2000

Immunopathological factors for vertical transmission of HIV-1.: Pathobiology. 2000 Mar-Apr;68(2):53-67. Unique Identifier : AIDSLINE MED/20340758; Edgeworth RL; Ugen KE; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa, FL 33612, USA.; With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevi
Department of Pediatric Hematology-Oncology in Crete.: Pediatr Hematol Oncol. 1996 Sep-Oct;13(5):397-9. Unique Identifier : AIDSLINE MED/20356014; Kalmanti M; Department of Pediatric Hematology/Oncology, University Hospital; of Heraklion, University of Crete Medical School, Greece.
Immune response of immunocompromised children with malignancies to a recombinant hepatitis B vaccine.: Pediatr Hematol Oncol. 1996 Sep-Oct;13(5):425-31. Unique Identifier : AIDSLINE MED/20356018; Polychronopoulou-Androulakaki S; Panagiotou JP; Kostaridou S; Kyratzopoulou A; Haidas S; Department of Paediatric Haematology/Oncology, Aghia Sophia; Children's Hospital, Athens, Greece.; The aim of this study was to interpret the antibody response to hepatitis B vaccination following an intensified four-dose schedule in 140 cancer patients who presented at our clinic between January 1, 1993 and December 31, 1994. According to therapy status, the patients were divided into two groups: group A consisted
The prevalence of human T-cell lymphotropic virus type I infection in patients with cutaneous malignancies [letter]: Br J Dermatol. 2000 Jun;142(6):1237. Unique Identifier : AIDSLINE MED/20307339; Kawabata H; Setoyama M; Hanada S; Uozumi K; Kanekura T; Kanzaki T
Papulonecrotic tuberculide in a human immunodeficiency virus type 1-seropositive patient [letter]: Br J Dermatol. 2000 Jul;143(1):232-3. Unique Identifier : AIDSLINE MED/20344586; Alsina M; Campo P; Toll A; Martinez E; Palou J; Herrero C
The role of lymphocytes in human dermal wound healing.: Br J Dermatol. 2000 Jul;143(1):59-65. Unique Identifier : AIDSLINE MED/20344533; Boyce DE; Jones WD; Ruge F; Harding KG; Moore K; West Midlands Regional Plastic, Cardiff, UK.; BACKGROUND: Animal experimental data indicate a requirement for functionally active T lymphocytes to allow optimal healing of dermal wounds. Little evidence exists to confirm that this is the case in humans. Lymphocyte involvement in regulation of healing is probably mediated by release of secreted cytokines/growth fa
Optimal blood donation screening annotation.: Br J Haematol. 2000 Jun;109(4):694-8. Unique Identifier : AIDSLINE MED/20387578; Seifried E; Roth WK; Institute of Transfusion Medicine and Immune Haematology, Blood; Donor Service Hessia, Frankfurt, Germany.
[Non-occupational postexposure prophylaxis to human immunodeficiency virus: a two sided sword? (editorial)]: Enferm Infecc Microbiol Clin. 2000 Mar;18(3):105-7. Unique Identifier : AIDSLINE MED/20362683; Pena JM; Arribas J
[Mycobacterium kansasii osteomyelitis in a patient infected by the human immunodeficiency virus (letter)]: Enferm Infecc Microbiol Clin. 2000 Mar;18(3):148-9. Unique Identifier : AIDSLINE MED/20362697; Martinez T; Creagh R; Saavedra JM; Merino D
[Amplicor HIV-1 monitor and NucliSens HIV-1 QT: comparison of two new techniques to determine the viral load of the human immunodeficiency virus type 1 (letter)]: Enferm Infecc Microbiol Clin. 2000 Mar;18(3):149-50. Unique Identifier : AIDSLINE MED/20362698; Martin-Montero MC; Dominguez-Perez JR; Garcia-Bermejo I
Antimicrobial and radical modulation activity of AV-07, a poly-herbal formula.: In Vivo. 2000 Mar-Apr;14(2):351-5. Unique Identifier : AIDSLINE MED/20295916; Satoh K; Sakagami H; Ida Y; Komatsu N; Fujimaki M; Nakashima H; Kanbara K; Gupta M; Sarma DN; Mitra SK; Analysis Center, School of Pharmaceutical Sciences, Showa; University, Shinagawa-ku, Japan.; An extract of AV-07 was investigated for various biological activities. Pretreatment of mice with the AV-07 extract significantly protected them from lethal infection with E. coli. ESR spectroscopy showed that the extract produced radicals under alkaline conditions and enhanced the radical intensity of sodium ascorbat
Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes.: Microsc Res Tech. 2000 Aug 1;50(3):229-35. Unique Identifier : AIDSLINE MED/20351320; Raza A; Rush Cancer Institute, Rush-Presbyterian-St. Luke's Medical; Center, Chicago, Illinois 60612-3515, USA.araza@rush.edu; An attempt has been made in this article to summarize the state-of-the-art clinical experience with the use of anti-TNF therapies in four diseased states with special emphasis on myelodysplastic syndromes. Given the central role of TNF-alpha in initiating and perpetuating the chronic damage produced in the diseased or
Effect of intercistronic length on internal ribosome entry site (IRES) efficiency in bicistronic mRNA.: Gene Expr. 1999;8(5-6):299-309. Unique Identifier : AIDSLINE MED/20401903; Attal J; Theron MC; Puissant C; Houdebine LM; Unite de Differenciation Cellulaire, Institut National de la; Recherche Agronomique, Jouy en Josas, France.; Specific structures found in the mRNA of picornavirus are known to allow a cap-independent translation. These structures, named internal ribosome entry sites (IRES), are also able to favor translation of the second cistron in bicistronic mRNAs. Their mechanism of action is not well understood. In the present study, tw
Ten-year survival analysis of a cohort of heroin addicts in Catalonia: the EMETYST project.: Addiction. 2000 Jun;95(6):941-8. Unique Identifier : AIDSLINE MED/20402904; Sanchez-Carbonell X; Seus L; Blanquerna Faculty of Psychology and Educational Sciences, Ramon; Llull University, Barcelona, Spain. xaviersc@blanquerna.url.es; AIMS: To determine mortality rates and immediate causes of death in a cohort of heroin addicts, and to compare them with other European samples. DESIGN: Longitudinal follow-up study of a cohort for 10.5 years (March/July 1985-December 1995). SETTING: Catalonia, Spain . PARTICIPANTS:
Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant.: Braz J Med Biol Res. 2000 Jul;33(7):779-89. Unique Identifier : AIDSLINE MED/20340943; Muccioli C; Belfort R Jr; Departamento de Oftalmologia, Escola Paulista de Medicina,; Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil.; eyebr@webmail.epm.br; The objective of this prospective study was to evaluate the efficacy and complications of the use of an intraocular sustained-release ganciclovir implant for the treatment of active cytomegalovirus ( CMV ) retinitis in AIDS pat
Molecular breeding of viruses [see comments]: Nat Genet. 2000 Aug;25(4):436-9. Unique Identifier : AIDSLINE MED/20392398; Soong NW; Nomura L; Pekrun K; Reed M; Sheppard L; Dawes G; Stemmer WP; Maxygen Inc., Redwood City, California, USA.; naywei_soong@maxygen.com; Genetic recombination is a major force driving the evolution of many viruses. Recombination between two copackaged retroviral genomes may occur at rates as high as 40% per replication cycle. This enables genetic information to be shuffled rapidly, leading to recombinants with new patterns of mutations and phenotypes.
Hospital response to DRG refinements: the impact of multiple reimbursement incentives on inpatient length of stay.: Health Econ. 2000 Jun;9(4):277-94. Unique Identifier : AIDSLINE MED/20320710; Gilman BH; Health Economics Research, Inc., Waltham, MA 02452, USA.; bgilman@her-cher.org; Recent research has warned that the introduction of Diagnosis Related Groups (DRGs) based on hospital treatment decisions will lead to an increase in the rate of marginal procedures and to a resumption of high medical expenditure growth rates. This paper explores the often contradictory effects of the multiple reimbur
Missed opportunities in Durban [editorial]: Nat Med. 2000 Aug;6(8):839. Unique Identifier : AIDSLINE MED/20392550
South African government continues policy of inactivity [news]: Nat Med. 2000 Aug;6(8):843. Unique Identifier : AIDSLINE MED/20392553; Birmingham K
HIV vaccine trials planned for Africa [news]: Nat Med. 2000 Aug;6(8):844. Unique Identifier : AIDSLINE MED/20392554; Birmingham K
NIAID funds new groups to develop HIV vaccines [news]: Nat Med. 2000 Aug;6(8):844. Unique Identifier : AIDSLINE MED/20392555; Watanabe ME
Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment [see comments]: Nat Med. 2000 Aug;6(8):904-9. Unique Identifier : AIDSLINE MED/20392581; Schuchert MJ; Wright RD; Colson YL; Department of Surgery, University of Pittsburgh Medical Center; Health System, University of Pittsburgh, Pittsburgh, Pennsylvania; 15261, USA.; The facilitating cell is a rare CD8+ bone marrow subpopulation that can enhance allogeneic hematopoietic stem cell engraftment across complete major histocompatibility complex barriers without inducing acute graft-versus-host disease. Here we describe a CD3epsilon-associated complex on the facilitating cell surface th
Fetal immunization by a DNA vaccine delivered into the oral cavity.: Nat Med. 2000 Aug;6(8):929-32. Unique Identifier : AIDSLINE MED/20392586; Gerdts V; Babiuk LA; van Drunen Littel-van den Hurk; Griebel PJ; Veterinary Infectious Disease Organization, University of; Saskatchewan, S7N 5E3 Saskatoon, Canada.; Infectious diseases are the main cause of neonatal morbidity and mortality in humans. The World Health Organization estimated that in 1995 approximately 8 million infants died within the first year of life from infectious diseases, including 5 million during the first week of life. Som
tRNA determinants for transcription antitermination of the Bacillus subtilis tyrS gene.: RNA. 2000 Aug;6(8):1131-41. Unique Identifier : AIDSLINE MED/20397808; Grundy FJ; Collins JA; Rollins SM; Henkin TM; Department of Microbiology, The Ohio State University, Columbus; 43210, USA.; Transcriptional regulation of the T box family of aminoacyl-tRNA synthetase and amino acid biosynthesis genes in Gram-positive bacteria is mediated by a conserved transcription antitermination system, in which readthrough of a termination site in the leader region of the mRNA is directed by a specific interaction with
[Changes in HIV-related attitudes and knowledge of teenagers following the Aulasida intervention in 1996-1997]: Rev Esp Salud Publica. 2000 Mar-Apr;74(2):163-76. Unique Identifier : AIDSLINE MED/20375380; Fernandez Garcia C; Molina Quilis R; Ramirez Sampedro C; Perez Perez E; Castilla Catalan J; Marrodan Girones J; Alcover Gimenez S; Tomas Dolz S; Centro de Salud Publica de Alzira, Valencia.; carmen.fernandez@sanidad.m400.gva.es; BACKGROUND: Schools being the ideal setting for carrying out Health Education activities, the aim of this study was that of pinpointing and quantifying the changes in attitudes and knowledge on the part of teenagers enrolled in school in Algemesi (Valencia) following an educational intervention regarding HIV infection
[Knowledge of AIDS of the medical students from three Mexican universities]: Rev Esp Salud Publica. 2000 Mar-Apr;74(2):177-87. Unique Identifier : AIDSLINE MED/20375381; Jarillo Soto EC; Delgadillo Gutierrez HJ; Granados Cosme JA; Universidad Autonoma Metropolitana-Xochimilco, Mexico.; jsec6322@cueyatl.uam.mx; BACKGROUND: The Hegemonic Medical Model is discussed and is articulated with the postulates of the sociology of the professions. The information takes Aids as a specific topic, because it involves the aspects of recent scientific development, of clinical and epidemiological importance and due to the research which is
[Drugs, Poverty and HIV: results regarding a provincial needle exchange program in Point de Reperes, Quebec]: Can J Public Health. 2000 May-Jun;91(3):176-80. Unique Identifier : AIDSLINE MED/20382978; Belanger D; Noel L; Alary M; Parent R; Poulin C; Claessens C; Unite de recherche en sante publique, Centre de recherche du; Pavillon CHUL-CHUQ, Quebec. dbelanger@cspq.qc.ca; In this study (n = 200), the characteristics of IDUs participating in a provincial needle exchange program (NEP) for more than 2 years (> 2 years) were compared with those of IDUs having participated for less than 2 years ( 2 years were more often recipients of wel
Verbal working memory in HIV-seropositive drug users.: J Int Neuropsychol Soc. 2000 Jul;6(5):548-55. Unique Identifier : AIDSLINE MED/20387846; Farinpour R; Martin EM; Seidenberg M; Pitrak DL; Pursell KJ; Mullane KM; Novak RM; Harrow M; VA Chicago Health Care System-West Side Division, Chicago,; Illinois, USA.; Recent evidence suggests that HIV-seropositive drug users are impaired on tasks of visuospatial working memory compared with drug users seronegative for HIV. In the current study we evaluated the performance of 30 HIV-seropositive male drug users and 30 risk-matched seronegative controls on two measures of verbal work
Risk awareness of HIV/AIDS among commercial farm workers in Zimbabwe.: Cent Afr J Med. 1999 Dec;45(12):316-20. Unique Identifier : AIDSLINE MED/20397003; Siziya S; Rusakaniko S; Tshimanga M; Marufu T; Department of Community Medicine, School of Medicine, University; of Zimbabwe, Avondale, Harare.; OBJECTIVE: To determine levels of perceived risk of HIV infection and the determinants of these perceptions among commercial farm workers. DESIGN: Cross sectional. SETTING: Commercial farms in Manicaland, Mashonaland Central, Mashonaland West and Mashonaland East provinces of Zimbabw
[Pneumonia in HIV-infected patients: clinical observations]: Unique Identifier : AIDSLINE MED/20401249; Wnuk A; Leszczyszyn-Pynka M; Bander D; Boron-Kaczmarska A; Kliniki Chorob Zakaznych Pomorskiej Akademii Medycznej w; Szczecinie.; OBJECTIVES: To determine the occurrence of pneumonias in HIV-infected patients in our hospital during 1990-1999; to evaluate the clinical significance of pneumonias in HIV-seropositive patients; to estimate the ethiology of pulmonary infection. MATERIALS AND METHODS: One hundred and two HIV-infected patients, 17 (16.6
Decreasing risk of viral transfusion-transmitted diseases in Croatia.: Croat Med J. 2000 Jun;41(2):191-6. Unique Identifier : AIDSLINE MED/20313040; Grgicevic D; Balija M; Pirc-Tiljak D; Mihaljevic I; Gjenero-Margan I; Zupancic-Salek S; Macek P; Croatian Institute of Transfusion Medicine, Zagreb, Croatia.; damir.grgicevic@hztm.tel.hr; AIM: To assess the risk of viral transfusion-transmitted infections in Croatia . METHODS: The following parameters were analyzed: frequency of blood donations repeatedly reactive for HBsAg and anti-HCV (1993-1999); blood donations co
Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha.: Clin Cancer Res. 2000 May;6(5):1671-7. Unique Identifier : AIDSLINE MED/20273332; Reuben JM; Lee BN; Johnson H; Fritsche H; Kantarjian HM; Talpaz M; Department of Laboratory Medicine, The University of Texas M.D.; Anderson Cancer Center, Houston 77030, USA.; jreuben@mdanderson.org; Chronic myelogenous leukemia (CML) is a disorder of the hematopoietic stem cell that results in malignant expansion of myeloid cells with a cytogenetic abnormality, the translocation between chromosomes 9 and 22 known as the Philadelphia chromosome. Treatment with IFN-alpha has proven to be an effective therapy, induc
[Knowledge, attitudes, and practices of Brazilian women treated in the primary health care system concerning sexually transmitted diseases]: Cad Saude Publica. 2000;16(## Suppl 1):103-12. Unique Identifier : AIDSLINE MED/20366516; Fernandes AM; de Gaspari Antonio D; Bahamondes LG; Cupertino CV; Departamento de Tocoginecologia, Pontificia Universidade; Catolica de Campinas, Brasil.; An increase has been observed in the prevalence of HIV infection among Brazilian women in recent years. This study focused on women s knowledge, attitudes, and practices towards prevention of sexually transmitted diseases (STDs) in the primary health care system in Campinas, Sao Paulo. Of the 249 women interviewed, 10
[Risk behavior among Brazilian Military conscripts, 1998: an study of HIV infections following socioeconomic differences]: Cad Saude Publica. 2000;16(## Suppl 1):113-28. Unique Identifier : AIDSLINE MED/20366517; Szwarcwald CL; Castilho EA; Barbosa A Jr; Gomes MR; Costa EA; Maletta BV; de Carvalho RF; de Oliveira SR; Chequer P; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; A study of HIV-related risk behavior was carried out in 1998 among Brazilian military conscripts aged 17-20 years. A sample of 30,318 subjects was selected in three strata, pertaining to counties from: 1) the North and Central-West (N/CW); 2) South (S); and the states of Rio de Janeiro and Sao Paulo. HIV prevalence ra
[Estimated number of orphans due to maternal AIDS in Brazil, 1987-99]: Cad Saude Publica. 2000;16(## Suppl 1):129-34. Unique Identifier : AIDSLINE MED/20366518; Szwarcwald CL; Andrade CL; Castilho EA; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; This study proposes a procedure to estimate the number of orphans due to maternal AIDS. The procedure estimates the number of orphans by calendar year, multiplying the cumulative fertility rate by the number of AIDS deaths among women aged 15-49 years. Because the procedure refers to the number of children that are al
[Estimated number of HIV-infected individuals aged 15-49 years in Brazil, 1998]: Cad Saude Publica. 2000;16(## Suppl 1):135-41. Unique Identifier : AIDSLINE MED/20366519; Szwarcwald CL; Castilho EA; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; This study estimates the number of HIV-infected individuals from 15 to 49 years of age in Brazil in 1998 based on sentinel population studies in pregnant women, with a selection bias in the sample. A principal components procedure was used to group 44 counties in homogeneous 13 clu
[Temporal study in AIDS-associated disease in Brazil, 1980-1999]: Cad Saude Publica. 2000;16(## Suppl 1):21-36. Unique Identifier : AIDSLINE MED/20366510; Guimaraes MD; Departamento de Medicina Preventiva e Social, Faculdade de; Medicina, Universidade Federal de Minas Gerais, Belo Horizonte,; MG, 30130-100, Brasil.; Trends in annual incidence of reported AIDS-associated opportunistic infections (OI/100 adults > 12 years old) among AIDS cases were estimated at the national level in Brazil from 1980 through May 1999. The analysis included chi-square and linear regression modeling. The opportunis
[Dynamic models and social networks: a review and reflections on their contribution to understanding the HIV epidemic]: Cad Saude Publica. 2000;16(## Suppl 1):37-51. Unique Identifier : AIDSLINE MED/20366511; Barbosa MT; Byington MR; Struchiner CJ; Departamento de Matematica e Estatistica, Universidade do Rio; de Janeiro, Brasil.; Due to certain specificities in the HIV epidemic, its spread has escaped the random transmission pattern of other infectious diseases. Observation of the epidemic has shown that individual behavior - relational patterns among individuals - plays a crucial role in HIV transmission and that strategies to prevent the epi
[AIDS in Brazil: a changing epidemic (editorial)]: Cad Saude Publica. 2000;16(## Suppl 1):4-5. Unique Identifier : AIDSLINE MED/20366508; Castilho EA; Bastos FI; Scwarcwald CL; Fonseca MG; Coordenacao Nacional de DST e AIDS, Ministerio da Saude.
[Classification by occupation of AIDS cases in Brazil - 1995]: Cad Saude Publica. 2000;16(## Suppl 1):53-64. Unique Identifier : AIDSLINE MED/20366512; Cassano C; de Medeiros Frias LA; Valente JG; Departamento de Epidemiologia e Metodos Quantitativos de Saude,; Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio; de Janeiro, Brasil.; Based on occupational classification of AIDS cases reported in Brazil in 1995 and recorded in the Data Base for Reported Diseases (SINAN), AIDS incidence rates were estimated per 100 thousand inhabitants by occupation, according to the 1991 National Census. Nationwide rates for emp
[AIDS and pauperization: principal concepts and empirical evidence]: Cad Saude Publica. 2000;16(## Suppl 1):65-76. Unique Identifier : AIDSLINE MED/20366513; Bastos FI; Szwarcwald CL; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; This paper discusses methodologies for analyzing relations between social inequalities, marginalization, prejudice, and vulnerability to HIV/AIDS, highlighting current difficulties and alternative research strategies. It also reviews the international and Brazilian literature, emphasizing: economic and macropolitical
[The spread of the AIDS epidemic in Brazil from 1987 to 1996: a spatial analysis]: Cad Saude Publica. 2000;16(## Suppl 1):7-19. Unique Identifier : AIDSLINE MED/20366509; Szwarcwald CL; Bastos FI; Esteves MA; de Andrade CL; Departamento de Informacoes em Saude, Centro de Informacao; Cientifica e Tecnologica, Fundacao Oswaldo Cruz, Rio de; Janeiro, Brasil.; Mean AIDS incidence rates were calculated for three time periods, 1987-89, 1990-92, and 1993-96, using reported adult AIDS cases by county. The analysis included the following variables: population of counties for resident AIDS cases ; proportion of population residing in urban areas , and concentration of poverty
[AIDS and level of education in Brazil: temporal evolution from 1986 to 1996]: Cad Saude Publica. 2000;16(## Suppl 1):77-87. Unique Identifier : AIDSLINE MED/20366514; Fonseca MG; Bastos FI; Derrico M; Andrade CL; Travassos C; Szwarcwald CL; Coordenacao Nacional de DST e AIDS, Ministerio da Saude,; Brasilia, Brasil.; This article analyzes the temporal distribution of reported AIDS cases by level of education used as a proxy variable for individual socioeconomic status. All AIDS cases aged 20-69 years and reported through May 29, 1999, with date of diagnosis between 1986-1996, were included in the study. Incidence rates were calcul
[Poverty and HIV/AIDS: anthropological and sociological aspects]: Cad Saude Publica. 2000;16(## Suppl 1):89-102. Unique Identifier : AIDSLINE MED/20366515; Parker R; Camargo KR Jr; Instituto de Medicina Social, Universidade do Estado do Rio de; Janeiro, Rio de Janeiro, Brasil.; Focusing on the HIV/AIDS epidemic as a summation of several epidemics coexisting in the same space and drawing on Brazilian epidemiological data, we argue that the epidemic there shows variations already described elsewhere, such as feminization, pauperization, juvenization and interiorization, as a result of the deep
Mutational analysis of HIV-1 gag proteins (review).: Int J Mol Med. 2000 Sep;6(3):265-9. Unique Identifier : AIDSLINE MED/20394235; Miyaura M; Yoshida A; Sakurai A; Fujita M; Koyama AH; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.; The mature Gag proteins of human immunodeficiency virus type 1 (HIV-1) are major components of infectious virions, and thought to carry out numerous functions throughout the HIV-1 replication cycle. We have recently generated numerous gag gene mutants of HIV-1 to genetically study the functions of the Gag proteins. Th
Soluble CD30 is more relevant to disease activity of atopic dermatitis than soluble CD26.: Clin Exp Immunol. 2000 Aug;121(2):187-92. Unique Identifier : AIDSLINE MED/20389919; Katoh N; Hirano S; Suehiro M; Ikenaga K; Yamashita T; Sugawara N; Yasuno H; Department of Dermatology, Kyoto Prefectural University of; Medicine, Kyoto, and Mitsubishi Kagaku Bio-Clinical Laboratories,; Inc., Tokyo, Japan. nkatoh@derm.kpu-m.ac.jp; It is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible co
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens.: Clin Exp Immunol. 2000 Aug;121(2):193-200. Unique Identifier : AIDSLINE MED/20389920; Ryan EJ; Nilsson L; Kjellman N; Gothefors L; Mills KH; Infection and Immunity Group, National University of Ireland,; Maynooth, Ireland.; Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also contributes to protection against Bordetella pertussis, and it has already been demonstrated that Pa in
CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene.: Clin Exp Immunol. 2000 Aug;121(2):210-5. Unique Identifier : AIDSLINE MED/20389922; Boesen M; Svane IM; Engel AM; Rygaard J; Thomsen AR; Werdelin O; Institute for Medical Microbiology and Immunology, Panum; Institute, University of Copenhagen, Copenhagen, Denmark.; An attempt was made to identify the selection pressures put upon a growing tumour by CD8+ T cells. To this end tumours induced with 3-methylcholanthrene in T cell-deficient nude mice and in congenic T cell-competent nu/+ mice were transplanted to nu/+ recipients. The rejection rate of the sarcomas from nude mice was a
Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7.: Clin Exp Immunol. 2000 Aug;121(2):216-25. Unique Identifier : AIDSLINE MED/20389923; Chu NR; Wu HB; Wu T; Boux LJ; Siegel MI; Mizzen LA; StressGen Biotechnologies Corporation, Victoria, B.C., Canada,; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, MD, USA. rchu@stressgen.com; Human papillomavirus type 16 (HPV16) infection has been linked to the development of cervical and anal dysplasia and cancer. One hallmark of persistent infection is the synthesis of the viral E7 protein in cervical epithelial cells. The expression of E7 in dysplastic and transformed cells and its recognition by the im
Characterization of T cell clones derived from lymph nodes and lungs of Pseudomonas aeruginosa-susceptible and resistant mice following immunization with heat-killed bacteria.: Clin Exp Immunol. 2000 Aug;121(2):275-82. Unique Identifier : AIDSLINE MED/20389931; Kondratieva TK; Kobets NV; Khaidukov SV; Yeremeev VV; Lyadova IV; Apt AS; Tam MF; Stevenson MM; Experimental Immunogenetics Laboratory, Central Institute for; Tuberculous and Laboratory for Immunochemistry, Shemyakin and; Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Pseudomonas aeruginosa-resistant BALB/c and susceptible C57Bl/6 (B6) mice were immunized with heat-killed Pseudomonas either in the foot pad or via the trachea, and panels of Pseudomonas-specific T cell clones were developed from lymph nodes and lungs. All clones from either strain, whether of lymph node or lung origi
Differential effect of cholera toxin on CD45RA+ and CD45RO+ T cells: specific inhibition of cytokine production but not proliferation of human naive T cells.: Clin Exp Immunol. 2000 Aug;121(2):283-8. Unique Identifier : AIDSLINE MED/20389932; Eriksson K; Nordstrom I; Czerkinsky C; Holmgren J; Department of Medical Microbiology and Immunology, Goteborg; University, Goteborg, Sweden and INSERM 4 U 364, Nice, France.; kristina.eriksson@microbio.gu.se; We have studied how cholera toxin (CT) and its non-toxic cell-binding B-subunit (CTB) affect the activation of pure human T cells in an anti-CD3-driven system. CT, as opposed to CTB, strongly suppressed the proliferative responses as well as cytokine production in CD4+ and CD8+ T cells. CT however, had a differential
Dysregulation in IL-12 secretion by neutrophils from HIV-infected patients.: Clin Exp Immunol. 2000 Aug;121(2):311-9. Unique Identifier : AIDSLINE MED/20389936; Vecchiarelli A; Monari C; Palazzetti B; Bistoni F; Casadevall A; Microbiology Section, Department of Experimental Medicine and; Biochemical Sciences, University of Perugia, Perugia, Italy.; vecchiar@unipg.it; It is generally believed that neutrophils from HIV-infected patients are functionally competent, but several studies have shown impairment in neutrophil fungal killing and cytokine production. In this study we evaluated the ability of neutrophils from healthy donors and HIV-infected patients to produce IL-12 in respon
High levels of IL-10 and determination of other cytokines and chemokines in HIV-associated haemophagocytic syndrome.: Clin Exp Immunol. 2000 Aug;121(2):320-3. Unique Identifier : AIDSLINE MED/20389937; Benveniste O; Dereuddre-Bosquet N; Clayette P; Leport C; Vilde JL; Dormont D; CEA, Service de Neurovirologie, CRSSA, DRM/DSV, Institut; Paris-Sud sur les Cytokines, B.P. 6, Fontenay aux Roses Cedex,; France. olivier.benveniste@psl.ap-hop-paris.fr; Haemophagocytic syndrome (HPS) and HIV infection are both associated with cytokine network dysregulation. We therefore analysed plasma levels and mRNA synthesis in peripheral blood mononuclear cells (PBMC) of cytokines, chemokines and chemokine receptors in one HIV-infected patient with HPS. We compared the results wi
Expression of MHC class II in T cells is associated with increased HIV-1 expression.: Clin Exp Immunol. 2000 Aug;121(2):324-31. Unique Identifier : AIDSLINE MED/20389938; Saifuddin M; Spear GT; Chang C; Roebuck KA; Department of Immunology/Microbiology, Rush University, Chicago,; IL, USA. msaifudd@rush.edu; HIV-1 replicates in activated T cells at significantly higher levels than in resting cells. Thus, certain molecules up-regulated during T cell activation appear to be important for HIV-1 replication. In this study, we present evidence suggesting that expression of MHC class II (class II) molecules on CD4+ T cells faci
Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry.: Clin Exp Immunol. 2000 Aug;121(2):332-8. Unique Identifier : AIDSLINE MED/20389939; Bendelja K; Gagro A; Bace A; Lokar-Kolbas R; Krsulovic-Hresic V; Drazenovic V; Mlinaric-Galinovic G; Rabatic S; Department of Cellular Immunology, Institute of Immunology,; University Hospital for Infectious Diseases, University; Children's Hospital, Division of Virology, Croatian National; Institute of Public Health, Zagrab, Croatia.; Acute RSV infection in infancy may produce some asthma-like symptoms and may be followed by a recurrent wheeze later in childhood. It has been proposed that RSV infection stimulates type-2 cytokine responses, resembling those found in atopy and asthma. Peripheral blood cells were obtained from RSV-infected infants (n
Absence of CD40-CD40 ligand interactions in X-linked hyper-IgM syndrome does not affect differentiation of T helper cell subsets.: Clin Exp Immunol. 2000 Aug;121(2):346-52. Unique Identifier : AIDSLINE MED/20389941; Uronen H; Callard RE; Immunobiology Unit, Institute of Child Health, University College; London, London, UK.; The aim of this study was to investigate the effect of absent CD40-CD40 ligand interactions in patients with X-linked hyper-IgM syndrome (XHIGM) on the generation of Th1 and Th2 immunity. Whole blood from patients and sex- and age-matched controls was stimulated with phorbol myristate acetate (PMA) and calcium ionopho
Structure and self-association of the Rous sarcoma virus capsid protein.: Structure Fold Des. 2000 Jun 15;8(6):617-28. Unique Identifier : AIDSLINE PDB/1EOQ; Kingston RL; Fitzon-Ostendorp T; Eisenmesser EZ; Schatz GW; Vogt VM; Post CB; Rossmann MG; Department of Biological Sciences, Purdue University, West; Lafayette, IN 47907, USA.; BACKGROUND: The capsid protein (CA) of retroviruses, such as Rous sarcoma virus (RSV), consists of two independently folded domains. CA functions as part of a polyprotein during particle assembly and budding and, in addition, forms a shell encapsidating the genomic RNA in the mature, infectious virus. RESULTS: The str
Science before the CD-ROM [editorial; comment]: Rev Med Virol. 2000 Jul-Aug;10(4):205-6. Unique Identifier : AIDSLINE MED/20351797; Griffiths PD
Experimental infection of monkeys with Langat virus II. Turnover of circulating virus, 1967 [classical article] [see comments]: Rev Med Virol. 2000 Jul-Aug;10(4):207-15. Unique Identifier : AIDSLINE MED/20351798; Nathanson N; Harrington B
Clinical uses of non-nucleoside reverse transcriptase inhibitors.: Rev Med Virol. 2000 Jul-Aug;10(4):217-29. Unique Identifier : AIDSLINE MED/20351799; Harris M; Montaner JS; AIDS Research Program, St. Paul's Hospital, Vancouver, B.C.,; Canada.; Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are currently available for treatment of HIV-1 as part of combination antiretroviral therapy. Oral dosing is administered three times daily for delavirdine (DLV), twice daily for
Incidence and impact of resistance against approved antiretroviral drugs.: Rev Med Virol. 2000 Jul-Aug;10(4):231-53. Unique Identifier : AIDSLINE MED/20351800; Pillay D; Taylor S; Richman DD; PHLS Antiviral Susceptibility Reference Unit, Division of; Immunity and Infection, University of Birmingham, Medical School,; UK.; More than 15 antiretroviral drugs are now available for clinical use, and have led to significant reductions in morbidity and mortality for HIV infected individuals. Nevertheless, antiviral drug resistance emerges to all these drugs, which limits their benefit. This review addresses the biological basis of antiretrovi
Novel compounds in preclinical/early clinical development for the treatment of HIV infections.: Rev Med Virol. 2000 Jul-Aug;10(4):255-77. Unique Identifier : AIDSLINE MED/20351801; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections, belong to one of the following classes: (i) nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), (ii) non-nucleoside reverse transcriptase inhibitors (NNRTIs) and (iii)
[Increased girth, thin arms. Unusual changes in HIV therapy (news)]: MMW Fortschr Med. 1999 Sep 9;141(36):62-3. Unique Identifier : AIDSLINE MED/20362232
[The right to expensive drugs. What is indicated cannot have economic limitations (interview)]: MMW Fortschr Med. 2000 Apr 27;142(17):43-4. Unique Identifier : AIDSLINE MED/20337187; Wimmer R
[Antiretroviral therapy. NNRTI (non-nucleoside reverse transcriptase inhibitor)]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:14-6. Unique Identifier : AIDSLINE MED/20321525
[Protease inhibitor saving alternatives]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:16-7. Unique Identifier : AIDSLINE MED/20321526
[Antiretroviral therapy. A brief profile of all available drugs]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:18-29. Unique Identifier : AIDSLINE MED/20321527; Jablonowski H; Stadtisches Klinikum Salzgitter, Medizinische Klinik.
[Non-nucleoside reverse transcriptase inhibitor as a fully viable alternative. Strong therapy start without protease inhibitor]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:30-3. Unique Identifier : AIDSLINE MED/20321528
[Pathogenesis of HIV infection as the key to eradication? New therapeutic approaches]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:34-9. Unique Identifier : AIDSLINE MED/20321529; Manegold C; Bernhard-Nocht-Institut fur Tropenmedizin, Klinische Abteilung,; Hamburg. manegold@bni.uni-hamburg.de; While the effectiveness of conventional antiviral treatment is well proven, its limitations are becoming more and more evident. New approaches are resulting from the decoding of the pathogenesis of HIV infection. Thus, for example, experimental studies are looking at drug-induced blockade of the co-receptors necessa
[Various triple therapies in direct comparison. New decision aids for initial therapy]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:40-2. Unique Identifier : AIDSLINE MED/20321530
[Nucleoside reverse transcriptase inhibitors. Sex-specific effectiveness and tolerance]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:42-3. Unique Identifier : AIDSLINE MED/20321531
[Public health economic aspects of antiretroviral therapy. Can we afford to do less?]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:45-9. Unique Identifier : AIDSLINE MED/20321532; Stoll M; Claes C; Schulte E; Korner T; von der Schulenburg JM; Schmidt R; Abteilung Klinische Immunologie, Medizinischen Hochschule; Hannover. Stoll.Matthias@Mh-Hannover.de; In Germany , politically motivated economic considerations are becoming even more important. In this connection, scientific research into the health system is not limited merely to a consideration of costs, but utilizes the same methods and conceptual models as economic research in
[Antiretroviral therapy. Update at the beginning of a new century]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:5-13. Unique Identifier : AIDSLINE MED/20321524; Jablonowski H; Med. Klinik am Stadt. Krankenhaus Salzgitter.; For antiretroviral therapy (ART) nucleoside reverse transcriptase inhibitors (NRTI), protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) are available, and are used in combination treatments. The use of PI is associated with new side
[New variations in highly active antiretroviral therapy. Simple combination as a promising option]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:50-2. Unique Identifier : AIDSLINE MED/20321533
[Second chance therapy. New protease inhibitor for salvage therapy]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:53. Unique Identifier : AIDSLINE MED/20321534
[HIV infection in childhood]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:54-7. Unique Identifier : AIDSLINE MED/20321535; Seel K; Grosch-Worner I; Universitatsklinikum, Humboldt-Universitat zu Berlin.; karen.seel@charite.de; As a result of preventive measures during pregnancy and improved antiretroviral combination treatment, the problem area of HIV infection in childhood has undergone a change in recent years. Thanks to intensive cooperation between obstetricians and pediatricians, mother-to-child transmission of HIV in
[HIV plus hepatitis C or Kaposi sarcoma. Treatment options in coinfection]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:58-9. Unique Identifier : AIDSLINE MED/20321536
[Chronic hepatitis C in HIV-infected patients. Unfavorable interaction of HIV and HCV infection]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:60-2. Unique Identifier : AIDSLINE MED/20321537; Mauss S; HIV coinfection promotes the progression of chronic hepatitis C. The increased hepatic mortality and improved life expectancy of HIV-positive patients warrants treatment of chronic hepatitis C in those infected with HIV. The treatment of hepatitis C considered standard for HIV-negative and, in principle, also for HIV-
[Osteonecrosis: a rare complication of HIV infection. Association with certain risk factors]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:64-7. Unique Identifier : AIDSLINE MED/20321538; Meyer D; Behrens G; Stoll M; Schmidt RE; Abteilung Klinische Immunologie, Medizinischen Hochschule; Hannover.; Osteonecrosis is a rare complication of HIV infection. The presumptive cause of the aseptic osteonecrosis is a disturbed blood supply to the bone. Most cases of osteonecrosis are associated with numerous risk factors, such as use of steroids, alcohol abuse, coagulopathies or metabolic derangements. Since conventional
[Lipodystrophy and metabolic disorders in anti-HIV therapy]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:68-71. Unique Identifier : AIDSLINE MED/20321539; Behrens GM; Stoll M; Schmidt RE; Abteilung fur Klinische Immunologie, Medizinische Hochschule; Hannover. Behrens.Georg@MH-Hannover.de; For the effective treatment of HIV infection, combinations of antiretroviral drugs that, at various points of attack, prevent viral replication are used. After the introduction of HIV-1 specific protease inhibitors , various metabolic complications and changes in bod
[The future of HIV therapy. Research pipelines are filled with options]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:72-9. Unique Identifier : AIDSLINE MED/20321540; Jablonowski H; Medizinische Klinik am Stadt. Krankenhaus Salzgitter.; Following the first international conference in 1999, twice as many new antiretroviral substances are in the early clinical or preclinical phase of investigation as are currently approved for ART in Germany . These data are almost certainly not complete, and the number of candidat
[Campaign against a chameleon. Therapeutic strategies to control a survival artist]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:80-1. Unique Identifier : AIDSLINE MED/20321541
[Observing CD4 cell count and viral load alone is not enough. Value of protease inhibitors]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:81-2. Unique Identifier : AIDSLINE MED/20321542
[Therapy planning. It depends on the proper administration series]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:82-5. Unique Identifier : AIDSLINE MED/20321543
[Therapy of advanced stages. "Mega-HAART" or "drug holiday"?]: MMW Fortschr Med. 2000 Mar 13;142 Suppl 1:86-7. Unique Identifier : AIDSLINE MED/20321544
Good worms or bad worms: do worm infections affect the epidemiological patterns of other diseases? [see comments]: Parasitol Today. 2000 Jul;16(7):273-4. Unique Identifier : AIDSLINE MED/20317281; Bundy D; Sher A; Michael E; World Bank, 1818 H Street NW, Washington DC 20433, USA.; dbundy@worldbank.org
Good worms or bad worms: do worm infections affect the epidemiological patterns of other diseases? [letter; comment]: Parasitol Today. 2000 Jul;16(7):312. Unique Identifier : AIDSLINE MED/20317290; Bentwich Z
Justice and access to therapies for AIDS.: AIDS Public Policy J. 1999 Spring;14(1):20-5. Unique Identifier : AIDSLINE MED/20370100; Eckenwiler L; Department of Philosophy, Old Dominion University, Norfolk,; Virginia, USA.
Morals, methods, and neutrality in human-subject research.: AIDS Public Policy J. 1999 Spring;14(1):26-9. Unique Identifier : AIDSLINE MED/20370101; Herrera CD; Department of Philosophy and Religion, Montclair State; University, Upper Montclair, New Jersey, USA.
Organizational imperatives and policy perspectives of AIDS community-based organizations: a view from the states.: AIDS Public Policy J. 1999 Spring;14(1):3-19. Unique Identifier : AIDSLINE MED/20370099; Robins L; Backstrom C; Roosevelt University, Chicago, USA.
Toward a systematic understanding: a two-way relational model between drug use and HIV/AIDS.: AIDS Public Policy J. 1999 Spring;14(1):30-43. Unique Identifier : AIDSLINE MED/20370102; Shaw VN; Department of Sociology, California State University, Northridge,; USA.
Perspectives in conflict: the response to transfusion-associated AIDS.: AIDS Public Policy J. 1999 Summer;14(2):47-67. Unique Identifier : AIDSLINE MED/20370103; Corless IB; Stowell CP; Fulton R; Weeks OD; Massachusetts General Hospital Institute of Health Professions,; Boston, USA.
Examining medical coverage for Medicare beneficiaries with HIV/AIDS.: AIDS Public Policy J. 1999 Summer;14(2):68-79. Unique Identifier : AIDSLINE MED/20370104; Schietinger H; Schechter C; Domestic Health Services, Academy for Educational Development,; Washington, D.C., USA.
Military HIV-prevention education: the use of evaluation to inform the evolution of policy.: AIDS Public Policy J. 1999 Summer;14(2):80-91. Unique Identifier : AIDSLINE MED/20370105; Hendrix CW; Daniell FD; Johns Hopkins University School of Medicine, Baltimore, Maryland,; USA.
Human glomerular epithelial cell express CD4 and interaction with gp120 protein promotes PYK2 tyrosine phosphorylation.: Mol Cell Biol Res Commun. 1999 May;1(2):140-3. Unique Identifier : AIDSLINE MED/20391253; Kapasi AA; Franki N; Ding G; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York 11040, USA.; Focal segmental glomerulosclerosis (FSGS) is the predominant glomerular lesion in patients with HIV infection. Visceral glomerular epithelial cell (vGEC) injury is a key feature of this glomerular lesion. However, the exact mechanism of HIV-1-induced vGEC injury is not clear. We studied the presence of CD4 (HIV-1 rece
Management of the infant born to an HIV-1 infected mother.: Paediatr Drugs. 1999 Oct-Dec;1(4):325-30. Unique Identifier : AIDSLINE MED/20388473; Rongkavilit C; Mitchell CD; Nachman S; Division of Pediatric Infectious Diseases, University of Miami; School of Medicine, Florida, USA.
Pneumocystis carinii pneumonia in adolescents.: Paediatr Drugs. 2000 Mar-Apr;2(2):133-8. Unique Identifier : AIDSLINE MED/20391185; Rudy BJ; Rutstein RM; Nachman SA; Division of General Paediatrics, Children's Hospital of; Philadelphia, USA.
[Transmission of HBV, HCV and HIV by infectious medical personnel--presentation of an overview]: Chirurg. 2000 Apr;71(4):389-95. Unique Identifier : AIDSLINE MED/20299644; Hasselhorn HM; Hofmann F; Lehrstuhl fur Arbeitsphysiologie, Arbeitsmedizin und; Infektionsschutz, Bergische Universitat/Gesamthochschule,; Wuppertal. hans-martin.hasselhorn@arbmed.uni-wuppertal.de; This report analyzes 46 cases of personnel-to-patient transmissions of hepatitis B (HB), hepatitis C (HC) and HIV in health care settings. Similar circumstances were found for transmission of HB (40 cases, 404 infected patients), HC (4 cases, 224 infected patients) and HIV (2 cases, 7 infected patients). Cases with th
[European and North American regulations on employing HBV-, HCV- and HIV-infected persons in health care]: Chirurg. 2000 Apr;71(4):396-403. Unique Identifier : AIDSLINE MED/20299645; Hofmann F; Hasselhorn HM; Lehrstuhl fur Arbeitsphysiologie, Arbeitsmedizin und; Infektionsschutz, Bergische Universitat-Gesamthochschule; Wuppertal.; In the United States of America (1991), in Canada (1998), in the UK (1993, 1994) and in Germany (1999) recommendations have been published concerning performance of exposure-prone procedures (EPP) by persons i
A video densitometric analysis of viral burden and follicular dendritic cell damage in lymph nodes in the latency phase of HIV infection.: Unique Identifier : AIDSLINE MED/20341015 P; Zannini C; Favre A; Ciccone E; Plebani A; Duse M; Grossi CE; Pesce C
Flow cytometric analysis of the Vbeta repertoire in healthy controls.: Cytometry. 2000 Aug 1;40(4):336-45. Unique Identifier : AIDSLINE MED/20378902; van den Beemd R; Boor PP; van Lochem EG; Hop WC; Langerak AW; Wolvers-Tettero IL; Hooijkaas H; van Dongen JJ; Department of Immunology, Erasmus University Rotterdam/University; Hospital Rotterdam, The Netherlands.; BACKGROUND: Analysis of the T-cell receptor (TCR)-Vbeta repertoire has been used for studying selective T-cell responses in autoimmune disease, alloreactivity in transplantation, and protective immunity against microbial and tumor antigens. For the interpretation of these studies, we need information about the Vbeta r
Human amniotic membrane in the reconstruction of the ocular surface.: Doc Ophthalmol. 1999;98(3):273-83. Unique Identifier : AIDSLINE MED/20399544; Gabric N; Mravicic I; Dekaris I; Karaman Z; Mitrovic S; Lions Croatian Eye Bank, Department of Ophthalmology, Sveti Duh; General Hospital, Zagreb. lhob@yahoo.com; We sought to determine the efficacy of amniotic membrane transplantation (AMT) in the reconstruction of ocular surface. AMT was performed on 40 eyes with following indications: I, persistent corneal ulceration (n = 12); II, impending perforation (n = 6); III, persistent epithelial defect on the corneal graft (n = 6);
Hepatitis B and C virus infections and liver function in AIDS patients at Chris Hani Baragwanath Hospital, Johannesburg.: East Afr Med J. 2000 Jan;77(1):13-5. Unique Identifier : AIDSLINE MED/20401128; Lodenyo H; Schoub B; Ally R; Kairu S; Segal I; Centre for Clinical Research, Kenya Medical Research Institute,; South Africa.; BACKGROUND: Impaired liver function tests and co-infection with hepatitis viruses in AIDS patients are common in western countries. OBJECTIVE: To assess liver function and prevalence of co-infection with hepatitis B and hepatitis C viruses in AIDS patients at Chris Hani Baragwanath Hospital. DESIGN: A prospective stud
Factors affecting condom use among South African university students.: East Afr Med J. 2000 Jan;77(1):46-52. Unique Identifier : AIDSLINE MED/20401137; Peltzer K; Department of Psychology, University of the North, Sovenga, South; Africa.; OBJECTIVE: To investigate factors affecting condom use among South African university students. DESIGN: Cross-sectional survey. SETTING: Department of Psychology, University of the North, South Africa. PARTICIPANTS: One hundred and forty six female and sixty first year male psychology students, mean age 20.9 years (SD
Potential role of environmental factors in the etiology and pathogenesis of atopy: a working model.: Environ Health Perspect. 1999 Jun;107 Suppl 3:485-7. Unique Identifier : AIDSLINE MED/99353943; Holt PG; TVW Telethon Institute for Child Health Research, Perth, Western; Australia. patrick@ichr.uwa.edu.au; Sensitization to inhalant allergens commonly commences in utero, and most children are born with weak T helper-2 (Th2)-polarized T-cell immunity to these agents. During early life, these responses are normally deviated toward the Th1 cytokine profile. However, in atopics this immune deviation process fails, leading in
Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity.: Environ Health Perspect. 1999 Oct;107 Suppl 5:807-10. Unique Identifier : AIDSLINE MED/99434037; Bagenstose LM; Salgame P; Monestier M; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140, USA.; Experimental models of chemically induced autoimmunity have contributed to our understanding of the development of autoimmune diseases in humans. Heavy metals such as mercury induce a dramatic activation of the immune system and autoantibody production in genetically susceptible rats and mice. This autoimmune syndrome
Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women.: Unique Identifier : AIDSLINE MED/20387168; Yang JH; Chen CD; Wu MY; Chao KH; Yang YS; Ho HN; OBJECTIVE: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). DESIGN: Prospective study. SETTING: University teaching hospital. PATIENT(S): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). INTERVENTION(S):
Characterization of expanded T cell clones in healthy macaques: ontogeny, distribution and stability.: Dev Comp Immunol. 2000 Sep-Oct;24(6-7):703-15. Unique Identifier : AIDSLINE MED/20293001; Nam KH; Illes Z; Terao K; Yoshikawa Y; Yamamura T; Tsukuba Primate Center, National Institute of Infectious; Diseases, Ibaraki, Japan.; Peripheral expanded T cell clones have been discussed mainly in relation to certain diseases or immune function in humans and mice. There is little information on their ontogeny, stability and distribution among T cell subsets as well as major lymphoid organs. We applied reverse transcription-polymerase chain reaction
Lentivirus vectors for gene therapy.: Biochem Soc Trans. 1999 Dec;27(6):841-7. Unique Identifier : AIDSLINE MED/20288923; Lever AM; Kaye JF; McCann E; Chadwick D; Dorman N; Thomas J; Zhao J; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, U.K.
All that scallops is not celiac disease.: Gastrointest Endosc. 2000 Jun;51(6):717-20. Unique Identifier : AIDSLINE MED/20300719; Shah VH; Rotterdam H; Kotler DP; Fasano A; Green PH; Department of Surgical Pathology, Columbia University College of; Physicians and Surgeons, New York, NY 10032, USA.; BACKGROUND: Scalloping of duodenal folds as well as a mosaic mucosal pattern, decreased folds, and increased vascularity are markers of duodenal mucosal injury, the most common cause being celiac disease. We have recognized scalloping in patients with a variety of conditions other than celiac disease. METHODS: Clinica
Phase II study of 3-hour infusion of high dose paclitaxel in refractory and relapsed aggressive non-Hodgkin's lymphomas. Groupe d'Etude des Lymphomes de l'Adulte.: Haematologica. 2000 May;85(5):502-7. Unique Identifier : AIDSLINE MED/20261487; Casasnovas RO; Haioun C; Dumontet C; Gabarre J; Richard B; Lederlin P; Caillot D; Stamatoullas A; Morel P; Quesnel B; Blay JY; Bouabdallah K; Gisselbrecht C; Hematologie Clinique, Hopital Le Bocage CHU Dijon, 2104 Dijon; Cedex, France. hemato.clinique@planetb.fr; BACKGROUND AND OBJECTIVE: The first clinical studies of paclitaxel as a single agent for the treatment of relapsed or refractory low or intermediate grade non-Hodgkin s lymphomas (NHL) yielded controversial results regarding the response rates observed, mainly related to the dose and schedule of administration used. T
Influence of sample storage time and temperature on lymphocyte subset counts using a FACScount system [letter]: Haematologica. 2000 May;85(5):550-1. Unique Identifier : AIDSLINE MED/20261497; Ruiz AR; Fernandez IP; Perea Baena JM; de La Torre FJ; Ramirez GR
[Risk of transmission of viral disease by needle punctures and cuts in hospital health care workers]: Harefuah. 1998 Nov 1;135(9):337-9, 408. Unique Identifier : AIDSLINE MED/20369092; Mishal Y; Yosefy C; Hay E; Catz D; Ambon E; Schneider R; Emergency Dept., Barzilai Medical Center, Ashkelon.; The accidental exposure of the health care workers (HCW) to blood and blood products constitutes a danger for transmission of blood-borne pathogens and the development of severe diseases. Most attention is focused on exposure to the viruses of hepatitis B, C and human immunodeficiency. The objectives of this prospectio
Antigen dose defines T helper 1 and T helper 2 responses in the lungs of C57BL/6 and BALB/c mice independently of splenic responses.: Immunol Lett. 2000 May 1;72(2):119-26. Unique Identifier : AIDSLINE MED/20302673; Morokata T; Ishikawa J; Yamada T; Inflammation Research Pharmacology Laboratories, Institute for; Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21; Miyukigaoka, Tsukuba-shi, 305-8585, Ibaraki, Japan.; morokata@yamanouchi.co.jp; To investigate the effect of antigen dose on immune response, C57BL/6 and BALB/c mice were sensitized with aluminum hydroxide gel (alum)-precipitated ovalbumin (OVA) then challenged with aerosolized OVA. Low-dose sensitization (less than 8 &mgr;g of OVA) elicited T helper 2 (Th2)-type immunoglobulins (Igs) secretio
Strong alpha beta and gamma delta TCR response in a patient with disseminated Mycobacterium avium infection and lack of NK cells and monocytopenia.: Immunol Lett. 2000 May 1;72(2):75-82. Unique Identifier : AIDSLINE MED/20302667; Wendland T; Herren S; Yawalkar N; Cerny A; Pichler WJ; Clinic for Rheumatology and Clinical Immunology/Allergology,; University Hospital Bern, Freiburgstrasse, CH-3010, Bern,; Switzerland.; Infection with atypical mycobacteria occurs mainly in patients with a compromised cellular immune system, in particular in those with a defective T cell or monocyte function. Here we analyzed the specific immune response of an adolescent HIV-negative patient with disseminated mycobacterium avium infection and fatal va
Role of chaperones in antigen processing.: Immunol Invest. 2000 May;29(2):101-4. Unique Identifier : AIDSLINE MED/20311236; Nicchitta CV; Department of Cell Biology, Duke University Medical Center,; Durham, North Carolina 27710, USA.
The role of CD40-CD154 interactions in the regulation of cell mediated immunity.: Immunol Invest. 2000 May;29(2):111-4. Unique Identifier : AIDSLINE MED/20311238; Miga A; Masters S; Gonzalez M; Noelle RJ; Department of Microbiology, Dartmouth Medical School, Lebanon, NH; 03756, USA.; CD40 is expressed on a diverse array of cell types from the hematopoietic and non-hematopoietic compartments. Within the hematopoietic compartment, CD40 is found constitutively expressed on B cells, dendritic cells (DC) and macrophages. The function of CD40 in B cells has been documented as being essential in the cont
Amplification of T cell-mediated immune responses by antibody-cytokine fusion proteins.: Immunol Invest. 2000 May;29(2):117-20. Unique Identifier : AIDSLINE MED/20311239; Lode HN; Xiang R; Gillies SD; Reisfeld RA; Department of Immunology, The Scripps Research Institute, La; Jolla, CA 92037, USA.
Approaches for immunotherapy of lymphomas.: Immunol Invest. 2000 May;29(2):93-5. Unique Identifier : AIDSLINE MED/20311234; Kwak LW; National Cancer Institute, Division of Clinical Sciences,; Bethesda, MD, USA.
Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.: Immunol Invest. 2000 May;29(2):97-100. Unique Identifier : AIDSLINE MED/20311235; Tortorella D; Gewurz B; Schust D; Furman M; Ploegh H; Harvard Medical School, Department of Pathology, Boston,; Massachusetts 02115, USA.
Suppression of experimental autoimmune tubulointerstitial nephritis in BALB/c mice by berberine.: Unique Identifier : AIDSLINE MED/20283569 P
The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation.: J Biol Chem. 2000 Jul 28;275(30):23097-105. Unique Identifier : AIDSLINE MED/20390066; Cohen GB; Rangan VS; Chen BK; Smith S; Baltimore D; AIDS Research Center, Massachusetts General Hospital, Harvard; Medical School, Charlestown, Massachusetts 02129, USA.; A HIV-1 Nef affinity column was used to purify a 35-kDa Nef-interacting protein from T-cell lysates. The 35-kDa protein was identified by peptide microsequence analysis as the human thioesterase II (hTE) enzyme, an enzyme previously identified in a yeast two-hybrid screen as a potential Nef-interacting protein. Immuno
The major head protein of bacteriophage T4 binds specifically to elongation factor Tu.: J Biol Chem. 2000 Jul 28;275(30):23219-26. Unique Identifier : AIDSLINE MED/20390084; Bingham R; Ekunwe SI; Falk S; Snyder L; Kleanthous C; School of Biological Sciences, University of East Anglia, Norwich; NR4 7TJ, United Kingdom.; The Lit protease in Escherichia coli K-12 strains induces cell death in response to bacteriophage T4 infection by cleaving translation elongation factor (EF) Tu and shutting down translation. Suicide of the cell is timed to the appearance late in the maturation of the phage of a short peptide sequence in the major hea
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease.: J Clin Endocrinol Metab. 2000 Aug;85(8):2775-8. Unique Identifier : AIDSLINE MED/20401704; Yamada T; Sato A; Komiya I; Nishimori T; Ito Y; Terao A; Eto S; Tanaka Y; Department of Medicine, Kashiwa City Hospital, Chiba, Japan.; In hyperthyroid Graves disease, short-term methimazole is sufficient to induce lasting remission in some patients, but even long-term treatment fails to do so in others. We have evaluated the role of autoimmune abnormalities in the helper T cell type 2 (TH2)-interleukin-13 (IL-13)-TSH receptor system in maintaining h
Il-4 and IFN-gamma mRNA induction in human peripheral lymphocytes specific for beta-lactam antibiotics in immediate or delayed hypersensitivity reactions.: J Clin Immunol. 2000 Mar;20(2):107-16. Unique Identifier : AIDSLINE MED/20279482; Gaspard I; Guinnepain MT; Laurent J; Bachot N; Kerdine S; Bertoglio J; Pallardy M; Lebrec H; INSERM U461, Faculte de Pharmacie, Chatenay-Malabry, France.; Beta-lactam antibiotics elicit CD4+ and CD8+ T-cell-mediated immune responses that play a central role in allergic reactions. However, the involvement of a type 1- (Th1 or Tc1) or a type 2-like (Th2 or Tc2) differentiation in drug allergy remains unclear. We investigated the expression of interleukin 4 (IL-4) and inte
Elevated plasma levels of 90K (Mac-2 BP) immunostimulatory glycoprotein in HIV-1-infected children.: J Clin Immunol. 2000 Mar;20(2):117-22. Unique Identifier : AIDSLINE MED/20279483; Groschel B; Braner JJ; Funk M; Linde R; Doerr HW; Cinatl J Jr; Iacobelli S; Institute of Medical Virology, Johann Wolfgang Goethe University,; Frankfurt/M., Germany.; 90K is a secreted serum glycoprotein with immune stimulatory activity. In this study, 90K plasma levels were determined by an enzyme-linked immunosorbent assay in 18 HIV-1-infected children and 10 uninfected control children. 90K levels in HIV-1-infected children (median, 12.5 microg/ml) were higher than in HIV-1 unin
Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene.: J Neuroimmunol. 2000 Aug 1;108(1-2):112-21. Unique Identifier : AIDSLINE MED/20361884; Koustova E; Sei Y; McCarty T; Espey MG; Ming R; Morse HC 3rd; Basile AS; Laboratory of Bioorganic Chemistry, Building 8, Room 1A15, MSC; 0826, NIDDK, NIH, Bethesda, MD 20892, USA.; Mice homozygous for a germline deletion of the interferon-gamma gene (IFN-gamma (-/-)) were infected with the LP-BM5 (BM5) retrovirus mixture to determine if the inability to produce IFN-gamma reduces collateral CNS damage associated with chronic neuroinflammation. Virus burdens in spleens and brains of infected mice
The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents.: BOLISM J Neuroimmunol. 2000 Aug 1;108(1-2):136-46. Unique Identifier : AIDSLINE MED/20361887; Dinter H; Tse J; Halks-Miller M; Asarnow D; Onuffer J; Faulds D; Mitrovic B; Kirsch G; Laurent H; Esperling P; Seidelmann D; Ottow E; Schneider H; Tuohy VK; Wachtel H; Perez HD; Department of Immunology, Berlex Biosciences, 15049 San Pablo; Ave., Richmond, CA 94804, USA. Harold_Dinter@Berlex.com; (range: 1.4% in London and 52.6% in Madrid).A
Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients.: J Neuroimmunol. 2000 Aug 1;108(1-2):201-6. Unique Identifier : AIDSLINE MED/20361894; Qin Y; Zhang DQ; Prat A; Pouly S; Antel J; Neuroimmunology Unit, Montreal Neurological Institute, McGill; University, 3801 University Street, Quebec, H3A 2B4, Montreal,; Canada.; We analyzed the effects of glatiramer acetate (GA) therapy on in vitro proliferative responses and cytokine production by lymphocytes derived from multiple sclerosis patients receiving this therapy. We confirmed that lymphocytes derived from GA naive patients show a high frequency of response when initially exposed to
Evidence of cerebrospinal fluid free kappa light chains in AIDS patients with Toxoplasma gondii encephalitis.: J Neuroimmunol. 2000 Aug 1;108(1-2):221-6. Unique Identifier : AIDSLINE MED/20361897; Contini C; Fainardi E; Cultrera R; Seraceni S; Castellazzi M; Peyron F; Granieri E; Section of Infectious Diseases, Department of Clinical and; Experimental Medicine, Via Fossato di Mortara 23, University of; Ferrara, I-44100, Ferrara, Italy. cnc@ifeuniv.unife.it; Cerebrospinal fluid (CSF) free light chains of kappa or lambda (FLC kappa/lambda) type were investigated by affinity mediated blotting technique (AMI) and ELISA in 28 patients of which nine with AIDS and Toxoplasma gondii encephalitis (AIDS, TE), 11 with AIDS with or without other CNS AIDS-related opportunistic infect
T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis.: J Neuroimmunol. 2000 Aug 1;108(1-2):29-39. Unique Identifier : AIDSLINE MED/20361874; Wang ZY; Diethelm-Okita B; Okita DK; Kaminski HJ; Howard JF; Conti-Fine BM; Department of Biochemistry, Molecular Biology and Biophysics,; University of Minnesota, Twin Cities Campus, Minnesota MN 55108,; USA.; We examined the proliferative response of blood CD4(+) cells to muscle acetylcholine receptor (AChR) subunits and the epitope repertoire of the epsilon and gamma subunits, in ocular myasthenia gravis (oMG) patients and healthy subjects. oMG patients seldom recognized all subunits. The frequency and intensity of recogn
A plasmid construct encoding murine interferon beta antagonizes the replication of herpes simplex virus type I in vitro and in vivo.: J Neuroimmunol. 2000 Aug 1;108(1-2):92-102. Unique Identifier : AIDSLINE MED/20361882; Cui B; Carr DJ; Department of Microbiology, Immunology, and Parasitology,; Louisiana State University Health Sciences Center, New Orleans,; LA, USA.; In the present study, we employed a plasmid DNA encoding murine interferon (IFN)-beta to assess its antiviral efficacy in an in vitro transfection-infection assay and in an ocular HSV-1 infection model of mice. In the in vitro assay, transfection of mouse fibroblasts with the IFN-beta transgene resulted in a 17-fold o
Molecular techniques for clinical diagnostic virology.: J Clin Pathol. 2000 Jul;53(7):502-6. Unique Identifier : AIDSLINE MED/20416856; Read SJ; Burnett D; Fink CG; Micropathology Ltd, University of Warwick Science Park, Barclays; Venture Centre, Coventry, UK. micropathology@telinco.co.uk
Impact of a multi-method promotional package on awareness and knowledge about STD and AIDS among the trainees of an industrial training institute in a resettlement colony of Delhi, India.: J Commun Dis. 1999 Dec;31(4):209-16. Unique Identifier : AIDSLINE MED/20392987; Chaturvedi S; Gupta P; Rajoura OP; Kumar P; Aggarwal OP; University College of Medical Sciences, Delhi, India.; To design and apply a multi-method promotional package for enhancing awareness and knowledge on STD and AIDS among ITI trainees, and evaluate its impact, an intervention study, using pre and post assessment of the subjects for comparison was carried out. The study was carried out in the Industrial Training Institute (
AIDS-related apprehensions among nursing students of Delhi.: J Commun Dis. 1999 Dec;31(4):217-21. Unique Identifier : AIDSLINE MED/20392988; Kumar A; Lal P; Ingle GK; Gulati N; National Institute of Communicable Disease, Sham Nath Marg,; Delhi.; Students from a nursing school of Delhi were surveyed anonymously using a self-administered questionnaire to explore various AIDS-related apprehensions and their possible reasons. The observations revealed that, majority of the students and their families/friends feared that these students were at risk of contracting
Incidence of HTLV-I in high-risk population in Delhi.: J Commun Dis. 1999 Dec;31(4):237-40. Unique Identifier : AIDSLINE MED/20392991; Varma M; Mehta G; Patel Chest Institute, University of Delhi.; Human infection due to HTLV-I occurs by transmission of infected T-cells via sexual intercourse, blood transfusion or breastfeeding. The present investigation was carried out to find the incidence of HTLV-I in high risk population and its relationship with syphilis and HIV infection. The study group comprised 124 ante
Current issues and update on human immunodeficiency virus infection in the orthopaedic setting.: Instr Course Lect. 2000;49:621-5. Unique Identifier : AIDSLINE MED/20288027; Panlilio AL; HIV Infections Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia, USA.; The risk of HIV transmission in the health care setting is a composite of risks, with exposure to blood being the most important source of infection and percutaneous injuries posing the greatest risk of transmission. The frequency of blood contact varies by occupation, procedure performed, and precautions used. Data s
Issues and update on HIV infection in orthopaedic surgery: risk of surgery on HIV-infected patients.: Instr Course Lect. 2000;49:627-9. Unique Identifier : AIDSLINE MED/20288028; Wiedel JD; Department of Orthopaedics, University of Colorado Health; Sciences Center, Denver, USA.
Poliovirus-specific intestinal antibody responses coincide with decline of poliovirus excretion.: J Infect Dis. 2000 Jul;182(1):1-5. Unique Identifier : AIDSLINE MED/20341724; Valtanen S; Roivainen M; Piirainen L; Stenvik M; Hovi T; Department of Biochemistry, National Public Health Institute,; Helsinki, Finland. sanna.valtanen@ktl.fi; Antibody responses to poliovirus type 3 were studied in fecal samples of 66 children immunized with 3 doses of enhanced-potency inactivated poliovirus vaccine (E-IPV), followed by 1 dose of monovalent oral poliovirus vaccine (OPV, type 3 Sabin). One fecal sample taken before OPV vaccination and 9 collected thereafter
Disease progression and early viral dynamics in human immunodeficiency virus-infected children exposed to zidovudine during prenatal and perinatal periods.: J Infect Dis. 2000 Jul;182(1):104-11. Unique Identifier : AIDSLINE MED/20341737; Kuhn L; Abrams EJ; Weedon J; Lambert G; Schoenbaum EE; Nesheim SR; Palumbo P; Vink PE; Bulterys M; Columbia University, Sergievsky Center, New York, NY 10032, USA.; lk24@columbia.edu; Zidovudine (Zdv) is widely used to reduce maternal-infant human immunodeficiency virus transmission (HIV), but its consequences for disease progression among children infected despite Zdv exposure remain unknown. In a multicenter observational cohort study of 325 HIV-infected children born during 1986-1997, clinical p
Selection of drug-resistant variants in the female genital tract of human immunodeficiency virus type 1-infected women receiving antiretroviral therapy.: J Infect Dis. 2000 Jul;182(1):112-22. Unique Identifier : AIDSLINE MED/20341738; Si-Mohamed A; Kazatchkine MD; Heard I; Goujon C; Prazuck T; Aymard G; Cessot G; Kuo YH; Bernard MC; Diquet B; Malkin JE; Gutmann L; Belec L; Laboratoire de Virologie, Hopital Broussais/Hopital Europeen; Georges Pompidou, Paris, France.; We investigated human immunodeficiency virus (HIV) type 1 RNA, proviral DNA, and antiretroviral drug-resistant variants in cervicovaginal secretions of HIV-1-infected women receiving antiretroviral therapy. The prevalence of detectable HIV-1 RNA in genital secretions was inversely related to the number of antiretrovir
Factors contributing to the lack of human immunodeficiency virus type 1 (HIV-1) transmission in HIV-1-discordant partners.: J Infect Dis. 2000 Jul;182(1):123-32. Unique Identifier : AIDSLINE MED/20341739; Bienzle D; MacDonald KS; Smaill FM; Kovacs C; Baqi M; Courssaris B; Luscher MA; Walmsley SL; Rosenthal KL; Department of Pathobiology, University of Guelph, Guelph,; Ontario, Canada. dbienzle@ovc.uoguelph.ca; Correlates of resistance to infection by human immunodeficiency virus type 1 (HIV-1) are important for defining potential therapeutic interventions and for prophylactic vaccination. In this study, 11 couples discordant in their HIV-1 infection status were prospectively evaluated for the presence of protective factors.
Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses.: J Infect Dis. 2000 Jul;182(1):180-90. Unique Identifier : AIDSLINE MED/20341746; Yamamoto M; Kiyono H; Kweon MN; Yamamoto S; Fujihashi K; Kurazono H; Imaoka K; Bluethmann H; Takahashi I; Takeda Y; Azuma M; McGhee JR; Department of Clinical Pathology, Nihon University School of; Dentistry at Matsudo, Chiba, Japan.; In an in vitro study, Escherichia coli heat-labile toxin (LT) was shown to directly affect activated CD4(+) T cells and support interleukin (IL)-5 production in IL-4-deficient (IL-4(-/-)) mice, whereas cholera toxin (CT) did not. Both LT and CT enhanced B7-2 expression on B cells and macrophages. These effects were no
Chronic schistosomiasis: dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness.: J Infect Dis. 2000 Jul;182(1):260-5. Unique Identifier : AIDSLINE MED/20341755; van Den Biggelaar AH; Grogan JL; Filie Y; Jordens R; Kremsner PG; Koning F; Yazdanbakhsh M; Department of Parasitology, Leiden University Medical Center,; 2300 RC Leiden, The Netherlands. A.H.J.van_den_Biggelar@LUMC.NL; Chronic infection with helminths is associated with down-regulated antigen-specific T cell responses. In order to determine whether schistosome-specific T cells are present, yet functionally unresponsive, or absent in the periphery of chronically infected persons, autologous granulocyte-macrophage colony-stimulating f
Evaluation of the latency-associated nuclear antigen (ORF73) of Kaposi's sarcoma-associated herpesvirus by peptide mapping and bacterially expressed recombinant western blot assay.: J Infect Dis. 2000 Jul;182(1):306-10. Unique Identifier : AIDSLINE MED/20341763; Olsen SJ; Sarid R; Chang Y; Moore PS; Division of Baterial and Mycotic Diseases, Centers for Disease; COntrol and Prevention, Atlanta, GA 30333, USA. sco2@cdc.gov; Kaposi s sarcoma (KS)-associated herpesvirus open-reading frame (ORF) 73 encodes a latency-associated nuclear antigen (LANA) that is the basis for several serologic assays. Immunoreactive epitopes were searched for by peptide mapping, and 171 cleavable, biotinylated 17-mer peptides offset by 5 residues were synthesize
Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection.: J Infect Dis. 2000 Jul;182(1):311-5. Unique Identifier : AIDSLINE MED/20341764; Brambilla A; Villa C; Rizzardi G; Veglia F; Ghezzi S; Lazzarin A; Cusini M; Muratori S; Santagostino E; Gringeri A; Louie LG; Sheppard HW; Poli G; Michael NL; Pantaleo G; Vicenzi E; AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute,; Milan, Italy.; The SDF-1 3 A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant associa
Analysis of env sequence evolution in human immunodeficiency virus-infected patients receiving therapy with nonnucleoside reverse-transcriptase inhibitors.: J Infect Dis. 2000 Jul;182(1):316-20. Unique Identifier : AIDSLINE MED/20341765; Dykes C; Mootsikapun P; Dexter A; Berrios L; Chiulli M; Reichman RC; Demeter LM; Infectious Diseases Unit, University of Rochester School of; Medicine and Dentistry, Rochester, NY 14642, USA.; Carrie_Dykes@urmc.rochester.edu; Nonnucleoside reverse-transcriptase inhibitors (NNRTIs) can rapidly select for drug-resistant human immunodeficiency virus type 1 (HIV-1) variants, although their effect on HIV-1 quasi-species diversity is unknown. To determine if changes in env gene diversification occur with NNRTI therapy, we used the heteroduplex t
In vivo antagonism with zidovudine plus stavudine combination therapy.: J Infect Dis. 2000 Jul;182(1):321-5. Unique Identifier : AIDSLINE MED/20341766; Havlir DV; Tierney C; Friedland GH; Pollard RB; Smeaton L; Sommadossi JP; Fox L; Kessler H; Fife KH; Richman DD; 1University of California, San Diego, 2San Diego VA Medical; Center, San Diego, California, USA. dhavlir@ucsd.edu; Human immunodeficiency virus (HIV)-infected subjects receiving zidovudine were randomized either to add stavudine ( d4T ) or didanosine (ddI) to their current regimen or to switch to dd
Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults.: J Infect Dis. 2000 Jul;182(1):326-9. Unique Identifier : AIDSLINE MED/20341767; Jacobson JM; Lowy I; Fletcher CV; O'Neill TJ; Tran DN; Ketas TJ; Trkola A; Klotman ME; Maddon PJ; Olson WC; Israel RJ; Mount Sinai Medical Center, New York, NY 10029-6574, USA.; jeffrey.jacobson@mssm.edu; PRO 542 (CD4-IgG2) is a recombinant antibody-like fusion protein wherein the Fv portions of both the heavy and light chains of human IgG2 have been replaced with the D1D2 domains of human CD4. Unlike monovalent and divalent CD4-based proteins, tetravalent PRO 542 potently neutralizes diverse primary human immunodefici
Prevalence of mutations associated with reduced antiretroviral drug susceptibility among human immunodeficiency virus type 1 seroconverters in the United States, 1993-1998.: J Infect Dis. 2000 Jul;182(1):330-3. Unique Identifier : AIDSLINE MED/20341768; Weinstock H; Respess R; Heneine W; Petropoulos CJ; Hellmann NS; Luo CC; Pau CP; Woods T; Gwinn M; Kaplan J; Centers for Disease Control and Prevention, Atlanta, GA 30333.; hsw2@cdc.gov; To assess the prevalence of mutations associated with decreased antiretroviral drug susceptibility, specimens were tested from persons infected with human immunodeficiency virus (HIV) during 1993-1998. Subjects were drug naive and were attending sexually transmitted disease clinics in 6 US cities. All were enrolled co
Incubation time of acute human immunodeficiency virus (HIV) infection and duration of acute HIV infection are independent prognostic factors of progression to AIDS.: J Infect Dis. 2000 Jul;182(1):334-7. Unique Identifier : AIDSLINE MED/20341769; Vanhems P; Hirschel B; Phillips AN; Cooper DA; Vizzard J; Brassard J; Perrin L; Laboratoire d'Epidemiologie et de Sante Publique, Universite; Claude Bernard Lyon 1, 8, av. Rockefeller, 69373 Lyon Cedex 08,; France. philipva@lyon-sud.univ-lyon1.fr; The severity and the duration of acute human immunodeficiency virus (HIV) infection (AHI) are associated with a faster rate of progression to AIDS, but the prognostic value of the length of incubation time of AHI (IncAHI), defined as the time between HIV infection and AHI, on progression to AIDS has not been assessed.
In vivo cytolysis and fusion of human immunodeficiency virus type 1-infected lymphocytes in lymphoid tissue.: J Infect Dis. 2000 Jul;182(1):338-42. Unique Identifier : AIDSLINE MED/20341770; Orenstein JM; Department of Pathology, George Washington University Medical; Center, Washington, DC 20037, USA. patjmo@gwumc.edu.; Lymphoid tissue was examined to see whether in vivo cytopathic effects of human immunodeficiency virus (HIV) infection on lymphocytes could be detected. Transmission electron microscopy of mechanical suspensions prepared from lymph nodes showed both replication and phagocytosis of HIV particles by macrophages. Phagoso
Sex and shedding of human immunodeficiency virus [letter; comment]: J Infect Dis. 2000 Jul;182(1):375-6. Unique Identifier : AIDSLINE MED/20341779; Cohen P
Detection of cytomegalovirus late (pp150) antigen in peripheral blood leukocytes of patients with human immunodeficiency virus-related lymphoma [letter; comment]: J Infect Dis. 2000 Jul;182(1):376-9. Unique Identifier : AIDSLINE MED/20341780; Gentile G; Capobianchi A; Gastaldi R; Rolli M; Capucci S; Girmenia C; Martino P
Possible mechanism for positive interaction of human T cell leukemia type I on liver disease in a hepatitis C virus-infected Japanese cohort [letter; comment]: J Infect Dis. 2000 Jul;182(1):379-80. Unique Identifier : AIDSLINE MED/20341783; Casseb J
Structural prerequisites for intersubtype B and D antigenicity of the third variable envelope region (V3) of human immunodeficiency virus type 1.: J Infect Dis. 2000 Jul;182(1):49-58. Unique Identifier : AIDSLINE MED/20341731; Lawoko A; Johansson B; Ljunggren J; Fries A; Fredriksson R; Georgievska L; Malmvall B; Pipkorn R; Fenyo EM; Blomberg J; Department of Medical Sciences, Section of Virology, Uppsala; Academic Hospital, S-751 85 Uppsala, Sweden.; To elucidate the structural requirements for intersubtype antigenicity of human immunodeficiency virus type 1 (HIV-1) third variable envelope region (V3), synthetic peptides were used in enzyme immunoassays (EIAs) with serum samples from persons with proven or probable subtype B and D infections. Mathematical analyses
Methods for investigation of the relationship between drug-susceptibility phenotype and human immunodeficiency virus type 1 genotype with applications to AIDS clinical trials group 333.: J Infect Dis. 2000 Jul;182(1):59-67. Unique Identifier : AIDSLINE MED/20341732; Sevin AD; DeGruttola V; Nijhuis M; Schapiro JM; Foulkes AS; Para MF; Boucher CA; Center for Biostatistics in AIDS Research, Harvard School of; Public Health, Boston, MA 02115-6018, USA.; asevin@sdac.harvard.edu; Use of human immunodeficiency virus (HIV) drug-resistance testing in therapeutic decision making may be aided by understanding the relationship between results of genotypic and drug-susceptibility phenotypic assays. We investigated this relationship by applying 3 different statistical methods-cluster analysis, recursi
Consistent and significant inhibition of human immunodeficiency virus type 1 envelope-mediated membrane fusion by beta-chemokines (RANTES) in primary human macrophages.: J Infect Dis. 2000 Jul;182(1):68-78. Unique Identifier : AIDSLINE MED/20341733; Stantchev TS; Broder CC; Department of Microbiology and Immunology, F. Edward Hebert; School of Medicine, Uniformed Services University of the Health; Sciences, Bethesda, MD 20814-4799, USA. tstanchev@mxb.usuhs.mil; Infection and entry of CD4(+) cells by human immunodeficiency virus type 1 (HIV-1) requires a coreceptor molecule, which, in concert with CD4, interacts with the viral envelope glycoprotein (Env), leading to membrane fusion. The principal coreceptors are the CCR5 and CXCR4 chemokine receptors. The suppressive effect o
Human immunodeficiency virus type 1 shedding pattern in semen correlates with the compartmentalization of viral Quasi species between blood and semen.: J Infect Dis. 2000 Jul;182(1):79-87. Unique Identifier : AIDSLINE MED/20341734; Gupta P; Leroux C; Patterson BK; Kingsley L; Rinaldo C; Ding M; Chen Y; Kulka K; Buchanan W; McKeon B; Montelaro R; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pittsburgh, PA; 15261, USA. pgupta1+@pitt.edu; High levels of human immunodeficiency virus (HIV) type 1 have been detected in semen at all stages of disease. However, it is not clear whether HIV-1 is shed in semen continuously or intermittently. In a prospective longitudinal study, viral RNA was measured weekly for 10 weeks in semen and blood of HIV-seropositive s
The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children.: J Infect Dis. 2000 Jul;182(1):88-95. Unique Identifier : AIDSLINE MED/20341735; Spiegel HM; Chandwani R; Sheehy ME; Dobroszycki J; Fennelly G; Wiznia A; Radding J; Rigaud M; Pollack H; Borkowsky W; Rosenberg M; Nixon DF; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, NY 10016, USA. hspiegel@adarc.org hspiegel@adarc.org; This cross-sectional study investigated the effect of early highly active antiretroviral therapy (HAART) on human immunodeficiency virus (HIV) type 1-specific CD8 T cell responses in children. HIV-1-specific CD8 T cell responses were quantified using an enzyme-linked immunospot assay to measure interferon-gamma-secret
Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected children.: J Infect Dis. 2000 Jul;182(1):96-103. Unique Identifier : AIDSLINE MED/20341736; Borkowsky W; Stanley K; Douglas SD; Lee S; Wiznia A; Pelton S; Yogev R; McIntosh K; Nachman S; Division of Infectious Diseases, New York University School of; Medicine, New York, NY 10016, USA. borkow01@mcgc16.med.nyu.edu; The response of 40 immunologic parameters was studied for 147 clinically stable, protease inhibitor-naive, human immunodeficiency virus (HIV)-infected children aged 2-17 years when antiretroviral therapy was changed to either a dual nucleoside analogue regimen or a protease inhibitor-containing regimen. Immunologic re
[HIV-1 (human immunodeficiency virus type 1) mutant strain associated with zidovudine resistance detected from a Japanese patient with primary HIV-1 infection]: Kansenshogaku Zasshi. 2000 Apr;74(4):360-4. Unique Identifier : AIDSLINE MED/20295549; Usuku S; Noguchi Y; Sakamoto M; Sagara H; Sudo K; Kondo M; Imai M; Yokohama City Institute of Health.; Sequences of HIV-1 pol gene were determined by direct sequencing from a Japanese patient with primary HIV-1 infection. The patient did not receive antiretroviral therapies. However we observed a HIV-1 mutant strain associated with zidovudine (ZDV) resistance. The patient had both the codon 70 and the codon 215 amino a
Innate and adaptive immunity in Candida albicans infections and saprophytism.: J Leukoc Biol. 2000 Aug;68(2):175-9. Unique Identifier : AIDSLINE MED/20401884; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy. lromani@unipg.it; Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of
Influence of type 2 T cell responses on the severity of encephalitis associated with influenza virus infection.: Unique Identifier : AIDSLINE MED/20401885; Kaji M; Kobayashi M; Pollard RB; Suzuki F; The role of type 2 T cell responses on the severity of post-infectious encephalitis was investigated in a mouse model of influenza virus infection. When mice were infected intracerebrally with 3.0 LD(50) of A/NWS33 strain of influenza virus, they all showed clinical signs of encephalitis, and 90% of
Predictive value of the ultrasensitive HIV viral load assay in clinical practice.: J Med Virol. 2000 Aug;61(4):411-6. Unique Identifier : AIDSLINE MED/20357694; Muir D; White D; King J; Verlander N; Pillay D; Public Health Laboratory and PHLS Antiviral Susceptibility; Reference Unit, Birmingham Heartlands Hospital and University of; Birmingham Medical School, United Kingdom.; The aim of this study was to determine whether an HIV viral load of
Accuracy of plasma HIV RNA quantification: a multicentre study of variability.: J Med Virol. 2000 Aug;61(4):417-22. Unique Identifier : AIDSLINE MED/20357695; Skidmore SJ; Zuckerman M; Parry JV; Public Health Laboratory, Heartlands Hospital, Birmingham, United; Kingdom.; Inaccurate quantification of plasma HIV RNA concentration may be detrimental to patient care, yet little is known about how reproducible results are within and between laboratories. Each week between January and April 1998 a different laboratory represented at the Public Health Laboratory Service HIV Diagnosis Forum s
Analysis of a human immunodeficiency virus type 1 gag mutant with an engineered 110-amino-acid insertion in the matrix protein domain.: J Med Virol. 2000 Aug;61(4):423-32. Unique Identifier : AIDSLINE MED/20357696; Wang CT; Yang AH; Chiang CC; Institute of Clinical Medicine, National Yang-Ming University; School of Medicine, Taiwan, Republic of China.; ctwang@vghtpe.gov.tw; A human immunodeficiency virus (HIV) matrix (MA) protein mutant was constructed by duplication of 107 codons of the HIV-1 MA domain. This MA protein duplication mutant (MAII) still could assemble and process particles, had a wild-type (wt) HIV particle density, and possessed reverse transcriptase activity of about 80%
Detection of TT virus DNA in patients with liver disease and recipients of liver transplant.: J Med Virol. 2000 Aug;61(4):455-61. Unique Identifier : AIDSLINE MED/20357700; Shang D; Lin YH; Rigopoulou I; Chen B; Alexander GJ; Allain JP; Department of Haematology, Division of Transfusion Medicine, East; Anglia Blood Centre, Cambridge, United Kingdom.; TT virus (TTV) is transfusion-transmissible but its involvement in post-transfusion hepatitis is uncertain. To investigate the potential association of TTV with liver diseases, the prevalence of TTV DNA was tested by semi-nested PCR in 113 carriers of hepatitis C virus (HCV), 10 patients with acute liver failure, 11 p
Human cytomegalovirus strains associated with congenital and perinatal infections.: J Med Virol. 2000 Aug;61(4):481-7. Unique Identifier : AIDSLINE MED/20357704; Trincado DE; Scott GM; White PA; Hunt C; Rasmussen L; Rawlinson WD; Virology Division, Department of Microbiology, South Eastern Area; Laboratory Services, The Prince of Wales Hospital, Randwick,; Australia.; The genotypes of human cytomegalovirus (HCMV) isolates from pediatric patients differs from those of infected adults in Australia . Genotypes were determined by PCR amplification of glycoprotein B (gB) sequences, with subsequent analysis by re
Detection of reverse transcriptase activity in the serum of patients with motor neurone disease.: J Med Virol. 2000 Aug;61(4):527-32. Unique Identifier : AIDSLINE MED/20357710; Andrews WD; Tuke PW; Al-Chalabi A; Gaudin P; Ijaz S; Parton MJ; Garson JA; Department of Virology, Royal Free and University College Medical; School, London, United Kingdom.; The recognition that both human and murine retroviruses can cause motor neurone disease-like syndromes has raised the possibility that a retrovirus may be involved in the aetiology of motor neurone disease. This possibility was explored by looking for evidence of reverse transcriptase in the serum of motor neurone dis
Nutritional factors and infectious disease contribute to anemia among pregnant women with human immunodeficiency virus in Tanzania.: J Nutr. 2000 Aug;130(8):1950-7. Unique Identifier : AIDSLINE MED/20377638; Antelman G; Msamanga GI; Spiegelman D; Urassa EJ; Narh R; Hunter DJ; Fawzi WW; Departments of Nutrition, Biostatistics and Epidemiology, Harvard; School of Public Health, Boston MA, 02115, USA.; The objective of this cross-sectional study was to identify risk factors for anemia among human immunodeficiency virus (HIV)-positive pregnant women in Dar es Salaam, Tanzania . Baseline data from 1064 women enrolled in a clinical trial on the effect of vitamin supplementation in
Coronary artery bypass grafting in a patient with human immunodeficiency virus: role of perioperative active anti-retroviral therapy.: Jpn Circ J. 1999 May;63(5):423-4. Unique Identifier : AIDSLINE MED/20397538; Imanaka K; Takamoto S; Kimura S; Morisawa Y; Ohtsuka T; Suematsu Y; Shirai T; Inoue K; Department of Cardiothroacic Surgery, University of Tokyo, Japan.; In a patient with severe ischemic heart disease and advanced human immunodeficiency virus (HIV) infection, vigorous perioperative treatment with anti-retroviral agents was given and coronary artery bypass surgery using cardiopulmonary bypass was successfully performed. This strategy could become the standard for patie
[Influence of a day care hospital on the incidence of hospital admission of AIDS patients]: Unique Identifier : AIDSLINE MED/20373501 P; Hernando A; Pulido F
Effect of thalidomide on gastrointestinal toxic effects of irinotecan [letter]: Lancet. 2000 Aug 12;356(9229):566-7. Unique Identifier : AIDSLINE MED/20405171; Govindarajan R; Heaton KM; Broadwater R; Zeitlin A; Lang NP; Hauer-Jensen M; Irinotecan is the only accepted second-line treatment for colorectal cancer in the USA. Doses are, however, frequently limited by associated late-onset diarrhoea. Thalidomide has antiangiogenic and immunomodulatory properties and is being investigated as an antineoplastic. We did a pilot study of
Primary prevention of HIV-1 [letter; comment]: Lancet. 2000 Aug 12;356(9229):600. Unique Identifier : AIDSLINE MED/20405202; Weisburger JH
Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group [see comments]: Medicine (Baltimore). 2000 Jul;79(4):250-60. Unique Identifier : AIDSLINE MED/20396949; Patterson TF; Kirkpatrick WR; White M; Hiemenz JW; Wingard JR; Dupont B; Rinaldi MG; Stevens DA; Graybill JR; Division of Infectious Diseases, University of Texas Health; Science Center, San Antonio 78284-7881, USA.; patterson@uthscsa.edu; A review of representative cases of invasive aspergillosis was conducted to describe current treatment practices and outcomes. Eighty-nine physicians experienced with aspergillosis completed case forms on 595 patients with proven or probable invasive aspergillosis diagnosed using modifications of the Mycoses Study Gro
Central nervous system aspergillosis in patients with human immunodeficiency virus infection. Report of 6 cases and review [see comments]: Medicine (Baltimore). 2000 Jul;79(4):269-80. Unique Identifier : AIDSLINE MED/20396951; Mylonakis E; Paliou M; Sax PE; Skolnik PR; Baron MJ; Rich JD; Infectious Disease Division, Massachusetts General Hospital,; Boston 02114-2696, USA. emylonakis@partners.org; Central nervous system (CNS) aspergillosis is a relatively uncommon complication of human immunodeficiency virus (HIV) infection. We describe 6 patients with the acquired immunodeficiency syndrome (AIDS) who developed CNS aspergillosis, and we review a total of 33 cases of CNS aspergillosis among HIV-infected individu
Immunological evaluation of human immunodeficiency virus infected individuals by flow cytometry.: Mem Inst Oswaldo Cruz. 2000 May-Jun;95(3):393-400. Unique Identifier : AIDSLINE MED/20261817; Neves I Jr; Morgado M; Laboratorio de Aids e Imunologia Molecular, Departamento de; Imunologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.; Human immunodeficiency virus (HIV) infection heavily compromises the immune system. The decrease of the T cell CD4+ subset along the evolution to acquired immunodeficiency syndrome has been considered as a hallmark of HIV infection. In this paper we review some aspects of the immunopathology of HIV infection and discu
Flow cytometry in the study of cell death.: Mem Inst Oswaldo Cruz. 2000 May-Jun;95(3):429-33. Unique Identifier : AIDSLINE MED/20261821; Bertho AL; Santiago MA; Coutinho SG; Laboratorio de Imunidade Celular e Humoral, Departamento de; Protozoologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.; bertho@fiocruz.br; In this report we present a concise review concerning the use of flow cytometric methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis. The applications of these techniques to clinical and basic research are also considered. The following cell features are use
Risk factors for tuberculosis among human immunodeficiency virus-infected persons. A case-control study in Belo Horizonte, Minas Gerais, Brazil (1985-1996).: Mem Inst Oswaldo Cruz. 2000 Jul-Aug;95(4):437-43. Unique Identifier : AIDSLINE MED/20366382; de Castro Toledo AC Jr; Greco DB; Antunes CM; Servico de Doencas Infecciosas e Parasitarias, Faculdade de; Medicina, Universidade Federal de Minas Gerais, Belo Horizonte,; MG, Brasil. toledoac@ig.com.br; The objective of this study was to identify tuberculosis risk factors and possible surrogate markers among human immunodeficiency virus (HIV)-infected persons. A retrospective case-control study was carried out at the HIV outpatient clinic of the Universidade Federal de Minas Gerais in Belo Horizonte. We reviewed the
Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.: Mol Cell Biol. 2000 Aug;20(16):5897-907. Unique Identifier : AIDSLINE MED/20372723; Fong YW; Zhou Q; Department of Molecular and Cell Biology, University of; California at Berkeley, Berkeley, California 94720-3206, USA.; Tat stimulation of human immunodeficiency virus type 1 (HIV-1) transcription requires Tat-dependent recruitment of human positive transcription elongation factor b (P-TEFb) to the HIV-1 promoter and the formation on the trans-acting response element (TAR) RNA of a P-TEFb-Tat-TAR ternary complex. We show here that the
Animal propagation and genomic survey of a genotype 1 isolate of Cryptosporidium parvum.: Mol Biochem Parasitol. 2000 May;108(2):187-97. Unique Identifier : AIDSLINE +; Widmer G; Akiyoshi D; Buckholt MA; Feng X; Rich SM; Deary KM; Bowman CA; Xu P; Wang Y; Wang X; Buck GA; Tzipori S; The Division of Infectious Diseases, Tufts University School of; Veterinary Medicine, 01536, North Grafton, MA, USA.; Human cryptosporidiosis is attributed to two major Cryptosporidium parvum genotypes of which type 1 appears to be the predominant. Most laboratory investigations however are performed using genotype 2 isolates, the only type which readily infects laboratory animals. So far type 1 has only been identified in humans and
[Prevalence of sexually transmitted diseases (STD) and HIV-infection among attendees of STD Outpatient Clinic, Dijkzigt University Hospital in Rotterdam; comparative analysis of years 1993 and 1998]: Ned Tijdschr Geneeskd. 2000 Jul 8;144(28):1351-5. Unique Identifier : AIDSLINE MED/20379446; van der Snoek EM; Chin-A-Lien RA; de Ridder MA; Willems PW; Verkooyen RP; van der Meijden WI; Academisch Ziekenhuis Rotterdam-Dijkzigt, afd.; Dermato-venerologie, Rotterdam.; OBJECTIVE: To gain an impression as to the possible trends in the prevalence of VD and HIV between 1993 and 1998. DESIGN: Retrospective. METHOD: Data of age, gender, ethnic background, sexual preference, intravenous drug use and a diagnosis of VD or HIV infection for persons attending the VD Outpatient Clinic of the D
A case of cerebral toxoplasmosis.: Neurol India. 2000 Jun;48(2):185-7. Unique Identifier : AIDSLINE MED/20342120; Alappat JP; Mathew CF; Jayakumar K; Suresh IC; Kumar S; Department of Neurosurgery, Medical College, Calicut, 673008,; India.; A histopathologically proven case of cerebral toxoplasmosis in a young HIV positive patient has been presented. The clinical problems in management are highlighted.
American Academy of Pediatrics. Committee on Infectious Diseases. Policy statement: recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine, and antibiotic prophylaxis.: Pediatrics. 2000 Aug;106(2 Pt 1):362-6. Unique Identifier : AIDSLINE MED/20381271; Heptavalent pneumococcal conjugate vaccine (PCV7) is recommended for universal use in children 23 months and younger, to be given concurrently with other recommended childhood vaccines at 2, 4, 6, and 12 to 15 months of age. For children 7 to 23 months old who have not received previous doses of PCV7, administration o
American Academy of Pediatrics. Committee on Infectious Diseases. Technical report: prevention of pneumococcal infections, including the use of pneumococcal conjugate and polysaccharide vaccines and antibiotic prophylaxis.: Pediatrics. 2000 Aug;106(2 Pt 1):367-76. Unique Identifier : AIDSLINE MED/20381272; Overturf GD; Pneumococcal infections are the most common invasive bacterial infections in children in the United States . The incidence of invasive pneumococcal infections peaks in children younger than 2 years, reaching rates of 228/100,000 in children 6 to 12 months old. Children with functional o
Detection of the 20-kDa virulence-associated antigen of Rhodococcus equi in malakoplakia-like lesion in pleural tissue obtained from an AIDS patient.: Pathol Res Pract. 2000;196(5):321-7; discussion 328. Unique Identifier : AIDSLINE MED/20292223; Caterino-de-Araujo A; de los Santos-Fortuna E; Zandona-Meleiro MC; Calore EE; Perez Calore NM; Immunology Department, Instituto Adolfo Lutz, Sao Paulo, SP,; Brazil. caterino@usp.br; A malakoplakia-like lesion was detected in a pleural biopsy from an AIDS patient presenting clinical and radiologic features of pneumonia. Cultures of bronchoalveolar lavage and pleural fluid evidenced Rhodococcus equi as the causative agent of pleuro-pulmonary infection. Immunochemical characterization of the R. equi
Recent HIV testing among general hospital inpatients with schizophrenia: findings from four New York City sites.: Psychiatr Q. 2000 Summer;71(2):177-93. Unique Identifier : AIDSLINE MED/20291622; Walkup J; McAlpine DD; Olfson M; Boyer C; Hansell S; Institute for Health, Health Care Policy, and Aging Research,; Rutgers University, New Brunswick, New Jersey 08901, USA.; walkup@rci.rutgers.edu, jaywalks@aol.com; BACKGROUND: While widely acknowledged to be an important clinical and public health issue, HIV assessment, counseling, and testing for the seriously mentally ill has not been well studied. OBJECTIVE: To determine what proportion and which inpatients with schizophrenia have been recently tested for HIV. METHOD: A sampl
Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography.: Radiographics. 2000 Jul-Aug;20(4):959-75; quiz 1108-9, 1112. Unique Identifier : AIDSLINE MED/20363880; Vitellas KM; Keogan MT; Freed KS; Enns RA; Spritzer CE; Baillie JM; Nelson RC; Department of Radiology, Ohio State University Medical Center,; Columbus, OH 43210, USA.; Magnetic resonance cholangiopancreatography (MRCP) is a relatively new, noninvasive cholangiographic technique that is comparable with invasive endoscopic retrograde cholangiopancreatography (ERCP) in the detection and characterization of extrahepatic bile duct abnormalities. The role of MRCP in evaluation of the intr
[Availability of voluntary prenatal HIV screening in primary health centers]: Rev Saude Publica. 1999 Dec;33(6):624-5. Unique Identifier : AIDSLINE MED/20156747; Neves FR; Passos AD; Gueleri WL; Programa de DST/Aids, Secretaria Municipal de Saude, Ribeirao; Preto, SP, Brasil.; A summary of the main steps towards the implementation of anti-HIV testing for pregnant women in the city is presented. Starting from August 1996, voluntary HIV testing became available to pregnant women seen at primary health centers in Ribeirao Preto, SP ( Brazil ), as part of the
P64k meningococcal protein as immunological carrier for weak immunogens.: Scand J Immunol. 2000 Aug;52(2):113-6. Unique Identifier : AIDSLINE MED/20389689; Gonzalez S; Alvarez A; Caballero E; Vina L; Guillen G; Silva R; Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Previously, the P64k meningococcal protein, an antigen of 64 kDa expressed in Escherichia coli, has been extensively characterized. We have successfully conjugated several synthetic peptides and meningococcal group C polysaccharide to P64k. In three out of four model peptides, the murine humoral immune response agains
T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation.: Scand J Immunol. 2000 Aug;52(2):123-30. Unique Identifier : AIDSLINE MED/20389691; Perola O; Ripatti A; Pelkonen J; Department of Clinical Microbiology, University of Kuopio,; Kuopio, Finland.; Owing to the contrasting observations in the field of interleukin(IL)-2 receptor research, the expression of IL-2 receptor chains was analysed on resting and anti-CD3 antibody (OKT3) activated CD4 and CD8 T cells by flow cytometry. Prior to the stimulation, 49% of CD4+
A soluble mannose receptor immunoadhesin enhances phagocytosis of Pneumocystis carinii by human polymorphonuclear leukocytes in vitro.: Scand J Immunol. 2000 Aug;52(2):131-7. Unique Identifier : AIDSLINE MED/20389692; Stehle SE; Rogers RA; Harmsen AG; Ezekowitz RA; Laboratory of Developmental Immunology, MassGeneral Hospital for; Children, and Harvard Medical School, Boston, Massachusetts; 02114, USA.; Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised hosts. In the normal host, P. carinii is susceptible to an array of first line host defense mechanisms that are operative in the lung. Alveolar macrophages play a central role in the clearance of inhaled organisms. The macroph
Expression of Fc(gamma)r1 (CD64) on polymorphonuclear leucocytes during progression to acquired immunodeficiency syndrome in perinatally human immunodeficiency virus-infected children.: Scand J Immunol. 2000 Aug;52(2):184-9. Unique Identifier : AIDSLINE MED/20389698; Moallem HJ; Kalayci O; Homel P; Fikrig S; Chice S; Durkin H; Michl J; Department of Pediatrics, State University of New York, Health; Science Center at Brooklyn, NY 11203, USA.; CD64, the high-affinity receptor in the family of FCgamma receptors, is not expressed constitutively in polymorphonuclear leucocytes (PMN). CD64 is expressed by PMNs in the late stages of human immunodeficiency virus (HIV) infection in adults. We followed the expression of CD64 on PMNs in perinatally HIV-infected chil
Effects of G-CSF on telomere lengths in PBMCs from human immunodeficiency virus-infected patients: results from a randomized, placebo-controlled trial.: Scand J Immunol. 2000 Aug;52(2):212-6. Unique Identifier : AIDSLINE MED/20389702; Aladdin H; Ullum H; Schjerling P; Skov Jensen M; Dam Nielsen S; Mathiesen L; Gerstoft J; Skinhoj P; Klarlund Pedersen B; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark. infdisha@rh.dk; Telomeres are unique terminal chromosomal structures, the length of which has been shown to decrease with cell division in vitro and with increased age in vivo for human somatic cells. In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is primarily found in CD8+ T cells, and not in CD4+ T c
Search for the origin of HIV and AIDS [letter; comment]: Science. 2000 Aug 18;289(5482):1140-1. Unique Identifier : AIDSLINE MED/20410275; Hooper E
Lay constructions of HIV and complementary therapy use.: Soc Sci Med. 2000 Jul;51(2):251-64. Unique Identifier : AIDSLINE MED/20290169; Pawluch D; Cain R; Gillett J; Department of Sociology, McMaster University, Hamilton, Ontario,; Canada. pawluch@mcmaster.ca; This study examines the meanings that individuals with HIV attach to their use of complementary therapies. A qualitative analysis of 66 interviews completed between 1993 and 1998 showed that complementary therapies represent different things for these individuals--a health maintenance strategy, a healing strategy, an
HIV/AIDS debate--time for a truce [editorial]: S Afr Med J. 2000 May;90(5):433. Unique Identifier : AIDSLINE MED/20360257; Ncayiyana DJ
HIV-positive test results [letter; comment]: S Afr Med J. 2000 May;90(5):449-50. Unique Identifier : AIDSLINE MED/20360261; Mankazana M
HIV surveillance results--little grounds for optimism yet.: S Afr Med J. 2000 May;90(5):452-3. Unique Identifier : AIDSLINE MED/20360264; Dorrington R; Bradshaw D; Bourne D; Karim SA
AIDS management options for SA [news]: S Afr Med J. 2000 May;90(5):461-3. Unique Identifier : AIDSLINE MED/20360269; Mbewu A; Matchaba P; Reddy S; Onyebujoh P
Mounting pressure on AIDS drug manufactures [news]: S Afr Med J. 2000 May;90(5):465. Unique Identifier : AIDSLINE MED/20360270
HIV infection, tuberculosis and non-tuberculous mycobacteria.: S Afr Med J. 2000 May;90(5):472-6. Unique Identifier : AIDSLINE MED/20360271; Churchyard GJ; Grant AD; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, UK.
Should the condom come with a health warning?: S Afr Med J. 2000 May;90(5):478-9. Unique Identifier : AIDSLINE MED/20360272; White G
IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis.: Surgery. 2000 Aug;128(2):133-8. Unique Identifier : AIDSLINE MED/20382820; Song GY; Chung CS; Chaudry IH; Ayala A; Center for Surgical Research and Department of Surgery, Brown; University School of Medicine and Rhode Island Hospital,; Providence, 02903, USA.; BACKGROUND: Although studies have shown that there is a marked depression in cell-mediated (T(H)(1)) immunity after the onset of sepsis, the mechanism by which this occurs remains unknown. In this regard, the T(H2) cytokine IL-4 is known to regulate T(H1) and T(H2) cell responsiveness primarily through the activation
A central role for CD95 (Fas) in T-cell reactivity after injury.: Surgery. 2000 Aug;128(2):159-64. Unique Identifier : AIDSLINE MED/20382824; Kell MR; Shelley O; Mannick JA; Guo Z; Lederer JA; Department of Surgery(Immunology), Brigham and Women's Hospital; and Harvard Medical School, Boston, MA 02115, USA.; BACKGROUND: Recent findings indicate that severe injury primes the immune system for an enhanced and lethal proinflammatory cytokine response against bacterial-derived superantigens. This study asked whether this response to injury involves the CD95 (Fas) signaling pathway. METHODS: To assess superantigen-mediated mor
Intrathymic alloantigen-mediated, tolerant, completely major histocompatibility complex-mismatched mouse hearts are specifically rejected by adoptively transferred anti-class I L(d+)-specific 2C cells.: Surgery. 2000 Aug;128(2):206-12. Unique Identifier : AIDSLINE MED/20382831; Otomo N; Motoyama K; Yu S; Shimizu Y; Margenthaler J; Tu F; Flye MW; Department of Surgery, Washington University School of Medicine,; St Louis, MO 63110, USA.; BACKGROUND: Tolerance to cardiac allografts can be induced in mice and rats by the injection of donor alloantigen into the thymus in combination with a CD4 T-cell-depleting antibody. CD8(+) cells in these animals are hyporesponsive to graft-specific alloantigens. Most of the CD8(+) T cells in the transgenic 2C mouse e
Mitral annular dynamics during rapid atrial pacing.: Surgery. 2000 Aug;128(2):361-7. Unique Identifier : AIDSLINE MED/20382855; Timek TA; Lai DT; Dagum P; Green GR; Glasson JR; Daughters GT; Ingels NB Jr; Miller DC; Department of Cardiovascular and Thoracic Surgery, Stanford; University School of Medicine, CA 94305-5247, USA.; INTRODUCTION: Ovine mitral annular area (MAA) reduction predominantly occurs before ventricular systole. We used the myocardial marker methods to investigate left atrial and MAA dynamics during rapid atrial pacing. METHODS: Seven sheep underwent implantation of 21 myocardial markers around the mitral annulus, the left
Nutritional status influences plasma fibrinogen concentration: evidence from the THUSA survey.: Thromb Res. 2000 Jun 1;98(5):383-94. Unique Identifier : AIDSLINE MED/20291372; James S; Vorster HH; Venter CS; Kruger HS; Nell TA; Veldman FJ; Ubbink JB; Department of Biological Sciences, University of North-West,; Mmabatho, South Africa.; Nutritional status and risk factors for chronic diseases, including plasma fibrinogen and its determinants, of Africans in the Northwest Province of South Africa , have been studied in a cross-sectional survey. A representative sample of 1854 apparently healthy African men and wo
Photochemical inactivation of bacteria and HIV in buffy-coat-derived platelet concentrates under conditions that preserve in vitro platelet function.: Vox Sang. 2000;78(4):209-16. Unique Identifier : AIDSLINE MED/20355219; Knutson F; Alfonso R; Dupuis K; Mayaudon V; Lin L; Corash L; Hogman CF; Department of Clinical Immunology and Transfusion Medicine,; University Hospital, Uppsala, Sweden. Folke.Knutson@KlinImm.uu.se; BACKGROUND AND OBJECTIVES: A photochemical process has been tested for the inactivation of viruses and bacteria in buffy-coat derived platelet concentrates (BC PCs). MATERIALS AND METHODS: BC PCs in 35% CPD plasma and 65% platelet-additive solution (PAS III) were exposed to photochemical treatment (PCT) with 150 micro
Minimization of chronic plasma viremia in rhesus macaques immunized with synthetic HIV-1 Tat peptides and infected with a chimeric simian/human immunodeficiency virus (SHIV33).: Vaccine. 2000 Jun 15;18(25):2789-95. Unique Identifier : AIDSLINE MED/20274199; Goldstein G; Manson K; Tribbick G; Smith R; Thymon L.L.C., Short Hills, NJ 07078, USA. gidgold@aol.com; HIV-1 Tat protein activates resting cells, rendering them permissive for viral replication. Replication of HIV-1 in vitro is enhanced by intercellular passage of Tat protein and inhibited by anti-Tat antibodies. Tat dependence of HIV-1 replication in vivo during acute, chronic asymptomatic and AIDS stages of infection
Injection with interleuki