Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment? A ten-year experiment must liberate them [editorial]

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment? A ten-year experiment must liberate them [editorial]

Biomed Pharmacother. 1999 Dec;53(10):484-6. Unique Identifier : AIDSLINE MED/20128727
Mathe G

Abstract: We detected in 1989, with the inhibitor test of proviral insertion into c-erb B erythroblastosis, two retrovirus integrase inhibitors: hydroxy-methyl-ellipticine and acriflavine. They have been used for ten years in AIDS patients with high efficacy and no toxicity. Since vitamin B12 and cobalt, which it contains, have been detected as HIV1-integrase inhibitors by an in-vitro test, we have also used vitamin B12 (combined with folic acid), whose clinical action has been remarkable. Ten or so other compounds have been detected by such in-vitro tests, among which there are many compounds (such as flavones) which are used in many conditions and are not toxic.

Keywords: EDITORIAL REVIEW REVIEW, TUTORIAL JOURNAL ARTICLE Acquired Immunodeficiency Syndrome/*DRUG THERAPY Acriflavine/PHARMACOLOGY/*THERAPEUTIC USE Cobalt/PHARMACOLOGY Ellipticines/PHARMACOLOGY/*THERAPEUTIC USE Human HIV Integrase/METABOLISM HIV Integrase Inhibitors/PHARMACOLOGY/*THERAPEUTIC USE HIV-1/DRUG EFFECTS/ENZYMOLOGY Vitamin B 12/PHARMACOLOGY/THERAPEUTIC USE
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A0052213

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