Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.
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MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:34-9. Unique Identifier : AIDSLINE MED/20321529
Manegold C; Bernhard-Nocht-Institut fur Tropenmedizin, Klinische Abteilung,; Hamburg. manegold@bni.uni-hamburg.de
Abstract: While the effectiveness of conventional antiviral treatment is well proven, its limitations are becoming more and more evident. New approaches are resulting from the "decoding" of the pathogenesis of HIV infection. Thus, for example, experimental studies are looking at drug-induced blockade of the co-receptors necessary for the infection of the target cells. Treatment can be applied at all stages of viral replication. So far, reverse transcriptase and protease inhibitors have been employed. Other strategies are aimed at immunostimulation (e.g. with interleukin 2) and immunosuppression (cortisone, hydroxyurea). The development of therapeutic vaccines is difficult, but prophylactic vaccines hold out greater promise; field trials are underway.
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