Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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Rev Med Virol. 2000 Jul-Aug;10(4):231-53. Unique Identifier : AIDSLINE MED/20351800
Pillay D; Taylor S; Richman DD; PHLS Antiviral Susceptibility Reference Unit, Division of; Immunity and Infection, University of Birmingham, Medical School,; UK.
Abstract: More than 15 antiretroviral drugs are now available for clinical use, and have led to significant reductions in morbidity and mortality for HIV infected individuals. Nevertheless, antiviral drug resistance emerges to all these drugs, which limits their benefit. This review addresses the biological basis of antiretroviral drug resistance, and the prevalence of specific drug resistance associated mutations in patients treated with the three currently available classes of agents, namely nucleoside analogue reverse transcriptase inhibitors, non nucleoside reverse transcriptase inhibitors and protease inhibitors. In addition, data on prevalence of HIV drug resistance in untreated individuals published to date are summarised, and the implications of potential transmission of drug resistant HIV is discussed. Copyright 2000 John Wiley & Sons, Ltd.
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