Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment [see comments]

Nat Med. 2000 Aug;6(8):904-9. Unique Identifier : AIDSLINE MED/20392581
Schuchert MJ; Wright RD; Colson YL; Department of Surgery, University of Pittsburgh Medical Center; Health System, University of Pittsburgh, Pittsburgh, Pennsylvania; 15261, USA.

Abstract: The facilitating cell is a rare CD8+ bone marrow subpopulation that can enhance allogeneic hematopoietic stem cell engraftment across complete major histocompatibility complex barriers without inducing acute graft-versus-host disease. Here we describe a CD3epsilon-associated complex on the facilitating cell surface that consists of the T-cell receptor beta-chain disulfide-linked to a previously unknown 33-kilodalton glycoprotein. Provisionally called FCp33, this glycoprotein does not represent any of the known protein chains or surrogates associated with CD3-T-cell receptor beta. Expression of this CD3-T-cell receptor beta-FCp33 complex directly correlates with the facilitating cell's functional ability to enhance allogeneic stem cell engraftment in vivo.

Keywords: JOURNAL ARTICLE Animal Antigens, CD3/CHEMISTRY/METABOLISM CD8-Positive T-Lymphocytes/*IMMUNOLOGY/TRANSPLANTATION Dimerization Disulfides/CHEMISTRY Graft Enhancement, Immunologic *Hematopoietic Stem Cell Transplantation Male Mice Mice, Inbred C57BL Mice, Knockout Protein Structure, Quaternary Receptors, Antigen, T-Cell, alpha-beta/*CHEMISTRY/GENETICS/ *METABOLISM Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Transplantation, Homologous

KWDjournalarticleanimalantigens,cd3/chemistry/metabolismcd8-positivet-lymphocytes/KWDimmunology/transplantationdimerizationdisulfides/chemistrygraftenhancement,immunologicKWDhematopoieticstemcelltransplantationmalemicemice,inbredc57blmice,knockoutproteinstructure,quaternaryreceptors,antigen,t-cell,alpha-beta/KWDchemistry/genetics/KWDmetabolismsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDtransplantation,homologous
Comment in: Nat Med 2000 Aug;6(8):866-7
001130
A00B1191

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