceutical Sciences, School of Pharmacy,; University of Missouri-Kansas City, 5005 Rockhill Road, Kansas; City, Missouri 64110, USA.
- Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral bioavailability of this highly lipophilic compound is extremely poor (
- Biotypes of oral Candida albicans isolated from AIDS patients and HIV-free subjects in Thailand.
- J Oral Pathol Med. 2000 May;29(5):193-9. Unique Identifier : AIDSLINE MED/20258973
- Teanpaisan R; Nittayananta W; Chongsuvivatwong V; Department of Stomatology, Faculty of Dentistry, Prince of; Songkla University, Hat-Yai, Thailand.
- This study was conducted to examine biotypes and antifungal susceptibility patterns of oral Candida albicans isolated from HIV-infected patients, HIV-free patients with candidiasis and healthy subjects. All isolates were biotyped using a typing system based on enzyme profiles, carbohydrate assimilation patterns and bo
- Discriminative immunophenotype of bronchoalveolar lavage CD4 lymphocytes in sarcoidosis.
- Lab Invest. 2000 Jul;80(7):1065-9. Unique Identifier : AIDSLINE MED/20363443
- Kolopp-Sarda MN; Kohler C; De March AK; Bene MC; Faure G; Laboratoire d'Immunologie, Faculte de Medecine and CHU de; Nancy, France. mkolopps@grip.u-nancy.fr
- The diagnosis of pulmonary sarcoidosis relies in part on the observation of alveolar CD4+ lymphocytosis. However, this criterion is not fully discriminative because this anomaly is also found in other types of lung diseases. Among other possible distinctive criteria, we investigated the expression of lymphocyte-addres
- Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor).
- Lab Invest. 2000 Jul;80(7):1121-6. Unique Identifier : AIDSLINE MED/20363450
- Gomez-Roman JJ; Ocejo-Vinyals G; Sanchez-Velasco P; Nieto EH; Leyva-Cobian F; Val-Bernal JF; Departamento de Anatomia Patologica, Hospital Universitario; Marques de Valdecilla, Instituto Nacional de la Salud, Facultad; de Medicina, Universidad de Cantabria, Santander, Spain.
- Inflammatory myofibroblastic tumor (IMT) is composed of myofibroblasts, plasma cells, and lymphocytes. Cytokines are possibly involved in its pathogenesis. Human herpesvirus-8 (HHV-8) encodes cell cycle regulatory and signaling proteins. A combination of nested PCR with several negative controls and Southern blot meth
- Flow cytometric study of lymphocytes associated with thymoma and other thymic tumors.
- J Surg Res. 1999 Apr;82(2):312-8. Unique Identifier : AIDSLINE MED/99192629
- Fujii Y; Okumura M; Yamamoto S; Department of Surgery II, Nagoya City University Medical School,; Nagoya, Japan. yosfujii@med.nagoya-cu.ac.jp
- BACKGROUND. A large number of immature T lymphocytes in thymoma may reflect the biological function of the neoplastic epithelial cells. However, to confirm that this lymphocyte-inducing activity is unique to thymoma, lymphocytes associated with other thymic tumors need to be studied. MATERIALS AND METHODS. We used flo
- Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma.
- Lancet. 2000 May 13;355(9216):1680-3. Unique Identifier : AIDSLINE MED/20361178
- Gereda JE; Leung DY; Thatayatikom A; Streib JE; Price MR; Klinnert MD; Liu AH; Division of Pediatric Allergy & Immunology, National Jewish; Medical & Research Center, Denver, CO 80206, USA.
- BACKGROUND: Bacterial endotoxin is known to induce interferon gamma and interleukin 12 production, and therefore has the potential to decrease allergen sensitisation. To find out the role of early chronic endotoxin exposure in the development of allergen sensitisation and asthma, we compared concentrations of endotoxi
- Tanzanian AIDS project works towards "good things for young people" [news]
- Lancet. 2000 May 13;355(9216):1703. Unique Identifier : AIDSLINE MED/20361189
- Fox R
- Ireland's infected blood products inquiry begins [news]
- Lancet. 2000 May 13;355(9216):1705. Unique Identifier : AIDSLINE MED/20361191
- Birchard K
- HIV in Latin America and the Caribbean [editorial] [published erratum appears in Lancet 2000 Aug 12;356(9229):600]
- Lancet. 2000 Jun 17;355(9221):2087. Unique Identifier : AIDSLINE MED/20358410
- Extent to which low-level use of antiretroviral treatment could curb the AIDS epidemic in sub-Saharan Africa [see comments]
- Lancet. 2000 Jun 17;355(9221):2095-100. Unique Identifier : AIDSLINE MED/20358417
- Wood E; Braitstein P; Montaner JS; Schechter MT; Tyndall MW; O'Shaughnessy MV; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.
- BACKGROUND: Despite growing international pressure to provide HIV-1 treatment to less-developed countries, potential demographic and epidemiological impacts have yet to be characterised. We modelled the future impact of antiretroviral use in South Africa from 2000 to 2005. METHODS
- Promotion of condom use in a high-risk setting in Nicaragua: a randomised controlled trial [see comments]
- Lancet. 2000 Jun 17;355(9221):2101-5. Unique Identifier : AIDSLINE MED/20358418
- Egger M; Pauw J; Lopatatzidis A; Medrano D; Paccaud F; Smith GD; Department of Social Medicine, University of Bristol, UK.; m.egger@bristol.ac.uk
- BACKGROUND: In Latin America, motels rent rooms for commercial and non-commercial sex. We investigated the impact of providing health-education material and condoms on condom use in Managua, Nicaragua . METHODS: In a randomised controlled trial, in 19 motels, we gave condoms on r
- 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial.
- Lancet. 2000 Jun 17;355(9221):2106-11. Unique Identifier : AIDSLINE MED/20358419
- French N; Nakiyingi J; Carpenter LM; Lugada E; Watera C; Moi K; Moore M; Antvelink D; Mulder D; Janoff EN; Whitworth J; Gilks CF; Liverpool School of Tropical Medicine, UK.
- BACKGROUND: Infection with Streptococcus pneumoniae is a frequent and serious problem for HIV-immunosuppressed adults. Vaccination is recommended in the USA and Europe, but there are no prospective data that show vaccine efficacy. METHODS: 1392 (937 female) HIV-1-infected adults in Entebbe,
- Pharmacological implications of lengthened in-utero exposure to nevirapine [letter]
- Lancet. 2000 Jun 17;355(9221):2134-5. Unique Identifier : AIDSLINE MED/20358425
- Taylor GP; Lyall EG; Back D; Ward C; Tudor-Williams G
- Given as a single dose to the mother during labour, nevirapine can protect the neonate from HIV-1 infection for up to 7 days. However, after maternal nevirapine therapy during pregnancy, neonatal plasma concentrations of nevirapine decline more rapidl
- Hit HIV-1 hard, but only when necessary [see comments]
- Lancet. 2000 Jun 17;355(9221):2147-52. Unique Identifier : AIDSLINE MED/20358438
- Harrington M; Carpenter CC; Treatment Action Group, New York, NY 10001, USA.; markharrington@aol.com
- Randomised, controlled trial data show that combination antiretroviral therapy for HIV-1 infection benefits people with CD4-cell counts less than 350 cells/microL. Based on currently known risks and benefits, we believe that if CD4-cell counts and viral load are monitored carefully, and highly active antiretroviral th
- The debate on HIV in Africa [letter; comment]
- Lancet. 2000 Jun 17;355(9221):2162. Unique Identifier : AIDSLINE MED/20358441
- Clumeck N
- The debate on HIV in Africa [letter; comment]
- Lancet. 2000 Jun 17;355(9221):2162. Unique Identifier : AIDSLINE MED/20358442
- O'Farrell N
- The debate on HIV in Africa [letter; comment]
- Lancet. 2000 Jun 17;355(9221):2162-3. Unique Identifier : AIDSLINE MED/20358443
- Stewart GT; de Harvey E; Fiala C; Herxheimer A; Kohntein K
- The debate on HIV in Africa [letter]
- Lancet. 2000 Jun 17;355(9221):2163. Unique Identifier : AIDSLINE MED/20358444
- Sonnabend J
- Cochlear implantation in auditory neuropathy.
- Laryngoscope. 1999 Feb;109(2 Pt 1):181-5. Unique Identifier : AIDSLINE MED/20346816
- Miyamoto RT; Kirk KI; Renshaw J; Hussain D; Department of Otolaryngology--Head and Neck Surgery, Indiana; University School of Medicine, Indianapolis 46202,