Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Int J Mol Med. 2000 Sep;6(3):265-9. Unique Identifier : AIDSLINE MED/20394235
Miyaura M; Yoshida A; Sakurai A; Fujita M; Koyama AH; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.
Abstract: The mature Gag proteins of human immunodeficiency virus type 1 (HIV-1) are major components of infectious virions, and thought to carry out numerous functions throughout the HIV-1 replication cycle. We have recently generated numerous gag gene mutants of HIV-1 to genetically study the functions of the Gag proteins. Through the biological and biochemical analyses, our HIV-1 gag mutants have been grouped into early (defective for uncoating/reverse transcription), late (defective for virion release/maturation), and early/late (defective for both steps) mutants. Many mutants are found to efficiently inhibit the replication of wild-type virus. Worthy of note, there are some early mutants which show host cell-dependent replication potential.
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