Iodine absorption after intraoperative bowel irrigation with povidone-iodine. NLM AIDSLINE Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

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Iodine absorption after intraoperative bowel irrigation with povidone-iodine.

Dis Colon Rectum. 2000 Aug;43(8):1127-32. Unique Identifier : AIDSLINE MED/20404945
Tsunoda A; Shibusawa M; Kamiyama G; Takata M; Choh H; Kusano M; Second Department of Surgery, School of Medicine, Showa; University, Tokyo, Japan.

Abstract: PURPOSE: Povidone-iodine is a commonly used intrarectal tumoricidal agent in patients undergoing colorectal surgery. The aim of this study was to assess systemic absorption of total iodine and its effect on thyroid function after intrarectal application. METHODS: Twenty patients with carcinoma of the rectum received intraoperative irrigation with either povidone-iodine (Group A; n = 10) or physiologic saline (Group B; n = 10). Ten patients with carcinoma of the sigmoid colon (group C) were treated the same as Group A. Electrolyte, total iodine, triiodothyronine, thyroxine, and thyroid-stimulating hormone values were measured in serum preoperatively and before intraoperative irrigation and immediately, ten minutes, 1 hour, 6 hours, 24 hours, and two weeks after irrigation. RESULTS: No significant changes occurred in serum electrolytes. A significant uptake of the total iodine was demonstrated in each group. Total iodine levels examined immediately, ten minutes, and one hour after irrigation in Group C were significantly higher than those examined in Group B. Maximum values were obtained one hour after irrigation in Groups A and B and six hours after irrigation in Group C. No significant changes occurred in triiodothyronine, thyroxine, and thyroid-stimulating hormone levels among the three groups. The decrease in triiodothyronine levels after surgery was demonstrated in each group. We noted a decrease after surgery in thyroxine levels for Groups A and B and in thyroid-stimulating hormone levels for Group B. Those hormones were not affected by the administration of povidone-iodine. CONCLUSION: High serum levels of iodine did not cause organ toxicity, suggesting that a single use of intraoperative bowel irrigation with povidone-iodine may be performed with practically negligible risk.
Keywords: CLINICAL TRIAL JOURNAL ARTICLE Adult Aged Aged, 80 and over Female Human Intraoperative Care Iodine/*PHARMACOKINETICS Irrigation Male Middle Age Pharmaceutic Aids/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/ *PHARMACOKINETICS Povidone/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/ *PHARMACOKINETICS Rectal Neoplasms/*SURGERY Support, Non-U.S. Gov't Thyroid Function Tests Thyroid Gland/DRUG EFFECTS/*PHYSIOLOGY

KWDclinicaltrialjournalarticleadultagedaged,80andoverfemalehumanintraoperativecareiodine/KWDpharmacokineticsirrigationmalemiddleagepharmaceuticaids/administration&dosage/adverseeffects/KWDpharmacokineticspovidone/administration&dosage/adverseeffects/KWDpharmacokineticsrectalneoplasms/KWDsurgerysupport,non-uKWDsKWDgov'tthyroidfunctionteststhyroidgland/drugeffects/KWDphysiology
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