2000

Immunopathological factors for vertical transmission of HIV-1.: Pathobiology. 2000 Mar-Apr;68(2):53-67. Unique Identifier : AIDSLINE MED/20340758; Edgeworth RL; Ugen KE; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa, FL 33612, USA.; With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevi
Department of Pediatric Hematology-Oncology in Crete.: Pediatr Hematol Oncol. 1996 Sep-Oct;13(5):397-9. Unique Identifier : AIDSLINE MED/20356014; Kalmanti M; Department of Pediatric Hematology/Oncology, University Hospital; of Heraklion, University of Crete Medical School, Greece.
Immune response of immunocompromised children with malignancies to a recombinant hepatitis B vaccine.: Pediatr Hematol Oncol. 1996 Sep-Oct;13(5):425-31. Unique Identifier : AIDSLINE MED/20356018; Polychronopoulou-Androulakaki S; Panagiotou JP; Kostaridou S; Kyratzopoulou A; Haidas S; Department of Paediatric Haematology/Oncology, Aghia Sophia; Children's Hospital, Athens, Greece.; The aim of this study was to interpret the antibody response to hepatitis B vaccination following an intensified four-dose schedule in 140 cancer patients who presented at our clinic between January 1, 1993 and December 31, 1994. According to therapy status, the patients were divided into two groups: group A consisted
The prevalence of human T-cell lymphotropic virus type I infection in patients with cutaneous malignancies [letter]: Br J Dermatol. 2000 Jun;142(6):1237. Unique Identifier : AIDSLINE MED/20307339; Kawabata H; Setoyama M; Hanada S; Uozumi K; Kanekura T; Kanzaki T
Papulonecrotic tuberculide in a human immunodeficiency virus type 1-seropositive patient [letter]: Br J Dermatol. 2000 Jul;143(1):232-3. Unique Identifier : AIDSLINE MED/20344586; Alsina M; Campo P; Toll A; Martinez E; Palou J; Herrero C
The role of lymphocytes in human dermal wound healing.: Br J Dermatol. 2000 Jul;143(1):59-65. Unique Identifier : AIDSLINE MED/20344533; Boyce DE; Jones WD; Ruge F; Harding KG; Moore K; West Midlands Regional Plastic, Cardiff, UK.; BACKGROUND: Animal experimental data indicate a requirement for functionally active T lymphocytes to allow optimal healing of dermal wounds. Little evidence exists to confirm that this is the case in humans. Lymphocyte involvement in regulation of healing is probably mediated by release of secreted cytokines/growth fa
Optimal blood donation screening annotation.: Br J Haematol. 2000 Jun;109(4):694-8. Unique Identifier : AIDSLINE MED/20387578; Seifried E; Roth WK; Institute of Transfusion Medicine and Immune Haematology, Blood; Donor Service Hessia, Frankfurt, Germany.
[Non-occupational postexposure prophylaxis to human immunodeficiency virus: a two sided sword? (editorial)]: Enferm Infecc Microbiol Clin. 2000 Mar;18(3):105-7. Unique Identifier : AIDSLINE MED/20362683; Pena JM; Arribas J
[Mycobacterium kansasii osteomyelitis in a patient infected by the human immunodeficiency virus (letter)]: Enferm Infecc Microbiol Clin. 2000 Mar;18(3):148-9. Unique Identifier : AIDSLINE MED/20362697; Martinez T; Creagh R; Saavedra JM; Merino D
[Amplicor HIV-1 monitor and NucliSens HIV-1 QT: comparison of two new techniques to determine the viral load of the human immunodeficiency virus type 1 (letter)]: Enferm Infecc Microbiol Clin. 2000 Mar;18(3):149-50. Unique Identifier : AIDSLINE MED/20362698; Martin-Montero MC; Dominguez-Perez JR; Garcia-Bermejo I
Antimicrobial and radical modulation activity of AV-07, a poly-herbal formula.: In Vivo. 2000 Mar-Apr;14(2):351-5. Unique Identifier : AIDSLINE MED/20295916; Satoh K; Sakagami H; Ida Y; Komatsu N; Fujimaki M; Nakashima H; Kanbara K; Gupta M; Sarma DN; Mitra SK; Analysis Center, School of Pharmaceutical Sciences, Showa; University, Shinagawa-ku, Japan.; An extract of AV-07 was investigated for various biological activities. Pretreatment of mice with the AV-07 extract significantly protected them from lethal infection with E. coli. ESR spectroscopy showed that the extract produced radicals under alkaline conditions and enhanced the radical intensity of sodium ascorbat
Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes.: Microsc Res Tech. 2000 Aug 1;50(3):229-35. Unique Identifier : AIDSLINE MED/20351320; Raza A; Rush Cancer Institute, Rush-Presbyterian-St. Luke's Medical; Center, Chicago, Illinois 60612-3515, USA.araza@rush.edu; An attempt has been made in this article to summarize the state-of-the-art clinical experience with the use of anti-TNF therapies in four diseased states with special emphasis on myelodysplastic syndromes. Given the central role of TNF-alpha in initiating and perpetuating the chronic damage produced in the diseased or
Effect of intercistronic length on internal ribosome entry site (IRES) efficiency in bicistronic mRNA.: Gene Expr. 1999;8(5-6):299-309. Unique Identifier : AIDSLINE MED/20401903; Attal J; Theron MC; Puissant C; Houdebine LM; Unite de Differenciation Cellulaire, Institut National de la; Recherche Agronomique, Jouy en Josas, France.; Specific structures found in the mRNA of picornavirus are known to allow a cap-independent translation. These structures, named internal ribosome entry sites (IRES), are also able to favor translation of the second cistron in bicistronic mRNAs. Their mechanism of action is not well understood. In the present study, tw
Ten-year survival analysis of a cohort of heroin addicts in Catalonia: the EMETYST project.: Addiction. 2000 Jun;95(6):941-8. Unique Identifier : AIDSLINE MED/20402904; Sanchez-Carbonell X; Seus L; Blanquerna Faculty of Psychology and Educational Sciences, Ramon; Llull University, Barcelona, Spain. xaviersc@blanquerna.url.es; AIMS: To determine mortality rates and immediate causes of death in a cohort of heroin addicts, and to compare them with other European samples. DESIGN: Longitudinal follow-up study of a cohort for 10.5 years (March/July 1985-December 1995). SETTING: Catalonia, Spain . PARTICIPANTS:
Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant.: Braz J Med Biol Res. 2000 Jul;33(7):779-89. Unique Identifier : AIDSLINE MED/20340943; Muccioli C; Belfort R Jr; Departamento de Oftalmologia, Escola Paulista de Medicina,; Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.; eyebr@webmail.epm.br; The objective of this prospective study was to evaluate the efficacy and complications of the use of an intraocular sustained-release ganciclovir implant for the treatment of active cytomegalovirus ( CMV ) retinitis in AIDS pat
Molecular breeding of viruses [see comments]: Nat Genet. 2000 Aug;25(4):436-9. Unique Identifier : AIDSLINE MED/20392398; Soong NW; Nomura L; Pekrun K; Reed M; Sheppard L; Dawes G; Stemmer WP; Maxygen Inc., Redwood City, California, USA.; naywei_soong@maxygen.com; Genetic recombination is a major force driving the evolution of many viruses. Recombination between two copackaged retroviral genomes may occur at rates as high as 40% per replication cycle. This enables genetic information to be shuffled rapidly, leading to recombinants with new patterns of mutations and phenotypes.
Hospital response to DRG refinements: the impact of multiple reimbursement incentives on inpatient length of stay.: Health Econ. 2000 Jun;9(4):277-94. Unique Identifier : AIDSLINE MED/20320710; Gilman BH; Health Economics Research, Inc., Waltham, MA 02452, USA.; bgilman@her-cher.org; Recent research has warned that the introduction of Diagnosis Related Groups (DRGs) based on hospital treatment decisions will lead to an increase in the rate of marginal procedures and to a resumption of high medical expenditure growth rates. This paper explores the often contradictory effects of the multiple reimbur
Missed opportunities in Durban [editorial]: Nat Med. 2000 Aug;6(8):839. Unique Identifier : AIDSLINE MED/20392550
South African government continues policy of inactivity [news]: Nat Med. 2000 Aug;6(8):843. Unique Identifier : AIDSLINE MED/20392553; Birmingham K
HIV vaccine trials planned for Africa [news]: Nat Med. 2000 Aug;6(8):844. Unique Identifier : AIDSLINE MED/20392554; Birmingham K
NIAID funds new groups to develop HIV vaccines [news]: Nat Med. 2000 Aug;6(8):844. Unique Identifier : AIDSLINE MED/20392555; Watanabe ME
Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment [see comments]: Nat Med. 2000 Aug;6(8):904-9. Unique Identifier : AIDSLINE MED/20392581; Schuchert MJ; Wright RD; Colson YL; Department of Surgery, University of Pittsburgh Medical Center; Health System, University of Pittsburgh, Pittsburgh, Pennsylvania; 15261, USA.; The facilitating cell is a rare CD8+ bone marrow subpopulation that can enhance allogeneic hematopoietic stem cell engraftment across complete major histocompatibility complex barriers without inducing acute graft-versus-host disease. Here we describe a CD3epsilon-associated complex on the facilitating cell surface th
Fetal immunization by a DNA vaccine delivered into the oral cavity.: Nat Med. 2000 Aug;6(8):929-32. Unique Identifier : AIDSLINE MED/20392586; Gerdts V; Babiuk LA; van Drunen Littel-van den Hurk; Griebel PJ; Veterinary Infectious Disease Organization, University of; Saskatchewan, S7N 5E3 Saskatoon, Canada.; Infectious diseases are the main cause of neonatal morbidity and mortality in humans. The World Health Organization estimated that in 1995 approximately 8 million infants died within the first year of life from infectious diseases, including 5 million during the first week of life. Som
tRNA determinants for transcription antitermination of the Bacillus subtilis tyrS gene.: RNA. 2000 Aug;6(8):1131-41. Unique Identifier : AIDSLINE MED/20397808; Grundy FJ; Collins JA; Rollins SM; Henkin TM; Department of Microbiology, The Ohio State University, Columbus; 43210, USA.; Transcriptional regulation of the T box family of aminoacyl-tRNA synthetase and amino acid biosynthesis genes in Gram-positive bacteria is mediated by a conserved transcription antitermination system, in which readthrough of a termination site in the leader region of the mRNA is directed by a specific interaction with
[Changes in HIV-related attitudes and knowledge of teenagers following the Aulasida intervention in 1996-1997]: Rev Esp Salud Publica. 2000 Mar-Apr;74(2):163-76. Unique Identifier : AIDSLINE MED/20375380; Fernandez Garcia C; Molina Quilis R; Ramirez Sampedro C; Perez Perez E; Castilla Catalan J; Marrodan Girones J; Alcover Gimenez S; Tomas Dolz S; Centro de Salud Publica de Alzira, Valencia.; carmen.fernandez@sanidad.m400.gva.es; BACKGROUND: Schools being the ideal setting for carrying out Health Education activities, the aim of this study was that of pinpointing and quantifying the changes in attitudes and knowledge on the part of teenagers enrolled in school in Algemesi (Valencia) following an educational intervention regarding HIV infection
[Knowledge of AIDS of the medical students from three Mexican universities]: Rev Esp Salud Publica. 2000 Mar-Apr;74(2):177-87. Unique Identifier : AIDSLINE MED/20375381; Jarillo Soto EC; Delgadillo Gutierrez HJ; Granados Cosme JA; Universidad Autonoma Metropolitana-Xochimilco, Mexico.; jsec6322@cueyatl.uam.mx; BACKGROUND: The Hegemonic Medical Model is discussed and is articulated with the postulates of the sociology of the professions. The information takes Aids as a specific topic, because it involves the aspects of recent scientific development, of clinical and epidemiological importance and due to the research which is
[Drugs, Poverty and HIV: results regarding a provincial needle exchange program in Point de Reperes, Quebec]: Can J Public Health. 2000 May-Jun;91(3):176-80. Unique Identifier : AIDSLINE MED/20382978; Belanger D; Noel L; Alary M; Parent R; Poulin C; Claessens C; Unite de recherche en sante publique, Centre de recherche du; Pavillon CHUL-CHUQ, Quebec. dbelanger@cspq.qc.ca; In this study (n = 200), the characteristics of IDUs participating in a provincial needle exchange program (NEP) for more than 2 years (> 2 years) were compared with those of IDUs having participated for less than 2 years ( 2 years were more often recipients of wel
Verbal working memory in HIV-seropositive drug users.: J Int Neuropsychol Soc. 2000 Jul;6(5):548-55. Unique Identifier : AIDSLINE MED/20387846; Farinpour R; Martin EM; Seidenberg M; Pitrak DL; Pursell KJ; Mullane KM; Novak RM; Harrow M; VA Chicago Health Care System-West Side Division, Chicago,; Illinois, USA.; Recent evidence suggests that HIV-seropositive drug users are impaired on tasks of visuospatial working memory compared with drug users seronegative for HIV. In the current study we evaluated the performance of 30 HIV-seropositive male drug users and 30 risk-matched seronegative controls on two measures of verbal work
Risk awareness of HIV/AIDS among commercial farm workers in Zimbabwe.: Cent Afr J Med. 1999 Dec;45(12):316-20. Unique Identifier : AIDSLINE MED/20397003; Siziya S; Rusakaniko S; Tshimanga M; Marufu T; Department of Community Medicine, School of Medicine, University; of Zimbabwe, Avondale, Harare.; OBJECTIVE: To determine levels of perceived risk of HIV infection and the determinants of these perceptions among commercial farm workers. DESIGN: Cross sectional. SETTING: Commercial farms in Manicaland, Mashonaland Central, Mashonaland West and Mashonaland East provinces of Zimbabw
[Pneumonia in HIV-infected patients: clinical observations]: Unique Identifier : AIDSLINE MED/20401249; Wnuk A; Leszczyszyn-Pynka M; Bander D; Boron-Kaczmarska A; Kliniki Chorob Zakaznych Pomorskiej Akademii Medycznej w; Szczecinie.; OBJECTIVES: To determine the occurrence of pneumonias in HIV-infected patients in our hospital during 1990-1999; to evaluate the clinical significance of pneumonias in HIV-seropositive patients; to estimate the ethiology of pulmonary infection. MATERIALS AND METHODS: One hundred and two HIV-infected patients, 17 (16.6
Decreasing risk of viral transfusion-transmitted diseases in Croatia.: Croat Med J. 2000 Jun;41(2):191-6. Unique Identifier : AIDSLINE MED/20313040; Grgicevic D; Balija M; Pirc-Tiljak D; Mihaljevic I; Gjenero-Margan I; Zupancic-Salek S; Macek P; Croatian Institute of Transfusion Medicine, Zagreb, Croatia.; damir.grgicevic@hztm.tel.hr; AIM: To assess the risk of viral transfusion-transmitted infections in Croatia . METHODS: The following parameters were analyzed: frequency of blood donations repeatedly reactive for HBsAg and anti-HCV (1993-1999); blood donations co
Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha.: Clin Cancer Res. 2000 May;6(5):1671-7. Unique Identifier : AIDSLINE MED/20273332; Reuben JM; Lee BN; Johnson H; Fritsche H; Kantarjian HM; Talpaz M; Department of Laboratory Medicine, The University of Texas M.D.; Anderson Cancer Center, Houston 77030, USA.; jreuben@mdanderson.org; Chronic myelogenous leukemia (CML) is a disorder of the hematopoietic stem cell that results in malignant expansion of myeloid cells with a cytogenetic abnormality, the translocation between chromosomes 9 and 22 known as the Philadelphia chromosome. Treatment with IFN-alpha has proven to be an effective therapy, induc
[Knowledge, attitudes, and practices of Brazilian women treated in the primary health care system concerning sexually transmitted diseases]: Cad Saude Publica. 2000;16(## Suppl 1):103-12. Unique Identifier : AIDSLINE MED/20366516; Fernandes AM; de Gaspari Antonio D; Bahamondes LG; Cupertino CV; Departamento de Tocoginecologia, Pontificia Universidade; Catolica de Campinas, Brasil.; An increase has been observed in the prevalence of HIV infection among Brazilian women in recent years. This study focused on women s knowledge, attitudes, and practices towards prevention of sexually transmitted diseases (STDs) in the primary health care system in Campinas, Sao Paulo. Of the 249 women interviewed, 10
[Risk behavior among Brazilian Military conscripts, 1998: an study of HIV infections following socioeconomic differences]: Cad Saude Publica. 2000;16(## Suppl 1):113-28. Unique Identifier : AIDSLINE MED/20366517; Szwarcwald CL; Castilho EA; Barbosa A Jr; Gomes MR; Costa EA; Maletta BV; de Carvalho RF; de Oliveira SR; Chequer P; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; A study of HIV-related risk behavior was carried out in 1998 among Brazilian military conscripts aged 17-20 years. A sample of 30,318 subjects was selected in three strata, pertaining to counties from: 1) the North and Central-West (N/CW); 2) South (S); and the states of Rio de Janeiro and Sao Paulo. HIV prevalence ra
[Estimated number of orphans due to maternal AIDS in Brazil, 1987-99]: Cad Saude Publica. 2000;16(## Suppl 1):129-34. Unique Identifier : AIDSLINE MED/20366518; Szwarcwald CL; Andrade CL; Castilho EA; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; This study proposes a procedure to estimate the number of orphans due to maternal AIDS. The procedure estimates the number of orphans by calendar year, multiplying the cumulative fertility rate by the number of AIDS deaths among women aged 15-49 years. Because the procedure refers to the number of children that are al
[Estimated number of HIV-infected individuals aged 15-49 years in Brazil, 1998]: Cad Saude Publica. 2000;16(## Suppl 1):135-41. Unique Identifier : AIDSLINE MED/20366519; Szwarcwald CL; Castilho EA; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; This study estimates the number of HIV-infected individuals from 15 to 49 years of age in Brazil in 1998 based on sentinel population studies in pregnant women, with a selection bias in the sample. A principal components procedure was used to group 44 counties in homogeneous 13 clu
[Temporal study in AIDS-associated disease in Brazil, 1980-1999]: Cad Saude Publica. 2000;16(## Suppl 1):21-36. Unique Identifier : AIDSLINE MED/20366510; Guimaraes MD; Departamento de Medicina Preventiva e Social, Faculdade de; Medicina, Universidade Federal de Minas Gerais, Belo Horizonte,; MG, 30130-100, Brasil.; Trends in annual incidence of reported AIDS-associated opportunistic infections (OI/100 adults > 12 years old) among AIDS cases were estimated at the national level in Brazil from 1980 through May 1999. The analysis included chi-square and linear regression modeling. The opportunis
[Dynamic models and social networks: a review and reflections on their contribution to understanding the HIV epidemic]: Cad Saude Publica. 2000;16(## Suppl 1):37-51. Unique Identifier : AIDSLINE MED/20366511; Barbosa MT; Byington MR; Struchiner CJ; Departamento de Matematica e Estatistica, Universidade do Rio; de Janeiro, Brasil.; Due to certain specificities in the HIV epidemic, its spread has escaped the random transmission pattern of other infectious diseases. Observation of the epidemic has shown that individual behavior - relational patterns among individuals - plays a crucial role in HIV transmission and that strategies to prevent the epi
[AIDS in Brazil: a changing epidemic (editorial)]: Cad Saude Publica. 2000;16(## Suppl 1):4-5. Unique Identifier : AIDSLINE MED/20366508; Castilho EA; Bastos FI; Scwarcwald CL; Fonseca MG; Coordenacao Nacional de DST e AIDS, Ministerio da Saude.
[Classification by occupation of AIDS cases in Brazil - 1995]: Cad Saude Publica. 2000;16(## Suppl 1):53-64. Unique Identifier : AIDSLINE MED/20366512; Cassano C; de Medeiros Frias LA; Valente JG; Departamento de Epidemiologia e Metodos Quantitativos de Saude,; Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio; de Janeiro, Brasil.; Based on occupational classification of AIDS cases reported in Brazil in 1995 and recorded in the Data Base for Reported Diseases (SINAN), AIDS incidence rates were estimated per 100 thousand inhabitants by occupation, according to the 1991 National Census. Nationwide rates for emp
[AIDS and pauperization: principal concepts and empirical evidence]: Cad Saude Publica. 2000;16(## Suppl 1):65-76. Unique Identifier : AIDSLINE MED/20366513; Bastos FI; Szwarcwald CL; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; This paper discusses methodologies for analyzing relations between social inequalities, marginalization, prejudice, and vulnerability to HIV/AIDS, highlighting current difficulties and alternative research strategies. It also reviews the international and Brazilian literature, emphasizing: economic and macropolitical
[The spread of the AIDS epidemic in Brazil from 1987 to 1996: a spatial analysis]: Cad Saude Publica. 2000;16(## Suppl 1):7-19. Unique Identifier : AIDSLINE MED/20366509; Szwarcwald CL; Bastos FI; Esteves MA; de Andrade CL; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; Mean AIDS incidence rates were calculated for three time periods, 1987-89, 1990-92, and 1993-96, using reported adult AIDS cases by county. The analysis included the following variables: population of counties for resident AIDS cases ; proportion of population residing in urban areas , and concentration of poverty
[AIDS and level of education in Brazil: temporal evolution from 1986 to 1996]: Cad Saude Publica. 2000;16(## Suppl 1):77-87. Unique Identifier : AIDSLINE MED/20366514; Fonseca MG; Bastos FI; Derrico M; Andrade CL; Travassos C; Szwarcwald CL; Coordenacao Nacional de DST e AIDS, Ministerio da Saude,; Brasilia, Brasil.; This article analyzes the temporal distribution of reported AIDS cases by level of education used as a proxy variable for individual socioeconomic status. All AIDS cases aged 20-69 years and reported through May 29, 1999, with date of diagnosis between 1986-1996, were included in the study. Incidence rates were calcul
[Poverty and HIV/AIDS: anthropological and sociological aspects]: Cad Saude Publica. 2000;16(## Suppl 1):89-102. Unique Identifier : AIDSLINE MED/20366515; Parker R; Camargo KR Jr; Instituto de Medicina Social, Universidade do Estado do Rio de; Janeiro, Rio de Janeiro, Brasil.; Focusing on the HIV/AIDS epidemic as a summation of several epidemics coexisting in the same space and drawing on Brazilian epidemiological data, we argue that the epidemic there shows variations already described elsewhere, such as feminization, pauperization, juvenization and interiorization, as a result of the deep
Mutational analysis of HIV-1 gag proteins (review).: Int J Mol Med. 2000 Sep;6(3):265-9. Unique Identifier : AIDSLINE MED/20394235; Miyaura M; Yoshida A; Sakurai A; Fujita M; Koyama AH; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.; The mature Gag proteins of human immunodeficiency virus type 1 (HIV-1) are major components of infectious virions, and thought to carry out numerous functions throughout the HIV-1 replication cycle. We have recently generated numerous gag gene mutants of HIV-1 to genetically study the functions of the Gag proteins. Th
Soluble CD30 is more relevant to disease activity of atopic dermatitis than soluble CD26.: Clin Exp Immunol. 2000 Aug;121(2):187-92. Unique Identifier : AIDSLINE MED/20389919; Katoh N; Hirano S; Suehiro M; Ikenaga K; Yamashita T; Sugawara N; Yasuno H; Department of Dermatology, Kyoto Prefectural University of; Medicine, Kyoto, and Mitsubishi Kagaku Bio-Clinical Laboratories,; Inc., Tokyo, Japan. nkatoh@derm.kpu-m.ac.jp; It is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible co
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens.: Clin Exp Immunol. 2000 Aug;121(2):193-200. Unique Identifier : AIDSLINE MED/20389920; Ryan EJ; Nilsson L; Kjellman N; Gothefors L; Mills KH; Infection and Immunity Group, National University of Ireland,; Maynooth, Ireland.; Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also contributes to protection against Bordetella pertussis, and it has already been demonstrated that Pa in
CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene.: Clin Exp Immunol. 2000 Aug;121(2):210-5. Unique Identifier : AIDSLINE MED/20389922; Boesen M; Svane IM; Engel AM; Rygaard J; Thomsen AR; Werdelin O; Institute for Medical Microbiology and Immunology, Panum; Institute, University of Copenhagen, Copenhagen, Denmark.; An attempt was made to identify the selection pressures put upon a growing tumour by CD8+ T cells. To this end tumours induced with 3-methylcholanthrene in T cell-deficient nude mice and in congenic T cell-competent nu/+ mice were transplanted to nu/+ recipients. The rejection rate of the sarcomas from nude mice was a
Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7.: Clin Exp Immunol. 2000 Aug;121(2):216-25. Unique Identifier : AIDSLINE MED/20389923; Chu NR; Wu HB; Wu T; Boux LJ; Siegel MI; Mizzen LA; StressGen Biotechnologies Corporation, Victoria, B.C., Canada,; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, MD, USA. rchu@stressgen.com; Human papillomavirus type 16 (HPV16) infection has been linked to the development of cervical and anal dysplasia and cancer. One hallmark of persistent infection is the synthesis of the viral E7 protein in cervical epithelial cells. The expression of E7 in dysplastic and transformed cells and its recognition by the im
Characterization of T cell clones derived from lymph nodes and lungs of Pseudomonas aeruginosa-susceptible and resistant mice following immunization with heat-killed bacteria.: Clin Exp Immunol. 2000 Aug;121(2):275-82. Unique Identifier : AIDSLINE MED/20389931; Kondratieva TK; Kobets NV; Khaidukov SV; Yeremeev VV; Lyadova IV; Apt AS; Tam MF; Stevenson MM; Experimental Immunogenetics Laboratory, Central Institute for; Tuberculous and Laboratory for Immunochemistry, Shemyakin and; Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Pseudomonas aeruginosa-resistant BALB/c and susceptible C57Bl/6 (B6) mice were immunized with heat-killed Pseudomonas either in the foot pad or via the trachea, and panels of Pseudomonas-specific T cell clones were developed from lymph nodes and lungs. All clones from either strain, whether of lymph node or lung origi
Differential effect of cholera toxin on CD45RA+ and CD45RO+ T cells: specific inhibition of cytokine production but not proliferation of human naive T cells.: Clin Exp Immunol. 2000 Aug;121(2):283-8. Unique Identifier : AIDSLINE MED/20389932; Eriksson K; Nordstrom I; Czerkinsky C; Holmgren J; Department of Medical Microbiology and Immunology, Goteborg; University, Goteborg, Sweden and INSERM 4 U 364, Nice, France.; kristina.eriksson@microbio.gu.se; We have studied how cholera toxin (CT) and its non-toxic cell-binding B-subunit (CTB) affect the activation of pure human T cells in an anti-CD3-driven system. CT, as opposed to CTB, strongly suppressed the proliferative responses as well as cytokine production in CD4+ and CD8+ T cells. CT however, had a differential
Dysregulation in IL-12 secretion by neutrophils from HIV-infected patients.: Clin Exp Immunol. 2000 Aug;121(2):311-9. Unique Identifier : AIDSLINE MED/20389936; Vecchiarelli A; Monari C; Palazzetti B; Bistoni F; Casadevall A; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, Perugia, Italy.; vecchiar@unipg.it; It is generally believed that neutrophils from HIV-infected patients are functionally competent, but several studies have shown impairment in neutrophil fungal killing and cytokine production. In this study we evaluated the ability of neutrophils from healthy donors and HIV-infected patients to produce IL-12 in respon
High levels of IL-10 and determination of other cytokines and chemokines in HIV-associated haemophagocytic syndrome.: Clin Exp Immunol. 2000 Aug;121(2):320-3. Unique Identifier : AIDSLINE MED/20389937; Benveniste O; Dereuddre-Bosquet N; Clayette P; Leport C; Vilde JL; Dormont D; CEA, Service de Neurovirologie, CRSSA, DRM/DSV, Institut; Paris-Sud sur les Cytokines, B.P. 6, Fontenay aux Roses Cedex,; France. olivier.benveniste@psl.ap-hop-paris.fr; Haemophagocytic syndrome (HPS) and HIV infection are both associated with cytokine network dysregulation. We therefore analysed plasma levels and mRNA synthesis in peripheral blood mononuclear cells (PBMC) of cytokines, chemokines and chemokine receptors in one HIV-infected patient with HPS. We compared the results wi
Expression of MHC class II in T cells is associated with increased HIV-1 expression.: Clin Exp Immunol. 2000 Aug;121(2):324-31. Unique Identifier : AIDSLINE MED/20389938; Saifuddin M; Spear GT; Chang C; Roebuck KA; Department of Immunology/Microbiology, Rush University, Chicago,; IL, USA. msaifudd@rush.edu; HIV-1 replicates in activated T cells at significantly higher levels than in resting cells. Thus, certain molecules up-regulated during T cell activation appear to be important for HIV-1 replication. In this study, we present evidence suggesting that expression of MHC class II (class II) molecules on CD4+ T cells faci
Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry.: Clin Exp Immunol. 2000 Aug;121(2):332-8. Unique Identifier : AIDSLINE MED/20389939; Bendelja K; Gagro A; Bace A; Lokar-Kolbas R; Krsulovic-Hresic V; Drazenovic V; Mlinaric-Galinovic G; Rabatic S; Department of Cellular Immunology, Institute of Immunology,; University Hospital for Infectious Diseases, University; Children's Hospital, Division of Virology, Croatian National; Institute of Public Health, Zagrab, Croatia.; Acute RSV infection in infancy may produce some asthma-like symptoms and may be followed by a recurrent wheeze later in childhood. It has been proposed that RSV infection stimulates type-2 cytokine responses, resembling those found in atopy and asthma. Peripheral blood cells were obtained from RSV-infected infants (n
Absence of CD40-CD40 ligand interactions in X-linked hyper-IgM syndrome does not affect differentiation of T helper cell subsets.: Clin Exp Immunol. 2000 Aug;121(2):346-52. Unique Identifier : AIDSLINE MED/20389941; Uronen H; Callard RE; Immunobiology Unit, Institute of Child Health, University College; London, London, UK.; The aim of this study was to investigate the effect of absent CD40-CD40 ligand interactions in patients with X-linked hyper-IgM syndrome (XHIGM) on the generation of Th1 and Th2 immunity. Whole blood from patients and sex- and age-matched controls was stimulated with phorbol myristate acetate (PMA) and calcium ionopho
Structure and self-association of the Rous sarcoma virus capsid protein.: Structure Fold Des. 2000 Jun 15;8(6):617-28. Unique Identifier : AIDSLINE PDB/1EOQ; Kingston RL; Fitzon-Ostendorp T; Eisenmesser EZ; Schatz GW; Vogt VM; Post CB; Rossmann MG; Department of Biological Sciences, Purdue University, West; Lafayette, IN 47907, USA.; BACKGROUND: The capsid protein (CA) of retroviruses, such as Rous sarcoma virus (RSV), consists of two independently folded domains. CA functions as part of a polyprotein during particle assembly and budding and, in addition, forms a shell encapsidating the genomic RNA in the mature, infectious virus. RESULTS: The str
Science before the CD-ROM [editorial; comment]: Rev Med Virol. 2000 Jul-Aug;10(4):205-6. Unique Identifier : AIDSLINE MED/20351797; Griffiths PD
Experimental infection of monkeys with Langat virus II. Turnover of circulating virus, 1967 [classical article] [see comments]: Rev Med Virol. 2000 Jul-Aug;10(4):207-15. Unique Identifier : AIDSLINE MED/20351798; Nathanson N; Harrington B
Clinical uses of non-nucleoside reverse transcriptase inhibitors.: Rev Med Virol. 2000 Jul-Aug;10(4):217-29. Unique Identifier : AIDSLINE MED/20351799; Harris M; Montaner JS; AIDS Research Program, St. Paul's Hospital, Vancouver, B.C.,; Canada.; Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are currently available for treatment of HIV-1 as part of combination antiretroviral therapy. Oral dosing is administered three times daily for delavirdine (DLV), twice daily for
Incidence and impact of resistance against approved antiretroviral drugs.: Rev Med Virol. 2000 Jul-Aug;10(4):231-53. Unique Identifier : AIDSLINE MED/20351800; Pillay D; Taylor S; Richman DD; PHLS Antiviral Susceptibility Reference Unit, Division of; Immunity and Infection, University of Birmingham, Medical School,; UK.; More than 15 antiretroviral drugs are now available for clinical use, and have led to significant reductions in morbidity and mortality for HIV infected individuals. Nevertheless, antiviral drug resistance emerges to all these drugs, which limits their benefit. This review addresses the biological basis of antiretrovi
Novel compounds in preclinical/early clinical development for the treatment of HIV infections.: Rev Med Virol. 2000 Jul-Aug;10(4):255-77. Unique Identifier : AIDSLINE MED/20351801; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections, belong to one of the following classes: (i) nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), (ii) non-nucleoside reverse transcriptase inhibitors (NNRTIs) and (iii)
[Increased girth, thin arms. Unusual changes in HIV therapy (news)]: MMW Fortschr Med. 1999 Sep 9;141(36):62-3. Unique Identifier : AIDSLINE MED/20362232
[The right to expensive drugs. What is indicated cannot have economic limitations (interview)]: MMW Fortschr Med. 2000 Apr 27;142(17):43-4. Unique Identifier : AIDSLINE MED/20337187; Wimmer R
[Antiretroviral therapy. NNRTI (non-nucleoside reverse transcriptase inhibitor)]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:14-6. Unique Identifier : AIDSLINE MED/20321525
[Protease inhibitor saving alternatives]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:16-7. Unique Identifier : AIDSLINE MED/20321526
[Antiretroviral therapy. A brief profile of all available drugs]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:18-29. Unique Identifier : AIDSLINE MED/20321527; Jablonowski H; Stadtisches Klinikum Salzgitter, Medizinische Klinik.
[Non-nucleoside reverse transcriptase inhibitor as a fully viable alternative. Strong therapy start without protease inhibitor]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:30-3. Unique Identifier : AIDSLINE MED/20321528
[Pathogenesis of HIV infection as the key to eradication? New therapeutic approaches]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:34-9. Unique Identifier : AIDSLINE MED/20321529; Manegold C; Bernhard-Nocht-Institut fur Tropenmedizin, Klinische Abteilung,; Hamburg. manegold@bni.uni-hamburg.de; While the effectiveness of conventional antiviral treatment is well proven, its limitations are becoming more and more evident. New approaches are resulting from the decoding of the pathogenesis of HIV infection. Thus, for example, experimental studies are looking at drug-induced blockade of the co-receptors necessa
[Various triple therapies in direct comparison. New decision aids for initial therapy]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:40-2. Unique Identifier : AIDSLINE MED/20321530
[Nucleoside reverse transcriptase inhibitors. Sex-specific effectiveness and tolerance]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:42-3. Unique Identifier : AIDSLINE MED/20321531
[Public health economic aspects of antiretroviral therapy. Can we afford to do less?]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:45-9. Unique Identifier : AIDSLINE MED/20321532; Stoll M; Claes C; Schulte E; Korner T; von der Schulenburg JM; Schmidt R; Abteilung Klinische Immunologie, Medizinischen Hochschule; Hannover. Stoll.Matthias@Mh-Hannover.de; In Germany , politically motivated economic considerations are becoming even more important. In this connection, scientific research into the health system is not limited merely to a consideration of costs, but utilizes the same methods and conceptual models as economic research in
[Antiretroviral therapy. Update at the beginning of a new century]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:5-13. Unique Identifier : AIDSLINE MED/20321524; Jablonowski H; Med. Klinik am Stadt. Krankenhaus Salzgitter.; For antiretroviral therapy (ART) nucleoside reverse transcriptase inhibitors (NRTI), protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) are available, and are used in combination treatments. The use of PI is associated with new side
[New variations in highly active antiretroviral therapy. Simple combination as a promising option]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:50-2. Unique Identifier : AIDSLINE MED/20321533
[Second chance therapy. New protease inhibitor for salvage therapy]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:53. Unique Identifier : AIDSLINE MED/20321534
[HIV infection in childhood]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:54-7. Unique Identifier : AIDSLINE MED/20321535; Seel K; Grosch-Worner I; Universitatsklinikum, Humboldt-Universitat zu Berlin.; karen.seel@charite.de; As a result of preventive measures during pregnancy and improved antiretroviral combination treatment, the problem area of HIV infection in childhood has undergone a change in recent years. Thanks to intensive cooperation between obstetricians and pediatricians, mother-to-child transmission of HIV in
[HIV plus hepatitis C or Kaposi sarcoma. Treatment options in coinfection]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:58-9. Unique Identifier : AIDSLINE MED/20321536
[Chronic hepatitis C in HIV-infected patients. Unfavorable interaction of HIV and HCV infection]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:60-2. Unique Identifier : AIDSLINE MED/20321537; Mauss S; HIV coinfection promotes the progression of chronic hepatitis C. The increased hepatic mortality and improved life expectancy of HIV-positive patients warrants treatment of chronic hepatitis C in those infected with HIV. The treatment of hepatitis C considered standard for HIV-negative and, in principle, also for HIV-
[Osteonecrosis: a rare complication of HIV infection. Association with certain risk factors]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:64-7. Unique Identifier : AIDSLINE MED/20321538; Meyer D; Behrens G; Stoll M; Schmidt RE; Abteilung Klinische Immunologie, Medizinischen Hochschule; Hannover.; Osteonecrosis is a rare complication of HIV infection. The presumptive cause of the aseptic osteonecrosis is a disturbed blood supply to the bone. Most cases of osteonecrosis are associated with numerous risk factors, such as use of steroids, alcohol abuse, coagulopathies or metabolic derangements. Since conventional
[Lipodystrophy and metabolic disorders in anti-HIV therapy]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:68-71. Unique Identifier : AIDSLINE MED/20321539; Behrens GM; Stoll M; Schmidt RE; Abteilung fur Klinische Immunologie, Medizinische Hochschule; Hannover. Behrens.Georg@MH-Hannover.de; For the effective treatment of HIV infection, combinations of antiretroviral drugs that, at various points of attack, prevent viral replication are used. After the introduction of HIV-1 specific protease inhibitors , various metabolic complications and changes in bod
[The future of HIV therapy. Research pipelines are filled with options]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:72-9. Unique Identifier : AIDSLINE MED/20321540; Jablonowski H; Medizinische Klinik am Stadt. Krankenhaus Salzgitter.; Following the first international conference in 1999, twice as many new antiretroviral substances are in the early clinical or preclinical phase of investigation as are currently approved for ART in Germany . These data are almost certainly not complete, and the number of candidat
[Campaign against a chameleon. Therapeutic strategies to control a survival artist]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:80-1. Unique Identifier : AIDSLINE MED/20321541
[Observing CD4 cell count and viral load alone is not enough. Value of protease inhibitors]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:81-2. Unique Identifier : AIDSLINE MED/20321542
[Therapy planning. It depends on the proper administration series]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:82-5. Unique Identifier : AIDSLINE MED/20321543
[Therapy of advanced stages. "Mega-HAART" or "drug holiday"?]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:86-7. Unique Identifier : AIDSLINE MED/20321544
Good worms or bad worms: do worm infections affect the epidemiological patterns of other diseases? [see comments]: Parasitol Today. 2000 Jul;16(7):273-4. Unique Identifier : AIDSLINE MED/20317281; Bundy D; Sher A; Michael E; World Bank, 1818 H Street NW, Washington DC 20433, USA.; dbundy@worldbank.org
Good worms or bad worms: do worm infections affect the epidemiological patterns of other diseases? [letter; comment]: Parasitol Today. 2000 Jul;16(7):312. Unique Identifier : AIDSLINE MED/20317290; Bentwich Z
Justice and access to therapies for AIDS.: AIDS Public Policy J. 1999 Spring;14(1):20-5. Unique Identifier : AIDSLINE MED/20370100; Eckenwiler L; Department of Philosophy, Old Dominion University, Norfolk,; Virginia, USA.
Morals, methods, and neutrality in human-subject research.: AIDS Public Policy J. 1999 Spring;14(1):26-9. Unique Identifier : AIDSLINE MED/20370101; Herrera CD; Department of Philosophy and Religion, Montclair State; University, Upper Montclair, New Jersey, USA.
Organizational imperatives and policy perspectives of AIDS community-based organizations: a view from the states.: AIDS Public Policy J. 1999 Spring;14(1):3-19. Unique Identifier : AIDSLINE MED/20370099; Robins L; Backstrom C; Roosevelt University, Chicago, USA.
Toward a systematic understanding: a two-way relational model between drug use and HIV/AIDS.: AIDS Public Policy J. 1999 Spring;14(1):30-43. Unique Identifier : AIDSLINE MED/20370102; Shaw VN; Department of Sociology, California State University, Northridge,; USA.
Perspectives in conflict: the response to transfusion-associated AIDS.: AIDS Public Policy J. 1999 Summer;14(2):47-67. Unique Identifier : AIDSLINE MED/20370103; Corless IB; Stowell CP; Fulton R; Weeks OD; Massachusetts General Hospital Institute of Health Professions,; Boston, USA.
Examining medical coverage for Medicare beneficiaries with HIV/AIDS.: AIDS Public Policy J. 1999 Summer;14(2):68-79. Unique Identifier : AIDSLINE MED/20370104; Schietinger H; Schechter C; Domestic Health Services, Academy for Educational Development,; Washington, D.C., USA.
Military HIV-prevention education: the use of evaluation to inform the evolution of policy.: AIDS Public Policy J. 1999 Summer;14(2):80-91. Unique Identifier : AIDSLINE MED/20370105; Hendrix CW; Daniell FD; Johns Hopkins University School of Medicine, Baltimore, Maryland,; USA.
Human glomerular epithelial cell express CD4 and interaction with gp120 protein promotes PYK2 tyrosine phosphorylation.: Mol Cell Biol Res Commun. 1999 May;1(2):140-3. Unique Identifier : AIDSLINE MED/20391253; Kapasi AA; Franki N; Ding G; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York 11040, USA.; Focal segmental glomerulosclerosis (FSGS) is the predominant glomerular lesion in patients with HIV infection. Visceral glomerular epithelial cell (vGEC) injury is a key feature of this glomerular lesion. However, the exact mechanism of HIV-1-induced vGEC injury is not clear. We studied the presence of CD4 (HIV-1 rece
Management of the infant born to an HIV-1 infected mother.: Paediatr Drugs. 1999 Oct-Dec;1(4):325-30. Unique Identifier : AIDSLINE MED/20388473; Rongkavilit C; Mitchell CD; Nachman S; Division of Pediatric Infectious Diseases, University of Miami; School of Medicine, Florida, USA.
Pneumocystis carinii pneumonia in adolescents.: Paediatr Drugs. 2000 Mar-Apr;2(2):133-8. Unique Identifier : AIDSLINE MED/20391185; Rudy BJ; Rutstein RM; Nachman SA; Division of General Paediatrics, Children's Hospital of; Philadelphia, USA.
[Transmission of HBV, HCV and HIV by infectious medical personnel--presentation of an overview]: Chirurg. 2000 Apr;71(4):389-95. Unique Identifier : AIDSLINE MED/20299644; Hasselhorn HM; Hofmann F; Lehrstuhl fur Arbeitsphysiologie, Arbeitsmedizin und; Infektionsschutz, Bergische Universitat/Gesamthochschule,; Wuppertal. hans-martin.hasselhorn@arbmed.uni-wuppertal.de; This report analyzes 46 cases of personnel-to-patient transmissions of hepatitis B (HB), hepatitis C (HC) and HIV in health care settings. Similar circumstances were found for transmission of HB (40 cases, 404 infected patients), HC (4 cases, 224 infected patients) and HIV (2 cases, 7 infected patients). Cases with th
[European and North American regulations on employing HBV-, HCV- and HIV-infected persons in health care]: Chirurg. 2000 Apr;71(4):396-403. Unique Identifier : AIDSLINE MED/20299645; Hofmann F; Hasselhorn HM; Lehrstuhl fur Arbeitsphysiologie, Arbeitsmedizin und; Infektionsschutz, Bergische Universitat-Gesamthochschule; Wuppertal.; In the United States of America (1991), in Canada (1998), in the UK (1993, 1994) and in Germany (1999) recommendations have been published concerning performance of exposure-prone procedures (EPP) by persons i
A video densitometric analysis of viral burden and follicular dendritic cell damage in lymph nodes in the latency phase of HIV infection.: Unique Identifier : AIDSLINE MED/20341015 P; Zannini C; Favre A; Ciccone E; Plebani A; Duse M; Grossi CE; Pesce C
Flow cytometric analysis of the Vbeta repertoire in healthy controls.: Cytometry. 2000 Aug 1;40(4):336-45. Unique Identifier : AIDSLINE MED/20378902; van den Beemd R; Boor PP; van Lochem EG; Hop WC; Langerak AW; Wolvers-Tettero IL; Hooijkaas H; van Dongen JJ; Department of Immunology, Erasmus University Rotterdam/University; Hospital Rotterdam, The Netherlands.; BACKGROUND: Analysis of the T-cell receptor (TCR)-Vbeta repertoire has been used for studying selective T-cell responses in autoimmune disease, alloreactivity in transplantation, and protective immunity against microbial and tumor antigens. For the interpretation of these studies, we need information about the Vbeta r
Human amniotic membrane in the reconstruction of the ocular surface.: Doc Ophthalmol. 1999;98(3):273-83. Unique Identifier : AIDSLINE MED/20399544; Gabric N; Mravicic I; Dekaris I; Karaman Z; Mitrovic S; Lions Croatian Eye Bank, Department of Ophthalmology, Sveti Duh; General Hospital, Zagreb. lhob@yahoo.com; We sought to determine the efficacy of amniotic membrane transplantation (AMT) in the reconstruction of ocular surface. AMT was performed on 40 eyes with following indications: I, persistent corneal ulceration (n = 12); II, impending perforation (n = 6); III, persistent epithelial defect on the corneal graft (n = 6);
Hepatitis B and C virus infections and liver function in AIDS patients at Chris Hani Baragwanath Hospital, Johannesburg.: East Afr Med J. 2000 Jan;77(1):13-5. Unique Identifier : AIDSLINE MED/20401128; Lodenyo H; Schoub B; Ally R; Kairu S; Segal I; Centre for Clinical Research, Kenya Medical Research Institute,; South Africa.; BACKGROUND: Impaired liver function tests and co-infection with hepatitis viruses in AIDS patients are common in western countries. OBJECTIVE: To assess liver function and prevalence of co-infection with hepatitis B and hepatitis C viruses in AIDS patients at Chris Hani Baragwanath Hospital. DESIGN: A prospective stud
Factors affecting condom use among South African university students.: East Afr Med J. 2000 Jan;77(1):46-52. Unique Identifier : AIDSLINE MED/20401137; Peltzer K; Department of Psychology, University of the North, Sovenga, South; Africa.; OBJECTIVE: To investigate factors affecting condom use among South African university students. DESIGN: Cross-sectional survey. SETTING: Department of Psychology, University of the North, South Africa. PARTICIPANTS: One hundred and forty six female and sixty first year male psychology students, mean age 20.9 years (SD
Potential role of environmental factors in the etiology and pathogenesis of atopy: a working model.: Environ Health Perspect. 1999 Jun;107 Suppl 3:485-7. Unique Identifier : AIDSLINE MED/99353943; Holt PG; TVW Telethon Institute for Child Health Research, Perth, Western; Australia. patrick@ichr.uwa.edu.au; Sensitization to inhalant allergens commonly commences in utero, and most children are born with weak T helper-2 (Th2)-polarized T-cell immunity to these agents. During early life, these responses are normally deviated toward the Th1 cytokine profile. However, in atopics this immune deviation process fails, leading in
Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity.: Environ Health Perspect. 1999 Oct;107 Suppl 5:807-10. Unique Identifier : AIDSLINE MED/99434037; Bagenstose LM; Salgame P; Monestier M; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; Experimental models of chemically induced autoimmunity have contributed to our understanding of the development of autoimmune diseases in humans. Heavy metals such as mercury induce a dramatic activation of the immune system and autoantibody production in genetically susceptible rats and mice. This autoimmune syndrome
Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women.: Unique Identifier : AIDSLINE MED/20387168; Yang JH; Chen CD; Wu MY; Chao KH; Yang YS; Ho HN; OBJECTIVE: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). DESIGN: Prospective study. SETTING: University teaching hospital. PATIENT(S): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). INTERVENTION(S):
Characterization of expanded T cell clones in healthy macaques: ontogeny, distribution and stability.: Dev Comp Immunol. 2000 Sep-Oct;24(6-7):703-15. Unique Identifier : AIDSLINE MED/20293001; Nam KH; Illes Z; Terao K; Yoshikawa Y; Yamamura T; Tsukuba Primate Center, National Institute of Infectious; Diseases, Ibaraki, Japan.; Peripheral expanded T cell clones have been discussed mainly in relation to certain diseases or immune function in humans and mice. There is little information on their ontogeny, stability and distribution among T cell subsets as well as major lymphoid organs. We applied reverse transcription-polymerase chain reaction
Lentivirus vectors for gene therapy.: Biochem Soc Trans. 1999 Dec;27(6):841-7. Unique Identifier : AIDSLINE MED/20288923; Lever AM; Kaye JF; McCann E; Chadwick D; Dorman N; Thomas J; Zhao J; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, U.K.
All that scallops is not celiac disease.: Gastrointest Endosc. 2000 Jun;51(6):717-20. Unique Identifier : AIDSLINE MED/20300719; Shah VH; Rotterdam H; Kotler DP; Fasano A; Green PH; Department of Surgical Pathology, Columbia University College of; Physicians and Surgeons, New York, NY 10032, USA.; BACKGROUND: Scalloping of duodenal folds as well as a mosaic mucosal pattern, decreased folds, and increased vascularity are markers of duodenal mucosal injury, the most common cause being celiac disease. We have recognized scalloping in patients with a variety of conditions other than celiac disease. METHODS: Clinica
Phase II study of 3-hour infusion of high dose paclitaxel in refractory and relapsed aggressive non-Hodgkin's lymphomas. Groupe d'Etude des Lymphomes de l'Adulte.: Haematologica. 2000 May;85(5):502-7. Unique Identifier : AIDSLINE MED/20261487; Casasnovas RO; Haioun C; Dumontet C; Gabarre J; Richard B; Lederlin P; Caillot D; Stamatoullas A; Morel P; Quesnel B; Blay JY; Bouabdallah K; Gisselbrecht C; Hematologie Clinique, Hopital Le Bocage CHU Dijon, 2104 Dijon; Cedex, France. hemato.clinique@planetb.fr; BACKGROUND AND OBJECTIVE: The first clinical studies of paclitaxel as a single agent for the treatment of relapsed or refractory low or intermediate grade non-Hodgkin s lymphomas (NHL) yielded controversial results regarding the response rates observed, mainly related to the dose and schedule of administration used. T
Influence of sample storage time and temperature on lymphocyte subset counts using a FACScount system [letter]: Haematologica. 2000 May;85(5):550-1. Unique Identifier : AIDSLINE MED/20261497; Ruiz AR; Fernandez IP; Perea Baena JM; de La Torre FJ; Ramirez GR
[Risk of transmission of viral disease by needle punctures and cuts in hospital health care workers]: Harefuah. 1998 Nov 1;135(9):337-9, 408. Unique Identifier : AIDSLINE MED/20369092; Mishal Y; Yosefy C; Hay E; Catz D; Ambon E; Schneider R; Emergency Dept., Barzilai Medical Center, Ashkelon.; The accidental exposure of the health care workers (HCW) to blood and blood products constitutes a danger for transmission of blood-borne pathogens and the development of severe diseases. Most attention is focused on exposure to the viruses of hepatitis B, C and human immunodeficiency. The objectives of this prospectio
Antigen dose defines T helper 1 and T helper 2 responses in the lungs of C57BL/6 and BALB/c mice independently of splenic responses.: Immunol Lett. 2000 May 1;72(2):119-26. Unique Identifier : AIDSLINE MED/20302673; Morokata T; Ishikawa J; Yamada T; Inflammation Research Pharmacology Laboratories, Institute for; Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21; Miyukigaoka, Tsukuba-shi, 305-8585, Ibaraki, Japan.; morokata@yamanouchi.co.jp; To investigate the effect of antigen dose on immune response, C57BL/6 and BALB/c mice were sensitized with aluminum hydroxide gel (alum)-precipitated ovalbumin (OVA) then challenged with aerosolized OVA. Low-dose sensitization (less than 8 &mgr;g of OVA) elicited T helper 2 (Th2)-type immunoglobulins (Igs) secretio
Strong alpha beta and gamma delta TCR response in a patient with disseminated Mycobacterium avium infection and lack of NK cells and monocytopenia.: Immunol Lett. 2000 May 1;72(2):75-82. Unique Identifier : AIDSLINE MED/20302667; Wendland T; Herren S; Yawalkar N; Cerny A; Pichler WJ; Clinic for Rheumatology and Clinical Immunology/Allergology,; University Hospital Bern, Freiburgstrasse, CH-3010, Bern,; Switzerland.; Infection with atypical mycobacteria occurs mainly in patients with a compromised cellular immune system, in particular in those with a defective T cell or monocyte function. Here we analyzed the specific immune response of an adolescent HIV-negative patient with disseminated mycobacterium avium infection and fatal va
Role of chaperones in antigen processing.: Immunol Invest. 2000 May;29(2):101-4. Unique Identifier : AIDSLINE MED/20311236; Nicchitta CV; Department of Cell Biology, Duke University Medical Center,; Durham, North Carolina 27710, USA.
The role of CD40-CD154 interactions in the regulation of cell mediated immunity.: Immunol Invest. 2000 May;29(2):111-4. Unique Identifier : AIDSLINE MED/20311238; Miga A; Masters S; Gonzalez M; Noelle RJ; Department of Microbiology, Dartmouth Medical School, Lebanon, NH; 03756, USA.; CD40 is expressed on a diverse array of cell types from the hematopoietic and non-hematopoietic compartments. Within the hematopoietic compartment, CD40 is found constitutively expressed on B cells, dendritic cells (DC) and macrophages. The function of CD40 in B cells has been documented as being essential in the cont
Amplification of T cell-mediated immune responses by antibody-cytokine fusion proteins.: Immunol Invest. 2000 May;29(2):117-20. Unique Identifier : AIDSLINE MED/20311239; Lode HN; Xiang R; Gillies SD; Reisfeld RA; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.
Approaches for immunotherapy of lymphomas.: Immunol Invest. 2000 May;29(2):93-5. Unique Identifier : AIDSLINE MED/20311234; Kwak LW; National Cancer Institute, Division of Clinical Sciences,; Bethesda, MD, USA.
Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.: Immunol Invest. 2000 May;29(2):97-100. Unique Identifier : AIDSLINE MED/20311235; Tortorella D; Gewurz B; Schust D; Furman M; Ploegh H; Harvard Medical School, Department of Pathology, Boston,; Massachusetts 02115, USA.
Suppression of experimental autoimmune tubulointerstitial nephritis in BALB/c mice by berberine.: Unique Identifier : AIDSLINE MED/20283569 P
The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation.: J Biol Chem. 2000 Jul 28;275(30):23097-105. Unique Identifier : AIDSLINE MED/20390066; Cohen GB; Rangan VS; Chen BK; Smith S; Baltimore D; AIDS Research Center, Massachusetts General Hospital, Harvard; Medical School, Charlestown, Massachusetts 02129, USA.; A HIV-1 Nef affinity column was used to purify a 35-kDa Nef-interacting protein from T-cell lysates. The 35-kDa protein was identified by peptide microsequence analysis as the human thioesterase II (hTE) enzyme, an enzyme previously identified in a yeast two-hybrid screen as a potential Nef-interacting protein. Immuno
The major head protein of bacteriophage T4 binds specifically to elongation factor Tu.: J Biol Chem. 2000 Jul 28;275(30):23219-26. Unique Identifier : AIDSLINE MED/20390084; Bingham R; Ekunwe SI; Falk S; Snyder L; Kleanthous C; School of Biological Sciences, University of East Anglia, Norwich; NR4 7TJ, United Kingdom.; The Lit protease in Escherichia coli K-12 strains induces cell death in response to bacteriophage T4 infection by cleaving translation elongation factor (EF) Tu and shutting down translation. Suicide of the cell is timed to the appearance late in the maturation of the phage of a short peptide sequence in the major hea
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease.: J Clin Endocrinol Metab. 2000 Aug;85(8):2775-8. Unique Identifier : AIDSLINE MED/20401704; Yamada T; Sato A; Komiya I; Nishimori T; Ito Y; Terao A; Eto S; Tanaka Y; Department of Medicine, Kashiwa City Hospital, Chiba, Japan.; In hyperthyroid Graves disease, short-term methimazole is sufficient to induce lasting remission in some patients, but even long-term treatment fails to do so in others. We have evaluated the role of autoimmune abnormalities in the helper T cell type 2 (TH2)-interleukin-13 (IL-13)-TSH receptor system in maintaining h
Il-4 and IFN-gamma mRNA induction in human peripheral lymphocytes specific for beta-lactam antibiotics in immediate or delayed hypersensitivity reactions.: J Clin Immunol. 2000 Mar;20(2):107-16. Unique Identifier : AIDSLINE MED/20279482; Gaspard I; Guinnepain MT; Laurent J; Bachot N; Kerdine S; Bertoglio J; Pallardy M; Lebrec H; INSERM U461, Faculte de Pharmacie, Chatenay-Malabry, France.; Beta-lactam antibiotics elicit CD4+ and CD8+ T-cell-mediated immune responses that play a central role in allergic reactions. However, the involvement of a type 1- (Th1 or Tc1) or a type 2-like (Th2 or Tc2) differentiation in drug allergy remains unclear. We investigated the expression of interleukin 4 (IL-4) and inte
Elevated plasma levels of 90K (Mac-2 BP) immunostimulatory glycoprotein in HIV-1-infected children.: J Clin Immunol. 2000 Mar;20(2):117-22. Unique Identifier : AIDSLINE MED/20279483; Groschel B; Braner JJ; Funk M; Linde R; Doerr HW; Cinatl J Jr; Iacobelli S; Institute of Medical Virology, Johann Wolfgang Goethe University,; Frankfurt/M., Germany.; 90K is a secreted serum glycoprotein with immune stimulatory activity. In this study, 90K plasma levels were determined by an enzyme-linked immunosorbent assay in 18 HIV-1-infected children and 10 uninfected control children. 90K levels in HIV-1-infected children (median, 12.5 microg/ml) were higher than in HIV-1 unin
Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene.: J Neuroimmunol. 2000 Aug 1;108(1-2):112-21. Unique Identifier : AIDSLINE MED/20361884; Koustova E; Sei Y; McCarty T; Espey MG; Ming R; Morse HC 3rd; Basile AS; Laboratory of Bioorganic Chemistry, Building 8, Room 1A15, MSC; 0826, NIDDK, NIH, Bethesda, MD 20892, USA.; Mice homozygous for a germline deletion of the interferon-gamma gene (IFN-gamma (-/-)) were infected with the LP-BM5 (BM5) retrovirus mixture to determine if the inability to produce IFN-gamma reduces collateral CNS damage associated with chronic neuroinflammation. Virus burdens in spleens and brains of infected mice
The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents.: BOLISM J Neuroimmunol. 2000 Aug 1;108(1-2):136-46. Unique Identifier : AIDSLINE MED/20361887; Dinter H; Tse J; Halks-Miller M; Asarnow D; Onuffer J; Faulds D; Mitrovic B; Kirsch G; Laurent H; Esperling P; Seidelmann D; Ottow E; Schneider H; Tuohy VK; Wachtel H; Perez HD; Department of Immunology, Berlex Biosciences, 15049 San Pablo; Ave., Richmond, CA 94804, USA. Harold_Dinter@Berlex.com; (range: 1.4% in London and 52.6% in Madrid).A
Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients.: J Neuroimmunol. 2000 Aug 1;108(1-2):201-6. Unique Identifier : AIDSLINE MED/20361894; Qin Y; Zhang DQ; Prat A; Pouly S; Antel J; Neuroimmunology Unit, Montreal Neurological Institute, McGill; University, 3801 University Street, Quebec, H3A 2B4, Montreal,; Canada.; We analyzed the effects of glatiramer acetate (GA) therapy on in vitro proliferative responses and cytokine production by lymphocytes derived from multiple sclerosis patients receiving this therapy. We confirmed that lymphocytes derived from GA naive patients show a high frequency of response when initially exposed to
Evidence of cerebrospinal fluid free kappa light chains in AIDS patients with Toxoplasma gondii encephalitis.: J Neuroimmunol. 2000 Aug 1;108(1-2):221-6. Unique Identifier : AIDSLINE MED/20361897; Contini C; Fainardi E; Cultrera R; Seraceni S; Castellazzi M; Peyron F; Granieri E; Section of Infectious Diseases, Department of Clinical and; Experimental Medicine, Via Fossato di Mortara 23, University of; Ferrara, I-44100, Ferrara, Italy. cnc@ifeuniv.unife.it; Cerebrospinal fluid (CSF) free light chains of kappa or lambda (FLC kappa/lambda) type were investigated by affinity mediated blotting technique (AMI) and ELISA in 28 patients of which nine with AIDS and Toxoplasma gondii encephalitis (AIDS, TE), 11 with AIDS with or without other CNS AIDS-related opportunistic infect
T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis.: J Neuroimmunol. 2000 Aug 1;108(1-2):29-39. Unique Identifier : AIDSLINE MED/20361874; Wang ZY; Diethelm-Okita B; Okita DK; Kaminski HJ; Howard JF; Conti-Fine BM; Department of Biochemistry, Molecular Biology and Biophysics,; University of Minnesota, Twin Cities Campus, Minnesota MN 55108,; USA.; We examined the proliferative response of blood CD4(+) cells to muscle acetylcholine receptor (AChR) subunits and the epitope repertoire of the epsilon and gamma subunits, in ocular myasthenia gravis (oMG) patients and healthy subjects. oMG patients seldom recognized all subunits. The frequency and intensity of recogn
A plasmid construct encoding murine interferon beta antagonizes the replication of herpes simplex virus type I in vitro and in vivo.: J Neuroimmunol. 2000 Aug 1;108(1-2):92-102. Unique Identifier : AIDSLINE MED/20361882; Cui B; Carr DJ; Department of Microbiology, Immunology, and Parasitology,; Louisiana State University Health Sciences Center, New Orleans,; LA, USA.; In the present study, we employed a plasmid DNA encoding murine interferon (IFN)-beta to assess its antiviral efficacy in an in vitro transfection-infection assay and in an ocular HSV-1 infection model of mice. In the in vitro assay, transfection of mouse fibroblasts with the IFN-beta transgene resulted in a 17-fold o
Molecular techniques for clinical diagnostic virology.: J Clin Pathol. 2000 Jul;53(7):502-6. Unique Identifier : AIDSLINE MED/20416856; Read SJ; Burnett D; Fink CG; Micropathology Ltd, University of Warwick Science Park, Barclays; Venture Centre, Coventry, UK. micropathology@telinco.co.uk
Impact of a multi-method promotional package on awareness and knowledge about STD and AIDS among the trainees of an industrial training institute in a resettlement colony of Delhi, India.: J Commun Dis. 1999 Dec;31(4):209-16. Unique Identifier : AIDSLINE MED/20392987; Chaturvedi S; Gupta P; Rajoura OP; Kumar P; Aggarwal OP; University College of Medical Sciences, Delhi, India.; To design and apply a multi-method promotional package for enhancing awareness and knowledge on STD and AIDS among ITI trainees, and evaluate its impact, an intervention study, using pre and post assessment of the subjects for comparison was carried out. The study was carried out in the Industrial Training Institute (
AIDS-related apprehensions among nursing students of Delhi.: J Commun Dis. 1999 Dec;31(4):217-21. Unique Identifier : AIDSLINE MED/20392988; Kumar A; Lal P; Ingle GK; Gulati N; National Institute of Communicable Disease, Sham Nath Marg,; Delhi.; Students from a nursing school of Delhi were surveyed anonymously using a self-administered questionnaire to explore various AIDS-related apprehensions and their possible reasons. The observations revealed that, majority of the students and their families/friends feared that these students were at risk of contracting
Incidence of HTLV-I in high-risk population in Delhi.: J Commun Dis. 1999 Dec;31(4):237-40. Unique Identifier : AIDSLINE MED/20392991; Varma M; Mehta G; Patel Chest Institute, University of Delhi.; Human infection due to HTLV-I occurs by transmission of infected T-cells via sexual intercourse, blood transfusion or breastfeeding. The present investigation was carried out to find the incidence of HTLV-I in high risk population and its relationship with syphilis and HIV infection. The study group comprised 124 ante
Current issues and update on human immunodeficiency virus infection in the orthopaedic setting.: Instr Course Lect. 2000;49:621-5. Unique Identifier : AIDSLINE MED/20288027; Panlilio AL; HIV Infections Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; The risk of HIV transmission in the health care setting is a composite of risks, with exposure to blood being the most important source of infection and percutaneous injuries posing the greatest risk of transmission. The frequency of blood contact varies by occupation, procedure performed, and precautions used. Data s
Issues and update on HIV infection in orthopaedic surgery: risk of surgery on HIV-infected patients.: Instr Course Lect. 2000;49:627-9. Unique Identifier : AIDSLINE MED/20288028; Wiedel JD; Department of Orthopaedics, University of Colorado Health; Sciences Center, Denver, USA.
Poliovirus-specific intestinal antibody responses coincide with decline of poliovirus excretion.: J Infect Dis. 2000 Jul;182(1):1-5. Unique Identifier : AIDSLINE MED/20341724; Valtanen S; Roivainen M; Piirainen L; Stenvik M; Hovi T; Department of Biochemistry, National Public Health Institute,; Helsinki, Finland. sanna.valtanen@ktl.fi; Antibody responses to poliovirus type 3 were studied in fecal samples of 66 children immunized with 3 doses of enhanced-potency inactivated poliovirus vaccine (E-IPV), followed by 1 dose of monovalent oral poliovirus vaccine (OPV, type 3 Sabin). One fecal sample taken before OPV vaccination and 9 collected thereafter
Disease progression and early viral dynamics in human immunodeficiency virus-infected children exposed to zidovudine during prenatal and perinatal periods.: J Infect Dis. 2000 Jul;182(1):104-11. Unique Identifier : AIDSLINE MED/20341737; Kuhn L; Abrams EJ; Weedon J; Lambert G; Schoenbaum EE; Nesheim SR; Palumbo P; Vink PE; Bulterys M; Columbia University, Sergievsky Center, New York, NY 10032, USA.; lk24@columbia.edu; Zidovudine (Zdv) is widely used to reduce maternal-infant human immunodeficiency virus transmission (HIV), but its consequences for disease progression among children infected despite Zdv exposure remain unknown. In a multicenter observational cohort study of 325 HIV-infected children born during 1986-1997, clinical p
Selection of drug-resistant variants in the female genital tract of human immunodeficiency virus type 1-infected women receiving antiretroviral therapy.: J Infect Dis. 2000 Jul;182(1):112-22. Unique Identifier : AIDSLINE MED/20341738; Si-Mohamed A; Kazatchkine MD; Heard I; Goujon C; Prazuck T; Aymard G; Cessot G; Kuo YH; Bernard MC; Diquet B; Malkin JE; Gutmann L; Belec L; Laboratoire de Virologie, Hopital Broussais/Hopital Europeen; Georges Pompidou, Paris, France.; We investigated human immunodeficiency virus (HIV) type 1 RNA, proviral DNA, and antiretroviral drug-resistant variants in cervicovaginal secretions of HIV-1-infected women receiving antiretroviral therapy. The prevalence of detectable HIV-1 RNA in genital secretions was inversely related to the number of antiretrovir
Factors contributing to the lack of human immunodeficiency virus type 1 (HIV-1) transmission in HIV-1-discordant partners.: J Infect Dis. 2000 Jul;182(1):123-32. Unique Identifier : AIDSLINE MED/20341739; Bienzle D; MacDonald KS; Smaill FM; Kovacs C; Baqi M; Courssaris B; Luscher MA; Walmsley SL; Rosenthal KL; Department of Pathobiology, University of Guelph, Guelph,; Ontario, Canada. dbienzle@ovc.uoguelph.ca; Correlates of resistance to infection by human immunodeficiency virus type 1 (HIV-1) are important for defining potential therapeutic interventions and for prophylactic vaccination. In this study, 11 couples discordant in their HIV-1 infection status were prospectively evaluated for the presence of protective factors.
Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses.: J Infect Dis. 2000 Jul;182(1):180-90. Unique Identifier : AIDSLINE MED/20341746; Yamamoto M; Kiyono H; Kweon MN; Yamamoto S; Fujihashi K; Kurazono H; Imaoka K; Bluethmann H; Takahashi I; Takeda Y; Azuma M; McGhee JR; Department of Clinical Pathology, Nihon University School of; Dentistry at Matsudo, Chiba, Japan.; In an in vitro study, Escherichia coli heat-labile toxin (LT) was shown to directly affect activated CD4(+) T cells and support interleukin (IL)-5 production in IL-4-deficient (IL-4(-/-)) mice, whereas cholera toxin (CT) did not. Both LT and CT enhanced B7-2 expression on B cells and macrophages. These effects were no
Chronic schistosomiasis: dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness.: J Infect Dis. 2000 Jul;182(1):260-5. Unique Identifier : AIDSLINE MED/20341755; van Den Biggelaar AH; Grogan JL; Filie Y; Jordens R; Kremsner PG; Koning F; Yazdanbakhsh M; Department of Parasitology, Leiden University Medical Center,; 2300 RC Leiden, The Netherlands. A.H.J.van_den_Biggelar@LUMC.NL; Chronic infection with helminths is associated with down-regulated antigen-specific T cell responses. In order to determine whether schistosome-specific T cells are present, yet functionally unresponsive, or absent in the periphery of chronically infected persons, autologous granulocyte-macrophage colony-stimulating f
Evaluation of the latency-associated nuclear antigen (ORF73) of Kaposi's sarcoma-associated herpesvirus by peptide mapping and bacterially expressed recombinant western blot assay.: J Infect Dis. 2000 Jul;182(1):306-10. Unique Identifier : AIDSLINE MED/20341763; Olsen SJ; Sarid R; Chang Y; Moore PS; Division of Baterial and Mycotic Diseases, Centers for Disease; COntrol and Prevention, Atlanta, GA 30333, USA. sco2@cdc.gov; Kaposi s sarcoma (KS)-associated herpesvirus open-reading frame (ORF) 73 encodes a latency-associated nuclear antigen (LANA) that is the basis for several serologic assays. Immunoreactive epitopes were searched for by peptide mapping, and 171 cleavable, biotinylated 17-mer peptides offset by 5 residues were synthesize
Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection.: J Infect Dis. 2000 Jul;182(1):311-5. Unique Identifier : AIDSLINE MED/20341764; Brambilla A; Villa C; Rizzardi G; Veglia F; Ghezzi S; Lazzarin A; Cusini M; Muratori S; Santagostino E; Gringeri A; Louie LG; Sheppard HW; Poli G; Michael NL; Pantaleo G; Vicenzi E; AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute,; Milan, Italy.; The SDF-1 3 A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant associa
Analysis of env sequence evolution in human immunodeficiency virus-infected patients receiving therapy with nonnucleoside reverse-transcriptase inhibitors.: J Infect Dis. 2000 Jul;182(1):316-20. Unique Identifier : AIDSLINE MED/20341765; Dykes C; Mootsikapun P; Dexter A; Berrios L; Chiulli M; Reichman RC; Demeter LM; Infectious Diseases Unit, University of Rochester School of; Medicine and Dentistry, Rochester, NY 14642, USA.; Carrie_Dykes@urmc.rochester.edu; Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used the heteroduplex t
In vivo antagonism with zidovudine plus stavudine combination therapy.: J Infect Dis. 2000 Jul;182(1):321-5. Unique Identifier : AIDSLINE MED/20341766; Havlir DV; Tierney C; Friedland GH; Pollard RB; Smeaton L; Sommadossi JP; Fox L; Kessler H; Fife KH; Richman DD; 1University of California, San Diego, 2San Diego VA Medical; Center, San Diego, California, USA. dhavlir@ucsd.edu; Human immunodeficiency virus (HIV)-infected subjects receiving zidovudine were randomized either to add stavudine ( d4T ) or didanosine (ddI) to their current regimen or to switch to dd
Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults.: J Infect Dis. 2000 Jul;182(1):326-9. Unique Identifier : AIDSLINE MED/20341767; Jacobson JM; Lowy I; Fletcher CV; O'Neill TJ; Tran DN; Ketas TJ; Trkola A; Klotman ME; Maddon PJ; Olson WC; Israel RJ; Mount Sinai Medical Center, New York, NY 10029-6574, USA.; jeffrey.jacobson@mssm.edu; PRO 542 (CD4-IgG2) is a recombinant antibody-like fusion protein wherein the Fv portions of both the heavy and light chains of human IgG2 have been replaced with the D1D2 domains of human CD4. Unlike monovalent and divalent CD4-based proteins, tetravalent PRO 542 potently neutralizes diverse primary human immunodefici
Prevalence of mutations associated with reduced antiretroviral drug susceptibility among human immunodeficiency virus type 1 seroconverters in the United States, 1993-1998.: J Infect Dis. 2000 Jul;182(1):330-3. Unique Identifier : AIDSLINE MED/20341768; Weinstock H; Respess R; Heneine W; Petropoulos CJ; Hellmann NS; Luo CC; Pau CP; Woods T; Gwinn M; Kaplan J; Centers for Disease Control and Prevention, Atlanta, GA 30333.; hsw2@cdc.gov; To assess the prevalence of mutations associated with decreased antiretroviral drug susceptibility, specimens were tested from persons infected with human immunodeficiency virus (HIV) during 1993-1998. Subjects were drug naive and were attending sexually transmitted disease clinics in 6 US cities. All were enrolled co
Incubation time of acute human immunodeficiency virus (HIV) infection and duration of acute HIV infection are independent prognostic factors of progression to AIDS.: J Infect Dis. 2000 Jul;182(1):334-7. Unique Identifier : AIDSLINE MED/20341769; Vanhems P; Hirschel B; Phillips AN; Cooper DA; Vizzard J; Brassard J; Perrin L; Laboratoire d'Epidemiologie et de Sante Publique, Universite; Claude Bernard Lyon 1, 8, av. Rockefeller, 69373 Lyon Cedex 08,; France. philipva@lyon-sud.univ-lyon1.fr; The severity and the duration of acute human immunodeficiency virus (HIV) infection (AHI) are associated with a faster rate of progression to AIDS, but the prognostic value of the length of incubation time of AHI (IncAHI), defined as the time between HIV infection and AHI, on progression to AIDS has not been assessed.
In vivo cytolysis and fusion of human immunodeficiency virus type 1-infected lymphocytes in lymphoid tissue.: J Infect Dis. 2000 Jul;182(1):338-42. Unique Identifier : AIDSLINE MED/20341770; Orenstein JM; Department of Pathology, George Washington University Medical; Center, Washington, DC 20037, USA. patjmo@gwumc.edu.; Lymphoid tissue was examined to see whether in vivo cytopathic effects of human immunodeficiency virus (HIV) infection on lymphocytes could be detected. Transmission electron microscopy of mechanical suspensions prepared from lymph nodes showed both replication and phagocytosis of HIV particles by macrophages. Phagoso
Sex and shedding of human immunodeficiency virus [letter; comment]: J Infect Dis. 2000 Jul;182(1):375-6. Unique Identifier : AIDSLINE MED/20341779; Cohen P
Detection of cytomegalovirus late (pp150) antigen in peripheral blood leukocytes of patients with human immunodeficiency virus-related lymphoma [letter; comment]: J Infect Dis. 2000 Jul;182(1):376-9. Unique Identifier : AIDSLINE MED/20341780; Gentile G; Capobianchi A; Gastaldi R; Rolli M; Capucci S; Girmenia C; Martino P
Possible mechanism for positive interaction of human T cell leukemia type I on liver disease in a hepatitis C virus-infected Japanese cohort [letter; comment]: J Infect Dis. 2000 Jul;182(1):379-80. Unique Identifier : AIDSLINE MED/20341783; Casseb J
Structural prerequisites for intersubtype B and D antigenicity of the third variable envelope region (V3) of human immunodeficiency virus type 1.: J Infect Dis. 2000 Jul;182(1):49-58. Unique Identifier : AIDSLINE MED/20341731; Lawoko A; Johansson B; Ljunggren J; Fries A; Fredriksson R; Georgievska L; Malmvall B; Pipkorn R; Fenyo EM; Blomberg J; Department of Medical Sciences, Section of Virology, Uppsala; Academic Hospital, S-751 85 Uppsala, Sweden.; To elucidate the structural requirements for intersubtype antigenicity of human immunodeficiency virus type 1 (HIV-1) third variable envelope region (V3), synthetic peptides were used in enzyme immunoassays (EIAs) with serum samples from persons with proven or probable subtype B and D infections. Mathematical analyses
Methods for investigation of the relationship between drug-susceptibility phenotype and human immunodeficiency virus type 1 genotype with applications to AIDS clinical trials group 333.: J Infect Dis. 2000 Jul;182(1):59-67. Unique Identifier : AIDSLINE MED/20341732; Sevin AD; DeGruttola V; Nijhuis M; Schapiro JM; Foulkes AS; Para MF; Boucher CA; Center for Biostatistics in AIDS Research, Harvard School of; Public Health, Boston, MA 02115-6018, USA.; asevin@sdac.harvard.edu; Use of human immunodeficiency virus (HIV) drug-resistance testing in therapeutic decision making may be aided by understanding the relationship between results of genotypic and drug-susceptibility phenotypic assays. We investigated this relationship by applying 3 different statistical methods-cluster analysis, recursi
Consistent and significant inhibition of human immunodeficiency virus type 1 envelope-mediated membrane fusion by beta-chemokines (RANTES) in primary human macrophages.: J Infect Dis. 2000 Jul;182(1):68-78. Unique Identifier : AIDSLINE MED/20341733; Stantchev TS; Broder CC; Department of Microbiology and Immunology, F. Edward Hebert; School of Medicine, Uniformed Services University of the Health; Sciences, Bethesda, MD 20814-4799, USA. tstanchev@mxb.usuhs.mil; Infection and entry of CD4(+) cells by human immunodeficiency virus type 1 (HIV-1) requires a coreceptor molecule, which, in concert with CD4, interacts with the viral envelope glycoprotein (Env), leading to membrane fusion. The principal coreceptors are the CCR5 and CXCR4 chemokine receptors. The suppressive effect o
Human immunodeficiency virus type 1 shedding pattern in semen correlates with the compartmentalization of viral Quasi species between blood and semen.: J Infect Dis. 2000 Jul;182(1):79-87. Unique Identifier : AIDSLINE MED/20341734; Gupta P; Leroux C; Patterson BK; Kingsley L; Rinaldo C; Ding M; Chen Y; Kulka K; Buchanan W; McKeon B; Montelaro R; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pittsburgh, PA; 15261, USA. pgupta1+@pitt.edu; High levels of human immunodeficiency virus (HIV) type 1 have been detected in semen at all stages of disease. However, it is not clear whether HIV-1 is shed in semen continuously or intermittently. In a prospective longitudinal study, viral RNA was measured weekly for 10 weeks in semen and blood of HIV-seropositive s
The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children.: J Infect Dis. 2000 Jul;182(1):88-95. Unique Identifier : AIDSLINE MED/20341735; Spiegel HM; Chandwani R; Sheehy ME; Dobroszycki J; Fennelly G; Wiznia A; Radding J; Rigaud M; Pollack H; Borkowsky W; Rosenberg M; Nixon DF; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, NY 10016, USA. hspiegel@adarc.org hspiegel@adarc.org; This cross-sectional study investigated the effect of early highly active antiretroviral therapy (HAART) on human immunodeficiency virus (HIV) type 1-specific CD8 T cell responses in children. HIV-1-specific CD8 T cell responses were quantified using an enzyme-linked immunospot assay to measure interferon-gamma-secret
Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected children.: J Infect Dis. 2000 Jul;182(1):96-103. Unique Identifier : AIDSLINE MED/20341736; Borkowsky W; Stanley K; Douglas SD; Lee S; Wiznia A; Pelton S; Yogev R; McIntosh K; Nachman S; Division of Infectious Diseases, New York University School of; Medicine, New York, NY 10016, USA. borkow01@mcgc16.med.nyu.edu; The response of 40 immunologic parameters was studied for 147 clinically stable, protease inhibitor-naive, human immunodeficiency virus (HIV)-infected children aged 2-17 years when antiretroviral therapy was changed to either a dual nucleoside analogue regimen or a protease inhibitor-containing regimen. Immunologic re
[HIV-1 (human immunodeficiency virus type 1) mutant strain associated with zidovudine resistance detected from a Japanese patient with primary HIV-1 infection]: Kansenshogaku Zasshi. 2000 Apr;74(4):360-4. Unique Identifier : AIDSLINE MED/20295549; Usuku S; Noguchi Y; Sakamoto M; Sagara H; Sudo K; Kondo M; Imai M; Yokohama City Institute of Health.; Sequences of HIV-1 pol gene were determined by direct sequencing from a Japanese patient with primary HIV-1 infection. The patient did not receive antiretroviral therapies. However we observed a HIV-1 mutant strain associated with zidovudine (ZDV) resistance. The patient had both the codon 70 and the codon 215 amino a
Innate and adaptive immunity in Candida albicans infections and saprophytism.: J Leukoc Biol. 2000 Aug;68(2):175-9. Unique Identifier : AIDSLINE MED/20401884; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy. lromani@unipg.it; Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of
Influence of type 2 T cell responses on the severity of encephalitis associated with influenza virus infection.: Unique Identifier : AIDSLINE MED/20401885; Kaji M; Kobayashi M; Pollard RB; Suzuki F; The role of type 2 T cell responses on the severity of post-infectious encephalitis was investigated in a mouse model of influenza virus infection. When mice were infected intracerebrally with 3.0 LD(50) of A/NWS33 strain of influenza virus, they all showed clinical signs of encephalitis, and 90% of
Predictive value of the ultrasensitive HIV viral load assay in clinical practice.: J Med Virol. 2000 Aug;61(4):411-6. Unique Identifier : AIDSLINE MED/20357694; Muir D; White D; King J; Verlander N; Pillay D; Public Health Laboratory and PHLS Antiviral Susceptibility; Reference Unit, Birmingham Heartlands Hospital and University of; Birmingham Medical School, United Kingdom.; The aim of this study was to determine whether an HIV viral load of
Accuracy of plasma HIV RNA quantification: a multicentre study of variability.: J Med Virol. 2000 Aug;61(4):417-22. Unique Identifier : AIDSLINE MED/20357695; Skidmore SJ; Zuckerman M; Parry JV; Public Health Laboratory, Heartlands Hospital, Birmingham, United; Kingdom.; Inaccurate quantification of plasma HIV RNA concentration may be detrimental to patient care, yet little is known about how reproducible results are within and between laboratories. Each week between January and April 1998 a different laboratory represented at the Public Health Laboratory Service HIV Diagnosis Forum s
Analysis of a human immunodeficiency virus type 1 gag mutant with an engineered 110-amino-acid insertion in the matrix protein domain.: J Med Virol. 2000 Aug;61(4):423-32. Unique Identifier : AIDSLINE MED/20357696; Wang CT; Yang AH; Chiang CC; Institute of Clinical Medicine, National Yang-Ming University; School of Medicine, Taiwan, Republic of China.; ctwang@vghtpe.gov.tw; A human immunodeficiency virus (HIV) matrix (MA) protein mutant was constructed by duplication of 107 codons of the HIV-1 MA domain. This MA protein duplication mutant (MAII) still could assemble and process particles, had a wild-type (wt) HIV particle density, and possessed reverse transcriptase activity of about 80%
Detection of TT virus DNA in patients with liver disease and recipients of liver transplant.: J Med Virol. 2000 Aug;61(4):455-61. Unique Identifier : AIDSLINE MED/20357700; Shang D; Lin YH; Rigopoulou I; Chen B; Alexander GJ; Allain JP; Department of Haematology, Division of Transfusion Medicine, East; Anglia Blood Centre, Cambridge, United Kingdom.; TT virus (TTV) is transfusion-transmissible but its involvement in post-transfusion hepatitis is uncertain. To investigate the potential association of TTV with liver diseases, the prevalence of TTV DNA was tested by semi-nested PCR in 113 carriers of hepatitis C virus (HCV), 10 patients with acute liver failure, 11 p
Human cytomegalovirus strains associated with congenital and perinatal infections.: J Med Virol. 2000 Aug;61(4):481-7. Unique Identifier : AIDSLINE MED/20357704; Trincado DE; Scott GM; White PA; Hunt C; Rasmussen L; Rawlinson WD; Virology Division, Department of Microbiology, South Eastern Area; Laboratory Services, The Prince of Wales Hospital, Randwick,; Australia.; The genotypes of human cytomegalovirus (HCMV) isolates from pediatric patients differs from those of infected adults in Australia . Genotypes were determined by PCR amplification of glycoprotein B (gB) sequences, with subsequent analysis by re
Detection of reverse transcriptase activity in the serum of patients with motor neurone disease.: J Med Virol. 2000 Aug;61(4):527-32. Unique Identifier : AIDSLINE MED/20357710; Andrews WD; Tuke PW; Al-Chalabi A; Gaudin P; Ijaz S; Parton MJ; Garson JA; Department of Virology, Royal Free and University College Medical; School, London, United Kingdom.; The recognition that both human and murine retroviruses can cause motor neurone disease-like syndromes has raised the possibility that a retrovirus may be involved in the aetiology of motor neurone disease. This possibility was explored by looking for evidence of reverse transcriptase in the serum of motor neurone dis
Nutritional factors and infectious disease contribute to anemia among pregnant women with human immunodeficiency virus in Tanzania.: J Nutr. 2000 Aug;130(8):1950-7. Unique Identifier : AIDSLINE MED/20377638; Antelman G; Msamanga GI; Spiegelman D; Urassa EJ; Narh R; Hunter DJ; Fawzi WW; Departments of Nutrition, Biostatistics and Epidemiology, Harvard; School of Public Health, Boston MA, 02115, USA.; The objective of this cross-sectional study was to identify risk factors for anemia among human immunodeficiency virus (HIV)-positive pregnant women in Dar es Salaam, Tanzania . Baseline data from 1064 women enrolled in a clinical trial on the effect of vitamin supplementation in
Coronary artery bypass grafting in a patient with human immunodeficiency virus: role of perioperative active anti-retroviral therapy.: Jpn Circ J. 1999 May;63(5):423-4. Unique Identifier : AIDSLINE MED/20397538; Imanaka K; Takamoto S; Kimura S; Morisawa Y; Ohtsuka T; Suematsu Y; Shirai T; Inoue K; Department of Cardiothroacic Surgery, University of Tokyo, Japan.; In a patient with severe ischemic heart disease and advanced human immunodeficiency virus (HIV) infection, vigorous perioperative treatment with anti-retroviral agents was given and coronary artery bypass surgery using cardiopulmonary bypass was successfully performed. This strategy could become the standard for patie
[Influence of a day care hospital on the incidence of hospital admission of AIDS patients]: Unique Identifier : AIDSLINE MED/20373501 P; Hernando A; Pulido F
Effect of thalidomide on gastrointestinal toxic effects of irinotecan [letter]: Lancet. 2000 Aug 12;356(9229):566-7. Unique Identifier : AIDSLINE MED/20405171; Govindarajan R; Heaton KM; Broadwater R; Zeitlin A; Lang NP; Hauer-Jensen M; Irinotecan is the only accepted second-line treatment for colorectal cancer in the USA. Doses are, however, frequently limited by associated late-onset diarrhoea. Thalidomide has antiangiogenic and immunomodulatory properties and is being investigated as an antineoplastic. We did a pilot study of
Primary prevention of HIV-1 [letter; comment]: Lancet. 2000 Aug 12;356(9229):600. Unique Identifier : AIDSLINE MED/20405202; Weisburger JH
Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group [see comments]: Medicine (Baltimore). 2000 Jul;79(4):250-60. Unique Identifier : AIDSLINE MED/20396949; Patterson TF; Kirkpatrick WR; White M; Hiemenz JW; Wingard JR; Dupont B; Rinaldi MG; Stevens DA; Graybill JR; Division of Infectious Diseases, University of Texas Health; Science Center, San Antonio 78284-7881, USA.; patterson@uthscsa.edu; A review of representative cases of invasive aspergillosis was conducted to describe current treatment practices and outcomes. Eighty-nine physicians experienced with aspergillosis completed case forms on 595 patients with proven or probable invasive aspergillosis diagnosed using modifications of the Mycoses Study Gro
Central nervous system aspergillosis in patients with human immunodeficiency virus infection. Report of 6 cases and review [see comments]: Medicine (Baltimore). 2000 Jul;79(4):269-80. Unique Identifier : AIDSLINE MED/20396951; Mylonakis E; Paliou M; Sax PE; Skolnik PR; Baron MJ; Rich JD; Infectious Disease Division, Massachusetts General Hospital,; Boston 02114-2696, USA. emylonakis@partners.org; Central nervous system (CNS) aspergillosis is a relatively uncommon complication of human immunodeficiency virus (HIV) infection. We describe 6 patients with the acquired immunodeficiency syndrome (AIDS) who developed CNS aspergillosis, and we review a total of 33 cases of CNS aspergillosis among HIV-infected individu
Immunological evaluation of human immunodeficiency virus infected individuals by flow cytometry.: Mem Inst Oswaldo Cruz. 2000 May-Jun;95(3):393-400. Unique Identifier : AIDSLINE MED/20261817; Neves I Jr; Morgado M; Laboratorio de Aids e Imunologia Molecular, Departamento de; Imunologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.; Human immunodeficiency virus (HIV) infection heavily compromises the immune system. The decrease of the T cell CD4+ subset along the evolution to acquired immunodeficiency syndrome has been considered as a hallmark of HIV infection. In this paper we review some aspects of the immunopathology of HIV infection and discu
Flow cytometry in the study of cell death.: Mem Inst Oswaldo Cruz. 2000 May-Jun;95(3):429-33. Unique Identifier : AIDSLINE MED/20261821; Bertho AL; Santiago MA; Coutinho SG; Laboratorio de Imunidade Celular e Humoral, Departamento de; Protozoologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.; bertho@fiocruz.br; In this report we present a concise review concerning the use of flow cytometric methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis. The applications of these techniques to clinical and basic research are also considered. The following cell features are use
Risk factors for tuberculosis among human immunodeficiency virus-infected persons. A case-control study in Belo Horizonte, Minas Gerais, Brazil (1985-1996).: Mem Inst Oswaldo Cruz. 2000 Jul-Aug;95(4):437-43. Unique Identifier : AIDSLINE MED/20366382; de Castro Toledo AC Jr; Greco DB; Antunes CM; Servico de Doencas Infecciosas e Parasitarias, Faculdade de; Medicina, Universidade Federal de Minas Gerais, Belo Horizonte,; MG, Brasil. toledoac@ig.com.br; The objective of this study was to identify tuberculosis risk factors and possible surrogate markers among human immunodeficiency virus (HIV)-infected persons. A retrospective case-control study was carried out at the HIV outpatient clinic of the Universidade Federal de Minas Gerais in Belo Horizonte. We reviewed the
Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.: Mol Cell Biol. 2000 Aug;20(16):5897-907. Unique Identifier : AIDSLINE MED/20372723; Fong YW; Zhou Q; Department of Molecular and Cell Biology, University of; California at Berkeley, Berkeley, California 94720-3206, USA.; Tat stimulation of human immunodeficiency virus type 1 (HIV-1) transcription requires Tat-dependent recruitment of human positive transcription elongation factor b (P-TEFb) to the HIV-1 promoter and the formation on the trans-acting response element (TAR) RNA of a P-TEFb-Tat-TAR ternary complex. We show here that the
Animal propagation and genomic survey of a genotype 1 isolate of Cryptosporidium parvum.: Mol Biochem Parasitol. 2000 May;108(2):187-97. Unique Identifier : AIDSLINE +; Widmer G; Akiyoshi D; Buckholt MA; Feng X; Rich SM; Deary KM; Bowman CA; Xu P; Wang Y; Wang X; Buck GA; Tzipori S; The Division of Infectious Diseases, Tufts University School of; Veterinary Medicine, 01536, North Grafton, MA, USA.; Human cryptosporidiosis is attributed to two major Cryptosporidium parvum genotypes of which type 1 appears to be the predominant. Most laboratory investigations however are performed using genotype 2 isolates, the only type which readily infects laboratory animals. So far type 1 has only been identified in humans and
[Prevalence of sexually transmitted diseases (STD) and HIV-infection among attendees of STD Outpatient Clinic, Dijkzigt University Hospital in Rotterdam; comparative analysis of years 1993 and 1998]: Ned Tijdschr Geneeskd. 2000 Jul 8;144(28):1351-5. Unique Identifier : AIDSLINE MED/20379446; van der Snoek EM; Chin-A-Lien RA; de Ridder MA; Willems PW; Verkooyen RP; van der Meijden WI; Academisch Ziekenhuis Rotterdam-Dijkzigt, afd.; Dermato-venerologie, Rotterdam.; OBJECTIVE: To gain an impression as to the possible trends in the prevalence of VD and HIV between 1993 and 1998. DESIGN: Retrospective. METHOD: Data of age, gender, ethnic background, sexual preference, intravenous drug use and a diagnosis of VD or HIV infection for persons attending the VD Outpatient Clinic of the D
A case of cerebral toxoplasmosis.: Neurol India. 2000 Jun;48(2):185-7. Unique Identifier : AIDSLINE MED/20342120; Alappat JP; Mathew CF; Jayakumar K; Suresh IC; Kumar S; Department of Neurosurgery, Medical College, Calicut, 673008,; India.; A histopathologically proven case of cerebral toxoplasmosis in a young HIV positive patient has been presented. The clinical problems in management are highlighted.
American Academy of Pediatrics. Committee on Infectious Diseases. Policy statement: recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine, and antibiotic prophylaxis.: Pediatrics. 2000 Aug;106(2 Pt 1):362-6. Unique Identifier : AIDSLINE MED/20381271; Heptavalent pneumococcal conjugate vaccine (PCV7) is recommended for universal use in children 23 months and younger, to be given concurrently with other recommended childhood vaccines at 2, 4, 6, and 12 to 15 months of age. For children 7 to 23 months old who have not received previous doses of PCV7, administration o
American Academy of Pediatrics. Committee on Infectious Diseases. Technical report: prevention of pneumococcal infections, including the use of pneumococcal conjugate and polysaccharide vaccines and antibiotic prophylaxis.: Pediatrics. 2000 Aug;106(2 Pt 1):367-76. Unique Identifier : AIDSLINE MED/20381272; Overturf GD; Pneumococcal infections are the most common invasive bacterial infections in children in the United States . The incidence of invasive pneumococcal infections peaks in children younger than 2 years, reaching rates of 228/100,000 in children 6 to 12 months old. Children with functional o
Detection of the 20-kDa virulence-associated antigen of Rhodococcus equi in malakoplakia-like lesion in pleural tissue obtained from an AIDS patient.: Pathol Res Pract. 2000;196(5):321-7; discussion 328. Unique Identifier : AIDSLINE MED/20292223; Caterino-de-Araujo A; de los Santos-Fortuna E; Zandona-Meleiro MC; Calore EE; Perez Calore NM; Immunology Department, Instituto Adolfo Lutz, Sao Paulo, SP,; Brazil. caterino@usp.br; A malakoplakia-like lesion was detected in a pleural biopsy from an AIDS patient presenting clinical and radiologic features of pneumonia. Cultures of bronchoalveolar lavage and pleural fluid evidenced Rhodococcus equi as the causative agent of pleuro-pulmonary infection. Immunochemical characterization of the R. equi
Recent HIV testing among general hospital inpatients with schizophrenia: findings from four New York City sites.: Psychiatr Q. 2000 Summer;71(2):177-93. Unique Identifier : AIDSLINE MED/20291622; Walkup J; McAlpine DD; Olfson M; Boyer C; Hansell S; Institute for Health, Health Care Policy, and Aging Research,; Rutgers University, New Brunswick, New Jersey 08901, USA.; walkup@rci.rutgers.edu, jaywalks@aol.com; BACKGROUND: While widely acknowledged to be an important clinical and public health issue, HIV assessment, counseling, and testing for the seriously mentally ill has not been well studied. OBJECTIVE: To determine what proportion and which inpatients with schizophrenia have been recently tested for HIV. METHOD: A sampl
Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography.: Radiographics. 2000 Jul-Aug;20(4):959-75; quiz 1108-9, 1112. Unique Identifier : AIDSLINE MED/20363880; Vitellas KM; Keogan MT; Freed KS; Enns RA; Spritzer CE; Baillie JM; Nelson RC; Department of Radiology, Ohio State University Medical Center,; Columbus, OH 43210, USA.; Magnetic resonance cholangiopancreatography (MRCP) is a relatively new, noninvasive cholangiographic technique that is comparable with invasive endoscopic retrograde cholangiopancreatography (ERCP) in the detection and characterization of extrahepatic bile duct abnormalities. The role of MRCP in evaluation of the intr
[Availability of voluntary prenatal HIV screening in primary health centers]: Rev Saude Publica. 1999 Dec;33(6):624-5. Unique Identifier : AIDSLINE MED/20156747; Neves FR; Passos AD; Gueleri WL; Programa de DST/Aids, Secretaria Municipal de Saude, Ribeirao; Preto, SP, Brasil.; A summary of the main steps towards the implementation of anti-HIV testing for pregnant women in the city is presented. Starting from August 1996, voluntary HIV testing became available to pregnant women seen at primary health centers in Ribeirao Preto, SP ( Brazil ), as part of the
P64k meningococcal protein as immunological carrier for weak immunogens.: Scand J Immunol. 2000 Aug;52(2):113-6. Unique Identifier : AIDSLINE MED/20389689; Gonzalez S; Alvarez A; Caballero E; Vina L; Guillen G; Silva R; Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Previously, the P64k meningococcal protein, an antigen of 64 kDa expressed in Escherichia coli, has been extensively characterized. We have successfully conjugated several synthetic peptides and meningococcal group C polysaccharide to P64k. In three out of four model peptides, the murine humoral immune response agains
T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation.: Scand J Immunol. 2000 Aug;52(2):123-30. Unique Identifier : AIDSLINE MED/20389691; Perola O; Ripatti A; Pelkonen J; Department of Clinical Microbiology, University of Kuopio,; Kuopio, Finland.; Owing to the contrasting observations in the field of interleukin(IL)-2 receptor research, the expression of IL-2 receptor chains was analysed on resting and anti-CD3 antibody (OKT3) activated CD4 and CD8 T cells by flow cytometry. Prior to the stimulation, 49% of CD4+
A soluble mannose receptor immunoadhesin enhances phagocytosis of Pneumocystis carinii by human polymorphonuclear leukocytes in vitro.: Scand J Immunol. 2000 Aug;52(2):131-7. Unique Identifier : AIDSLINE MED/20389692; Stehle SE; Rogers RA; Harmsen AG; Ezekowitz RA; Laboratory of Developmental Immunology, MassGeneral Hospital for; Children, and Harvard Medical School, Boston, Massachusetts; 02114, USA.; Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised hosts. In the normal host, P. carinii is susceptible to an array of first line host defense mechanisms that are operative in the lung. Alveolar macrophages play a central role in the clearance of inhaled organisms. The macroph
Expression of Fc(gamma)r1 (CD64) on polymorphonuclear leucocytes during progression to acquired immunodeficiency syndrome in perinatally human immunodeficiency virus-infected children.: Scand J Immunol. 2000 Aug;52(2):184-9. Unique Identifier : AIDSLINE MED/20389698; Moallem HJ; Kalayci O; Homel P; Fikrig S; Chice S; Durkin H; Michl J; Department of Pediatrics, State University of New York, Health; Science Center at Brooklyn, NY 11203, USA.; CD64, the high-affinity receptor in the family of FCgamma receptors, is not expressed constitutively in polymorphonuclear leucocytes (PMN). CD64 is expressed by PMNs in the late stages of human immunodeficiency virus (HIV) infection in adults. We followed the expression of CD64 on PMNs in perinatally HIV-infected chil
Effects of G-CSF on telomere lengths in PBMCs from human immunodeficiency virus-infected patients: results from a randomized, placebo-controlled trial.: Scand J Immunol. 2000 Aug;52(2):212-6. Unique Identifier : AIDSLINE MED/20389702; Aladdin H; Ullum H; Schjerling P; Skov Jensen M; Dam Nielsen S; Mathiesen L; Gerstoft J; Skinhoj P; Klarlund Pedersen B; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark. infdisha@rh.dk; Telomeres are unique terminal chromosomal structures, the length of which has been shown to decrease with cell division in vitro and with increased age in vivo for human somatic cells. In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is primarily found in CD8+ T cells, and not in CD4+ T c
Search for the origin of HIV and AIDS [letter; comment]: Science. 2000 Aug 18;289(5482):1140-1. Unique Identifier : AIDSLINE MED/20410275; Hooper E
Lay constructions of HIV and complementary therapy use.: Soc Sci Med. 2000 Jul;51(2):251-64. Unique Identifier : AIDSLINE MED/20290169; Pawluch D; Cain R; Gillett J; Department of Sociology, McMaster University, Hamilton, Ontario,; Canada. pawluch@mcmaster.ca; This study examines the meanings that individuals with HIV attach to their use of complementary therapies. A qualitative analysis of 66 interviews completed between 1993 and 1998 showed that complementary therapies represent different things for these individuals--a health maintenance strategy, a healing strategy, an
HIV/AIDS debate--time for a truce [editorial]: S Afr Med J. 2000 May;90(5):433. Unique Identifier : AIDSLINE MED/20360257; Ncayiyana DJ
HIV-positive test results [letter; comment]: S Afr Med J. 2000 May;90(5):449-50. Unique Identifier : AIDSLINE MED/20360261; Mankazana M
HIV surveillance results--little grounds for optimism yet.: S Afr Med J. 2000 May;90(5):452-3. Unique Identifier : AIDSLINE MED/20360264; Dorrington R; Bradshaw D; Bourne D; Karim SA
AIDS management options for SA [news]: S Afr Med J. 2000 May;90(5):461-3. Unique Identifier : AIDSLINE MED/20360269; Mbewu A; Matchaba P; Reddy S; Onyebujoh P
Mounting pressure on AIDS drug manufactures [news]: S Afr Med J. 2000 May;90(5):465. Unique Identifier : AIDSLINE MED/20360270
HIV infection, tuberculosis and non-tuberculous mycobacteria.: S Afr Med J. 2000 May;90(5):472-6. Unique Identifier : AIDSLINE MED/20360271; Churchyard GJ; Grant AD; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
Should the condom come with a health warning?: S Afr Med J. 2000 May;90(5):478-9. Unique Identifier : AIDSLINE MED/20360272; White G
IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis.: Surgery. 2000 Aug;128(2):133-8. Unique Identifier : AIDSLINE MED/20382820; Song GY; Chung CS; Chaudry IH; Ayala A; Center for Surgical Research and Department of Surgery, Brown; University School of Medicine and Rhode Island Hospital,; Providence, 02903, USA.; BACKGROUND: Although studies have shown that there is a marked depression in cell-mediated (T(H)(1)) immunity after the onset of sepsis, the mechanism by which this occurs remains unknown. In this regard, the T(H2) cytokine IL-4 is known to regulate T(H1) and T(H2) cell responsiveness primarily through the activation
A central role for CD95 (Fas) in T-cell reactivity after injury.: Surgery. 2000 Aug;128(2):159-64. Unique Identifier : AIDSLINE MED/20382824; Kell MR; Shelley O; Mannick JA; Guo Z; Lederer JA; Department of Surgery(Immunology), Brigham and Women's Hospital; and Harvard Medical School, Boston, MA 02115, USA.; BACKGROUND: Recent findings indicate that severe injury primes the immune system for an enhanced and lethal proinflammatory cytokine response against bacterial-derived superantigens. This study asked whether this response to injury involves the CD95 (Fas) signaling pathway. METHODS: To assess superantigen-mediated mor
Intrathymic alloantigen-mediated, tolerant, completely major histocompatibility complex-mismatched mouse hearts are specifically rejected by adoptively transferred anti-class I L(d+)-specific 2C cells.: Surgery. 2000 Aug;128(2):206-12. Unique Identifier : AIDSLINE MED/20382831; Otomo N; Motoyama K; Yu S; Shimizu Y; Margenthaler J; Tu F; Flye MW; Department of Surgery, Washington University School of Medicine,; St Louis, MO 63110, USA.; BACKGROUND: Tolerance to cardiac allografts can be induced in mice and rats by the injection of donor alloantigen into the thymus in combination with a CD4 T-cell-depleting antibody. CD8(+) cells in these animals are hyporesponsive to graft-specific alloantigens. Most of the CD8(+) T cells in the transgenic 2C mouse e
Mitral annular dynamics during rapid atrial pacing.: Surgery. 2000 Aug;128(2):361-7. Unique Identifier : AIDSLINE MED/20382855; Timek TA; Lai DT; Dagum P; Green GR; Glasson JR; Daughters GT; Ingels NB Jr; Miller DC; Department of Cardiovascular and Thoracic Surgery, Stanford; University School of Medicine, CA 94305-5247, USA.; INTRODUCTION: Ovine mitral annular area (MAA) reduction predominantly occurs before ventricular systole. We used the myocardial marker methods to investigate left atrial and MAA dynamics during rapid atrial pacing. METHODS: Seven sheep underwent implantation of 21 myocardial markers around the mitral annulus, the left
Nutritional status influences plasma fibrinogen concentration: evidence from the THUSA survey.: Thromb Res. 2000 Jun 1;98(5):383-94. Unique Identifier : AIDSLINE MED/20291372; James S; Vorster HH; Venter CS; Kruger HS; Nell TA; Veldman FJ; Ubbink JB; Department of Biological Sciences, University of North-West,; Mmabatho, South Africa.; Nutritional status and risk factors for chronic diseases, including plasma fibrinogen and its determinants, of Africans in the Northwest Province of South Africa , have been studied in a cross-sectional survey. A representative sample of 1854 apparently healthy African men and wo
Photochemical inactivation of bacteria and HIV in buffy-coat-derived platelet concentrates under conditions that preserve in vitro platelet function.: Vox Sang. 2000;78(4):209-16. Unique Identifier : AIDSLINE MED/20355219; Knutson F; Alfonso R; Dupuis K; Mayaudon V; Lin L; Corash L; Hogman CF; Department of Clinical Immunology and Transfusion Medicine,; University Hospital, Uppsala, Sweden. Folke.Knutson@KlinImm.uu.se; BACKGROUND AND OBJECTIVES: A photochemical process has been tested for the inactivation of viruses and bacteria in buffy-coat derived platelet concentrates (BC PCs). MATERIALS AND METHODS: BC PCs in 35% CPD plasma and 65% platelet-additive solution (PAS III) were exposed to photochemical treatment (PCT) with 150 micro
Minimization of chronic plasma viremia in rhesus macaques immunized with synthetic HIV-1 Tat peptides and infected with a chimeric simian/human immunodeficiency virus (SHIV33).: Vaccine. 2000 Jun 15;18(25):2789-95. Unique Identifier : AIDSLINE MED/20274199; Goldstein G; Manson K; Tribbick G; Smith R; Thymon L.L.C., Short Hills, NJ 07078, USA. gidgold@aol.com; HIV-1 Tat protein activates resting cells, rendering them permissive for viral replication. Replication of HIV-1 in vitro is enhanced by intercellular passage of Tat protein and inhibited by anti-Tat antibodies. Tat dependence of HIV-1 replication in vivo during acute, chronic asymptomatic and AIDS stages of infection
Injection with interleukin-4-secreting fibroblasts efficiently induces T helper type 2 cell-dominated immune response.: Vaccine. 2000 Jun 15;18(25):2832-7. Unique Identifier : AIDSLINE MED/20274205; Kim TS; Kim SH; Hwang SY; College of Pharmacy and Research Institute of Drug Development,; Chonnam National University, Kwangju, South Korea.; taekim@chonnam.ac.kr; To determine whether the paracrine secretion of interleukin-4 (IL-4) can efficiently induce T helper type 2 (Th2) cell-dominated immune response, BLK fibroblasts were stably transfected to secrete IL-4 (750 units/10(6) cells/48 h). Their effects on T helper cell-mediated immune response were investigated in ovalbumin
Possible association between cytomegalovirus infection and gastrointestinal bleeding in hemophiliac patients.: Acta Haematol. 2000;103(2):73-7. Unique Identifier : AIDSLINE MED/20298153; Nogueira E; Arruda VR; Bizzacchi JM; Costa FF; Ozelo MC; Rossi CL; Costa SC; Departamento de Clinica Medica, Faculdade de Ciencias; Medicas, Universidade Estadual de Campinas, Campinas, Brazil.; Cytomegalovirus ( CMV ) infection is of major concern in immunocompromised and immunosuppressed patients. Prior to the introduction of HIV-1 antibody screening and efficient virucidal processes to inactivate viruses, individuals with a factor VIII or factor IX def
Evidence of lymphocyte alveolitis by bronchoalveolar lavage in thalassemic patients with pulmonary dysfunction.: Acta Haematol. 2000;103(2):90-5. Unique Identifier : AIDSLINE MED/20298156; Filosa A; Esposito V; Meoli I; Baron I; Romano L; XXIX Pediatrics Department, Cardarelli Hospital, Naples, Italy.; filosatin.it; Pulmonary dysfunction represents one of the least studied complications in thalassemic patients. Probably, it is due to the absence of pulmonary symptoms. There are few works in the literature, and contradictory results have been published. The aim of this study was to define the spirometric pattern and the possible c
Type I and type II T cell profiles in chronic myelogenous leukemia.: Acta Haematol. 2000;103(2):96-101. Unique Identifier : AIDSLINE MED/20298157; Tsuda H; Yamasaki H; Division of Clinical Hematology and Immunology, Kumamoto City; Hospital, Kumamoto, Japan. tsudasan@wc4.so-net.ne.jp; T cell immunity is considered to play an important role in the control of cell growth in chronic myelogenous leukemia (CML) although information regarding the characteristics of T lymphocytes in CML patients is limited. Using flow cytometric analysis of intracellular cytokine expression at the single-cell level, we an
Phase angle from bioelectrical impedance analysis remains an independent predictive marker in HIV-infected patients in the era of highly active antiretroviral treatment.: Am J Clin Nutr. 2000 Aug;72(2):496-501. Unique Identifier : AIDSLINE MED/20380491; Schwenk A; Beisenherz A; Romer K; Kremer G; Salzberger B; Elia M; Klinik I fur Innere Medizin der Universitat zu Koln, Cologne,; Germany. a.schwenk@sghms.ac.uk; BACKGROUND: Highly active antiretroviral treatment (HAART) reduces the risk of wasting in HIV infection and may alter the prognostic weight of wasting. The phase angle from bioelectrical impedance analysis (BIA) can be interpreted as a surrogate marker for the catabolic reaction to chronic HIV infection and opportunis
Overnutrition and undernutrition as modifiers of metabolic processes in disease states.: Am J Clin Nutr. 2000 Aug;72(2 Suppl):533S-7S. Unique Identifier : AIDSLINE MED/20380500; Pi-Sunyer FX; Obesity Research Center, St Luke's-Roosevelt Hospital Center,; Columbia University, New York, NY 10025, USA. fxp1@columbia.edu; Both overnutrition and undernutrition affect energy metabolism, with overnutrition raising energy expenditure and undernutrition lowering it. Fever is a powerful stimulator of thermogenesis. In diseases such as cancer, AIDS, diabetes mellitus, and rheumatoid arthritis, whether energy expenditure is increased or decrea
Predictors of condom use in Mexican migrant laborers.: Am J Community Psychol. 2000 Apr;28(2):245-65. Unique Identifier : AIDSLINE MED/20295800; Organista KC; Organista PB; Bola JR; Garcia de Alba JE; Castillo Moran MA; School of Social Welfare, University of California, Berkeley; 94720, USA.; The purpose of this study was to explore predictors of condom use with occasional sex partners and regular sex partners, as well as carrying condoms in a new high-risk group for HIV infection, Mexican migrant laborers. This study extends previous findings by (1) exploring additional predictors not previously examined,
Didanosine-induced hepatitis [letter]: Am J Gastroenterol. 2000 Aug;95(8):2141-3. Unique Identifier : AIDSLINE MED/20405023; Ware AJ; Berggren RA; Taylor WE
Health-related quality of life in patients with human immunodeficiency virus infection in the United States: results from the HIV Cost and Services Utilization Study.: Am J Med. 2000 Jun 15;108(9):714-22. Unique Identifier : AIDSLINE MED/20401630; Hays RD; Cunningham WE; Sherbourne CD; Wilson IB; Wu AW; Cleary PD; McCaffrey DF; Fleishman JA; Crystal S; Collins R; Eggan F; Shapiro MF; Bozzette SA; University of California, Los Angeles, Department of General; Internal Medicine and Health Sciences Research, California; 90095-1736, USA. hays@rand.org; PURPOSE: To measure health-related quality of life among adult patients with human immunodeficiency virus (HIV) disease; to compare the health-related quality of life of adults with HIV with that of the general population and with patients with other chronic conditions; and to determine the associations of demographic
Acromegaly in a hemophilic patient infected with the hepatitis C and human immunodeficiency viruses [letter]: Am J Med. 2000 Jun 15;108(9):757-8. Unique Identifier : AIDSLINE MED/20401643; Schmid C; Meili E
Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases.: Analyst. 2000 Jun;125(6):1037-9. Unique Identifier : AIDSLINE MED/20388229; Svensson LA; Owens PK; Analytical Development, AstraZeneca R&D Molndal, Sweden.; Racemic mixtures of five acidic drugs have been successfully separated by supercritical fluid chromatography (SFC) using macrocyclic antibiotic chiral stationary phases (CSPs). A ristocetin A CSP has been prepared in-house and effectively applied in packed capillary SFC to separate the enantiomers of dichlorprop (R(
[HHV-8/KSHV. I - epidemiological and molecular aspects]: Ann Dermatol Venereol. 2000 May;127(5):528-31. Unique Identifier : AIDSLINE MED/20322875; Dupin N; Calvez V; Service de Dermato-Venereologie, Hopital Tarnier, Paris.
Epidermic necrolysis: advances in pathogenesis.: Ann Dermatol Venereol. 2000 May;127(5):546-7. Unique Identifier : AIDSLINE MED/20322878; Roujeau JC; Service de Dermatologie, Hopital Henri-Mondor, Universite Paris; XII, 94010 Creteil Cedex.
Expression and purification of recombinant HIV-1 tat protein using HIV-1-tat specific monoclonal antibodies.: Anticancer Res. 2000 Jul-Aug;20(4):2377-81. Unique Identifier : AIDSLINE MED/20409419; Demirhan I; Hofmann D; Chandra A; Hasselmayer O; Chandra P; Department of Molecular Biology (ZBC), Frankfurt University; Medical School, Germany.; We expressed tat protein from HIV-1 coding AA 1-67 (strain HIV-Bru) in the inducible vector pTrc 99A in E. coli. The tat coding region was cloned in the ATG site of the expression vector. A sequence coding for 15 AA was added at the 3 region as a molecular marker. After sonification, the tat protein was routinely dete
Inhibition of tat-mediated HIV-1-LTR transactivation and virus replication by sulfhydryl compounds with chelating properties.: Anticancer Res. 2000 Jul-Aug;20(4):2513-7. Unique Identifier : AIDSLINE MED/20409440; Demirhan I; Chandra A; Sarin PS; Hasselmayer O; Hofmann D; Chandra P; Gustav-Embden Center, Department of Molecular Biology, Frankfurt; University Medical School, Germany.; D-Penicillamine, a structural analog of cysteine, has the ability to chelate metal ions and reacts with cysteine. We have shown earlier that D-Penicillamin is a potential inhibitor of tat-mediated transactivation of HIV-1-LTR (14) and possesses anti-HIV-1 activity (23). Following this approach, we evaluated the anti-t
Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.: Anticancer Res. 2000 Jul-Aug;20(4):2525-36. Unique Identifier : AIDSLINE MED/20409442; Fukai T; Sakagami H; Toguchi M; Takayama F; Iwakura I; Atsumi T; Ueha T; Nakashima H; Nomura T; Faculty of Pharmaceutical Sciences, Toho University, Chiba,; Japan. fukai@phar.toho-u.ac.jp; A total of 150 chemically-defined natural and synthetic polyphenols (flavonoids, dibenzoylmethanes, dihydrostilbenes, dihydrophenanthrenes and 3-phenylchromen-4-ones), with molecular weights ranging from 224 to 824, were investigated for cytotoxic activity against normal, tumor and human immunodeficiency virus (HIV)-i
What is the role of activated Th1 cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration? [letter; comment]: Ann Neurol. 2000 Aug;48(2):271. Unique Identifier : AIDSLINE MED/20393580; Tanaka M; Tanaka K
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.: Antimicrob Agents Chemother. 2000 Jul;44(7):1783-8. Unique Identifier : AIDSLINE MED/20316787; Bazmi HZ; Hammond JL; Cavalcanti SC; Chu CK; Schinazi RF; Mellors JW; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pittsburgh,; Pennsylvania, USA.; Human immunodeficiency virus type 1 (HIV-1) isolates resistant to (-)-beta-D-dioxolane-guanosine (DXG), a potent and selective nucleoside analog HIV-1 reverse transcriptase (RT) inhibitor, were selected by serial passage of HIV-1(LAI) in increasing drug concentrations (maximum concentration, 30 microM). Two independen
A population pharmacokinetic analysis of nelfinavir mesylate in human immunodeficiency virus-infected patients enrolled in a phase III clinical trial.: Antimicrob Agents Chemother. 2000 Jul;44(7):1832-7. Unique Identifier : AIDSLINE MED/20316794; Jackson KA; Rosenbaum SE; Kerr BM; Pithavala YK; Yuen G; Dudley MN; Department of Applied Pharmaceutical Science, University of Rhode; Island, Kingston, Rhode Island, USA.; A population pharmacokinetic analysis was conducted on nelfinavir in patients infected with human immunodeficiency virus (HIV) who were enrolled in a phase III clinical trial. The data consisted of 509 plasma concentrations from 174 patients who received nelfinavir at a dose of 500 or 750 mg three times a day. The ana
Effect of zidovudine on the primary cytolytic T-lymphocyte response and T-cell effector function.: Antimicrob Agents Chemother. 2000 Jul;44(7):1900-5. Unique Identifier : AIDSLINE MED/20316807; Francke S; Orosz CG; Hayes KA; Mathes LE; Department of Veterinary Biosciences, College of Veterinary; Medicine, The Ohio State University, Columbus, Ohio 43210, USA.; Azidothymidine ( AZT ) and other nucleoside analogues, used to treat AIDS, can cause severe clinical side effects and are suspected of suppressing immune cell proliferation and effector immune cell function. The purpose of the present study was to quant
Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive thai patients and healthy volunteers.: Antimicrob Agents Chemother. 2000 Jul;44(7):1986-9. Unique Identifier : AIDSLINE MED/20316824; Wattanagoon Y; Na Bangchang K; Hoggard PG; Khoo SH; Gibbons SE; Phiboonbhanakit D; Karbwang J; Back DJ; Department of Clinical Tropical Medicine, Faculty of Tropical; Medicine, Mahidol University, Bangkok, Thailand.; We assessed the pharmacokinetics of zidovudine (ZDV) in plasma and intracellular ZDV phosphate anabolites in peripheral blood mononuclear cells in Thai human immunodeficiency virus (HIV) type 1-infected patients and healthy volunteers. The plasma ZDV area under the concentration-time curve from 0 to 6 h (AUC(0-6)) was
Mycobacterium avium grown in Acanthamoeba castellanii is protected from the effects of antimicrobials.: Antimicrob Agents Chemother. 2000 Jul;44(7):1990-4. Unique Identifier : AIDSLINE MED/20316825; Miltner EC; Bermudez LE; Kuzell Institute for Arthritis and Infectious Diseases,; California Pacific Medical Center Research Institute, San; Francisco, California, USA.; Mycobacterium avium is a common cause of systemic bacterial infection in patients with AIDS. Infection with M. avium has been linked to bacterial colonization of domestic water supplies and commonly occurs through the gastrointestinal tract. Acanthamoeba castellanii, a waterborne protozoan, may serve as an environment
Targeted cleavage of HIV-1 coreceptor-CXCR-4 by RNA-cleaving DNA-enzyme: inhibition of coreceptor function.: Antiviral Res. 2000 May;46(2):125-34. Unique Identifier : AIDSLINE MED/20314177; Basu S; Sriram B; Goila R; Banerjea AC; Laboratory of Virology, National Institute of Immunology, Aruna; Asaf Ali Marg, -110067, New Delhi, India.; HIV needs the chemokine receptors (HIV-1 coreceptors) to initiate infection and gain entry into a susceptible cell. CCR5 receptor is used by macrophage tropic viruses to establish infection, and CXCR-4 is used by T lymphocyte tropic virus which are usually found at the terminal stages of the disease. These chemokine r
Current research on influenza and other respiratory viruses: II international symposium.: Antiviral Res. 2000 May;46(2):91-124. Unique Identifier : AIDSLINE MED/20314176; Munoz FM; Galasso GJ; Gwaltney JM Jr; Hayden FG; Murphy B; Webster R; Wright P; Couch RB; Department of Molecular Virology and Microbiology, Room 221-D, 1; Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA.; florm@bcm.tmc.edu
Tracking immunoglobulin variable-gene expression in HIV infection.: Appl Biochem Biotechnol. 2000 Jan-Mar;83(1-3):13-28; discussion 28-9, 145-53. Unique Identifier : AIDSLINE MED/20285222; Zouali M; Institut National de la Sante et de la Recherche Medicale; (INSERM), Paris, France.; B-cell superantigens (SAgs) interact with normal human nonimmune immunoglobulins (Igs) independently of the light-chain isotype, and activate a large proportion of the B-cell repertoire. Recently, the major envelope protein of human immunodeficiency virus 1 (HIV-1), gp120, was found to exhibit SAg-like properties for
How and why 41S-2 antibody subunits acquire the ability to catalyze decomposition of the conserved sequence of gp41 of HIV-1.: Appl Biochem Biotechnol. 2000 Jan-Mar;83(1-3):209-19; discussion 219-20, 297-313. Unique Identifier : AIDSLINE MED/20285237; Hifumi E; Okamoto Y; Uda T; School of Biosciences, Hiroshima Prefectural University,; Shoubara, Japan.; It has become well known that antibodies obtained by immunization with the ground state of peptides can display proteolytic activity. Our antibody light chain produced by immunization with the peptide RGPDRPEGIEEEGGERDRD, a highly conserved sequence in envelope gp41 of HIV-1 showed the ability to cleave this peptide.
Multifunctional antigens of A. fumigatus and specific antibodies.: Appl Biochem Biotechnol. 2000 Jan-Mar;83(1-3):271-83; discussion 283-6, 297-313. Unique Identifier : AIDSLINE MED/20285242; Purkayastha S; Madan T; Shah A; Krishnamurthy HG; Sarma PU; Centre for Biochemical Technology, Delhi, India.; The majority of Aspergillus-induced infections in man are caused by the pathogenic fungus A. fumigatus, which secretes biologically and immunologically active glycosylated and nonglycosylated proteins. The complexity in the antigenic structure of A. fumigatus and the varying host immune responses lead to a wide spectr
Natural catalytic immunity is not restricted to autoantigenic substrates: identification of a human immunodeficiency virus gp 120-cleaving antibody light chain.: Appl Biochem Biotechnol. 2000 Jan-Mar;83(1-3):71-82; discussion 82-4, 145-53. Unique Identifier : AIDSLINE MED/20285226; Paul S; Kalaga RS; Gololobov G; Brenneman D; Department of Pathology, University of Texas Medical School,; Houston 77030, USA.; The autoimmune repertoire is well known from previous studies to be capable of producing catalytic antibodies directed to self-antigens. In the present study, we explored the ability of 26 monoclonal light chains (L chains) from multiple myeloma patients to cleave radiolabeled gp120, a foreign protein. One L chain wit
Curly hair and lipodystrophy as a result of highly active antiretroviral treatment? [letter]: Arch Dermatol. 2000 Aug;136(8):1064-5. Unique Identifier : AIDSLINE MED/20384139; Colebunders R; Bottieau E; de Mey I
Topical cidofovir: a novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1.: Arch Dermatol. 2000 Aug;136(8):983-5. Unique Identifier : AIDSLINE MED/20384120; Toro JR; Wood LV; Patel NK; Turner ML; Dermatology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892-1908, USA.; torojo@exchange.nih.gov.
Report of a false-positive HIV test result and the potential use of additional tests in establishing HIV serostatus.: Arch Intern Med. 2000 Aug 14-28;160(15):2386-8. Unique Identifier : AIDSLINE MED/20386827; Mylonakis E; Paliou M; Greenbough TC; Flaningan TP; Letvin NL; Rich JD; Infectious Disease Division, Massachussets General Hospital,; Boston, MA 02114-2696. emylonakis@partners.org; Considering the lifelong implications of a positive human immunodeficiency virus (HIV) test result, physicians should be aware of the limitations of tests for HIV. A 43-year-old man had a reactive enzyme-linked immunosorbent assay and an indeterminate result on Western blot analysis. The results of subsequent enzyme-l
Pericardial effusion in acquired immunodeficiency disease [letter; comment]: Arch Intern Med. 2000 Aug 14-28;160(15):2397-8. Unique Identifier : AIDSLINE MED/20386835; Chen Y; Brennessel D; Johnson M; Rosner F
Human T-lymphotropic virus 1 adult T-cell lymphoma with Giardia and Strongyloides parasitism.: Arch Pathol Lab Med. 2000 Aug;124(8):1241. Unique Identifier : AIDSLINE MED/20382632; Isotalo PA; Toye B; Eidus L; Department of Pathology and Laboratory Medicine, University of; Ottawa, Ottawa, Ontario, Canada.
Human immunodeficiency virus reverse transcriptase base misincorporations can promote strand transfer.: Arch Virol. 2000;145(6):1117-31. Unique Identifier : AIDSLINE MED/20403262; Diaz L; Cristofaro JV; DeStefano JJ; Department of Cell Biology and Molecular Genetics, University of; Maryland College Park, 20742, USA.; A system to determine if HIV-reverse transcriptase (RT) base misincorporations can promote strand transfer was constructed. A donor RNA, on which RT-directed DNA synthesis was initiated, shared homology over a 119 base internal region with an acceptor RNA, to which DNAs initiated on the donor could transfer. Products
Mycobacterium avium complex spinal epidural abscess in an HIV patient.: Australas Radiol. 1999 Nov;43(4):554-7. Unique Identifier : AIDSLINE MED/20360439; Rotstein AH; Stuckey SL; Magnetic Resonance Imaging Unit, Alfred Hospital, Prahran,; Victoria, Australia. rotstein@netspace.net.au; Although Mycobacterium avium complex (MAC) is the most common opportunistic bacterial infection in AIDS patients, epidural involvement is rare. A case of MAC spinal epidural abscess without vertebral osteomyelitis, that was continuous with presacral and bilateral piriformis muscle inflammation, is reported.
Solubilization of the chemokine receptor CXCR4.: Biochem Biophys Res Commun. 2000 Jul 21;274(1):153-6. Unique Identifier : AIDSLINE MED/20365843; Staudinger R; Bandres JC; Department of Pathology, Department of Neurology, Department of; Medicine, New York University, School of Medicine, 423 East 23rd; Street, New York, New York 10010, USA.; The chemokine receptor CXCR4 was solubilized from the human T-cell line CEM by using the detergent n-dodecyl-beta-maltoside (DDM) and cholesteryl hemisuccinate ester (CHS). Binding studies with (125)I-SDF-1alpha revealed a dissociation constant of 5.33 nM and a receptor density (B(max)) of 2.68 pmol/mg in CEM membrane
Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor.: Biochem Biophys Res Commun. 2000 Jul 21;274(1):212-5. Unique Identifier : AIDSLINE MED/20365852; Pandey V; Bolsover SR; Department of Physiology, University College London, Gower; Street, London, WC1E 6BT, United Kingdom.; Primary rat hippocampal neurones show pronounced elevations of intracellular calcium within minutes of exposure to the HIV coat protein gp120. Culture of hippocampal neurones with gp120 causes significant neurotoxicity. We find that the peptide VSLSYRCPCRFF, a competitive inhibitor of the CXCR4 chemokine receptor, mar
Genetic characterization of incident HIV type 1 subtype E and B strains from a prospective cohort of injecting drug users in Bangkok, Thailand.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):699-707. Unique Identifier : AIDSLINE +; Subbarao S; Vanichseni S; Hu DJ; Kitayaporn D; Choopanya K; Raktham S; Young NL; Wasi C; Sutthent R; Luo CC; Ramos A; Mastro TD; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA. sfs2@cdc.gov; We obtained specimens from 128 HIV-1 seroconverters identified from 1995 through 1998 in a prospective cohort study of 1,209 HIV-negative injecting drug users (IDUs) in Bangkok, Thailand . Epidemiologic data indicated that parenteral transmission accounted for nearly all infection
Deletion of the p16INK4A gene in ex vivo acute adult T cell lymphoma/leukemia cells and methylation of the p16INK4A promoter in HTLV type I-infected T cell lines.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):709-13. Unique Identifier : AIDSLINE MED/20284710; Trovato R; Cereseto A; Takemoto S; Gessain A; Watanabe T; Waldmann T; Franchini G; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; The stoichiometry of the p16INK4A and p15INK4B proteins bound to the cyclin D-CDK4/6 complex regulates the entry of cells into the G1 phase of the cell cycle. Thus, their level of expression is essential in maintaining regulated cell growth. In several tumors, deletion of these genes has been reported and, more recent
HTLV-I/HTLV-II coinfection in an AIDS patient from Sao Paulo, Brazil.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):715-9. Unique Identifier : AIDSLINE MED/20284711; Caterino-de-Araujo A; Favero A; de los Santos-Fortuna E; Suleiman J; Chieco-Bianchi L; Calabro ML; Department of Oncology and Surgical Sciences, University of; Padua, Italy.; A serological survey for HTLV infection identified an AIDS patient with HTLV-I/HTLV-II dual seroreactivity. Two further sequential blood samples were collected (samples A and B) for PCR, restriction fragment length polymorphism (RFLP), and sequence analyses of HTLV-I and HTLV-II strains. PCR analyses confirmed dual in
Rapid identification of all known retroviral reverse transcriptase sequences with a novel versatile detection assay.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):721-9. Unique Identifier : AIDSLINE MED/20284712; Seifarth W; Krause U; Hohenadl C; Baust C; Hehlmann R; Leib-Mosch C; Medical Clinic III, Faculty of Clinical Medicine Mannheim,; University of Heidelberg, Germany. seifarth@rumms.uni-mannheim.de; We have developed a highly sensitive, universal assay that allows detection as well as identification of all known retroviral reverse transcriptase (RT)-related nucleic acids in a biological sample by a single two-step experiment. The assay combines polymerase chain reaction (PCR) and reverse dot-blot hybridization (R
Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):731-40. Unique Identifier : AIDSLINE GENBANK/AF156963; Voisset C; Bouton O; Bedin F; Duret L; Mandrand B; Mallet F; Paranhos-Baccala G; Unite Mixte 103 CNRS-bioMerieux, Ecole Normale Superieure de; Lyon, France.; Some genomic elements of the multicopy HERV-W endogenous retroviral family have been previously identified in databases. One of them, located on chromosome 7, contains a single complete open reading frame (ORF) putatively encoding an envelope protein. We have experimentally investigated the genomic complexity and codi
Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):741-9. Unique Identifier : AIDSLINE MED/20284714; Rizzuto C; Sodroski J; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.; A previous study implicated a conserved surface of the human immunodeficiency virus (HIV-1) gp120 exterior envelope glycoprotein in binding the CCR5 viral coreceptor (Rizzuto C, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, and Sodroski J: Science 1998;280:1949-1953). Additional mutagenesis indicates th
In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):751-63. Unique Identifier : AIDSLINE MED/20284715; Villinger F; Bucur S; Chikkala NF; Brar SS; Bostik P; Mayne AE; Adams J; Lee ME; Novembre FJ; Gately MK; Ansari AA; Hillyer CD; Department of Pathology and Laboratory Medicine, School of; Medicine, Emory University, Atlanta, Georgia 30322, USA.; fvillin@emory.edu; The in vitro proliferative responses of macaque peripheral blood mononuclear cells (PBMCs) to IL-12 appeared similar before and early after SIV infection, whereas macaque PBMCs sampled during symptomatic stages of SIV infection showed markedly decreased responses. IL-12 was administered to SIVmac239-infected rhesus ma
Higher western blot immunoreactivity of glycoprotein 120 from R5 HIV type 1 isolates compared with X4 and X4R5 isolates.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):765-75. Unique Identifier : AIDSLINE MED/20284716; Lee MK; Martin MA; Cho MW; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda,; Maryland 20892, USA.; The envelope glycoprotein of human immunodeficiency virus 1 (HIV-1) plays important roles in viral life cycle and pathogenesis. Understanding the immune responses the protein elicits during the course of a viral infection in patients is important in designing an effective vaccine candidate against the virus or for bet
Nef modulation of HIV type 1 gene expression and cytopathicity in tissues of HIV transgenic mice.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):777-90. Unique Identifier : AIDSLINE MED/20284717; Dickie P; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada. peter.dickie@ualberta.ca; Transgenic mice bearing HIV-1 proviral DNA deleted in the gag/pol region (HIVd1443 mice) model a chronic, nonproductive form of viral gene expression in various cell types including macrophages. They display a disease phenotype that includes HIV-associated nephropathy (HIVAN), congenital cataracts, papillomatosis, and
Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):791-800. Unique Identifier : AIDSLINE MED/20284718; Silvera P; Racz P; Racz K; Bischofberger N; Crabbs C; Yalley-Ogunro J; Greenhouse J; Jiang JB; Lewis MG; Henry Jackson Foundation, Rockville, Maryland 20850, USA.; silvera@sri.org; In this study we compared the effect of postexposure treatment of the acyclic nucleoside analogs 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) and 9-(2-phosphonylmethoxypropyl)-adenine (PMPA) on the kinetics of viral load in the blood and lymph nodes of rhesus macaques chronically infected with SIVmac251 for 18 weeks. T
Diversity of envelope glycoprotein from human immunodeficiency virus type 1 of recent seroconverters in Thailand.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):801-5. Unique Identifier : AIDSLINE MED/20284719; McCutchan FE; Viputtigul K; de Souza MS; Carr JK; Markowitz LE; Buapunth P; McNeil JG; Robb ML; Nitayaphan S; Birx DL; Brown AE; Walter Reed Army Institute of Research, Rockville, Maryland; 20850, USA.; The envelope-coding sequence of human immunodeficiency virus type 1 (HIV-1) was determined for 11 Thai seroconverters between 1995 and 1996. On the basis of the env sequences, all subjects were infected with HIV subtype E. Compared with the interpatient protein diversity among HIV-1 Thai reference sequences from 1990
Analysis of HIV type 1 protease and reverse transcriptase in antiretroviral drug-naive Ugandan adults.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):807-13. Unique Identifier : AIDSLINE MED/20284720; Becker-Pergola G; Kataaha P; Johnston-Dow L; Fung S; Jackson JB; Eshleman SH; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, Maryland 21205, USA.; We analyzed plasma HIV-1 from 27 antiretroviral drug-naive Ugandan adults. Previous subtype analysis of env and gag sequences from these samples identified subtypes A, C, D, and recombinant HIV-1. Sequences of HIV-1 protease and reverse transcriptase (RT) were obtained with a commercial HIV-1 genotyping system. Subtyp
Genetic characterization and phylogenetic analysis of HIV-1 subtype C from Uganda.: AIDS Res Hum Retroviruses. 2000 May 20;16(8):815-9. Unique Identifier : AIDSLINE GENBANK/AF206071; Downing R; Pieniazek D; Hu DJ; Biryahwaho B; Fridlund C; Rayfield MA; Sempala SD; Lal RB; Uganda Virus Research Institute, Entebbe.; To better understand the emergence of subtype C and its potential impact on vaccine efforts in Uganda , we have characterized subtype C sequences from Uganda (n = 13), Zimbabwe (n = 11), Mozambique (n =
Mutations in the reverse transcriptase gene of HIV type 1 from subjects after stavudine-didanosine dual therapy [letter]: AIDS Res Hum Retroviruses. 2000 May 20;16(8):821-3. Unique Identifier : AIDSLINE MED/20284722; Monno L; Appice A; Scarabaggio T; Di Stefano M; Pastore G; Angarano G
The functional role of class II-associated invariant chain peptide (CLIP) in its ability to variably modulate immune responses.: Int Immunol. 2000 Jun;12(6):757-65. Unique Identifier : AIDSLINE MED/20298415; Chaturvedi P; Hengeveld R; Zechel MA; Lee-Chan E; Singh B; Department of Microbiology and Immunology, and John P. Robarts; Research Institute, University of Western Ontario, London,; Ontario N6A 5C1, Canada.; During the process of class II MHC assembly and cell surface expression, the class II-associated invariant chain peptide (CLIP) is removed from the peptide-binding groove of MHC, a task mediated by H-2M. This allows binding and presentation of peptide epitopes. We have previously shown that exogenously added CLIP inte
Regulation of TCR-induced IFN-gamma release from islet-reactive non-obese diabetic CD8(+) T cells by prostaglandin E(2) receptor signaling.: Int Immunol. 2000 Jun;12(6):851-60. Unique Identifier : AIDSLINE MED/20298425; Ganapathy V; Gurlo T; Jarstadmarken HO; von Grafenstein H; School of Pharmacy, University of Southern California, 1985 Zonal; Avenue, Los Angeles, CA 90033, USA.; Prostaglandins (PG) are released during tissue injury and inflammation, and inhibit immune responses at many points. PG may be one of several factors that protect not only against injury-induced, but also spontaneous, organ-specific autoimmune disease. Here we show that the production of PGE(2), normally produced at a
Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4(+) and CD8(+) T lymphocytes is ATM-independent.: Unique Identifier : AIDSLINE MED/20298432; Rivero-Carmena M; Porras O; Pelaez B; Pacheco-Castro A; Gatti RA; Regueiro JR; In the genetic disorder ataxia telangiectasia (AT), humoral (B) and cellular (T) immunological abnormalities are frequently observed. As a consequence, AT patients are predisposed to life-threatening sinopulmonary infections. The pathogenic mechanisms remain unknown, but a role for ATM in signal transduction from memb
T(h)1 transmigration anergy: a new concept of endothelial cell-T cell regulatory interaction.: Int Immunol. 2000 Jun;12(6):937-48. Unique Identifier : AIDSLINE MED/20298433; Kawai T; Seki M; Watanabe H; Eastcott JW; Smith DJ; Taubman MA; Department of Immunology, The Forsyth Institute, 140 Fenway,; Boston, MA 02115, USA.; Stimulation of endothelial cells (EC) with IFN-gamma generates selective enhancement of T(h)1 cell transmigration and induction of MHC class II expression on EC. In the present study, we tested whether antigen presentation by EC could influence transmigrating T cells in an in vitro system. Bacterial antigen presentati
Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis.: Int Immunol. 2000 Jul;12(7):1005-13. Unique Identifier : AIDSLINE MED/20340796; Borthwick NJ; Lowdell M; Salmon M; Akbar AN; Departments of Clinical Immunology, Royal Free and University; College Hospital Medical Schools, London NW3 2PF, UK.; CD8(+)CD28(-) T cells are selectively expanded during viral infections, indicating their importance in anti-viral immune responses. Since little is known about the differentiation of CD8(+)CD28(-) cells, we investigated the generation, function and survival characteristics of this subset. In healthy individuals CD8(+)
Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus.: Int Immunol. 2000 Jul;12(7):1035-40. Unique Identifier : AIDSLINE MED/20340799; Bhandoola A; Kithiganahalli B; Granger L; Singer A; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA.; CD4(+) T cells are generally specialized to function as helper cells and CD8(+) T cells are generally specialized to function as cytotoxic effector cells. To explain how such concordance is achieved between co-receptor expression and immune function, we considered two possibilities. In one case, immature CD4(+)CD8(+)
Novel molecular mechanisms of dendritic cell-induced T cell activation.: Int Immunol. 2000 Jul;12(7):1051-61. Unique Identifier : AIDSLINE MED/20340801; Woodhead VE; Stonehouse TJ; Binks MH; Speidel K; Fox DA; Gaya A; Hardie D; Henniker AJ; Horejsi V; Sagawa K; Skubitz KM; Taskov H; Todd RF 3rd; van Agthoven A; Katz DR; Chain BM; Department of Immunology, Windeyer Institute of Medical Sciences,; UCL Medical School, 46 Cleveland Street, London W1P 6DB, UK.; In this study we have re-examined the molecular mechanisms involved in activation of T cells by dendritic cells (DC). Human peripheral blood DC (PBDC) were derived by 2 h adhesion followed by 7 day culture in a combination of granulocyte macrophage colony stimulating factor and IL-4, and depletion of residual T and B
Screening for CMV retinitis using chromatic discrimination thresholds and achromatic contrast sensitivity.: Unique Identifier : AIDSLINE MED/20366015 P; Newsom RS; Ong GL; Jackson TL; Coldrick I
Severe intraocular inflammation after a change of HAART [letter]: Br J Ophthalmol. 2000 Aug;84(8):933-4. Unique Identifier : AIDSLINE MED/20426844; Jackson TL; Meacock W; Youle M; Graham EM
A mechanism for plus-strand transfer enhancement by the HIV-1 nucleocapsid protein during reverse transcription.: Biochemistry. 2000 Aug 8;39(31):9084-91. Unique Identifier : AIDSLINE PDB/1EN1; Johnson PE; Turner RB; Wu ZR; Hairston L; Guo J; Levin JG; Summers MF; Howard Hughes Medical Institute and Department of Chemistry and; Biochemistry, University of Maryland Baltimore County, 21250,; USA.; The HIV-1 nucleocapsid protein (NC) functions as a nucleic acid chaperone during the plus-strand transfer step in reverse transcription by facilitating annealing of the primer binding site (PBS) sequence in the short plus-strand strong-stop DNA fragment [(+) SSDNA] to a complementary site located near the 3 end of th
Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy.: Biochemistry. 2000 Aug 8;39(31):9275-84. Unique Identifier : AIDSLINE MED/20384213; Deprez E; Tauc P; Leh H; Mouscadet JF; Auclair C; Brochon JC; Laboratoire de Biotechnologies et Pharmacologie Genetique; Appliquee (UMR-CNRS 8532), Ecole Normale Superieure (ENS) de; Cachan, Cachan Cedex, France.; Self-assembly properties of HIV-1 integrase were investigated by time-resolved fluorescence anisotropy using tryptophanyl residues as a probe. From simulation analyses, we show that suitable photon counting leads to an accurate determination of long rotational correlation times in the range of 20-80 ns, permitting the
Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase.: Biochemistry. 2000 Aug 8;39(31):9285-94. Unique Identifier : AIDSLINE MED/20384214; Leh H; Brodin P; Bischerour J; Deprez E; Tauc P; Brochon JC; LeCam E; Coulaud D; Auclair C; Mouscadet JF; Laboratoire de Physicochimie et de Pharmacologie des; Macromolecules Biologiques (UMR-CNRS 8532), Villejuif Cedex,; France.; The relationship between Mg(2+)-dependent activity and the self-assembly state of HIV-1 integrase was investigated using different protein preparations. The first preparations, IN(CHAPS) and IN(dial), were purified in the presence of detergent, but in the case of IN(dial), the detergent was removed during a final dial
Proceedings of the 4th International AIDS Impact Conference. 15-18 July 1999. Ottawa, Canada.: AIDS Care. 2000 Jun;12(3):253-364. Unique Identifier : AIDSLINE MED/20430967
Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG).: AIDS Care. 2000 Jun;12(3):255-66. Unique Identifier : AIDSLINE MED/20383336; Chesney MA; Ickovics JR; Chambers DB; Gifford AL; Neidig J; Zwickl B; Wu AW; Department of Medicine, University of California, San Francisco; 94105, USA. mchesney@psg.ucsf.edu; This paper describes the AACTG Adherence Instruments, which are comprised of two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antir
AIDS education for gay men: towards a more cognitive approach.: AIDS Care. 2000 Jun;12(3):267-72. Unique Identifier : AIDSLINE MED/20383337; Gold RS; School of Psychology, Deakin University, Victoria, Australia.; rongold@deakin.edu.au; An approach to AIDS education is presented that focuses on the thinking processes which accompany gay men s decisions to engage in high-risk sex. It is proposed that: (1) at the time they are deciding to have high-risk sex, gay men generally engage in an internal dialogue that justifies this decision to themselves;
The role of theory in HIV prevention.: AIDS Care. 2000 Jun;12(3):273-8. Unique Identifier : AIDSLINE MED/20383338; Fishbein M; Public Policy Center, Annenberg School for Communication; University of Pennsylvania, Philadelphia, USA.; mfishbein@asc.upenn.edu; There is growing evidence that well designed, targeted, theory-based behaviour change interventions can be effective in reducing the spread of HIV. Although each behaviour is unique, there are only a limited number of theoretical variables that serve as the determinants of any given behaviour. Understanding these vari
Sexual dysfunction in gay and bisexual men with HIV infection: evaluation, treatment and implications.: AIDS Care. 2000 Jun;12(3):279-86. Unique Identifier : AIDSLINE MED/20383339; Catalan J; Meadows J; Division of Neurosciences and Psychological Medicine, Imperial; College, University of London, UK. j.catalan@ic.ac.uk; Sexual dysfunction problems are common in people with HIV infection, but their relevance has been recently highlighted in response to the increased survival shown by many individuals with HIV, and the publicity surrounding the development of new treatments for male sexual dysfunction. Thirty-four gay/bisexual men with
Do gay men discuss HIV risk reduction with their GP?: AIDS Care. 2000 Jun;12(3):287-90. Unique Identifier : AIDSLINE MED/20383340; Elford J; Bolding G; Maguire M; Sherr L; Department of Primary Care and Population Sciences and Royal Free; Centre for HIV Medicine, London, UK. elford@rfhsm.ac.uk; In September/October 1997, 1,004 gay men using one of five gyms in central London completed a confidential anonymous questionnaire which included items on sexual as well as steroid-related injecting behaviour and whether they had ever discussed these behaviours with friends, sexual partners or a general practitioner (
Stressors and strengths among women living with HIV/AIDS in New York City.: AIDS Care. 2000 Jun;12(3):291-7. Unique Identifier : AIDSLINE MED/20383341; Simoni JM; Cooperman NA; Yeshiva University, Bronx, NY 10461-1602, USA.; jsimoni@aecom.yu.edu; We conducted face-to-face interviews with a non-probability sample of 373 women living with HIV/AIDS in New York City. Most were indigent African-Americans and Latinas (M age = 39.61 years). Participants reported considerable stressors. For example, 59% (n = 221) had been sexually abused and 69% (n = 258) physically a
HIV as identity, experience or career.: AIDS Care. 2000 Jun;12(3):299-306. Unique Identifier : AIDSLINE MED/20383342; Bartos M; McDonald K; Australian Research Centre in Sex, Health and Society, Melbourne,; Victoria, Australia. M.bartos@latrobe.edu.au; Issues of treatment compliance and the relationship between treatments, optimism and sexual practice are best understood when living with HIV is conceptualized as a dynamic process requiring individuals to work on their subjectivity. In an interview study of 76 people living with HIV/AIDS in
Consent and antenatal HIV testing: the limits of choice and issues of consent in HIV and AIDS.: AIDS Care. 2000 Jun;12(3):307-12. Unique Identifier : AIDSLINE MED/20383343; Sherr L; Bergenstrom A; Hudson CN; Department of Primary Care and Population Science Royal Free and; University College Medical School, London, UK. lsherr@rphsm.ac.uk; The mood of nihilism that affected HIV is now changing. The availability of new therapies allows for cautious optimism--especially in relation to mother-to-child transmission of HIV and preventative interventions. This has prompted a widespread policy shift towards HIV testing in pregnancy. In this context, informed c
First injection and current risk factors for HIV among new and long-term injection drug users.: AIDS Care. 2000 Jun;12(3):313-20. Unique Identifier : AIDSLINE MED/20383344; Chitwood DD; Sanchez J; Comerford M; Page JB; McBride DC; Kitner KR; Department of Sociology, University of Miami, Coral Gables, FL; 33146-0719, USA. dchitwood@miami.ed; The purpose of this paper is to estimate HIV seroprevalence and to examine the injection and sexual risk behaviours of a cohort of active new heroin injectors who have initiated injection within the past four years and to compare their risk behaviours with those of long-term heroin injectors who initiated injection pr
Cost-effectiveness of an HIV risk reduction intervention for adults with severe mental illness.: AIDS Care. 2000 Jun;12(3):321-32. Unique Identifier : AIDSLINE MED/20383345; Johnson-Masotti AP; Pinkerton SD; Kelly JA; Stevenson LY; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53202, USA. ajohnson@mcw.edu; Small-group HIV prevention interventions that focus on individual behavioural change have been shown to be especially effective in reducing HIV risk among persons with severe mental illness. Because economic resources to fund HIV prevention efforts are limited, health departments, community planning groups and other k
The changing pattern of mental health problems in HIV infection: the view from London, UK.: AIDS Care. 2000 Jun;12(3):333-41. Unique Identifier : AIDSLINE MED/20383346; Catalan J; Meadows J; Douzenis A; Imperial College, University of London, UK. j.catalan@ic.ac.uk; As we end the second decade with AIDS, profound changes in our understanding of its aetiology, mechanism of disease and its treatment have led to significant improvements in survival, disease progression and quality of life for those individuals with HIV infection who are fortunate enough to have access to health care
Gender differences in behavioural and psychosocial predictors of HIV testing and return for test results in a high-risk population.: AIDS Care. 2000 Jun;12(3):343-56. Unique Identifier : AIDSLINE MED/20383347; Stein JA; Nyamathi A; Department of Psychology, University of California, Los Angeles; 90095-1563, USA. jastein@ucla.edu; We assessed gender differences in psychosocial and behavioural predictors of HIV testing and returning for results in a high-risk sample of 1,049 predominately minority, impoverished, homeless and/or drug-abusing women (n = 621) and men (n = 428). Predictors included latent variables representing injection drug use, s
Stage of change versus an integrated psychosocial theory as a basis for developing effective behaviour change interventions. The Project RESPECT Study Group.: AIDS Care. 2000 Jun;12(3):357-64. Unique Identifier : AIDSLINE MED/20383348; Malotte CK; Jarvis B; Fishbein M; Kamb M; Iatesta M; Hoxworth T; Zenilman J; Bolan G; Health Science Department,California State University, Long Beach; 90815, USA.; According to the Stages of Change (SOC) model, behavioural change involves a process of movement from precontemplation (no intention to change), to contemplation (some intention to change, but no behaviour), to preparation (intention to change and early inconsistent behavioural attempts to change), to action (consiste
Clinical utility of testing human immunodeficiency virus for drug resistance.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S117-22. Unique Identifier : AIDSLINE MED/20318448; Harrigan PR; Cote HC; British Columbia Centre for Excellence in HIV/AIDS, Vancouver,; BC, V6Z 1Y6, Canada. lab@hivnet.ubc.ca; Human immunodeficiency virus (HIV) type 1 drug-resistance testing is quickly moving from the research laboratory to the clinic as data defining its utility as a prognostic indicator of response to therapy become available. In July 1998, a panel of the International AIDS Society-USA did not recommend the widespread app
Using pharmacokinetics to optimize antiretroviral drug-drug interactions in the treatment of human immunodeficiency virus infection.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S123-9. Unique Identifier : AIDSLINE MED/20318449; Gerber JG; Division of Clinical Pharmacology and Toxicology and Division of; Infectious Diseases, University of Colorado Health Sciences; Center, Denver, CO 80262, USA.; Better understanding of the pharmacokinetics of antiretroviral drugs has resulted in the design of combination therapies for the treatment of human immunodeficiency virus (HIV) infection. This has improved the bioavailability and prolonged the plasma half-life of some of the drugs, resulting in enhanced antiviral acti
Initial therapy with protease inhibitor-sparing regimens: evaluation of nevirapine and delavirdine.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S130-4. Unique Identifier : AIDSLINE MED/20318450; Conway B; Department of Pharmacology and Therapeutics, University of; British Columbia, Vancouver, BC, V6Z 1Y8, Canada.; bconway@interchange.ubc.ca.; We have compared the results (on-treatment analyses) of 2 randomized clinical trials of protease inhibitor-sparing regimens in drug-naive patients. In the INCAS ( Italy , Netherlands , Canada ,
HIV protease inhibitor-related lipodystrophy syndrome.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S135-42. Unique Identifier : AIDSLINE MED/20318451; Carr A; HIV Medicine Unit, St. Vincent's Hospital, Sydney, Australia.; Human immunodeficiency virus (HIV) protease inhibitor (PI) therapy is frequently associated with a syndrome increasingly referred to as lipodystrophy syndrome, which is characterized by peripheral lipoatrophy, fat accumulation within the abdomen, in the breasts of women, and over the cervical vertebrae ( buffalo hump
Role of hydroxyurea in treatment of disease due to human immunodeficiency virus infection.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S143-50. Unique Identifier : AIDSLINE MED/20318452; Zala C; Rouleau D; Montaner JS; Fundacion Huesped, 1202 Buenos Aires, Argentina.; czala@teletel.com. ar; The potential role of hydroxyurea in the treatment of human immunodeficiency virus (HIV) infection was first supported by in vitro experiments that demonstrated control of viral production in activated and resting T cells. More recently, controlled clinical trials demonstrated that the addition of hydroxyurea to nucle
Pharmacodynamics of human immunodeficiency virus type 1 protease inhibitors.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S151-9. Unique Identifier : AIDSLINE MED/20318453; Acosta EP; Kakuda TN; Brundage RC; Anderson PL; Fletcher CV; College of Pharmacy, Department of Experimental and Clinical; Pharmacology, University of Minnesota Academic Health Sciences; Center, Minneapolis, MN 55455, USA. fletc001@tc.umn.edu.; Many factors are involved in the success or failure of antiretroviral therapy. Recent data suggest that there are significant differences in drug absorption and disposition for the protease inhibitor class of antiretroviral drugs, and relationships between plasma concentrations and their antiviral effect have been des
HIV-1 protease inhibitors.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S160-70. Unique Identifier : AIDSLINE MED/20318454; Eron JJ Jr; Infectious Diseases Division, University of North Carolina at; Chapel Hill, Chapel Hill, NC 27599-7030, USA. jeron@med.unc.edu.; Treatment of human immunodeficiency virus type 1 (HIV-1) infection with regimens that include protease inhibitors (PIs) has contributed to marked improvements in HIV-related disease progression and mortality. Five PIs are approved by the US Food and Drug Administrat
Factors affecting adherence to antiretroviral therapy.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S171-6. Unique Identifier : AIDSLINE MED/20318455; Chesney MA; School of Medicine, University of California San Francisco, San; Francisco, CA 94105, USA. mchesney@psg.ucsf.edu.; In both clinical trials and clinical practice, nonadherence to medications is widespread among patients with chronic diseases. The shift to combination therapies for treating human immunodeficiency virus (HIV)-infected individuals has increased adherence challenges for both patients and health-care providers. Estimate
Determinants of virological response to antiretroviral therapy: implications for long-term strategies.: Unique Identifier : AIDSLINE MED/20318456; Deeks SG; A variety of factors can contribute to the failure of combination antiretroviral therapy to durably suppress viral replication in patients infected with human immunodeficiency virus (HIV). Patients who have a low CD4(+) T cell count or high plasma viral load before therapy is initiated are at high risk for subsequent
Resistance against reverse transcriptase inhibitors.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S185-92. Unique Identifier : AIDSLINE MED/20318457; O'Brien WA; Departments of Medicine, Pathology, and Microbiology and; Immunology, University of Texas Medical Branch, Galveston, TX; 77555-0835, USA. wobrien@utmb.edu.; The response to antiretroviral therapy in human immunodeficiency virus (HIV)-infected patients is limited by the emergence of drug resistance. This resistance is a consequence of the high rate of HIV mutation, the high rate of viral replication (especially when potent multidrug therapies are not used or taken reliably
Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7. Unique Identifier : AIDSLINE MED/20318458; Lori F; Lisziewicz J; Research Institute for Genetic and Human Therapy, Washington, DC; 20007, USA. RIGHT@gunet.georgetown.edu.; Hydroxyurea has been extensively used in medical practice, mainly for treating chronic myelogenous leukemia, sickle cell anemia, and other diseases. In light of its ability to inhibit DNA synthesis and to induce cell cycle arrest through inhibition of ribonucleotide reductase, the effects of hydroxyurea on replication
Critical issues surrounding treatment in the era of active antiretroviral therapeutics. Proceedings of a conference.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S95-197. Unique Identifier : AIDSLINE MED/20430968
Management of the adverse effects of antiretroviral therapy and medication adherence.: Clin Infect Dis. 2000 Jun;30 Suppl 2:S96-116. Unique Identifier : AIDSLINE MED/20318447; Max B; Sherer R; CORE Center for Prevention, Care, and Research of Infectious; Disease, Division of Infectious Disease, Chicago, IL 60612, USA.; bmax@corecenter.org; A commonly cited cause of poor adherence to highly active antiretroviral therapy (HAART) is adverse drug reactions. Short-term adverse effects are potential threats to successful introduction and maintenance of HAART. The long-term toxicities of HAART are still emerging and being defined, as evidenced by the recently
A large, simple trial of a tuberculosis vaccine.: Clin Infect Dis. 2000 Jun;30 Suppl 3:S213-6. Unique Identifier : AIDSLINE MED/20336483; Horsburgh CR Jr; Department of Epidemiology and Biostatistics, Boston University; School of Public Health, Boston, MA 02118, USA. rhorsbu@bu.edu.; Although there are no new tuberculosis vaccines currently available, it is possible to estimate the infrastructure needed for efficacy trials of such a vaccine. A randomized, placebo-controlled vaccine strategy for community-wide vaccination of adults is proposed: a large, simple trial with recipients stratified at en
Applying experiences from trials of bacille Calmette-Guerin vaccine.: Clin Infect Dis. 2000 Jun;30 Suppl 3:S262-5. Unique Identifier : AIDSLINE MED/20336493; Wilson ME; Harvard Medical School and the Harvard School of Public Health,; Boston, and Division of Infectious Diseases, Mount Auburn; Hospital, Cambridge, MA 02238, USA. mary_wilson@harvard.edu; Bacille Calmette-Guerin (BCG) vaccine, a live vaccine developed to prevent tuberculosis (TB), has been given to billions of persons over more than 7 decades. Studies of the efficacy of BCG vaccine have had widely divergent results, underscoring the complexity of the biology and immunology of TB. The long duration of T
Improving vaccine performance with adjuvants.: Clin Infect Dis. 2000 Jun;30 Suppl 3:S266-70. Unique Identifier : AIDSLINE MED/20336494; Vogel FR; Vaccine and Prevention Research Program, Division of AIDS,; National Institute of Allergy and Infectious Diseases, Bethesda,; MD, USA. fred.vogel@aventis.com.; New vaccines are presently under development and in testing for the control of infectious diseases, including human immunodeficiency virus (HIV) and tuberculosis. Several of these vaccines are composed of synthetic, recombinant, or highly purified subunit antigens. Subunit vaccines are designed to include only the ant
Safety and immunogenicity of a five-dose series of inactivated Mycobacterium vaccae vaccination for the prevention of HIV-associated tuberculosis.: Clin Infect Dis. 2000 Jun;30 Suppl 3:S309-15. Unique Identifier : AIDSLINE MED/20336503; Waddell RD; Chintu C; Lein AD; Zumla A; Karagas MR; Baboo KS; Habbema JD; Tosteson AN; Morin P; Tvaroha S; Arbeit RD; Mwinga A; von Reyn CF; Infectious Disease Section, Department of Medicine,; Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.; Five doses of inactivated Mycobacterium vaccae vaccine were administered intradermally to 22 human immunodeficiency virus (HIV)-infected patients (11 bacille Calmette-Guerin [BCG]-positive and 11 BCG-negative) in Zambia whose CD4 lymphocyte counts were >/=200 cells/mm(3). HIV viral
Recombinant protein production driven by the tryptophan promoter is tightly controlled in ICONE 200, a new genetically engineered E. coli mutant.: Biotechnol Bioeng. 2000 Aug 20;69(4):351-8. Unique Identifier : AIDSLINE MED/20320602; Chevalet L; Robert A; Gueneau F; Bonnefoy JY; Nguyen T; Centre d'Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74164; Saint-Julien en Genevois, France.; laurent.chevalet@pierre-fabre.com; Batch processes for recombinant gene expression in prokaryotic systems should optimally comprise a growth phase with minimal promoter activity followed by a short phase favoring expression. The strong promoter of the tryptophan operon (Ptrp) gives high-level expression of recombinant proteins in E. coli. The inefficie
Molecular fingerprinting of Mycobacterium tuberculosis strains isolated in Vietnam using IS6110 as probe.: Tuber Lung Dis. 2000;80(2):75-83. Unique Identifier : AIDSLINE MED/20369983; Le TK; Bach KH; Ho ML; Le NV; Nguyen TN; Chevrier D; Guesdon JL; National Institute of Hygiene and Epidemiology, Hanoi.; SETTING: Northern and Southern areas of Vietnam . OBJECTIVE: To study the correlation between DNA fingerprinting of 168 Mycobacterium tuberculosis strains isolated from patients with a particular historical past (political separation of Vietnam for 20 years) and data about geograph
Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein.: Blood. 2000 Aug 15;96(4):1206-14. Unique Identifier : AIDSLINE MED/20399974; Kelly PF; Vandergriff J; Nathwani A; Nienhuis AW; Vanin EF; Division of Experimental Hematology, Department of Hematology/; Oncology, St Jude Children's Research Hospital, Memphis, TN; 38105, USA.; Limited expression of the amphotropic envelope receptor is a recognized barrier to efficient oncoretroviral vector-mediated gene transfer. Human hematopoietic cell lines and cord blood-derived CD34(+) and CD34(+), CD38(-) cell populations and the progenitors contained therein were transduced far more efficiently with
Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins.: Blood. 2000 Aug 15;96(4):1309-16. Unique Identifier : AIDSLINE MED/20399987; Chinnasamy D; Chinnasamy N; Enriquez MJ; Otsu M; Morgan RA; Candotti F; Clinical Gene Therapy Branch, National Human Genome Research; Institute, National Institutes of Health, Bethesda, MD; 20892-1851, USA.; Resting lymphocytes are refractory to gene transfer using Moloney murine leukemia virus (MMLV)-based retroviral vectors because of their quiescent status. Recently, it has been shown that lentiviral vectors are capable of transferring genes into nondividing and terminally differentiated cells. We used human immunodefi
Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage- colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses.: Blood. 2000 Aug 15;96(4):1317-26. Unique Identifier : AIDSLINE MED/20399988; Stripecke R; Cardoso AA; Pepper KA; Skelton DC; Yu XJ; Mascarenhas L; Weinberg KI; Nadler LM; Kohn DB; Institute for Genetic Medicine, University of Southern California; Keck School of Medicine, USA.; Cell vaccines engineered to express immunomodulators have shown feasibility in eliminating leukemia in murine models. Vectors for efficient gene delivery to primary human leukemia cells are required to translate this approach to clinical trials. In this study, second-generation lentiviral vectors derived from human im
Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro.: Unique Identifier : AIDSLINE MED/20399989; Gruber A; Kan-Mitchell J; Kuhen KL; Mukai T; Wong-Staal F; Dendritic cells (DCs) genetically modified to continually express
HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.: Blood. 2000 Aug 15;96(4):1438-42. Unique Identifier : AIDSLINE MED/20400004; Ullrich CK; Groopman JE; Ganju RK; Divisions of Experimental Medicine and Hematology/Oncology, Beth; Israel Deaconess Medical Center, Harvard Medical School, Boston,; MA 02115, USA. rganju@caregroup.harvard.edu; The immune dysfunction and cell destruction that occur in the human immunodeficiency virus (HIV)-infected host appear to result from the direct cytopathic effects of viral infection and the effects of viral proteins on uninfected bystander cells. Recently, the alpha-chemokine receptor CXCR4 has been reported to mediat
Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys.: Blood. 2000 Aug 15;96(4):1474-9. Unique Identifier : AIDSLINE MED/20400009; Kuroda MJ; Schmitz JE; Seth A; Veazey RS; Nickerson CE; Lifton MA; Dailey PJ; Forman MA; Racz P; Tenner-Racz K; Letvin NL; Division of Viral Pathogenesis, Department of Medicine, Beth; Israel Deaconess Medical Center, Harvard Medical School, Boston,; MA 02215, USA. mkuroda@caregroup.harvard.edu; Major histocompatibility class I-peptide tetramer technology and simian immunodeficiency virus of macaques (SIVmac)-infected rhesus monkeys were used to clarify the distribution of acquired immunodeficiency syndrome virus-specific cytotoxic T lymphocytes (CTL) in secondary lymphoid organs and to assess the relationshi
Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions.: Blood. 2000 Aug 15;96(4):1599-601. Unique Identifier : AIDSLINE MED/20400030; Aoki Y; Yarchoan R; Braun J; Iwamoto A; Tosato G; Medicine Branch and HIV and AIDS Malignancy Branch, National; Cancer Institute, National Institutes of Health, Bethesda, MD; 20892, USA. aokiy@mail.nih.gov; Kaposi sarcoma-associated herpesvirus encodes viral IL-6 (vIL-6). To investigate the potential role of vIL-6 in the pathogenesis of human immunodeficiency virus (HIV)- related primary effusion lymphomas (PEL), a sensitive enzyme-linked immunosorbent assay was developed for vIL-6 and applied to the study of PEL. Wherea
Ly-1b cells and Castleman disease [letter]: Blood. 2000 Aug 15;96(4):1614-6. Unique Identifier : AIDSLINE MED/20433037; Menke DM
Gag-derived proteins of HIV-1 isolates from Indian patients: cloning, expression, and purification of p24 of B- and C-subtypes.: Protein Expr Purif. 2000 Aug;19(3):321-8. Unique Identifier : AIDSLINE MED/20372567; Gupta S; Arora K; Gupta A; Chaudhary VK; Department of Biochemistry, University of Delhi South Campus,; Benito Juarez Road, New Delhi, 110 021, India.; A simple and efficient method for hyperexpression in Escherichia coli and purification of capsid protein, p24, of human immunodeficiency virus type 1 (HIV-1) of both B- and C-subtypes is described. DNA-encoding p24 of C-subtype was cloned from C-subtype gag sequence which was obtained by PCR amplification using DNA ex
The adjuvant effect of particles-importance of genetic background and pre-sensitisation.: Int Arch Allergy Immunol. 2000 Jul;122(3):167-73. Unique Identifier : AIDSLINE MED/20359155; Granum B; Gaarder PI; Eikeset A; Stensby BA; Lovik M; Department of Environmental Medicine, National Institute of; Public Health, Ulleval University Hospital, Oslo, Norway.; berit.granum@folkehelsa.no; BACKGROUND: We have previously reported that simple and well-characterised particles, such as polystyrene particles (PSP), have an IgE adjuvant effect in mice. The purpose of this study was to explore the importance of genetic background concerning the adjuvant effect of PSP in different strains of mice. METHODS: Inbr
Resting B cells are not antigen-presenting cells in the induction of oral tolerance of specific Th2 immune responses in mice.: Int Arch Allergy Immunol. 2000 Jul;122(3):174-81. Unique Identifier : AIDSLINE MED/20359156; Peng HJ; Chang ZN; Kuo SW; Lee CC; Tzau YY; Department of Medical Research, Veterans General Hospital -; Taipei, Taiwan. hjpeng@vghtpe.gov.tw; BACKGROUND: It has been shown that antigen presentation by resting B cells can induce tolerance to intravenously administered protein antigens, but the role of resting B cells in the induction of oral tolerance is unclear. METHODS: Mice continuously treated since birth with rabbit anti-mouse IgM serum for 5 weeks were
Mandela restores morale of AIDS conference [news]: BMJ. 2000 Jul 22;321(7255):193. Unique Identifier : AIDSLINE MED/20363596; Sidley P
Infant feeding and HIV study does not support Minerva's view [letter]: BMJ. 2000 Jul 29;321(7256):303. Unique Identifier : AIDSLINE MED/20426861; Sachs M; Buchanan P; Broadfoot M; Greiner T
The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.: Hum Mol Genet. 2000 Jun 12;9(10):1487-93. Unique Identifier : AIDSLINE MED/20347688; Tamanini F; Kirkpatrick LL; Schonkeren J; van Unen L; Bontekoe C; Bakker C; Nelson DL; Galjaard H; Oostra BA; Hoogeveen AT; Department of Clinical Genetics and Centre for Biomedical; Genetics, Erasmus University, Rotterdam, The Netherlands.; Fragile X syndrome is caused by the absence of the fragile X mental-retardation protein (FMRP). FMRP and the fragile X-related proteins 1 and 2 (FXR1P and FXR2P) form a gene family with functional similarities, such as RNA binding, polyribosomal association and nucleocytoplasmic shuttling. In a previous study, we foun
Effect of melatonin treatment on 24-h variations in responses to mitogens and lymphocyte subset populations in rat submaxillary lymph nodes.: J Neuroendocrinol. 2000 Aug;12(8):758-65. Unique Identifier : AIDSLINE MED/20387617; Castrillon PO; Esquifino AI; Varas A; Zapata A; Cutrera RA; Cardinali DP; Departamento de Bioquimica y Biologia Molecular III, Facultad; de Medicina, Universidad Complutense, Madrid, Spain.; Wistar male rats were injected s.c. with melatonin (30 microg) or vehicle, 1 h before lights off, for 11 days. Ten days after beginning melatonin treatment, rats received Freund s complete adjuvant or its vehicle s.c., and after 2 days, they were sacrificed at six different time intervals throughout a 24-h cycle. The
Global HIV epidemic continues to grow.: Commun Dis Rep CDR Wkly. 2000 Jul 7;10(27):241, 244. Unique Identifier : AIDSLINE MED/20364747
Further increase in prevalent diagnosed HIV infections in the United Kingdom 1999.: Commun Dis Rep CDR Wkly. 2000 Jul 28;10(30):265, 268. Unique Identifier : AIDSLINE MED/20395094
AIDS and HIV infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 2000 Jul 28;10(30):273-6. Unique Identifier : AIDSLINE MED/20395095
Assessing the relationship between child sexual abuse and marginal living conditions on HIV/AIDS-related risk behavior among women prisoners.: Child Abuse Negl. 2000 May;24(5):677-88. Unique Identifier : AIDSLINE MED/20277224; Mullings JL; Marquart JW; Brewer VE; Sam Houston State University, College of Criminal Justice,; Huntsville, TX 77341, USA.; OBJECTIVE: There were two aims in this research. First, to examine the relationships between childhood sexual abuse and HIV drug and sexual risk taking behaviors among female prisoners, and second, to examine the relationship between a marginal adult living context and HIV drug and sexual risk taking behavior among fe
Sensitivity, specificity, and positive predictive value of oral opportunistic infections in adults with HIV/AIDS as markers of immune suppression and viral burden.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Aug;90(2):182-8. Unique Identifier : AIDSLINE MED/20396651; Patton LL; Department of Dental Ecology, University of North Carolina at; Chapel Hill, Chapel Hill, NC 27599-7450, USA.; Lauren_Patton@Dentistry.UNC.EDU; OBJECTIVES: The purpose of this study was to assess the use of human immunodeficiency virus (HIV)-related oral opportunistic infections as markers of immune suppression and viral burden in adults with HIV/acquired immunodeficiency syndrome (AIDS). METHODS: The population consisted of a single institution observational
Tuberculous pericarditis and HIV infection [editorial; comment]: Heart. 2000 Aug;84(2):127-8. Unique Identifier : AIDSLINE MED/20368819; Wragg A; Strang JI
Double blind randomised placebo controlled trial of adjunctive prednisolone in the treatment of effusive tuberculous pericarditis in HIV seropositive patients.: Heart. 2000 Aug;84(2):183-8. Unique Identifier : AIDSLINE MED/20368834; Hakim JG; Ternouth I; Mushangi E; Siziya S; Robertson V; Malin A; Department of Medicine, University of Zimbabwe, Avondale, Harare.; jghakim@healthnet.zw; OBJECTIVE: To determine the effect of adjunctive prednisolone on morbidity, pericardial fluid resolution, and mortality in HIV seropositive patients with effusive tuberculous pericarditis. DESIGN: Double blind randomised placebo controlled trial. SETTING: Two medical school affiliated referral hospitals in Harare,
Frequent detection of HIV-1 RNA but low rates of HIV-1 isolation in cervicovaginal secretions from infected women.: New Microbiol. 2000 Jan;23(1):79-83. Unique Identifier : AIDSLINE MED/20402871; Saracino A; Di Stefano M; Fiore JR; Lepera A; Raimondi D; Angarano G; Pastore G; Clinic of Infectious Diseases, University of Bari, Italy.; Information regarding the presence of HIV-1 in the female genital tract is necessary to gain insight into the mechanism of HIV-1 heterosexual transmission. Herein, we present the results of a study on virus isolation and HIV-1 RNA detection from cervicovaginal lavage (CVL) samples from 25 HIV-1 seropositive women. Des
Limited secretory-IgA response in cervicovaginal secretions from HIV-1 infected, but not high risk seronegative women: lack of correlation to genital viral shedding.: New Microbiol. 2000 Jan;23(1):85-92. Unique Identifier : AIDSLINE MED/20402872; Fiore JR; Laddago V; Lepera A; La Grasta L; Di Stefano M; Saracino A; Lopalco P; Pastore G; Angarano G; Clinic of Infectious Diseases, University of Bari, Italy.; The presence and antigen specificity of IgG and secretory-IgA (s-IgA) to HIV-1 were evaluated in cervicovaginal lavages (CVL) from 26 infected and 10 high-risk seronegative women. All the seropositive women had detectable IgG recognizing several viral antigens, while a smaller percentage of women demonstrated s-IgA to
Occupational HIV exposure.: Med Health R I. 2000 Jul;83(7):207-10. Unique Identifier : AIDSLINE MED/20390479; Mileno MD; Brown University School of Medicine, USA. mmileno@lifespan.org
Non-occupational postexposure HIV prophylaxis: clinical issues and public health questions.: Med Health R I. 2000 Jul;83(7):210-3. Unique Identifier : AIDSLINE MED/20390480; Mayer KH; Kwong J; Singal R; Boswell S; Infectious Disease Division, Memorial Hopsital of RI, Pawtucket; 02960, USA. Kenneth_Mayer@brown.edu
Sample cases of exposure.: Med Health R I. 2000 Jul;83(7):215-6. Unique Identifier : AIDSLINE MED/20390482; Tauber MG; Canning BR; Hinckley, Allen & Snyder, LLP, Providence, RI 02903, USA.; mtauber@haslaw.com
Rhode Island's Syringe Exchange Program (ENCORE).: Med Health R I. 2000 Jul;83(7):216-8. Unique Identifier : AIDSLINE MED/20390483; Latta ET; Rhode Island Department of Health, Providence 02908, USA.; TimL@doh.state.ri.us
Effectiveness of imaging studies in acute appendicitis: a simplified decision model.: Eur J Emerg Med. 2000 Mar;7(1):25-30. Unique Identifier : AIDSLINE MED/20296185; Van Hoe L; Miserez M; Department of Radiology, University Hospitals Leuven, Belgium.; Computed tomography (CT) and ultrasonography (US) have been proposed as non-invasive diagnostic aids in patients with suspected acute appendicitis. Currently, clear guidelines about the indications to use these techniques are lacking. Using the concepts of decision analysis, a model was created to calculate the effect
Influence of interferon gamma on modulation of Fas expression by human colon carcinoma cells and their subsequent sensitivity to antigen-specific CD8+ cytotoxic T lymphocyte attack.: Cancer Immunol Immunother. 2000 Jul;49(4-5):193-207. Unique Identifier : AIDSLINE MED/20395350; Bergmann-Leitner ES; Abrams SI; Laboratory of Tumor Immunology and Biology, National Cancer; Institute, National Institutes of Health, Bethesda, MD; 20892-1402, USA.; The inability of certain neoplastic populations to undergo Fas-mediated death by immune effector mechanisms may confer a selective survival advantage, which may contribute to tumor escape. In this study, we examined the role of Fas-mediated lysis in a human-antigen (Ag)-specific cytotoxic T lymphocyte (CTL)/colon carc
LFA-3 plasmid DNA enhances Ag-specific humoral- and cellular-mediated protective immunity against herpes simplex virus-2 in vivo: involvement of CD4+ T cells in protection.: Cell Immunol. 2000 Jul 10;203(1):19-28. Unique Identifier : AIDSLINE MED/20377504; Sin JI; Kim J; Dang K; Lee D; Patchuk C; Satishchandran C; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, 505 Stellar-Chance Lab, 422 Curie Drive,; Philadelphia, Pennsylvania 19104, USA.; Adhesion molecules are important for cell trafficking and delivery of secondary signals for stimulation of T cells and antigen-presenting cells (APCs) in a variety of immune and inflammatory responses. Adhesion molecules lymphocyte function-associated antigen (LFA)-1 and CD2 on T cells recognize intercellular adhesion
The role of DNA amplification technology in the diagnosis of infectious diseases.: CMAJ. 2000 Aug 8;163(3):301-9. Unique Identifier : AIDSLINE MED/20407700; Louie M; Louie L; Simor AE; Department of Microbiology, Sunnybrook & Women's College Health; Sciences Centre, Toronto, Ont.; Nucleic acid amplification and detection methods developed in the past decade are useful for the diagnosis and management of a variety of infectious diseases. The most widely used of these methods is the polymerase chain reaction (PCR). PCR assays can detect rapidly and accurately the presence of fastidious and slow-g
Rate of HIV infection on rise among Ontario's gay men [news]: CMAJ. 2000 Aug 8;163(3):321. Unique Identifier : AIDSLINE MED/20407701
Letter from Durban [news]: CMAJ. 2000 Aug 8;163(3):322-3. Unique Identifier : AIDSLINE MED/20407703; Jeffery A
AIDS and globalisation [editorial]: Sex Transm Infect. 2000 Jun;76(3):154-5. Unique Identifier : AIDSLINE MED/20416872; Shahmanesh M; Shahmanesh M; Miller R
Report of sexually transmitted diseases by HIV infected men during follow up: time to target the HIV infected?: Sex Transm Infect. 2000 Jun;76(3):188-92. Unique Identifier : AIDSLINE MED/20416880; Machekano RN; Bassett MT; Zhou PS; Mbizvo MT; Latif AS; Katzenstein DA; Zimbabwe AIDS Prevention Project, University of Zimbabwe Medical; School.; OBJECTIVES: To compare the rate of self reported sexually transmitted diseases (STDs) among HIV infected men with men who remained HIV negative during follow up of a Harare male factory cohort. METHODS: Male factory workers were offered enrolment and behavioural data were collected at entry then every 6 months, along
Survival by AIDS defining condition in rural Uganda.: Sex Transm Infect. 2000 Jun;76(3):193-7. Unique Identifier : AIDSLINE MED/20416881; Morgan D; Malamba SS; Orem J; Mayanja B; Okongo M; Whitworth JA; Medical Research Council Programme on AIDS/Uganda Virus Research; Institute, Entebbe, Uganda. mrc@starcom.co.ug; OBJECTIVES: To report the initial AIDS defining conditions, CD4 lymphocyte counts around the time of AIDS diagnosis, and survival by AIDS defining condition in a population based cohort in rural Uganda . METHODS: Participants in an HIV natural history cohort in rural Uganda were rev
Ethnic and demographic variations in HIV/AIDS presentation at two London referral centres 1995-9.: Sex Transm Infect. 2000 Jun;76(3):215. Unique Identifier : AIDSLINE MED/20416888; Saul J; Erwin J; Bruce JC; Peters B; Academic Department of Genitourinary Medicine, Guy's, King's and; St Thomas's Medical School, St Thomas's Hospital, London.
Carbamazepine in Reiter's syndrome [letter]: Sex Transm Infect. 2000 Jun;76(3):220. Unique Identifier : AIDSLINE MED/20416891; Goyal NN; Dhurat RS; Jerajani HR
HIV associated cytomegalovirus retinitis in Melbourne, Australia [letter]: Sex Transm Infect. 2000 Jun;76(3):221. Unique Identifier : AIDSLINE MED/20416894; Cherry CL; Mijch AM; Hoy JF; Hall AJ; Hellard ME; Bryant M; DeGraaff B; Fairley CK
Photosensitivity reaction of efavirenz [letter]: Sex Transm Infect. 2000 Jun;76(3):221. Unique Identifier : AIDSLINE MED/20416893; Newell A; Avila C; Rodgers ME
Simultaneous determination of zidovudine and its monophosphate in mouse plasma and peripheral red blood cells by high-performance liquid chromatography.: J Chromatogr B Biomed Sci Appl. 2000 Apr 14;740(2):281-7. Unique Identifier : AIDSLINE MED/20279435; Tan X; Boudinot FD; Department of Pharmaceutical and Biomedical Sciences, College of; Pharmacy, University of Georgia, Athens 30602-2353, USA.; Novel prodrugs for the intracellular delivery of zidovudine monophosphate (AZTMP) have recently been designed. To investigate the bioconversion and pharmacokinetic profiles of these compounds, an analytical method for the simultaneous determination of zidovudine (AZT) and AZTMP in mouse plasma and peripheral red blood
pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery.: Unique Identifier : AIDSLINE MED/20345330; Risbud MV; Hardikar AA; Bhat SV; Bhonde RR; The aim of this study was to develop a pH-sensitive chitosan/polyvinyl pyrrolidone (PVP) based controlled drug release system for antibiotic delivery. The hydrogels were synthesised by crosslinking chitosan and PVP blend with glutaraldehyde to form a semi-interpenetrating polymer network (semi-IPN). The semi-IPN forma
Deaths: final data for 1998.: Natl Vital Stat Rep. 2000 Jul 24;48(11):1-105. Unique Identifier : AIDSLINE MED/20390516; Murphy SL; OBJECTIVES: This report presents final 1998 data on U.S. deaths and death rates according to demographic and medical characteristics such as age, sex, race, Hispanic origin, marital status, educational attainment, injury at work, State of residence, and cause of death. Trends and patterns in general mortality, life ex
The critical role of Th1-dominant immunity in tumor immunology.: Cancer Chemother Pharmacol. 2000;46 Suppl:S52-61. Unique Identifier : AIDSLINE MED/20405082; Nishimura T; Nakui M; Sato M; Iwakabe K; Kitamura H; Sekimoto M; Ohta A; Koda T; Nishimura S; Division of Immunoregulation, Institute for Genetic Medicine,; Hokkaido University, Sapporo, Japan. tak24@imm.hokudai.ac.jp; To investigate the precise role of antigen-specific Th1 and Th2 cells in tumor immunity, we developed a novel adoptive tumor-immunotherapy model using OVA-specific Th1 and Th2 cells and an OVA gene-transfected tumor. This therapeutic model demonstrated that both antigen-specific Th1 and Th2 cells had strong antitumor
Human CD8 and CD4 T cell epitopes of epithelial cancer antigens.: Cancer Chemother Pharmacol. 2000;46 Suppl:S86-90. Unique Identifier : AIDSLINE MED/20405088; Sato N; Nabeta Y; Kondo H; Sahara H; Hirohashi Y; Kashiwagi K; Kanaseki T; Sato Y; Rong S; Hirai I; Kamiguchi K; Tamura Y; Matsuura A; Takahashi S; Torigoe T; Ikeda H; Department of Pathology, Sapporo Medical University School of; Medicine, Japan. nsatou@sapmed.ac.jp; Recent human tumor immunology research has identified several genes coding immunogenic peptides recognized by CD8 cytotoxic T lymphocytes (CTLs) in melanoma tumors. Very recently, CD4 T cell antigenic epitopes were also determined in certain melanoma tumors. The use of these peptides in conjunction with human immunoth
Cells of the monocyte-macrophage lineage and pathogenesis of HIV-1 infection.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):413-29. Unique Identifier : AIDSLINE MED/20415775; Martin JC; Bandres JC; New York Harbor VA Medical Center, New York, USA.; It is thought that monocyte-macrophages and probably dendritic cells play a central role in HIV-1 primary infection, as well as in its evolution, given that they are among the first cells infected and later function as important reservoirs for the virus. These cells may participate in the selection of certain viral st
Interactions among combinations of two and three protease inhibitors against drug-susceptible and drug-resistant HIV-1 isolates.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):430-6. Unique Identifier : AIDSLINE MED/20415776; Tremblay C; Merrill DP; Chou TC; Hirsch MS; Infectious Diseases Unit, Massachusetts General Hospital and; Harvard Medical School, Boston 02114, USA.; Protease inhibitors used in combination with reverse transcriptase inhibitors have demonstrated potent anti-HIV-1 activity in vitro as well as in vivo. We evaluated interactions among five protease inhibitors :
Impact of early HIV-1 RNA and T-lymphocyte dynamics during primary HIV-1 infection on the subsequent course of HIV-1 RNA levels and CD4+ T-lymphocyte counts in the first year of HIV-1 infection. Sydney Primary HIV Infection Study Group.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):437-44. Unique Identifier : AIDSLINE MED/20415777; Kaufmann GR; Cunningham P; Zaunders J; Law M; Vizzard J; Carr A; Cooper DA; Centre for Immunology, St. Vincent's Hospital, Sydney, New South; Wales, Australia. gkaufmann@nchecr.unsw.edu.au; Plasma HIV-1 RNA and CD4+ T-cell counts after HIV-1 seroconversion are important independent markers that predict the clinical course of HIV-1 infection. The prognostic significance of these parameters during primary HIV-1 infection, however, remains largely unknown. In a cohort of 53 male study subjects (age, 33 +/-
Telomere loss in peripheral blood mononuclear cells may be moderately accelerated during highly active antiretroviral therapy (HAART).: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):445-52. Unique Identifier : AIDSLINE MED/20415778; Hotchkiss G; Pehrson PO; Larsson S; Ahrlund-Richter L; Britton S; Department of Medical Nutrition, Karolinska Institute, Huddinge; University Hospital, Sweden. graham.hotchkiss@mednut.ki.se; It has been speculated that infection with HIV-1 may lead to a significant increase in turnover, and subsequent exhaustion, of immune repopulation. Given that telomeric DNA is lost on mitotic replication, telomere lengths can be used as an indirect gauge of this rate. We have analyzed the mean telomere restriction fra
Efavirenz, nelfinavir, and stavudine rescue combination therapy in HIV-1-positive patients heavily pretreated with nucleoside analogues and protease inhibitors.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):453-60. Unique Identifier : AIDSLINE MED/20415779; Seminari E; Maggiolo F; Villani P; Suter F; Pan A; Regazzi MB; Tinelli C; Maserati R; Istituto di Malattie Infettive, Universita di Pavia, Italy.; Tolerability, activity, and pharmacokinetic parameters of a combination therapy with efavirenz (EFV), nelfinavir (NFV), and stavudine
Intravenous drug use, relationship with providers, and stage of HIV disease influence the prescription rates of protease inhibitors.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):461-6. Unique Identifier : AIDSLINE MED/20415780; Murri R; Fantoni M; Del Borgo C; Izzi I; Visona R; Suter F; Banfi MC; Barchi E; Orchi N; Bosco O; Wu AW; Department of Infectious Diseases, Catholic University, Rome,; Italy. ritanto@iol.it; OBJECTIVE: To assess rates of prescriptions of protease inhibitors (PI) and determinants of not being prescribed PIs in a cohort of HIV-infected people eligible (according to published guidelines) for highly active antiretroviral therapy (HAART). DESIGN: Cross-secti
Immunologic responses of HIV-1-infected study subjects to immunization with a mixture of peptide protein derivative-V3 loop peptide conjugates.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):467-76. Unique Identifier : AIDSLINE MED/20415781; Rubinstein A; Mizrachi Y; Pettoello-Mantovani M; Lenz J; Liu GQ; Rubinstein Y; Goldstein H; Yust I; Burke M; Vardinon N; Spirer Z; Cryz SJ Jr; Department of Pediatrics, Center for AIDS Research, Albert; Einstein College of Medicine of Yeshiva University, Bronx, New; York 10461, USA. rubinste@aecom.yu.edu; V3 loop peptide sequences from several HIV-1 strains were covalently linked to purified protein derivative (PPD) of Mycobacterium tuberculosis. A mixture of PPD conjugates of V3 loop peptides from six different strains of HIV-1 induced a stronger antibody response than a single V3 peptide-conjugate administered to gui
Incorporation of 3'-azido-3'-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT dose.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):477-83. Unique Identifier : AIDSLINE MED/20415782; Poirier MC; Patterson TA; Slikker W Jr; Olivero OA; Division of Basic Sciences, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.; poirierm@exchange.nih.gov; In the United States , the nucleoside analogue drug 3 -azido-3 deoxythymidine ( AZT ; also called zidovudine or ZDV) is given to most pregnant women who produce a positive test result for HIV-1. To investigate transplacen
Detection of early HIV infection and estimation of incidence using a sensitive/less-sensitive enzyme immunoassay testing strategy at anonymous counseling and testing sites in San Francisco.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):484-9. Unique Identifier : AIDSLINE MED/20415783; McFarland W; Busch MP; Kellogg TA; Rawal BD; Satten GA; Katz MH; Dilley J; Janssen RS; Department of Public Health, San Francisco, California; 94102-6033, USA. Willi_McFarland@dph.sf.ca.us; Timely estimates of HIV incidence are needed to monitor the epidemic and target primary prevention but have been difficult to obtain. We applied a sensitive/ less-sensitive (S/LS) enzyme immunoassay (EIA) testing strategy to stored HIV-positive sera (N = 452) to identify early infections, estimate incidence, and chara
High-risk sexual behavior in Los Angeles: who receives testing for HIV?: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):490-7. Unique Identifier : AIDSLINE MED/20415784; Miller LG; Simon PA; Miller ME; Long A; Yu EI; Asch SM; Division of Infectious Diseases, VA Greater Los Angeles; Healthcare System, UCLA Medical Center, and UCLA AIDS Institute,; Los Angeles, California 90509, USA. lgmiller@ucla.edu; No recent population-based data on HIV testing in people with high-risk sexual behavior are available. We sought predictors of testing using data from the 1997 Los Angeles County Health Survey, a random-digit telephone survey of 8004 county households. An estimated 2.3 million (35.5%) adults were tested for HIV in the
Adherence to antiretroviral medications in an inner-city population.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):498-502. Unique Identifier : AIDSLINE MED/20415785; Weidle PJ; Ganera CE; Irwin KL; McGowan JP; Ernst JA; Olivo N; Holmberg SD; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA. pew6@cdc.gov; Adherence to antiretroviral medications is essential for optimal treatment of HIV infection. We investigated nonadherence to antiretroviral medications in an inner-city population by using a confidential interview and a self-administered anonymous questionnaire. We estimated adherence on the day before and the month b
Characteristics of hospitalizations of HIV-infected patients: an analysis of data from the 1994 healthcare cost and utilization project.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):503-8. Unique Identifier : AIDSLINE MED/20415786; Bentham WD; Cai L; Schulman KA; Department of Medicine, Georgetown University Medical Center,; Washington, DC, USA.; Hospitals are significant resources for care of HIV/AIDS patients. Previous studies that have attempted to identify and track the characteristics of these patients and their hospitalizations have been limited in their ability to produce national estimates of patient use of such resources. This study, using data from t
Immunologic and clinical stages in HIV-1-infected Ugandan adults are comparable and provide no evidence of rapid progression but poor survival with advanced disease.: J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):509-16. Unique Identifier : AIDSLINE MED/20415787; French N; Mujugira A; Nakiyingi J; Mulder D; Janoff EN; Gilks CF; Medical Research Council/Department for International; Development/Uganda Virus Research Institute Programme on AIDS in; Uganda, Entebbe.; Clear understanding of the natural history of HIV-1 disease is critical for planning and developing appropriate therapeutic strategies for HIV-1-infected populations in the developing world. Present knowledge about Africa is based on very limited data that largely use clinical staging as the prognostic marker; this ap
Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus.: Jpn J Infect Dis. 2000 Apr;53(2):67-9. Unique Identifier : AIDSLINE MED/20332382; Lusida MI; Soetjipto; Handajani R; Nidom CA; Soemarto; Darmadi S; Adi P; Fujii M; Fujita T; Ishido S; Hotta H; Tropical Disease Center, Airlangga University, Surabaya,; Indonesia.; The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV
4th International Workshop on HIV Drug Resistance and Treatment Strategies. Sitges, Spain, 12-16 June 2000. Abstracts.: Antivir Ther. 2000;5 Suppl 3:1-161. Unique Identifier : AIDSLINE MED/20418883
The role of cost-effectiveness analysis in assessing HIV-prevention interventions.: AIDS Public Policy J. 1997 Spring;12(1):21-30. Unique Identifier : AIDSLINE MED/20369687; Kahn JG; Sanstad KC; Department of Epidemiology and Biostatistics, University of; California, San Francisco, USA.
Home and community-based care funded by Title II of the Ryan White CARE Act: a survey of the states.: AIDS Public Policy J. 1997 Spring;12(1):3-20. Unique Identifier : AIDSLINE MED/20369686; Buchanan RJ; Department of Health Administration and Policy, Medical; University of South Carolina, Charleston, USA.
HIV education and prevention in California: problems and progress. HIV Education and Prevention Evaluation Team.: AIDS Public Policy J. 1997 Spring;12(1):31-45. Unique Identifier : AIDSLINE MED/20369688; Marx R; Franks PE; Kahn JG; Sanstad KC; Werdegar D; San Francisco Department of Public Health, AIDS Office,; California, USA.
Report from the field: participation of HIV-positive women in clinical research.: AIDS Public Policy J. 1997 Spring;12(1):46-52. Unique Identifier : AIDSLINE MED/20369689; Williams AB; Singh MP; Dos Santos K; Winfrey J; Mezger J; Yale School of Nursing, in New Haven, Connecticut, USA.
Health insurance continuation programs funded by Title II of the Ryan White CARE Act: a survey of the states.: AIDS Public Policy J. 1997 Summer;12(2):57-65. Unique Identifier : AIDSLINE MED/20369690; Buchanan RJ; Department of Community Health Administration and Policy, Medical; University of South Carolina, Charleston, USA.
Driving the epidemic underground? A new look at law and the social risk of HIV testing.: AIDS Public Policy J. 1997 Summer;12(2):66-78. Unique Identifier : AIDSLINE MED/20369691; Burris S; School of Law, Temple University, Philadelphia, USA.
Tradition and experiment in New Zealand AIDS policy.: AIDS Public Policy J. 1997 Summer;12(2):79-88. Unique Identifier : AIDSLINE MED/20369692; Lichtenstein B; Department of Sociology, University of Alabama, Birmingham, USA.
Demand for and use of advocacy services for persons living with HIV/AIDS. Four Special Projects of National Significance HIV Advocacy Projects.: AIDS Public Policy J. 1997 Summer;12(2):89-101. Unique Identifier : AIDSLINE MED/20369693; Hines R; Decker CL; Witt WP; Marconi K; Singer B; Office of Science and Epidemiology, Department of Health and; Human Services, Rockville, Maryland, USA.
The Ryan White CARE Act: the allocation of Title II funding among programs by the states.: AIDS Public Policy J. 1997 Fall;12(3):105-11. Unique Identifier : AIDSLINE MED/20369694; Buchanan RJ; Department of Health Administration and Policy, Medical; University of South Carolina, Charleston, USA.
The adequacy of reimbursement for HIV under Section 1115 Medicaid waivers.: AIDS Public Policy J. 1997 Fall;12(3):112-27. Unique Identifier : AIDSLINE MED/20369695; Conviser R; Kerrigan D; Thompson S; Service Evaluation and Research Branch, U.S. Department of Health; and Human Services, Rockville, Maryland, USA.
Why the U.S. needs a national policy on condoms.: AIDS Public Policy J. 1997 Fall;12(3):128-35. Unique Identifier : AIDSLINE MED/20369696; Cohen DA; Farley TA; Bugg S; Department of Public Health and Preventive Medicine, Louisiana; State University Medical Center, New Orleans, USA.
Mchape: a wake-up call for AIDS control programs in Africa (a case history from Malawi).: AIDS Public Policy J. 1997 Fall;12(3):136-43. Unique Identifier : AIDSLINE MED/20369697; Waldorf S; Peace Corps, Malawi, Africa.
The AIDS Litigation Project: HIV/AIDS in the courts in the 1990s, Part 1.: AIDS Public Policy J. 1997 Winter;12(4):105-21. Unique Identifier : AIDSLINE MED/20369698; Gostin LO; Webber DW; Georgetown/Johns Hopkins Program on Law and Public Health,; Georgetown University Law Center, Washington, D.C., USA.
Tuberculosis and HIV infection: utilization of public programs to fund treatment.: AIDS Public Policy J. 1997 Winter;12(4):122-36. Unique Identifier : AIDSLINE MED/20369699; Buchanan RJ; Department of Health Administration and Policy, Medical; University of South Carolina, Charleston, USA.
Determining allocations for HIV-prevention interventions: assessing a change in federal funding policy.: AIDS Public Policy J. 1997 Winter;12(4):138-48. Unique Identifier : AIDSLINE MED/20369700; Valdiserri RO; Robinson C; Lin LS; West GR; Holtgrave DR; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia, USA.
The ethics of placebo-controlled trials for perinatal transmission of HIV in developing countries.: AIDS Public Policy J. 1998 Spring;13(1):20-9. Unique Identifier : AIDSLINE MED/20369702; Clark PA; Department of Theology, St. Joseph's University, Philadelphia,; Pennsylvania, USA.
The AIDS Litigation Project: HIV/AIDS in the courts in the 1990s, Part 2.: AIDS Public Policy J. 1998 Spring;13(1):3-19. Unique Identifier : AIDSLINE MED/20369701; Gostin LO; Webber DW; Georgetown/Johns Hopkins Program on Law and Public Health,; Georgetown University Law Center, Washington, D.C., USA.
The "best proven therapeutic method" standard in clinical trials in technologically developing countries.: AIDS Public Policy J. 1998 Spring;13(1):30-5. Unique Identifier : AIDSLINE MED/20369703; Levine RJ; Yale University School of Medicine, New Haven, Connecticut, USA.
Workshop report: AIDS and stigma: a conceptual framework and research agenda.: AIDS Public Policy J. 1998 Spring;13(1):36-47. Unique Identifier : AIDSLINE MED/20369704; Herek GM; Mitnick L; Burris S; Chesney M; Devine P; Fullilove MT; Fullilove R; Gunther HC; Levi J; Michaels S; Novick A; Pryor J; Snyder M; Sweeney T; Department of Psychology, University of California, Davis, USA.
HIV surveillance: what's hot, what's not [editorial].: AIDS Public Policy J. 1998 Summer;13(2):51-5. Unique Identifier : AIDSLINE MED/20369705; Novick A
Can access to care for people living with HIV be expanded?: AIDS Public Policy J. 1998 Summer;13(2):56-74. Unique Identifier : AIDSLINE MED/20369706; Levi J; Center for Health Policy Research, George Washington University; Medical Center, USA.
The perceptions and experiences of managed care by HIV-positive individuals in New York City.: AIDS Public Policy J. 1998 Summer;13(2):75-84. Unique Identifier : AIDSLINE MED/20369707; Halkitis PN; Dooha SM; Department of Applied Psychology, New York University, USA.
Testing the force: HIV and discrimination in the Australian military.: AIDS Public Policy J. 1998 Summer;13(2):85-90. Unique Identifier : AIDSLINE MED/20369708; Feldman EA; Institute for Law and Society, New York University, USA.
Economic and geographic diversity in AIDS incidence among HIV exposure groups in New York City: 1983 to 1995.: AIDS Public Policy J. 1998 Fall;13(3):103-14. Unique Identifier : AIDSLINE MED/20369711; Fordyce EJ; Shum R; Singh TP; Forlenza S; New York City Department of Health, Office of HIV/AIDS; Surveillance, USA.
Cost-effectiveness analysis and HIV prevention community planning.: AIDS Public Policy J. 1998 Fall;13(3):115-27. Unique Identifier : AIDSLINE MED/20369712; Pinkerton SD; Holtgrave DR; Willingham M; Goldstein E; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee, USA.
Bragdon v. Abbott: who's in? Who's out?: AIDS Public Policy J. 1998 Fall;13(3):99-102. Unique Identifier : AIDSLINE MED/20369710; Davis DS; Cleveland-Marshall College of Law, Cleveland State University,; Ohio, USA.
The ethics of needle-exchange programs.: AIDS Public Policy J. 1998 Winter;13(4):131-9. Unique Identifier : AIDSLINE MED/20369713; Clark PA; Department of Theology, St. Joseph's University, Philadelphia,; Pennsylvania, USA.
Expanding access to PEP: ethical and legal issues.: AIDS Public Policy J. 1998 Winter;13(4):140-67. Unique Identifier : AIDSLINE MED/20369714; Baylis F; Ginn D; Office of Bioethics Education and Research Faculty of Medicine,; Dalhousie University, Halifax, Nova Scotia, Canada.
Intrakines--evidence for a trans-cellular mechanism of action.: Mol Ther. 2000 Feb;1(2):165-70. Unique Identifier : AIDSLINE MED/20397453; Engel BC; Bauer G; Pepper KA; Bockstoce DC; Yu XJ; Chen SY; Kohn DB; Division of Research Immunology/Bone Marrow Transplantation,; Childrens Hospital Los Angeles, California 90027, USA.; Human CXCR4 is the receptor for the CXC chemokine SDF-1alpha and also acts as a coreceptor for T lymphotropic HIV-1 strains. Blocking the surface expression of this receptor via an intrakine approach has recently been shown to efficiently prevent HIV-1 infection of T cells. The CXC-chemokine gene is fused to an endopl
Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system.: Mol Ther. 2000 Feb;1(2):171-9. Unique Identifier : AIDSLINE MED/20397454; Schroers R; Sinha I; Segall H; Schmidt-Wolf IG; Rooney CM; Brenner MK; Sutton RE; Chen SY; Center for Cell and Gene Therapy, Baylor College of Medicine,; Houston, Texas 77030, USA.; Professional antigen-presenting cells, such as dendritic cells (DCs) and macrophages, are target cells for gene therapy of infectious disease and cancer. However, transduction of DCs and macrophages has proved difficult by most currently available gene transfer methods. Several recent studies have shown that lentivira
Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX.: Mol Ther. 2000 Mar;1(3):225-35. Unique Identifier : AIDSLINE MED/20391204; Fields PA; Kowalczyk DW; Arruda VR; Armstrong E; McCleland ML; Hagstrom JN; Pasi KJ; Ertl HC; Herzog RW; High KA; Department of Pediatrics, University of Pennsylvania Medical; Center and The Children's Hospital of Philadelphia, 19104, USA.; Defining immune responses against the secreted transgene product in a gene therapy setting is critical for treatment of genetic diseases such as hemophilia B (coagulation factor IX deficiency). We have previously shown that intramuscular administration of an adeno-associated viral (AAV) vector results in stable expres
Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo.: Mol Ther. 2000 Mar;1(3):244-54. Unique Identifier : AIDSLINE MED/20391206; Bai J; Gorantla S; Banda N; Cagnon L; Rossi J; Akkina R; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.; The cellular entry of HIV is mediated by the specific interaction of viral envelope glycoproteins with the cell-surface marker CD4 and a chemokine receptor (CCR5 or CXCR4). Individuals with a 32-base-pair (bp) deletion in the CCR5 coding region, which results in a truncated peptide, show resistance to HIV-1 infection.
Protection against retroviruses are owing to a different form of immunity. An RNA-based molecular immunity hypothesis.: Appl Immunohistochem Molecul Morphol. 2000 Jun;8(2):133-46. Unique Identifier : AIDSLINE MED/20392742; Bagasra O; Amjad M; Lincoln University, Department of Biology, PA 19352, USA.; bagasra@lu.lincoln.edu
Iodine absorption after intraoperative bowel irrigation with povidone-iodine.: Dis Colon Rectum. 2000 Aug;43(8):1127-32. Unique Identifier : AIDSLINE MED/20404945; Tsunoda A; Shibusawa M; Kamiyama G; Takata M; Choh H; Kusano M; Second Department of Surgery, School of Medicine, Showa; University, Tokyo, Japan.; PURPOSE: Povidone-iodine is a commonly used intrarectal tumoricidal agent in patients undergoing colorectal surgery. The aim of this study was to assess systemic absorption of total iodine and its effect on thyroid function after intrarectal application. METHODS: Twenty patients with carcinoma of the rectum received i
[Immunodeficiency and HIV virus infections today]: Duodecim. 1996;112(2):120-2. Unique Identifier : AIDSLINE MED/20058122; Leinikki P; Kansanterveyslaitos, HIV-laboratorio, Helsinki.
[Pathogenesis of HIV infections]: Duodecim. 1996;112(2):123-9. Unique Identifier : AIDSLINE MED/20058123; Saksela K; Rockefeller University, New York, NY 10021, USA.
[Evolution of HIV virus]: Duodecim. 1996;112(2):130-4. Unique Identifier : AIDSLINE MED/20058124; Salminen M; Leinikki P; Kansanterveyslaitos, Helsinki.
[Treatment of HIV infections]: Duodecim. 1996;112(2):135-44. Unique Identifier : AIDSLINE MED/20058125; Ranki A; Oulun yliopisto/OYKS:n iho- ja sukupuolitautien klinikka.
[Perinatal HIV infections]: Duodecim. 1996;112(2):145-9. Unique Identifier : AIDSLINE MED/20058126; Paavonen J; Helsingin yliopiston naistenklinikka.
[Intravenous drug abuse and the risk of HIV infections]: Duodecim. 1996;112(2):150-5. Unique Identifier : AIDSLINE MED/20058127; Leinikki P; Lillsunde P; Kantanen ML; Korte T; Seppala T; Kansanterveyslaitos, Helsinki.
Exposure to human immunodeficiency virus among healthcare workers in South Africa.: Int J Gynaecol Obstet. 2000 Jun;69(3):265-70. Unique Identifier : AIDSLINE MED/20314376; Gounden YP; Moodley J; Department of Obstetrics and Gynecology and MRC/UN Pregnancy; Hypertension Research Unit, University of Natal Medical School,; Durban, South Africa.; There have been no reports in the literature on occupational hazards of HIV in developing countries. The aim of this study was to evaluate occupational exposure to HIV in healthcare workers in Durban, South Africa . Individuals with occupational exposure to HIV were interviewed. Th
A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis.: FASEB J. 2000 Jul;14(10):1297-306. Unique Identifier : AIDSLINE MED/20336615; Manion MK; Su Z; Villain M; Blalock JE; University of Alabama at Birmingham, Department of Physiology and; Biophysics, 35294, USA.; Calmodulin (CaM), as well as other Ca(2+) binding motifs (i.e., EF hands), have been demonstrated to be Ca(2+) sensors for several ion channel types, usually resulting in an inactivation in a negative feedback manner. This provides a novel target for the regulation of such channels. We have designed peptides that inte
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.: FASEB J. 2000 Jul;14(10):1389-99. Unique Identifier : AIDSLINE MED/20336625; Cherepanov P; Pluymers W; Claeys A; Proost P; De Clercq E; Debyser Z; Rega Institute for Medical Research, K.U. Leuven, Belgium.; A synthetic gene encoding for HIV-1 integrase was designed to circumvent the intrinsic instability and the repressor elements present in the wild-type gene. High-level expression of HIV-1 integrase was obtained in various human cell lines independently of viral accessory proteins. A human 293T cell line was selected t
Experimental immune-mediated blepharoconjunctivitis in rats induced by immunization with ragweed pollen.: Graefes Arch Clin Exp Ophthalmol. 2000 Apr;238(4):346-51. Unique Identifier : AIDSLINE MED/20310982; Iwamoto H; Nishino K; Magone TM; Whitcup SM; Yoshida O; Yoshida H; Ozaki A; Fukushima A; Ueno H; Department of Ophthalmology, Kochi Medical School, Nankoku,; Japan.; BACKGROUND: A study was performed to compare the effects of immunization with ragweed pollen (RW) in two different adjuvants on the characteristics of a previously described model of experimental immune-mediated blepharoconjunctivitis (EC) in rats. METHODS: Lewis or Brown Norway (B
Antisense oligonucleotides for haematological malignancies.: Haematologica. 1999 Jun;84:19-22. Unique Identifier : AIDSLINE MED/20364902; Cotter FE; LRF Molecular Haematology Unit, Institute of Child Health,; London, UK. f.cotter@ich.ucl.ac.uk
Dendritic cell maturation and generation of immune responses.: Haematologica. 1999 Jun;84:23-5. Unique Identifier : AIDSLINE MED/20364903; Lanzavecchia A; Basel Institute for Immunology, Switzerland. Lanzavecchia@bii.ch
The role of chemokines and chemokine receptors in T cell priming and Th1/Th2-mediated responses.: Haematologica. 1999 Jun;84:28-31. Unique Identifier : AIDSLINE MED/20364905; Sallusto F; Basel Institute for Immunology, Switzerland. sallusto@bii.ch
Analysis of intestinal intraepithelial lymphocyte populations in experimental Trichinella spiralis infection of mice.: Folia Parasitol (Praha). 2000;47(1):55-9. Unique Identifier : AIDSLINE MED/20290614; Bozic F; Marinculic A; Durakovic E; Department of Pharmacology and Toxicology, Veterinary Faculty,; University of Zagreb, Croatia. Bozic@mavef.vef.hr; The potential role of intestinal intraepithelial lymphocytes (i-IELs) in the generation of host protective immunity after helminth infection was investigated using the Trichinella spiralis (Owen, 1835)/mouse model. In this study we found a significant rise of TCRgamma(delta)+ i-IELs (P
What are the immunologically active components of bacille Calmette-Guerin in therapy of superficial bladder cancer?: Int J Cancer. 2000 Sep 15;87(6):844-52. Unique Identifier : AIDSLINE MED/20413027; Zlotta AR; Van Vooren JP; Denis O; Drowart A; Daffe M; Lefevre P; Schandene L; De Cock M; De Bruyn J; Vandenbussche P; Jurion F; Palfliet K; Simon J; Schulman CC; Content J; Huygen K; Department of Urology, Erasme Hospital, University Clinics of; Brussels, Brussels, Belgium. azlotta@ulb.ac.be; The subcomponents of bacille Calmette-Guerin (BCG) involved in the mechanism of action of intravesical BCG immunotherapy used for prophylaxis of superficial bladder cancer recurrences have been poorly investigated. We purified various BCG subcomponents and analyzed in vitro their ability to enhance a Th1 polarized imm
[Nutritional therapy in palliative medicine]: Internist (Berl). 2000 Jul;41(7):641-7. Unique Identifier : AIDSLINE MED/20385546; Ollenschlager G; Medizinische Fakultat, Universitat zu Koln.; mail@ollenschlaeger.net
Trends in hospital antimicrobial prescribing after 9 years of stewardship.: J Antimicrob Chemother. 2000 Jun;45(6):913-7. Unique Identifier : AIDSLINE MED/20298770; Gould IM; Jappy B; Departments of Microbiology and Pharmacy, Aberdeen Royal; Infirmary, Aberdeen AB25 2ZN, Scotland, UK. i.m.gould@abdn.co.uk; Trends in antibiotic prescribing in Grampian have been monitored prospectively for 11 years from 1986 using computerized ward stock lists and laboratory data relating to all in-patient and out-patient treatments in all Grampian hospitals. The main outcome measures were the number of antibiotics available for routine a
Definition of an amino-terminal domain of the human T-cell leukemia virus type 1 envelope surface unit that extends the fusogenic range of an ecotropic murine leukemia virus.: J Biol Chem. 2000 Aug 4;275(31):23417-20. Unique Identifier : AIDSLINE MED/20378964; Kim FJ; Seiliez I; Denesvre C; Lavillette D; Cosset FL; Sitbon M; Institut de Genetique Moleculaire de Montpellier, IFR24,; CNRS-UMR5535, Paris, France.; Murine leukemia viruses (MuLV) and human T-cell leukemia viruses (HTLV) are phylogenetically highly divergent retroviruses with distinct envelope fusion properties. The MuLV envelope glycoprotein surface unit (SU) comprises a receptor-binding domain followed by a proline-rich region which modulates envelope conformati
Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities.: J Biol Chem. 2000 Aug 4;275(31):23736-44. Unique Identifier : AIDSLINE MED/20379008; Brelot A; Heveker N; Montes M; Alizon M; INSERM U.332, Institut Cochin de Genetique Moleculaire, 75014; and CNRS URA7627, CHU Pitie-Salpetriere, 75013 Paris, France.; CXCR4 is a G-coupled receptor for the stromal cell-derived factor (SDF-1) chemokine, and a CD4-associated human immunodeficiency virus type 1 (HIV-1) coreceptor. These functions were studied in a panel of CXCR4 mutants bearing deletions in the NH(2)-terminal extracellular domain (NT) or substitutions in the NT, the ex
Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry.: J Biol Chem. 2000 Aug 4;275(31):23774-82. Unique Identifier : AIDSLINE MED/20379013; Chabot DJ; Broder CC; Department of Microbiology and Immunology, Uniformed Services; University of the Health Sciences, Bethesda, Maryland 20814-4799,; USA.; CXCR4 and CCR5 are the principal coreceptors for human immunodeficiency virus type-1 (HIV-1) infection. Previously, mutagenesis of CXCR4 identified single amino acid changes that either impaired CXCR4 s coreceptor activity for CXCR4-dependent (X4) isolate envelope glycoproteins (Env) or expanded its activity, allowing
Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif.: J Biol Chem. 2000 Aug 4;275(31):23783-9. Unique Identifier : AIDSLINE MED/20379014; Friedler A; Friedler D; Luedtke NW; Tor Y; Loyter A; Gilon C; Department of Organic Chemistry, Institute of Chemistry, and the; Department of Biological Chemistry, The Alexander Silberman; Institute of Life Sciences, The Hebrew University of Jerusalem,; 91904, Jerusalem, Israel.; We have used the backbone cyclic proteinomimetics approach to develop peptides that functionally mimic the arginine-rich motif (ARM) of the HIV-1 Tat protein. This consensus sequence serves both as a nuclear localization signal (NLS) and as an RNA binding domain. Based on the NMR structure of Tat, we have designed and
The case for routine HIV screening before IVF treatment: a survey of UK IVF centre policies.: Hum Reprod. 2000 Aug;15(8):1657-61. Unique Identifier : AIDSLINE MED/20381048; Marcus SF; Avery SM; Abusheikha N; Marcus NK; Brinsden PR; Bourn Hall Clinic, Bourn, Cambridge, UK. sf.marcus@virgin.net; The case for routine human immunodeficiency virus (HIV) screening of all couples seeking assisted reproductive treatment is so strong that it should be made obligatory for all couples entering IVF programmes to be given information about HIV transmission, and offered testing. In August 1999, questionnaires regarding r
Determination of human immunodeficiency virus type 1 subtypes in Taiwan by vpu gene analysis.: J Clin Microbiol. 2000 Jul;38(7):2468-74. Unique Identifier : AIDSLINE GENBANK/AF220472; Lee CN; Wang WK; Fan WS; Twu SJ; Chen SC; Sheng MC; Chen MY; School and Graduate Institute of Medical Technology, Taipei,; Taiwan.; The genetic diversity of human immunodeficiency virus (HIV) type 1 (HIV-1) has been characterized mainly by analysis of the env and gag genes. Information on the vpu genes in the HIV sequence database is very limited. In the present study, the nucleotide sequences of the vpu genes were analyzed, and the genetic subtyp
Quantitation of varicella-zoster virus DNA in whole blood, plasma, and serum by PCR and electrochemiluminescence.: J Clin Microbiol. 2000 Jul;38(7):2568-73. Unique Identifier : AIDSLINE MED/20341550; de Jong MD; Weel JF; Schuurman T; Wertheim-van Dillen PM; Boom R; Section of Clinical Virology, Department of Medical Microbiology,; Academic Medical Centre, University of Amsterdam, Amsterdam, The; Netherlands. M.D.deJong@AMC.UVA.NL; We describe a highly sensitive assay for quantitation of varicella-zoster virus (VZV) DNA in blood, involving PCR amplification, solution hybridization with Tris-(2, 2 -bipyridine)-ruthenium(II) chelate-labeled probes, and measurement by electrochemiluminescence (ECL). Extraction and amplification efficiencies were mo
Comparison of two amplification technologies for detection and quantitation of human immunodeficiency virus type 1 RNA in the female genital tract. Division of AIDS Treatment Research Initiative 009 Study Team.: J Clin Microbiol. 2000 Jul;38(7):2665-9. Unique Identifier : AIDSLINE MED/20341566; Bremer J; Nowicki M; Beckner S; Brambilla D; Cronin M; Herman S; Kovacs A; Reichelderfer P; Rush Medical College, Chicago, Illinois 60612, USA.; jbremer@rush.edu; Human immunodeficiency virus type 1 (HIV-1) RNA levels in female genital tract and peripheral blood samples were compared using two commercial amplification technologies: the Roche AMPLICOR HIV-1 MONITOR test and either the Organon Teknika nucleic acid sequence-based amplification (NASBA-QT) assay or the NucliSens ass
18S ribosomal DNA-based PCR for diagnosis of Trichomonas vaginalis.: J Clin Microbiol. 2000 Jul;38(7):2683-7. Unique Identifier : AIDSLINE MED/20341569; Mayta H; Gilman RH; Calderon MM; Gottlieb A; Soto G; Tuero I; Sanchez S; Vivar A; Infectious Diseases Research Laboratory, Department of Pathology,; and A. B. PRISMA, Lima, Peru.; Trichomonas vaginalis remains the most common sexually transmitted parasite in the world and is considered a major risk factor in the transmission of the human immunodeficiency virus. A PCR technique using primers targeting a specific region of the 18S rRNA gene of T. vaginalis was developed. The PCR test was standard
Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya.: J Clin Microbiol. 2000 Jul;38(7):2688-95. Unique Identifier : AIDSLINE MED/20341570; Emery S; Bodrug S; Richardson BA; Giachetti C; Bott MA; Panteleeff D; Jagodzinski LL; Michael NL; Nduati R; Bwayo J; Kreiss JK; Overbaugh J; Division of Human Biology, Fred Hutchinson Cancer Research; Center, University of Washington, Seattle, Washington 98109, USA.; Accurate and sensitive quantification of human immunodeficiency virus type 1 (HIV-1) RNA has been invaluable as a marker for disease prognosis and for clinical monitoring of HIV-1 disease. The first generation of commercially available HIV-1 RNA tests were optimized to detect the predominant HIV-1 subtype found in Nor
Comparison of sequencing by hybridization and cycle sequencing for genotyping of human immunodeficiency virus type 1 reverse transcriptase.: J Clin Microbiol. 2000 Jul;38(7):2715-21. Unique Identifier : AIDSLINE GENBANK/AF156036; Hanna GJ; Johnson VA; Kuritzkes DR; Richman DD; Martinez-Picado J; Sutton L; Hazelwood JD; D'Aquila RT; Massachusetts General Hospital, Boston, Massachusetts 02129, USA.; The performances of two methods of nucleotide sequencing were compared for the detection of drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase (RT) in viruses isolated from highly RT inhibitor-experienced individuals. Of 11,677 amino acids deduced from population PCR products by bot
Assessment of viral loads in patients with chronic hepatitis C with AMPLICOR HCV MONITOR version 1.0, COBAS HCV MONITOR version 2.0, and QUANTIPLEX HCV RNA version 2.0 assays.: J Clin Microbiol. 2000 Jul;38(7):2722-5. Unique Identifier : AIDSLINE MED/20341575; Martinot-Peignoux M; Le Breton V; Fritsch S; Le Guludec G; Labouret N; Keller F; Marcellin P; Unite de Recherche INSERM U481, Centre de Recherche Claude; Bernard sur les Hepatites Virales and Service d'Hepatologie,; Hopital Beaujon, 92110 Clichy, France. martinot@bichat.inserm.fr; The correlation between response to antiviral therapy and pretreatment viral load in patients with chronic hepatitis C has prompted the development of quantitative assays to measure viral load. The aim of our study was to assess the clinical relevance of the newly developed semiautomated PCR system COBAS HCV MONITOR v
Early virological failure in naive human immunodeficiency virus patients receiving saquinavir (soft gel capsule)-stavudine-zalcitabine (MIKADO trial) is not associated with mutations conferring viral resistance.: J Clin Microbiol. 2000 Jul;38(7):2726-30. Unique Identifier : AIDSLINE MED/20341576; Mouroux M; Yvon-Groussin A; Peytavin G; Delaugerre C; Legrand M; Bossi P; Do B; Trylesinski A; Diquet B; Dohin E; Delfraissy JF; Katlama C; Calvez V; Department of Virology, Pitie-Salpetriere Hospital, Paris,; France.; The MIKADO trial was designed to evaluate the efficacy of stavudine-zalcitabine-saquinavir (soft gel capsule) [d4T-ddC-SQV(SGC)] in 36 naive patients (-3.3 log(10) units at week 24 [W24]). Among the 29 patients remaining on d4T-ddC-SQV(SGC) until W24, 10 harbored a virological failure (viral load of >200 copies/ml at
Detection of human cytomegalovirus DNA by real-time quantitative PCR.: J Clin Microbiol. 2000 Jul;38(7):2734-7. Unique Identifier : AIDSLINE MED/20341578; Nitsche A; Steuer N; Schmidt CA; Landt O; Ellerbrok H; Pauli G; Siegert W; Klinik fur Innere Medizin m.S. Hamatologie und Onkologie,; Charite-Campus Virchow Klinikum, Humboldt Universitat zu; Berlin, Berlin, Germany.; A real-time PCR assay was developed to quantify human cytomegalovirus ( CMV ) DNA. This assay was used to demonstrate a higher CMV DNA load in plasma of bone marrow transplant patients than in that of blood donors. The CMV load
Survey for the presence and distribution of human herpesvirus 8 in healthy brain.: J Clin Microbiol. 2000 Jul;38(7):2772-3. Unique Identifier : AIDSLINE MED/20341590; Chan PK; Ng HK; Cheung JL; Cheng AF; Department of Microbiology, The Chinese University of Hong Kong,; Prince of Wales Hospital, Shatin, Hong Kong SAR, China.; paulkschan@cuhk.edu.hk; Brain tissues from both sides of the cerebellum and frontal, temporal, parietal, and occipital lobes were collected postmortem from 30 patients for human herpesvirus 8 (HHV-8) detection by PCR. Overall, 42 of 300 (14.0%) samples were positive, with similar rates for each position. Nineteen patients (63.3%) were positi
A method of analyzing improvisations in music therapy.: J Music Ther. 2000 Summer;37(2):147-67. Unique Identifier : AIDSLINE MED/20430991; Lee C; Wilfrid Laurier University.
Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents.: J Med Chem. 2000 Jul 27;43(15):2915-21. Unique Identifier : AIDSLINE MED/20412512; El-Subbagh HI; Abu-Zaid SM; Mahran MA; Badria FA; Al-Obaid AM; Department of Pharmaceutical Chemistry, College of Pharmacy, King; Saud University, Riyadh, Saudi Arabia. subbagh@yahoo.com; A new series of 3,5-bis(arylidene)-4-piperidones, as chalcone analogues carrying variety of aryl and heteroaryl groups, pyrazolo[4,3-c]pyridines, pyridolo[4,3-c]pyrimidines, and pyrido[4,3-c]-pyridines, carrying an arylidene moiety, and a series of pyrano[3,2-c]pyridines, as flavone and coumarin isosteres, were synthe
Widely used spermicide may increase, not decrease, risk of HIV transmission [news]: JAMA. 2000 Aug 23-30;284(8):949. Unique Identifier : AIDSLINE MED/20404121; Stephenson J
Breastfeeding in women with HIV [letter; comment]: JAMA. 2000 Aug 23-30;284(8):956; discussion 956-7. Unique Identifier : AIDSLINE MED/20404129; Bulterys M
Breastfeeding in women with HIV [letter; comment]: JAMA. 2000 Aug 23-30;284(8):956-7. Unique Identifier : AIDSLINE MED/20404127; Coutsoudis A; Coovadia HM; Pillay K; Kuhn L
Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor.: Kidney Int. 2000 Aug;58(2):607-17. Unique Identifier : AIDSLINE MED/20377792; Tokizawa S; Shimizu N; Hui-Yu L; Deyu F; Haraguchi Y; Oite T; Hoshino H; Department of Virology and Preventive Medicine, Gunma University; School of Medicine, Japan.; BACKGROUND: Mesangial cells are an important component of the glomerulus. Dysfunction of mesangial cells is thought to be involved in the development of human immunodeficiency virus type 1 (HIV-1)-associated nephropathy (HIVAN). HIVAN is a structural renal failure frequently observed in patients with acquired immune d
Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation.: Kidney Int. 2000 Aug;58(2):674-83. Unique Identifier : AIDSLINE MED/20377798; Shankland SJ; Eitner F; Hudkins KL; Goodpaster T; D'Agati V; Alpers CE; Department of Medicine, Division of Nephrology, University of; Washington School of Medicine, Seattle 98195-6521, USA.; stuarts@u.washington.edu; BACKGROUND: Normal human podocytes are terminally differentiated and quiescent cells. It is not known why podocytes fail to proliferate in response to most forms of injury. Proliferation is regulated by cell cycle proteins and their inhibitors. The Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27,
Influence of cold-storage conditions on renal function of autotransplanted large pig kidneys.: Kidney Int. 2000 Aug;58(2):838-50. Unique Identifier : AIDSLINE MED/20377817; Goujon JM; Vandewalle A; Baumert H; Carretier M; Hauet T; Unite de Transplantation Experimentale, Departement de; Genetique Animale, Institut National de Recherche Agronomique,; Surgeres, France.; BACKGROUND: The consequences of ischemia/reperfusion injury (IRI) on delayed graft function (DGF) and graft survival for kidney recipients remain a matter of debate. Several strategies have been proposed to reduce IRI. We have shown that adding the anti-ischemic drug trimetazidine (TMZ) to different preservation solut
Disruption of the IFN-gamma cytokine network in chronic lymphocytic leukemia contributes to resistance of leukemic B cells to apoptosis.: Leuk Res. 2000 Jul;24(7):611-21. Unique Identifier : AIDSLINE MED/20327798; Zaki M; Douglas R; Patten N; Bachinsky M; Lamb R; Nowell P; Moore J; Department of Pathology and Laboratory Medicine, School of; Medicine, University of Pennsylvania, Philadelphia, PA; 19104-6082, USA.; Recent evidence indicates that the slowly expanding population of CD5+ B cells that characterizes chronic lymphocytic leukemia (CLL) results primarily from defects in responses to cytokines that regulate apoptosis (e.g. I1-4, TGF-beta, IFN-alpha, IFN-gamma). We have now demonstrated not only that the enhanced anti-apo
Recalcitrant pyoderma gangrenosum treated with thalidomide.: Mayo Clin Proc. 2000 Aug;75(8):842-4. Unique Identifier : AIDSLINE MED/20398937; Federman GL; Federman DG; Department of Dermatology, Yale University School of Medicine,; New Haven, CT 06516, USA.; Pyoderma gangrenosum is a painful, noninfectious, ulcerating skin disorder often associated with systemic disease. Thalidomide has been used to treat many inflammatory dermatologic conditions and has been reintroduced in the United States to treat immune-modulated diseases such as pyod
Immunopathology of cardiomyopathy in the experimental Chagas disease.: Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:257-62. Unique Identifier : AIDSLINE MED/20143947; Soares MB; Santos RR; Laboratorio de Imunofarmacologia, Centro de Pesquisas Goncalo; Moniz, Fiocruz, Salvador, Brasil.; The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During
Evolution on the immunopathology of Chagas disease.: Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:277-8. Unique Identifier : AIDSLINE MED/20143951; Sadigursky M; Faculdade de Medicina, Universidade Federal da Bahia, Salvador,; BA, 40140-001, Brasil.
Etiological treatment for infection by Trypanosoma cruzi.: Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:337-9. Unique Identifier : AIDSLINE MED/20143969; Amato Neto V; Laboratorio de Parasitologia, Instituto de Medicina Tropical de; Sao Paulo, Brasil. mamtonet@usp.br
Plague as HIV vaccine adjuvant.: Med Hypotheses. 2000 Jun;54(6):1003-4. Unique Identifier : AIDSLINE MED/20327837; Altschuler EL; Brain and Perception Laboratory, University of California, San; Diego, La Jolla 92093-0109, USA. elaltsch@sdcc3.ucsd.edu; Individuals homozygous for a 32-basepair deletion mutation (null mutation) in CCR5, a chemokine receptor, are nearly immune to developing HIV infection. Recently based on molecular dating evidence it has been proposed that the bacterium Yersinia pestis, cause of plague, may have been the selective pressure which selec
Sampling irregularities, or why the present estimate for risk of HIV casual transmission is probably an underestimate.: Med Hypotheses. 2000 Jun;54(6):1008-18. Unique Identifier : AIDSLINE MED/20327839; Razel M; School of Education, Bar-IIan University, Ramat-Gan, Israel.; Updating the list of casual transmission studies yielded a minor revision of the recently reported estimate of the risk of HIV casual household transmission, estimating it as 0.3% per year of contact. A meta-analysis of the studies used to calculate this risk indicated that the estimated risk is probably an underestim
Specific toxins destabilize virus inhibitors (e.g. AIDS viruses).: Med Hypotheses. 2000 Jun;54(6):917-8. Unique Identifier : AIDSLINE MED/20327822; Reid G; There are two approaches to the study of viral infections - the A-Z hypothesis of Sprietsma involving thiol-zinc inhibition of protease activation in the virus coat, and the activity of toxins in depleting the cell of thiols, or the activity of toxins activating (not detoxifying) the mixed function oxidase (MFO) syste
Antibodies to antigens of Histoplasma, Blastomyces and Candida in HIV patients and carriers in Nigeria.: Mycoses. 2000;43(5):173-5. Unique Identifier : AIDSLINE MED/20404615; Muotoe-Okafor FA; Gugnani HC; Gugnani A; Okafor G; Department of Microbiology, University of Nigeria, Nsukka,; Nigeria.; Serum samples from 60 subjects with confirmed HIV-1 infection including 28 AIDS patients and 32 carriers were examined by immunodiffusion for precipitating antibodies to antigens of Histoplasma, Blastomyces and Candida. Seven of the subjects, four patients and three carriers, showed antibodies to histoplasmin prepared
Case reports. Disseminated cryptococcoses without cryptococcal antigen detection [letter]: Mycoses. 2000;43(5):203-7. Unique Identifier : AIDSLINE MED/20404621; Tintelnot K; Adler S; Bergmann F; Schonherr K; Seibold M; During the last decade cryptococcoses were most frequently diagnosed in AIDS patients, where serologically high amounts of glucoronoxylomannan (GXM) were detectable. Disseminated cryptococcoses without cryptococcal antigen detection is unusual. Between August and October 1998 disseminated cryptococcoses were diagnosed
Kaposi's sarcoma [letter]: N Engl J Med. 2000 Aug 24;343(8):582-3; discussion 583-4. Unique Identifier : AIDSLINE MED/20397928; Mazzone A; Ottini E; Paulli M
Change in natural history of opportunistic infections in HIV-infected patients [editorial; comment]: Neth J Med. 2000 Jul;57(1):1-3. Unique Identifier : AIDSLINE MED/20323557; Schneider MM
HIV-infected patient with a Rhodococcus equi pneumonia [see comments]: Neth J Med. 2000 Jul;57(1):25-9. Unique Identifier : AIDSLINE MED/20323562; Hulsewe-Evers HP; Jansveld CA; Jansz AR; Schneider MM; Bravenboer B; Department of Internal Medicine, Academic Hospital, Maastricht,; The Netherlands.; The case history of a HIV patient with a pulmonary infect of Rhodococcus equi is presented. He recovered after prolonged treatment with antibiotics and lobectomy. The Rhodococcus equi infection was the presenting symptom of his impaired immune status caused by HIV infection.
HIV-Associated nephropathy: is it going to disappear? [letter]: Nephron. 2000 Jun;85(2):178-9. Unique Identifier : AIDSLINE MED/20327854; Marques LP; Rioja LS; Department of Medicine, University of Rio de Janeiro, Brazil.
[Evaluation of the effect of early and massive tritherapy on the expression of cellular factors potentially implicated in antiretroviral therapy resistance]: Pathol Biol (Paris). 2000 Jun;48(5):490-4. Unique Identifier : AIDSLINE MED/20406395; Jorajuria S; Clayette P; Dereuddre-Bosquet N; Larghero J; Thiebot H; Neildez O; Vaslin B; Le Grand R; Dormont D; Service de neurovirologie, DSV/DRM, CEA, CRSSA,; Fontenay-aux-Roses, France.; Treatment of the human immunodeficiency virus (HIV) is restricted by therapeutic escape. The biological mechanisms of this chemoresistance rely notably on the modulation of cell kinase and P-glycoprotein (P-gp) expression. In this study, we investigated, in cynomolgus macaques, the roles of SHIV89.6P infection and of
[Mycobacterium avium complex disease in HIV seropositive patients: incidence and risk factors before and after the introduction of highly active antiretroviral treatments. Clinical Epidemiology Group of the Information and Care Center for Human Immunodeficiency]: Pathol Biol (Paris). 2000 Jun;48(5):495-504. Unique Identifier : AIDSLINE MED/20406396; Mary-Krause M; Rabaud C; Jouan M; Obadia M; de la Blanchardiere A; Raffi F; May T; Inserm SC4, faculte de medecine Saint-Antoine, Paris, France.; The objective of this study was to determine the risk factors of the first occurrence of Mycobacterium avium complex disease (MAC) infection among human immunodeficiency virus (HIV)-infected subjects during two different time periods: before and after the introduction of protease inhibitor (respectively, period 1: 1 J
[Fatal lactic acidosis in a patient infected by HIV and treated with stavudine and didanosine]: Pathol Biol (Paris). 2000 Jun;48(5):505-7. Unique Identifier : AIDSLINE MED/20406397; Megarbane B; Goldgran-Toledano D; Guerin JM; Baud F; CHU Lariboisiere, Paris, France.; We report a case of severe lactic acidosis in an human immunodeficiency virus (HIV)-infected patient treated with combination regimen of stavudine , didanosine and nevirapine . Antiretr
[Conditions of "thymidine analog mutations" (TAMs) in naive patients treated with different combinations of d4T]: Pathol Biol (Paris). 2000 Jun;48(5):508-12. Unique Identifier : AIDSLINE MED/20406398; Mouroux M; Izopet J; Descamps D; Delaugerre C; Yvon-Groussin A; Angleraud F; Coutellier A; Bonmarchand M; Valantin MA; Matheron S; Agut H; Katlama C; Brun-Vezinet F; Calvez V; Laboratoire de virologie, hopital Pitie-Salpetriere, Paris,; France.; Recently, d4T /ddI combination has been associated with the selection of thymidine analogue mutations (TAMs) in 50% of patients with a detectable viral load after 6 to 12 months of this bi-therapy (ALBI, STADI and BMS A1460 tests). We evaluated the rat
[Antiretroviral ant anti-inflammatory properties of a novel platelet activation factor antagonist, PMS-601]: Pathol Biol (Paris). 2000 Jun;48(5):513-9. Unique Identifier : AIDSLINE MED/20406399; Martin M; Serradji N; Dereuddre-Bosquet N; Bensaid O; Fichet G; Lamouri A; Heymans F; Clayette P; Godfroid JJ; Dormont D; CEA, service de neurovirologie, DSV/DRM, CRSSA, institut; Paris-Sud sur les cytokines, Fontenay aux Roses, Paris.; The platelet-activating factor (PAF) plays a major role in neuropathogenesis associated with human immunodeficiency virus (HIV) infection by enhancing the inflammatory syndrome and viral replication, particularly in cells of the macrophage lineage, and its neurotoxic properties. We therefore evaluated the ability of P
Ultrastructure of the polymorphonuclear leucocytes in human immunodeficiency virus infection.: Pathology. 2000 May;32(2):119-25. Unique Identifier : AIDSLINE MED/20299871; Battaglione VJ; Fischer F; Michiels JF; Rossi B; Hofman PM; Department of Pathology, University of Nice, France.; The ultrastructure of polymorphonuclear leucocytes (PMNL) was studied in 16 patients infected with the human immunodeficiency virus (HIV). PMNL were isolated from HIV-infected patients with CD4+ lymphocytes counts > 200/mm3 (without signs of active infection) (n = 12) (group 1), or
Analysis of type T1 and T2 cytokines in patients with prostate cancer.: Prostate. 2000 Sep 1;44(4):271-4. Unique Identifier : AIDSLINE MED/20409222; Filella X; Alcover J; Zarco MA; Beardo P; Molina R; Ballesta AM; Unit for Cancer Research, Department of Clinical Biochemistry,; Institut d'Investigacions Biomediques August Pi i Sunyer,; Hospital Clinic, Barcelona, Spain. xfiella@clinic.ub.es; BACKGROUND: It has been proposed that a dysregulation in the balance between type T1 ( IL-2 , IFN-gamma) and type T2 (IL-4, IL-10) cytokines may be implicated in the development of cancer. METHODS: We determined the expression of IL-2, IL-4, IL-10, and IFN-gamma in CD4 a
Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA.: Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8955-60. Unique Identifier : AIDSLINE MED/20381318; Michienzi A; Cagnon L; Bahner I; Rossi JJ; Department of Molecular Biology, Beckman Research Institute of; the City of Hope, and Graduate School of Biological Sciences,; City of Hope, Duarte, CA 91010-3011, USA.; The HIV regulatory proteins Tat and Rev have a nucleolar localization property in human cells. However, no functional role has been attributed to this localization. Recently it has been demonstrated that expression of Rev induces nucleolar relocalization of some protein factors involved in Rev export. Because the func
Energetics of the HIV gp120-CD4 binding reaction.: Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9026-31. Unique Identifier : AIDSLINE MED/20381330; Myszka DG; Sweet RW; Hensley P; Brigham-Burke M; Kwong PD; Hendrickson WA; Wyatt R; Sodroski J; Doyle ML; Department of Oncological Sciences, Huntsman Cancer Institute,; University of Utah, Salt Lake City, UT 84112, USA.; dmyszka@hci.utah.edu; HIV infection is initiated by the selective interaction between the cellular receptor CD4 and gp120, the external envelope glycoprotein of the virus. We used analytical ultracentrifugation, titration calorimetry, and surface plasmon resonance biosensor analysis to characterize the assembly state, thermodynamics, and k
Selective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokine.: Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9162-7. Unique Identifier : AIDSLINE MED/20381354; Cota M; Mengozzi M; Vicenzi E; Panina-Bordignon P; Sinigaglia F; Transidico P; Sozzani S; Mantovani A; Poli G; AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute,; 20132 Milan, Italy.; Macrophage-derived chemokine (MDC) has been reported to inhibit different HIV-1 strains in activated peripheral blood mononuclear cells (T cell blasts), although other investigators have not confirmed these findings. Here we demonstrate that MDC inhibits the replication of CCR5-dependent (R5) HIV-1(BaL) in monocyte-de
Effect of antimicrobial and anti-inflammatory medications on the sense of taste.: Physiol Behav. 2000 Jun 1-15;69(4-5):413-24. Unique Identifier : AIDSLINE MED/20375122; Schiffman SS; Zervakis J; Westall HL; Graham BG; Metz A; Bennett JL; Heald AE; Department of Psychiatry, Box 3259, Duke University Medical; School, Durham, NC 27710, USA. sss@acpub.duke.edu; Elderly individuals and HIV-infected patients have a disproportionate number of taste complaints relative to the general population, and these taste alterations are correlated with the use of medications. Clinical reports of taste disorders have been associated with many drugs, including antimicrobial and anti-inflamm
[The role of inflammation in the modulation of bronchial hyperreactivity. Potential therapeutic applications]: Rev Mal Respir. 2000 Jun;17(2 Pt 2):555-8. Unique Identifier : AIDSLINE MED/20395027; Kips JC; Departement des Maladies Respiratoires, Hopital Universitaire,; Gand, Belgique. johan.kips@rug.ac.be; The exact functional contribution of the various inflammatory cells, mediators, cytokines and growth factors present in asthmatic airways to bronchial hyperresponsiveness remains to be fully established. Gene knock-out in vivo animal models can provide valuable information in this respect. Obviously, the closer the an
Preliminary studies on feline coronavirus distribution in naturally and experimentally infected cats.: Unique Identifier : AIDSLINE MED/20342285 P; Kiss I; Kecskemeti S; Tanyi J; Klingeborn B; Belak S
[Drug-addicted prisoners: seroprevalence of human immunodeficiency virus and hepatitis B and C virus soon after the marketing of buprenorphine]: Rev Med Interne. 2000 Jun;21(6):505-9. Unique Identifier : AIDSLINE MED/20366878; Claudon-Charpentier A; Hoibian M; Glasser P; Lalanne H; Pasquali JL; Service pharmacie, hopital de Hautepierre, Hopitaux; universitaires de Strasbourg, France.; PURPOSE: Considering the importance to public health and the frequency with which drug addicts are imprisoned, we studied the prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), as well as drug addiction of patients admitted to the Elsau prison in Strasbourg (
[Development of a predictive model for respiratory isolation of patients suspected of having pulmonary tuberculosis]: Rev Med Interne. 2000 Jun;21(6):533-41. Unique Identifier : AIDSLINE MED/20366882; Tattevin P; Egmann G; Casalino E; Fleury L; Ruel M; Bouvet E; Clinique de reanimation des maladies infectieuses, hopital; Bichat-Claude-Bernard, Paris, France.; INTRODUCTION: As numerous nosocomial outbreaks of pulmonary tuberculosis have been reported during the last two decades, prompt identification and effective isolation of contagious patients should be made a priority in tuberculosis control policies. There is a need to develop a predictive model which would allow promp
AIDS research. The odd intersection of HIV and scrub typhus [news]: Unique Identifier : AIDSLINE MED/20418918; Cohen J
Current status of hemophilia patients and recombinant coagulation factor concentrates in Japan.: Semin Thromb Hemost. 2000;26(1):29-32. Unique Identifier : AIDSLINE MED/20263028; Fukutake K; Department of Clinical Pathology, Tokyo Medical University,; Japan. k-fukuta@qa2.so-net.ne.jp; The first recombinant factor VIII concentrate was introduced in 1987 to treat hemophilia A patients, and the product was licensed in the United States in 1992. More than 10 years have passed since the recombinant products have been used for treatment of hemophilia A. The new therapeuti
Acquired immunodeficiency syndrome malignancies.: Semin Oncol. 2000 Aug;27(4):389-491. Unique Identifier : AIDSLINE MED/20405297
The epidemiology of acquired immunodeficiency syndrome malignancies.: Semin Oncol. 2000 Aug;27(4):390-401. Unique Identifier : AIDSLINE MED/20405298; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD, USA.; The acquired immunodeficiency syndrome (AIDS) results in an extraordinary increase in the risk of two malignancies: Kaposi s sarcoma (KS; relative risk [RR], >10,000) and B-cell non-Hodgkin s lymphoma (NHL; RR, >100). KS appears to result from uncontrolled expression of latency gen
Transplantation-related lymphoproliferative disorder: a model for human immunodeficiency virus-related lymphomas.: Semin Oncol. 2000 Aug;27(4):402-8. Unique Identifier : AIDSLINE MED/20405299; Swinnen LJ; Division of Hematology/Oncology, Loyola University Chicago,; Maywood, IL, USA.; Post-transplant lymphoproliferative disorders (PTLD) share many of the features of human immunodeficiency virus (HIV)-related lymphomas, although important differences exist. PTLD ranges from hyperplastic lesions to aggressive lymphoma or multiple myeloma histology. The coexistence of multiple clones, and the strong a
Kaposi's sarcoma-associated herpes virus and acquired immunodeficiency syndrome-related malignancy.: Semin Oncol. 2000 Aug;27(4):409-19. Unique Identifier : AIDSLINE MED/20405300; Cannon M; Cesarman E; Department of Medicine, Weill Medical College of Cornell; University, New York, NY 10021, USA.; Kaposi s sarcoma-associated herpes virus (KSHV), also known as human herpes virus-8 (HHV-8), is a recently described gamma-herpes virus that has been etiologically linked to two different acquired immunodeficiency syndrome (AIDS)-related malignancies by strong epidemiologic and pathologic evidence. Infection been show
The role of human immunodeficiency virus-I in the pathogenesis of acquired immunodeficiency syndrome-related Kaposi's sarcoma: the importance of an inflammatory and angiogenic milieu.: Semin Oncol. 2000 Aug;27(4):420-3. Unique Identifier : AIDSLINE MED/20405301; Dezube BJ; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, MA 02215, USA.; People infected with human immunodeficiency virus type-I (HIV-I) have an increased incidence of Kaposi s sarcoma (KS) and HIV-I infection alters the natural history of KS. The potent trans-activator HIV-I protein Tat plays a major role in the pathogenesis of acquired immunodeficiency syndrome (AIDS)-related KS. Among
Acquired immunodeficiency syndrome-related Kaposi's sarcoma: clinical features, staging, and treatment.: Semin Oncol. 2000 Aug;27(4):424-30. Unique Identifier : AIDSLINE MED/20405302; Dezube BJ; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, MA 02215, USA.; The clinical course of acquired immunodeficiency syndrome (AIDS)-related Kaposi s sarcoma (KS) is highly variable, ranging from minimal stable disease to explosive growth. Although KS is primarily a cutaneous disease, extracutaneous spread is common; the oral cavity, gastrointestinal (GI) tract, lungs, and lymph nodes
The molecular basis of acquired immunodeficiency syndrome-related lymphomagenesis.: Semin Oncol. 2000 Aug;27(4):431-41. Unique Identifier : AIDSLINE MED/20405303; Gaidano G; Capello D; Carbone A; Department of Medical Sciences, Amedeo Avogadro University of; Eastern Piedmont, Novara, Italy.; Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal center (GC) or post-GC B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host,
Acquired immunodeficiency syndrome-related lymphoma: clinical aspects.: Semin Oncol. 2000 Aug;27(4):442-53. Unique Identifier : AIDSLINE MED/20405304; Levine AM; Division of Hematology, Keck School of Medicine, University of; Southern California, Los Angeles 90033, USA.; While the widespread use of highly active antiretroviral therapy (HAART) has led to substantial decreases in the incidence of opportunistic infections and Kaposi s sarcoma, a major decrease in lymphoma has not yet occurred. Patients with acquired immunodeficiency syndrome (AIDS)-related lymphoma present with widesprea
Acquired immunodeficiency syndrome-related lymphomas: future directions.: Semin Oncol. 2000 Aug;27(4):454-62. Unique Identifier : AIDSLINE MED/20405305; Porcu P; Caligiuri MA; Division of Hematology/Oncology, The Ohio State University,; Columbus 43210, USA.; Despite some exciting new leads, human immunodeficiency virus-I (HIV-I)-related non-Hodgkin s lymphoma (HIV-NHL) remains a fatal malignancy for the vast majority of patients. The use of highly active antiretroviral therapy (HAART) has not produced a fall in the incidence of HIV-NHL
Invasive and preinvasive cervical neoplasia in human immunodeficiency virus-infected women.: Semin Oncol. 2000 Aug;27(4):463-70. Unique Identifier : AIDSLINE MED/20405306; Robinson W 3rd; The Don and Sybil Harrington Cancer Center, Amarillo, TX, USA.; An association between human immunodeficiency virus (HIV) infection and cervical neoplasia in women has recently been recognized. Cervical cancer was designated as a diagnostic criteria for acquired immunodeficiency syndrome (AIDS) in HIV-infected women in 1993. The two conditions share a number of risk factors, inclu
Anal squamous intraepithelial lesions in human immunodeficiency virus-positive men and women.: Semin Oncol. 2000 Aug;27(4):471-9. Unique Identifier : AIDSLINE MED/20405307; Palefsky JM; Department of Laboratory Medicine, University of California, San; Francisco 94143, USA.; Studies from the era prior to the introduction of highly active antiretroviral therapy (HAART) have shown that the prevalence of anal human papillomavirus (HPV) infection and anal squamous intraepithelial lesions (ASIL) was very high among human immunodeficiency virus (HIV)-positive homosexual men, and to a lesser ext
Human immunodeficiency virus-associated Hodgkin's disease.: Semin Oncol. 2000 Aug;27(4):480-8. Unique Identifier : AIDSLINE MED/20405308; Spina M; Vaccher E; Nasti G; Tirelli U; Division of Medical Oncology A, National Cancer Institute,; Aviano, Italy.; Hodgkin s disease represents the most common type of non-acquired immunodeficiency virus (AIDS)-defining tumor that occurs in the human immunodeficiency virus (HIV)-positive population. More than 300 cases of Hodgkin s disease in HIV-infected individuals have been reported, mainly from the European countries (ie,
Using DNA fingerprinting to detect transmission of Mycobacterium tuberculosis among AIDS patients in two health-care facilities in Puerto Rico.: Unique Identifier : AIDSLINE MED/20417498; Hennessey KA; Schulte JM; Valway SE; Joglar OT; Rios N; Sheppard JD; Onorato IM; BACKGROUND: Fourteen cases of tuberculosis (TB) in Puerto Rico ,
Disseminated osteoarticular sporotrichosis: treatment in a patient with acquired immunodeficiency syndrome.: South Med J. 2000 Aug;93(8):803-6. Unique Identifier : AIDSLINE MED/20417504; Edwards C; Reuther WL 3rd; Greer DL; Department of Dermatology, Louisiana State University Medical; Center, New Orleans 70112, USA.; We report a case of multiple skin lesions, lymphadenopathy, and osteoarticular sporotrichosis in a man infected with human immunodeficiency virus (HIV). He subsequently died of tuberculosis after successful treatment for osteoarticular sporotrichosis with amphotericin B. We describe the unusual histopathology in disse
Esophageal ulcer caused by cytomegalovirus: resolution during combination antiretroviral therapy for acquired immunodeficiency syndrome.: South Med J. 2000 Aug;93(8):818-20. Unique Identifier : AIDSLINE MED/20417509; Monkemuller KE; Wilcox CM; Department of Medicine, University of Alabama at Birmingham,; 35294-0007, USA.; A 36-year-old man with a 5-year history of untreated human immunodeficiency virus (HIV) infection had odynophagia for 14 days. Fifteen days earlier, he had begun taking trimethoprim-sulphamethoxazole and combination antiretroviral therapy that included lamivudine, zidovudine, and nelfinavir. He had no history of oppor
Reducing mother-to-child transmission of HIV [letter]: S Afr Med J. 2000 Apr;90(4):322, 324. Unique Identifier : AIDSLINE MED/20413771; Bolton KD; Hofmeyr GJ
Hanging in there for a new TB drug [news]: Unique Identifier : AIDSLINE MED/20413776; Bateman C
Post-exposure prophylaxis for HIV.: S Afr Med J. 2000 Apr;90(4):346-51. Unique Identifier : AIDSLINE MED/20413777; Gathiram V
A review of maternal deaths in South Africa during 1998. National Committee on Confidential Enquiries into Maternal Deaths.: S Afr Med J. 2000 Apr;90(4):367-73. Unique Identifier : AIDSLINE MED/20413783; OBJECTIVE: To document the prevalence and causes of maternal mortality and to identify avoidable factors, missed opportunities and substandard care related to these deaths. METHOD: Maternal deaths are notifiable; when a maternal death occurs a maternal death notification form is filled in and sent to the provincial Ma
Drug-resistant pulmonary tuberculosis in a cohort of southern African goldminers with a high prevalence of HIV infection.: S Afr Med J. 2000 Apr;90(4):381-6. Unique Identifier : AIDSLINE MED/20413786; Murray J; Sonnenberg P; Shearer S; Godfrey-Faussett P; Department of Health, University of the Witwatersrand,; Johannesburg. jmurray@ncoh.pwv.gov.za; OBJECTIVES: To determine rates of drug resistance to Mycobacterium tuberculosis and associated risk factors, including HIV infection. DESIGN: Prospective cohort study of patients with pulmonary tuberculosis. SETTING: The study population comprised 28,522 men working on four goldmines in Westonaria, Gauteng. Health car
Nondepleting anti-CD4 but not anti-CD8 antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1, 3-galactosyl-transferase knock-out mice.: Transplant Proc. 2000 Aug;32(5):1005. Unique Identifier : AIDSLINE MED/20396469; Chong AS; Ma L; Yin D; Shen J; Blinder L; XiuLong X; Williams J; Byrne G; Diamond L; Logan J; Section of Transplantation, Department of General Surgery, Rush; Presbyterian St Luke's Medical Center, Chicago, Illinois 60612,; USA.
Effect of B cell/plasma cell depletion or suppression on anti-Gal antibody in the baboon.: Transplant Proc. 2000 Aug;32(5):1009. Unique Identifier : AIDSLINE MED/20396471; Basker M; Alwayn IP; Treter S; Harper D; Buhler L; Andrews D; Thall A; Lambrigts D; Awwad M; White-Scharf M; Sachs DH; Cooper DK; Transplantation Biology Research Center, Massachusetts General; Hospital/Harvard Medical School, Boston, Massachusetts 02129,; USA.
Partial deletion of donor T cells in the recipient thymus in fully xenogeneic mouse-to-rat chimeras.: Transplant Proc. 2000 Aug;32(5):1039. Unique Identifier : AIDSLINE MED/20396489; Mohiuddin MM; Qian X; Qin Y; DiSesa VJ; Department of Cardiovascular-Thoracic Surgery, Rush Presbyterian; Medical Center, Chicago, Illinois, USA. mmohiudd@rush.edu
T cells interacting with the alpha-Gal epitope: studies in alpha1, 3Galactosyltransferase knock-out mice.: Transplant Proc. 2000 Aug;32(5):921-3. Unique Identifier : AIDSLINE MED/20396421; Tanemura M; Galili U; Departments of Cardiovascular-Thoracic Surgery and Immunology,; Rush University, Chicago, Illinois 60612, USA.
Surrogate tolerogenesis: possible pretransplant induction of accommodation of pig xenografts.: Transplant Proc. 2000 Aug;32(5):994-5. Unique Identifier : AIDSLINE MED/20396465; Beschorner W; Sudan D; Yang T; Radio S; Stammers A; Johnson N; Shearon C; Kuszynski C; Dixon RS; Matamoros A; Langnas A; Ximerex, Inc, Omaha, Nebraska 68116-2461, USA.
The health worker and HIV in high-incidence poor countries: Part 1--HIV and the health worker.: Trop Doct. 2000 Jul;30(3):175-7. Unique Identifier : AIDSLINE MED/20360940; Cairns J; St Francis' Hospital, Katete, Zambia. JamesCairns@compuserve.com
Community informed consent for HIV testing [letter; comment]: Trop Doct. 2000 Jul;30(3):189. Unique Identifier : AIDSLINE MED/20360951; Prabha A
Safety of injections--facts and figures [news]: Trop Doct. 2000 Jul;30(3):190. Unique Identifier : AIDSLINE MED/20360953
Debt relief policies could be fuelling African AIDS epidemic, warns new report [news]: Trop Doct. 2000 Jul;30(3):191. Unique Identifier : AIDSLINE MED/20360954
Chemokines and viruses: the dearest enemies.: Virology. 2000 Aug 1;273(2):228-40. Unique Identifier : AIDSLINE MED/20377921; Lusso P; Unit of Human Virology, DIBIT-San Raffaele Scientific Institute,; Via Olgettina n. 58, Milan, 20132, Italy. paulo.lusso@hsr.it; The relation between viruses and the chemokine system is characterized by a complex blend of enmity and attraction. Chemokines are key regulators of innate and adaptive immune responses against invading microorganisms, including viruses. They act not only as immune system traffic officers, controlling leukocyte migr
LuSIV cells: a reporter cell line for the detection and quantitation of a single cycle of HIV and SIV replication.: Virology. 2000 Aug 1;273(2):307-15. Unique Identifier : AIDSLINE MED/20377929; Roos JW; Maughan MF; Liao Z; Hildreth JE; Clements JE; Department of Comparative Medicine, Johns Hopkins University; School of Medicine, Baltimore, Maryland 21205, USA.; A single cycle of viral replication is the time required for a virus to enter the host cell, replicate its genome, and produce infectious progeny virions. The primate lentiviruses, human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV), require on average 24 h to complete one cycle of replication.
Human monoclonal antibody 98-6 reacts with the fusogenic form of gp41.: Virology. 2000 Aug 1;273(2):333-40. Unique Identifier : AIDSLINE MED/20377932; Taniguchi Y; Zolla-Pazner S; Xu Y; Zhang X; Takeda S; Hattori T; Laboratory of Virus Immunology, Kyoto University, Kyoto,; 606-8507, Japan.; A mixture of two peptides from gp41 (N36 and C34) forms an alpha-helical structure that is thought to represent the fusogenic form of gp41. A human anti-gp41 monoclonal antibody (mAb 98-6), generated from the cells of an infected individual, reacted poorly with C34, but binding was strongly enhanced when N36 was added
Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes.: Virology. 2000 Aug 1;273(2):374-82. Unique Identifier : AIDSLINE MED/20377936; Liu WJ; Liu XS; Zhao KN; Leggatt GR; Frazer IH; Center for Immunology and Cancer Research, Princess Alexandra; Hospital, Woolloogabba, Queensland, 4102, Australia.; Chimeric papillomavirus (PV) virus-like particles (VLPs) based on the bovine papillomavirus type 1 (BPV-1) L1 protein were constructed by replacing the 23-carboxyl-terminal amino acids of the BPV1 major protein L1 with an artificial polytope minigene, containing known CTL epitopes of human PV16 E7 protein, HIV IIIB
Results of viral marker screening of unpaid blood donations and probability of window period donations in 1997. EPFA Working Group on Quality Assurance.: Unique Identifier : AIDSLINE MED/20299304; Muller-Breitkreutz K; European Plasma Fractionation Association (EPFA), Amsterdam, The; Netherlands. T.Evers@epfa.nl; BACKGROUND AND OBJECTIVES: To monitor the safety of the blood supply and evaluate the potential benefits of additional measures, the likelihood of virus transmission must be assessed. The European Plasma Fractionation Association and its member organisations have therefore developed a surveillance system to monitor in
Mucosal immunization with experimental feline immunodeficiency virus (FIV) vaccines induces both antibody and T cell responses but does not protect against rectal FIV challenge.: Vaccine. 2000 Aug 1;18(28):3254-65. Unique Identifier : AIDSLINE MED/20330528; Finerty S; Stokes CR; Gruffydd-Jones TJ; Hillman TJ; Reeves NA; Whiting CV; Schaaper WM; Dalsgaard K; Harbour DA; Department of Clinical Veterinary Science, University of Bristol,; Langford, BS40 5DU, Bristol, UK. sue.finerty@bristol.ac.uk; Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which
Induction of protective immunity against pathogenic simian immunodeficiency virus by a foreign receptor-dependent replication of an engineered avirulent virus.: Vaccine. 2000 Aug 1;18(28):3310-8. Unique Identifier : AIDSLINE MED/20330534; Matano T; Kano M; Odawara T; Nakamura H; Takeda A; Mori K; Sato T; Nagai Y; AIDS Research Center, National Institute of Infectious Diseases,; 4-7-1 Gakuen, Musashi-murayama, 208-0011, Tokyo, Japan.; matano@nih.go.jp; In AIDS vaccine strategies, live attenuated vaccines can confer good resistance against pathogenic virus infections but have the potential risk of inducing disease, whereas safer replication-negative strategies such as DNA vaccinations have so far failed to prevent the disease onset. Here, we developed a novel DNA vac
Private industry, academia team up on HIV vaccine [news]: Am Fam Physician. 2000 Aug 1;62(3):483. Unique Identifier : AIDSLINE MED/20405140; Sweeney R; Lapp T
HHS updates and guidelines for antiretroviral therapy in HIV infection. Health and Human Services.: Am Fam Physician. 2000 Aug 1;62(3):661-2, 665. Unique Identifier : AIDSLINE MED/20405152; Morey SS
The HIV floor. On a student nursing rotation.: Am J Nurs. 2000 Aug;100(8):25. Unique Identifier : AIDSLINE MED/20406114; Davis M; Yale University School of Nursing, New Haven, CT, USA.
Effects of testosterone and progressive resistance training in eugonadal men with AIDS wasting. A randomized, controlled trial.: Ann Intern Med. 2000 Sep 5;133(5):348-55. Unique Identifier : AIDSLINE MED/20417627; Grinspoon S; Corcoran C; Parlman K; Costello M; Rosenthal D; Anderson E; Stanley T; Schoenfeld D; Burrows B; Hayden D; Basgoz N; Klibanski A; Massachusetts General Hospital, Harvard Medical School, Boston; University School of Medicine, and Boston Veterans Administration; Medical Center, 02114, USA.; BACKGROUND: Substantial loss of muscle mass occurs among men with AIDS wasting. OBJECTIVE: To investigate the independent effects of testosterone therapy and progressive resistance training in eugonadal men with AIDS wasting. DESIGN: Randomized, controlled trial. SETTING: University hospital. PATIENTS: 54 eugonadal me
Newborn screening for human immunodeficiency virus infection in the Bronx, NY, and evolving public health policy.: Am J Perinatol. 1999;16(10):503-7. Unique Identifier : AIDSLINE MED/20333168; McNeeley DF; Laroche L; Bhutra S; Suarez E; Rao S; Rajegowda B; Department of Pediatrics, Lincoln Medical and Mental Health; Center, The Bronx, New York, USA.; New advances in the diagnosis and treatment of HIV infection continue to propel changes in public understanding of HIV infection and the administration of public health law. Over the past decade, New York State has moved from a policy of blind newborn screening for seroprevalence data to mandatory HIV testing as part
MHC-based diagnostics and therapeutics - clinical applications for disease-linked genes.: Immunol Today. 1999 Apr;20(4):161-5. Unique Identifier : AIDSLINE MED/99221536; Howard MC; Spack EG; Choudhury K; Greten TF; Schneck JP; Corixa Corporation (formerly Anergen Inc.), Redwood City, CA,; USA.
Faces and phases of human CD8 T-cell development.: Immunol Today. 1999 Apr;20(4):177-80. Unique Identifier : AIDSLINE MED/99221540; Hamann D; Roos MT; van Lier RA; Dept of Clinical Viro Immunology CLB and Laboratory for; Experimental and Clinical Immunology, Academic Medical Centre; (AMC), Amsterdam, The Netherlands. D_Hamann@clb.nl
A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification.: Bone. 2000 Jul;27(1):69-74. Unique Identifier : AIDSLINE MED/20324963; Guicheux J; Palmer G; Shukunami C; Hiraki Y; Bonjour JP; Caverzasio J; Division of Bone Diseases, WHO Collaborating Center for; Osteoporosis, Department of Internal Medicine, University; Hospital of Geneva, Switzerland.; In vivo expression of the type III sodium-dependent phosphate transporter (NaPiT) Glvr-1 during endochondral ossification, suggests a functional role for inorganic phosphate (Pi) transport in cartilage calcification. For further analysis of this relationship, an in vitro model of endochondral ossification is required.
Liposomal amphotericin B as first line and secondary prophylactic treatment for visceral leishmaniasis in a patient infected with HIV.: Ann Ital Med Int. 2000 Apr-Jun;15(2):169-71. Unique Identifier : AIDSLINE MED/20375896; Borrelli P; Imperato A; Murdaca G; Scudeletti M; Dipartimento di Medicina Interna, Universita degli Studi di; Genova.; Visceral leishmaniasis has emerged in both endemic and non-endemic areas as an opportunistic infection in HIV-positive subjects. At risk for infection are HIV-positive intravenous drug abusers with a low CD4 T cell count and a high HIV viral load. In these patients, who are not always symptomatic, leishmaniasis is pro
A drug interaction between fusidic acid and a combination of ritonavir and saquinavir [letter]: Br J Clin Pharmacol. 2000 Jul;50(1):82-3. Unique Identifier : AIDSLINE MED/20344523; Khaliq Y; Gallicano K; Leger R; Foster B; Badley A
Detection of Epstein-Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas.: Br J Dermatol. 2000 Aug;143(2):320-3. Unique Identifier : AIDSLINE MED/20408664; Nagore E; Ledesma E; Collado C; Oliver V; Perez-Perez A; Aliaga A; Department of Dermatology, Hospital General Universitario,; C/Denia 20-6(a), 46006 Valencia, Spain. eduyame@meditex.es; BACKGROUND: Several studies have investigated the possible involvement of viral agents, particularly herpesviruses, in primary cutaneous lymphoma (PCL). OBJECTIVES: Our aim was to screen for the presence of human herpesvirus 7 (HHV-7) and 8 (HHV-8) genomes in samples of PCL, and to determine if their presence was inde
Increased circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ type 2 cytokine-producing cells, and decreased CLA+ type 1 cytokine-producing cells in atopic dermatitis.: Br J Dermatol. 2000 Aug;143(2):373-8. Unique Identifier : AIDSLINE MED/20408673; Teraki Y; Hotta T; Shiohara T; Department of Dermatology, Kyorin University School of Medicine,; 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.; teraki@kyorin-u.ac.jp; BACKGROUND: Skin-homing T cells are characterized by expression of cutaneous lymphocyte-associated antigen (CLA). Few data are available on the frequency of circulating CLA+ cytokine-producing T cells in atopic dermatitis (AD) patients. OBJECTIVES: We aimed to investigate cytokine synthesis capability vs. CLA expressi
Prevalence of CCR2-64I, SDF1-3'A and CCR5-Delta32 alleles in healthy Thais.: Eur J Immunogenet. 2000 Jun;27(3):153-7. Unique Identifier : AIDSLINE MED/20398546; Nookhai S; Ruxrungtham K; Phanuphak P; Oelrichs R; Thai Red Cross AIDS Research Centre, Pathumwan, Bangkok,; Thailand.; A genetic survey was performed of 200 healthy Thai blood donors for the frequency of three alleles that influence susceptibility to HIV infection and the rate of progression to HIV disease. The CCR5-Delta32 allele was not detected in this population. The CCR2-64I allele was detected at a frequency similar to that foun
Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer.: Hum Gene Ther. 2000 May 20;11(8):1139-50. Unique Identifier : AIDSLINE MED/20292468; Bosch A; Perret E; Desmaris N; Trono D; Heard JM; Unite de Retrovirus et Transfert Genetique, CNRS URA 1930,; Institut Pasteur, Paris, France.; Gene transfer vectors derived from human immunodeficiency virus (HIV-1) efficiently transduce nondividing cells and remain stably integrated in their genome. Long-term expression of reporter genes has been documented after intracerebral injection of these vectors. Using a HIV-based vector, we looked for a reversal of
Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire.: Hum Gene Ther. 2000 May 20;11(8):1151-64. Unique Identifier : AIDSLINE MED/20292469; Ferrand C; Robinet E; Contassot E; Certoux JM; Lim A; Herve P; Tiberghien P; Laboratoire de Therapeutique Immuno-Moleculaire, EFS; Bourgogne-Franche Comte, Besancon, France. tim@besancon.net; We have initiated a phase I/II clinical trial, involving the use of herpes simplex thymidine kinase gene (HS-tk)-expressing donor primary T cells, in order to modulate the graft-versus-host disease (GvHD) occurring after allogeneic hematopoietic stem cell transplantation. The preparation of gene-modified T cells (TkTC
Retrovirus-mediated gene transfer into T cells: 95% transduction efficiency without further in vitro selection.: Hum Gene Ther. 2000 May 20;11(8):1189-200. Unique Identifier : AIDSLINE MED/20292472; Movassagh M; Boyer O; Burland MC; Leclercq V; Klatzmann D; Lemoine FM; Biologie et Therapeutique des Pathologies Immunitaires, ESA CNRS; 7087 CERVI, CHU Pitie Salpetriere, Paris, France.; This study was designed to retrovirally transduce T cells by a protocol that would be simple, short, cost effective, applicable for clinical use, and efficient enough to avoid further selection of transduced T cells. Because retrovirally mediated infection is depending on the cell cycle, we first optimized the conditi
B-cell lymphoma-associated hemophagocytic syndrome: clinicopathological characteristics.: Ann Hematol. 2000 Jul;79(7):378-88. Unique Identifier : AIDSLINE MED/20418947; Miyahara M; Sano M; Shibata K; Matsuzaki M; Ibaraki K; Shimamoto Y; Tokunaga O; Department of Internal Medicine, Saga Medical School, Nabeshima,; Japan.; Seven patients with peripheral B-cell lymphoma associated with hemophagocytic syndrome are reported. In all cases, the histologic subtype was diffuse large B-cell lymphoma. Hemophagocytic features were noted in the bone marrow with lymphomatous infiltration. Hemophagocytic syndrome occurred with presentation of the ly
Factors associated with severe manifestations of histoplasmosis in AIDS.: Clin Infect Dis. 2000 Jun;30(6):877-81. Unique Identifier : AIDSLINE MED/20340588; Wheat LJ; Chetchotisakd P; Williams B; Connolly P; Shutt K; Hajjeh R; Department of Medicine, Indiana University School of Medicine,; Indianapolis, IN 46202, USA. lwheat@iupui.edu; We report factors associated with severe manifestations of histoplasmosis (such as shock, respiratory failure, and death) in patients with AIDS during an outbreak. Severe disease was present in 28 of 155 patients (17.9%). The following factors were associated with severe disease: black race (odds ratio [OR], 2.8; 95%
Immunorestitution disease involving the innate and adaptive response.: Clin Infect Dis. 2000 Jun;30(6):882-92. Unique Identifier : AIDSLINE MED/20340589; Cheng VC; Yuen K; Chan W; Wong SS; Ma ES; Chan RM; Department of Microbiology, Queen Mary Hospital, Hong Kong,; People's Republic of China.; Immunorestitution disease (IRD) is defined as an acute symptomatic or paradoxical deterioration of a (presumably) preexisting infection that is temporally related to the recovery of the immune system. We report the temporal sequence of events that led to IRD caused by Pneumocystis carinii and Aspergillus terreus in 2
Management of protease inhibitor-associated diarrhea.: Clin Infect Dis. 2000 Jun;30(6):908-14. Unique Identifier : AIDSLINE MED/20340592; Sherman DS; Fish DN; University of Colorado Health Sciences Center, Denver, CO 80262,; USA. doug.fish@uchsc.edu; Diarrhea is a common and often inadequately treated complication in patients with human immunodeficiency virus infection. Diarrhea has a significant impact on quality of life (QOL) and can contribute to malnutrition, weight loss, immunosuppression, and mortality. In addition, diarrhea may have a significant impact on
Tuberculous radiculomyelitis complicating tuberculous meningitis: case report and review.: Clin Infect Dis. 2000 Jun;30(6):915-21. Unique Identifier : AIDSLINE MED/20340593; Hernandez-Albujar S; Arribas JR; Royo A; Gonzalez-Garcia JJ; Pena JM; Vazquez JJ; Servicio de Medicina Interna (Unidad VIH), Hospital Universitario; "La Paz," Facultad de Medicina Universidad Autonoma de Madrid,; 28046 Madrid, Spain.; Tuberculous radiculomyelitis (TBRM) is a complication of tuberculous meningitis (TBM), which has been reported rarely in the modern medical literature. We describe a case of TBRM that developed in an human immunodeficiency virus (HIV)-infected patient, despite prompt antituberculous treatment. To our knowledge, this i
Prevalence and clinical significance of splenomegaly in asymptomatic human immunodeficiency virus type 1-infected adults. Swiss HIV cohort study.: Clin Infect Dis. 2000 Jun;30(6):943-5. Unique Identifier : AIDSLINE MED/20340601; Furrer H; Division of Infectious Diseases, University Hospital, CH-3010; Bern, Switzerland. hansjakob.furrer@insel.ch; In a prospective cohort study of 70 consecutive, asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected adults, splenomegaly was found by physical examination in 23% of patients and by ultrasound in 66%. Patients with concomitant liver disease had a higher prevalence of splenomegaly (RR 1.84; P
Possible malignant transformation of benign lymphoepithelial parotid lesions in human immunodeficiency virus-infected patients: report of three cases.: Clin Infect Dis. 2000 Jun;30(6):947-9. Unique Identifier : AIDSLINE MED/20340603; Del Bono V; Pretolesi F; Pontali E; Martinoli C; Bassetti M; Mazzarello G; Chiaramondia M; Derchi LE; Bassetti D; I Clinica Malattie Infettive, DISEM, Universita di Genova, 16132; Genova, Italy. bico001@pn.itnet.it; Benign lymphoepithelial parotid lesions (BLL) are intraparotid pathological changes that are commonly thought to be an early manifestation of human immunodeficiency virus (HIV) infection. It is not well known whether BLL may undergo malignant transformation into B cell lymphoma and may therefore be a sort of precancer
Peripherally inserted central catheters in patients with AIDS are associated with a low infection rate.: Clin Infect Dis. 2000 Jun;30(6):949-52. Unique Identifier : AIDSLINE MED/20340604; Skiest DJ; Abbott M; Keiser P; Division of Infectious Diseases, University of Texas Southwestern; Medical Center, Dallas, TX 75235-9133, USA.; dskies@mednet.swmed.edu; We reviewed the medical records of all human immunodeficiency virus (HIV)-infected patients who had a peripherally inserted central catheter (PICC) placed during a 1-year period. Ninety-seven PICCs were inserted in 66 patients for 8337 catheter-days. Eighty of 97 catheters were used primarily to treat
Entamoeba histolytica/Entamoeba dispar infections in human immunodeficiency virus-infected patients in the United States [see comments]: Clin Infect Dis. 2000 Jun;30(6):955-9. Unique Identifier : AIDSLINE MED/20340607; Lowther SA; Dworkin MS; Hanson DL; Division of HIV/AIDS Prevention-Surveillance and Epidemiology,; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA, USA.; We describe the incidence of and laboratory and clinical characteristics associated with Entamoeba histolytica/Entamoeba dispar infection diagnosed in human immunodeficiency virus (HIV)-infected persons enrolled in the Adult and Adolescent Spectrum of HIV Disease Project. From 1 January 1990 to 1 January 1998 (82, 518
Response: Entamoeba infections in human immunodeficiency virus-infected patients: not just a tropical problem [editorial; comment]: Clin Infect Dis. 2000 Jun;30(6):959-61. Unique Identifier : AIDSLINE MED/20340608; Reed SL
Neurological symptoms during primary human immunodeficiency virus (HIV) infection correlate with high levels of HIV RNA in cerebrospinal fluid.: Clin Infect Dis. 2000 Jun;30(6):962-5. Unique Identifier : AIDSLINE MED/20340610; Tambussi G; Gori A; Capiluppi B; Balotta C; Papagno L; Morandini B; Di Pietro M; Ciuffreda D; Saracco A; Lazzarin A; Division of Infectious Diseases, San Raffaele Scientific; Institute, 20127 Milano, Italy. giuseppe.tambussi@hsr.it; This analysis involves 22 patients with diagnosed symptomatic human immunodeficiency virus (HIV) infection. Neurologic symptoms were present in 11 patients, ranging from severe and persistent headache to clinical signs suggestive of meningitis. A strong correlation between neurological symptoms and cerebrospinal fluid
Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis.: Cytokine. 2000 Jul;12(7):1092-9. Unique Identifier : AIDSLINE MED/20340658; Chabaud M; Garnero P; Dayer JM; Guerne PA; Fossiez F; Miossec P; Department of Immunology and Rheumatology, Faculte de Medecine; Laennec, Hopital Edouard Herriot, Lyon, France.; Interleukin (IL-)17 is a T cell-derived pro-inflammatory cytokine produced by RA synovium. We studied the role of IL-17 in the synovium cytokine network to determine whether it can influence the inflammatory and destructive pattern characteristic of RA. Herein, we investigated whether the production and action of MMP-
Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.: Cytokine. 2000 Jul;12(7):1120-3. Unique Identifier : AIDSLINE MED/20340663; Kusuhara H; Yamaguchi S; Matsuyuki H; Sugahara K; Komatsu H; Terasawa M; Drug Discovery Laboratories, Welfide Corporation, Osaka, Japan.; kusuhara@welfide.co.jp; Interleukin (IL)-5 has been shown to play an essential role in the pathogenesis of airway inflammation. We investigated the effect of 4-(2-chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6, 9-dimethyl-6 H -thieno[3,2- f ][1,2,4]triazolo[4,3- a][1,4]diazepine (Y-24180), an antagonist of platelet-activating factor (PAF), on
Probing hydrogen bonds in the antibody-bound HIV-1 gp120 V3 loop by solid state NMR REDOR measurements.: Unique Identifier : AIDSLINE MED/20285159; Balbach JJ; Yang J; Weliky DP; Steinbach PJ; Tugarinov V; Anglister J; Tycko R; We describe solid state NMR measurements on frozen solutions of the complex of the 24-residue HIV-1 gp120 V3 loop peptide RP135 with the Fab fragment of the anti-gp120 antibody 0.5beta, using rotational echo double resonance (REDOR). In order to probe possible hydrogen bonding between arginine side chains and glycine
HTLV-1 is lower in blood donors in West Midlands than South Thames [letter]: BMJ. 2000 Aug 5;321(7257):380-1. Unique Identifier : AIDSLINE MED/20441353; Kurtz J; Smith N; Harbour S
Indian agency admits publishing "wrong" HIV figures [news]: BMJ. 2000 Aug 12;321(7258):402. Unique Identifier : AIDSLINE MED/20395941; Mudur G
Th1 and Th2 responses: what are they?: BMJ. 2000 Aug 12;321(7258):424. Unique Identifier : AIDSLINE MED/20395949; Berger A
Gambling problems in substance abusers are associated with increased sexual risk behaviors.: Addiction. 2000 Jul;95(7):1089-100. Unique Identifier : AIDSLINE MED/20418522; Petry NM; Department of Psychiatry, University of Connecticut School of; Medicine, Farmington 06030-1517, USA. petry@psychiatry.uchc.edu; OBJECTIVES: This study evaluated the association between gambling problems and HIV risk behaviors in substance abusers. PARTICIPANTS AND SETTING: One hundred and thirty-four substance abusers were recruited from advertisements placed in newspapers and at social service agencies. INTERVENTION: Gambling problems were as
HHV-8 is not a cofactor in the pathogenesis of environmentally induced malignant pleural mesothelioma.: Monaldi Arch Chest Dis. 2000 Apr;55(2):110-3. Unique Identifier : AIDSLINE MED/20406417; Olut AI; Ertugrul DT; Kocagoz T; Er M; Emri S; Dept of Clinical Microbiology, Hacettepe University, Ankara,; Turkey.; After the recognition of human herpes virus 8 (HHV-8) in Kaposi s sarcoma lesions, this new virus has been shown to be associated with various types of malignancy. One of them, body cavity-based lymphoma, is a high grade B-cell lymphoma arising from the body cavities. Similarly, mesothelioma is a tumour that originate
[AIDS in Africa, considered as a disease of civilization]: Arch Pediatr. 2000 Jun;7(6):687-8. Unique Identifier : AIDSLINE MED/20369191; Huber C
[The precaution principle and blood transfusion]: Transfus Clin Biol. 2000 Jun;7(3):220-7. Unique Identifier : AIDSLINE MED/20375780; Sicard D; Service de medecine interne, hopital Cochin, Paris, France.; Because of the HIV and HCV virus transmission by transfusion during the eighties, there has been a retrospective reflection about the non-application of the precautionary principle, which has appeared only recently in the medical world. Since it was difficult to identify the real cause of the above-cited transmission
Effect of antiretroviral therapy on the incidence of bacterial pneumonia in patients with advanced HIV infection.: Am J Respir Crit Care Med. 2000 Jul;162(1):64-7. Unique Identifier : AIDSLINE MED/20363947; Sullivan JH; Moore RD; Keruly JC; Chaisson RE; Johns Hopkins School of Medicine, Baltimore, Maryland 21287-0003,; USA.; To determine the relationship of combination antiretroviral therapy and bacterial pneumonia, we assessed incidence of and risk factors for bacterial pneumonia in 1,898 human immunodeficiency virus (HIV)-infected patients with CD4 cell counts
Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy.: Brain. 2000 Aug;123 ( Pt 8):1660-6. Unique Identifier : AIDSLINE MED/20368202; Murata K; Dalakas MC; Neuromuscular Diseases Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, MD 20892-1382, USA.; To examine whether the Schwann cells in patients with autoimmune neuropathies have the potential to behave as professional antigen-presenting cells, we investigated the expression of the co-stimulatory molecules BB-1, B7-1 (CD80) B7-2 (CD86) and their counter-receptors CD28 or CTLA-4 (CD152) at the protein and mRNA le
Need for an external proficiency testing program for cytokines, chemokines, and plasma markers of immune activation.: Clin Diagn Lab Immunol. 2000 Jul;7(4):540-8. Unique Identifier : AIDSLINE MED/20342538; Fahey JL; Aziz N; Spritzler J; Plaeger S; Nishanian P; Lathey JL; Seigel J; Landay AL; Kilarui R; Schmitz JL; White C; Wara DW; Akridge R; Cutili J; Douglas SD; Reuben J; Shearer WT; Nokta M; Polland R; Schooley R; Asthana D; Mizrachi Y; Waxdal M; University of California, Los Angeles, USA.; jlfahey@microimmun.medsch.ucla.edu; An external evaluation program for measuring the performance of laboratories testing for cytokines and immune activation markers in biological fluids was developed. Cytokines, chemokines, soluble cytokine receptors, and other soluble markers of immune activation (CSM) were measured in plasma from a healthy human immun
Cloning of the bovine immunodeficiency virus gag gene and development of a recombinant-protein-based enzyme-linked immunosorbent assay.: Clin Diagn Lab Immunol. 2000 Jul;7(4):557-62. Unique Identifier : AIDSLINE MED/20342541; Zheng L; Swanson M; Liao J; Wood C; Kapil S; Snider R; Loughin TA; Minocha HC; Department of Diagnostic Medicine/Pathobiology, College of; Veterinary Medicine, Manhattan, Kansas 66506, USA.; An enzyme-linked immunosorbent assay (ELISA) was established for the rapid detection of specific bovine immunodeficiency virus (BIV) antibodies in cattle, using recombinant Gag protein as an antigen. The gag coding region from BIV was cloned into an expression vector, pQE32, which expressed high levels of recombinant
Serodiagnostic potential of culture filtrate antigens of Mycobacterium tuberculosis.: Clin Diagn Lab Immunol. 2000 Jul;7(4):662-8. Unique Identifier : AIDSLINE MED/20342559; Samanich KM; Keen MA; Vissa VD; Harder JD; Spencer JS; Belisle JT; Zolla-Pazner S; Laal S; Department of Pathology, New York University Medical Center, New; York, New York 10016, USA.; Our studies of the humoral responses of tuberculosis (TB) patients have defined the repertoire of culture filtrate antigens of Mycobacterium tuberculosis that are recognized by antibodies from cavitary and noncavitary TB patients and demonstrated that the profile of antigens recognized changes with disease progression
Nonradioactive techniques for measurement of in vitro T-cell proliferation: alternatives to the [(3)H]thymidine incorporation assay.: Clin Diagn Lab Immunol. 2000 Jul;7(4):687-92. Unique Identifier : AIDSLINE MED/20342563; Messele T; Roos MT; Hamann D; Koot M; Fontanet AL; Miedema F; Schellekens PT; Rinke de Wit TF; Ethiopian-Netherlands AIDS Research Project at the Ethiopian; Health and Nutrition Research Institute, Addis Ababa, Ethiopia.; enarp@telecom.net.et; T-cell proliferation is an important in vitro parameter of in vivo immune function and has been used as a prognostic marker of human immunodeficiency virus type 1 (HIV-1) disease progression. The proliferative capacity of T cells in response to various stimuli is commonly determined by a radioactive assay based on inc
Diagnosis of human immunodeficiency virus type 1 infection with different subtypes using rapid tests.: Clin Diagn Lab Immunol. 2000 Jul;7(4):698-9. Unique Identifier : AIDSLINE MED/20342565; Phillips S; Granade TC; Pau CP; Candal D; Hu DJ; Parekh BS; HIV Immunology and Diagnostics Branch, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; We evaluated six rapid tests for their sensitivity and specificity in diagnosing human immunodeficiency virus type 1 (HIV-1) infection using 241 specimens (172 HIV-1 positive, 69 HIV-1 negative) representing different HIV-1 subtypes (A [n = 40], B [n = 47], C [n = 28], E [n = 42], and F [n = 7]). HIVCHEK, Multispot, R
Serological detection of infection with diverse human and simian immunodeficiency viruses using consensus env peptides.: Clin Diagn Lab Immunol. 2000 Jul;7(4):706-9. Unique Identifier : AIDSLINE MED/20342568; Masciotra S; Rudolph DL; van der Groen G; Yang C; Lal RB; HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and; TB Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; Cross-species transmission has been shown to play an important role in the emergence of human retroviruses. We developed a generic enzyme immunoassay using synthetic peptides from gp41 and C2V3 consensus sequences (human immunodeficiency virus [HIV] type 1 [HIV-1] groups M, O, and N and the homologous region of simian
Optimizing adherence to pharmaceutical care plans.: J Am Pharm Assoc (Wash). 2000 Jul-Aug;40(4):475-85. Unique Identifier : AIDSLINE MED/20387828; Nichols-English G; Poirier S; Department of Clinical and Administrative Sciences, University of; Georgia College of Pharmacy, USA. gnichols@mail.mcg.edu; Adherence to pharmacotherapy is essential to optimal therapeutic outcomes. The pivotal role of the pharmacist in optimizing adherence encompasses many actions: assessing the adherence problem, identifying predisposing factors, providing comprehensive counseling, and recommending specific adherence strategies targeted
[The trend in the spread of HIV infection among the children born to HIV-infected mothers in Donets'k Province]: Lik Sprava. 2000 Jan-Feb;(1):118-21. Unique Identifier : AIDSLINE MED/20337163; Sliusar' LI; Kolomiitseva GN; Soshenko II; Kushnarev MA; Seliverstova VG; Kutovaia OA; Kalimbet NV; Neshcheret EN; Recordable in Donets k Province since the end of 1995 is an epidemic rise in incidence rates of HIV infection, with 3 to 3.5-fold annual increase in the number of children born to HIV-infected mothers. In 96.5 percent of the above children antibodies to HIV are detected at the time of birth, as evidenced by laboratory
Immigration, HIV infection, and sexually transmitted diseases in Europe.: AIDS Patient Care STDS. 2000 May;14(5):233-7. Unique Identifier : AIDSLINE MED/20293719; Smacchia C; Di Perri G; Boschini A; Parolin A; Concia E; Outpatient Service for Drug Abuse Control (SERT) of Villafranca; di Verona, Italy.
HIV-associated psoriasis.: AIDS Patient Care STDS. 2000 May;14(5):239-46. Unique Identifier : AIDSLINE MED/20293720; Mallon E; Bunker CB; Department of Dermatology, Imperial College School of Medicine,; Chelsea & Westminster Hospital, London, U.K.; Psoriasis occurs with at least undiminished frequency in HIV-infected individuals. The behavior of psoriasis in HIV disease is of interest, in terms of pathogenesis and therapy because of the background of profound immunodysregulation. It is paradoxical that, while drugs that target T lymphocytes are effective in psor
Pneumocystis carinii pneumonia as the first presentation of HIV infection in patients older than fifty.: AIDS Patient Care STDS. 2000 May;14(5):247-9. Unique Identifier : AIDSLINE MED/20293721; Jedlovsky V; Fleischman JK; Mount Sinai Services, Queens Hospital Center, Jamaica, New York,; USA.; A significant increase in the number of elderly patients first diagnosed with HIV infection at the time of presentation with an AIDS-related opportunistic infection has recently been reported. This suggests a significant delay in the diagnosis of HIV infection. Few data are available describing such cases and their ou
Impact of new developments in antiretroviral treatment on AIDS prevention and care in resource-poor countries.: AIDS Patient Care STDS. 2000 May;14(5):251-7. Unique Identifier : AIDSLINE MED/20293722; Colebunders R; Verdonck K; Nachega J; Kothari P; Institute of Tropical Medicine, Antwerp, Belgium. bcoleb@itg.be; Combination antiretroviral treatment (ARV) including protease inhibitors , decreased the morbidity and mortality due to AIDS in the industrialized world. Many obstacles remain before ARVs can be introduced in resource-poor countries: high treatment costs, lack of lab
HIV healthcare provider-patient interaction: observations on the process of providing antiretroviral treatment.: AIDS Patient Care STDS. 2000 May;14(5):259-68. Unique Identifier : AIDSLINE MED/20293723; Erger J; Grusky O; Mann T; Marelich W; University of Wisconsin, Eau Claire, USA. ergersj@uwec.edu; The meeting during which healthcare providers and newly infected HIV+ patients discuss treatment options is a critical stage in patients care. We describe 10 interactions between healthcare providers and HIV+ patients at two clinics. Two observers coded each of the 10 interactions for the content of the topics discus
Hematological complications and quality of life in hospitalized AIDS patients.: AIDS Patient Care STDS. 2000 May;14(5):269-79. Unique Identifier : AIDSLINE MED/20293724; Cosby C; Holzemer WL; Henry SB; Portillo CJ; Department of Community Health Systems, School of Nursing,; University of California, San Francisco, USA.; The relationships among the biological and physiological indicators of cytopenias in AIDS and measures of quality of life are not well characterized. The purpose of this secondary analysis was to determine the relationships among anemia, neutropenia and thrombocytopenia and characteristics of the individual, physiolog
St. John's Wort and HAART [news]: AIDS Patient Care STDS. 2000 May;14(5):281. Unique Identifier : AIDSLINE MED/20293725
ABT-378/r helpful in failing patients [news]: AIDS Patient Care STDS. 2000 May;14(5):281-2. Unique Identifier : AIDSLINE MED/20293727
Pill burden key to doing well [news]: AIDS Patient Care STDS. 2000 May;14(5):281-2. Unique Identifier : AIDSLINE MED/20293726
Naltrexone for lipodystrophy [news]: AIDS Patient Care STDS. 2000 May;14(5):283. Unique Identifier : AIDSLINE MED/20293728
Tree bark yields antifungal [news]: AIDS Patient Care STDS. 2000 May;14(5):286. Unique Identifier : AIDSLINE MED/20293733
The immune compromised host in the twenty-first century: management of mucocutaneous infections.: Unique Identifier : AIDSLINE MED/20292456; Johnson RA; Department of Dermatology, Beth Israel-Deaconess Medical Center,; Harvard Medical School, Boston, MA 02215, USA.; Infectious diseases encountered in dermatology have changed tremendously during the past few decades with the emergence of the immunocompromised host. This change is a result of the human immunodeficiency virus epidemic, use of immunomodulating drugs, bone marrow transplantation, increasing prevalence of diabetes mell
Common and unusual cases seen by an inpatient dermatology consult service.: Semin Cutan Med Surg. 2000 Mar;19(1):62-8. Unique Identifier : AIDSLINE MED/20292457; Jones DA; Johnson RA; Dermatology Residency Training Program, Harvard Medical School,; Boston, MA, USA.; This article describes common consult requests and presents case studies from the dermatology consult service of an academic hospital.
An unbridgeable gap? Comparing the HIV/AIDS epidemics in Australia and sub-Saharan Africa.: Aust N Z J Public Health. 2000 Jun;24(3):276-80. Unique Identifier : AIDSLINE MED/20393110; Wilkinson D; Dore G; South Australian Centre for Rural and Remote Health, University; of Adelaide. david.wilkinson@unisa.edu.au; OBJECTIVE: To compare the HIV/AIDS epidemics in Australia and sub-Saharan Africa, to outline reasons for differences, and to consider implications for the Asia and Pacific region. METHODS: Comparison of key indicators of the epidemic in Australia, and Africa viewed largely throu
Prevalence and acceptability of public health initiatives in licensed premises.: Aust N Z J Public Health. 2000 Jun;24(3):320-2. Unique Identifier : AIDSLINE MED/20393118; Wiggers J; Considine R; Daly J; Hazell T; Hunter Centre for Health Advancement, New South Wales.; jwiggers@doh.health.nsw.gov.au; OBJECTIVES: To determine the prevalence and acceptability of public health initiatives in licensed premises. METHODS: Licensees/managers of all 333 licensed premises in the Hunter Region of NSW were interviewed to assess the practice of, and interest in undertaking public health initiatives relating to: responsible se
Dendritic cells containing apoptotic melanoma cells prime human CD8+ T cells for efficient tumor cell lysis.: Cancer Res. 2000 Aug 15;60(16):4446-52. Unique Identifier : AIDSLINE MED/20424192; Jenne L; Arrighi JF; Jonuleit H; Saurat JH; Hauser C; Department of Dermatology, University Hospital Geneva,; Switzerland.; Dendritic cells (DCs) phagocytose apoptotic influenza-infected monocytes and cross-present influenza antigen to CD8+ T cells, generating a specific CTL response. We investigated whether apoptotic melanoma cells, presented by this mechanism, can lead to CTL responses to tumor-associated antigens and melanoma cells. Apo
Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.: Cancer Res. 2000 Aug 15;60(16):4499-506. Unique Identifier : AIDSLINE MED/20424199; Valmori D; Dutoit V; Lienard D; Rimoldi D; Pittet MJ; Champagne P; Ellefsen K; Sahin U; Speiser D; Lejeune F; Cerottini JC; Romero P; Division of Clinical Onco-Immunology, Ludwig Institute for Cancer; Research, University Hospital, Lausanne, Switzerland.; Danila.Valmori@inst.hospvd.ch; Cancer testis (CT) antigens are particularly interesting candidates for cancer vaccines. However, T-cell reactivity to CT antigens has been detected only occasionally in cancer patients, even after vaccination. A new group of CT antigens has been recently identified using the SEREX technique based on immunoscreening o
Genetic selection for dissociative inhibitors of designated protein-protein interactions.: Nat Biotechnol. 2000 Aug;18(8):847-51. Unique Identifier : AIDSLINE MED/20392303; Park SH; Raines RT; Department of Biochemistry, University of Wisconsin-Madison,; 53706, USA.; Many biological processes rely on protein-protein interactions. These processes include signal transduction, cell cycle regulation, gene regulation, and viral assembly and replication. Moreover, many proteins and enzymes manifest their function as oligomers. We describe here an efficient means to sift through large co
Phage display of peptide epitopes from HIV-1 elicits strong cytolytic responses.: Nat Biotechnol. 2000 Aug;18(8):873-6. Unique Identifier : AIDSLINE MED/20392308; De Berardinis P; Sartorius R; Fanutti C; Perham RN; Del Pozzo G; Guardiola J; Institute of Protein Biochemistry Enzymology CNR, Naples, Italy.; deberard@ibpe.na.cnr.it; Although much effort has been expended on evaluating recombinant proteins and synthetic peptides as immunogens, they have generally proved incapable of inducing an efficient cytotoxic T-cell (CTL) response. Filamentous bacteriophage fd can display multiple copies of foreign peptides in the N-terminal region of its maj
An immunoablative regimen of fludarabine and cyclophosphamide prevents fully MHC-mismatched murine marrow graft rejection independent of GVHD.: Biol Blood Marrow Transplant. 2000;6(2A):182-9. Unique Identifier : AIDSLINE MED/20273473; Petrus MJ; Williams JF; Eckhaus MA; Gress RE; Fowler DH; Medical Oncology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; The prevention of graft rejection in the setting of nonmyeloablative transplant approaches might be mediated by chemotherapy-induced host immunoablation and by the graft-promoting effects of graft-versus-host disease (GVHD). To evaluate whether host immunoablation alone might allow for alloengraftment, we developed an
HIV resistance testing: value for money [editorial]: Hosp Med. 2000 May;61(5):304-5. Unique Identifier : AIDSLINE MED/20409894; Omrani AS; Pillay D
The molecular genetics of human herpesvirus 8.: Hosp Med. 2000 May;61(5):306-9. Unique Identifier : AIDSLINE MED/20409895; Gill J; Powles T; Bower M; Department of HIV Medicine, Westminster Hospital, London.; Epidemiological evidence from the early 1990s suggested that a sexually transmitted infectious agent other than the HIV virus was associated with the development of Kaposi s sarcoma in patients with HIV. A novel gamma herpesvirus was identified in Kaposi s sarcoma lesions. The molecular genetics of this virus are revi
HIV, childbirth and suicidal behaviour: a review.: Hosp Med. 2000 May;61(5):311-4. Unique Identifier : AIDSLINE MED/20409896; Green L; Ardron C; Catalan J; Lakeside Mental Health Unit, West Middlesex University Hospital,; Isleworth, Middlesex.; Women who are both pregnant and HIV positive may be at particularly high risk of suicidal behaviour. This is important in view of recent guidelines recommending routine antenatal HIV testing. We present a case and review the relevant literature.
Preventing perinatal transmission of HIV-1 infection.: Hosp Med. 2000 May;61(5):315-8. Unique Identifier : AIDSLINE MED/20409897; Fiore S; Newell ML; Department of Epidemiology and Public Health, University College; London.; It is now known that with the use of antiretroviral prophylaxis with zidovudine, elective caesarean section delivery and refraining from breastfeeding the rate of mother-child transmission of HIV infection can be reduced to less than 2%.
Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1.: Unique Identifier : AIDSLINE MED/20286709; Kazzaz J; Neidleman J; Singh M; Ott G; O'Hagan DT; Microparticles with entrapped antigens have recently been shown to possess significant potential as vaccine delivery systems and adjuvants. However, the potential of microparticles as adjuvants has been seriously limited by the common problem of degradation and denaturation of antigens following encapsulation and rele
Treatment with acetyl-L-carnitine has the potential to improve the clinical course of painful peripheral neuropathies in HIV-positives patients [letter; comment]: J Peripher Nerv Syst. 1998;3(3):227-9. Unique Identifier : AIDSLINE MED/20415156; Famularo G; De Simone C
Vitamin A status in relation to electroretinographic and electrooculographic findings in HIV infection.: Clin Neurophysiol. 2000 Jul;111(7):1234-40. Unique Identifier : AIDSLINE MED/20342750; Bartel P; Roux P; van Niekerk M; Department of Neurology, Pretoria Academic Hospital and; University of Pretoria, Pretoria, South Africa.; pbartel@medic.up.ac.za; OBJECTIVES: To investigate the electrooculogram (EOG) and an expanded battery of electroretinograms (ERGs) in HIV-infected subjects without retinopathy at two different levels of immunosuppression. Consideration was given to the possible effects of serum levels of vitamin A. METHODS: Two groups of neurologically norma
Botswana wants to make HIV reporting mandatory and push counseling to reduce AIDS chaos [news]: Circulation. 2000 Aug 29;102(9):E9016-7. Unique Identifier : AIDSLINE MED/20425898; SoRelle R
Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse.: Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):251-61. Unique Identifier : AIDSLINE MED/20394281; Thomas HE; Kay TW; The Walter and Eliza Hall Institute of Medical Research, PO Royal; Melbourne Hospital, Victoria 3050, Australia.; In the non-obese diabetic (NOD) mouse model of Type 1 (insulin-dependent) diabetes, evidence suggests that pancreatic beta cells are destroyed in part by apoptotic mechanisms. The precise mechanisms of beta cell destruction leading to diabetes remain unclear. The NOD mouse has been studied to gain insight into the cel
Soft tissues and osteo-articular infections in HIV-infected patients and other immunodeficient states.: Baillieres Best Pract Res Clin Rheumatol. 1999 Mar;13(1):115-28. Unique Identifier : AIDSLINE MED/20411596; Espinoza LR; Berman A; Section of Rheumatology, Louisiana State University School of; Medicine, New Orleans, USA.; Soft tissue and osteo-articular infections are rarely seen in patients with HIV infection and other immunodeficiency states. When present in HIV-infected patients, they tend to occur in the presence of low CD4(+)cell counts, intravascular indwelling catheters, extra-articular infection and trauma, and in intravenous d
Skeletal tuberculosis and other granulomatous infections.: Baillieres Best Pract Res Clin Rheumatol. 1999 Mar;13(1):163-77. Unique Identifier : AIDSLINE MED/20411599; Paradisi F; Corti G; Infectious Disease Unit, University of Florence School of; Medicine, Italy.; After several decades of steadily decreasing incidence, tuberculosis has had a resurgence in the past 15 years, not only in the lungs, but also in extrapulmonary sites. This is primarily a result of the AIDS pandemic, considering that HIV specifically affects cellular immunity, which is the first-line defence against
Septic arthritis.: Baillieres Best Pract Res Clin Rheumatol. 1999 Mar;13(1):37-58. Unique Identifier : AIDSLINE MED/20411592; Carreno Perez L; Universidad Complutense de Madrid, Spain.; Septic arthritis is a direct invasion of the joints by pathogenic micro-organisms. These micro-organisms and their products stimulate the release of pro-inflammatory cytokines and proteolytic enzymes that induce an inflammatory response and degradation of the cartilage. Staphylococcus aureus remains the most prevalent
[The AIDS emergency]: Assist Inferm Ric. 1999 Jul-Sep;18(3):165-70. Unique Identifier : AIDSLINE MED/20425756; Mukwaya J
gp120-induced alterations of human astrocyte function: Na(+)/H(+) exchange, K(+) conductance, and glutamate flux.: Am J Physiol Cell Physiol. 2000 Sep;279(3):C700-8. Unique Identifier : AIDSLINE MED/20402754; Patton HK; Zhou ZH; Bubien JK; Benveniste EN; Benos DJ; Department of Physiology & Biophysics, University of Alabama at; Birmingham, Birmingham, Alabama 35294, USA.; Many human immunodeficiency virus (HIV)-infected patients suffer from impaired neurological function and dementia . This facet of the disease has been termed acquired immunodeficiency syndrome (AIDS)-associated dementia complex (ADC). Several cell types, including astrocytes and neu
Haemophagocytic syndrome associated with infections.: Baillieres Best Pract Res Clin Haematol. 2000 Jun;13(2):163-78. Unique Identifier : AIDSLINE MED/20402816; Tiab M; Mechinaud F; Harousseau JL; Service de Medecine Interne Hematologie, Centre Hospitalier; Departemental, La Roche-sur-Yon, France.; Haemophagocytic syndromes (HS) are the clinical manifestation of an increased macrophagic activity with haemophagocytosis. Pathophysiology is related to a deregulation of T-lymphocytes and excessive production of cytokines. The main clinicobiological features are fever, hepatosplenomegaly, adenopathies, skin rash, neu
Haematological aspects of HIV infection.: Baillieres Best Pract Res Clin Haematol. 2000 Jun;13(2):215-30. Unique Identifier : AIDSLINE MED/20402819; Evans RH; Scadden DT; AIDS Research Center & Massachusetts General Hospital Cancer; Center, Harvard Medical School, 149 13th Street, Room 5212,; Boston, Massachusetts 02129, USA.; Multiple interacting factors contribute to the haematological manifestations of HIV disease. The effects of HIV-1 infection influence all haemopoietic cell lineages resulting in a spectrum of haematological abnormalities. Even in the absence of other pathological processes, bone marrow morphology is invariably abnorma
Human T-lymphotropic virus type 1 infection.: Baillieres Best Pract Res Clin Haematol. 2000 Jun;13(2):231-43. Unique Identifier : AIDSLINE MED/20402820; Tsukasaki K; Koeffler P; Tomonaga M; Department of Medicine, UCLA School of Medicine, CA, USA.; Human T-cell lymphotropic virus type-1 (HTLV-1) is aetiologically associated with adult T-cell leukaemia/lymphoma (ATL). HTLV-1 infection can also lead to various non-malignant diseases, for example, HTLV-1 associated myelopathy/tropical spastic paraparesis and HTLV-1 uveitis. HTLV-1 is endemic in southern
The Maryland Division of Correction Medical-Parole Program: a four-year experience, 1991 to 1994.: AIDS Public Policy J. 1996 Spring;11(1):21-7. Unique Identifier : AIDSLINE MED/20369668; Kendig NE; Boyle B; Swetz A; Division of Correction, Maryland Department of Public Safety and; Correctional Services, Baltimore, USA.
Developing vaccines against HIV: options for accelerated progress.: AIDS Public Policy J. 1996 Spring;11(1):28-35. Unique Identifier : AIDSLINE MED/20369669; Mahoney RT; International Vaccine Institute, Seoul, Korea.
Forum on prisoners' access to clinical trials: summary of recommendations.: AIDS Public Policy J. 1996 Spring;11(1):3-20. Unique Identifier : AIDSLINE MED/20369667; Stein GL; Headley LD; HIV Professional Development Project, New York Academy of; Medicine, N.Y., USA.
Rural HIV-service networks: patterns of care and policy issues.: AIDS Public Policy J. 1996 Spring;11(1):36-46. Unique Identifier : AIDSLINE MED/20369670; Berry DE; McKinney MM; McClain M; Department of Health Care Administration, University of Nevada,; Las Vegas, USA.
Medicaid policies for the physicians' services provided to Medicaid recipients with AIDS.: AIDS Public Policy J. 1996 Spring;11(1):47-60. Unique Identifier : AIDSLINE MED/20369671; Buchanan RJ; Colby D; Department of Community Health, University of Illinois,; Champaign, USA.
Required HIV antibody testing, social risk, and HIV-vaccine efficacy trials.: AIDS Public Policy J. 1996 Summer;11(2):104-12. Unique Identifier : AIDSLINE MED/20369676; MacQueen KM; Buchbinder SP; Douglas JM; Judson FN; McKirnan DJ; Bartholow BN; Division of HIV/AIDS Prevention, National Center for HIV, STD,; and TB Prevention, Centers for Disease Control and Prevention in; Atlanta, Georgia, USA.
A duty to care: sterile injection equipment and illicit-drug use.: AIDS Public Policy J. 1996 Summer;11(2):63-5. Unique Identifier : AIDSLINE MED/20369672; Novick A; Yale University, USA.
Staying negative--it's not automatic: a harm-reduction approach to substance use and sex.: AIDS Public Policy J. 1996 Summer;11(2):66-77. Unique Identifier : AIDSLINE MED/20369673; Elovich R; Gay Men's Health Crisis, Inc., New York, USA.
The role of policy in community pharmacies' response to injection-drug use: results of a nationwide Canadian survey.: AIDS Public Policy J. 1996 Summer;11(2):78-88. Unique Identifier : AIDSLINE MED/20369674; Myers T; Cockerill R; Millson M; Rankin J; Worthington C; HIV Social, Behavioural and Epidemiological Studies Unit,; University of Toronto, Ontario, Canada.; The response rate to this survey reflects the salience of the topic and the professional concern about and interest in issues presented by HIV. The HIV/AIDS epidemic has presented pharmacists with one of the greatest challenges to their professional training, ethics, and practice. It further expedites a current re-exa
Insurance reimbursement policies and AIDS home healthcare: public and private financing mechanisms.: AIDS Public Policy J. 1996 Summer;11(2):89-103. Unique Identifier : AIDSLINE MED/20369675; Hanley BE; Department of Education, Administration, and Health Policy,; University of Maryland School of Nursing, Baltimore, USA.
One small ethical issue arising in ethnographic research.: AIDS Public Policy J. 1996 Fall;11(3):115-7. Unique Identifier : AIDSLINE MED/20369677; Novick A; Yale University, New Haven, Conn., USA.
HIV consortia services funded by Title II of the Ryan White CARE Act: a survey of the states.: AIDS Public Policy J. 1996 Fall;11(3):118-43. Unique Identifier : AIDSLINE MED/20369678; Buchanan RJ; Department of Community Health, University of Illinois,; Champaign, USA.
Syringe-exchange programs in the United States: where are we now?: AIDS Public Policy J. 1996 Fall;11(3):144-7. Unique Identifier : AIDSLINE MED/20369679; Paone D; Des Jarlais D; Clark J; Shi Q; Beth Israel Medical Center, New York City, USA.
AIDS obituaries in the New York Times.: AIDS Public Policy J. 1996 Fall;11(3):148-52. Unique Identifier : AIDSLINE MED/20369680; Winick C; City University of New York Graduate School, New York, USA.
Model-based allocation of HIV-prevention resources.: AIDS Public Policy J. 1996 Fall;11(3):153-5. Unique Identifier : AIDSLINE MED/20369681; Pinkerton SD; Abramson PR; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee, USA.
On our failure to face the link between drug use and AIDS.: AIDS Public Policy J. 1996 Winter;11(4):159-63. Unique Identifier : AIDSLINE MED/20369682; Blansfield HN; It is necessary that society accept the medical, neurological basis of compulsive drug/alcohol use in order for it to get on with finding and using pragmatic approaches to treatment, rather than punishment, as the rational way to deal with these issues. The increased availability of oral methadone must be promoted, no
Rethinking HIV counseling and testing.: AIDS Public Policy J. 1996 Winter;11(4):164-8. Unique Identifier : AIDSLINE MED/20369683; Levi J
Structural impediments to operational syringe-exchange programs.: AIDS Public Policy J. 1996 Winter;11(4):169-84. Unique Identifier : AIDSLINE MED/20369684; Heimer R; Bluthenthal RN; Singer M; Khoshnood K; Department of Epidemiology and Public Health, Yale University of; Medicine, New Haven, Conn., USA.
Drug-assistance programs funded by Title II of the Ryan White CARE Act: a survey of the states.: AIDS Public Policy J. 1996 Winter;11(4):185-203. Unique Identifier : AIDSLINE MED/20369685; Buchanan RJ; Smith SR; Department of Community Health, University of Illinois,; Champaign, USA.
Factors predicting safe-sex talk and condom use in early sexual relationships.: Health Commun. 2000;12(2):195-218. Unique Identifier : AIDSLINE MED/20394826; Troth A; Peterson CC; School of Psychology, University of Queensland, Australia.; This study explored some of the antecedents and consequences of young adults beliefs about safe-sex communication in their early couple relationships. The sample consisted of 237 unmarried, heterosexual Australian university students, 16 to 19 years of age, approximately evenly divided between virgins and those with
The ability of the AIDS quilt to motivate information seeking, personal discussion, and preventative behavior as a health communication intervention.: Health Commun. 2000;12(3):301-16. Unique Identifier : AIDSLINE MED/20394831; Knaus CS; Pinkleton BE; Austin EW; College of Education, University of Washington, Pullman, USA.; A Solomon 4-group-design-style field experiment examined the ability of the NAMES Project Foundation s AIDS Memorial Quilt (AIDS Quilt) to motivate information seeking, personal discussion, and behavioral outcomes among those who viewed it. Results indicate that the AIDS Quilt intervention explained significant differ
Natural history of HIV-associated esophageal disease in the era of protease inhibitor therapy.: Dig Dis Sci. 2000 Jul;45(7):1301-7. Unique Identifier : AIDSLINE MED/20415880; Bini EJ; Micale PL; Weinshel EH; Division of Gastroenterology, VA New York Harbor Healthcare; System, Bellevue Hospital, and NYU School of Medicine, New York; 10010, USA.; The aim of this study was to determine the outcome of patients with HIV-associated esophageal disease refractory to empiric antifungal therapy, both before and after the introduction of protease inhibitors . We reviewed the medical records of 629 consecutive HIV-infe
Treatment of chronic hepatitis C with amantadine.: Unique Identifier : AIDSLINE MED/20415892 P
CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone.: Drug Metab Dispos. 2000 Aug;28(8):865-8. Unique Identifier : AIDSLINE MED/20361825; Winter HR; Wang Y; Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle,; Washington, USA.; Using selective cytochrome P450 (CYP) inhibitors and clinical concentrations (4 microM) of dapsone (DDS), we found a major contribution of CYP2C9 and little or no contribution (
CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection.: Eur J Immunol. 2000 Jul;30(7):1797-806. Unique Identifier : AIDSLINE MED/20395217; Nansen A; Marker O; Bartholdy C; Thomsen AR; Institute of Medical Microbiology and Immunology, University of; Copenhagen, Denmark.; Chemokines and their receptors play a critical role in the selective recruitment of various leukocyte subsets. In this study, we correlated the expression of multiple chemokine and CC chemokine receptor (CCR) genes during the course of intracerebral (i.c.) infection with lymphocytic choriomeningitis virus (LCMV) and v
Functionally distinct CD8+ memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression.: Eur J Immunol. 2000 Jul;30(7):1823-9. Unique Identifier : AIDSLINE MED/20395220; Tussey L; Speller S; Gallimore A; Vessey R; Virology Unit, GlaxoWellcome Research and Development, Stevenage,; GB. lynda_tussey@merck.com; Human memory T lymphocytes have recently been re-defined as central or effector memory cells (Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Nature 1999. 401: 708-712). Effector memory cells (T(em)) are targeted to the peripheral tissues and show rapid effector function in response to antigenic s
Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis.: Eur J Immunol. 2000 Jul;30(7):1841-50. Unique Identifier : AIDSLINE MED/20395222; Magone MT; Chan CC; Beck L; Whitcup SM; Raz E; National Eye Institute, National Institutes of Health, Bethesda; 20892-1857, USA.; Seasonal allergic conjunctivitis is one of the most common manifestations of allergic disease, affecting 15 % population in the United States annually. Short ragweed (RW) is a major cause of seasonal allergies. Immunostimulatory DNA sequences (ISS or CpG motifs) can inhibit an on-going
CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches.: Eur J Immunol. 2000 Jul;30(7):1861-71. Unique Identifier : AIDSLINE MED/20395224; Gardby E; Lycke NY; Department of Medical Microbiology and Immunology, University of; Goteborg, Sweden.; CD19 exhibits a critical role as a response regulator in B cells, influencing activation, differentiation and survival. Accordingly, CD19-deficient mice largely lack B-1 cells, and their conventional B-2 cells are poor responders to thymus-dependent antigen. Since both B-1 and B-2 cells may contribute to the total int
T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.: Eur J Immunol. 2000 Jul;30(7):1929-38. Unique Identifier : AIDSLINE MED/20395231; Senn KA; McCoy KD; Maloy KJ; Stark G; Frohli E; Rulicke T; Klemenz R; Department of Pathology, University Hospital Zurich,; Switzerland.; The IL-1 receptor-related protein T1 is expressed on the surface of Th2, but not Th1 cells. Studies with anti-T1 monoclonal antibodies have suggested that T1 is critical for development of normal Th2-type responses. To elucidate the role of T1 in vivo, we generated T1-deficient mice and a T1-transgenic strain which se
Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity.: Eur J Immunol. 2000 Jul;30(7):1939-47. Unique Identifier : AIDSLINE MED/20395232; Tighe H; Takabayashi K; Schwartz D; Marsden R; Beck L; Corbeil J; Richman DD; Eiden JJ Jr; Spiegelberg HL; Raz E; Department of Medicine, The Sam and Rose Stein Institute for; Research of Aging, University of California, San Diego, La Jolla; 92093-0663, USA. htighe@ucsd.edu; Immunostimulatory DNA sequences (ISS) are a potent Th1 adjuvant. We hypothesized that conjugation of ISS to protein antigens would strongly enhance their immunogenicity because both antigen and adjuvant (ISS) would be delivered to the same locale/antigen-presenting cell. To test this hypothesis, we conjugated a 22-mer
Extrathymic signals regulate the onset of T cell repertoire selection.: Eur J Immunol. 2000 Jul;30(7):1948-56. Unique Identifier : AIDSLINE MED/20395233; Fairchild PJ; Waldmann H; Sir William Dunn School of Pathology, University of Oxford, GB.; Paul.Fairchild@path.ox.ac.uk; The thymus is the principal site of T cell development, coordinating positive and negative selection of an immunocompetent repertoire. The ability of fetal thymi from C57BL/6 mice to support these selection events in culture is, however, critically dependent on the timing of their excision: whereas thymi from 16 day e
Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses.: Eur J Immunol. 2000 Jul;30(7):1977-87. Unique Identifier : AIDSLINE MED/20395236; Holland MJ; Harcus YM; Riches PL; Maizels RM; Institute of Cell, Animal and Population Biology, University of; Edinburgh, GB.; Infections with parasitic helminths such as Nippostronglyus brasiliensis induce dominant type 2 responses from antigen-specific T helper cells. The potency of the Th2 bias can also drive Th2 responses to bystander antigens introduced at the same time as infection. We now report that the Th2-promoting effect of infecti
In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells.: Eur J Immunol. 2000 Jul;30(7):1998-2006. Unique Identifier : AIDSLINE MED/20395238; Hoshino T; Yagita H; Ortaldo JR; Wiltrout RH; Young HA; Laboratory of Experimental Immunology, DBS, NCI-FCRDC, Frederick,; USA. hoshino@med.kurume-u.ac.jp; IL-18 is considered to be a strong cofactor for CD4+ T helper 1 (Th1) cell induction. We have recently reported that IL-18 can induce IL-13 production in both NK cells and T cells in synergy with IL-2 but not IL-12, suggesting IL-18 can induce Th1 and Th2 cytokines whe
Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice.: Eur J Immunol. 2000 Jul;30(7):2007-14. Unique Identifier : AIDSLINE MED/20395239; Hondowicz BD; Park AY; Elloso MM; Scott P; University of Pennsylvania, School of Veterinary Medicine,; Philadelphia 19104, USA.; BALB/c and anti-IL-12-treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB/c mice, C3H mice treated transiently with an anti-IL-12 monoclonal antibody switch from a Th2 to a Th1 response and resolve their lesions once treatment is terminated. We report here that the
Beta-chemokines inhibit activation-induced death of lymphocytes from HIV-infected individuals.: Eur J Immunol. 2000 Jul;30(7):2048-55. Unique Identifier : AIDSLINE MED/20395243; Pinto LA; Williams MS; Dolan MJ; Henkart PA; Shearer GM; Experimental Immunology Branch, National Instititutes of Health,; National Cancer Institute, Bethesda, USA.; The present study investigates the role of the HIV-suppressive beta-chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1 and RANTES in activation-induced cell death (AICD). A pool of these beta-chemokines reduced anti-CD3-induced apoptosis of T cell blasts from healthy blood donors in a dose-dependent manner
The antigen dose determines T helper subset development by regulation of CD40 ligand.: Eur J Immunol. 2000 Jul;30(7):2056-64. Unique Identifier : AIDSLINE MED/20395244; Ruedl C; Bachmann MF; Kopf M; Basel Institute for Immunology, Switzerland.; Although the amount of antigen and the strength of T cell stimulation have been suggested to regulate Th1 vs. Th2 polarization, it remains unclear how the antigen dose and the strength of signal is detected by the T cell and translated into differential cytokine production. Using co-cultures of dendritic cells (DC) an
The effect of TGF-beta1 on immune responses of naive versus memory CD4+ Th1/Th2 T cells.: Eur J Immunol. 2000 Jul;30(7):2101-11. Unique Identifier : AIDSLINE MED/20395249; Ludviksson BR; Seegers D; Resnick AS; Strober W; Mucosal Immunity Section, LCI, NIAID, NIH, Bethesda 20892-1890,; USA.; The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation
The changing HIV epidemic in Italian pregnant women.: Eur J Obstet Gynecol Reprod Biol. 2000 Aug;91(2):149-53. Unique Identifier : AIDSLINE MED/20329960; Fiore S; Semprini AE; Ravizza M; Bucceri A; Muggiasca ML; Guerra B; Spinillo A; Pardi G; Department of Obstetrics and Gynecology, Ospedale San Paolo,; Milan, Italy. S.Fiore@ich.ucl.ac.uk; OBJECTIVE: To describe changes in the characteristics of HIV-pregnant women in Italy and the impact of strategies for prevention of HIV vertical transmission. STUDY DESIGN: Since 1985, HIV-infected women and their children are followed in 23 European centres in the European Collabor
HIF-1 and human disease: one highly involved factor.: Genes Dev. 2000 Aug 15;14(16):1983-91. Unique Identifier : AIDSLINE MED/20407247; Semenza GL; Institute of Genetic Medicine, Departments of Pediatrics and; Medicine, The Johns Hopkins University School of Medicine,; Baltimore, Maryland 21287-3914 USA. gsemenza@jhmi.edu
Age-related expression of the cellular prion protein in human peripheral blood leukocytes.: Haematologica. 2000 Jun;85(6):580-7. Unique Identifier : AIDSLINE MED/20341360; Politopoulou G; Seebach JD; Schmugge M; Schwarz HP; Aguzzi A; Institute for Neuropathology, University Hospital of Zurich,; Zurich.; BACKGROUND AND OBJECTIVE: Creutzfeldt-Jakob disease typically affects older patients, yet victims of new-variant Creutzfeldt-Jakob disease (nvCJD) are unusually young. Because the cellular prion protein PrP(C) is required for disease development, we investigated age-dependent variability in cell surface PrP(C) express
Preclinical evaluation of two human anti-hepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees.: Hepatology. 2000 Sep;32(3):588-96. Unique Identifier : AIDSLINE MED/20417948; Eren R; Ilan E; Nussbaum O; Lubin I; Terkieltaub D; Arazi Y; Ben-Moshe O; Kitchinzky A; Berr S; Gopher J; Zauberman A; Galun E; Shouval D; Daudi N; Eid A; Jurim O; Magnius LO; Hammas B; Reisner Y; Dagan S; XTL Biopharmaceuticals Ltd., Kiryat Weizmann, Rehovot, Israel.; Two human monoclonal antibodies (mAbs) against hepatitis B surface antigen (HBsAg) generated in the Trimera mouse system are described. Both mAbs 17.1.41 and 19.79.5 are of the IgG1 isotype and have high affinity constants for HBsAg binding in the range of 10(-10) mol/L. Monoclonal antibody 17.1.41 recognizes a confor
Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B [see comments]: Hepatology. 2000 Sep;32(3):604-9. Unique Identifier : AIDSLINE MED/20417950; Liaw YF; Tsai SL; Chien RN; Yeh CT; Chu CM; Liver Research Unit Chang Gung Memorial Hospital and Chang Gung; University, Taipei, Taiwan. liveryfl@tp.silkera.net; Asian lamivudine trial has shown that hepatitis B e antigen (HBeAg) seroconversion rate during 1 year of lamivudine therapy was only 16% but was 64% in the subgroup of patients with a pretherapy serum alanine transaminase (ALT) level over 5 times the upper limit of normal (ULN). To test whether ALT rebound following c
Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy.: Hepatology. 2000 Sep;32(3):635-9. Unique Identifier : AIDSLINE MED/20417955; Honkoop P; de Man RA; Niesters HG; Zondervan PE; Schalm SW; Department of Hepatogastroenterology, Erasmus University; Hospital, Rotterdam, The Netherlands.; Acute exacerbations of chronic hepatitis B virus (HBV) infection occur after withdrawal of lamivudine therapy in approximately 16% of patients and are considered of little clinical significance. We observed lamivudine withdrawal hepatitis accompanied by jaundice and incipient liver failure, but also followed by comp
Short-term corticosteroid therapy in combination with lamivudine: A case of deja vu? [comment] [editorial]: Hepatology. 2000 Sep;32(3):663-5. Unique Identifier : AIDSLINE MED/20417960; Perrillo RP
Combined interferon and lamivudine therapy: is this the treatment of choice for patients with chronic hepatitis B virus infection?: Hepatology. 2000 Sep;32(3):675-7. Unique Identifier : AIDSLINE MED/20426869; Terrault NA; Division of Gastroenterology/Liver Transplant Program, University; of California, San Francisco, USA.
Prevalence of CCR5 and CCR2 HIV-coreceptor gene polymorphisms in Belgium.: Hum Hered. 2000 Sep-Oct;50(5):304-7. Unique Identifier : AIDSLINE MED/20341396; Struyf F; Thoelen I; Charlier N; Keyaerts E; Van der Donck I; Wuu J; Van Ranst M; Laboratory of Virology, Department of Microbiology and; Immunology, Rega Institute for Medical Research, Leuven, Belgium.; frank.struyf@uz.kuleuven.ac.be; Polymorphisms of the chemokine receptor genes CCR5 and CCR2 are associated with resistance to HIV-1 infection or delayed progression to AIDS. Few data are available on their combined prevalence in healthy subjects; we therefore examined the occurrence of CCR5-Delta32 and CCR2-64I polymorphisms in a sample of 310 healt
gammadelta T-cell anergy in human immunodeficiency virus-infected persons with opportunistic infections and recovery after highly active antiretroviral therapy.: Unique Identifier : AIDSLINE MED/20387291; Martini F; Urso R; Gioia C; De Felici A; Narciso P; Amendola A; Paglia MG; Colizzi V; Poccia F; gammadelta T lymphocytes recognize non-peptidic microbial antigens without antigen processing and major histocompatibility complex (MHC) restriction, representing an early defence mechanism against invading pathogens. As a defective response to non-peptidic antigens was observed in human immunodeficiency virus-positiv
Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus.: Immunology. 2000 Aug;100(4):487-93. Unique Identifier : AIDSLINE MED/20387292; Han SN; Wu D; Ha WK; Beharka A; Smith DE; Bender BS; Meydani SN; Jean Mayer Human Nutrition Research Center on Aging at Tufts; University, Boston, MA, USA.; Compared with young mice, old mice infected with influenza virus have significantly higher pulmonary viral titres, although these can be reduced significantly with dietary vitamin E supplementation. T helper 1 (Th1) cytokines, especially interferon-gamma (IFN-gamma), play an important role in defending against influen
Increased resistance to mycobacterial infection in the absence of interleukin-10.: Immunology. 2000 Aug;100(4):494-501. Unique Identifier : AIDSLINE MED/20387293; Jacobs M; Brown N; Allie N; Gulert R; Ryffel B; Department of Immunology, University of Cape Town, South Africa.; Interleukin-10 (IL-10) down-regulates T helper type 1 cell and macrophage functions. As IL-10 is induced along with tumour necrosis factor (TNF) and IL-12 in mycobacterial infection, we asked whether endogenous IL-10 plays a role in the antimycobacterial response. We demonstrate here that IL-10-deficient mice eliminat
Association of the interleukin-4 receptor alpha variant Q576R with Th1/Th2 imbalance in connective tissue disease.: Immunogenetics. 2000 Jul;51(8-9):743-6. Unique Identifier : AIDSLINE MED/20395294; Youn J; Hwang SH; Cho CS; Min JK; Kim WU; Park SH; Kim HY; Department of Anatomy, College of Medicine, Hanyang University,; Seoul, Korea.
HIV-1 subtypes in injecting drug users & their non-injecting wives in Manipur, India.: Indian J Med Res. 2000 Jun;111:189-94. Unique Identifier : AIDSLINE MED/20425578; Chakrabarti S; Panda S; Chatterjee A; Sarkar S; Manna B; Singh NB; Naik TN; Detels R; Bhattacharya SK; National Institute of Cholera & Enteric Diseases (ICMR),; Calcutta.; The presence of HIV-1 antibodies was determined among the injecting drug users (IDUs) and their non-injecting wives. A total of 233 (72%) were found to be HIV-1 seropositive among the 322 subjects recruited in this study between August, 1996 and September, 1997. The distribution of HIV-1 subtypes among the injecting d
Preliminary observations on lymphocyte subpopulations in HIV seropositive & HIV seronegative tuberculosis patients in Pune, India.: Indian J Med Res. 2000 Jun;111:195-8. Unique Identifier : AIDSLINE MED/20425579; Tripathy S; Menon P; Joshi DR; Patil U; Gadkari DA; Paranjape RS; National AIDS Research Institute (ICMR), Pune.; CD4 and CD8 lymphocyte counts were determined in 59 HIV seropositive and 41 HIV seronegative newly diagnosed tuberculosis patients in Pune. There were significant differences in the CD4 counts and CD4/CD8 ratios between HIV seropositive and HIV seronegative tuberculosis patients. Majority of the HIV seropositive patie
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.: Infect Immun. 2000 Sep;68(9):5126-31. Unique Identifier : AIDSLINE MED/20407324; Mencacci A; Bacci A; Cenci E; Montagnoli C; Fiorucci S; Casagrande A; Flavell RA; Bistoni F; Romani L; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, 06122 Perugia,; Italy.; Caspase 1, formerly designated interleukin 1beta (IL-1beta)-converting enzyme, processes pro-IL-1beta and pro-IL-18 to yield active cytokines that play a pivotal role in inflammation and cell activation. We show here the effect of caspase 1 deficiency on the inflammatory and adaptive immune responses to the fungus Can
Analysis of the cellular infiltrate in the iris during experimental autoimmune encephalomyelitis.: Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3001-10. Unique Identifier : AIDSLINE MED/20424955; de Vos AF; Dick AD; Klooster J; Broersma L; McMenamin PG; Kijlstra A; Department of Ophthalmology-Immunolog, Netherlands Ophthalmic; Research Institute, Amsterdam. devos@immu.fgg.eur.nl; PURPOSE: Previous studies have shown that experimental autoimmune encephalomyelitis (EAE) and anterior uveitis (AU) develop in Lewis rats immunized with myelin basic protein (MBP). The purpose of this study was to characterize the dynamics, distribution, and phenotype of infiltrating cells in the iris during EAE-assoc
The role of apoptosis within the retina of coronavirus-infected mice.: Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3011-8. Unique Identifier : AIDSLINE MED/20424956; Wang Y; Detrick B; Yu ZX; Zhang J; Chesky L; Hooks JJ; Immunology and Virology Section, Laboratory of Immunology,; National Eye Institute, National Institutes of Health, Bethesda,; Maryland 20892, USA.; PURPOSE: To evaluate the possible roles of apoptosis in the murine retinopathy induced by coronavirus. METHODS: Mice were inoculated with virus intravitreally. Mouse eyes harvested at varying times after inoculation were evaluated for apoptotic and immunologic events by hematoxylin and eosin staining, immunohistochemi
Th1- and Th2-type lymphokine-assisted induction and release of chemokine receptors from primary human trophoblast cells.: Unique Identifier : AIDSLINE MED/20341383; Athanassakis I; Papadimitriou L; Koumantakis E; Vassiliadis S; Chemokine receptors (CCRs) have been demonstrated to facilitate the entry of HIV in different cell types of infected individuals, including CD4(+) T cells and dendritic cells. The natural or inducible expression of CCRs on trophoblast cells could provide a valid mechanism for the in utero transmission of HIV from moth
Mechanism of kappa B DNA binding by Rel/NF-kappa B dimers.: J Biol Chem. 2000 Aug 11;275(32):24392-9. Unique Identifier : AIDSLINE MED/20387323; Phelps CB; Sengchanthalangsy LL; Malek S; Ghosh G; Department of Chemistry and Biochemistry, University of; California San Diego, La Jolla, California 92093, USA.; The DNA binding of three different NF-kappaB dimers, the p50 and p65 homodimers and the p50/p65 heterodimer, has been examined using a combination of gel mobility shift and fluorescence anisotropy assays. The NF-kappaB p50/p65 heterodimer is shown here to bind the kappaB DNA target site of the immunoglobulin kappa enh
Mechanisms preventing allergen-induced airways hyperreactivity: role of tolerance and immune deviation.: J Allergy Clin Immunol. 2000 Aug;106(2):239-46. Unique Identifier : AIDSLINE MED/20391900; Tsitoura DC; Blumenthal RL; Berry G; Dekruyff RH; Umetsu DT; Department of Pediatrics, Divisions of Allergy and Clinical; Immunology, Immunology and Transplantation Biology, Stanford; University Medical Center, Stanford, CA 94305-5208, USA.; BACKGROUND: Aeroallergens continuously enter the respiratory tract of atopic individuals and provoke the development of asthma characterized by airway hyperreactivity (AHR) and inflammation. By contrast, nonatopic individuals are exposed to the same aeroallergens, but airway inflammation does not develop. However, the
Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils.: J Allergy Clin Immunol. 2000 Aug;106(2):307-12. Unique Identifier : AIDSLINE MED/20391910; Benson M; Stranneg~ard IL; Stranneg~ard O; Wennergren G; Department of Pediatrics and Clinical Virology, Sahlgrenska; University Hospital, Goteborg.; BACKGROUND: Topical treatment with glucocorticoids (GCs) is known to decrease eosinophils but not neutrophils in patients with allergic rhinitis. OBJECTIVE: We sought to examine whether the differential effects of GC treatment on eosinophils and neutrophils are mirrored by differential effects on T(H)1/T(H)2 cytokines
DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice.: J Allergy Clin Immunol. 2000 Aug;106(2):349-56. Unique Identifier : AIDSLINE MED/20391915; Horner AA; Nguyen MD; Ronaghy A; Cinman N; Verbeek S; Raz E; Department of Medicine and The Sam and Rose Stein Institute for; Research on Aging, University of California, San Diego, La Jolla,; USA.; BACKGROUND: Anaphylactic hypersensitivity is the most serious clinical concern facing allergists. However, for the majority of anaphylactic hypersensitivities, avoidance is the only therapeutic option presently available. OBJECTIVE: This study evaluated the effectiveness of primary gene and protein-immunostimulatory D
Bacterial vaginosis: a public health problem for women.: J Am Med Womens Assoc. 2000 Summer;55(4):220-4. Unique Identifier : AIDSLINE MED/20391041; Rauh VA; Culhane JF; Hogan VK; Heilbrunn Center for Population and Family Health, Joseph L.; Mailman School of Public Health, Columbia University, USA.; Bacterial vaginosis (BV) remains a moderately prevalent condition with clearly observed links to adverse reproductive, gynecological, and other outcomes in women, including human immunodeficiency virus infection. Because of inconsistent findings from clinical studies concerning BV s etiologic role, no definitive polic
Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice.: J Appl Toxicol. 2000 Jul-Aug;20(4):319-25. Unique Identifier : AIDSLINE MED/20402420; D'Cruz OJ; Waurzyniak B; Yiv SH; Uckun FM; Drug Discovery Program, Parker Hughes Institute, St. Paul, MN; 55113, USA. odcruz@ih.org; Heterosexual transmission of human immunodeficiency virus (HIV) accounts for 90% of all new infections worldwide and significantly contributes to new acquired immunodeficiency syndrome (AIDS) cases in the USA. In a systematic effort to develop a microbicidal contraceptive capable of preventing HIV transmission as well
Cutting edge: naive T cells masquerading as memory cells.: J Immunol. 2000 Aug 15;165(4):1733-7. Unique Identifier : AIDSLINE MED/20384759; Murali-Krishna K; Ahmed R; Emory Vaccine Center and Department of Microbiology and; Immunology, Emory University School of Medicine, Atlanta, GA; 30322, USA.; This study shows that naive CD8 T cells can acquire characteristics of memory T cells in the absence of stimulation with specific Ag simply by the process of homeostatic proliferation under lymphopenic conditions. This Ag-independent T cell differentiation pathway did not result in up-regulation of early activation ma
Infection of CD4+ memory T cells by HIV-1 requires expression of phosphodiesterase 4.: J Immunol. 2000 Aug 15;165(4):1755-61. Unique Identifier : AIDSLINE MED/20384762; Sun Y; Li L; Lau F; Beavo JA; Clark EA; Regional Primate Research Center, Department of Pharmacology and; Molecular, University of Washington, Seattle, WA 98195, USA.; Using PCR to monitor HIV-1 RNA genome reverse transcription and nuclear import of preintegration complexes, we found that memory, but not naive, CD4+ T cells could support transport of HIV-1 DNA to nuclei upon TCR/CD3 and IL-2 stimulation. Moreover, memory CD4+ T cells
Transgenic expression of Ly49A on T cells impairs a specific antitumor response.: J Immunol. 2000 Aug 15;165(4):1871-6. Unique Identifier : AIDSLINE MED/20384776; Brawand P; Lemonnier FA; MacDonald HR; Cerottini JC; Held W; Ludwig Institute for Cancer Research, Lausanne Branch, University; of Lausanne, Epalinges, Switzerland.; Inhibitory MHC receptors determine the reactivity and specificity of NK cells. These receptors can also regulate T cells by modulating TCR-induced effector functions such as cytotoxicity, cytokine production, and proliferation. Here we have assessed the capacity of mouse T cells expressing the inhibitory MHC class I r
IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells.: J Immunol. 2000 Aug 15;165(4):1877-81. Unique Identifier : AIDSLINE MED/20384777; Kalinski P; Smits HH; Schuitemaker JH; Vieira PL; van Eijk M; de Jong EC; Wierenga EA; Kapsenberg ML; Department of Cell Biology and Histology and Department of; Dermatology, Academic Medical Center, University of Amsterdam,; Amsterdam, The Netherlands. KalinskiP@msx.upmc.edu; IL-12 is a key inducer of Th1-associated inflammatory responses, protective against intracellular infections and cancer, but also involved in autoimmune tissue destruction. We report that human Th2 cells interacting with monocyte-derived dendritic cells (DC) effectively induce bioactive IL-12p70 and revert to Th0/Th1
Alpha beta TCR+ cells are a minimal fraction of peripheral CD8+ pool in MHC class I-deficient mice.: J Immunol. 2000 Aug 15;165(4):1896-901. Unique Identifier : AIDSLINE MED/20384780; Nesic D; Santori FR; Vukmanovic S; Michael Heidelberger Division of Immunology, Department of; Pathology and Kaplan Comprehensive Cancer Center, New York; University School of Medicine, New York, NY 10016, USA.; MHC class I molecules play a role in the maintenance of the naive peripheral CD8+ T cell pool. The mechanisms of the peripheral maintenance and the life span of residual CD8+ cells present in the periphery of beta 2-microglobulin-deficient (beta 2m-/-) mice are unknown. We here show that very few CD8+ cells in beta 2m
CD81 and CD28 costimulate T cells through distinct pathways.: J Immunol. 2000 Aug 15;165(4):1902-9. Unique Identifier : AIDSLINE MED/20384781; Witherden DA; Boismenu R; Havran WL; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.; We have examined the role of CD81 in the activation of murine splenic alphabeta T cells. Expression of the CD81 molecule on T cells increases following activation, raising the possibility of a role for this molecule in progression of the activation process. Using an in vitro costimulation assay, we show that CD81 can
Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.: Unique Identifier : AIDSLINE MED/20384782; Baars PA; Ribeiro Do Couto LM; Leusen JH; Hooibrink B; Kuijpers TW; Lens SM; van Lier RA; Circulating CD8+ T cells with a CD45RA+CD27- phenotype resemble cytolytic effector cells because they express various cytolytic mediators and are able to execute cytotoxicity without prior stimulation in vitro. We here demonstrate that CD8+CD45RA+CD27- T cells can use both granule exocytosis and Fas/Fas ligand pathway
Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression.: J Immunol. 2000 Aug 15;165(4):2028-39. Unique Identifier : AIDSLINE MED/20384796; Weiden M; Tanaka N; Qiao Y; Zhao BY; Honda Y; Nakata K; Canova A; Levy DE; Rom WN; Pine R; Division of Pulmonary and Critical Care Medicine and Bellevue; Chest Service, Department of Pathology, New York University; Medical Center, New York, NY 10016, USA.; HIV-1 replication is inhibited in uninflamed lung macrophages and is stimulated during tuberculosis. Attempts to recapitulate activation of HIV-1 replication in primary monocytes and macrophages ex vivo and in the untreated and PMA-treated THP-1 cell line model in vitro have produced opposite results depending on the
Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.: J Immunol. 2000 Aug 15;165(4):2077-83. Unique Identifier : AIDSLINE MED/20384802; Brander C; Suscovich T; Lee Y; Nguyen PT; O'Connor P; Seebach J; Jones NG; van Gorder M; Walker BD; Scadden DT; Partners AIDS Research Center and Massachusetts General Hospital; Cancer Center, Massachusetts General Hospital and Harvard Medical; School, Boston, MA 02129, USA.; Kaposi s sarcoma-associated herpes virus (KSHV) is a recently identified human gamma2-herpesvirus associated with Kaposi s sarcoma, primary effusion lymphoma, and Castleman s disease. We reasoned that CTL responses may provide host defense against this virus, and consequently, KSHV may have evolved strategies to evade
Recombinant attenuated Toxoplasma gondii expressing the Plasmodium yoelii circumsporozoite protein provides highly effective priming for CD8+ T cell-dependent protective immunity against malaria.: Unique Identifier : AIDSLINE MED/20384803; Charest H; Sedegah M; Yap GS; Gazzinelli RT; Caspar P; Hoffman SL; Sher A; The protozoan parasite Toxoplasma gondii elicits strong cell-mediated immunity against itself as well as nonspecific resistance against other pathogens and tumors. For this reason, we asked whether recombinant Toxoplasma could be utilized as an effective vaccine vehicle for inducing immunity against heterologous micro
Expression of intracellular IFN-gamma in HSV-1-specific CD8+ T cells identifies distinct responding subpopulations during the primary response to infection.: J Immunol. 2000 Aug 15;165(4):2101-7. Unique Identifier : AIDSLINE MED/20384805; Andersen H; Dempsey D; Chervenak R; Jennings SR; Department of Microbiology and Immunology, Louisiana State; University Health Sciences Center School of Medicine, Shreveport,; LA 71130, USA.; Cutaneous infection in the footpads of C57BL/6 mice with HSV-1 results in an accumulation of activated (CD44high CD25+) CD8+ T cells within the draining popliteal lymph node (PLN). These studies were undertaken to evaluate the frequency and phenotype of the CD8+ T cell population within the PLN, recognizing the single
Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells.: J Immunol. 2000 Aug 15;165(4):2205-13. Unique Identifier : AIDSLINE MED/20384818; Sekiya T; Miyamasu M; Imanishi M; Yamada H; Nakajima T; Yamaguchi M; Fujisawa T; Pawankar R; Sano Y; Ohta K; Ishii A; Morita Y; Yamamoto K; Matsushima K; Yoshie O; Hirai K; Departments of Allergy and Rheumatology, University of Tokyo; Graduate School of Medicine, Tokyo, Japan.; CCR4 is now known to be selectively expressed in Th2 cells. Since the bronchial epithelium is recognized as an important source of mediators fundamental to the manifestation of respiratory allergic inflammation, we studied the expression of two functional ligands for CCR4, i.e., macrophage-derived chemokine (MDC) and
Proinflammatory and Th2-derived cytokines modulate CD40-mediated expression of inflammatory mediators in airway epithelia: implications for the role of epithelial CD40 in airway inflammation.: J Immunol. 2000 Aug 15;165(4):2214-21. Unique Identifier : AIDSLINE MED/20384819; Propst SM; Denson R; Rothstein E; Estell K; Schwiebert LM; Department of Physiology and Biophysics, University of Alabama,; Birmingham, AL 35294, USA.; Cytokines produced by activated macrophages and Th2 cells within the lung play a key role in asthma-associated airway inflammation. Additionally, recent studies suggest that the molecule CD40 modulates lung immune responses. Because airway epithelial cells can act as immune effector cells through the expression of inf
IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production.: J Immunol. 2000 Aug 15;165(4):2222-31. Unique Identifier : AIDSLINE MED/20384820; Wang J; Homer RJ; Hong L; Cohn L; Lee CG; Jung S; Elias JA; Section of Pulmonary and Critical Care Medicine, Department of; Internal Medicine, Yale University School of Medicine, New Haven,; CT 06520, USA.; IL-11 is a pleiotropic cytokine that induces tissue remodeling with subepithelial fibrosis when expressed in the airway. Its effects on the Th2-dominated airway inflammation that is characteristic of asthma, however, are poorly understood. To characterize the effects of IL-11 on Th2 tissue inflammation, we compared th
CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination.: J Immunol. 2000 Aug 15;165(4):2278-86. Unique Identifier : AIDSLINE MED/20384827; Wu GF; Dandekar AA; Pewe L; Perlman S; Program in Neuroscience, Departments of Pediatrics and; Microbiology, and University of Iowa College of Medicine,; University of Iowa, Iowa City, IA 52242, USA.; A chronic demyelinating disease results from murine infection with the neurotropic strain JHM of mouse hepatitis virus (MHV-JHM). Demyelination is largely immune mediated. In this study, the individual roles of CD4 and CD8 T cells in MHV-induced demyelination were investigated using recombination-activating gene 1-/-
Status of activation of circulating vaccine-elicited CD8+ T cells.: J Immunol. 2000 Aug 15;165(4):2287-96. Unique Identifier : AIDSLINE MED/20384828; Nielsen MB; Monsurro V; Migueles SA; Wang E; Perez-Diez A; Lee KH; Kammula U; Rosenberg SA; Marincola FM; Surgery Branch, Division of Clinical Sciences, National Cancer; Institute, Bethesda, MD 20892-1502, USA.; Selective blunting of the status of activation of circulating tumor-specific T cells was invoked to explain their paradoxical coexistence with unhampered tumor growth. By analogy, lack of tumor regression in the face of observable melanoma vaccine-induced T cell responses might be attributed to their status of activat
Chemical activation of innate and specific immunity in contact dermatitis.: J Invest Dermatol. 2000 Aug;115(2):168-76. Unique Identifier : AIDSLINE MED/20409103; Zhang L; Tinkle SS; Toxicology and Molecular Biology Branch, National Institute for; Occupational Safety and Health, Centers for Disease Control and; Prevention, Morgantown, West Virginia 26505, USA.; Recent reports have suggested that chemical-induced allergic contact dermatitis may not be a traditional type IV hypersensitivity, in part due to the dual irritant and antigenic properties of sensitizing chemicals. In order to investigate the contribution of these properties to the molecular and cellular mechanism und
Peptide immunization indicates that CD8+ T cells are the dominant effector cells in trinitrophenyl-specific contact hypersensitivity.: J Invest Dermatol. 2000 Aug;115(2):260-6. Unique Identifier : AIDSLINE MED/20409115; Martin S; Lappin MB; Kohler J; Delattre V; Leicht C; Preckel T; Simon JC; Weltzien HU; Clinical Research Group, Department of Dermatology, University of; Freiburg, Freiburg, Germany. martin@haut.ukl.uni-freiburg.de; The identity of the effector T cell population involved in contact hypersensitivity is still questionable with evidence promoting both CD4+ or CD8+ T cells. Previous experimental studies have relied on the in vivo depletion of T cell subsets using antibody, or the use of knock-out mice with deficiencies in either CD4+
Expression of cutaneous lymphocyte-associated antigen regulated by a set of glycosyltransferases in human T cells: involvement of alpha1, 3-fucosyltransferase VII and beta1,4-galactosyltransferase I.: J Invest Dermatol. 2000 Aug;115(2):299-306. Unique Identifier : AIDSLINE MED/20409121; Nakayama F; Teraki Y; Kudo T; Togayachi A; Iwasaki H; Tamatani T; Nishihara S; Mizukawa Y; Shiohara T; Narimatsu H; Division of Cell Biology, Institute of Life Science, Soka; University, Tokyo, Japan.; Cutaneous lymphocyte-associated antigen (CLA), which plays a key part in skin homing of human CD4+ memory T cells via CLA/E-selectin binding, is upregulated by IL-12 and downregulated by IL-4. Although alpha1,3-fucosyltransferase VII is essential for synthesis of the CLA carbohydrate epitope, little is known about how
DTH responsiveness of HIV-infected Thai adults.: J Med Assoc Thai. 2000 Jun;83(6):633-9. Unique Identifier : AIDSLINE MED/20387861; Brown AE; Markowitz L; Nitayaphan S; Morgan P; Sukwit S; Chinaworapong S; Leelasupasri S; Birx D; Armed Forces Research Institute of Medical Sciences, Johns; Hopkins University, Baltimore, Maryland, USA.; A study was carried out in Thailand to determine the frequency of reactivity to delayed-type hypersensitivity (DTH) skin tests used for the staging of HIV patients in the United States . A four-antigen panel which included tetanus toxoid (1:10), Ca
Survival of children with AIDS: experience in a university hospital in northeast Thailand.: J Med Assoc Thai. 2000 Jun;83(6):652-6. Unique Identifier : AIDSLINE MED/20387864; Lumbiganon P; Kosalaraksa P; Loapaiboon M; Department of Pediatrics, Faculty of Medicine, Khon Kaen; University, Thailand.; The survival experience of pediatric AIDS patients from three points: birth, age at first symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46 males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-acquired pediatric AIDS. The children ca
Toxoplasma gondii antibody in HIV-infected persons.: J Med Assoc Thai. 2000 Jun;83(6):681-4. Unique Identifier : AIDSLINE MED/20387869; Sukthana Y; Chintana T; Lekkla A; Department of Protozoology, Faculty of Tropical Medicine, Mahidol; University, Bangkok, Thailand.; Toxoplasmosis in an immunocompromised host was not documented in Thailand until 1992 when HIV/AIDS infection became pandemic. Patients with toxoplasmic encephalitis and cerebral abscess were recorded, particularly from the northern part of the country. However, data on the preval
To tell or not to tell?: J Med Assoc Thai. 2000 Jun;83(6):698-700. Unique Identifier : AIDSLINE MED/20387873; Phaosavasdi S; Wilde H; Taneepanichskul S; Tannirandorn Y; Pruksapong C; Department of Obstetrics and Gynecology, Faculty of Medicine,; Chulalongkorn University, Bangkok, Thailand.
Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.: J Exp Med. 2000 Aug 7;192(3):325-36. Unique Identifier : AIDSLINE MED/20394040; Lohoff M; Duncan GS; Ferrick D; Mittrucker HW; Bischof S; Prechtl S; Rollinghoff M; Schmitt E; Pahl A; Mak TW; Institut fur Klinische Mikrobiologie und Immunologie,; Universitat Erlangen, 91054 Erlangen, Germany.; Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1-mediated transcriptional regulation of IFN-inducible genes. IRF-1(-/)- mice exhibit defective T helper type 1 (Th1) cell differentiation. We have used experimental leishmaniasis to show that, like IRF-1(-/)- mice, IRF-2(-/)-
X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells.: J Exp Med. 2000 Aug 7;192(3):337-46. Unique Identifier : AIDSLINE GENBANK/AJ245377; Parolini S; Bottino C; Falco M; Augugliaro R; Giliani S; Franceschini R; Ochs HD; Wolf H; Bonnefoy JY; Biassoni R; Moretta L; Notarangelo LD; Moretta A; Dipartimento di Scienze Biomediche e Biotecnologie, Universita; di Brescia, 25123 Brescia, Italy.; 2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function as a regulator of
Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2.: J Exp Med. 2000 Aug 7;192(3):347-58. Unique Identifier : AIDSLINE MED/20394042; Scanga CA; Mohan VP; Yu K; Joseph H; Tanaka K; Chan J; Flynn JL; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261,; USA.; Tuberculosis is a major cause of death in much of the world. Current estimates are that one-third of the world s population is infected with Mycobacterium tuberculosis. Most infected persons control the infection but in many cases may not eliminate the organism. Reactivation of this clinically latent infection is resp
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction.: J Exp Med. 2000 Aug 7;192(3):393-404. Unique Identifier : AIDSLINE MED/20394046; Babbe H; Roers A; Waisman A; Lassmann H; Goebels N; Hohlfeld R; Friese M; Schroder R; Deckert M; Schmidt S; Ravid R; Rajewsky K; Institute for Genetics, Institute for Pathology, University of; Cologne, 50931 Cologne, Germany.; Clonal composition and T cell receptor (TCR) repertoire of CD4(+) and CD8(+) T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution at the level of single cells. Individual CD4(+) or CD8(+) T cells were isolated from frozen sections of lesional tissue
Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio.: J Exp Med. 2000 Aug 7;192(3):405-12. Unique Identifier : AIDSLINE MED/20394047; Tanaka H; Demeure CE; Rubio M; Delespesse G; Sarfati M; Allergy Research Laboratory, Centre de Recherche du Centre; Hospitalier de l'Universite de Montreal (CHUM), Notre-Dame; Hospital, Montreal University, Montreal, Quebec H2L 4M1, Canada.; The subset of dendritic cells (DCs) and the nature of the signal inducing DC maturation determine the capacity of DCs to generate polarized immune responses. In this study, we show that the ability of human monocyte-derived DCs (myeloid DC(1)) to promote T helper type 1 (Th1) or Th2 differentiation was also found to b
Destruction of primary CD4(+) T cells by cell-cell interaction in human immunodeficiency virus type 1 infection in vitro.: J Gen Virol. 2000 Aug;81 Pt 8:1907-11. Unique Identifier : AIDSLINE MED/20381162; Stocker H; Scheller C; Jassoy C; Institute for Virology and Immunobiology, University of; Wurzburg, Versbacher Strasse 7, 97078 Wurzburg, Germany.; Infection of CD4(+) T lymphocytes with human immunodeficiency virus (HIV) in vitro is accompanied by extensive cytopathicity. The mechanism of cell death is unclear, but may be related to expression of the viral envelope glycoprotein. Here, it is demonstrated that T cell destruction in primary T cells occurs upon cont
Phylogenetic analysis of human herpesvirus-8 in South Africa and identification of a novel subgroup.: J Gen Virol. 2000 Aug;81 Pt 8:2029-38. Unique Identifier : AIDSLINE +; Alagiozoglou L; Sitas F; Morris L; AIDS Virus Research Unit, National Institute for Virology and; Department of Virology, University of the Witwatersrand, Private; Bag X4, Sandringham 2131, Johannesburg, South Africa.; The incidence of Kaposi s sarcoma in South Africa is increasing in parallel with the human immunodeficiency virus type 1 epidemic. An 804 bp region in the ORF75 gene of 40 human herpesvirus-8 (HHV-8) isolates from South Africa was sequenced and the phylogenetic relationships were
On the control of late gene expression in Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8).: J Gen Virol. 2000 Aug;81 Pt 8:2039-47. Unique Identifier : AIDSLINE MED/20381178; Chang J; Ganem D; Howard Hughes Medical Institute and Departments of Microbiology; and Medicine, University of California, San Francisco, CA; 94143-0414, USA.; Herpesvirus late genes require viral DNA replication for maximal expression. Although late gene expression appears to require DNA replication in cis in alphaherpesviruses, studies in Epstein-Barr virus (EBV) suggest that this cis-requirement might not pertain to the gammaherpesviruses. Based on these findings, a syste
Hot-spot variations of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen and application in genotyping by PCR-RFLP.: J Gen Virol. 2000 Aug;81 Pt 8:2049-58. Unique Identifier : AIDSLINE GENBANK/AF192756; Zhang YJ; Deng JH; Rabkin C; Gao SJ; Departments of Pediatrics and Microbiology, The University of; Texas Health Science Center at San Antonio, 7703 Floyd Curl; Drive, San Antonio, TX 78229-3900, USA.; Kaposi s sarcoma-associated herpesvirus (KSHV, human herpesvirus-8) is aetiologically associated with Kaposi s sarcoma and several other lymphoproliferative disorders. The latent nuclear antigen (LNA) encoded by KSHV ORF73 has important functions in virus latent infection and shows molecular polymorphism. Sequence var
A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta.: J Nat Prod. 2000 Jun;63(6):825-9. Unique Identifier : AIDSLINE MED/20330211; Kirsch G; Kong GM; Wright AD; Kaminsky R; Institute for Pharmaceutical Biology, Technical University of; Braunschweig, Mendelssohnstrasse 1, D-38106 Braunschweig,; Germany.; From the CH(2)Cl(2) extract of the sponge Hyrtios cf. erecta, collected from Fiji , two new sesterterpenes, 1 and 2, and the known compounds isodehydroluffariellolide (3), homofascaplysin A (4), and fascaplysin (5) were isolated. The
Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART).: J Neurol Neurosurg Psychiatry. 2000 Sep;69(3):376-80. Unique Identifier : AIDSLINE MED/20404048; Maschke M; Kastrup O; Esser S; Ross B; Hengge U; Hufnagel A; Department of Neurology, University Clinic Essen, Hufelandstrasse; 55, 45122 Essen, Germany. matthias.maschke@uni-essen.de; OBJECTIVE: To determine the change of incidence and prevalence of neurological disorders caused by the human immunodeficiency virus (HIV) and opportunistic infections in HIV positive patients under treatment since the introduction of highly active antiretroviral therapy (HAART). METHODS: The data of all HIV infected p
The doctor-patient relationship and HIV-infected patients' satisfaction with primary care physicians.: J Gen Intern Med. 2000 Jul;15(7):462-9. Unique Identifier : AIDSLINE MED/20398575; Sullivan LM; Stein MD; Savetsky JB; Samet JH; Department of Epidemiology and Biostatistics, Boston University; Schools of Medicine and Public Health, MA 02115, USA.; lsull@bu.edu; OBJECTIVE: To assess the extent to which perceptions of specific aspects of the doctor-patient relationship are related to overall satisfaction with primary care physicians among HIV-infected patients. DESIGN: Longitudinal, observational study of HIV-infected persons new to primary HIV care. Data were collected at enr
Decreased immunoreactivity for cell-cycle regulator p27(Kip1) in Kaposi's sarcoma correlates with higher stage and extracutaneous involvement.: J Pathol. 2000 Aug;191(4):387-93. Unique Identifier : AIDSLINE MED/20379090; Fernandez-Figueras MT; Puig L; Penin RM; Mate JL; Bigata X; Ariza A; Department of Pathology, Hospital Universitari Germans Trias i; Pujol, Badalona, Spain.; A consistent relationship has been established between the development of Kaposi s sarcoma (KS) and human herpes virus-8 (HHV8) infection. HHV8-encoded v-cyclin, through its complexing with cyclin-dependent kinase 6, contributes to the phosphorylation and proteasome-mediated degradation of p27(Kip1). On the other hand
Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation.: J Pharmacol Exp Ther. 2000 Sep;294(3):1146-53. Unique Identifier : AIDSLINE MED/20404106; Gilbert KM; Wahid R; Fecher NP; Freeman JP; Fifer EK; Department of Microbiology and Immunology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; gilbertkathleenm@exchange.uams.edu; Compounds with the capacity to induce antigen-specific unresponsiveness in CD4(+) T cells can in some clinical situations be more beneficial than general immune suppressants. Newly synthesized ester, ester/amide, and amide derivatives of butyrate with the capacity to induce antigen-specific T cell unresponsiveness in
Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs.: J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. Unique Identifier : AIDSLINE MED/20404067; Wada S; Tsuda M; Sekine T; Cha SH; Kimura M; Kanai Y; Endou H; Department of Pharmacology and Toxicology, Kyorin University; School of Medicine, Mitaka, Tokyo, Japan.; Organic anion transporter 1 (OAT1) is a p-aminohippurate/dicarboxylate exchanger that plays a primary role in the tubular secretion of endogenous and exogenous organic anions. OAT1 is located in the basolateral membrane of the proximal tubular cells and mediates the uptake of various organic anions from the peritubula
Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation.: J Reprod Immunol. 2000 Jul;47(2):121-38. Unique Identifier : AIDSLINE MED/20384918; Hayakawa S; Fujikawa T; Fukuoka H; Chisima F; Karasaki-Suzuki M; Ohkoshi E; Ohi H; Kiyoshi Fujii T; Tochigi M; Satoh K; Shimizu T; Nishinarita S; Nemoto N; Sakurai I; Department of Obstetrics and Gynaecology, Nihon University School; of Medicine, Tokyo, Japan. satoshih@med.nihon-u.ac.jp; It has been proposed that immune responses in mammalian normal pregnancy are Th2-like, thereby protecting the fetus and placenta from being rejected. Administration of exogenous Th1 cytokines into pregnant mice is reported to induce feto-placental resorption. However, the effects of exogenous Th2 cytokines and Th2 dir
HTLV-I transmission from mother to child.: Unique Identifier : AIDSLINE MED/20384923; Fujino T; Nagata Y; School of Health Sciences, Faculty of Medicine, Kagoshima; University, Japan. toshinet@health.nop.kagoshima-u-ac-jp; Human T-lymphotropic virus type I (HTLV-I), a causative agent of adult T-cell leukemia, (ATL) is transmitted from mother to child. ATL cells originate from the CD4 subset of peripheral T cells. The main route of mother-to-child transmission is postnatal breast-feeding. Refraining from breast-feeding or limiting the du
DoMCoSAR: a novel approach for establishing the docking mode that is consistent with the structure-activity relationship. Application to HIV-1 protease inhibitors and VEGF receptor tyrosine kinase inhibitors.: J Med Chem. 2000 Aug 10;43(16):3020-32. Unique Identifier : AIDSLINE MED/20413481; Vieth M; Cummins DJ; Eli Lilly and Company, Lilly Research Laboratories, Lilly; Corporate Center, DC 1513, Indianapolis, Indiana 46285, USA.; m.vieth@lilly.com; DoMCoSAR is a novel approach for statistically determining the docking mode that is consistent with a structure-activity relationship. The approach establishes the binding mode for the compounds in a chemical series with the assumption that all molecules exhibit the same binding mode. It involves three stages. In the
Increased neutralization sensitivity and reduced replicative capacity of human immunodeficiency virus type 1 after short-term in vivo or in vitro passage through chimpanzees.: J Virol. 2000 Sep;74(17):7699-707. Unique Identifier : AIDSLINE MED/20392121; Beaumont T; Broersen S; van Nuenen A; Huisman HG; de Roda Husman AM; Heeney JL; Schuitemaker H; Department of Clinical Viro-Immunology, University of Amsterdam,; Academic Medical Center, Amsterdam, The Netherlands.; Development of disease is extremely rare in chimpanzees when inoculated with either T-cell-line-adapted neutralization-sensitive or primary human immunodeficiency virus type 1 (HIV-1), at first excluding a role for HIV-1 neutralization sensitivity in the clinical course of infection. Interestingly, we observed that sh
Polarization of allogeneic T-cell responses by influenza virus-infected dendritic cells.: J Virol. 2000 Sep;74(17):7738-44. Unique Identifier : AIDSLINE MED/20392125; Oh S; Eichelberger MC; Center for Immunization Research, Department of International; Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.; The developing immune response in the lymph nodes of mice infected with influenza virus has both Th1- and Th2-type characteristics. Modulation of the interactions between antigen-presenting cells and T cells is one mechanism that may alter the quality of the immune response. We have previously shown that the ability o
Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus.: J Virol. 2000 Sep;74(17):7745-54. Unique Identifier : AIDSLINE MED/20392126; Murphy CG; Lucas WT; Means RE; Czajak S; Hale CL; Lifson JD; Kaur A; Johnson RP; Knipe DM; Desrosiers RC; Department of Microbiology and Molecular Genetics, Harvard; Medical School, Boston, Massachusetts 02115-5716, USA.; An effective vaccine for AIDS may require development of novel vectors capable of eliciting long-lasting immune responses. Here we report the development and use of replication-competent and replication-defective strains of recombinant herpes simplex virus (HSV) that express envelope and Nef antigens of simian immunod
DNA vaccines for influenza virus: differential effects of maternal antibody on immune responses to hemagglutinin and nucleoprotein.: J Virol. 2000 Sep;74(17):7787-93. Unique Identifier : AIDSLINE MED/20392131; Pertmer TM; Oran AE; Moser JM; Madorin CA; Robinson HL; Division of Microbiology and Immunology, Yerkes Primate Research; Center, Emory University, Atlanta, Georgia 30329, USA.; Maternal antibody is the major form of protection from disease in early life when the neonatal immune system is still immature; however, the presence of maternal antibody also interferes with active immunization, placing infants at risk for severe bacterial and viral infection. We tested the ability of intramuscular a
The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells.: J Virol. 2000 Sep;74(17):7794-802. Unique Identifier : AIDSLINE MED/20392132; Darcissac EC; Truong MJ; Dewulf J; Mouton Y; Capron A; Bahr GM; Laboratoire d'Immunologie Moleculaire de l'Infection et de; l'Inflammation, Institut Pasteur de Lille, Tourcoing, France.; Macrophages and dendritic cells are known to play an important role in the establishment and persistence of human immunodeficiency virus (HIV) infection. Besides antiretroviral therapy, several immune-based interventions are being evaluated with the aim of achieving better control of virus replication in reservoir cel
Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.: J Virol. 2000 Sep;74(17):7824-33. Unique Identifier : AIDSLINE MED/20392135; Pierson T; Hoffman TL; Blankson J; Finzi D; Chadwick K; Margolick JB; Buck C; Siliciano JD; Doms RW; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; Latently infected resting CD4(+) T cells provide a long-term reservoir for human immunodeficiency virus type 1 (HIV-1) and are likely to represent the major barrier to virus eradication in patients on combination antiretroviral therapy. The mechanisms by which viruses enter the latent reservoir and the nature of the c
Simian-human immunodeficiency virus containing a human immunodeficiency virus type 1 subtype-E envelope gene: persistent infection, CD4(+) T-cell depletion, and mucosal membrane transmission in macaques.: J Virol. 2000 Sep;74(17):7851-60. Unique Identifier : AIDSLINE MED/20392138; Himathongkham S; Halpin NS; Li J; Stout MW; Miller CJ; Luciw PA; Center for Comparative Medicine, University of California, Davis,; California 95616, USA.; The envelope (env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) determines several viral properties (e.g., coreceptor usage, cell tropism, and cytopathicity) and is a major target of antiviral immune responses. Most investigations on env have been conducted on subtype-B viral strains, prevalent in North
Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus.: J Virol. 2000 Sep;74(17):7861-8. Unique Identifier : AIDSLINE MED/20392139; Hengel H; Reusch U; Geginat G; Holtappels R; Ruppert T; Hellebrand E; Koszinowski UH; Lehrstuhl Virologie, Max von Pettenkofer-Institut,; Ludwig-Maximilians-Universitat, 80336 Munich, Germany.; hengelh@rki.de; The mouse cytomegalovirus (MCMV) m152- and m06-encoded glycoproteins gp40 and gp48, respectively, independently downregulate major histocompatibility complex (MHC) class I surface expression during the course of productive MCMV infection in fibroblasts. As a result, presentation of
Role of viral persistence in retaining CD8(+) T cells within the central nervous system.: J Virol. 2000 Sep;74(17):7903-10. Unique Identifier : AIDSLINE MED/20392144; Marten NW; Stohlman SA; Bergmann CC; Departments of Neurology, Keck School of Medicine, University of; Southern California, Los Angeles, California 90033, USA.; The continued presence of virus-specific CD8(+) T cells within the central nervous system (CNS) following resolution of acute viral encephalomyelitis implicates organ-specific retention. The role of viral persistence in locally maintaining T cells was investigated by infecting mice with either a demyelinating, paralyt
Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein.: J Virol. 2000 Sep;74(17):7922-35. Unique Identifier : AIDSLINE MED/20392146; Edinger AL; Ahuja M; Sung T; Baxter KC; Haggarty B; Doms RW; Hoxie JA; Department of Pathology and Laboratory Medicine, Department of; Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 19104, USA.; In an attempt to generate broadly cross-reactive, neutralizing monoclonal antibodies (MAbs) to simian immunodeficiency virus (SIV), we compared two immunization protocols using different preparations of oligomeric SIV envelope (Env) glycoproteins. In the first protocol, mice were immunized with soluble gp140 (sgp140)
Detachment of human immunodeficiency virus type 1 from germinal centers by blocking complement receptor type 2.: J Virol. 2000 Sep;74(17):7997-8002. Unique Identifier : AIDSLINE MED/20392154; Kacani L; Prodinger WM; Sprinzl GM; Schwendinger MG; Spruth M; Stoiber H; Dopper S; Steinhuber S; Steindl F; Dierich MP; Institute for Hygiene and Social Medicine, University of; Innsbruck, A-6020 Innsbruck, Austria.; After the transition from the acute to the chronic phase of human immunodeficiency virus (HIV) infection, complement mediates long-term storage of virions in germinal centers (GC) of lymphoid tissue. The contribution of particular complement receptors (CRs) to virus trapping in GC was studied on tonsillar specimens fr
Membrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusion.: J Virol. 2000 Sep;74(17):8038-47. Unique Identifier : AIDSLINE MED/20392159; Suarez T; Gallaher WR; Agirre A; Goni FM; Nieva JL; Unidad de Biofisica (CSIC-UPV/EHU) and Departamento de; Bioquimica, Universidad del Pais Vasco, 48080 Bilbao, Spain.; We have identified a region within the ectodomain of the fusogenic human immunodeficiency virus type 1 (HIV-1) gp41, different from the fusion peptide, that interacts strongly with membranes. This conserved sequence, which immediately precedes the transmembrane anchor, is not highly hydrophobic according to the Kyte-D
Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue.: J Virol. 2000 Sep;74(17):8077-84. Unique Identifier : AIDSLINE MED/20392163; Grivel JC; Malkevitch N; Margolis L; Laboratory of Cellular and Molecular Biophysics, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892, USA.; Progression of human immunodeficiency virus (HIV) disease is associated with massive death of CD4(+) T cells along with death and/or dysfunction of CD8(+) T cells. In vivo, both HIV infection per se and host factors may contribute to the death and/or dysfunction of CD4(+) and CD8(+) T cells. Progression of HIV disease
Chimeric yellow fever/dengue virus as a candidate dengue vaccine: quantitation of the dengue virus-specific CD8 T-cell response.: J Virol. 2000 Sep;74(17):8094-101. Unique Identifier : AIDSLINE MED/20392165; van Der Most RG; Murali-Krishna K; Ahmed R; Strauss JH; Emory Vaccine Center and Department of Microbiology and; Immunology, Emory University School of Medicine, Atlanta, Georgia; 30322, USA. rgvande@emory.edu; We have constructed a chimeric yellow fever/dengue (YF/DEN) virus, which expresses the premembrane (prM) and envelope (E) genes from DEN type 2 (DEN-2) virus in a YF virus (YFV-17D) genetic background. Immunization of BALB/c mice with this chimeric virus induced a CD8 T-cell response specific for the DEN-2 virus prM a
The 5' RNA terminus of spleen necrosis virus stimulates translation of nonviral mRNA.: J Virol. 2000 Sep;74(17):8111-8. Unique Identifier : AIDSLINE MED/20392167; Roberts TM; Boris-Lawrie K; Center for Retrovirus Research, Comprehensive Cancer Center, The; Ohio State University, Columbus, Ohio 43210-1093, USA.; The RU5 region at the 5 RNA terminus of spleen necrosis virus (SNV) has been shown to facilitate expression of human immunodeficiency virus type 1 (HIV) unspliced RNA independently of the Rev-responsive element (RRE) and Rev. The SNV sequences act as a distinct posttranscriptional control element to stimulate gag RNA
Mink cell focus-forming murine leukemia virus infection induces apoptosis of thymic lymphocytes.: J Virol. 2000 Sep;74(17):8119-26. Unique Identifier : AIDSLINE MED/20392168; Yoshimura FK; Wang T; Yu F; Kim HR; Turner JR; Department of Immunology and Microbiology and the Karmanos Cancer; Institute, Wayne State University, Detroit, Michigan 48201, USA.; fyoshi@med.wayne.edu; In a previous study we identified the subpopulations of thymus cells that were infected by the lymphomagenic MCF13 murine leukemia virus (MLV) (F. K. Yoshimura, T. Wang, and M. Cankovic, J. Virol. 73:4890-4898, 1999) and observed an effect on thymus size by virus infection. In this report we describe our results which
Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.: J Virol. 2000 Sep;74(17):8140-50. Unique Identifier : AIDSLINE MED/20392171; Gillespie GM; Wills MR; Appay V; O'Callaghan C; Murphy M; Smith N; Sissons P; Rowland-Jones S; Bell JI; Moss PA; MRC Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford, United Kingdom.; ggillesp@molbiol.ox.ac.uk; Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described technique of staining antigen-specific CD8(+) T cells with peptide-HLA tetrameric complex
Moloney murine leukemia virus-induced tumors show altered levels of proapoptotic and antiapoptotic proteins.: J Virol. 2000 Sep;74(17):8151-8. Unique Identifier : AIDSLINE MED/20392172; Bonzon C; Fan H; Department of Molecular Biology and Biochemistry and Cancer; Research Institute, University of California, Irvine, California; 92697, USA.; Moloney murine leukemia virus (M-MuLV) is a replication-competent, simple retrovirus that induces T-cell lymphomas when inoculated into neonatal mice. The tumor cells are typically derived from immature T cells. During preleukemic times, a marked decrease in thymic size is apparent in M-MuLV-inoculated mice. We previo
Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.: J Virol. 2000 Sep;74(17):8159-65. Unique Identifier : AIDSLINE MED/20392173; Sherman MP; de Noronha CM; Pearce D; Greene WC; Gladstone Institute of Virology and Immunology, University of; California, San Francisco, California, USA.; Human immunodeficiency virus type 1 (HIV-1) Vpr participates in nuclear targeting of the viral preintegration complex in nondividing cells and induces G(2) cell cycle arrest in proliferating cells, which creates an intracellular milieu favorable for viral replication. Vpr also activates the transcription of several pr
Characterization of a replication-defective human immunodeficiency virus type 1 att site mutant that is blocked after the 3' processing step of retroviral integration.: J Virol. 2000 Sep;74(17):8188-93. Unique Identifier : AIDSLINE MED/20392177; Chen H; Engelman A; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, and Department of Pathology, Harvard Medical School,; Boston, Massachusetts 02115, USA.; Two activities of retroviral integrase, 3 processing and DNA strand transfer, are required to integrate viral cDNA into a host cell chromosome. Integrase activity has been analyzed in vitro using purified protein and recombinant DNA substrates that model the U3 and U5 ends of viral cDNA or by using viral preintegrati
Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors.: J Virol. 2000 Sep;74(17):8194-201. Unique Identifier : AIDSLINE GENBANK/AF254765; Lubyova B; Pitha PM; Oncology Center, The Johns Hopkins University School of Medicine,; Baltimore, Maryland 21231, USA.; The genome of the human herpesvirus 8 (HHV-8) contains a cluster of open reading frames (ORFs) encoding proteins with homology to the cellular transcription factors of the interferon regulatory factor (IRF) family. Two of these homologues, vIRF-1 and vIRF-2, were previously identified and functionally analyzed. In thi
Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes.: J Virol. 2000 Sep;74(17):8207-12. Unique Identifier : AIDSLINE MED/20392180; Cooper LJ; Kalos M; Lewinsohn DA; Riddell SR; Greenberg PD; Program in Immunology, Fred Hutchinson Cancer Research Center,; University of Washington, Seattle, Washington, USA. lcooper; The introduction of genes encoding T-cell receptor (TCR) chains specific for human immunodeficiency virus into T cells of infected patients represents a means to quantitatively and qualitatively improve immunity to the virus. Our results demonstrate that the high level of TCR expression required for physiologic functi
Partial penile disassembly and corporeal resection for Peyronie's disease with distal narrowing.: J Urol. 2000 Aug;164(2):449-50. Unique Identifier : AIDSLINE MED/20353538; Vo J; Wessells H; Section of Urology, University of Arizona College of Medicine,; Tucson, Arizona, USA.
B cell lymphomas of C57L/J mice; the role of natural killer cells and T helper cells in lymphoma development and growth.: Leuk Res. 2000 Aug;24(8):705-18. Unique Identifier : AIDSLINE MED/20396216; Erianne1 GS; Wajchman2 J; Yauch3 R; Tsiagbe VK; Kim BS; Ponzio NM; Department of Pathology and Laboratory Medicine, New Jersey; Medical School and Graduate School of Biomedical Sciences,; University of Medicine and Dentistry, 185 South Orange Avenue,; Newark, NJ 07103-2714, USA.; The Hodgkin s-like Type B neoplasms which arise spontaneously in aging C57L mice (25% incidence at 21 months of age) were first reported over 40 years ago, but since then relatively little has been published about these lymphomas. Based on previous studies in SJL mice, we investigated the phenotypic and functional pro
Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection.: Med Res Rev. 2000 Sep;20(5):323-49. Unique Identifier : AIDSLINE MED/20394119; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. erik.declerq@rega.kuleven.ac.be; A large variety of natural products have been described as anti-HIV agents, and for a portion thereof the target of interaction has been identified. Cyanovirin-N, a 11-kDa protein from Cyanobacterium (blue-green alga) irreversibly inactivates HIV and also aborts cell-to-cell fusion and transmission of HIV, due to its
Efficacy of voluntary HIV-1 counselling and testing in individuals and couples in Kenya, Tanzania, and Trinidad: a randomised trial. The Voluntary HIV-1 Counseling and Testing Efficacy Study Group [see comments]: Lancet. 2000 Jul 8;356(9224):103-12. Unique Identifier : AIDSLINE MED/20417236; BACKGROUND: Our aim was to determine the efficacy of HIV-1 voluntary counselling and testing (VCT) in reducing unprotected intercourse among individuals and sex-partner couples in Nairobi ( Kenya ), Dar es Salaam ( Tanzania ), and Port of
Cost-effectiveness of voluntary HIV-1 counselling and testing in reducing sexual transmission of HIV-1 in Kenya and Tanzania [see comments]: Lancet. 2000 Jul 8;356(9224):113-21. Unique Identifier : AIDSLINE MED/20417237; Sweat M; Gregorich S; Sangiwa G; Furlonge C; Balmer D; Kamenga C; Grinstead O; Coates T; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, MD 21205, USA. MSWEAT@JHSPH.EDU; BACKGROUND: Access to HIV-1 voluntary counselling and testing (VCT) is severely limited in less-developed countries. We undertook a multisite trial of HIV-1 VCT to assess its impact, cost, and cost-effectiveness in less-developed country settings. METHODS: The cost-effectiveness of HIV-1 VCT was estimated for a hypoth
What if we had an AIDS vaccine? [editorial]: Lancet. 2000 Jul 8;356(9224):85. Unique Identifier : AIDSLINE MED/20417227
HIV voluntary counselling and testing in community health services [comment]: Lancet. 2000 Jul 8;356(9224):86-7. Unique Identifier : AIDSLINE MED/20417228; Van de Perre P; Centre Muraz, Organisation de Coordination et de Cooperation; pour la lutte contre les Grandes Endemies, Bobo-Dioulasso,; Burkina Faso.
Male circumcision could help protect against HIV infection [news]: Lancet. 2000 Jul 15;356(9225):225. Unique Identifier : AIDSLINE MED/20417197; Clark S
Mbeki defiant about South African HIV/AIDS strategy [news]: Lancet. 2000 Jul 15;356(9225):225. Unique Identifier : AIDSLINE MED/20417196; Horton R
The importance of selenium to human health.: Lancet. 2000 Jul 15;356(9225):233-41. Unique Identifier : AIDSLINE MED/20417202; Rayman MP; Centre for Nutrition and Food Safety, School of Biological; Sciences, University of Surrey, Guildford, UK.; The essential trace mineral, selenium, is of fundamental importance to human health. As a constituent of selenoproteins, selenium has structural and enzymic roles, in the latter context being best-known as an antioxidant and catalyst for the production of active thyroid hormone. Selenium is needed for the proper funct
Targets now set by G8 countries to reduce "diseases of poverty".: Lancet. 2000 Jul 29;356(9227):408. Unique Identifier : AIDSLINE MED/20426199; Watts J
200 junior doctors sacked in Zambia [news]: Lancet. 2000 Jul 29;356(9227):410. Unique Identifier : AIDSLINE MED/20426201; Ahmad K
Evolution of gypsy endogenous retrovirus in the Drosophila obscura species group.: Mol Biol Evol. 2000 Aug;17(8):1185-93. Unique Identifier : AIDSLINE MED/20370946; Vazquez-Manrique RP; Hernandez M; Martinez-Sebastian MJ; de Frutos R; Departamento de Genetica, Facultad de Ciencias Biologicas,; Universitat de Valencia, Burjassot, Spain.; The Ty3/gypsy family of retroelements is closely related to retroviruses, and some of their members have an open reading frame resembling the retroviral gene env. Sequences homologous to the gypsy element from Drosophila melanogaster are widely distributed among Drosophila species. In this work, we report a phylogenet
Post meningitic sensori-neural hearing loss in children--alterations in hearing level.: Med J Malaysia. 1997 Sep;52(3):285-90. Unique Identifier : AIDSLINE MED/20423808; Yeat SW; Mukari SZ; Said H; Motilal R; Department of Otorhinolayngology, Universiti Kebangsaan Malaysia,; Kuala Lumpur.; Post meningitic sensori-neural hearing loss was studied in forty new cases of bacterial meningitis and ten cases of viral meningitis treated at the Pediatric Institute, Kuala Lumpur Hospital from April 1991 to March 1992. Hearing assessment at 2 weeks, 3 months and 6 months following the diagnosis of meningitis using
HIV in south and South-East Asia [editorial]: Med J Malaysia. 1997 Dec;52(4):311-2. Unique Identifier : AIDSLINE MED/20423814; Yasmin AM
Epidemiology and clinical characteristics of HIV-infected patients in Kuala Lumpur.: Med J Malaysia. 1997 Dec;52(4):313-7. Unique Identifier : AIDSLINE MED/20423815; Cheong I; Lim A; Lee C; Ibrahim Z; Sarvanathan K; Department of Medicine, Universiti Kebangsaan Malaysia.; Between 1987 to 1995, a total of 334 patients infected with HIV were treated at the Hospital Kuala Lumpur. There were 159 Malays, 108 Chinese, 64 Indians, and 3 from other ethnic groups. Three hundred and twenty-one (96.1%) of these individuals were males and 262 (65.9%) were between the ages of 26-45 years. Intraveno
Sexual behaviour and HIV knowledge among Dermatology cum Genitourinary Clinic attendees, Johor Bahru, Malaysia.: Med J Malaysia. 1997 Dec;52(4):318-24. Unique Identifier : AIDSLINE MED/20423816; Choon SE; Sapiah W; Ismail Z; Balan V; Department of Dermatology, Hospital Sultanah Aminah, Johor Bahru,; Malaysia.; A study was conducted in the Dermatology cum Genitourinary Clinic, Hospital Sultanah Aminah Johor Bahru to determine a local population s knowledge of HIV and their sexual behaviour in relation to it. A total of 231 men and 217 women were interviewed. The sexual culture seen is one of relatively late age of first sexu
A report of two non-AIDS associated Kaposi's sarcoma in Malaysia.: Med J Malaysia. 1997 Dec;52(4):437-40. Unique Identifier : AIDSLINE MED/20423833; Choon SE; Khoo JJ; Department of Dermatology, Hospital Sultanah Aminah, Johor Bahru,; Johor.; Kaposi s sarcoma is an uncommon cutaneous neoplasm seen classically in elderly males of East European or Jewish extract. It has been known to be endemic in sub-Saharan Africa for many years. Numerous cases had been described in patients on long-term immunosuppressive therapy and in patients living with acquired immuno
Drugs for non-HIV viral infections.: Med Lett Drugs Ther. 1999 Dec 3;41(1067):113-20. Unique Identifier : AIDSLINE MED/20437515
Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group [see comments]: N Engl J Med. 2000 Sep 14;343(11):759-66. Unique Identifier : AIDSLINE MED/20424000; Lipshultz SE; Easley KA; Orav EJ; Kaplan S; Starc TJ; Bricker JT; Lai WW; Moodie DS; Sopko G; McIntosh K; Colan SD; Division of Pediatric Cardiology, University of Rochester Medical; Center and Children's Hospital at Strong, University of Rochester; School of Medicine and Dentistry, NY 14642, USA.; steve_lipshultz@urmc.rochester.edu; BACKGROUND: Perinatal exposure to zidovudine may cause cardiac abnormalities in infants. We prospectively studied left ventricular structure and function in infants born to mothers infected with the human immunodeficiency virus (HIV) in order to determine whether there was evidence of zidovudine cardiac toxicity after
Perinatal exposure to zidovudine--benefits and risks [comment] [editorial]: N Engl J Med. 2000 Sep 14;343(11):803-5. Unique Identifier : AIDSLINE MED/20424008; Mofenson LM
Though HIV is the main cause of AIDS, other factors play a role [letter; comment]: Nature. 2000 Aug 17;406(6797):673. Unique Identifier : AIDSLINE MED/20417561; Oliver RT
Progression of autoimmune diabetes driven by avidity maturation of a T-cell population.: Nature. 2000 Aug 17;406(6797):739-42. Unique Identifier : AIDSLINE MED/20417590; Amrani A; Verdaguer J; Serra P; Tafuro S; Tan R; Santamaria P; Department of Microbiology and Infectious Diseases, Faculty of; Medicine, University of Calgary, Health Sciences Centre, Alberta,; Canada.; For unknown reasons, autoimmune diseases such as type 1 diabetes develop after prolonged periods of inflammation of mononuclear cells in target tissues. Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the avidity maturation of a prevailing
Membranous glomerulonephritis with nephrotic syndrome in a HIV positive patient--remarkable remission with triple therapy [letter].: Nephrol Dial Transplant. 2000 Jul;15(7):1097-8. Unique Identifier : AIDSLINE MED/20321070; Alarcon-Zurita A; Salas A; Anton E; Morey A; Munar MA; Losada P; Martinez J
Indinavir pharmacokinetics in haemodialysis [letter]: Nephrol Dial Transplant. 2000 Jul;15(7):1102-3. Unique Identifier : AIDSLINE MED/20321076; Izzedine H; Aymard G; Hamani A; Launay-Vacher V; Deray G
T-cell activation follows Th1 rather than Th2 pattern in haemodialysis patients.: Nephrol Dial Transplant. 2000 Aug;15(8):1217-23. Unique Identifier : AIDSLINE MED/20370976; Sester U; Sester M; Hauk M; Kaul H; Kohler H; Girndt M; Medical Department IV, Nephrology, University Homburg, Homburg,; Germany.; BACKGROUND: Patients on chronic intermittent haemodialysis (HD) show an impaired cellular and humoral immune response that clinically appears with frequent infectious complications and low vaccination responses. This immune defect strongly correlates with reduced in vitro proliferative responses of T cells. The defect
Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA.: Oncogene. 2000 Jul 27;19(32):3570-5. Unique Identifier : AIDSLINE MED/20406536; Reddy TR; Tang H; Xu W; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; Unlike cellular mRNA, retroviral mRNA bypasses the tight coupling of the splicing and nuclear export steps to allow the export of intron-containing viral RNA transcripts to the cytoplasm. Two distinct nuclear export pathways for retroviral mRNA have been described: a CRM-1 dependent pathway mediated by the HIV-1 Rev p
General effect of Sam68 on Rev/Rex regulated expression of complex retroviruses.: Oncogene. 2000 Aug 17;19(35):4071-4. Unique Identifier : AIDSLINE MED/20420815; Reddy TR; Xu WD; Wong-Staal F; Department of Medicine, University of California San Diego, La; Jolla, California, CA 92093-0665, USA.; We have previously demonstrated that overexpression of Sam68 functionally substitutes for, as well as synergizes with, HIV-1 Rev in RRE-mediated gene expression and virus replication. In addition, C-terminal deletion mutants of Sam68 exhibit a transdominant negative phenotype in HIV replication. We now report that Sam
Dental caries in HIV-infected children versus household peers: two-year findings.: Pediatr Dent. 2000 May-Jun;22(3):207-14. Unique Identifier : AIDSLINE MED/20306086; Tofsky N; Nelson EM; Lopez RN; Catalanotto FA; Fine DH; Katz RV; Department of Pediatric Dentistry, University of Medicine and; Dentistry-New Jersey Dental School, USA.; PURPOSE: This report will present a two-year comparison of the incidence and baseline prevalence of dental caries found in both the primary and permanent dentition among a cohort of HIV-infected children as compared to household peer control subjects who were not HIV-infected. METHODS: The subjects in this report were
Oral soft tissue manifestations in HIV-positive vs. HIV-negative children from an inner city population: a two-year observational study.: Pediatr Dent. 2000 May-Jun;22(3):215-20. Unique Identifier : AIDSLINE MED/20306087; Barasch A; Safford MM; Catalanotto FA; Fine DH; Katz RV; University of Connecticut School of Dental Medicine, Farmington,; USA. barasaff@cs.com; PURPOSE: Data accrued after two years of longitudinal observation of oral soft tissue lesions in a cohort of HIV-infected children and comparisons to a group of uninfected controls is presented. SUBJECTS AND METHODS: One hundred and four HIV-positive subjects were enrolled from an inner city pediatric HIV clinic and H
Identification of Candida dubliniensis in a study of HIV-seropositive pediatric dental patients.: Pediatr Dent. 2000 May-Jun;22(3):234-8. Unique Identifier : AIDSLINE MED/20306092; Brown DM; Jabra-Rizk MA; Falkler WA Jr; Baqui AA; Meiller TF; Department of Pediatric Dentistry, University of Maryland Dental; School, Baltimore, USA.; PURPOSE: The combination of an immature immune system and suppressed cellular immunity in children with HIV infections provides optimal conditions for rapid disease progression. As a result, pediatric AIDS has become a major epidemiological challenge. Oral fungal colonization remains one of the most common opportunist
Induction of high level of specific antibody response to the neutralizing epitope ELDKWA on HIV-1 gp41 by peptide-vaccine.: Peptides. 2000 Apr;21(4):463-8. Unique Identifier : AIDSLINE MED/20283864; Liao M; Lu Y; Xiao Y; Dierich MP; Chen Y; Laboratory of Immunology, Research Centre of Medical Science and; the School of Life Science and Engineering, Tsinghua University,; 100084, Beijing, Peoples Republic of China.; The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was
A clinicopathological classification of granulomatous disorders.: Postgrad Med J. 2000 Aug;76(898):457-65. Unique Identifier : AIDSLINE MED/20368680; James DG; Royal Free Hospital School of Medicine, University of London, UK.; Granulomatous disorders comprise a large family sharing the histological denominator of granuloma formation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.
HIV infection and seizures [letter; comment]: Postgrad Med J. 2000 Aug;76(898):523-4. Unique Identifier : AIDSLINE MED/20368701; Gaspar G; Alvarez ML
Monte Carlo calculations on HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor 8-Cl TIBO: contribution of the L100I and Y181C variants to protein stability and biological activity.: Protein Eng. 2000 Jun;13(6):413-21. Unique Identifier : AIDSLINE MED/20336837; Smith MB; Lamb ML; Tirado-Rives J; Jorgensen WL; Michejda CJ; Ruby SK; Smith RH Jr; National Cancer Institute-FCRDC, P.O. Box B, Frederick, MD 21702,; USA.; A computational model of the non-nucleoside inhibitor 8-Cl TIBO complexed with HIV-1 reverse transcriptase (RT) was constructed in order to determine the binding free energies. Using Monte Carlo simulations, both free energy perturbation and linear response calculations were carried out for the transformation of wild-
Antiviral agent based on the non-structural protein targeting the maturation process of HIV-1: expression and susceptibility of chimeric Vpr as a substrate for cleavage by HIV-1 protease.: Protein Eng. 2000 Jun;13(6):431-6. Unique Identifier : AIDSLINE MED/20336839; Serio D; Singh SP; Cartas MA; Weber IT; Harrison RW; Louis JM; Srinivasan A; Department of Microbiology and Immunology, Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, PA 19107, USA.; The processing of precursor proteins (Gag and Gag-pol) by the viral protease is absolutely required in order to generate infectious particles. This prompted us to consider novel strategies that target viral maturation. Towards this end, we have engineered an HIV-1 virion associated protein, Vpr, to contain protease cl
Plasma protein binding properties of dimeric 4-aryl-1,4-dihydropyridines as novel non peptidic HIV-1 protease inhibitors.: Pharmazie. 2000 Jul;55(7):542-3. Unique Identifier : AIDSLINE MED/20401085; Hilgeroth A; Langner A; Institut fur Pharmazeutische Chemie, Fachbereich Pharmazie,; Martin-Luther-Universitat Halle-Wittenberg, Germany.; hilgeroth@pharmazie.uni-halle.de
Cerebrospinal fluid syndromes in HIV-positive patients with acute consciousness compromise.: Unique Identifier : AIDSLINE MED/20342324; Batista MS; Sesso RC; dos Reis-Filho JB; Departamento de Neurologia, Escola Paulista de Medicina (EPM),; Universidade Federal de Sao Paulo, Sao Paulo, Brasil.; We reviewed the cerebrospinal fluid (CSF) syndromes of 100 consecutive HIV-positive patients presenting acute consciousness compromise in emergency rooms, and correlated them with clinical data. The most frequent CSF syndromes were: absolute protein-cytological dissociation (21), viral (19), neurocryptococcosis (7), r
[Concurrent leishmaniasis and human immunodeficiency virus (HIV) infection: a study of four cases]: Rev Soc Bras Med Trop. 1999 Nov-Dec;32(6):713-9. Unique Identifier : AIDSLINE MED/20342328; Borges AS; Machado AA; Ferreira MS; de Castro Figueiredo JF; Silva GF; Cimerman S; Bacha HA; Teixeira MC; Departamento de Clinica Medica, Universidade Federal de; Uberlandia, Uberlandia, MG, Brasil.; Few cases of concurrent leishmaniasis and HIV infection have been reported in Brazil , despite both infections being in expansion. Two cases of visceral leishmaniasis and two cases of mucocutaneous leishmaniasis are discussed. Disseminated skin and oral lesions were found in the pat
Bronchiolitis obliterans-organizing pneumonia: an Italian experience.: Respir Med. 2000 Jul;94(7):702-8. Unique Identifier : AIDSLINE MED/20380356; Cazzato S; Zompatori M; Baruzzi G; Schiattone ML; Burzi M; Rossi A; Ratta L; Terzuolo G; Falcone F; Poletti V; Dipartimento di Malattie del Torace, Citta di Bologna, Ospedale; Bellazia-Maggiore, Italy.; The purpose of this study was to describe the clinical features at onset and outcome and the diagnostic approach in subjects with bronchiolitis obliterans-organizing pneumonia (BOOP). Over a 7-year period we observed 78 cases of biopsy-proven bronchiolitis obliterans-organizing pneumonia, in which well documented clin
[AIDS information systems: limits and possibilities]: Rev Esc Enferm USP. 1999 Sep;33(3):305-12. Unique Identifier : AIDSLINE MED/20348232; Nichiata LY; Shima H; Departamento de Enfermagem em Saude Coletiva da Escola de; Enfermagem da USP.; The article makes an analysis of the current System of Information (SI) in AIDS, aiming the difficulties with that was confronted when looking for to characterize the way as it happened and it developed in 1995 the epidemic of the AIDS in the Regional Administration of Health of Pirituba-Perus (ARS-8) of the municipal
[Emergent diseases caused by viruses]: Rev Latinoam Microbiol. 1996 Jul-Dec;38(3-4):193-206. Unique Identifier : AIDSLINE MED/20388090; Ramos Garcia C; Mota Sanchez J; Departamento de Arbovirus, Instituto Nacional de Salud Publica,; Cuernavaca, Mor. cramos@insp3.insp.mx; In this work a review on viral emerging infectious diseases is discussed. Some examples such as hemorrhagic fevers diseases, the Acquired Immunodeficiency Syndrome (AIDS) and zoonotic diseases, are included. In this review are discussed the main factors influencing the widespread and geographic distribution of viral e
[Multiple medullary and extramedullary plasmacytomas in an HIV infected female patient]: Rev Med Interne. 2000 Jul;21(7):623-7. Unique Identifier : AIDSLINE MED/20398676; Delevaux I; Bernard N; Ramanampamonjy R; Morlat P; Lacoste D; Bonnet F; Bonnel C; Deminiere C; Beylot J; Service de medecine interne et de maladies infectieuses,; hopital Saint-Andre, Bordeaux, France.; INTRODUCTION: Before the HIV infection era, plasmocyte tumor rarely occurred in patients younger than 40 years of age. Less frequent than lymphomas, the incidence of these blood diseases has however substantially increased in HIV-infected patients. In these patients, in addition to onset at earlier age, their clinical
[An irresistible weight gain]: Rev Med Interne. 2000 Jul;21(7):635-6. Unique Identifier : AIDSLINE MED/20398679; Mercie P; Faure I; Viallard JF; Leng B; Pellegrin JL; Clinique de medecine interne et maladies infectieuses, hopital; du Haut-Leveque, CHU de Bordeaux, Pessac, France.
[Advice to HIV infected persons travelling to tropical or subtropical destinations]: Schweiz Med Wochenschr. 2000 Jul 11;130(27-28):1041-50. Unique Identifier : AIDSLINE MED/20410015; Oehler T; Buchel B; Hatz C; Furrer H; Ambulatorium fur Infektionskrankheiten, Inselspital PKT2 B,; Bern.; Many HIV-infected persons travel from temperate zones to (sub)tropical destinations. HIV-specific immigration issues, medical resources abroad and problems regarding travel with multiple medication need to be anticipated. When prescribing immunisations and specific chemoprophylaxis, the stage of immunodeficiency as we
Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing.: Science. 2000 Sep 1;289(5484):1564-6. Unique Identifier : AIDSLINE MED/20425275; Bourara K; Litvak S; Araya A; Laboratoire de Replication et Expression des Genomes Eucaryotes; et Retroviraux, UMR 5097, CNRS-Universite Victor; Segalen-Bordeaux 2, France.; RNA editing involves posttranscriptional alterations of messenger RNA (mRNA) sequences modifying the information content encoded by the genetic message. Here, it is shown that, in chronically infected H9 cells, human immunodeficiency virus-type 1 (HIV-1) mRNAs undergo guanine-to-adenine (G-to-A) and cytosine-to-uracil
Uncertainties in predicting the demographic impact of AIDS.: Theor Popul Biol. 2000 Jun;57(4):309-24. Unique Identifier : AIDSLINE MED/20362007; Kault D; Department of Mathematics and Statistics, James Cook University,; Townsville, Queensland, 4811, Australia.; A model giving the demographic impact of AIDS is analysed to examine the sensitivity of the projections when various complicating features are included. The model deals with age and sexual partner change rate as continuous variables and uses a device to specify arbitrary correlations between the ages of the people who
Mother-to-infant transmission of GB virus type C/HGV.: Transfusion. 2000 Jun;40(6):725-30. Unique Identifier : AIDSLINE MED/20325510; Ohto H; Ujiie N; Sato A; Okamoto H; Mayumi M; Division of Blood Transfusion and Transplantation Immunology, the; Neonatal Intensive Care Unit, Fukushima Medical University,; Fukushima, Japan. hit-ohto@cc.fmu.ac.jp; BACKGROUND: The potentially hepatotropic flavivirus-like virus, GB virus type C (GBV-C)/HGV, has been detected in a few patients with acute and chronic hepatitis and in a certain proportion of blood donors and recipients of blood or blood components. STUDY DESIGN AND METHODS: Sera from 2979 pregnant Japanese women wer
Public perception of the risk of blood transfusion.: Transfusion. 2000 Aug;40(8):1017-22. Unique Identifier : AIDSLINE MED/20418365; Finucane ML; Slovic P; Mertz CK; Decision Research, Eugene, Oregon 97401, USA.; finucane@decisionresearch.org; BACKGROUND: Health policymakers are concerned about the proportion of people who say they are unwilling to receive a blood transfusion. This article examines how social, cultural, and political factors affect the perceived risk of transfusions. STUDY DESIGN AND METHODS: Data were collected as part of a large national
Comparative performances of an HTLV-I/II EIA and other serologic and PCR assays on samples from persons at risk for HTLV-II infection.: Transfusion. 2000 Aug;40(8):924-30. Unique Identifier : AIDSLINE MED/20418351; Poiesz BJ; Dube S; Choi D; Esteban E; Ferrer J; Leon-Ponte M; de Perez GE; Glaser J; Devare SG; Vallari AS; Schochetman G; Department of Medicine, State University of New York, Health; Science Center, Syracuse, New York 13210, USA.; poieszb@mailbox.hscsyr.edu; BACKGROUND: HTLV-I and HTLV-II are related exogenous pathogenic human retroviruses. Until recently, ELISAs based on HTLV-I antigens have been used to screen for the presence of HTLV-I or II antibodies. The HTLV-I-based assays have not been as sensitive in detecting antibodies to HTLV-II as in detecting antibodies to H
Infectious disease markers in young blood donors. Retrovirus Epidemiology Donor Study.: Unique Identifier : AIDSLINE MED/20418356; Watanabe KK; Williams AE; Schreiber GB; Ownby HE; Westat, Inc., Rockville, Maryland 20850, USA. watanak1@westat.com; BACKGROUND: To evaluate whether the active recruitment of young donors of high school and college age could affect the safety of the blood supply, prevalence and incidence rates of infectious disease markers among donors aged 17 to 18 and 19 to 22 were compared to those in donors 23 years of age and older. STUDY DESIG
Genetic characterization of HIV type 1 and type 2 from Bissau, Guinea-Bissau (West Africa).: Virus Res. 2000 Jun;68(1):51-61. Unique Identifier : AIDSLINE +; Esteves A; Parreira R; Piedade J; Venenno T; Canas-Ferreira WF; Unidade de Virologia/UPMM, Instituto de Higiene e Medicina; Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96,; P-1349-008, Lisboa, Portugal. aidaesteves@ihmt.unl.pt; Previous studies from Guinea-Bissau (West Africa) have demonstrated a unique epidemiology with respect to both HIV-1 and HIV-2 infection. In order to evaluate the prevalence and dynamics of HIV-1 and HIV-2 subtypes in Bissau, the capital city of Guinea-Bissau, a cross-sectional st
Evaluation of human herpesvirus type 8 infection in childhood langerhans cell histiocytosis.: Am J Hematol. 2000 Aug;64(4):237-41. Unique Identifier : AIDSLINE MED/20372345; Jenson HB; McClain KL; Leach CT; Deng JH; Gao SJ; Department of Pediatrics, The University of Texas Health Science; Center, San Antonio, Texas 78229-3900, USA. jenson@uthscsa.edu; The etiology of Langerhans cell histiocytosis (LCH) is unknown. Viral causes, including human herpesvirus type 6 (HHV6), have been suggested but remain unproved. The recently discovered human herpesvirus type 8 (HHV8), the cause of Kaposi s sarcoma, infects dendritic cells in the bone marrow associated with multiple m
Type I and type II T-cell profiles in aplastic anemia and refractory anemia.: Am J Hematol. 2000 Aug;64(4):271-4. Unique Identifier : AIDSLINE MED/20372350; Tsuda H; Yamasaki H; Division of Clinical Hematology and Immunology, Kumamoto City; Hospital, Kumamoto, Japan. tsudasan@wc4.so-net.ne.jp; Immune-mediated suppression of hematopoiesis has been considered the most important mechanism in the development of idiopathic aplastic anemia (AA) and some types of myelodysplastic syndrome (MDS). Using flow cytometric analysis of intracellular cytokine expression at the single-cell level, we analyzed helper-T (Th) a
Depression of evoked electromyographic (EEMG) responses by propofol in a patient with human T-cell lymphotropic virus type I-associated myelopathy (HAM).: Anesth Analg. 2000 Sep;91(3):755-7. Unique Identifier : AIDSLINE MED/20417720; Nitahara K; Matsuyama M; Sakuragi T; Higa K; Department of Anesthesiology, School of Medicine, Fukuoka; University, Japan. nitahara@fukuoka-u.ac.jp; IMPLICATIONS: We report a patient with human T-cell lymphotropic virus type I-associated myelopathy. Although muscle strength in both of the upper extremities was normal in this patient, evoked electromyogram of the adductor pollicis was depressed by propofol at the induction of anesthesia.
Interruption of prophylaxis for major opportunistic infections in HIV-infected patients receiving triple combination antiretroviral therapy.: Ann Med Interne (Paris). 2000 May;151(3):163-8. Unique Identifier : AIDSLINE MED/20356882; Jubault V; Pacanowski J; Rabian C; Viard JP; Service d'Immunologie Clinique, Hopital Necker, 149-161, rue de; Sevres, 75743 Paris Cedex 15, France.; Interruption of prophylaxis for major opportunistic infections in HIV-infected patients receiving triple combination antiretroviral therapy. OBJECTIVE: To determine whether HIV-infected patients receiving highly active antiretroviral therapy (HAART) and recovering a CD4 cell number above 200x10(6)/l may safely discont
AIDS-dedicated nurses: what can be learned from their perceptions and experiences.: Appl Nurs Res. 2000 Aug;13(3):115-24. Unique Identifier : AIDSLINE MED/20416581; Sherman DW; New York University, Division of Nursing, New York, NY 10012,; USA. DAS1@is.nyu.edu; Throughout the history of the AIDS epidemic, the theoretical and empirical literature have emphasized the stressors related to the care of patients with AIDS and the reluctance of health professionals to provide AIDS care. Since the beginning, however, there have been individuals who dedicated themselves to the care o
HIV infection and in-hospital mortality at an academic hospital in South Africa.: Arch Dis Child. 2000 Sep;83(3):227-30. Unique Identifier : AIDSLINE MED/20408619; Zwi K; Pettifor J; Soderlund N; Meyers T; Division of Community Paediatrics, University of the; Witwatersrand, PO WITS 2050, South Africa. karen_zwi@bigpond.com; AIM: To document the impact that rapid increases in HIV infection in hospitalised children at Chris Hani Baragwanath Hospital has had on in-hospital mortality. METHODS: Hospital discharge summaries from January 1992 to the end of 1996 were reviewed. RESULTS: There were 20 733 admissions in the five year period; 7985 (
Ineffective control of murine cytomegalovirus by IE1-specific cytotoxic T lymphocytes during protracted infection in the lung.: Arch Virol. 2000;145(7):1291-304. Unique Identifier : AIDSLINE MED/20417328; Chen QJ; Yoshida H; Takimoto H; Ninomiya T; Ohtsu M; Kimura G; Nomoto K; Department of Immunology, Medical Institute of Bioregulation,; Kyushu University, Fukuoka, Japan.; Interstitial pneumonia caused by cytomegalovirus ( CMV ) is a fatal disease in immunocompromised patients. In order to examine the defense mechanism against the virus in the lung, we employed an intratracheal infection model in
Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro.: Biochem Biophys Res Commun. 2000 Jul 14;273(3):1025-32. Unique Identifier : AIDSLINE MED/20351220; Hirasawa K; Yoshida O; Fujinami T; Sohma K; Watanabe A; Viral Immunology Group, Central Research Laboratory of Fujirebio; Inc. , Hachioji, Tokyo, 192-0031, Japan.; keisuke-hirasawa@m05.htmnet.ne.jp; A novel strategy for anti-HIV therapy is the clearance of the residual infected cells from the body. Here, we show that 6-aminopurine, adenine, induced selective apoptosis toward HIV-1 producing chronically infected MOLT4 cells (MOLT4/HIV) without augmentation of virus production, whereas the growth of uninfected MOLT
Dialyzable leukocyte extract suppresses the activity of essential transcription factors for HIV-1 gene expression in unstimulated MT-4 cells.: Biochem Biophys Res Commun. 2000 Jul 14;273(3):1099-103. Unique Identifier : AIDSLINE MED/20351232; Ojeda MO; Fernandez-Ortega C; Rosainz MJ; Cell Biology Division, Center for Biological Research, Havana,; Cuba.; The human immunodeficiency virus type 1 (HIV-1) contains regulatory regions in its long terminal repeat (LTR) implicated in the control of viral gene expression. We previously demonstrated that Dialyzable Leukocyte Extract (DLE), a preparation derived from immune leukocytes, is able to inhibit HIV-1 replication in MT-
Human T-cell lymphotropic virus type-I tax gene induces interleukin-8 secretion by autocrine mechanism and has No effect on interleukin-16 in transfected Jurkat cells.: Biochem Biophys Res Commun. 2000 Jul 14;273(3):865-9. Unique Identifier : AIDSLINE MED/20351192; Zhang L; Sharma V; Laboratory of Cytokine Research, University of West Florida,; Pensacola, Florida 32514, USA.; Human T-cell lymphotropic virus I (HTLV-I) Tax has been shown to transactivate several cellular genes. In this study, we show that interleukin-8 (IL-8) is expressed and secreted in tax-transfected Jurkat cells that were further augmented by mitogen stimulation. Expression of high-affinity IL-8-R (Type A) mRNA in these
Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors.: Arzneimittelforschung. 2000 Jun;50(6):564-8. Unique Identifier : AIDSLINE MED/20375525; Marastoni M; Bazzaro M; Bortolotti F; Tomatis R; Department of Pharmaceutical Sciences, University of Ferrara,; Italy.; A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1 substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active th
Buyers' club list, December 1999.: AIDS Treat News. 1999 Dec 17;(No 333):3-4. Unique Identifier : AIDSLINE AIDS/20701059; Berkowitz J; Project Inform, CA.; This annual list of buyers clubs is published by AIDS Treatment News each December. Buyers clubs in eight States, the District of Columbia, and Canada are included. For each entry, there is full contact information, including telephone numbers, Web site, E- mail, and mailing addr
AIDS practice issues today: interview with Paul Bellman, M.D. [interview by John S. James]: AIDS Treat News. 2000 Apr 7;(No 340):1-6. Unique Identifier : AIDSLINE AIDS/20701060; Bellman P; Dr. Paul Bellman, a physician in private practice in Manhattan, treats many treatment-experienced HIV-infected patients. He discusses major issues in HIV/AIDS clinical care, including antiretroviral effectiveness and toxicity, possible treatment interruption, and immune-based treatment possibilities. Dr. Bellman belie
South Africa HIV dispute: time to stop and think.: AIDS Treat News. 2000 Apr 7;(No 340):6-8. Unique Identifier : AIDSLINE AIDS/20701061; James JS; A dispute between South African President Mbeki and AIDS experts in South Africa threatens to damage the World AIDS Conference in Durban. The controversy started with the governments reluctance to use AZT to prevent HIV transmission by pregnant women
Pfizer will donate Fluconazole to South Africa.: AIDS Treat News. 2000 Apr 7;(No 340):8. Unique Identifier : AIDSLINE AIDS/20701062; James JS; Pfizer Inc. will establish a program for the free distribution of fluconazole (Diflucan), a drug used to treat cryptococcal meningitis, known to occur in many people with AIDS, in South Africa . The drug s high cost has been a barrier t
2000 outlook.: AIDS Treat News. 2000 Jan 7;(No 334):2-4. Unique Identifier : AIDSLINE AIDS/20701063; James JS; An overview of important AIDS research areas and access to treatment issues is provided. Information on treatment overviews, HIV-specific immunity, antiretrovirals, lipodystrophy, and nutrition and supplements are briefly discussed. Other important issues mentioned include HIV/AIDS treatment in prisons and in developi
Disability benefits: new law will help disabled return to work.: AIDS Treat News. 2000 Jan 7;(No 334):7-8. Unique Identifier : AIDSLINE AIDS/20701064; James JS; A new Federal law, the Ticket to Work and Work Incentives Improvement Act of 1999, is expected to help disabled persons return to work without losing medical benefits, and prevent other problems associated with returning to work after becoming disabled. Three changes the law will impose in all States are listed. These
Flu epidemic: shots, new treatments available.: AIDS Treat News. 2000 Jan 21;(No 335):2-4. Unique Identifier : AIDSLINE AIDS/20701065; James JS; The flu can be more threatening to persons with HIV disease than to the general population. Persons with HIV disease need to contact their physician to determine if they should receive a flu shot. A physician should also provide information on how and when to obtain the shot, and the prevalence of an influenza epidemi
Post-exposure prevention (PEP) for sexual, needle exposure opens in New York.: AIDS Treat News. 2000 Jan 21;(No 335):6-7. Unique Identifier : AIDSLINE AIDS/20701066; Post-exposure prevention (PEP) involves a short treatment course of antiretrovirals within 72 hours of exposure to HIV through sex or intravenous needle sharing. This treatment was shown to reduce the chance of HIV infection by approximately 80 percent in health care workers exposed to HIV after a needlestick. Prevent
Retroviruses conference: overview, information available.: AIDS Treat News. 2000 Feb 4;(No 336):2-5. Unique Identifier : AIDSLINE AIDS/20701067; James JS; Using nutritional strategies to treat or possibly prevent the side effects of antiretroviral treatment was informally discussed at the 7th Conference on Retroviruses and Opportunistic Infections. The conference provided current information on mainstream HIV/AIDS treatments. There were conflicting presentations about d
Large cuts in public hospital, clinic HIV services, San Francisco and national -- why?: AIDS Treat News. 2000 Feb 4;(No 336):6-8. Unique Identifier : AIDSLINE AIDS/20701068; Mirken B; A projected cut in funding for the HIV/AIDS outpatient clinic at San Francisco General Hospital and other hospitals across the United States is due largely to changes in Federal Medicare and Medicaid programs. These reductions were included in the Balanced Budget Act (BBA) of 1997 to cl
New guidelines for HIV treatment; resistance testing now recommended.: AIDS Treat News. 2000 Feb 18;(No 337):5-6. Unique Identifier : AIDSLINE AIDS/20701070; The Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents was updated on January 28, 2000. A major change in the guidelines is that viral resistance testing is recommended in treating patients on failing regimens or those whose viral load remains higher than it should be. Resistance tel
Supreme Court leaves intact ruling permitting AIDS caps.: Unique Identifier : AIDSLINE AIDS/20701071; The U.S. Supreme Court let stand a ruling that allows insurance companies to cap AIDS-related benefits. The justices declined to hear an appeal in the case brought against Mutual of Omaha Insurance Company by two policy holders who said they received inferior coverage as a direct result of their HIV infection. The menl
Clinton opposes high court review of HIV inmate policy.: AIDS Policy Law. 2000 Jan 21;15(1):1,8. Unique Identifier : AIDSLINE AIDS/20701072; The Clinton Administration is urging the Supreme Court to allow Alabama to continue to exclude HIV-positive inmates from some prison activities because of the possibility that they might spread HIV to others. If the court accepts the administration s advice, the Alabama Department of Corrections will be able to restril
Ohio creates new felony for exposing sex partners to HIV.: AIDS Policy Law. 2000 Jan 21;15(1):2. Unique Identifier : AIDSLINE AIDS/20701073; Ohio House Bill 100 makes it a felony for a person who knows he or she has HIV to engage in sex without obtaining the partner s consent in advance. The bill was signed into law on December 23, 1999 by Gov. Bob Taft. The bill was sponsored by Rep. Ron Young, who says it is morally wrong for HIV-positive individuals to l
Insubordination, not HIV, triggered firing of food server.: AIDS Policy Law. 2000 Jan 21;15(1):3. Unique Identifier : AIDSLINE AIDS/20701074; An Illinois food server, Konrad Rotter, claimed that Chili s Grill & Bar fired him for being HIV-positive, but U.S. District Judge Philip Reinhard disagreed. The judge ruled that Rotter was fired for insubordination. Rotter was questioned by Chili s management after receiving complaints that the server had tubercul
Court overturns verdict in suit alleging contaminated Coke.: AIDS Policy Law. 2000 Jan 21;15(1):4. Unique Identifier : AIDSLINE AIDS/20701075; After Barbara Parker and Linda Hagan saw a gelatinous mass in the bottle of Coca-Cola they were drinking, they assumed the substance was a condom. They sued the Coca-Cola Bottling Company because they thought they may have ingested HIV, and won a $58,000 award. However, the Florida appeals court overturned the verdict
Mental health advocates complain about NIMH priority for AIDS. National Institute of Mental Health.: AIDS Policy Law. 2000 Jan 21;15(1):5. Unique Identifier : AIDSLINE AIDS/20701076; The National Alliance for the Mentally Ill is challenging the funding policies of the National Institute of Mental Health (NIMH), claiming that NIMH spends a disproportionate amount on AIDS research. A review of 2,277 abstracts of NIMH-funded projects in 1997 showed that the agency spent 14.2 percent of its budget stu
9th Circuit: ADA permits distinctions in group disability insurance plans.: AIDS Policy Law. 2000 Jan 21;15(1):6-7. Unique Identifier : AIDSLINE AIDS/20701077; The 9th U.S. Circuit Court of Appeals in San Francisco ruled that neither an insurer nor an employer can be subject to liability for benefits distinctions in group disability policies under the Americans with Disabilities Act (ADA). The ruling is seen as the most defendant-friendly decision yet on the topic. The rulin
Two 2nd Circuit decisions represent mixed bag on insurance.: AIDS Policy Law. 2000 Jan 21;15(1):7. Unique Identifier : AIDSLINE AIDS/20701078; The 2nd U.S. Circuit Court of Appeals in New York issued two important rulings within a week on the extent to which the Americans with Disabilities Act (ADA) regulates insurance practices. Pallozzi v. Allstate Life Insurance Co. was a plaintiff-friendly decision, finding that the insurance company illegally refused to
Blood bank association not liable for tainted transfusion.: AIDS Policy Law. 2000 Jan 21;15(1):9. Unique Identifier : AIDSLINE AIDS/20701079; The American Association of Blood Banks (AABB) is not liable for its early 1980s decision not to recommend AIDS screening for blood donors. The AABB is also not accountable for the HIV infection of an infant who received a blood transfusion during surgery. The transfusion occurred before blood testing for HIV was avai
Jury orders hospital to pay $250,000 for invasion of privacy.: AIDS Policy Law. 2000 Jan 21;15(1):10. Unique Identifier : AIDSLINE AIDS/20701080; The District of Columbia Superior Court awarded $250,000 to John Doe after Doe claimed a hospital employee accessed his confidential HIV test records and disclosed the diagnosis to Doe s friends and co-workers. Washington Hospital Center and one of its temporary employees, Tijuana Goldring, were found guilty of inva
HIV prophylaxis is deemed pertinent evidence in rape trial.: AIDS Policy Law. 2000 Jan 21;15(1):10. Unique Identifier : AIDSLINE AIDS/20701081; A Georgia trial judge acted properly in admitting into evidence the fact that a rape victim took an antiretroviral drug for six months following her attack. The victim, identified as J. A., was raped by an HIV-positive defendant, identified as Parks. Parks was found guilty of batt
Leniency denied because defendant was not debilitated by HIV infection.: AIDS Policy Law. 2000 Jan 21;15(1):11. Unique Identifier : AIDSLINE AIDS/20701082; The 6th U.S. Circuit Court of Appeals found no reason to shorten the sentence of an Ohio man because of his AIDS condition. Benjamin Owusu pleaded guilty to drug trafficking charges in the late 1980s and early 1990s, and cooperated with the government by testifying against others. However, he received a sentence more
Mover accused of bias.: AIDS Policy Law. 2000 Jan 21;15(1):12. Unique Identifier : AIDSLINE AIDS/20701083; A Massachusetts woman identified as Jane Doe has filed suit against A #1 Affordable Relocation Systems, alleging that the company refused to move her and her son s belongings because her son has AIDS. Doe hired the company for the move, but when the movers discovered her son had AIDS, they left the job and refunded he
Back-to-work bill signed.: AIDS Policy Law. 2000 Jan 21;15(1):12. Unique Identifier : AIDSLINE AIDS/20701084; President Clinton signed the Ticket to Work and Work Incentives Improvement Act in December. The law could make it possible for people with AIDS to go back to work without fear of losing their Medicaid or Medicare coverage. States will have the option of offering a Medicaid buy-in plan for workers with disabilities. T
Teacher loses suit.: AIDS Policy Law. 2000 Jan 21;15(1):12. Unique Identifier : AIDSLINE AIDS/20701085; Teacher William Ellsworth failed to prove he was rejected for a teaching position in Houston because he has HIV. U.S. District Judge Vanessa Gilmore found that the school district declined to hire Ellsworth because he scored poorly on a standardized oral test routinely given to applicants to forecast success in urban
18 months for biting.: AIDS Policy Law. 2000 Jan 21;15(1):12. Unique Identifier : AIDSLINE AIDS/20701086; Baltimore resident Eric Glaspie was sentenced to five years in prison, all but 18 months suspended, for biting a security guard during a department store scuffle. He was found guilty of a variety of charges, including reckless endangerment, second-degree assault, attempted petty theft, and passing a worthless check. T
Sergeant sentenced.: AIDS Policy Law. 2000 Jan 21;15(1):12. Unique Identifier : AIDSLINE AIDS/20701087; Sgt. Cornelius Abner was sentenced to two years in prison for forcible sodomy and other charges. Abner, who is HIV-positive, sexually assaulted another male sergeant at Fort Jackson, South Carolina. Abner was also convicted of breaking and entering, and disobeying an order by his commander to refrain from sexual conta
Government updates HIV treatment guidelines.: BETA. 1999 Jan;12(1):3. Unique Identifier : AIDSLINE AIDS/20701088; Highleyman L; The newly approved non-nucleoside reverse transcriptase inhibitor (NNRTI), efavirenz ( Sustiva ), was added to the Department of Health and Human Services (DHHS) Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents a
FDA approves abacavir. Food and Drug Administration.: BETA. 1999 Jan;12(1):3. Unique Identifier : AIDSLINE AIDS/20701089; Highleyman L; The Food and Drug Administration ( FDA ) approved Glaxo Wellcome s nucleoside analog, abacavir ( Ziagen , formerly 1592), for combination anti-HIV regimens for adults and children. In an early trial, abacavir was effectiv
IL-2 flushes out HIV.: BETA. 1999 Jan;12(1):4. Unique Identifier : AIDSLINE AIDS/20701090; Highleyman L; Researchers at the National Institute for Allergy and Infectious Diseases (NIAID) have shown that high doses of the cytokine interleukin-2 ( IL-2 ) in combination with three antiretroviral drugs were successful in eliminating replicating HIV from latent CD4 cells. Fourte
U.S. AIDS death rate decreases by nearly half.: BETA. 1999 Jan;12(1):5. Unique Identifier : AIDSLINE AIDS/20701091; Highleyman L; The Centers for Disease Control and Prevention s (CDC) National Center for Health Statistics announced that the rate of AIDS deaths in the U.S. decreased by 47 percent in 1997. AIDS fell from the first leading cause of death to fifth among adults ages 24-44. The dramatic decrease in AIDS deaths has been attributed to
Policy issues related to new metabolic abnormalities in HIV disease.: BETA. 1999 Jan;12(1):6,9. Unique Identifier : AIDSLINE AIDS/20701092; Baker R; www.HIVandHepatitis.com.; There is an emerging syndrome among people with HIV disease characterized by significant metabolic abnormalities. The syndrome, referred to as peripheral lipodystrophy, body-fat redistribution, and metabolic dysregulation, causes a loss of fat from the arms, legs, buttocks and face and an accumulation in the abdomen,
T-20: first of a new class of anti-HIV drugs.: BETA. 1999 Jan;12(1):7-8. Unique Identifier : AIDSLINE AIDS/20701093; Hanna L; T-20 is the most prominent of the new class of anti-HIV drugs, the fusion inhibitors. The drug, manufactured by Timeris, Inc., has extremely potent antiviral activity, and attacks HIV at a different point in its replication cycle than current antiretrovirals. T-20 is injected intravenously or taken by subcutaneous inf
Amprenavir: a new protease inhibitor nears approval.: BETA. 1999 Jan;12(1):8-9. Unique Identifier : AIDSLINE AIDS/20701094; Highleyman L; The new, second-generation protease inhibitor, amprenavir ( Agenerase ), discovered by Vertex Pharmaceuticals and clinically developed by Glaxo Wellcome , is awaiting regulatory approval in the U.S. and Europ
The challenge of adherence.: BETA. 1999 Jan;12(1):10-3. Unique Identifier : AIDSLINE AIDS/20701095; Chesney M; University of California at San Francisco.; The importance of adherence to antiretroviral drugs was the main topic of discussion at the 12th World AIDS Conference. Topics discussed include viral breakthrough and drug resistance, the widespread problem of nonadherence in increasing viral load, and factors associated with nonadherence. New treatments have led to
Adherence to HAART: an interview with William Holzemer. [interview by Tadd Tobias]: BETA. 1999 Jan;12(1):14-8. Unique Identifier : AIDSLINE AIDS/20701096; Holzemer W; University of California at San Francisco School of Nursing.; Issues relating to adherence to HAART are discussed in an interview with William Holzemer, R.N., Ph.D., director of the International Center for HIV/AIDS Research and Clinical Training in Nursing at the University of California at San Francisco (UCSF). Topics of discussion include demographics and predictors of adhere
Strategies for preventing late-term vertical HIV transmission.: BETA. 1999 Jan;12(1):19-22. Unique Identifier : AIDSLINE AIDS/20701097; Cadman J; Bentley-Salick Medical Practice, New York.; The significant decrease in HIV transmission rates from mother to child (vertical transmission) in developed countries is due largely to the implementation of the three-part AZT protocol. An abbreviated, two-part course of AZT preventive therapy has r
Body fat changes: more than lipodystrophy.: BETA. 1999 Jan;12(1):23-32. Unique Identifier : AIDSLINE AIDS/20701098; Hanna L; A wide range of body fat abnormalities has been reported in people with HIV/AIDS. Researchers speculate that protease inhibitors have specifically caused these changes. Various studies attempting to connect HAART and body fat changes have been conducted with mixed r
Current and planned research studies.: BETA. 1999 Jan;12(1):27-9. Unique Identifier : AIDSLINE AIDS/20701099; The Forum for Collaborative HIV Research (FCHR) sponsored a meeting to discuss HIV-related body fat changes and metabolic abnormalities. The goals of the meeting were to determine a working definition of the disorder and discuss the design of cross-sectional prevalence studies. Participants assembled a list of associa
Opportunistic infections...is it safe to stop prophylaxis?: BETA. 1999 Jan;12(1):33-41. Unique Identifier : AIDSLINE AIDS/20701100; Highleyman L; An opportunistic infection (OI) rarely affects people with healthy immune systems, but can be life-threatening to people whose immune systems are weakened by HIV. Prophylaxis is the use of drugs to prevent the occurrence or recurrence of a disease, such as an OI. Since the use of highly active antiretroviral therapy (
Highlights from recent conferences.: BETA. 1999 Jan;12(1):42-55. Unique Identifier : AIDSLINE AIDS/20701101; Bartnoff HS; The highlights from the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), the Fourth International Congress on Drug Therapy in HIV Infection (ICDTHI), and the 36th Infectious Disease Society of America (IDSA) Conferences are reported. The topics discussed include treatment guidelines, prot
Open clinical trials for HIV/AID treatments.: BETA. 1999 Jan;12(1):56-8. Unique Identifier : AIDSLINE AIDS/20701102; Townley D; San Francisco General Hospital, CA.; Information on various open clinical trails taken from the online database, Trial Search, is provided. The listings include research on HIV drug resistance, antiretroviral therapy, AIDS-related illnesses, pharmacokinetics, and treatment for children. Contact information for Trial Search and each study is provided.
New dosing of ddI (Videx) and Nelfinavir (Viracept) approved.: BETA. 1999;12(4):3. Unique Identifier : AIDSLINE AIDS/20701103; Highleyman L; The Food and Drug Administration ( FDA ) approved once-daily dosing of a new 200mg formulation of Bristol-Myers Squibb s nucleoside analog, ddI. The new tablet will be available in December 1999. Two tablets of ddI must always be taken together to minimize gastric acid degradation. The
Early access program for ABT-378/r.: BETA. 1999;12(4):3-4. Unique Identifier : AIDSLINE AIDS/20701104; Highleyman L; In September, Abbott Laboratories announced its expanded access program for ABT-378/r. The drug is a combination of the experimental protease inhibitor ABT-378 plus a small amount of ritonavir (
FDA panel fails to recommend adefovir approval. Food and Drug Administration.: BETA. 1999;12(4):4. Unique Identifier : AIDSLINE AIDS/20701105; Highleyman L; A Food and Drug Administration ( FDA ) advisory panel recommended against accelerated approval for adefovir dipivoxil (Preveon). The drug belongs to a new class of drugs, nucleotide reverse transcriptase inhibitors, and was developed by Gilead Sciences
Lodenosine trials stopped due to safety concerns.: BETA. 1999;12(4):4. Unique Identifier : AIDSLINE AIDS/20701106; Highleyman L; In October, a phase II trial of the nucleoside analog lodenosine was suspended after one participant died and others showed signs of liver or kidney damage. The drug was developed by U.S. Biosciences. The 176 persons in the trial who were taking the drug have stopped lodenosine treatment. Favorable results showing tha
First AIDS case in 1969.: BETA. 1999;12(4):5. Unique Identifier : AIDSLINE AIDS/20701107; Highleyman L; Researchers reported in August that they have discovered evidence that the first case of HIV infection in the U.S. occurred in the 1960s. Frozen serum and tissue samples from a 15-year-old African-American male prostitute were studied, and polymerase chain reaction (PCR) technology was used to analyze gene sequences.
New HIV/AIDS data presented at prevention conference.: BETA. 1999;12(4):6. Unique Identifier : AIDSLINE AIDS/20701108; Highleyman L; The Centers for Disease Control and Prevention (CDC) hosted its first National HIV Prevention Conference. CDC data presented at the conference shows that while the decline in U.S. AIDS deaths is not as steep as it had been, numbers of deaths are continuing to drop. The CDC attributes the decline to the introduction of
Detuned assay used to track recent infections.: BETA. 1999;12(4):6, 78. Unique Identifier : AIDSLINE AIDS/20701109; Highleyman L; The Centers for Disease Control and Prevention (CDC) introduced a new HIV testing strategy. The Serologic Testing Algorithm for Recent HIV Seroconversions (STAHRS) strategy uses the newly developed detuned ELISA HIV antibody test. The new test can detect HIV antibodies after about 120 days; the standard test detects a
Emivirine: an NRTI that functions as an NNRTI.: BETA. 1999;12(4):7-8. Unique Identifier : AIDSLINE AIDS/20701110; Cheonis N; Emivirine (MKC-442) structurally is a nucleoside analog (NRTI) molecule, but it functions as a non-nucleoside reverse transcriptase inhibitor (NNRTI). It inhibits HIV replication by binding to the reverse transcriptase viral enzyme. The drug is classified as an NNRTI and is the only anti-HIV drug to demonstrate this c
Antiretroviral pharmacology issues and management.: BETA. 1999;12(4):9-15. Unique Identifier : AIDSLINE AIDS/20701111; Piscitelli SC; Clinical Center Pharmacy Department, National Institutes of; Health, MD.; Physicians now have 14 different approved anti-HIV drugs to treat the disease, and the possible combinations can be overwhelming to both patients and doctors. In addition to these drugs, other agents, such as hydroxyurea and IL-2 , may be added to the treatment regimen.
Natural history and treatment of Hepatitis C.: BETA. 1999;12(4):16-29. Unique Identifier : AIDSLINE AIDS/20701112; Highleyman L; The majority of people with hepatitis C (HCV) develop chronic hepatitis, which can lead to complications such as scarring, cirrhosis, and liver cancer. There are approximately four million Americans infected with the virus each year, and because symptoms often do not appear for several years, hepatitis C is called a s
Conferences raise new questions about HAART use by women.: BETA. 1999;12(4):30-9, 53. Unique Identifier : AIDSLINE AIDS/20701113; Hanna L; The 1999 National Conference on Women and HIV/AIDS included a number of sessions on trends and developments in the treatment of HIV specific to women. Infection rates among women are rising faster than those for men, especially among African-American and Latina women. Summaries include sessions on disease progression
Status report on HIV vaccine development.: BETA. 1999;12(4):40-8, 53. Unique Identifier : AIDSLINE AIDS/20701114; Cheonis N; In May, the World Health Organization (WHO) declared AIDS to be the world s deadliest infectious disease, and estimated that 16,000 new infections occur every day around the world. Many experts say that a vaccine is essential to sustain a decrease in the number of new infections. Altho
HIV/AIDS in adolescence.: BETA. 1999;12(4):49-53. Unique Identifier : AIDSLINE AIDS/20701115; Szekeres G; Center for AIDS Prevention Studies, CA.; Adolescents are among the fastest growing populations of HIV-infected persons. Their access to adequate health care is complicated by their age, their financial resources, medical consent laws, and the societal demands placed on them. Also, little research has been done to determine the most effective treatment approa
HAART and experimental approaches to treatment.: BETA. 1999;12(4):54-5. Unique Identifier : AIDSLINE AIDS/20701116; Bartnof HS; Several sessions at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) addressed issues related to highly active antiretroviral therapy (HAART) and novel approaches to treatment. Topics summarized include planned treatment holidays to stimulate a person s natural immune response; measuri
Anti-HIV drug resistance testing.: BETA. 1999;12(4):55-7. Unique Identifier : AIDSLINE AIDS/20701117; Bartnof HS; Several sessions at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) addressed drug resistance testing. Dr. Charles Boucher of the University Hospital in Utrecht, The Netherlands , described five situations in which resistance testing is indicat
Anti-HIV therapies early in the pipeline.: BETA. 1999;12(4):57. Unique Identifier : AIDSLINE AIDS/20701118; Bartnof HS; Several sessions at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) described new anti-HIV therapies under development. Drugs discussed include entry inhibitors and transcription inhibitors, a new class of anti-HIV drugs. New non-nucleoside reverse transcriptase inhibitors, nucleoside
Anti-HIV therapy trials: new studies and follow-up of existing trials.: BETA. 1999;12(4):58-60. Unique Identifier : AIDSLINE AIDS/20701119; Bartnof HS; Several sessions at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) presented results of trials of anti-HIV drugs. ABT-378/r, a combination of the protease inhibitor ABT-378 with ritonavir , shows great promise. T-20 (
New anti-HIV drug interactions, toxicities, and dosing options.: BETA. 1999;12(4):60-3, 66. Unique Identifier : AIDSLINE AIDS/20701120; Bartnof HS; Several sessions at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) described interactions, toxicities, and dosing options of new anti-HIV drugs. Body fat redistribution (BFR) is a major problem for patients, and some sessions addressed changing from
HIV transmission.: BETA. 1999;12(4):66. Unique Identifier : AIDSLINE AIDS/20701121; Bartnof HS; A presentation at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) noted that people with genital warts have significantly higher levels of semen viral load than those without warts. Genital warts are caused by the human papillomavirus (HPV) and are very common among the general popula
OIs and cancers.: BETA. 1999;12(4):66. Unique Identifier : AIDSLINE AIDS/20701122; Bartnof HS; A study presented at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) demonstrates that Kaposi s sarcoma herpesvirus (KSHV) can be transmitted via saliva in deep oral kissing. Results of multivariate anal