CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene.

Clin Exp Immunol. 2000 Aug;121(2):210-5. Unique Identifier : AIDSLINE MED/20389922
Boesen M; Svane IM; Engel AM; Rygaard J; Thomsen AR; Werdelin O; Institute for Medical Microbiology and Immunology, Panum; Institute, University of Copenhagen, Copenhagen, Denmark.

Abstract: An attempt was made to identify the selection pressures put upon a growing tumour by CD8+ T cells. To this end tumours induced with 3-methylcholanthrene in T cell-deficient nude mice and in congenic T cell-competent nu/+ mice were transplanted to nu/+ recipients. The rejection rate of the sarcomas from nude mice was almost twice that of the sarcomas from nu/+ mice. Depletion of CD8+ T cells from nu/+ recipients prior to transplantation made them accept nude tumours that were consistently rejected by untreated nu/+ recipients. These findings suggest that a methylcholanthrene sarcoma during its growth in a T cell-competent host adapts to the T cell system through a selective elimination of highly immunogenic tumour cells that are susceptible to CD8+ T cell-mediated lysis.

Keywords: JOURNAL ARTICLE Animal CD8-Positive T-Lymphocytes/*IMMUNOLOGY Carcinogens Female Fibrosarcoma/CHEMICALLY INDUCED/*IMMUNOLOGY Graft Rejection/*IMMUNOLOGY Heterozygote Immunologic Surveillance Methylcholanthrene Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation/*IMMUNOLOGY Sarcoma, Experimental/CHEMICALLY INDUCED/*IMMUNOLOGY Support, Non-U.S. Gov't

KWDjournalarticleanimalcd8-positivet-lymphocytes/KWDimmunologycarcinogensfemalefibrosarcoma/chemicallyinduced/KWDimmunologygraftrejection/KWDimmunologyheterozygoteimmunologicsurveillancemethylcholanthrenemicemice,inbredbalbcmice,nudeneoplasmtransplantation/KWDimmunologysarcoma,experimental/chemicallyinduced/KWDimmunologysupport,non-uKWDsKWDgov't
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